CN111128432A - Electron accelerator-based90Y production system and method - Google Patents

Electron accelerator-based90Y production system and method Download PDF

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Publication number
CN111128432A
CN111128432A CN201911336817.5A CN201911336817A CN111128432A CN 111128432 A CN111128432 A CN 111128432A CN 201911336817 A CN201911336817 A CN 201911336817A CN 111128432 A CN111128432 A CN 111128432A
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China
Prior art keywords
electron
target
neutrons
production system
neutron
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冷志涛
陈浩
周霖
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Chengdu Minak Enterprise Management Consulting Partnership LP
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Chengdu Minak Enterprise Management Consulting Partnership LP
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    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
    • G21G1/06—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by neutron irradiation
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H13/00—Magnetic resonance accelerators; Cyclotrons
    • H05H13/005—Cyclotrons

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  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Plasma & Fusion (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Particle Accelerators (AREA)

Abstract

The invention discloses a method based on an electron accelerator90The Y production system and the method comprise an electron generation section, an electron acceleration section, an electron-neutron conversion part, a neutron moderation shaping part, a target irradiation part, a first cooling part, a second cooling part and a collection part. The invention provides a novel electronic accelerator-based90The production mode of Y avoids the defects of the existing production mode, and improves90Portability and safety of Y production.

Description

Electron accelerator-based90Y production system and method
Technical Field
The invention belongs to the field of nuclear technology application, and particularly relates to an electron accelerator-based method90Y production system and method.
Background
90Y is an important medical radionuclide, has wide application prospect in Radioimmunotherapy (RIT) of tumors, has proper physical half-life (T is 64.0h), and emits pure β﹣Particles with high β energy (maximum energy of 2.3MeV, average energy of 0.93MeV), average tissue range of 2.5mm and maximum 11.9mm, calculated by cell diameter of 20um, can kill cells within the range of 150-200 cell diameters, has killing effect within the range of 500-600 cell diameters, and decays word daughter90Zr is stable and nontoxic.
90There are two production methods for Y: one is high purity by neutron irradiation in reactor89Y2O3Target production90And Y. Reactor irradiation production90Y is utilization89Y(n,γ)90Y is reacted with89Y2O3Irradiation generation of fabricated targets in a reactor90And Y. The disadvantage of this method is that it is not satisfactory for the remote location of the reactor90Requirement of Y, obtained90The specific activity of Y is low and cannot be directly used for radioimmunotherapy. The other is from90Separation in decay equilibrium system of Sr90Y。90Sr is235Fission product of U, fission yield of about 5.772%. From90Separation in Sr decay equilibrium system90Y operation is simple, no neutron source is needed, production can be carried out at a place far away from the reactor, and the obtained product90The specific activity of Y is high, but this method inevitably brings a small amount of high toxicity in the separation process90Sr causes pollution and harm to human body.
Patent CN108028086A proposes an electron accelerator based90The Y production mode is that the electron beam bombards the high atomic number matter to produce photoneutron, which is further interacted with natural zirconium or concentrated zirconium material to produce90Y, by90Zr(n，p)90Y reaction generation90Y, but in natural zirconium90The Zr content is only 51.45%, and the direct bombardment of natural zirconium or concentrated zirconium material by neutrons can cause90The yield of Y is not high if91Extraction of Zr increases the production cost and equipment complexity.
Therefore, it is necessary to provide a method for producing the same90Y mode of production capable of producing high activity at a place far from the reactor90Y, and produced90And Y does not contain toxic substances.
Disclosure of Invention
In order to overcome the defects, the inventor of the invention provides an electron accelerator-based electron accelerator through long-term exploration and trial and many experiments and efforts90Y production system capable of overcoming the existing90The deficiency of the Y production mode, high production activity and high safety at the place far away from the reactor90Y for use in radioimmunotherapy.
The technical scheme adopted by the invention for achieving the aim is that the invention is based on an electron accelerator90A Y production system comprising the following structure:
an electron generation section for generating electrons;
the electron acceleration section is used for accelerating and transporting the electron beam;
the electron-neutron conversion part is used for receiving the electron beam current transmitted by the electron acceleration section and converting the electron beam current into bremsstrahlung photons, and the bremsstrahlung photons further interact with the electron-neutron conversion part to generate photoneutrons;
a neutron shaping and slowing part for receiving neutrons of the electron-neutron conversion part and shaping and slowing the neutrons to be below 1 MeV;
a target irradiation part for receiving neutrons below 1MeV of the electron-neutron conversion part, wherein 1 or more target holders are accommodated in the target holder89Y2O3The target disk is provided with a target disk,89Y2O3produced by interaction with neutrons90Y；
The first cooling part is hermetically connected with the electron-photon conversion part and used for cooling the electron-neutron conversion part by using cooling liquid circulation;
the second cooling part is hermetically connected with the target irradiation part and used for cooling the target irradiation part by using cooling liquid circulation;
a collecting part connected with the target irradiating part for collecting the light generated by the target irradiating part90Y。
According to the invention, an electron accelerator is used90The Y production system further adopts the following preferable technical scheme:the electron energy generated by the electron generation section is between 10MeV and 50 MeV.
According to the invention, an electron accelerator is used90The Y production system further adopts the following preferable technical scheme: the electron acceleration section comprises an acceleration channel, a microwave power source, a vacuum device and a beam guiding and focusing system, the acceleration channel is connected with the electron generation section, and the vacuum device, the microwave power source and the beam guiding and focusing system are respectively connected with the acceleration channel.
According to the invention, an electron accelerator is used90The Y production system further adopts the following preferable technical scheme: the accelerating channel is a metal pipeline and is used for transporting electron beam flow.
According to the invention, an electron accelerator is used90The Y production system further adopts the following preferable technical scheme: the vacuum equipment is used for vacuumizing the acceleration channel and monitoring the vacuum state of the acceleration channel.
According to the invention, an electron accelerator is used90The Y production system further adopts the following preferable technical scheme: the guiding focusing system guides and restrains electrons in the accelerating channel by using a certain form of electromagnetic field, so that the electrons are accelerated by the accelerating electric field along a preset track.
According to the invention, an electron accelerator is used90The Y production system further adopts the following preferable technical scheme: the guiding focusing system is a dominant magnetic field or a quadrupole lens field of the circular accelerator.
According to the invention, an electron accelerator is used90The Y production system further adopts the following preferable technical scheme: the microwave power source is a magnetron or a klystron, and is used for providing microwaves with specific frequency in the acceleration channel so as to realize the acceleration of electrons.
According to the invention, an electron accelerator is used90The Y production system further adopts the following preferable technical scheme: the electron-neutron conversion part is at least one of a tungsten target, a gold target or a tantalum target.
Based on the production system, the invention also provides a production method based on the electron accelerator90A Y production process comprising:
generating electrons; receiving the electron beam current and converting the electron beam current into bremsstrahlung photons, and further enabling the bremsstrahlung photons to interact with the electron-neutron conversion part to generate photoneutrons; receiving photoneutrons and shaping the photoneutrons to be slowed down into neutrons below 1 MeV; receiving neutrons below 1MeV, and accommodating 1 or more neutrons in the target holder89Y2O3The target disk is provided with a target disk,89Y2O3produced by interaction with neutrons90Y。
The beneficial effect of prior art is compared in this application:
90y can be produced by reaction89Y(n，γ)90Y, and the composition of the Y element in the nature is one hundred percent89Y, if adopted89Y material as target material, neutrons can react with89Y is fully reacted and improved90Production efficiency of Y by electron accelerator and89y material combination product90Y, not only can overcome the production of reactor90Y can overcome the defects of impure target material and difficult extraction in CN 108028086A.
Based on the above, the invention provides an electron accelerator-based90Y production mode, can overcome the existing90The deficiency of the Y production mode, high production activity and high safety at the place far away from the reactor90Y for use in radioimmunotherapy.
The invention provides a method based on an electron accelerator90Y production system capable of overcoming the existing90The deficiency of the Y production mode, high production activity and high safety at the place far away from the reactor90Y for use in radioimmunotherapy.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is a schematic block diagram of the system of the present invention.
Fig. 2 is a basic structure of the electron acceleration section.
FIG. 3 is a schematic diagram of a neutron moderating and shaping apparatus.
FIG. 4 is89Y(n，γ)90Y reaction scheme.
FIG. 5 shows neutrons and89reaction cross-section of Y.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, not all of the embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. Thus, the detailed description of the embodiments of the present invention provided below is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention.
Example 1
FIG. 1 is a schematic block diagram of the system of the present invention, an electron accelerator based90A Y production system, comprising: an electron generation section for generating electrons;
the electron acceleration section is used for accelerating and transporting the electron beam;
the electron-neutron conversion part is used for receiving the electron beam current transmitted by the electron acceleration section and converting the electron beam current into bremsstrahlung photons, and the bremsstrahlung photons further interact with the electron-neutron conversion part to generate photoneutrons;
a neutron shaping and slowing part for receiving neutrons of the electron-neutron conversion part and shaping and slowing the neutrons to be below 1 MeV;
target irradiation part, 1MeV receiving electron-neutron conversion partWherein 1 or more target holders are accommodated89Y2O3The target disk is provided with a target disk,89Y2O3produced by interaction with neutrons90Y；
The first cooling part is hermetically connected with the electron-photon conversion part and used for cooling the electron-neutron conversion part by using cooling liquid circulation;
the second cooling part is hermetically connected with the target irradiation part and used for cooling the target irradiation part by using cooling liquid circulation;
a collecting part connected with the target irradiating part for collecting the light generated by the target irradiating part90Y。
The electron generation section generates an electron beam current with energy between 10MeV and 50MeV, and the electron acceleration section is used for accelerating and transporting electrons generated by the electron generation section. As shown in fig. 2, the electron acceleration section includes an acceleration channel, a microwave power source, a vacuum device, and a beam steering focusing system, the acceleration channel is connected to the electron generation section, and the vacuum device, the microwave power source, and the beam steering focusing system are respectively connected to the acceleration channel.
Wherein the accelerating channel is a metal pipeline used for transporting electron beam flow.
The vacuum equipment is used for vacuumizing the acceleration channel and monitoring the vacuum state of the acceleration channel.
The guiding focusing system guides and restrains electrons in the accelerating channel by using a certain form of electromagnetic field, so that the electrons are accelerated by the accelerating electric field along a preset track. Such as the dominant magnetic field of a circular accelerator or a quadrupole lens field.
The microwave power source is a magnetron or a klystron, and is used for providing microwaves with specific frequency in the accelerating channel so as to realize the acceleration of electrons.
The electron-neutron conversion part receives electron beam current between 10MeV and 50MeV transmitted from the electron acceleration section and converts the received electrons into neutrons, wherein the electron-neutron conversion part is at least one of a tungsten target, a gold target or a tantalum target, and the first cooling part cools the electron-neutron conversion part in a cooling liquid circulation mode.
FIG. 3 is a schematic diagram of a neutron moderating and shaping apparatusThe moderating and shaping end comprises a photoneutron channel 001 for transporting photoneutrons; a neutron slowing layer for slowing down the high-energy neutrons (more than 1MeV) to neutrons (less than 1MeV) ((<0.5 eV). FIG. 5 shows neutrons and89reaction section of Y, it can be seen that neutrons and89the resonance peak of Y appears below 1MeV, and the lower the energy, the larger the reaction section, the neutrons below 1MeV and89the reaction section of Y is larger, and when the neutron energy is more than 1MeV, the neutron is connected with89Reaction cross section of Y is small, produced90Y is very small. The neutron reflecting layer 003 is used for reflecting neutrons and preventing the neutrons from diffusing to the periphery; a neutron collimation layer 004 for collimating the neutron beam to enable the neutron beam to be emitted along the center; and the photon filtering layer 005 is used for filtering photons in the neutron beam. Neutron moderation layer 002 sets up around photoneutron passageway 001, neutron reflection stratum 003 sets up around neutron moderation layer 002, photon filter layer 005 sets up between photoneutron passageway 001 and neutron collimation layer 004, and neutron collimation layer 004 sets up in photoneutron passageway 001 export.
The target irradiation part is integrally 1 target holder for receiving neutrons below 1MeV generated by the neutron moderation shaping device, wherein the target holder can accommodate 1 or more89Y2O3A target disc; neutrons below 1MeV and89y is reacted to produce90Y, reaction process shown in FIG. 4, neutron and89y interaction generates 190Y and photons generated by the collecting section on the target irradiating section90And Y is collected, and the second cooling part cools the target irradiation part in a cooling liquid circulation mode.
In this embodiment, the first cooling portion and the second cooling portion are cooling tanks having a circulation loop, the cooling tanks are filled with cooling liquid, the cooling tanks are connected with the equipment, and the cooling liquid circulates in the cooling tanks to cool the equipment.
In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
The above is only a preferred embodiment of the present invention, and it should be noted that the above preferred embodiment should not be considered as limiting the present invention, and the protection scope of the present invention should be subject to the scope defined by the claims. It will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the spirit and scope of the invention, and these modifications and adaptations should be considered within the scope of the invention.

Claims (10)

1. Electron accelerator-based90Y production system, its characterized in that includes:
an electron generation section for generating electrons;
the electron acceleration section is used for accelerating and transporting the electron beam;
the electron-neutron conversion part is used for receiving the electron beam current transmitted by the electron acceleration section and converting the electron beam current into bremsstrahlung photons, and the bremsstrahlung photons further interact with the electron-neutron conversion part to generate photoneutrons;
a neutron shaping and slowing part for receiving neutrons of the electron-neutron conversion part and shaping and slowing the neutrons to be below 1 MeV;
a target irradiation part for receiving neutrons below 1MeV of the electron-neutron conversion part, wherein 1 or more target holders are accommodated in the target holder89Y2O3The target disk is provided with a target disk,89Y2O3produced by interaction with neutrons90Y；
The first cooling part is hermetically connected with the electron-photon conversion part and used for cooling the electron-neutron conversion part by using cooling liquid circulation;
the second cooling part is hermetically connected with the target irradiation part and used for cooling the target irradiation part by using cooling liquid circulation;
a collecting part connected with the target irradiation part and used for collecting the generated target irradiation partIs/are as follows90Y。
2. An electron accelerator based on claim 190Y production system, its characterized in that: the electron energy generated by the electron generation section is between 10MeV and 50 MeV.
3. An electron accelerator based on claim 190Y production system, its characterized in that: the electron acceleration section comprises an acceleration channel, a microwave power source, a vacuum device and a beam guiding and focusing system, the acceleration channel is connected with the electron generation section, and the vacuum device, the microwave power source and the beam guiding and focusing system are respectively connected with the acceleration channel.
4. An electron accelerator based on claim 390Y production system, its characterized in that: the accelerating channel is a metal pipeline and is used for transporting electron beam current.
5. An electron accelerator based on claim 390Y production system, its characterized in that: the vacuum equipment is used for vacuumizing the acceleration channel and monitoring the vacuum state of the acceleration channel.
6. An electron accelerator based on claim 390Y production system, its characterized in that: the guiding focusing system guides and restrains electrons in the accelerating channel by using a certain form of electromagnetic field, so that the electrons are accelerated by the accelerating electric field along a preset track.
7. An electron accelerator based on claim 690Y production system, its characterized in that: the guiding focusing system is a dominant magnetic field or a quadrupole lens field of the circular accelerator.
8. An electron accelerator based on claim 390Y production system, its special featureCharacterized in that: the microwave power source is a magnetron or a klystron, and is used for providing microwaves with specific frequency in the acceleration channel so as to realize the acceleration of electrons.
9. An electron accelerator based on claim 190Y production system, its characterized in that: the electron-neutron conversion part is at least one of a tungsten target, a gold target or a tantalum target.
10. Electron accelerator-based90The Y production method is characterized by comprising the following steps: the electron generation section generates electrons; the electron-neutron conversion part receives the electron beam current and converts the electron beam current into bremsstrahlung photons, and the bremsstrahlung photons further interact with the electron-neutron conversion part to generate photoneutrons; receiving photoneutrons and shaping the photoneutrons to be slowed down into neutrons below 1 MeV; receiving neutrons below 1MeV, and accommodating 1 or more neutrons in the target holder89Y2O3The target disk is provided with a target disk,89Y2O3produced by interaction with neutrons90Y。
CN201911336817.5A 2019-12-23 2019-12-23 Electron accelerator-based90Y production system and method Withdrawn CN111128432A (en)

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CN201911336817.5A CN111128432A (en) 2019-12-23 2019-12-23 Electron accelerator-based90Y production system and method

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Application Number Priority Date Filing Date Title
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CN111128432A true CN111128432A (en) 2020-05-08

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Application publication date: 20200508