CN111121396A - Freeze-drying equipment is used in production of immunoglobulin oral freeze-drying preparation - Google Patents
Freeze-drying equipment is used in production of immunoglobulin oral freeze-drying preparation Download PDFInfo
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- CN111121396A CN111121396A CN201911355398.XA CN201911355398A CN111121396A CN 111121396 A CN111121396 A CN 111121396A CN 201911355398 A CN201911355398 A CN 201911355398A CN 111121396 A CN111121396 A CN 111121396A
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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Abstract
The invention discloses a freeze-drying device for producing an immunoglobulin oral freeze-drying preparation, which comprises a tank body assembly, a rotating assembly, a heating assembly and a material receiving assembly, wherein the tank body assembly comprises a supporting seat, a drying tank, a vacuumizing pipe, a steam exhaust pipe, a first electric push rod and a door plate, the rotating assembly comprises a speed reducing motor, a driving shaft, a connecting block and a bearing tank, the heating assembly comprises an oil pump, a heat exchange pipe, a sleeve and a rotating disc, and the material receiving assembly comprises a material collecting box, a second electric push rod, a brush and a material guide pipe. The invention provides a drying space through the tank body assembly; placing the frozen immune protein ball stock solution in a bearing tank, and driving the bearing tank to rotate through the operation of a speed reducing motor, so that the rotation of the material is realized, and the subsequent drying is facilitated; heating through heating element, avoid appearing sublimating in-process material temperature drop to with drying chamber steam partial pressure phase equilibrium's temperature and influence the sublimation.
Description
Technical Field
The invention relates to the technical field of immune protein freeze-drying, in particular to freeze-drying equipment for producing an immunoglobulin oral freeze-dried preparation.
Background
The immunoglobulin is a kind of immune active molecules, and the immune active molecules comprise immune cell membrane molecules, such as antigen recognition receptors, differentiation antigens, major histocompatibility molecules and some other receptor molecules; also included are molecules synthesized and secreted by immune and non-immune cells, such as immunoglobulin molecules, complement molecules, cytokines, etc., which are chemical structural concepts, and the chemical basis of all antibodies is an immunoglobulin, but immunoglobulins do not all have antibody activity.
Freeze-drying, which is short for vacuum freeze-drying technology, is a novel drying means that a water-containing material is frozen into a solid, the sublimation performance of water is utilized under the conditions of low temperature and low pressure to dehydrate the material at low temperature so as to dry the material, as the vacuum freeze-drying technology is carried out in a low-temperature and low-oxygen environment, most biological reactions are stagnated, the novel box body structure is pushed out, the space for storing materials in the box body is greatly utilized to carry out freeze vacuum drying for drying, and freeze drying is widely applied to the production of immune globulin.
Current refrigeration plant is freezing at the in-process in use earlier stoste immunoglobulin, then places the stoste after freezing on the loading board of drying cabinet, utilizes the outlying vacuum pumping system of drying cabinet and inside heating device to dry, and the material is unable when the inside of drying cabinet moves, and this just leads to in actual use, generally all sets up the sublimation from the upper portion of the stoste after freezing, is unfavorable for drying.
Disclosure of Invention
The invention aims to provide freeze-drying equipment for producing an immunoglobulin oral freeze-drying preparation, wherein a drying space is provided through a tank body assembly, frozen immune protein ball stock solution is placed in a bearing tank, the bearing tank is driven to rotate through the operation of a speed reduction motor, the rotation of materials is realized, the subsequent drying is facilitated, the heating assembly is used for heating, the sublimation is prevented from being influenced by the fact that the temperature of the materials is reduced to the temperature balanced with the steam partial pressure of a drying chamber in the sublimation process, and the problems in the background art are solved.
In order to achieve the purpose, the invention provides the following technical scheme: a freeze-drying device for producing immunoglobulin oral freeze-dried preparation comprises:
the tank body assembly comprises a supporting seat, a drying tank, a vacuumizing pipe, a steam exhaust pipe, a first electric push rod and a door plate, wherein the drying tank is installed on the upper portion of the supporting seat through a frame body, the vacuumizing pipe and the steam exhaust pipe are both arranged on the side portion of the drying tank, the door plate is hinged to the side portion of the drying tank through a hinge, the first electric push rod is fixedly installed on the outer side of the drying tank through a bolt, the output end of the first electric push rod is hinged to the side portion of the door plate, the upper portion of the drying tank is installed on a vacuum pump, and the air inlet end of the vacuum pump is communicated with the;
the drying device comprises a rotating assembly, the rotating assembly comprises a speed reducing motor, a driving shaft, a connecting block and a bearing tank, the speed reducing motor is mounted on the side portion of a drying tank through a motor base, the driving shaft is mounted at the output end of the speed reducing motor through a coupler, the driving shaft penetrates through the side wall of the drying tank and extends into the drying tank, the connecting block is mounted at the end portion of the driving shaft through a bolt, a mounting hole is formed in the inner side of the connecting block, an internal thread section is arranged on the inner wall, close to the mounting hole, of the connecting block, a threaded pipe is mounted at one end of the bearing tank, the other end of the bearing tank is communicated with an extension pipe, an external thread section matched with the internal thread section is arranged on the outer side of the threaded pipe, the threaded pipe is connected with the connecting block through;
the heating assembly comprises an oil pump, a heat exchange tube, a sleeve and a rotating disc, the oil pump is fixedly mounted on the side portion of the drying tank through an oil pump seat, the sleeve is communicated with the side portion, close to the oil pump, of the drying tank, the sleeve extends to the inside of the drying tank in an extending mode, the end portion of the sleeve is rotatably connected with the rotating disc through a bearing, the inside of the sleeve is divided into a first containing cavity and a second containing cavity through a heat insulation plate, an oil inlet tube and an oil outlet tube are mounted inside the first containing cavity and the second containing cavity respectively, the oil inlet tube and the oil outlet tube penetrate through the middle portion of the rotating disc and are communicated with the oil inlet end and the oil outlet end of the heat exchange tube respectively, the oil inlet end of the oil inlet tube is hermetically connected with the oil outlet end of the oil pump, the heat exchange tube extends into the bearing tank through the extending tube;
and receive the material subassembly, receive the material subassembly including collection case, second electric putter, brush and passage, the collection case passes through screw fixed mounting in the inside of drying cylinder, the upper portion of collection case is relative with the lower part that bears the jar, second electric putter installs in the lateral part of collection case, the brush passes through the bolt and installs in second electric putter's output, the brush hair of brush is inconsistent with the inner wall of collection case, passage sealing connection keeps away from second electric putter's lower side portion in collection case, the passage runs through the lower wall of drying cylinder and extends to the outside of drying cylinder.
Preferably, the lateral part that the drying cylinder closes on gear motor installs with drive shaft complex bearing, the lateral part of drying cylinder offer with door plant complex breach, the position that the drying cylinder closes on the breach is glued and is had the sealing strip.
Preferably, the upper portion side cross-section of support body is the arc setting, install the bracing through the bolt between the lateral part of support body and the last lateral part of supporting seat, the storage case has been placed on the upper portion of supporting seat, the upper portion of storage case and the lower part intercommunication of passage.
Preferably, the central line of the driving shaft, the central line of the connecting block, the central line of the bearing tank and the central line of the sleeve are all coaxially arranged, and the bearing tank, the threaded pipe and the extension pipe are of an integral structure.
Preferably, the screwing direction of the internal thread section and the external thread section is opposite to the rotating direction of the driving shaft, and the end part of the internal thread section close to the connecting block is hinged with a sealing ring.
Preferably, the side part of the rotating disc opposite to the epitaxial tube is hinged with an elastic rubber pad, and a groove matched with the epitaxial tube is formed in the side part of the elastic rubber pad.
Preferably, the heat insulation plate is a rock wool heat insulation plate or a rock wool heat insulation plate.
Preferably, the side view cross section of the material collecting box is arc-shaped, the material collecting box inclines by 10-15 degrees towards the material guide pipe, and the middle part of the material guide pipe is provided with an electric gate valve.
In summary, due to the adoption of the technology, the invention has the beneficial effects that:
according to the invention, a drying space is provided by the drying tank, the drying tank is supported by the matching of the supporting seat and the frame body, the interior of the drying tank is sucked by the matching of the vacuum pump and the vacuumizing tube, a certain vacuum degree is maintained in the drying tank, the door plate can be opened and closed by the operation of the first electric push rod, the bearing tank is conveniently placed in the drying tank, and the operation and the use are convenient.
According to the invention, the frozen immune protein ball stock solution is placed in the bearing tank, then the bearing tank is installed by utilizing the matching of the internal thread section and the external thread section, the sealing is carried out under the matching of the sealing ring, the extension pipe at the side part of the bearing tank is enabled to be abutted against the elastic rubber pad at the side part of the rotating disc, the bearing tank is simply and conveniently installed, the bearing tank can be driven to rotate by the operation of the speed reducing motor, the material is driven to rotate, the simultaneous sublimation in multiple directions is realized, and the drying is convenient.
According to the invention, when the temperature of the material is reduced to be balanced with the steam partial pressure of the drying tank, external hot heat conduction oil is introduced into the heat exchange tube through the oil pump through the oil inlet tube, the material is heated by the heat exchange tube, so that the sublimation process is continued, the material is heated well, the effective rotation of the bearing tank is ensured through the matching of the rotating disc, the elastic rubber pad and the extension tube, the heat conduction oil after heat exchange is discharged through the oil outlet tube, the oil inlet tube and the oil outlet tube are insulated through the heat insulation plate, the good heat dissipation effect is integrally achieved, and the continuous sublimation is facilitated.
According to the invention, the dried material falls into the material collecting box through the through hole, the second electric push rod is operated, the second electric push rod drives the hairbrush to move to scrape the interior of the material collecting box, the dried material is scraped and brushed to the material guide pipe and is stored through the material storage box, and the finished material is convenient to collect.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is a schematic sectional view of a freeze-drying apparatus for producing an immunoglobulin oral freeze-dried preparation according to the present invention;
FIG. 2 is a schematic enlarged sectional view of a part of the structure of a carrying tank of a freeze-drying apparatus for producing an immunoglobulin oral freeze-dried preparation according to the present invention;
FIG. 3 is a schematic sectional view of a sleeve portion of a freeze-drying apparatus for producing an immunoglobulin oral freeze-dried preparation according to the present invention;
FIG. 4 is a schematic diagram of a freeze-drying apparatus for producing an immunoglobulin oral freeze-dried preparation according to the present invention, which is partially shown in a cross-sectional side view and enlarged in a cross-sectional view;
FIG. 5 is a schematic side sectional view showing an enlarged structure of a sleeve portion of a freeze-drying apparatus for producing an immunoglobulin oral freeze-dried preparation of the present invention;
FIG. 6 is a schematic diagram of the elastic rubber pad of the freeze-drying device for producing the immunoglobulin oral freeze-dried preparation of the present invention, which is partially shown in cross-sectional side view and enlarged in structure.
In the figure: 1. a canister assembly; 101. a supporting seat; 102. a drying tank; 103. vacuumizing a tube; 104. a steam rack pipe; 105. a first electric push rod; 106. a door panel; 107. a frame body; 108. a vacuum pump; 2. a rotating assembly; 201. a reduction motor; 202. a drive shaft; 203. connecting blocks; 204. a carrying tank; 205. mounting holes; 206. an internal thread section; 207. a threaded pipe; 208. an extension tube; 209. an external threaded section; 210. a through hole; 3. a heating assembly; 301. an oil pump; 302. a heat exchange pipe; 303. a sleeve; 304. rotating the disc; 305. a heat insulation plate; 306. a first cavity; 307. a second cavity; 308. an oil inlet pipe; 309. an oil outlet pipe; 4. a material receiving assembly; 401. a material collecting box; 402. a second electric push rod; 403. a brush; 404. a material guide pipe; 5. a notch; 6. a sealing strip; 7. bracing; 8. a material storage box; 9. a seal ring; 10. an elastic rubber pad; 11. a groove; 12. electric gate valve.
The implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings of the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present invention, it is to be understood that the terms "longitudinal", "upper", "lower", "left", "right", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are used only for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
The present invention provides a freeze-drying apparatus for the production of an immunoglobulin oral freeze-dried preparation as shown in fig. 1 to 6, comprising: tank assembly 1, tank assembly 1 includes a support base 101, a drying tank 102, a vacuumizing pipe 103, a steam exhaust pipe 104, a first electric push rod 105 and a door plate 106, drying tank 102 is installed on the upper portion of support base 101 through a frame body 107, the upper side cross-section of frame body 107 is arc-shaped, a diagonal brace 7 is installed between the side portion of frame body 107 and the upper side portion of support base 101 through a bolt, a storage box 8 is placed on the upper portion of support base 101, the upper portion of storage box 8 is communicated with the lower portion of a material guide pipe 404, vacuumizing pipe 103 and steam exhaust pipe 104 are both opened on the side portion of drying tank 102, door plate 106 is hinged on the side portion of drying tank 102 through a hinge, first electric push rod 105 is fixedly installed on the outer side of drying tank 102 through a bolt, the output end of first electric push rod 105 is hinged on the side portion of door plate 106, the upper portion of drying tank 102, a bearing matched with the driving shaft 202 is installed on the side part of the drying tank 102 close to the speed reducing motor 201, a notch 5 matched with the door plate 106 is formed in the side part of the drying tank 102, and a sealing strip 6 is glued to the part of the drying tank 102 close to the notch 5;
referring to fig. 1 and 2, the rotating assembly 2 includes a reduction motor 201, a driving shaft 202, a connecting block 203 and a bearing tank 204, the reduction motor 201 is mounted on a side portion of the drying tank 102 through a motor base, the driving shaft 202 is mounted on an output end of the reduction motor 201 through a coupling, the driving shaft 202 penetrates through a side wall of the drying tank 102 and extends into the drying tank 102, the connecting block 203 is mounted on an end portion of the driving shaft 202 through bolts, a mounting hole 205 is formed in an inner side of the connecting block 203, an inner threaded section 206 is disposed on an inner wall of the connecting block 203 adjacent to the mounting hole 205, a threaded pipe 207 is mounted at one end of the bearing tank 204, an outer extended pipe 208 is communicated with another end of the bearing tank 204, an outer threaded section 209 matched with the inner threaded section 206 is disposed on an outer side of the threaded pipe 207, a screwing direction of the inner threaded section 206 and the outer threaded section 209 is opposite to a, the threaded pipe 207 is connected with the connecting block 203 through the matching of the internal threaded section 206 and the external threaded section 209, the side wall of the bearing tank 204 is uniformly provided with a plurality of through holes 210 at equal intervals, the central line of the driving shaft 202, the central line of the connecting block 203, the central line of the bearing tank 204 and the central line of the sleeve pipe 303 are coaxially arranged, and the bearing tank 204, the threaded pipe 207 and the extension pipe 208 are of an integral structure;
referring to fig. 1, 3, 5 and 6, a heating assembly 3 includes an oil pump 301, a heat exchange tube 302, a sleeve 303 and a rotary disc 304, the oil pump 301 is fixedly mounted on a side portion of the drying tank 102 through an oil pump seat, the sleeve 303 is communicated with a side portion of the drying tank 102 adjacent to the oil pump 301, the sleeve 303 extends to the inside of the drying tank 102, an end portion of the sleeve 303 is rotatably connected with the rotary disc 304 through a bearing, an elastic rubber pad 10 is hinged to a side portion of the rotary disc 304 opposite to the extension tube 208, a groove 11 matched with the extension tube 208 is formed on a side portion of the elastic rubber pad 10, the inside of the sleeve 303 is divided into a first cavity 306 and a second cavity 307 through a heat insulation plate 305, the first cavity 306 and the second cavity 307 are rock wool heat insulation plates or rock wool heat insulation plates, an oil inlet tube 308 and an oil outlet tube 309 are respectively mounted inside the first cavity 306 and the second cavity 307, the oil inlet tube 308 and the oil outlet tube 309, the oil inlet end of the oil inlet pipe 308 is hermetically connected with the oil outlet end of the oil pump 301, the heat exchange pipe 302 extends into the bearing tank 204 through the extension pipe 208, and the end part of the extension pipe 208 is abutted against the side part of the rotating disc 304;
referring to fig. 1 and 4, and the material collecting assembly 4, the material collecting assembly 4 includes a material collecting box 401, a second electric push rod 402, a brush 403 and a material guiding pipe 404, the material collecting box 401 is fixedly installed inside the drying tank 102 through screws, the upper portion of the material collecting box 401 is opposite to the lower portion of the carrying tank 204, the second electric push rod 402 is installed at the side portion of the material collecting box 401, the brush 403 is installed at the output end of the second electric push rod 402 through bolts, bristles of the brush 403 are abutted against the inner wall of the material collecting box 401, the material guiding pipe 404 is hermetically connected to the lower side portion of the material collecting box 401 far away from the second electric push rod 402, the material guiding pipe 404 penetrates through the lower wall of the drying tank 102 and extends to the outside of the drying tank 102, the side view cross section of the material collecting box 401 is arc-shaped, the material collecting box 401 is inclined towards the material.
The working principle is as follows: when the drying device is used, a drying space is provided through the drying tank 102, the drying tank 102 is supported through the matching of the supporting seat 101 and the frame body 107, the inside of the drying tank 102 is sucked through the matching of the vacuum pump 108 and the vacuumizing pipe 103, a certain vacuum degree is maintained in the drying tank 102, the door plate 106 can be opened and closed through the operation of the first electric push rod 105, the bearing tank 204 is conveniently placed in the drying tank 102, and the operation and the use are convenient;
the frozen immune protein ball stock solution is placed in the bearing tank 204, then the bearing tank 204 is installed by utilizing the matching of the internal thread section 206 and the external thread section 209, sealing is carried out under the matching of the sealing ring 9, the extension pipe at the side part of the bearing tank 204 is enabled to be abutted against the elastic rubber pad 10 at the side part of the rotating disc 304, the bearing tank is simply and conveniently installed, the bearing tank 204 can be driven to rotate by the running of the speed reducing motor, further the material is driven to rotate, the simultaneous sublimation in multiple directions is realized, and drying is facilitated;
when the temperature of the material is reduced to be balanced with the steam partial pressure of the drying tank 102, external hot heat conduction oil is introduced into the heat exchange tube 302 through the oil inlet tube 308 through the oil pump 301, the material is heated by the heat exchange tube 302, so that the sublimation process is continued, the material is heated well, the effective rotation of the bearing tank 204 is ensured through the matching of the rotating disc 304, the elastic rubber pad 10 and the extension tube 208, the heat conduction oil after heat exchange is discharged through the oil outlet tube 309, the oil inlet tube 308 and the oil outlet tube 309 are insulated through the heat insulation plate 305, the good heat dissipation effect is integrally achieved, and the continuous sublimation is facilitated;
the dried material falls into the inside of case 401 through-hole 210, and operation second electric putter 402, second electric putter 402 drive brush 403 and remove and scrape the brush to the inside of case 401 that gathers materials, scrape the dried material and brush guide pipe 404 to save through storage case 8, the collection of the finished product material of being convenient for.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. A freeze-drying equipment for producing immunoglobulin oral freeze-dried preparation is characterized by comprising:
the tank assembly (1) comprises a supporting seat (101), a drying tank (102), a vacuumizing pipe (103), a steam exhaust pipe (104), a first electric push rod (105) and a door plate (106), wherein the drying tank (102) is installed on the upper portion of the supporting seat (101) through a frame body (107), the vacuumizing pipe (103) and the steam exhaust pipe (104) are both arranged on the side portion of the drying tank (102), the door plate (106) is hinged to the side portion of the drying tank (102) through a hinge, the first electric push rod (105) is fixedly installed on the outer side of the drying tank (102) through a bolt, the output end of the first electric push rod (105) is hinged to the side portion of the door plate (106), the upper portion of the drying tank (102) is installed on a vacuum pump (108), and the air inlet end of the vacuum pump (108) is communicated with the vacuumizing pipe (103) in a sealing mode;
the rotary component (2), the rotary component (2) comprises a speed reducing motor (201), a driving shaft (202), a connecting block (203) and a bearing tank (204), the speed reducing motor (201) is installed on the side portion of the drying tank (102) through a motor base, the driving shaft (202) is installed at the output end of the speed reducing motor (201) through a coupler, the driving shaft (202) penetrates through the side wall of the drying tank (102) and extends into the drying tank (102), the connecting block (203) is installed at the end portion of the driving shaft (202) through a bolt, an installation hole (205) is formed in the inner side of the connecting block (203), an inner thread section (206) is arranged on the inner wall, close to the installation hole (205), of the connecting block (203), a threaded pipe (207) is installed at one end of the bearing tank (204), an outer extension pipe (208) is communicated with the other end of the bearing tank (204), and an outer thread section (209) matched with the inner thread section (206, the threaded pipe (207) is connected with the connecting block (203) through the matching of an internal thread section (206) and an external thread section (209), and a plurality of through holes (210) are uniformly arranged on the side wall of the bearing tank (204) at equal intervals;
heating element (3), heating element (3) includes oil pump (301), heat exchange tube (302), sleeve pipe (303) and rolling disc (304), oil pump (301) passes through oil pump seat fixed mounting in the lateral part of drying can (102), sleeve pipe (303) communicate in drying can (102) near the lateral part of oil pump (301), sleeve pipe (303) are outside to the inside of drying can (102), the tip of sleeve pipe (303) passes through bearing and rolling disc (304) and rotates and link to each other, the inside of sleeve pipe (303) is split into first appearance chamber (306) and second appearance chamber (307) through heat insulating board (305), oil inlet pipe (308) and play oil pipe (309) are installed respectively to the inside that first appearance chamber (306) and second appearance chamber (307), oil inlet pipe (308) and play oil pipe (309) all run through the middle part of rolling disc (304) and respectively communicate with the oil inlet end and the play oil end of heat exchange tube (302), the oil inlet end of the oil inlet pipe (308) is hermetically connected with the oil outlet end of the oil pump (301), the heat exchange pipe (302) extends into the bearing tank (204) through the extension pipe (208), and the end part of the extension pipe (208) is abutted against the side part of the rotating disc (304);
and receive material subassembly (4), receive material subassembly (4) including collection case (401), second electric putter (402), brush (403) and passage (404), collection case (401) are through screw fixed mounting in the inside of drying cylinder (102), the upper portion of collection case (401) is relative with the lower part that bears jar (204), second electric putter (402) are installed in the lateral part of collection case (401), brush (403) are installed in the output of second electric putter (402) through the bolt, the brush hair of brush (403) is inconsistent with the inner wall of collection case (401), lower side portion of second electric putter (402) is kept away from in collection case (401) to passage (404) sealing connection, passage (404) run through the lower wall of drying cylinder (102) and extend to the outside of drying cylinder (102).
2. The lyophilization apparatus for immunoglobulin oral lyophilized formulation production according to claim 1, wherein: the lateral part that desiccator (102) are close to gear motor (201) is installed and is had drive shaft (202) complex bearing, breach (5) with door plant (106) complex are seted up to the lateral part of desiccator (102), the position that desiccator (102) are close to breach (5) is glued and is had sealing strip (6).
3. The lyophilization apparatus for immunoglobulin oral lyophilized formulation production according to claim 1, wherein: the upper portion side cross-section of support body (107) is the arc setting, install bracing (7) through the bolt between the lateral part of support body (107) and the upside portion of supporting seat (101), storage case (8) have been placed on the upper portion of supporting seat (101), the upper portion of storage case (8) and the lower part intercommunication of passage (404).
4. The lyophilization apparatus for immunoglobulin oral lyophilized formulation production according to claim 1, wherein: the center line of the driving shaft (202), the center line of the connecting block (203), the center line of the bearing tank (204) and the center line of the sleeve (303) are coaxially arranged, and the bearing tank (204), the threaded pipe (207) and the extension pipe (208) are of an integral structure.
5. The lyophilization apparatus for immunoglobulin oral lyophilized formulation production according to claim 1, wherein: the screwing direction of the internal thread section (206) and the external thread section (209) is opposite to the rotating direction of the driving shaft (202), and the end part of the internal thread section (206) close to the connecting block (203) is hinged with a sealing ring (9).
6. The lyophilization apparatus for immunoglobulin oral lyophilized formulation production according to claim 1, wherein: the side part of the rotating disc (304) opposite to the extension tube (208) is hinged with an elastic rubber pad (10), and a groove (11) matched with the extension tube (208) is formed in the side part of the elastic rubber pad (10).
7. The lyophilization apparatus for immunoglobulin oral lyophilized formulation production according to claim 1, wherein: the heat insulation plate (305) is a rock wool heat insulation plate or a rock wool heat insulation plate.
8. The lyophilization apparatus for immunoglobulin oral lyophilized formulation production according to claim 1, wherein: the side view cross-section of the material collecting box (401) is arc-shaped, the material collecting box (401) inclines by 10-15 degrees towards the material guide pipe (404), and the middle part of the material guide pipe (404) is provided with an electric gate valve (12).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911355398.XA CN111121396B (en) | 2019-12-25 | 2019-12-25 | Freeze-drying equipment is used in production of immunoglobulin oral freeze-drying preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911355398.XA CN111121396B (en) | 2019-12-25 | 2019-12-25 | Freeze-drying equipment is used in production of immunoglobulin oral freeze-drying preparation |
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| CN111121396A true CN111121396A (en) | 2020-05-08 |
| CN111121396B CN111121396B (en) | 2021-09-10 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN205228039U (en) * | 2015-11-17 | 2016-05-11 | 上海东富龙科技股份有限公司 | Spraying freeze -drying equipment is with adding hot drying device |
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| CN205228039U (en) * | 2015-11-17 | 2016-05-11 | 上海东富龙科技股份有限公司 | Spraying freeze -drying equipment is with adding hot drying device |
| US20180321185A1 (en) * | 2017-05-02 | 2018-11-08 | Centaur Analytics, Inc. | Wireless sensor devices for post-harvest crop quality and pest management |
| CN207132669U (en) * | 2017-05-09 | 2018-03-23 | 蔡志挺 | A kind of Chinese medicine drum-type low temperature drying device |
| CN208525459U (en) * | 2017-07-24 | 2019-02-22 | 贵州师范学院 | A kind of Medical appliance decontaminating apparatus with functions/drying |
| CN207487302U (en) * | 2017-10-11 | 2018-06-12 | 商洛学院 | A kind of jerusalem artichoke extract drying device |
| CN208810159U (en) * | 2018-07-24 | 2019-05-03 | 潘秀文 | A kind of Chinese medicine processing grinding device |
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Denomination of invention: A freeze-drying equipment for the production of immunoglobulin oral freeze-drying preparation Effective date of registration: 20211223 Granted publication date: 20210910 Pledgee: China Construction Bank Corporation Taizhou pharmaceutical high tech Zone sub branch Pledgor: JIANGSU HUAGUAN BIOTECHNOLOGY JOINT STOCK CO.,LTD. Registration number: Y2021980016113 |
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