CN111076843A - Method and device for measuring human body circadian rhythm - Google Patents

Method and device for measuring human body circadian rhythm Download PDF

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Publication number
CN111076843A
CN111076843A CN201911417892.4A CN201911417892A CN111076843A CN 111076843 A CN111076843 A CN 111076843A CN 201911417892 A CN201911417892 A CN 201911417892A CN 111076843 A CN111076843 A CN 111076843A
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infrared radiation
time
data
radiation temperature
day
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牟希
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Zhejiang Smart Lighting Technology Co ltd
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Zhejiang Smart Lighting Technology Co ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01KMEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K13/00Thermometers specially adapted for specific purposes
    • G01K13/20Clinical contact thermometers for use with humans or animals
    • G01K13/223Infrared clinical thermometers, e.g. tympanic
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J5/00Radiation pyrometry, e.g. infrared or optical thermometry
    • G01J5/0003Radiation pyrometry, e.g. infrared or optical thermometry for sensing the radiant heat transfer of samples, e.g. emittance meter
    • G01J5/0011Ear thermometers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J5/00Radiation pyrometry, e.g. infrared or optical thermometry
    • G01J5/02Constructional details
    • G01J5/0225Shape of the cavity itself or of elements contained in or suspended over the cavity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J5/00Radiation pyrometry, e.g. infrared or optical thermometry
    • G01J5/02Constructional details
    • G01J5/03Arrangements for indicating or recording specially adapted for radiation pyrometers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J5/00Radiation pyrometry, e.g. infrared or optical thermometry
    • G01J5/02Constructional details
    • G01J5/04Casings
    • GPHYSICS
    • G08SIGNALLING
    • G08CTRANSMISSION SYSTEMS FOR MEASURED VALUES, CONTROL OR SIMILAR SIGNALS
    • G08C17/00Arrangements for transmitting signals characterised by the use of a wireless electrical link
    • G08C17/02Arrangements for transmitting signals characterised by the use of a wireless electrical link using a radio link

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

The embodiment of the invention provides a method and a device for measuring the circadian rhythm of a human body, wherein the method comprises the following steps that a measuring circuit sends out a sampling electric signal at every other given time; the infrared radiation temperature detector collects the infrared radiation temperature of the eardrum and the deep part of the peripheral ear cavity at the moment under the control of the sampling electric signal; the collected infrared radiation temperature and the time corresponding to the sampling moment are simultaneously stored in a memory according to the front and back time sequence; a group of data such as infrared radiation temperature and corresponding sampling time collected in a period of time in the memory are received by an intelligent terminal through wireless transmission, and are arranged and stored in the intelligent terminal according to the time sequence of the sampling time; the intelligent terminal performs combined calculation on infrared radiation temperature data during at least one day (day and night), and obtains human body circadian rhythm according to temperature variation data of the day and the night.

Description

Method and device for measuring human body circadian rhythm
Technical Field
The invention relates to the technical field of medical measurement, in particular to a method and a device for measuring human body circadian rhythm.
Background
According to research, the absorption of the drug effect is more dependent on the physiological time of the patient than the global time, such as: the inpatient is in the ward light for a long time, because the patient can not get up or go out inconveniently, so the patient can not contact the external sunlight, the physiological probability of the patient is different from the rhythm time of 24 hours on earth, according to scientific research and known knowledge, the patient's own circadian rhythm can be known to have important influence on the drug effect, the traditional method for examining the patient's circadian rhythm in hospital is through the test of urine and melatonin, and has some problems:
1. for example, the acquisition process is not only cumbersome but also takes a long time for one acquisition, and brings a bad experience to the patient.
2. The acquisition means is very professional and can be realized only by a hospital, and the patient cannot measure at home.
In order to solve the acquisition problem of the medical measurement industry, a series of body temperature detection devices appear in the market in recent years, the main structure is a hand-held infrared in-ear detection mode, but the problems of low measurement precision, heaviness, inconvenience in use and the like still exist in an equipment measurement method.
Disclosure of Invention
In view of this, embodiments of the present invention provide a circadian rhythm measuring method and apparatus, which solve the problem of inconvenience in acquiring circadian rhythms.
The technical scheme adopted by the embodiment of the invention is as follows: a circadian rhythm measurement method, the method comprising:
the measuring circuit sends out a sampling electric signal every other given time;
the infrared radiation temperature detector collects the infrared radiation temperature of the eardrum and the deep part of the peripheral ear cavity at the moment under the control of the sampling electric signal;
the collected infrared radiation temperature and the time corresponding to the sampling moment are simultaneously stored in a memory according to the front and back time sequence;
a group of data such as infrared radiation temperature and corresponding sampling time collected in a period of time in the memory are received by an intelligent terminal through wireless transmission, and are arranged and stored in the intelligent terminal according to the time sequence of the sampling time;
the intelligent terminal performs combined calculation on infrared radiation temperature data during at least one day (day and night), and obtains human body circadian rhythm according to temperature variation data of the day and the night.
By adopting the technical scheme, the embodiment of the invention has the following beneficial effects: the traditional method for acquiring the circadian rhythm is that a user can go to a hospital to finish the acquisition by urine and melatonin, and the traditional method is very troublesome, expensive and has poor experience. According to the embodiment of the invention, the infrared radiation temperature of the eardrum and the deep part of the peripheral ear cavity at the moment is rapidly acquired in a non-contact way through infrared radiation, and is wirelessly transmitted to an intelligent terminal for data combination calculation to obtain the circadian rhythm parameters of the human body; the method is convenient, reliable, accurate and low in cost, and solves the existing problems.
In order to more accurately obtain the human body circadian rhythm parameters, the infrared radiation temperature data are combined and calculated by adopting the following method:
extracting infrared radiation temperature data of deep parts of the eardrum and peripheral ear cavities for at least five days (day and night) before a given time; if the data at some time is lacked in the required time, the data at the time are eliminated in the combined calculation;
carrying out weighted average calculation on the infrared radiation temperature data at the same moment every day in required time; the weighting coefficients are decreased with the previous days, and the weighting coefficients at different moments in the same day (day and night) are equal;
and performing curve smooth fitting on the infrared radiation temperature data of one day (day and night) obtained by weighted average calculation to obtain day and night temperature variation data of the human body.
In order to express the human circadian rhythm more reasonably, the temperature variation data are subjected to least square fitting according to a sine curve; the time corresponding to the lowest valley bottom of the fitted sine curve is the starting time of the human circadian rhythm period. The time may correspond to public social time with a time difference of 3 to 4 hours; for example, the start of a human circadian cycle is considered to be the public social time 3 am, and so on for other times.
An embodiment of the present invention further provides a device for measuring circadian rhythm of a human body, including: the device comprises an infrared radiation temperature detector, a measuring circuit, a memory, an ear cavity adapting shell, a wireless transmission circuit, an intelligent terminal and a built-in power supply.
The infrared radiation temperature detector, the measuring circuit, the memory, the wireless transmission circuit and the built-in power supply are arranged in the ear cavity adapting shell; the infrared radiation temperature detector is arranged at the front end facing to the direction of the eardrum, the central normal line of the infrared radiation temperature detector points to the middle position of the eardrum at the deep part of the eardrum, and the infrared radiation temperature detector receives the infrared radiation from the eardrum and the deep part of the peripheral eardrum and converts the infrared radiation into an electric signal.
The measuring circuit is arranged in the ear cavity adapting shell and is connected with the infrared radiation temperature detector through electric signals, the electric signals output by the infrared radiation temperature detector are collected at regular intervals, and the electric signals are sent to the intelligent terminal through the wireless transmission circuit.
The memory is positioned in the ear cavity adapting shell and is close to the measuring circuit; and simultaneously storing the collected infrared radiation temperature and the time corresponding to the sampling moment according to the front and back time sequences.
The ear cavity adapting shell is a cavity shell, and an infrared radiation temperature detector, a measuring circuit, a memory and a wireless transmission circuit are arranged in the cavity; the outer side of the front end matches the ear cavity.
The intelligent terminal has a wireless data receiving function, and receives data which is transmitted by an electric signal detector, collects electric signals output by the infrared radiation temperature detector at intervals within a certain time and transmits the electric signals through a wireless transmission circuit; is structurally separated from the main measuring part.
The technical scheme has the advantages that 1) the detection of continuous measurement and record of the day and night temperature of the human body is realized; 2) the ear cavity can be worn in the ear cavity, the non-contact measurement is realized, and the resolution ratio is high and accurate; 3) convenient measurement, small volume, power saving and the like.
The storage space of the human body core temperature detector is limited, so that the storage space in the detector always keeps the latest data and directly corresponds to the time. According to the above-mentioned human body circadian rhythm measuring device, its said data memory keeps collecting time and signal data at the same time according to the time sequence, the time data include month, day, hour, minute; the stored acquisition time and signal data are stored circularly, that is, after the stored data of the memory reach the maximum data storage amount, the newly acquired acquisition time and signal data are stored in the earliest stored storage space unit to replace the original stored data; and then stored one by one.
Considering a human core temperature detector worn in the ear cavity, portability, low power consumption, long continuous operation time are extremely important properties. A human circadian rhythm measuring device according to the above, characterized in that said measuring circuit comprises an electric signal microprocessor, a time base circuit; after the electric signal microprocessor finishes collecting the electric signal of the infrared radiation temperature detector at a certain moment, the measuring circuit and the wireless transmission circuit are in a dormant or electric off state; the time base circuit can output signals in a timing mode, and the measuring circuit and the wireless transmission circuit are activated or started; the timing output signal period of the time-base circuit is greater than the sum of the time required by the electric signal microprocessor to collect the electric signal of the infrared radiation temperature detector and the time required for the measuring circuit and the wireless transmission circuit to enter a dormant state or an electric off state.
In order to measure the human body core temperature more accurately, the human body circadian rhythm measuring device is characterized in that the ear cavity adapting shell also comprises an infrared radiation receiving head; the infrared radiation receiving head is in heat conduction connection with a shell of the infrared radiation temperature detector, the infrared radiation receiving head is provided with an infrared light converging lens, and the effective receiving angle (50% half-peak sensitivity) of a light beam formed by combining the infrared light converging lens and the infrared radiation temperature detector is not more than 30 degrees.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention and not to limit the invention. In the drawings:
FIG. 1 is a schematic diagram of a human circadian rhythm measuring device according to an embodiment of the invention;
fig. 2 is a schematic structural diagram of an ear cavity adapting housing according to an embodiment of the present invention.
Detailed Description
Reference will now be made in detail to the exemplary embodiments, examples of which are illustrated in the accompanying drawings. In the following description and in the drawings, the same numbers in different drawings identify the same or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present application. Rather, they are merely examples of apparatus consistent with certain aspects of the present application, as detailed in the appended claims. Various embodiments of the present description are described in an incremental manner.
As shown in fig. 1 and 2, a human circadian rhythm measuring apparatus employed in an embodiment of the present invention includes: the device comprises an infrared radiation temperature detector 1, a measuring circuit 2, a memory 3, an ear cavity adapting shell 4, a wireless transmission circuit 5, an intelligent terminal 6 and a built-in power supply 7.
The infrared radiation temperature detector 1, the measuring circuit 2, the memory 3, the wireless transmission circuit 5 and the built-in power supply 7 are arranged in the ear cavity adapting shell 4; the infrared radiation temperature detector 1 is located at the front end facing the eardrum direction, and the center normal thereof points to the middle position of the eardrum at the deep part of the eardrum, receives infrared radiation from the eardrum and the deep part of the peripheral eardrum, and converts the infrared radiation into an electric signal.
The measuring circuit 2 is arranged in the ear cavity adaptive shell 4, is connected with the infrared radiation temperature detector 1 through electric signals, collects the electric signals output by the infrared radiation temperature detector 1 at regular intervals, and sends the electric signals to the intelligent terminal 6 through the wireless transmission circuit 5.
The memory 3 is positioned in the ear cavity adapting shell 4 and close to the measuring circuit 2; and simultaneously storing the collected infrared radiation temperature and the time corresponding to the sampling moment according to the front and back time sequences.
The ear cavity adapting shell 4 is a cavity shell, and an infrared radiation temperature detector 1, a measuring circuit 2, a memory 3, a wireless transmission circuit 5 and the like are arranged in the cavity; the outer side of the front end matches the ear cavity.
The intelligent terminal 6 has a wireless data receiving function, and receives data which is transmitted by the wireless transmission circuit 5 and is obtained by the electric signal detector 2 at certain time intervals to collect electric signals output by the infrared radiation temperature detector 1; is structurally separated from the main measuring part.
The technical scheme has the advantages that 1, the detection of continuous measurement and recording of day and night temperature of a human body is realized; 2 can be worn in the ear cavity, and has non-contact measurement, high resolution and accuracy; 3 convenient measurement, small volume, power saving, etc.
In one embodiment of the invention, to solve the storage space limitation of the human body temperature detector, the storage space in the detector always keeps the latest data and directly corresponds to the time. According to the above-mentioned a human body circadian rhythm measuring device, its said data memory 3 keeps collecting time and signal data at the same time according to the time sequence, the time data include month, day, hour, minute; the stored acquisition time and signal data are stored circularly, that is, when the storage data of the memory 3 reaches the maximum data storage amount, the newly acquired acquisition time and signal data are stored in the earliest storage space unit to replace the original storage data; and then stored one by one.
In one embodiment of the invention, lightweight, low power consumption, long continuous operation time are extremely important properties in view of a human body core temperature detector worn in the ear cavity. A human circadian rhythm measuring apparatus according to the above, characterized in that said measuring circuit 2 comprises an electric signal microprocessor 21, a time base circuit 22; after the electric signal microprocessor 21 finishes collecting the electric signal of the infrared radiation temperature detector 1 at a certain moment, the measuring circuit 2 and the wireless transmission circuit 5 are in a dormant or electric off state; the time base circuit 22 can output signals in a timing mode to activate or start the measuring circuit 2 and the wireless transmission circuit 5; the time base circuit 22 has a timed output signal period greater than the sum of the time required for the electrical signal microprocessor 21 to collect the electrical signal of the infrared radiation temperature detector 1 and the time required for the measurement circuit 2 and the wireless transmission circuit 5 to enter the sleep or electrically off state.
The specific device detects the wearing state in the ear cavity, and the device measuring circuit detects and collects the temperature of eardrum radiation at the time interval of starting the device and stores the temperature in the storage in sequence; measuring the sleep mode; the measurement is carried out once every 5 minutes, the measurement time is 10s, and the rest 4 minutes and 50s are in a power saving mode.
In an embodiment of the present invention, in order to measure the human body core temperature more accurately, according to the above-mentioned human body circadian rhythm measuring device, the ear cavity fitting housing 4 further comprises an infrared radiation receiving head 45; the infrared radiation receiving head 45 is connected with a shell of the infrared radiation temperature detector 1 in a heat conduction mode, an infrared light converging lens is installed on the infrared radiation receiving head 45, and an effective receiving angle (50% half-peak sensitivity) of a light beam formed by combining the infrared light converging lens and the infrared radiation temperature detector 1 is not more than 30 degrees.
The embodiment of the invention provides a method for measuring human body circadian rhythm, which comprises the following steps:
the measuring circuit sends out a sampling electric signal every other given time; the infrared radiation temperature detector collects the infrared radiation temperature of the eardrum and the deep part of the peripheral ear cavity at the moment under the control of the sampling electric signal; the collected infrared radiation temperature and the time corresponding to the sampling moment are simultaneously stored in a memory according to the front and back time sequence; a group of data such as infrared radiation temperature and corresponding sampling time collected in a period of time in the memory are received by an intelligent terminal through wireless transmission, and are arranged and stored in the intelligent terminal according to the time sequence of the sampling time; the intelligent terminal performs combined calculation on infrared radiation temperature data during at least one day (day and night), and obtains human body circadian rhythm according to temperature variation data of the day and the night.
In an embodiment of the invention, in order to more accurately obtain the human circadian rhythm parameters, the above-described infrared radiation temperature data are subjected to combined calculation by extracting infrared radiation temperature data deep in the eardrum and peripheral ear cavities for at least five days (circadian) before a given time; if the data at some time is lacked in the required time, the data at the time are eliminated in the combined calculation; carrying out weighted average calculation on the infrared radiation temperature data at the same moment every day in required time; the weighting coefficients are decreased with the previous days, and the weighting coefficients at different moments in the same day (day and night) are equal; and performing curve smooth fitting on the infrared radiation temperature data of one day (day and night) obtained by weighted average calculation to obtain day and night temperature variation data of the human body.
In one embodiment of the invention, in order to express the human circadian rhythm more reasonably, the temperature variation data are subjected to least square fitting according to a sine curve; the time corresponding to the lowest valley bottom of the fitted sine curve is the starting time of the human circadian rhythm period. The time may correspond to public social time with a time difference of 3 to 4 hours; for example, the start of a human circadian cycle is considered to be the public social time 3 am, and so on for other times.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by using the contents of the present specification and the accompanying drawings, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims (7)

1. A method for measuring a circadian rhythm of a human body, comprising:
the measuring circuit sends out a sampling electric signal every other given time;
the infrared radiation temperature detector collects the infrared radiation temperature of the eardrum and the deep part of the peripheral ear cavity at the moment under the control of the sampling electric signal;
the collected infrared radiation temperature and the time corresponding to the sampling moment are simultaneously stored in a memory according to the front and back time sequence;
the infrared radiation temperature collected in a period of time and the time of the corresponding sampling time in the memory are a group of data, the data are received by an intelligent terminal through wireless transmission, and the data are arranged and stored in the intelligent terminal according to the time sequence of the sampling time;
the intelligent terminal performs combined calculation on infrared radiation temperature data during at least one day (day and night), and obtains human body circadian rhythm according to temperature variation data of the day and the night.
2. The method of claim 1, wherein the data of the temperature of the infrared radiation is combined and calculated by the following method:
extracting infrared radiation temperature data of deep parts of the eardrum and peripheral ear cavities for at least five days (day and night) before a given time; if the data at some time is lacked in the required time, the data at the time are eliminated in the combined calculation;
carrying out weighted average calculation on the infrared radiation temperature data at the same moment every day in required time; the weighting coefficients are decreased with the previous days, and the weighting coefficients at different moments in the same day (day and night) are equal;
and performing curve smooth fitting on the infrared radiation temperature data of one day (day and night) obtained by weighted average calculation to obtain day and night temperature variation data of the human body.
3. A human circadian rhythm measurement method according to claim 1 or 2, wherein the human circadian rhythm is determined by:
carrying out least square fitting on day and night temperature variation data according to a sine curve;
the time corresponding to the lowest valley bottom of the fitted sine curve is the starting time of the human circadian rhythm period.
4. A human circadian rhythm measuring apparatus characterized by comprising:
the device comprises an infrared radiation temperature detector (1), a measuring circuit (2), a memory (3), an ear cavity adapting shell (4), a wireless transmission circuit (5), an intelligent terminal (6) and a built-in power supply (7);
the infrared radiation temperature detector (1), the measuring circuit (2), the memory (3), the wireless transmission circuit (5) and the built-in power supply (7) are arranged in the ear cavity adapting shell (4); the infrared radiation temperature detector (1) is arranged at the front end facing to the direction of the eardrum, the central normal line of the infrared radiation temperature detector points to the middle position of the eardrum at the deep part of the eardrum, and the infrared radiation temperature detector receives the infrared radiation from the eardrum and the deep part of the peripheral eardrum and converts the infrared radiation into an electric signal;
the measuring circuit (2) is arranged in the ear cavity adaptive shell (4), is connected with an electric signal of the infrared radiation temperature detector (1), collects the electric signal output by the infrared radiation temperature detector (1) at regular intervals, and sends the electric signal to the intelligent terminal (6) through the wireless transmission circuit (5);
the storage (3) is positioned in the ear cavity adapting shell (4) and is close to the measuring circuit (2); simultaneously storing the collected infrared radiation temperature and the time corresponding to the sampling moment according to the front and back time sequence;
the ear cavity adapting shell (4) is a cavity shell, and an infrared radiation temperature detector (1), a measuring circuit (2), a memory (3) and a wireless transmission circuit (5) are arranged in the cavity; the outer side surface of the front end part is matched with the ear cavity;
the intelligent terminal (6) has a wireless data receiving function, and receives data which is transmitted by the wireless transmission circuit (5) and is used for acquiring the electric signals output by the infrared radiation temperature detector (1) at intervals within a certain time by the electric signal detector (2); is structurally separated from the main measuring part.
5. The circadian rhythm measuring apparatus for human body according to claim 1 or 4, wherein said memory (3) simultaneously stores acquisition time and signal data in time series, the time data including month, day, hour, minute; the stored acquisition time and signal data are stored circularly, namely when the storage data of the memory (3) reach the maximum storable data quantity, the newly acquired acquisition time and signal data are stored in the earliest stored storage space unit to replace the original storage data; and then stored one by one.
6. A human circadian rhythm measuring device according to claim 4, characterized in that said measuring circuit (2) comprises an electric signal microprocessor (21), a time base circuit (22); after the electric signal microprocessor (21) finishes collecting the electric signal of the infrared radiation temperature detector (1) at a certain moment, the measuring circuit (2) and the wireless transmission circuit (5) enter a dormant or electric off state; the time base circuit (22) can output signals in a timing mode, and the measuring circuit (2) and the wireless transmission circuit (5) are activated or started; the timing output signal period of the time base circuit (22) is larger than the sum of the time required by the electric signal microprocessor (21) for collecting the electric signal of the infrared radiation temperature detector (1) and the time required for enabling the measuring circuit (2) and the wireless transmission circuit (5) to enter a dormant state or an electric off state.
7. A human circadian rhythm measuring device according to claim 4, characterized in that said ear cavity accommodating case (4) further comprises an infrared radiation receiving head (45); the infrared radiation receiving head (45) is in heat conduction connection with a shell of the infrared radiation temperature detector (1), an infrared light converging lens is installed on the infrared radiation receiving head (45), and the effective receiving angle of a light beam formed by combining the infrared light converging lens and the infrared radiation temperature detector (1) is not larger than 30 degrees.
CN201911417892.4A 2019-12-31 2019-12-31 Method and device for measuring human body circadian rhythm Pending CN111076843A (en)

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CN113509260A (en) * 2021-06-29 2021-10-19 哈尔滨工业大学(威海) Multi-wavelength photoacoustic temperature control method and device based on memory factor

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