CN111128375B - Tibetan medicine diagnosis auxiliary device based on multi-label learning - Google Patents
Tibetan medicine diagnosis auxiliary device based on multi-label learning Download PDFInfo
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Abstract
The invention belongs to the field of national medicine aided decision making, and particularly provides a Tibetan medicine diagnosis assisting device based on multi-label learning, which is used for solving some problems in the traditional Tibetan medicine legislation process: namely inaccuracy, difference and lack of objective explanation of diagnosis results, the invention can provide auxiliary decision support for the diagnosis and treatment process of Tibetan doctors, and has the following advantages: 1) constructing a characteristic view: dynamically updating the feature view through continuous iteration of the training process; 2) and (3) label transmission: the most reliable samples are transmitted between the 3 classifiers in pairs, the classifiers are optimized, and the classification accuracy is improved; 3) selecting an optimal classification result: and selecting the optimal prediction result by using a method combining vector splicing and weight distribution.
Description
Technical Field
The invention belongs to the field of national medicine auxiliary decision making, and particularly relates to a Tibetan medicine diagnosis auxiliary device based on multi-label learning.
Background
Tibetan medicine is an important component of the medical treasury of China, has a long history of more than three thousand years and makes a great contribution to the prosperity of the Tibetan nationality and the whole Chinese nation; the scientific research and the inheritance of the Tibetan medicine are paid attention. In the clinical trial of Tibetan medicine, the physician mainly carries out the diagnosis and treatment of the patient according to the following 3 steps: 1) syndrome differentiation: doctors determine the syndrome type of patients according to the etiology and pathogenesis, 2) legislation: determining a treatment method according to the syndrome of the patient, and 3) composing a formula: making a prescription according to syndrome type and treatment; the treatment method is the basis of the clinical prescription sending, the method is established according to the syndrome, the method is established according to the method, and the result of the establishment directly influences the clinical curative effect. In recent years, many researchers use association rules, cluster analysis, topic models and other methods to mine effective Tibetan medical treatment rules from a large number of clinical cases, but all the methods mainly focus on syndrome differentiation and formula rule analysis. The research on the Tibetan medicine legislative rule is still in the traditional manual method stage, namely, doctors predict the therapeutic method according to long-term accumulated self experience.
When the traditional manual method is used for predicting the Tibetan medicine method, the accuracy of diagnosis results is reduced mainly by depending on personal experiences of doctors, different doctors may obtain different methods, and the diagnosis results obtained according to the personal experiences of the doctors are lack of objective explanation.
Disclosure of Invention
The invention aims to provide a Tibetan medicine diagnosis auxiliary device based on multi-label learning aiming at some problems in the traditional Tibetan medicine legislation process, namely inaccuracy, difference and lack of objectivity explanation of diagnosis results, and provides auxiliary decision support for the diagnosis and treatment process of Tibetan doctors.
In order to achieve the purpose, the invention adopts the technical scheme that:
a Tibetan medicine diagnosis assisting device based on multi-label learning, which comprises an input device for inputting symptoms, syndrome outlines and syndromes, and a classifier for receiving the input symptoms, syndrome outlines and syndromes, wherein the classifier is obtained by training the following processes:
step 1: constructing a data set comprising: m chronic kidney disease cases with treatment labels are called as a marked case set for short, and N chronic kidney disease cases without treatment labels are called as a unmarked case set for short;
step 2: training initial classifier based on feature view
Step 2.1: initializing a characteristic view: randomly extracting 1 case from the marked case set, and taking corresponding symptoms, syndrome and machine summaries and syndromes as 3 initialized feature views respectively;
step 2.2: training an initial classifier: training a classifier based on symptom features, a classifier based on syndrome machine summary features and a classifier based on syndrome features on 3 feature views by using an ML-KNN method based on a labeled case set, and sequentially labeling the classifiers as classifiers 1,2 and 3; and updating the corresponding 3 feature views after the training process is completed each time; repeating the training until all the marked cases are trained;
and step 3: optimizing classifier
Step 3.1: and (4) predicting a classification result: using 3 classifiers obtained by training to carry out classification prediction on the unmarked case set to obtain a prediction result
Wherein v represents a classifier number,a probability vector representing the classifier v predicting case j,represents the probability that the label of case j is t, where t is 1,2,.., K is the total number of therapeutic (labels) given a classifier v;
step 3.2: updating the prediction result:
wherein,mark representing case j under the condition that classifier is v after updatingThe probability of the signature being t,a probability vector representing the updated classifier v prediction case j;
C(ta,tb) Indicates the label taAnd a label tbThe correlation of (a):
C(ta,tb)≠C(tb,ta)
wherein,representing simultaneous inclusion of labels t in a marked case setaAnd tbThe number of cases (a) of (b),representing only labels t in a marked case setbThe number of cases of (c);
step 3.3: calculating the global reliability of the prediction case j:
wherein Hv(j, t) represents the reliability of case j on label t:
step 3.4: performing descending order according to the global reliability, and selecting the first n cases as a reliable case set BvTransferring reliable case sets among the 3 classifiers, removing the reliable case sets corresponding to the unmarked case sets, adding the reliable case sets into the marked case sets to form new marked case sets, and training each classifier again on the new marked case sets by using an ML-KNN method;
step 3.5: repeating the steps 3.1-3.4 until the unmarked case set is empty; obtaining 3 final trained classifiers;
and 4, step 4: outputting an optimal classification result:
where α, β, γ are preset weights for classifiers 1,2, 3, respectively, and α + β + γ is 1.
The invention has the beneficial effects that:
the invention provides a Tibetan medicine diagnosis auxiliary device based on multi-label learning, which provides auxiliary decision support for the diagnosis and treatment process of Tibetan doctors; has the following advantages:
1) constructing a characteristic view: dynamically updating the feature view through continuous iteration of the training process;
2) and (3) label transmission: the most reliable samples are transmitted between the 3 classifiers in pairs, the classifiers are optimized, and the classification accuracy is improved;
3) selecting an optimal classification result: and selecting the optimal prediction result by using a method combining vector splicing and weight distribution.
Drawings
Fig. 1 is a schematic diagram of a training process of a classifier according to an embodiment of the present invention.
FIG. 2 is a diagram of a model structure of a classifier according to an embodiment of the present invention.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and examples.
For the purpose of facilitating an understanding of the present invention, reference will first be made to the basic definitions to which the invention relates:
symptoms are: the disease symptoms and clinical manifestations of the disease, such as sweating, dizziness, tinnitus, fever and the like, are the original basis for judging the disease;
the syndrome: the disease diagnosis and treatment method comprehensively analyzes various symptoms and summarizes the pathological aspects of the etiology, the disease location, the disease nature and the like at a certain stage in the process of the occurrence and the development of the diseases;
the summary of the certificate machine: the method refers to the summary of etiology and pathogenesis, wherein the etiology refers to the cause of a disease, and the pathogenesis refers to the mechanism of occurrence, development, change and fate of the disease;
therapeutic method: it refers to the basic method of treating diseases, such as warming the stomach to dispel cold.
In the embodiment, the medical record of chronic kidney disease is taken as data to carry out the recommendation and research of Tibetan medicine and treatment method, and the medical record data mainly comprises four parts of symptoms, syndrome and machine summary, syndrome and treatment method; in the chronic kidney disease medical record data set, most medical records contain at least 2 treatments. Therefore, the Tibetan medicine therapeutic method prediction is treated as a multi-label classification problem, namely, the Tibetan medicine therapeutic method prediction is classified and predicted by taking a therapeutic method as a label and taking symptoms, syndrome outlines and syndromes as 3 different attribute characteristics.
The embodiment provides a Tibetan medicine diagnosis auxiliary device based on multi-label learning, which comprises an input device for inputting symptoms, a syndrome summary and syndromes, and a classifier for receiving the input symptoms, the syndrome summary and the syndromes, wherein the training process of the classifier is as shown in fig. 1, and specifically comprises the following steps:
step 1: constructing a data set comprising: m chronic kidney disease cases with treatment labels are called as a marked case set for short, and N chronic kidney disease cases without treatment labels are called as a unmarked case set for short;
step 2: training initial classifier based on feature view
Step 2.1: initializing a characteristic view: randomly extracting 1 case from the marked case set, and taking corresponding symptoms, syndrome and machine summaries and syndromes as 3 initialized feature views respectively; each characteristic view is a matrix representation formed by a plurality of characteristic vectors;
step 2.2: training an initial classifier: based on the labeled case set, training 3 different classifiers, namely a classifier based on symptom features, a classifier based on syndrome machine summary features and a classifier based on syndrome features, on 3 feature views by using an ML-KNN method, and sequentially labeling the classifiers as classifiers 1,2 and 3; after each training process is finished, updating 3 corresponding feature views, namely sequentially adding three features of symptoms, syndrome and machine summary and syndrome of the current case into the corresponding feature views until all the marked cases are trained; in the embodiment, in order to ensure that the features do not repeatedly appear, a complete word matching method is used for judging whether the same features appear in the current feature view or not in the process of adding the features;
and step 3: optimizing classifier
Step 3.1: and (4) predicting a classification result: the trained 3 classifiers are used to perform classification prediction on the unlabeled case set, as follows:
wherein v represents a classifier number,a label representing case j predicted using classifier v,represents the probability that the label of case j is t, where t is 1,2,.., K is the total number of therapeutic (labels) given a classifier v;
step 3.2: updating the prediction result: the phenomenon of class imbalance may exist in the labeled case set, that is, the number of related cases of a certain label is far less than that of related cases of another label, so that the classification accuracy is reduced; to address this issue, we use tag correlation to update their prediction results;
defining the label correlation as the correlation between every two of K kinds of labels, and calculating the following steps:
C(ta,tb)≠C(tb,ta)
wherein,indicating simultaneous inclusion of a tag taAnd tbThe number of cases (a) of (b),representing the inclusion of only the tag tbThe number of cases of (c);
the result of the prediction is updated and,representing the probability of the label of case j being t after updating the classifier,a vector representation representing the prediction probability over K labels;
step 3.3: calculating the global reliability of the prediction case j:
wherein Hv(j, t) represents the reliability of case j on label t as follows:
step 3.4: and (3) label transmission: performing descending order according to the global reliability, and selecting the first n cases as a reliable case set BvTransferring reliable case sets among the 3 classifiers, removing the reliable case sets corresponding to the unmarked case sets, adding the reliable case sets into the marked case sets to form new marked case sets, and training each classifier again on the new marked case sets by using an ML-KNN method so as to optimize the classifiers; as shown in fig. 2, the classifier 1 corresponds to a reliable case set B1The information is transmitted to classifiers 2 and 3, and so on, so that the classifier 1 is based on the reliable case set B2Reliable case set B3Training again;
step 3.5: repeating the steps 3.1-3.4 until the unmarked case set is empty; obtaining 3 final trained classifiers;
and 4, step 4: outputting the optimal classification result
Selecting an optimal prediction result by using a method combining vector splicing and weight distribution;
α+β+γ=1
wherein, the parameters alpha, beta and gamma are respectively the weight distribution of 3 classifiers, and the parameters are optimized and adjusted according to the experimental result; p is a radical ofjIs a K-dimensional probability vector, and each element corresponds to the probability of a label (law).
By adopting the technical scheme of the invention, the test results are shown in the following table 1.
The treatment results in table 1 are analyzed by Tibetan physicians in the Tibetan hospital of Qinghai province, and the results show that the accuracy of the label of the treatment predicted by using the method provided by the invention reaches 83.4%, which is superior to the accuracy of the treatment prediction performed by the existing method. Compared with traditional manual methods for Tibetan diagnosis prediction, the method can provide objective treatment recommendation for doctors, provides auxiliary decision for the diagnosis process of the doctors, can effectively improve the treatment accuracy rate particularly for young doctors with insufficient experience, and provides better diagnosis and treatment schemes for patients.
TABLE 1
While the invention has been described with reference to specific embodiments, any feature disclosed in this specification may be replaced by alternative features serving the same, equivalent or similar purpose, unless expressly stated otherwise; all of the disclosed features, or all of the method or process steps, may be combined in any combination, except mutually exclusive features and/or steps.
Claims (1)
1. A Tibetan medicine diagnosis assisting device based on multi-label learning, which comprises an input device for inputting symptoms, syndrome outlines and syndromes, and a classifier for receiving the input symptoms, syndrome outlines and syndromes, wherein the classifier is obtained by training the following processes:
step 1: constructing a data set comprising: m chronic kidney disease cases with treatment labels are called as a marked case set for short, and N chronic kidney disease cases without treatment labels are called as a unmarked case set for short;
step 2: training initial classifier based on feature view
Step 2.1: initializing a characteristic view: randomly extracting 1 case from the marked case set, and taking corresponding symptoms, syndrome and machine summaries and syndromes as 3 initialized feature views respectively;
step 2.2: training an initial classifier: training a classifier based on symptom features, a classifier based on syndrome machine summary features and a classifier based on syndrome features on 3 feature views by using an ML-KNN method based on a labeled case set, and sequentially labeling the classifiers as classifiers 1,2 and 3; and updating the corresponding 3 feature views after the training process is completed each time; repeating the training until all the marked cases are trained;
and step 3: optimizing classifier
Step 3.1: and (4) predicting a classification result: using 3 classifiers obtained by training to carry out classification prediction on the unmarked case set to obtain a prediction result
Wherein v represents a classifier number,a probability vector representing the classifier v predicting case j,representing the probability that the label of case j is t under the condition that the classifier is v, wherein t is 1, 2.
Step 3.2: updating the prediction result:
wherein,representing the probability of the label of case j being t under the condition of classifier v after updating,a probability vector representing the updated classifier v prediction case j;
C(ta,tb) Indicates the label taAnd a label tbThe correlation of (a):
C(ta,tb)≠C(tb,ta)
wherein,representing simultaneous inclusion of labels t in a marked case setaAnd tbThe number of cases (a) of (b),representing only labels t in a marked case setbThe number of cases of (c);
step 3.3: calculating the global reliability of the prediction case j:
wherein Hv(j, t) represents the reliability of case j on label t:
step 3.4: performing descending order according to the global reliability, and selecting the first n cases as a reliable case set BvAnd transferring reliable case sets among the 3 classifiers, removing the reliable case sets from the corresponding unmarked case sets, adding the reliable case sets into the marked case sets to form new marked case sets, and using ML-The KNN method trains each classifier again on the new labeled case set;
step 3.5: repeating the steps 3.1-3.4 until the unmarked case set is empty; obtaining 3 final trained classifiers;
and 4, step 4: outputting an optimal classification result:
where α, β, γ are preset weights for classifiers 1,2, 3, respectively, and α + β + γ is 1.
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