CN111110927B - Process for adding hydrophilic coating on surface of vascular sheath - Google Patents
Process for adding hydrophilic coating on surface of vascular sheath Download PDFInfo
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- CN111110927B CN111110927B CN201911388958.1A CN201911388958A CN111110927B CN 111110927 B CN111110927 B CN 111110927B CN 201911388958 A CN201911388958 A CN 201911388958A CN 111110927 B CN111110927 B CN 111110927B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C1/00—Apparatus in which liquid or other fluent material is applied to the surface of the work by contact with a member carrying the liquid or other fluent material, e.g. a porous member loaded with a liquid to be applied as a coating
- B05C1/02—Apparatus in which liquid or other fluent material is applied to the surface of the work by contact with a member carrying the liquid or other fluent material, e.g. a porous member loaded with a liquid to be applied as a coating for applying liquid or other fluent material to separate articles
- B05C1/022—Apparatus in which liquid or other fluent material is applied to the surface of the work by contact with a member carrying the liquid or other fluent material, e.g. a porous member loaded with a liquid to be applied as a coating for applying liquid or other fluent material to separate articles to the outer surface of hollow articles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C13/00—Means for manipulating or holding work, e.g. for separate articles
- B05C13/02—Means for manipulating or holding work, e.g. for separate articles for particular articles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C9/00—Apparatus or plant for applying liquid or other fluent material to surfaces by means not covered by any preceding group, or in which the means of applying the liquid or other fluent material is not important
- B05C9/08—Apparatus or plant for applying liquid or other fluent material to surfaces by means not covered by any preceding group, or in which the means of applying the liquid or other fluent material is not important for applying liquid or other fluent material and performing an auxiliary operation
- B05C9/12—Apparatus or plant for applying liquid or other fluent material to surfaces by means not covered by any preceding group, or in which the means of applying the liquid or other fluent material is not important for applying liquid or other fluent material and performing an auxiliary operation the auxiliary operation being performed after the application
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/28—Processes for applying liquids or other fluent materials performed by transfer from the surfaces of elements carrying the liquid or other fluent material, e.g. brushes, pads, rollers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/002—Pretreatement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D2502/00—Acrylic polymers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D2505/00—Polyamides
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D2518/00—Other type of polymers
Abstract
The invention discloses a process for adding a hydrophilic coating on the surface of a vascular sheath, which belongs to the technical field of medical treatment, and adopts N-vinyl pyrrolidone as a hydrophilic lubricating group, and adds a hydrophilic polymer, a polyurethane adhesive, a water-based cross-linking agent and an active diluent to effectively realize polymer chain polymerization, so that the cross-linking and curing are realized to form a net structure, the coating has adhesive force with certain strength, meanwhile, the surface of the vascular sheath is treated by a coupling agent, the surface of the vascular sheath has the characteristic of being fused with the hydrophilic coating under the condition of not influencing the structural strength of the vascular sheath after the outer layer material of the vascular sheath is subjected to molecular recombination treatment, finally, the hydrophilic coating is coated on the outer surface of the vascular sheath by using special equipment, the hydrophilic coating is uniformly coated on the vascular sheath in the rotating motion process of the vascular sheath, so that the smoothness of the outer surface of the vascular sheath is effectively improved, the puncture needle has the advantages that large friction force cannot be generated during clinical puncture, and the pain of a patient is greatly relieved.
Description
Technical Field
The invention relates to the technical field of medical treatment, in particular to a process for adding a hydrophilic coating on the surface of a vascular sheath.
Background
The minimally invasive interventional operation is to use interventional instruments such as a catheter, a bracket and the like to complete the treatment of pathological changes in a blood vessel or a cavity under the guidance of various imaging devices, and the implementation of the minimally invasive interventional treatment depends on various minimally invasive interventional medical instruments, wherein a blood vessel sheath is a necessary instrument in the treatment scheme and is placed on the skin and one part in the blood vessel to form a passage from the skin to the blood vessel, so that other PTCA surgical instruments, such as a guide catheter, can smoothly enter the blood vessel.
Wherein, the vascular sheath belongs to the appurtenance that the operation was intervene to the wicresoft, can not the error in the use, otherwise can influence going on of operation, and current vascular sheath surface smoothness is lower, because vascular sheath and skin, blood vessel direct contact, when its surface is not smooth, great frictional force during clinical use puncture, just can increase patient's misery.
In order to realize the coating with the lubricating function, the prepared coating has certain lubricity and hydrophilicity, the vascular sheath on the market is limited to the inert material of the vascular sheath material at present, the effect of directly coating the hydrophilic coating on the surface of the substrate is poor, and the adsorption force and the durability effect of the coating are poor; in addition, the coating process in the prior art generally comprises directly immersing the medical device in the hydrophilic coating or coating the medical device by spraying. For the tubular structure, the coating uniformity of the traditional coating process is still to be improved, if the coating is too much, the undried coating is easy to be condensed at the bottom end of the vascular sheath, so that the smoothness of the coating on the surface of the vascular sheath is poor, and the smooth effect of coating cannot be achieved.
Disclosure of Invention
1. Technical problem to be solved
Aiming at the problems in the prior art, the invention aims to provide a process for adding a hydrophilic coating on the surface of a vascular sheath, the surface of the vascular sheath has the characteristic of fusion with the hydrophilic coating under the condition of not influencing the structural strength of the vascular sheath after molecular recombination treatment is carried out on an outer layer material of the vascular sheath, and the surface of the vascular sheath obtains a special lubricating characteristic after hydrophilic agent is coated on the surface of the vascular sheath by coating equipment for curing.
2. Technical scheme
In order to solve the above problems, the present invention adopts the following technical solutions.
The process for adding the hydrophilic coating on the surface of the vascular sheath specifically comprises the following steps:
s1, preparation of hydrophilic coating raw materials: 55-80 parts of N-vinyl pyrrolidone serving as a hydrophilic lubricating component is placed in an ultrasonic reaction kettle, 10-15 parts of hydrophilic polymer, 3-6 parts of polyurethane adhesive, 3-5 parts of photoinitiator, 1-2 parts of active diluent, 0.5-1.5 parts of physical resistance reducing agent, 2-3 parts of water-based cross-linking agent, 0.5-1 part of antibacterial agent and 0.6-0.9 part of flatting agent are added in the ultrasonic reaction kettle, and the raw materials are mixed and stirred to prepare a hydrophilic coating raw material;
s2, surface treatment of vascular sheath: placing the vascular sheath in an ethanol solution for ultrasonic washing to remove dust and stains on the vascular sheath, washing the vascular sheath by pure water after ultrasonic washing to remove the ethanol solution on the vascular sheath, placing the washed vascular sheath in pure water at 30-37 ℃ for soaking for 2-4d, taking out and carrying out irradiation drying by using an ultraviolet lamp at 25-35 ℃ after soaking is finished, finally soaking the dried vascular sheath in a coupling agent, taking out after uniform soaking and carrying out irradiation drying again by using the ultraviolet lamp at 25-35 ℃ for later use;
s3, carrying out surface hydrophilic coating on the vascular sheath: connecting an ultrasonic reaction kettle with coating equipment through a communicating pipe, wherein a pump body is fixedly arranged on the communicating pipe, the ultrasonic reaction kettle conveys hydrophilic coating raw materials into the coating equipment through the communicating pipe, the vascular sheath rotates to pass through the hydrophilic coating raw materials in the coating equipment, and the hydrophilic coating raw materials are uniformly coated on the outer surface of the vascular sheath;
s4, drying the coating: the vessel sheath coated with the hydrophilic coating raw material moves to and is arranged in drying equipment on one side of the coating equipment, so that the drying treatment of the coating is realized, and the operation of adding the hydrophilic coating on the surface of the vessel sheath is completed after the drying is completed.
Further, the hydrophilic polymer in S1 includes polyacrylic acid, polyacrylamide, and polyvinyl alcohol, and the mass percentages of the polyacrylic acid, the polyacrylamide, and the polyvinyl alcohol are 1: 2: 1, the hydrophilic polymer has better biocompatibility, and the hydrophilicity of the hydrophilic coating is effectively improved.
Furthermore, the photoinitiator in S1 is an energy transfer initiator, the energy transfer initiator includes but is not limited to one or more of a benzophenone initiator and a benzophenone initiator, and absorbs light energy after receiving ultraviolet light irradiation to form active free radicals, so as to initiate chain polymerization of the prepolymer and the active diluent, so that the polyurethane adhesive is crosslinked and cured to form a network structure, and the initiator in 3-5 parts does not cause problems of too low polymerization speed, insufficient polymerization, influence on the curing speed and bonding strength of the adhesive, and waste caused by too much use amount, or even quenching caused by too much free radicals.
Further, the coupling agent in S2 includes but is not limited to one or more of a silane coupling agent and a titanate coupling agent, preferably a silane coupling agent, and the outer surface of the vascular sheath is coated with a coupling agent layer effective to perform molecular recombination treatment on the outer layer material of the vascular sheath to make the surface of the vascular sheath have the property of fusing with the hydrophilic coating.
Further, coating equipment and drying equipment set up side by side along the horizontal direction, and coating equipment and drying equipment bottom fixed mounting have an operation panel, one side that drying equipment kept away from coating equipment sets up drive mechanism, drive mechanism is arranged in carrying out traction movement to the vascular sheath in the coating, and drive mechanism drives the vascular sheath and carries out the level, realizes that the vascular sheath runs through the motion in coating equipment and drying equipment, accomplishes the drying process behind coating and the coating.
Furthermore, the coating equipment comprises a pair of vertical plates fixedly connected to an operating platform, a plurality of soaking cylinders are distributed between the two vertical plates at equal intervals, a lower supporting mechanism for supporting the soaking cylinders is fixedly installed on the operating platform, a group of upper limiting mechanism for limiting the top ends of the soaking cylinders is arranged between the two vertical plates and close to the upper ends of the two vertical plates, a through cavity is arranged in the soaking cylinders, a capillary fiber layer is wrapped inside one end of the through cavity, which is far away from the drying equipment, the top end of each soaking cylinder is fixedly connected with an inlet pipe communicated with the capillary fiber layer, the inlet pipes are connected to a communicating pipe, the capillary fiber layers arranged in the soaking cylinders can be uniformly impregnated with coatings, and vascular sheaths pass through the capillary fiber layers after being pulled by a traction mechanism, the surface of which is coated with a hydrophilic coating.
Further, lower supporting mechanism includes the bottom plate of fixed connection on the operation panel, fixedly connected with a plurality of and soak a feed cylinder assorted lower arc cover on the bottom plate, go up the position mechanism including being located the roof between two risers, the bottom fixedly connected with of roof a plurality of and lower arc cover assorted last arc cover, it locates to soak the pipe up end to go up the arc ways.
Further, drying equipment includes the drying cabinet of fixed mounting on the operation panel, the drying chamber that corresponds with a plurality of material pipe positions of soaking is seted up to the inside of drying cabinet, the ultraviolet ray light is installed on the top of drying chamber, the interior bottom end of drying chamber is opened and is dug have a plurality ofly and run through the through groove of chamber assorted, run through the chamber and run through the motion that the groove is used for the vascular sheath and run through, ultraviolet irradiation etc. easily carry out drying process to the coating surface.
Furthermore, the traction mechanism comprises a group of electric slide rails which are embedded and installed on the operation table, a traction plate is installed on one group of electric slide rails, one end, far away from the drying equipment, of the traction plate is rotatably provided with a plurality of transmission gears corresponding to the positions of the material soaking pipes, the plurality of transmission gears are connected through transmission chains, the inner ends of the plurality of transmission gears are fixedly connected with fixing rods which are fixed through vascular sheaths through connecting shafts, the side wall of the outer end of the traction plate is fixedly provided with a rotating motor which drives one of the transmission gears, when the traction mechanism works, the fixing rods are connected with the vascular sheaths to be coated, the vascular sheaths sequentially pass through the through cavity and the through groove, when the vascular sheaths pass through the through cavity, coating and ultraviolet illumination drying are carried out, and the plurality of fixing rods of the vascular sheaths can synchronously rotate under the effect of the transmission gears which are mutually transmitted, therefore, the vascular sheath can also perform relative rotary motion in the motion process, and the blood vessel sheath which rotationally advances is beneficial to improving the operation uniformity of the vascular sheath regardless of coating or illumination drying treatment, so that the coating quality is effectively improved.
Further, the top fixed seal of vascular sheath is connected with the sealing rod, the connecting rod that the sealing rod is connected with the dead lever through stock fixed connection, connecting rod threaded connection sets up one section sealing rod, stock and connecting rod's connection structure in the top of vascular sheath in the dead lever, and the vascular sheath is not direct to be connected with the dead lever, so can not cause the top of vascular sheath not to coat hydrophilic coating when the coating coats.
3. Advantageous effects
Compared with the prior art, the invention has the advantages that:
(1) the coating process of the scheme adopts N-vinyl pyrrolidone as a hydrophilic lubricating group, and adds a hydrophilic polymer, a polyurethane adhesive, a water-based cross-linking agent and an active diluent to effectively realize polymer chain polymerization so as to enable cross-linking and curing to form a net-shaped structure, the coating has adhesive force with certain strength, simultaneously, before coating, the surface treatment is carried out on the vascular sheath through a coupling agent, after the molecular recombination treatment is carried out on the outer layer material of the vascular sheath, the surface of the outer layer material of the vascular sheath has the characteristic of being fused with the hydrophilic coating under the condition of not influencing the structural strength of the vascular sheath, finally, the hydrophilic coating is coated on the outer surface of the vascular sheath by using special equipment, and the hydrophilic coating is uniformly coated on the vascular sheath in the rotating motion process of the vascular sheath, so that the smoothness of the outer surface coating of the vascular sheath is further effectively improved, and the coating is not easy to appear bumps or other uneven signs, the puncture needle has the advantages that large friction force cannot be generated during clinical puncture, and the pain of a patient is greatly relieved.
(2) A plurality of charging barrels of soaking level evenly distributed can carry out the coating to a plurality of vascular sheaths simultaneously, effectively improves machining efficiency, and a plurality of charging barrels of soaking can be dismantled from coating equipment, the subsequent clean operation of being convenient for.
(3) The vascular sheath passes in proper order and runs through the chamber and run through the groove, pass and carry out the coating cladding when running through the chamber, when passing and run through the groove, then carry out ultraviolet ray illumination drying, and can rotate in step under the effect of the drive gear of mutual transmission with a plurality of dead levers of vascular sheath, thereby the vascular sheath can also carry out relative rotary motion at the in-process of motion, the vascular sheath of rotatory advancing is no matter coating or illumination drying process all be favorable to improving its homogeneity of being operated, effectively improve coating quality.
Drawings
FIG. 1 is a flow chart of the present invention;
FIG. 2 is a perspective view of the coating apparatus, drying apparatus and pulling apparatus combination of the present invention;
FIG. 3 is a cross-sectional view of the interior at the dip tube;
FIG. 4 is a perspective view of the combination of the spray coating device and the drying device of the present invention;
FIG. 5 is a partial perspective view of the spray apparatus of the present invention;
FIG. 6 is a perspective view of the upper stop mechanism of the present invention;
FIG. 7 is a perspective view of the present invention at a pulling mechanism;
FIG. 8 is a perspective view of the present invention at the junction of a traction plate and a fixation rod;
fig. 9 is a perspective view of the junction of a vascular sheath and a long shaft of the present invention.
The reference numbers in the figures illustrate:
1 ultrasonic reaction kettle, 2 coating equipment, 3 drying equipment, 4 material soaking cylinders, 401 through cavities, 402 capillary fiber layers, 5 bottom plates, 6 lower arc sleeves, 7 feeding pipes, 8 communicating pipes, 9 top plates, 10 upper arc sleeves, 11 drying cavities, 12 through grooves, 13 traction plates, 14 electric slide rails, 15 transmission gears, 16 transmission chains, 17 rotating motors, 18 fixing rods, 19 connecting rods, 20 sealing rods and 21 long rods.
Detailed Description
The drawings in the embodiments of the invention will be combined; the technical scheme in the embodiment of the invention is clearly and completely described; obviously; the described embodiments are only some of the embodiments of the invention; but not all embodiments, are based on the embodiments of the invention; all other embodiments obtained by a person skilled in the art without making any inventive step; all fall within the scope of protection of the present invention.
In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "top/bottom", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "disposed," "sleeved/connected," "connected," and the like are to be construed broadly, e.g., "connected," which may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Example 1:
referring to fig. 1-2, the process of applying a hydrophilic coating on the surface of the vascular sheath specifically includes the following steps:
s1, preparation of hydrophilic coating raw materials: 55-80 parts of N-vinyl pyrrolidone serving as a hydrophilic lubricating component is placed in an ultrasonic reaction kettle 1, 10-15 parts of hydrophilic polymer, 3-6 parts of polyurethane adhesive, 3-5 parts of photoinitiator, 1-2 parts of active diluent, 0.5-1.5 parts of physical resistance reducing agent, 2-3 parts of water-based cross-linking agent, 0.5-1 part of antibacterial agent and 0.6-0.9 part of flatting agent are added in the ultrasonic reaction kettle 1, and the raw materials are mixed and stirred to prepare a hydrophilic coating raw material;
s2, surface treatment of vascular sheath: placing the vascular sheath in an ethanol solution for ultrasonic washing to remove dust and stains on the vascular sheath, washing the vascular sheath by pure water after ultrasonic washing to remove the ethanol solution on the vascular sheath, placing the washed vascular sheath in pure water at 30-37 ℃ for soaking for 2-4d, taking out and carrying out irradiation drying by using an ultraviolet lamp at 25-35 ℃ after soaking is finished, finally soaking the dried vascular sheath in a coupling agent, taking out after uniform soaking and carrying out irradiation drying again by using the ultraviolet lamp at 25-35 ℃ for later use;
s3, carrying out surface hydrophilic coating on the vascular sheath: connecting an ultrasonic reaction kettle 1 with a coating device 2 through a communicating pipe 8, fixedly installing a pump body on the communicating pipe 8, conveying a hydrophilic coating raw material into the coating device 2 through the communicating pipe 8 by the ultrasonic reaction kettle 1, enabling a vascular sheath to rotate and penetrate through the hydrophilic coating raw material in the coating device 2, and uniformly coating the hydrophilic coating raw material on the outer surface of the vascular sheath;
s4, drying the coating: the vascular sheath coated with the hydrophilic coating raw material moves into the drying equipment 3 arranged on one side of the coating equipment 2, so that the coating is dried, and the operation of adding the hydrophilic coating on the surface of the vascular sheath is completed after the drying is completed.
It should be emphasized here that the hydrophilic polymer in S1 includes polyacrylic acid, polyacrylamide, and polyvinyl alcohol, and the mass percentage of polyacrylic acid, polyacrylamide, and polyvinyl alcohol is 1: 2: 1, the hydrophilic polymer has better biocompatibility, the hydrophilicity of the hydrophilic coating is effectively improved, the photoinitiator in S1 is an energy transfer type initiator, the energy transfer type initiator comprises but is not limited to one or more of a benzophenone initiator and a benzophenone initiator, after the photoinitiator receives ultraviolet irradiation, the energy of light absorption is carried out to form active free radicals, chain polymerization of the prepolymer and the active diluent is initiated, the polyurethane adhesive is crosslinked and cured to form a net-shaped structure, a person skilled in the art can install an ultraviolet lamp at a proper position in the ultrasonic reaction kettle 1, the ultraviolet lamp is not shown in the figure, the description is omitted, 3-5 parts of the initiator is selected, the problems of too low polymerization speed, insufficient polymerization, influence on the curing speed and bonding strength of the adhesive and the like caused by too much dosage are avoided, and waste caused by too much dosage is avoided, It is even possible that too many radicals lead to quenching.
The coupling agent in S2 includes but is not limited to one or more of silane coupling agent and titanate coupling agent, preferably silane coupling agent, the outer surface of the vascular sheath is coated with a coupling agent layer, which is effective in molecular recombination treatment of the outer material of the vascular sheath to make the surface of the outer material have the characteristic of fusing with the hydrophilic coating.
Referring to fig. 2, the coating device 2 and the drying device 3 are arranged in parallel along the horizontal direction, an operation table is fixedly installed at the bottom ends of the coating device 2 and the drying device 3, a traction mechanism is arranged on one side, far away from the coating device 2, of the drying device 3, the traction mechanism is used for performing traction movement on the coated vascular sheath, the traction mechanism drives the vascular sheath to be horizontal, the vascular sheath is enabled to move in the coating device 2 and the drying device 3 in a penetrating mode, and drying treatment of the coating and the coating is completed.
Specifically, the coating equipment 2 comprises a pair of vertical plates fixedly connected to an operating platform, a plurality of soaking cylinders 4 are distributed between the two vertical plates at equal intervals, a lower supporting mechanism for supporting the soaking cylinders 4 is fixedly installed on the operating platform, a group of upper limiting mechanisms for limiting the top ends of the soaking cylinders 4 are arranged between the two vertical plates and close to the upper ends of the two vertical plates, a through cavity 401 is arranged in the soaking cylinders 4, a capillary fiber layer 402 is wrapped inside one end of the through cavity 401 far away from the drying equipment 3, a feed pipe 7 communicated with the capillary fiber layer 402 is fixedly connected to the top end of each soaking cylinder 4, the feed pipes 7 are connected to a communicating pipe 8, the plurality of soaking cylinders 4 are supported through the cooperation of the upper limiting mechanisms and the lower supporting mechanism, hydrophilic coatings are introduced into the through cavity 401 through the feed pipes 7, and the capillary fiber layers 402 arranged in the soaking cylinders 4 can be uniformly impregnated with coatings, the blood vessel sheath passes through the capillary fiber layer 402 after being pulled by the pulling mechanism, a plurality of capillary vessels are distributed in the capillary fiber layer 402, so that the surface of the blood vessel sheath is uniformly coated with a hydrophilic coating, the coating is easily and uniformly conducted to the outer surface of the blood vessel sheath, in addition, the capillary fiber layer 402 is arranged at the initial end position of the soaking cylinder 4, the capillary fiber layer 402 soaked with the coating conducts the coating to the blood vessel sheath, the relatively redundant coating of the blood vessel sheath in the continuous motion process can be thrown to the tail end of the through cavity 401 in the motion process, and therefore the redundant coating is effectively prevented from being splashed to the operating table.
Wherein, the bottom plate 5 of lower supporting mechanism on fixed connection on the operation panel, fixedly connected with is a plurality of and soaks a material section of thick bamboo 4 assorted lower arc cover 6 on the bottom plate 5, go up the position mechanism including being located the roof 9 between two risers, the bottom fixedly connected with of roof 9 a plurality of and lower arc cover 6 assorted go up arc cover 10, go up arc cover 10 cover and locate soaking pipe 4 up end, roof 9 passes through on bolt fastening and the riser, be convenient for follow-up dismouting operation, so that dismantle cleanly to a plurality of soaking pipes 4.
The traction mechanism comprises a group of electric slide rails 14 which are embedded and installed on the operation table, a traction plate 13 is installed on the group of electric slide rails 14, one end, far away from the drying equipment 3, of the traction plate 13 is rotatably provided with a plurality of transmission gears 15 corresponding to the positions of the material soaking pipes 4, the plurality of transmission gears 15 are in transmission connection through a transmission chain 16, the inner ends of the plurality of transmission gears 15 are fixedly connected with fixing rods 18 which are fixed through vascular sheaths through connecting shafts, the side wall of the outer end of the traction plate 13 is fixedly provided with a rotating motor 17 which drives one of the transmission gears 15, when the traction mechanism works, the fixing rods 18 are connected with the vascular sheaths to be coated, the vascular sheaths sequentially pass through the through cavity 401 and the through groove 12 and are coated, when the vascular sheaths pass through the through cavity 401, ultraviolet irradiation drying is carried out, and the plurality of fixing rods 18 with the vascular sheaths can synchronously rotate under the action of the transmission gears 15 which are mutually transmitted, therefore, the vascular sheath can also perform relative rotary motion in the motion process, and the blood vessel sheath which rotationally advances is beneficial to improving the operation uniformity of the vascular sheath regardless of coating or illumination drying treatment, so that the coating quality is effectively improved.
In addition, please refer to fig. 9, the starting end of the vascular sheath is fixedly and sealingly connected with a sealing rod 20, the sealing rod 20 is fixedly connected with a connecting rod 19 connected with the fixing rod 18 through a long rod 21, the connecting rod 19 is in threaded connection with the fixing rod 18, the starting end of the vascular sheath is provided with a section of the sealing rod 20, the long rod 21 and the connecting structure of the connecting rod 19, the vascular sheath is not directly connected with the fixing rod 18, so that the starting end of the vascular sheath is not coated with a hydrophilic coating when the coating is coated, and the vascular sheath is sealed through the sealing rod 20, thereby effectively preventing the coating from being introduced into the vascular sheath, and the tail end of the vascular sheath can also be sealed through the sealing rod 20.
The above; but are merely preferred embodiments of the invention; the scope of the invention is not limited thereto; any person skilled in the art is within the technical scope of the present disclosure; the technical scheme and the improved concept of the invention are equally replaced or changed; are intended to be covered by the scope of the present invention.
Claims (8)
1. The process for adding the hydrophilic coating on the surface of the vascular sheath is characterized in that: the method specifically comprises the following steps:
s1, preparation of hydrophilic coating raw materials: 55-80 parts of N-vinyl pyrrolidone serving as a hydrophilic lubricating component is placed in an ultrasonic reaction kettle (1), 10-15 parts of hydrophilic polymer, 3-6 parts of polyurethane adhesive, 3-5 parts of photoinitiator, 1-2 parts of active diluent, 0.5-1.5 parts of physical resistance reducing agent, 2-3 parts of water-based cross-linking agent, 0.5-1 part of antibacterial agent and 0.6-0.9 part of flatting agent are added in the ultrasonic reaction kettle (1), and the raw materials are mixed and stirred to prepare a hydrophilic coating raw material;
s2, surface treatment of vascular sheath: placing the vascular sheath in an ethanol solution for ultrasonic washing to remove dust and stains on the vascular sheath, washing the vascular sheath by pure water after ultrasonic washing to remove the ethanol solution on the vascular sheath, placing the washed vascular sheath in pure water at 30-37 ℃ for soaking for 2-4d, taking out and carrying out irradiation drying by using an ultraviolet lamp at 25-35 ℃ after soaking is finished, finally soaking the dried vascular sheath in a coupling agent, taking out after uniform soaking and carrying out irradiation drying again by using the ultraviolet lamp at 25-35 ℃ for later use;
s3, carrying out surface hydrophilic coating on the vascular sheath: the method comprises the following steps that an ultrasonic reaction kettle (1) is connected with coating equipment (2) through a communicating pipe (8), a pump body is fixedly installed on the communicating pipe (8), the ultrasonic reaction kettle (1) conveys hydrophilic coating raw materials into the coating equipment (2) through the communicating pipe (8), a vascular sheath rotates to move to penetrate through the hydrophilic coating raw materials in the coating equipment (2), and the hydrophilic coating raw materials are uniformly coated on the outer surface of the vascular sheath;
s4, drying the coating: the vascular sheath coated with the hydrophilic coating raw material moves into a drying device (3) arranged on one side of the coating device (2) to realize the drying treatment of the coating, and the hydrophilic coating operation on the surface of the vascular sheath is completed after the drying is completed; the coating device (2) and the drying device (3) are arranged in parallel along the horizontal direction, operation tables are fixedly installed at the bottom ends of the coating device (2) and the drying device (3), a traction mechanism is arranged on one side, far away from the coating device (2), of the drying device (3), and the traction mechanism is used for performing traction movement on a coated vascular sheath; coating equipment (2) include a pair of riser of fixed connection on the operation panel, two equidistant distribution has a plurality of feed cylinder (4) of soaking between the riser, fixed mounting has the lower supporting mechanism who supports to soaking feed cylinder (4) on the operation panel, two the riser is close to and is provided with a set of upper limit mechanism that carries on spacingly to soaking feed cylinder (4) top between the upper end, it runs through chamber (401) to be equipped with in the feed cylinder (4) to soak, the inside cladding of one end that runs through chamber (401) and keep away from drying equipment (3) has capillary fiber layer (402), every soak feed pipe (7) that the top fixedly connected with of feed cylinder (4) is linked together with capillary fiber layer (402), it is a plurality of feed pipe (7) are connected on communicating pipe (8).
2. The process of claim 1, wherein the surface of the vascular sheath is coated with a hydrophilic coating, and the process comprises the following steps: the hydrophilic polymer in the S1 comprises polyacrylic acid, polyacrylamide and polyvinyl alcohol, and the mass percentages of the polyacrylic acid, the polyacrylamide and the polyvinyl alcohol are 1: 2: 1.
3. the process of claim 1, wherein the surface of the vascular sheath is coated with a hydrophilic coating, and the process comprises the following steps: the photoinitiator in S1 is an energy transfer type initiator, and the energy transfer type initiator is a benzophenone initiator.
4. The process of claim 1, wherein the surface of the vascular sheath is coated with a hydrophilic coating, and the process comprises the following steps: the coupling agent in S2 is selected from one or more of silane coupling agent and titanate coupling agent.
5. The process of claim 1, wherein the surface of the vascular sheath is coated with a hydrophilic coating, and the process comprises the following steps: the lower supporting mechanism comprises a bottom plate (5) fixedly connected to the operating platform, the bottom plate (5) is fixedly connected with a plurality of lower arc sleeves (6) matched with the soaking cylinders (4), the upper limiting mechanism comprises a top plate (9) located between two vertical plates, the bottom end of the top plate (9) is fixedly connected with a plurality of upper arc sleeves (10) matched with the lower arc sleeves (6), and the upper end faces of the soaking cylinders (4) are sleeved with the upper arc sleeves (10).
6. The process of claim 5 for hydrophilic coating on the surface of vascular sheath, wherein: drying equipment (3) are including fixed mounting's drying cabinet on the operation panel, drying chamber (11) that correspond with a plurality of soaking cylinder (4) positions are seted up to the inside of drying cabinet, the ultraviolet ray light is installed on the top of drying chamber (11), the interior bottom end of drying chamber (11) is opened and is dug a plurality ofly and run through chamber (401) assorted and run through groove (12), run through chamber (401) and run through groove (12) and be used for the motion of vascular sheath to run through.
7. The process of claim 6, wherein the surface of the vascular sheath is coated with a hydrophilic coating, and the process comprises the following steps: traction mechanism is including inlaying a set of electronic slide rail (14) of establishing and installing on the operation panel, and is a set of install traction plate (13) on electronic slide rail (14), the one end that drying equipment (3) were kept away from in traction plate (13) rotates and installs a plurality ofly and soaks drive gear (15) that feed cylinder (4) position corresponds, and is a plurality of drive gear (15) are connected through drive chain (16) transmission, and are a plurality of the inner of drive gear (15) is used for vascular sheath to carry out dead lever (18) fixed through connecting axle fixedly connected with, fixed mounting has on the outer end lateral wall of traction plate (13) and carries out driven rotating electrical machines (17) to one of them drive gear (15).
8. The process of claim 7, wherein the surface of the vascular sheath is coated with a hydrophilic coating, and the process comprises the following steps: the starting end of the vascular sheath is fixedly and hermetically connected with a sealing rod (20), the sealing rod (20) is fixedly connected with a connecting rod (19) connected with the fixing rod (18) through a long rod (21), and the connecting rod (19) is in threaded connection with the inside of the fixing rod (18).
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