CN111138699A - Post-treatment process of ethylene propylene diene monomer rubber sealing gasket for aerosol valve - Google Patents
Post-treatment process of ethylene propylene diene monomer rubber sealing gasket for aerosol valve Download PDFInfo
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- CN111138699A CN111138699A CN202010034704.6A CN202010034704A CN111138699A CN 111138699 A CN111138699 A CN 111138699A CN 202010034704 A CN202010034704 A CN 202010034704A CN 111138699 A CN111138699 A CN 111138699A
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- ethylene propylene
- diene monomer
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/02—Chemical treatment or coating of shaped articles made of macromolecular substances with solvents, e.g. swelling agents
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
- C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
- C08J2323/16—Ethene-propene or ethene-propene-diene copolymers
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- Chemical Kinetics & Catalysis (AREA)
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- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
The invention discloses a post-treatment process of an ethylene propylene diene monomer sealing gasket for an aerosol valve, which determines the volume of an extracting solution according to the surface area of an ethylene propylene diene monomer gasket formed by vulcanization; placing the ethylene propylene diene monomer gasket to be treated and the extraction liquid in an extraction container, controlling the extraction temperature of the extraction container, and extracting the ethylene propylene diene monomer gasket at the extraction temperature for a preset time period and then taking out the ethylene propylene diene monomer gasket; and (3) drying the ethylene propylene diene monomer gasket which is taken out, and heating and drying the ethylene propylene diene monomer gasket in an oven at a preset temperature for at least 30 minutes after drying. When the extract adopts pure water, the surface area of the ethylene propylene diene monomer gasket is 1cm2Preparing an extract with a ratio of 1ml of pure water, and when the extract adopts ethanol or isopropanol, preparing the extract according to the surface area of the ethylene propylene diene monomer rubber gasket of 5cm2And ethanol with the proportion of 1 ml. The invention reduces low molecular weight organic matters possibly harmful to human body in the ethylene propylene diene monomer material to the utmost extent, satisfies the requirement of gasThe safety of the aerosol administration system is required.
Description
Technical Field
The invention relates to an after-treatment process of an ethylene propylene diene monomer rubber sealing gasket for an aerosol valve, belonging to the technical field of ethylene propylene diene monomer rubber treatment.
Background
The aerosol is prepared by packaging medicinal solution, emulsion or suspension and proper propellant in a pressure-resistant container with a special valve system, and spraying the content in the form of mist under the pressure of the propellant when in use, and is mainly used for lung inhalation or directly spraying to mucous membrane, skin and space of cavity.
In recent years, pharmaceutical enterprises are greatly increasing in enthusiasm for development of inhalation preparation products, wherein the incidence rate of respiratory diseases such as asthma, Chronic Obstructive Pulmonary Disease (COPD), bronchiectasis and the like is continuously and highly increased, and several key factors are urgently lagged in development of the inhalation preparation products in China and the medicine industry is urgently required to be upgraded and developed. Asthma and chronic obstructive pulmonary disease are important chronic diseases, the inhalation drug ratio in domestic in 2018 is only 13.8%, the industrialization development of inhalation preparations needs the integration of multiple disciplines such as medicine, pharmacy, materials science, powder engineering, precision mold processing and manufacturing, and the quality of final products has close relation with formula process, packaging materials, drug delivery devices, delivery principles and patient use, so that the inhalation drug delivery needs to be promoted and improved urgently.
The container for the inhalation formulation generally comprises a bottle (can) connected to a valve. The valve includes a valve stem through which the formulation is dispensed. Valve systems are important components of aerosols. Because the function of the water-based spraying agent is to make the sprayed contents form water column, or gel, or foam, or mist to achieve the using effect. Valves typically include a rubber stem seal to allow the valve stem to reciprocate while preventing propellant leakage from the container. Metered dose inhalers include a valve designed to deliver a metered amount of aerosol to a recipient per ejection. The metering valve is provided with a gasket (also referred to as a seal) to prevent leakage of propellant from the valve. The gasket may comprise a suitable elastomeric material such as ethylene propylene diene monomer, low density polyethylene, neoprene, nitrile rubber with or without carbon black, butyl rubber, and the like.
Ethylene propylene diene monomer is a third monomer that introduces unsaturation into a copolymer of ethylene and propylene. As the diene as the third monomer, ethylidene norbornene, dicyclopentadiene, 1, 4-hexadiene and the like are mainly mentioned. The ethylene propylene diene monomer rubber has the advantages of aging resistance, impact elasticity, cold resistance, excellent weather resistance, chemical corrosion resistance and good electrical insulation performance. The main production method is solution or suspension polymerization carried out by Ziegler-Natta catalyst, and the product is mainly used for high-grade cable materials and automobile parts, especially for automobile sealing strips, windproof and rainproof rubberized fabrics, waterproof building materials, radiator rubber tubes, shock absorbers, tire side tires and the like. In addition, the ethylene propylene diene monomer rubber is also widely applied to the fields of electronic product sealing, high-grade furniture, construction of building bridges and stadiums, medicine packaging and the like.
The use of conventional neoprene, butyl, or nitrile rubber, etc. as elastomeric seals for aerosol valve systems can result in substantial leakage of 1,1,1, 2-tetrafluoroethane (HFC-134a) or 1,1,1,2,3,3, 3-heptafluoroheptane (HFC-227) as a propellant from some formulations over time. Particularly in low volume formulations, such as pharmaceutical formulations for inhalation therapy, such leakage can result in a substantial increase in the concentration of active ingredient in the formulation, resulting in an inappropriate dosage. In addition, the valve stem of the valve tends to stick, pause, or drag during operation in certain formulations.
CN1330391C and CN1444489A mention that ethylene propylene diene monomer rubber is preferred as a gasket for valve of aerosol container for salmeterol xinafoate formulation, showing good durability of the product and preventing moisture from entering into the aerosol system. Ethylene propylene diene monomer seals for aerosol containers are also described in detail in WO1995002651a 1. In general, in order to improve the service performance of the ethylene propylene diene monomer, a cross-linking agent is required to be added, and a three-dimensional network structure is generated among ethylene propylene diene monomer polymer macromolecules through hot press forming. However, because the double bond content of the ethylene propylene diene monomer is low, the vulcanization speed of a sulfur system is very low, and in order to solve the problem of low vulcanization speed of the ethylene propylene diene monomer, the vulcanization speed is generally improved by using a peroxide cross-linking agent, but the vulcanized ethylene propylene diene monomer material also has the risk of dissolving out low molecular weight organic matters harmful to human bodies, so that the low molecular weight organic matters possibly harmful to human bodies in the ethylene propylene diene monomer material are required to be removed as far as possible by a post-treatment method, and the requirement of the aerosol administration system on the safety of the human bodies is met.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a post-treatment process of an ethylene propylene diene monomer sealing gasket for an aerosol valve, which can remove low-molecular polar organic matters possibly harmful to human bodies in the ethylene propylene diene monomer sealing gasket to the maximum extent.
The technical scheme for solving the technical problems is as follows: an after-treatment process of an ethylene propylene diene monomer rubber sealing gasket for an aerosol valve comprises the following steps: determining the volume of an extraction liquid according to the surface area of the vulcanized ethylene propylene diene monomer gasket, wherein the extraction liquid adopts one of pure water, ethanol or isopropanol; placing an ethylene propylene diene monomer gasket to be treated and an extraction liquid into an extraction container, controlling the extraction temperature of the extraction container, and extracting the ethylene propylene diene monomer gasket at the extraction temperature for a preset time period and then taking out the ethylene propylene diene monomer gasket; and (3) drying the ethylene propylene diene monomer gasket which is taken out, and heating and drying the ethylene propylene diene monomer gasket in an oven at a preset temperature for at least 30 minutes after drying.
As the preferable scheme of the post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve, when the extracting solution adopts pure water, the surface area of the ethylene propylene diene monomer rubber sealing gasket is 1cm2And 1ml of pure water are prepared into an extract:
controlling the pressure of the extraction container to be 0.1-0.15 MPa; putting an ethylene propylene diene monomer gasket to be treated and pure water into an extraction container, controlling the extraction temperature of the extraction container to be 121 ℃, extracting the ethylene propylene diene monomer gasket for 1 hour at the extraction temperature, and taking out the ethylene propylene diene monomer gasket; and (3) drying the ethylene propylene diene monomer gasket which is taken out, and heating and drying the ethylene propylene diene monomer gasket in an oven at 80 ℃ for 30 minutes after the ethylene propylene diene monomer gasket is dried.
As the preferable scheme of the post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve, when the extract adopts ethanol, the surface area of the ethylene propylene diene monomer rubber sealing gasket is 5cm2And 1ml of ethanol are used for preparing an extract:
placing an ethylene propylene diene monomer gasket to be treated and ethanol in an extraction container, controlling the extraction temperature of the extraction container to be room temperature, performing ultrasonic oscillation extraction on the ethylene propylene diene monomer gasket at the extraction temperature for 1 hour, and taking out the ethylene propylene diene monomer gasket; and (3) drying the ethylene propylene diene monomer gasket which is taken out, and heating and drying the ethylene propylene diene monomer gasket in an oven at 80 ℃ for 30 minutes after the ethylene propylene diene monomer gasket is dried.
Excellent post-treatment process of ethylene propylene diene monomer rubber sealing gasket for aerosol valveAccording to the scheme, when the extract adopts isopropanol, the surface area of an ethylene propylene diene monomer rubber gasket is 5cm2And 1ml of pure water are prepared into an extract:
placing an ethylene propylene diene monomer gasket to be treated and isopropanol into an extraction container, controlling the extraction temperature of the extraction container to be room temperature, performing ultrasonic oscillation extraction on the ethylene propylene diene monomer gasket at the extraction temperature for 1 hour, and taking out the ethylene propylene diene monomer gasket; and (3) drying the ethylene propylene diene monomer gasket which is taken out, and heating and drying the ethylene propylene diene monomer gasket in an oven at 80 ℃ for 30 minutes after the ethylene propylene diene monomer gasket is dried.
As the preferable scheme of the post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve, the pure water is prepared by a pure water generator.
As a preferable scheme of the post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve, the ethanol adopts analytically pure 95% ethanol.
As a preferable scheme of the post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve, the isopropanol adopts analytically pure isopropanol.
As a preferred scheme of the post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve, the ethylene propylene diene monomer rubber sealing gasket samples before and after treatment are subjected to weight loss measurement and liquid chromatograph analysis, and the content of the extractable matter in the ethylene propylene diene monomer rubber sealing gasket is determined.
The volume of the extracting solution is determined according to the surface area of the ethylene propylene diene monomer gasket after vulcanization forming, and the ethylene propylene diene monomer gasket is extracted for a preset time at an extraction temperature and then taken out; and drying the ethylene propylene diene monomer gasket in the air, and then heating and drying in an oven at a preset temperature. The technical scheme is simple and easy to implement, the treated sealing gasket has the advantages of few extractables in absolute ethyl alcohol, good air tightness, chemical inertness and good compatibility with medicines, and is suitable for being used in a medicinal aerosol valve system, low molecular weight organic matters possibly harmful to human bodies in ethylene propylene diene monomer materials are reduced to the maximum extent, and the requirement on the human body safety of an aerosol administration system is met.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention more comprehensible, embodiments of the present invention are described in detail below with reference to the accompanying tables. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Example 1
The post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve comprises the following steps: and determining the volume of an extraction liquid according to the surface area of the vulcanized ethylene propylene diene monomer gasket, wherein the extraction liquid adopts pure water, and the pure water adopts pure water prepared by a pure water generator.
According to the surface area of the ethylene propylene diene monomer rubber gasket of 1cm2Preparing an extract solution at a ratio of 1ml of pure water, taking 50 samples, and obtaining a total surface area of about 200cm2Putting the mixture into a pressure container, adding 200ml of pure water: controlling the pressure of the extraction container to be 0.1-0.15 MPa; putting an ethylene propylene diene monomer gasket to be treated and pure water into an extraction container, controlling the extraction temperature of the extraction container to be 121 ℃, extracting the ethylene propylene diene monomer gasket for 1 hour at the extraction temperature, and taking out the ethylene propylene diene monomer gasket; and (3) drying the ethylene propylene diene monomer gasket which is taken out, and heating and drying the ethylene propylene diene monomer gasket in an oven at 80 ℃ for 30 minutes after the ethylene propylene diene monomer gasket is dried.
Example 2
The post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve comprises the following steps: and determining the volume of an extraction liquid according to the surface area of the vulcanized ethylene propylene diene monomer gasket, wherein the extraction liquid adopts ethanol, and the ethanol adopts analytically pure 95% ethanol.
According to the surface area of the ethylene propylene diene monomer rubber gasket of 5cm2The extract was prepared in a proportion of 1ml of ethanol, and 50 samples were taken, the total surface area of which was about 200cm2Putting the mixture into a 200ml clean beaker, adding 40ml of 95% ethanol, controlling the extraction temperature of the extraction container to be room temperature, and taking out the ethylene propylene diene monomer gasket after performing ultrasonic oscillation extraction for 1 hour at the extraction temperature; and (3) drying the ethylene propylene diene monomer gasket at room temperature, and heating and drying the ethylene propylene diene monomer gasket in an oven at 80 ℃ for 30 minutes.
Example 3
The post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve comprises the following steps: and determining the volume of an extraction liquid according to the surface area of the vulcanized ethylene propylene diene monomer gasket, wherein the extraction liquid adopts isopropanol, and the isopropanol adopts analytically pure isopropanol.
According to the surface area of the ethylene propylene diene monomer rubber gasket of 5cm2Preparing an extract solution at a ratio of 1ml of pure water, taking 50 samples, and obtaining a total surface area of about 200cm2Putting the mixture into a 200ml clean beaker, adding 40ml of isopropanol, controlling the extraction temperature of the extraction container to be room temperature, and taking out the ethylene propylene diene monomer gasket after performing ultrasonic oscillation extraction for 1 hour at the extraction temperature; and (3) drying the ethylene propylene diene monomer gasket which is taken out, and heating and drying the ethylene propylene diene monomer gasket in an oven at 80 ℃ for 30 minutes after the ethylene propylene diene monomer gasket is dried.
Comparative example 1
The ethylene propylene diene monomer rubber gasket for the aerosol produced in Europe seals the gasket with the same specification, and a German COG sealing technology AP306 ethylene propylene diene monomer rubber O-shaped ring is taken as a comparative example.
Comparative example 2
And selecting an ethylene propylene diene monomer rubber sealing gasket for the aerosol valve without carrying out post-treatment process. The specific gasket formulation is the same as in examples 1,2 and 3.
When the technical effect of the technical scheme is understood:
it is known that the rubber gasket for aerosol is generally required to control the extractable content in absolute ethanol at present, and the rubber gasket for aerosol is generally accepted at 3% or less in foreign countries. As for what components of the extractables are not specified, the existing liquid chromatography cannot perform qualitative analysis on the extractables, only can be considered as unknown substances, and whether the extractables are harmful to human bodies is not determined, only can be considered as possibly harmful to the human bodies, and after all, the extractables are polar organic substances with low molecular weights.
It is known that, because the analysis of liquid chromatography cannot be qualitative, it cannot use the internal standard or external standard of the known standard sample, the analysis means at the present stage can only compare the total peak area, and the larger the peak area under the same experimental condition is, the more extractables extracted from the absolute ethyl alcohol is.
TABLE 1 ethylene propylene diene monomer rubber gasket sample Absolute ethanol extractable content before and after treatment
TABLE 2 post-treatment chemical properties of ethylene propylene diene monomer rubber gaskets
| Test items | Standard value | Example 1 | Example 2 | Example 3 |
| Clarity and color | Clear and colorless | Clear and colorless | Clear and colorless | Clear and colorless |
| Change in pH value | ≤1.0 | 0.32 | 0.44 | 0.28 |
| Absorbance of ultraviolet | ≤0.2 | 0.038 | 0.025 | 0.017 |
| Nonvolatile (mg) | ≤4.0mg | 0.4 | 0.2 | 0.2 |
| Oxidizable compound (mL) | ≤3.0 | 0.15 | 0.12 | 0.10 |
| Heavy metals | ≤1ppm | Compliance with regulations | Compliance with regulations | Compliance with regulations |
| Ammonium ion | Should comply with the regulations | Compliance with regulations | Compliance with regulations | Compliance with regulations |
| Zinc ion | Should comply with the regulations | Compliance with regulations | Compliance with regulations | Compliance with regulations |
| Conductivity (us/cm) | ≤40.0 | 8.73 | 8.77 | 8.46 |
| Heat source test | Should comply with the regulations | Compliance with regulations | Compliance with regulations | Compliance with regulations |
| Hemolysis test | Should comply with the regulations | Compliance with regulations | Compliance with regulations | Compliance with regulations |
| Acute systemic toxicity test | Should comply with the regulations | Compliance with regulations | Compliance with regulations | Compliance with regulations |
See table 1 for absolute ethanol extractable content of ethylene propylene diene monomer rubber gasket samples before and after treatment. See table 2 for the post-treatment chemical properties of the epdm rubber gasket.
Specifically, weightlessness measurement and liquid chromatograph analysis are carried out on the ethylene propylene diene monomer rubber sealing gasket samples before and after treatment, and the content of the extractable matter in the ethylene propylene diene monomer rubber sealing gasket is determined. And (3) performing Soxhlet extraction on the treated sample for 48 hours by using absolute ethyl alcohol, and performing weight loss measurement and liquid chromatograph analysis to determine the content of the absolute ethyl alcohol extractable matter in the sealing gasket. The weight of the sample before and after the treatment was measured by using a precision balance and a high performance liquid chromatograph.
Specifically, the calculation method of Soxhlet extraction weight loss comprises the following steps:
the absolute ethanol extractable content (weight loss) is (weight of sample before extraction-weight of sample after extraction)/weight of sample before extraction x 100%.
Sample weighing A QUINTIX1250-ICN ten thousandth electronic balance manufactured by Saedodes scientific instruments (Beijing) Co., Ltd was used. High performance liquid chromatography: the ratio of the total peak area of the samples of example and comparative example 2 to the total peak area of the foreign sample was set to 1. The high performance liquid chromatograph used was UltiMate3000 manufactured by U.S. thermoelectric corporation.
The content of the extractables in the treated sample in the absolute ethyl alcohol is obviously lower than that of the untreated sample, and compared with the similar products in foreign countries, the content of the extractables in the absolute ethyl alcohol is equal to or better than that of the similar products in foreign countries.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (8)
1. An after-treatment process of an ethylene propylene diene monomer rubber sealing gasket for an aerosol valve is characterized by comprising the following steps: determining the volume of an extraction liquid according to the surface area of the vulcanized ethylene propylene diene monomer gasket, wherein the extraction liquid adopts one of pure water, ethanol or isopropanol; placing an ethylene propylene diene monomer gasket to be treated and an extraction liquid into an extraction container, controlling the extraction temperature of the extraction container, and extracting the ethylene propylene diene monomer gasket at the extraction temperature for a preset time period and then taking out the ethylene propylene diene monomer gasket; and (3) drying the ethylene propylene diene monomer gasket which is taken out, and heating and drying the ethylene propylene diene monomer gasket in an oven at a preset temperature for at least 30 minutes after drying.
2. The post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve as claimed in claim 1, wherein when the extracting solution adopts pure water, the surface area of the ethylene propylene diene monomer rubber sealing gasket is 1cm2And 1ml of pure water are prepared into an extract:
controlling the pressure of the extraction container to be 0.1-0.15 MPa; putting an ethylene propylene diene monomer gasket to be treated and pure water into an extraction container, controlling the extraction temperature of the extraction container to be 121 ℃, extracting the ethylene propylene diene monomer gasket for 1 hour at the extraction temperature, and taking out the ethylene propylene diene monomer gasket; and (3) drying the ethylene propylene diene monomer gasket which is taken out, and heating and drying the ethylene propylene diene monomer gasket in an oven at 80 ℃ for 30 minutes after the ethylene propylene diene monomer gasket is dried.
3. The post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve as claimed in claim 1, wherein when the extract adopts ethanol, the surface area of the ethylene propylene diene monomer rubber sealing gasket is 5cm2And 1ml of ethanol are used for preparing an extract:
placing an ethylene propylene diene monomer gasket to be treated and ethanol in an extraction container, controlling the extraction temperature of the extraction container to be room temperature, performing ultrasonic oscillation extraction on the ethylene propylene diene monomer gasket at the extraction temperature for 1 hour, and taking out the ethylene propylene diene monomer gasket; and (3) drying the ethylene propylene diene monomer gasket which is taken out, and heating and drying the ethylene propylene diene monomer gasket in an oven at 80 ℃ for 30 minutes after the ethylene propylene diene monomer gasket is dried.
4. The post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve as claimed in claim 1, wherein when the extract adopts isopropanol, the surface area of the ethylene propylene diene monomer rubber sealing gasket is 5cm2And 1ml of pure water are prepared into an extract:
placing an ethylene propylene diene monomer gasket to be treated and isopropanol into an extraction container, controlling the extraction temperature of the extraction container to be room temperature, performing ultrasonic oscillation extraction on the ethylene propylene diene monomer gasket at the extraction temperature for 1 hour, and taking out the ethylene propylene diene monomer gasket; and (3) drying the ethylene propylene diene monomer gasket which is taken out, and heating and drying the ethylene propylene diene monomer gasket in an oven at 80 ℃ for 30 minutes after the ethylene propylene diene monomer gasket is dried.
5. The post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve as claimed in claim 1, wherein the pure water is prepared by a pure water generator.
6. The post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve as claimed in claim 1, wherein the ethanol is analytically pure 95% ethanol.
7. The post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve as claimed in claim 1, wherein the isopropanol adopts analytically pure isopropanol.
8. The post-treatment process of the ethylene propylene diene monomer rubber sealing gasket for the aerosol valve according to claim 1, wherein the weight loss measurement and the analysis of a liquid chromatograph are carried out on samples of the ethylene propylene diene monomer rubber sealing gasket before and after treatment, so as to determine the content of the extractable matter in the ethylene propylene diene monomer rubber sealing gasket.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112111081A (en) * | 2020-09-21 | 2020-12-22 | 郑州大学 | Production method of rubber sealing ring for medicinal aerosol valve |
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| CN112111081B (en) * | 2020-09-21 | 2023-01-31 | 郑州大学 | Production method of rubber sealing ring for medicinal aerosol valve |
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