CN111122464B - Constant temperature photocell assembly of 10 microliter serum iodine determinator - Google Patents
Constant temperature photocell assembly of 10 microliter serum iodine determinator Download PDFInfo
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- CN111122464B CN111122464B CN201911146909.7A CN201911146909A CN111122464B CN 111122464 B CN111122464 B CN 111122464B CN 201911146909 A CN201911146909 A CN 201911146909A CN 111122464 B CN111122464 B CN 111122464B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
Abstract
The invention provides a constant-temperature photocell component of a 10 microliter serum iodine determinator, wherein a detection tube hole is formed in the upper side of a light cell main part, an iodine detection light path penetrating left and right and a creatinine detection light path penetrating front and back are formed in the middle of the light cell main part, the iodine detection light path and the creatinine detection light path are perpendicular to each other and penetrate through the detection tube hole, a light source component and a first detection light component are installed on the iodine detection light path, and a light source component and a second detection light component are installed on the creatinine detection light path; and a temperature sensor is arranged on the left side of the optical cell main part, and a heating component is arranged on the lower side of the optical cell main part. The invention has compact structure, realizes the measurement of the ratio of the iodine content to the creatinine content; the hexagonal quartz measuring tube is beneficial to digestion of a serum sample, mixing of a measuring solution and passing of single-wavelength light; the heating assembly and the temperature sensor can detect dynamic catalytic reaction in the trace iodine determination process; 10 microliter of serum is used, the reagent amount is small, and the detection precision is not reduced; 2080 heating wire has low power, low thermal expansion deformation, and long service life.
Description
Technical Field
The invention relates to a constant-temperature photocell component of a 10-microliter serum iodine determinator, belonging to the field of clinical examination instruments.
Background
Currently, the photoelectric conversion part of the known iodine measuring instrument adopts a plurality of discrete component designs. The device mainly comprises a serum digestion tube, a detection pool, a monochromatic light generator, a colorimetric pool frame, a slit, a monochromatic light detector and a colorimetric pool temperature control unit. This structure has significant disadvantages: the integration degree is low, the structure dispersion is not compact, and the instrument volume is large. Therefore, a highly integrated constant temperature photoelectric conversion module applicable to a miniaturized iodine measuring instrument is in need of development.
Disclosure of Invention
The invention provides a constant-temperature photocell assembly of a 10 microliter serum iodine determinator, and aims to overcome the defects of the prior art, realize high integration of multiple components and effectively reduce the volume of the determinator.
In order to achieve the purpose, the invention adopts the technical scheme that:
a constant temperature photocell assembly of a 10 microliter serum iodine determinator is characterized in that a hexagonal detection tube hole is formed in the upper side of a light cell main part, and a hexagonal quartz measurement tube can be placed in the detection tube hole;
an iodine detection light path penetrating left and right and a creatinine detection light path penetrating front and back are arranged in the middle of the light cell main part, the iodine detection light path and the creatinine detection light path are perpendicular to each other and penetrate through the detection tube hole, a light source assembly is installed at the left end of the iodine detection light path, a first detection light assembly is installed at the right end of the iodine detection light path, a light source assembly is installed at the front end of the creatinine detection light path, and a second detection light assembly is installed at the rear end of the creatinine detection light path;
and a temperature sensor is arranged on the left side of the optical cell main part, and a heating component is arranged on the lower side of the optical cell main part.
The constant-temperature photocell component of the 10 microliter serum iodine determinator comprises: the light source component comprises a light emitting diode and a lamp sleeve jackscrew, wherein the light emitting diode is arranged in the lamp sleeve jackscrew, and the light emitting diode is fixed outside the lamp sleeve jackscrew.
The constant-temperature photocell component of the 10 microliter serum iodine determinator comprises: the first detection light assembly comprises a 460nm light filter, a black rubber pad, a photodiode pipe frame, a photodiode and a photoelectric circuit board, the 460nm light filter, the black rubber pad and the photoelectric circuit board are sequentially arranged from inside to outside, and pins of the photodiode are welded on the photoelectric circuit board after being inserted into the photodiode pipe frame.
The constant-temperature photocell component of the 10 microliter serum iodine determinator comprises: the second detection light assembly uses a 490nm filter, and other parts are the same as those of the first detection light assembly.
The constant-temperature photocell component of the 10 microliter serum iodine determinator comprises: the heating assembly comprises a mica insulation board, a heating plate and a heat insulation bottom plate, and the mica insulation board, the heating plate, the mica insulation board and the heat insulation bottom plate are sequentially arranged from top to bottom in the installation sequence.
The constant-temperature photocell component of the 10 microliter serum iodine determinator comprises: the heating plate is formed by winding 2080 heating wires on a mica sheet, and adopts pressure reduction proportion control when the temperature is close to the catalytic reaction temperature of 32 ℃.
The constant-temperature photocell component of the 10 microliter serum iodine determinator comprises: and a right end cover is installed at the right end of the optical cell main part.
Compared with the prior art, the invention has the beneficial effects that:
1. the hexagonal quartz measuring tube integrates the functions of a digestion tube and a detection pool, is favorable for digestion of a serum sample and mixing of a measurement solution when used as the digestion tube, and is also favorable for light with single wavelength to pass through when used as the detection pool;
2. the light cell main part can be integrally provided with a quartz measuring tube, a light source component, a first detection light component, a second detection light component, a heating component and a temperature sensor, so that the structure is more compact, and the space is saved;
3. the device is provided with a heating assembly and a temperature sensor, and can be used for detecting dynamic catalytic reaction in the determination process of trace iodine;
4. generally, 100 microliters of serum is used for measuring the serum iodine, 10 microliters of serum is used in the method, the reagent amount is small, and the detection precision is not reduced;
5. the bending length of the 2080 heating wire wound on the mica sheet is 6mm, and the decompression proportion is adopted for control when the temperature is close to 32 ℃ of catalytic reaction, so that the 2080 heating wire has small use power, small thermal expansion deformation and long service life.
Drawings
FIG. 1 is an assembly view of the thermostatic photocell assembly of the 10 microliter serum iodine tester provided by the present invention;
FIG. 2a is a front view of the cell main part;
FIG. 2b is a top view of the cell main part;
FIG. 3a is a front view of a quartz measurement tube;
FIG. 3b is a left side view of the quartz measurement tube;
FIG. 4 is a top view of the heating plate;
FIG. 5 is a schematic view of the light emitting assembly;
FIG. 6 is a schematic diagram of the composition of the iodine detection assembly;
FIG. 7a is a front view of the right end cap;
FIG. 7b is a left side view of the right end cap;
fig. 8 is a tube voltage detection circuit diagram.
Description of reference numerals: 1-a light cell master; 2-quartz measuring tube; 3-a light emitting diode; 4-the lamp sleeve is screwed; 5-460nm filter; 6-black rubber mat; 7-a photodiode; 8-photodiode rack; 9-a photoelectric circuit board; 10-right end cap; 11-mica insulation board; 12-a heating plate; 13-an insulating bottom plate; 14-measuring tube holes; 15-iodine detection optical path; 16-creatinine detection light path; 17-M5 threaded holes; 18-temperature sensor mounting holes; 19-M2 threaded holes; 20-M4 threaded holes; 21-winding holes; 22-2080 heating wires; 23-16 bit AD card.
Detailed Description
Some specific embodiments of the invention will be described in detail below, by way of example and not by way of limitation, with reference to the accompanying drawings. The same reference numbers in the drawings identify the same or similar elements or components. Those skilled in the art will appreciate that the drawings are not necessarily drawn to scale.
The invention provides a constant-temperature photocell assembly of a 10 microliter serum iodine determinator, which comprises an optical cell main part 1, a quartz measuring tube 2, a heating assembly, a light source assembly, a first detection light assembly, a second detection light assembly, a temperature sensor and a right end cover 10.
Referring to fig. 2a and 2b, the light cell main part 1 is a nylon rectangular body with a size of 40 × 40 × 30mm (length × width × height), and a regular hexagonal measuring tube hole 14 is formed on the upper surface of the light cell main part 1 for installing the quartz measuring tube 2. Two M5 threaded holes 17 are formed in the lower surface of the cell main body 1 for fixing the heating assembly. In the middle part of light cell main part 1, it is equipped with iodine detection light path 15 to run through light cell main part 1 left and right sides surface iodine detection light path 15's left end installation light source subassembly iodine detection light path 15's right-hand member installation first detection optical component. In the middle part of light cell main part 1, it is equipped with creatinine to run through light cell main part 1 front and back both sides surface and detect light path 16 creatinine the front end installation light source subassembly of creatinine detection light path 16 creatinine rear end installation second detection light subassembly of light path 16. The iodine detection pipeline and the creatinine detection optical path both penetrate through the measurement pipe hole 14.
And a temperature sensor mounting hole 18 is formed in the lower part of the left side surface of the light cell main part 1 and used for mounting a temperature sensor, and the temperature sensor mounting hole is positioned below the bottom of the measuring tube hole 14.
Preferably, two M2 screw holes 19 are formed in each of the right and rear surfaces of the cell main body 1 to fix the first and second sensing light elements.
Preferably, two M4 threaded holes 20 are provided on the right side surface of the light cell 1 for fixing the right end cap 10.
Referring to fig. 3a and 3b, the quartz measuring tube 2 is regular hexagon in shape and is made of quartz glass. The quartz measuring tube 2 is internally filled with the serum to be detected and is placed in a measuring tube hole 14 on the light cell main part 1.
Referring to fig. 1 and 4, the heating assembly includes two mica insulation plates 11, a heating plate 12 and an insulating bottom plate 13, and the mica insulation plates 11, the heating plate 12, the mica insulation plates 11 and the insulating bottom plate 14 are stacked in this order from top to bottom and mounted on the bottom of the light cell main part 1 by two M5 screws. The mica insulation plate 11 is made of mica sheets and plays an insulation role. The heating plate 12 is formed by arranging a plurality of rows of winding holes 21 on a mica sheet, and then winding 2080 heating wires 22 on the mica sheet through the winding holes 21. The heat insulation bottom plate 13 is made of polytetrafluoroethylene (F4) and is installed at the lowest layer to perform a heat insulation function.
Preferably, the length of the 2080 heating wire 22 wound on the mica sheet is 6 mm. In this example, 2080 heating wires 22 are wound in a manner that eight rows of winding holes are grouped into four groups, and 2080 heating wires 22 are wound in a zigzag manner in each group and connected across groups to the ends of the groups, and the winding directions of two adjacent groups are opposite. When the heating wire 22 of 2080 is close to the catalytic reaction temperature of 32 ℃, the pressure reduction ratio control is adopted.
Referring to fig. 1 and 5, the light source assembly includes a light emitting diode 3 and a lamp cap jackscrew 4, and the light emitting diode 3 is inserted into the left end of the iodine detection light path and the rear end of the creatinine detection light path to provide a light source. The lamp sleeve jackscrew 4 is a hexagon socket head cap screw with an axial through hole, and the light emitting diode 3 is screwed in the lamp sleeve jackscrew 4 to fix the light emitting diode 3 after the light emitting diode 3 is arranged in the iodine detection light path or the creatinine detection light path. The positive and negative electrodes of the light-emitting diode 3 can extend out of the axial through hole of the lamp sleeve jackscrew 4, so that wiring is facilitated.
Referring to fig. 1 and 6, the first detecting light assembly includes a 460nm filter 5, a black matrix 6, a photodiode 7, a photodiode frame 8, and a photoelectric circuit board 9. The first detection light assembly is arranged at the right end of the iodine detection light path 15, and the 460nm light filter 5, the black rubber pad 6 and the photoelectric circuit board 9 are arranged in sequence from inside to outside. The pins of the photodiode 7 are inserted into the photodiode holder 8 and then soldered to the photoelectric circuit board 9. The photoelectric circuit board 9 is fixed on the right side surface of the light cell main part 1 by two M2 screws.
The second detecting component and the first detecting component have similar compositions, and the difference is that the second detecting component uses a 490nm filter, and other parts are the same.
The temperature sensor is arranged in a temperature sensor mounting hole 18 at the lower part of the left side surface of the optical cell main part 1 and is used for being matched with the heating assembly to detect dynamic catalytic reaction in the trace iodine determination process. In this example, a Pt100 temperature sensor is selected.
Referring to fig. 1, 7a and 7b, the right end cap 10 is fastened to the outside of the optoelectronic circuit board 9 and is mounted on the right side surface of the light cell main part 1 by two M5 screws for protecting the optoelectronic circuit board 9.
Referring to fig. 8, in this example, a 16-bit AD card 23 is selected to implement the analog-to-digital conversion, the terminals No. 1 and No. 2 of the photoelectric circuit board 9 are electrically connected to the positive and negative electrodes of the light emitting diode 3 through cables, the terminals No. 3 and No. 4 are electrically connected to the terminals No. 8 and No. 1 of the 16-bit AD card 9 through cables, respectively, and the signal converted by the 16-bit AD card 9 is transmitted to the microcomputer through the USB interface.
It should be noted that the invention works with the support of software, the VB is adopted to write the software, the acquisition mode of absorbance is completed by calculation according to the logarithmic relation between light intensity and absorbance, an analog circuit scheme is not adopted to convert the light intensity into absorbance, and the light intensity acquisition and absorbance calculation program is completed by a deteminatedabsorbance.
The invention has the advantages that:
according to the invention, the quartz measuring tube, the light source component, the first detection light component, the second detection light component, the heating component and the temperature sensor are highly integrated through the light cell main component, so that the structure is more compact, the space is saved, and the ratio of the iodine content to the creatinine content is measured; the hexagonal quartz measuring tube is arranged, so that digestion of a serum sample, mixing of a measuring solution and passing of light with single wavelength are facilitated; a heating assembly and a temperature sensor are installed and used for detecting dynamic catalytic reaction in the trace iodine determination process; 10 microliter of serum is used, the reagent amount is small, and the detection precision is not reduced; 2080 hot wire has low power, low thermal expansion deformation and long service life.
The foregoing description is intended to be illustrative rather than limiting, and it will be appreciated by those skilled in the art that many modifications, variations or equivalents may be made without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (7)
1. A constant temperature photocell component of a 10 microliter serum iodine determinator is characterized in that: a hexagonal detection pipe hole is formed in the upper side of the light cell main part, and a hexagonal quartz measurement pipe can be placed in the detection pipe hole;
an iodine detection light path penetrating left and right and a creatinine detection light path penetrating front and back are arranged in the middle of the light cell main part, the iodine detection light path and the creatinine detection light path are perpendicular to each other and penetrate through the detection tube hole, a light source assembly is installed at the left end of the iodine detection light path, a first detection light assembly is installed at the right end of the iodine detection light path, a light source assembly is installed at the front end of the creatinine detection light path, and a second detection light assembly is installed at the rear end of the creatinine detection light path;
and a temperature sensor is arranged on the left side of the optical cell main part, and a heating component is arranged on the lower side of the optical cell main part.
2. The constant temperature photocell assembly of a 10 microliter serum iodine tester according to claim 1, wherein: the light source component comprises a light emitting diode and a lamp sleeve jackscrew, wherein the light emitting diode is arranged in the lamp sleeve jackscrew, and the light emitting diode is fixed outside the lamp sleeve jackscrew.
3. The constant temperature photocell assembly of a 10 microliter serum iodine tester according to claim 1, wherein: the first detection light assembly comprises a 460nm light filter, a black rubber pad, a photodiode pipe frame, a photodiode and a photoelectric circuit board, the 460nm light filter, the black rubber pad and the photoelectric circuit board are sequentially arranged from inside to outside, and pins of the photodiode are welded on the photoelectric circuit board after being inserted into the photodiode pipe frame.
4. The constant temperature photocell assembly of a 10 microliter serum iodine tester according to claim 3, wherein: the second detection light assembly uses a 490nm filter, and other parts are the same as those of the first detection light assembly.
5. The thermostatted photocell assembly of a 10-microliter serum iodine tester as claimed in claim 1, characterized in that: the heating assembly comprises a mica insulation board, a heating plate and a heat insulation bottom plate, and the mica insulation board, the heating plate, the mica insulation board and the heat insulation bottom plate are sequentially arranged from top to bottom in the installation sequence.
6. The constant temperature photocell assembly of a 10 microliter serum iodine tester according to claim 5, wherein: the heating plate is formed by winding 2080 heating wires on a mica sheet, and adopts pressure reduction proportion control when the temperature is close to the catalytic reaction temperature of 32 ℃.
7. The constant temperature photocell assembly of a 10 microliter serum iodine tester according to claim 1, wherein: and a right end cover is installed at the right end of the optical cell main part.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911146909.7A CN111122464B (en) | 2019-11-21 | 2019-11-21 | Constant temperature photocell assembly of 10 microliter serum iodine determinator |
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| CN201911146909.7A CN111122464B (en) | 2019-11-21 | 2019-11-21 | Constant temperature photocell assembly of 10 microliter serum iodine determinator |
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| CN111122464B true CN111122464B (en) | 2022-07-05 |
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| CA2743966A1 (en) * | 2011-04-15 | 2012-10-15 | Tutco, Inc. | Electrical resistance heater assembly and method of use |
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| CN106290181A (en) * | 2016-07-15 | 2017-01-04 | 哈尔滨医科大学 | A kind of iodine in serum quantitative determination reagent kit |
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2019
- 2019-11-21 CN CN201911146909.7A patent/CN111122464B/en active Active
Patent Citations (5)
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|---|---|---|---|---|
| JP2002196007A (en) * | 2000-12-25 | 2002-07-10 | Sysmex Corp | Liquid sample measuring unit and automatic liquid sample analyzer provided with this |
| CN201697872U (en) * | 2010-04-28 | 2011-01-05 | 成都市信达温度测控技术有限公司 | Urinary iodine tester |
| CA2743966A1 (en) * | 2011-04-15 | 2012-10-15 | Tutco, Inc. | Electrical resistance heater assembly and method of use |
| CN104345053A (en) * | 2014-10-11 | 2015-02-11 | 汕头大学 | Gold nanoparticle biological sensor for detecting serum creatinine and preparation method of gold nanoparticles biological sensor |
| CN106290181A (en) * | 2016-07-15 | 2017-01-04 | 哈尔滨医科大学 | A kind of iodine in serum quantitative determination reagent kit |
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| Title |
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