CN111053975B - Cardiac pacing device, storage medium, power supply device, and output voltage control method - Google Patents
Cardiac pacing device, storage medium, power supply device, and output voltage control method Download PDFInfo
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- CN111053975B CN111053975B CN202010007012.2A CN202010007012A CN111053975B CN 111053975 B CN111053975 B CN 111053975B CN 202010007012 A CN202010007012 A CN 202010007012A CN 111053975 B CN111053975 B CN 111053975B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/378—Electrical supply
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/375—Constructional arrangements, e.g. casings
- A61N1/37512—Pacemakers
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
- H02M3/00—Conversion of dc power input into dc power output
- H02M3/02—Conversion of dc power input into dc power output without intermediate conversion into ac
- H02M3/04—Conversion of dc power input into dc power output without intermediate conversion into ac by static converters
- H02M3/06—Conversion of dc power input into dc power output without intermediate conversion into ac by static converters using resistors or capacitors, e.g. potential divider
Abstract
The invention relates to a power supply device for an implantable medical device, an output voltage control method for an implantable medical device, a cardiac pacing apparatus, and a readable storage medium. The power supply equipment comprises a power supply module and a voltage adjustment module, wherein the power supply module provides basic voltage, the voltage adjustment module comprises at least one capacitor array which can be connected with the power supply module, at least two switch capacitor units which can be connected in series or in parallel are arranged in the capacitor array, and the voltage adjustment module adjusts the output voltage of the power supply module to the required voltage by utilizing the combination and the connection mode of the switch capacitor units. The power supply device can adjust the output voltage of the power supply module by selecting different combinations and connection modes of the switch capacitor units in the capacitor array according to the required voltage, has high charge utilization efficiency, and is beneficial to prolonging the service life of the implanted medical instrument. The output voltage control method utilizes the power supply device, and the cardiac pacing apparatus includes the power supply device.
Description
Technical Field
The invention relates to the field of implantable medical devices, in particular to a cardiac pacing device, a storage medium, a power supply device and an output voltage control method.
Background
Active implanted medical devices (Active Implantable Medical Device, AIMD) refer to medical devices that are intended for use in products that are implanted in the human body, require the use of electricity, gas, etc., such as implantable cardiac pacemakers, implantable defibrillators, implantable neurostimulators, implantable bladder stimulators, implantable sphincter stimulators, implantable diaphragmatic stimulators, implantable active drug administration devices, etc.
Taking an implantable cardiac pacemaker (cardiac pacemaker) as an example, the implantable cardiac pacemaker is a medical device for generating cardiac stimulation signals, and particularly, an electric signal (namely pacing pulse) which is supplied by a battery is issued through a pulse generator, the pacing pulse is transmitted to the heart, and the heart muscle contacted by a stimulation electrode enables the heart to be excited and contracted, so that the aim of treating cardiac dysfunction such as chronic arrhythmia is fulfilled. The amplitude of the pacing pulse generated by the implanted cardiac pacemaker should meet certain requirements, namely, the pacing voltage needed for stimulating the heart to contract and beat is needed to be generated. Pacing voltages in the range of 0.5V to 7.5V are typically required. Therefore, for the power supply device for generating the pacing voltage, two problems are mainly considered, firstly, the existing pacemaker needs to be powered by a battery, the voltage of the common battery is about 2.8V, and if the pacing voltage higher than the battery voltage is to be obtained, a boosting circuit is required to be designed to boost the battery voltage; secondly, because of the individual differences of patients, the pacing voltage thresholds of the pacing voltages that the power supply device needs to generate are also different, so the power supply device needs to be able to set different pacing voltages.
However, in order to meet the use requirements of small volume and low noise of the current implantable cardiac pacemakers, the voltage of the battery is usually small. At present, in order to obtain an output voltage meeting the requirement, a charge pump circuit is conventionally adopted as a booster circuit, and when the output voltage of a power supply is not an integral multiple of the power supply voltage, the utilization efficiency of current is low, so that the service life of a battery is influenced.
Disclosure of Invention
In order to improve the current utilization efficiency of the power supply equipment of the implantable medical device and prolong the service life of the power supply equipment, the invention provides the power supply equipment of the implantable medical device. Also provided are a method of controlling an output voltage using the power supply device, a cardiac pacing apparatus including the power supply device, and a readable storage medium.
In one aspect, the invention provides a power supply device of an implantable medical device, which comprises a power supply module and a voltage adjustment module, wherein the power supply module is used for providing a basic voltage, the voltage adjustment module comprises at least one capacitor array, the capacitor array is connectable with the power supply module, at least two switch capacitor units are arranged in the capacitor array, the switch capacitor units are connected in series or in parallel, and the voltage adjustment module adjusts the output voltage of the power supply module to a required voltage by utilizing the combination and the connection mode of the switch capacitor units.
Optionally, the power supply device further includes a control module, where the control module is configured to control a connection manner between the power supply module and the capacitor array and a connection manner between the switched capacitor units.
Optionally, the voltage adjustment module includes more than two capacitor arrays, and when the switch capacitor units in each capacitor array are connected in parallel, the total capacitance of each capacitor array is the same; a corresponding switching element is arranged between each capacitor array.
Optionally, the capacitance of each switched capacitor unit in the same capacitor array is the same, and the number of switched capacitor units in each capacitor array is not exactly the same.
Optionally, the number of the switch capacitor units in each capacitor array is equal-ratio series when arranged in order from small to large.
Alternatively, when the number of the switched capacitor units in each capacitor array is arranged in order from small to large, a series increasing by the power of 2 is formed.
Optionally, each of the switched capacitor units includes a corresponding branch capacitor; corresponding switching elements are arranged between the upper polar plate of any branch capacitor and the output end of the power supply module, and between the upper polar plate and the lower polar plate of other branch capacitors in the same capacitor array; corresponding switching elements are arranged between the lower polar plate of any branch capacitor and the output end of the power supply module, between the lower polar plate and the ground, and between the lower polar plate and the upper polar plate of other branch capacitors in the same capacitor array.
Optionally, the voltage adjustment module further includes at least one boost capacitor, and a corresponding switching element is disposed between the boost capacitor and the capacitor array.
The invention provides power supply equipment of an implantable medical device, which comprises a power supply module and a voltage regulation module for regulating the output voltage of the power supply module, wherein the power supply module is used for providing a basic voltage, the voltage regulation module comprises at least one capacitor array and at least one capacitor array, the capacitor array is connected with the power supply module, at least two switch capacitor units are arranged in the capacitor array, the switch capacitor units can be switched between series connection and parallel connection, and the voltage regulation module regulates the output voltage of the power supply module to a required voltage by utilizing the combination and the connection mode of the switch capacitor units. With the power supply device, in order to obtain the required voltage, the output voltage of the power supply module can be adjusted by selecting different combinations and connection modes of the switch capacitor units in the capacitor array according to the required voltage on the basis of the basic voltage, and the adjustment precision of the output voltage can be improved by using different combinations and connection modes of the switch capacitor units, so that the output voltage of the available power supply module can be equal to or very close to the required voltage, and the charge utilization efficiency approaching to 100% can be theoretically obtained. Compared with the output voltage which is more than or equal to the required voltage, no matter whether the required voltage is integral multiple of the basic voltage or not, the power supply equipment provided by the invention has less lost charge, can obtain higher charge utilization efficiency, and is beneficial to prolonging the service life of the implanted medical instrument. In addition, the high charge utilization efficiency contributes to the improvement of durability of the power module (e.g., battery), thus facilitating further miniaturization of the implantable medical device.
In one aspect, the present invention provides a method for controlling an output voltage of an implantable medical device, implemented by using the above power supply device, the method comprising:
selecting at least one capacitor array in the voltage adjustment module according to the voltage adjustment requirement and the base voltage of the implantable medical device; connecting each switch capacitor unit in the selected capacitor array in series, charging the capacitor array by using the power module, and disconnecting the power module from the capacitor array after the capacitor array is stabilized; selecting the charged switch capacitor units respectively from different capacitor arrays according to voltage requirements, and connecting the switch capacitor units in series to form a total series capacitor; switching the high-voltage polar plate of the total series capacitor to a voltage output end, and keeping the voltage on each switch capacitor unit in the total series capacitor unchanged; and adjusting the potential on the low-voltage polar plate of the total series capacitance according to the voltage requirement, so that the voltage of the voltage output end is the required voltage.
Optionally, the capacitance of each switched capacitor unit in the same capacitor array is the same.
Optionally, the step of adjusting the potential on the low-voltage polar plate of the total series capacitor according to the voltage requirement to make the voltage of the voltage output terminal be the required voltage includes:
Comparing the required voltage with the voltage value of the total series capacitance, and when the required voltage is equal to the voltage value of the total series capacitance, regulating the potential on a low-voltage polar plate of the total series capacitance to be zero so that the voltage of the voltage output end is the required voltage; when the output voltage is increased by one basic voltage compared with the voltage value on the total series capacitance, the low-voltage polar plate of the total series capacitance is connected with the positive terminal of the power supply module, so that the voltage of the voltage output terminal is the required voltage.
Optionally, the output circuit further comprises a boost capacitor, and the boost capacitor can be connected to the total series capacitor in series; the step of adjusting the potential on the low-voltage polar plate of the total series capacitance according to the voltage requirement to enable the voltage of the voltage output end to be the required voltage comprises the following steps:
when the output voltage is increased by N times of the base voltage compared with the voltage value on the total series capacitance, connecting N boost capacitances in series with the total series capacitance; the voltage of the boost capacitor is the basic voltage, and N is an integer greater than or equal to 1.
According to the output voltage control method provided by the invention, the power supply equipment is utilized, after at least one capacitor array in the voltage adjustment module is selected for voltage adjustment, each switch capacitor unit in the selected capacitor array is connected in series, the capacitor array is charged by utilizing the power supply module, after the stability is achieved, weight voltage division is obtained on each switch capacitor unit in the capacitor array, then the connection between the power supply module and the capacitor array is disconnected, the charged switch capacitor units respectively from different capacitor arrays are selected according to voltage requirements and are connected in series to form a total series capacitor, then a high-voltage polar plate of the total series capacitor is switched to a voltage output end, the voltage on each switch capacitor unit in the total series capacitor is kept unchanged, and the potential on a low-voltage polar plate of the total series capacitor is adjusted according to the voltage requirements, so that the voltage of the voltage output end is the required voltage. The output voltage control method utilizes the power supply equipment to control the output voltage, continuous power supply is not needed in the control process, a special feedback circuit is not needed to adjust the output, the output voltage of the power supply module is adjusted by selecting different combinations and connection modes of the switch capacitor units in the capacitor array according to the size of the required voltage, the variation precision of the output voltage can be improved by utilizing the different combinations and connection modes of the switch capacitor units, and therefore the output voltage of the available power supply module can be equal to or very close to the required voltage, higher charge utilization efficiency can be obtained, and the service life of the active implanted medical instrument is prolonged.
The processing and execution of the output voltage control method are generally implemented in a software program in conjunction with a device or apparatus, however, all (or a part of them) may also be implemented in electronic hardware.
In one aspect, the present invention provides a readable storage medium having stored thereon executable instructions that, when executed by a processor, perform the above-described output voltage control method. And thus has the same or similar advantages as the above-described output voltage control method.
In one aspect, the present invention provides a cardiac pacing apparatus comprising the above-described power supply device and a pacing circuit connected to the power supply device, the power supply device being configured to provide a pacing voltage to the pacing circuit that meets pacing requirements. With the power supply device, the base voltage of the power supply module can be adjusted to the required voltage according to the pacing voltage requirement. The power supply device has high charge utilization efficiency, is beneficial to prolonging the service life of the heart pacing device, and is beneficial to realizing the miniaturization of the device.
Drawings
Fig. 1 is a schematic diagram of a power supply employing a charge pump boost circuit.
Fig. 2A to 2C are schematic diagrams of three capacitor arrays according to an embodiment of the invention.
Fig. 3 is a schematic diagram of a switched capacitor unit according to an embodiment of the invention.
Fig. 4 is a flowchart of an output voltage control method according to an embodiment of the invention.
Fig. 5 is a schematic diagram illustrating a method for controlling an output voltage to charge a first capacitor array and a second capacitor array of a series structure according to an embodiment of the present invention.
Fig. 6 is a schematic diagram of a parallel structure of a first capacitor array and a second capacitor array connected in series by using an output voltage control method according to an embodiment of the present invention.
Detailed Description
The power supply device, the output voltage control method, the cardiac pacing apparatus, and the readable storage medium of the implantable medical device of the present invention are described in further detail below with reference to the accompanying drawings and specific embodiments. The advantages and features of the present invention will become more apparent from the following description. It should be noted that the drawings are in a very simplified form and are all to a non-precise scale, merely for convenience and clarity in aiding in the description of embodiments of the invention.
Implantable medical devices are typically introduced into the human body in whole or in part by surgical procedures, or introduced into some natural orifice by medical intervention, and remain in the human body after the procedure is completed, and thus are intended for implantation in the human body and typically require electrical energy to operate, since they are required to be placed in the body for a long period of time, implantable medical devices are powered by batteries, and the volume of the batteries cannot be too large. However, since the implanted individual has different specific situations or different output voltages required by different conditions, a voltage adjusting circuit is required to be additionally provided in the implanted medical device to adjust the output voltage. Taking an implantable cardiac pacemaker as an example, the voltage of a commonly used battery is 2.8V, and when the battery is applied, a boosting circuit is often required to boost so that the output voltage of a battery system meets the pacing voltage requirement.
For the booster circuit, a DC-DC circuit or a charge pump circuit is generally employed. The DC-DC circuit needs to adopt an inductor, occupies a larger area, generates large noise, is not suitable for the small-size requirement of the implantable cardiac pacemaker, and generally adopts a charge pump circuit as a boost circuit of the implantable cardiac pacemaker.
Fig. 1 is a schematic diagram of a power supply employing a charge pump boost circuit. As shown in fig. 1, a charge pump boost circuit typically senses an output voltage V at an output H And comparing the value with a reference voltage to determine that the output voltage has reached a predetermined voltage.
However, such a charge pump booster circuit has a problem of low current utilization efficiency, since the required voltage of the pacemaker in practical application is often not an integral multiple of the battery voltage (the battery voltage is denoted as V here) BAT Integer multiple means V BAT ，2*V BAT ，3*V BAT A 2-stage boost circuit is used, for example, while the required voltage of the pacemaker needs to produce an output voltage of 1.2 v BAT When this is the case, the charge utilization efficiency can be calculated as follows: 1.2 x V BAT /(2*V BAT ) 100% = 60%. It can be seen that the charge utilization efficiency is relatively low. When used in an implantable cardiac pacemaker, due to the volume and the battery Capacity itself is limited, and low charge utilization efficiency can affect the life of the battery, so that the life of the implantable cardiac pacemaker can be affected, and replacement of the cardiac pacemaker can not only increase the cost of a patient, but also affect the life quality and health of the patient. Similar problems exist for other active implantable medical devices.
In order to solve the problems of low utilization efficiency of electric charge of a power supply and influence on the service life of a battery faced by the implantable medical device, the embodiment of the invention firstly describes the power supply equipment and the output voltage control method of the implantable medical device.
The embodiment of the invention comprises power supply equipment of an implantable medical device, wherein the power supply equipment of the implantable medical device comprises a power supply module and a voltage regulation module, wherein the power supply module is used for providing a basic voltage, the voltage regulation module comprises at least one capacitor array, the capacitor array is connectable with the power supply module, at least two switch capacitor units are arranged in the capacitor array, the switch capacitor units are connected in series or in parallel, and the voltage regulation module regulates the output voltage of the power supply module to a required voltage by utilizing the combination and the connection mode of the switch capacitor units.
With the power supply device of this embodiment, in order to obtain the required voltage, the output voltage of the power supply module may be adjusted by selecting different combinations and connection modes of the switched capacitor units in the capacitor array according to the required voltage based on the required voltage, and the adjustment accuracy of the output voltage may also be adjusted by using different combinations and connection modes of the switched capacitor units, for example, if the output voltage to be generated is 1.2×vbat (VBAT represents the base voltage provided by the power supply module), the power supply device of this embodiment does not need to generate 2×vbat first, but may split 1.2×vbat into the sum of several weight partial pressures, based on the base voltage provided by the power supply module, combine and connect the switched capacitor units, and obtain the partial pressure of less than 1 base voltage therein through the formed capacitor array, and then concatenate the weight partial pressures with integer multiples, so as to obtain the voltage value close to or equal to the output voltage from the concatenated total port voltage. The output voltage of the power supply module that is available may thus be equal to or very close to the required voltage. As can be seen, the power supply apparatus of the present embodiment can theoretically achieve a charge utilization efficiency close to 100% regardless of whether the required voltage is an integer multiple of the base voltage or not, with respect to the power supply of the charge pump boosting mode as shown in fig. 1. Of course, the charge utilization efficiency that can be obtained in practice is lower than 100% considering that there is some loss in the actual circuit.
Therefore, with the power supply device of the embodiment, the charge utilization efficiency can be greatly improved compared with the existing scheme, and the service life of the implantable medical device is prolonged. In addition, when the implantable medical device is designed, the requirement on the size of the device can be reduced by prolonging the service life of the battery, and the implantable medical device with further miniaturization can be obtained.
The combination and connection mode of each switch capacitor unit in the voltage adjustment module can be controlled by a hardware circuit or software, specifically, the above-mentioned implanted power supply system may further include a control module, where the control module is configured to control connection between the power supply module and the voltage adjustment module, and connection between the switch capacitor units in the voltage adjustment module, so as to perform automatic control, such as programming control, on the above-mentioned power supply device, so that an output voltage of the power supply device is adjustable.
The power module in the above-mentioned implantable power supply can be a battery or a battery pack, for example, a lithium ion battery, and its function is to output a fixed voltage, defined as the basic voltage V BAT . Taking an implantable cardiac pacemaker as an example, the base voltage V BAT For example, but not limited thereto, 2.8V, the base voltage may be determined by the structure of the power module.
More than one capacitor array, for example, more than two capacitor arrays, may be provided in the voltage adjustment module according to the output voltage requirement in a specific application. Typically, to improve the flexibility of adjusting the output voltage and the voltage adjustment accuracy, the voltage adjustment module includes more than two capacitor arrays. For more than two capacitor arrays, in order to obtain a required output voltage by connecting different capacitor arrays in series, in this embodiment, the voltage adjustment module includes more than two capacitor arrays, and when the switch capacitor units in each capacitor array are connected in parallel, the total capacitance of each capacitor array is the same; a corresponding switching element is arranged between each capacitor array. In addition, in order to facilitate the combination and control of the switched capacitor units, the capacitances of the switched capacitor units in the same capacitor array in this embodiment are all the same, and in order to further improve the flexibility of the output voltage and the voltage regulation precision, the number of the switched capacitor units in each capacitor array is preferably not completely the same. In this embodiment, the voltage adjustment accuracy is related to the number of switched capacitor units in the capacitor array, and the following output voltage control method will be further described.
Fig. 2A to 2C are schematic diagrams of three capacitor arrays according to an embodiment of the invention. As shown in fig. 2A to 2C, in an embodiment, the power supply device of the implantable medical device includes three capacitor arrays, that is, a first capacitor array including eight switch capacitor units (fig. 2A), a second capacitor array including four switch capacitor units (fig. 2B), and a third capacitor array including two switch capacitor units (fig. 2C), respectively. In each capacitor array, the switch capacitor units can be disconnected, or part or all of the switch capacitor units can be connected in series according to the requirement, or can be connected in parallel.
In this embodiment, the total capacitance of each capacitor array when all the switch capacitor units are connected in parallel is set to be the same, and denoted as C, and the capacitances of the switch capacitor units in the same capacitor array are also the same, so that the capacitances of the eight switch capacitor units in the first capacitor array are all C/8 (i.e., the first capacitor switch capacitor unit), the capacitances of the four switch capacitor units in the second capacitor array are all C/4 (i.e., the second capacitor switch capacitor unit), and the capacitances of the two switch capacitor units in the third capacitor array are all C/2 (i.e., the third capacitor switch capacitor unit). In this embodiment, the capacitance of each switched capacitor unit in the same capacitor array in the voltage adjustment module is the same, but the present invention is not limited thereto, and in another embodiment, the same capacitor array may also include switched capacitor units with different capacitances.
Specifically, for any one of the first to third capacitor arrays, when the switched capacitor units are connected in series, when an applied voltage is applied to the capacitor array, the voltages distributed across the respective switched capacitor units are equal, and theoretically, the applied voltage is divided by the number of the switched capacitor units. In this embodiment, the applied voltage is a basic voltage V output by the power module BAT Then, after stabilization, for the first capacitor array, the voltage difference formed across each switch capacitor unit is V BAT For the second capacitor array, the voltage difference formed on each switch capacitor unit is V BAT For the third capacitor array, the voltage difference formed on each switch capacitor unit is V BAT /2. At this time, when the switch capacitor units in each capacitor array are switched to be connected in parallel, the total voltage of each capacitor array is the voltage difference on each switch capacitor unit, and the voltage difference can be used as the weight voltage obtained by the corresponding capacitor array.
In this embodiment, the number of the switched capacitor units in the first to third capacitor arrays is gradually decreased in a halving manner, and the obtained weight voltage is also increased in multiple, so that when the output voltage is calculated by counting the weight voltages, the output voltage can be continuously adjusted with the minimum weight voltage as the adjustment precision. In another embodiment, the number of the switched capacitor units in each capacitor array is also equal-ratio series when arranged in order from small to large, but may be different from the present embodiment, for example, may be a regular variation of 5, 10, 20. In another embodiment, the number of switched capacitor cells in each of the capacitor arrays is arranged in order from small to large to form a series that increases to the power of 2. Namely, the binary regular change is utilized, so that the programming control of the digital circuit is facilitated. It can be understood that the capacitor arrays in the voltage adjustment module may also include more than eight switch capacitor units, and the number of the capacitor arrays and the number of the switch capacitor units in each capacitor array may be determined according to factors such as the adjustment accuracy requirement of the output voltage and the complexity of the voltage adjustment module.
In the above embodiments, the voltage adjustment module may further include at least one boost capacitor in addition to one or more capacitor arrays. The boost capacitor is, for example, a single switched capacitor unit, and its capacitance may be set to be the same as the total capacitance of the capacitor array forming the weight division voltage, so that after the boost capacitor is fully charged, it may also be connected in series with the capacitor array forming the weight division voltage according to the requirement of the output voltage to increase the port voltage. In this embodiment, the capacitance of the boost capacitor is the same as the capacitance of the capacitor array when the switch capacitor units in each capacitor array are connected in parallel (i.e., the capacitance after the weight voltage division is formed), and is denoted as C. For the boost capacitor, the basic voltage V is applied BAT When the voltage difference formed on the upper and lower polar plates is V BAT It can be seen that its corresponding weight voltage is equal to the base voltage V BAT 。
In this embodiment, the switch capacitor unit on the voltage adjustment module is a branch capacitor, so that the capacitances of the branch capacitors in the first to third capacitor arrays are different and are respectively C/8, C/4 and C/2, and the specific capacitance value of the branch capacitor can be specifically selected according to the requirements of the adjustment accuracy of the output voltage, etc.
In this embodiment, each of the switched capacitor units includes a corresponding branch capacitor C1; corresponding switching elements are arranged between the upper polar plate of any branch capacitor C1 and the output end of the power supply module, and between the upper polar plate and the lower polar plate of other branch capacitors in the same capacitor array; the lower polar plate of any branch capacitor is arranged between the lower polar plate of any branch capacitor and the output end of the power supply module, between the lower polar plate of any branch capacitor and the ground, and the same capacitor array. The upper plate of the branch capacitor refers to a plate with higher voltage when a voltage difference is formed, and the upper plate also serves as a high-voltage plate corresponding to the switch capacitor unit. The lower plate of the branch capacitor refers to a plate with lower voltage when a voltage difference is formed, and the lower plate also serves as a low-voltage plate of a corresponding switch capacitor unit.
A respective switching element may be provided between each of the branch capacitances to facilitate the series or parallel connection of the switched capacitance units. Fig. 3 is a schematic diagram of a switched capacitor unit according to an embodiment of the invention. As shown in fig. 3, for example, each switched capacitor unit may be connected to other switched capacitor units or other ports in a circuit through six switch elements, where C1 represents a branch capacitor, and the capacitance of the branch capacitor C1 may be selected as required, and the connection relationships represented by the connection ends are as follows:
V BAT -connecting a supply voltage;
V P -connecting the lower plate or lower plate of the other capacitor;
V H -a holding capacitor (for holding a required voltage);
GND-ground;
V N -connecting the upper or lower plate of the other capacitor.
It can be seen that in this embodiment, in the same capacitor array, each switched capacitor unit may be connected in series, that is, the lower plate of the previous switched capacitor unit is connected to the upper plate of the next switched capacitor unit, the upper plate of the foremost switched capacitor unit is used as the high-voltage plate of the capacitor array with the series structure, and the lower plate of the last switched capacitor unit is used as the low-voltage plate of the capacitor array with the series structure. In addition, in the same capacitor array, each switch capacitor unit can be connected in parallel, namely the upper polar plates of each switch capacitor unit are connected with each other, the lower polar plates of each switch capacitor unit are also connected with each other, the high-voltage polar plate of the capacitor array with the parallel structure formed is the upper polar plate of any switch capacitor unit, and the low-voltage polar plate is the lower polar plate of any switch capacitor unit.
In addition, as shown in fig. 3, in this embodiment, in order to maintain the obtained output voltage, the upper plate of the bypass capacitor C1 may be further connected to a holding capacitor through a switching element, where the holding capacitor is used to provide a voltage to the electric device, for The applied voltage is V H . For example, when applied to an implantable cardiac pacemaker, the holding capacitance may act as a pacing capacitance, the voltage across which is applied by a pulse generator to the heart with pacing pulses. It should be noted that, the output voltage of the power supply device may be obtained from the upper plate of one switched capacitor unit near the output end in the output circuit, so in another embodiment, only a part of the upper plate of the switched capacitor unit may be disposed between the upper plate and the holding capacitor, that is, the adjusted required voltage may be output through a part of the switched capacitor unit. The switching elements disposed on the upper and lower plates of each branch capacitor C1 and between the respective capacitor arrays may be one of switching elements such as transistors, MOSFETs, JFETs, IGBTs, and the like. The active switching element is convenient to automatically control, and can be manufactured on a chip through an integrated circuit process and a branch capacitor, and the parasitic capacitance is small and the size is small. In some embodiments, one or more of the switching elements may also employ passive switching devices, such as magnetically controlled switches or the like. It should be noted that, in the present embodiment, when no external electric field is applied to the voltage difference across the switch capacitor units, the switching element should be turned on or off so as not to affect the original voltage across each switch capacitor unit, so that factors such as parasitic capacitance, which are easy to consume the charge amount across the switch capacitor units, should be avoided in selecting the switch element.
The voltage adjustment module in the embodiment can adopt a full-on-chip integrated design mode, does not need to add additional off-chip discrete components, reduces the cost, can reduce the design complexity of the hybrid circuit board and increases the reliability.
The embodiment also comprises an output voltage control method of the implantable medical device, which can be realized by adopting the power supply equipment of the implantable medical device. Fig. 4 is a flowchart of an output voltage control method according to an embodiment of the invention. Referring to fig. 4, the output voltage control method includes the steps of:
step S1: selecting at least one capacitor array in the voltage adjustment module according to the voltage adjustment requirement and the base voltage of the implantable medical device;
step S2: connecting each switch capacitor unit in the selected capacitor array in series, charging the capacitor array by using the power module, and disconnecting the power module from the capacitor array after the capacitor array is stabilized;
step S3: selecting the charged switch capacitor units respectively from different capacitor arrays according to voltage requirements, and connecting the switch capacitor units in series to form a total series capacitor;
step S4: switching the high-voltage polar plate of the total series capacitor to a voltage output end, and keeping the voltage on each switch capacitor unit in the total series capacitor unchanged;
Step S5: and regulating the potential on the low-voltage polar plate of the total series capacitor according to the voltage requirement, so that the voltage of the voltage output end is the required voltage.
As an example, the above power supply device having three capacitor arrays as in fig. 2A to 2C is employed to generate 1.375 times the basic voltage V BAT As an output voltage (i.e. 1.375 x v BAT ) For example, the above-described output voltage control method using an implantable medical device will be described.
First, step S1 is performed to select a capacitor array. Specifically, as an example, the capacitance of each of the switch capacitor units in any one of the three capacitor arrays is set to be the same, and thus the weight voltage that can be obtained with each capacitor array is related to the number of switch capacitor units. Specifically, the base voltage may be divided by the number of switched capacitor units in each capacitor array, the obtained value is used as a predicted value of the weight voltage of the corresponding capacitor array, and then at least one capacitor array in the voltage adjustment module is selected to execute the following steps according to the predicted value of the weight voltage and the output voltage to be obtained. In this embodiment, the number of switched capacitor cells in each capacitor array is determined. It should be understood that in another embodiment, the number of capacitor arrays in the power supply device is not determined, and the number of switched capacitor units included in the capacitor arrays may be selected according to the requirement when the output voltage control is performed.
In this embodiment, according to the above calculation method, it is known that the predicted value of the weight voltage corresponding to the first capacitor array is V BAT And/8, the predicted value of the weight voltage corresponding to the second capacitor array is V BAT And/4, the predicted value of the weight voltage corresponding to the third capacitor array is V BAT 2, and the output voltage to be obtained is 1.375 v BAT According to 1/8+1/4=0.375, i.e. the sum of the weighted voltages of the first capacitor array and the second capacitor array may cover a fraction (i.e. a non-integer multiple) of the required output voltage, thus one first capacitor array and one second capacitor array may be selected, which are connected in the output circuit via the switching element. The output circuit includes a circuit connected to a voltage output terminal, for example, the voltage output terminal of the output circuit may be disposed at a node between the capacitor array and the holding capacitor. A series node is arranged between the first capacitor array and the second capacitor array, and a switching element is arranged at the series node. In step S1, the switching elements at the series node are open, since the individual switched capacitor cells have not yet been charged.
In another embodiment, the output voltage to be obtained is another value, and only one capacitor array may be selected to be disposed in the output circuit. For example, if the output voltage to be obtained is 1.25 v BAT Only one second capacitor array may be selected to obtain a non-integer portion of the output voltage of 0.25 v BAT . In another embodiment, the output voltage to be obtained is 1.5 v BAT Only one third capacitor array may be selected to obtain a non-integer portion of the output voltage of 0.5 v BAT Two second capacitor arrays may also be selected to obtain a non-integer portion of the output voltage of 0.5 v BAT Considering that an increase in the number of switched capacitor cells increases some energy losses and increases the volume, the list here achieves 0.5 v BAT In the two capacitor array selection modes, a scheme of adopting a third capacitor array is better. In another embodiment, the output voltage to be obtained is 0.875 v BAT A first capacitor array, a second capacitor array and a third capacitor array can be selectedRong Zhenlie after the subsequent steps, the total weight voltage is (1/8+1/4+1/2) V BAT I.e. the required output voltage.
In this embodiment, since the maximum number of switch capacitor units in the first capacitor array is eight, the output voltage adjusting accuracy is V BAT I.e. the minimum variation of the output voltage. However, this is merely an example, and in other embodiments, sixteen, thirty-two, etc. more switched capacitor units may be provided in the capacitor array to improve the voltage regulation accuracy, depending on the output voltage accuracy requirements.
In the case where the capacitor array for obtaining the weight division is selected (a first capacitor array and a second capacitor array in this embodiment, the output voltage to be obtained is 1.375 v BAT ) After that, step S2 is performed next. Fig. 5 is a schematic diagram illustrating a method for controlling an output voltage to charge a first capacitor array and a second capacitor array of a series structure according to an embodiment of the present invention. Referring to fig. 5, in step S2, the switched capacitor units in the first capacitor array and the second capacitor array are connected in series, i.e. for the first capacitor array, all eight switched capacitor units are connected in series in the order of the lower plate of the previous switched capacitor unit to the upper plate of the next switched capacitor unit, and then the upper and lower plates of the series structure are connected to the output of the power module (via connection to V in fig. 3 BAT And ground (via the switch connected to GND in fig. 3), the respective switched capacitor cells are charged by the power supply module (the other switching elements on the switched capacitor cells are in an off state), and after stabilization, the voltage difference across each of the switched capacitor cells in the first capacitor array is V BAT For the second capacitor array, all four switch capacitor units are connected in series according to the sequence that the lower electrode plate of the former switch capacitor unit is connected with the upper electrode plate of the latter switch capacitor unit, then the upper electrode plate and the lower electrode plate of the series structure are respectively connected to the output end of the power supply module and the ground, the power supply module charges each switch capacitor unit, and after stabilizing, the voltage difference on each switch capacitor unit in the second capacitor array is V BAT /4. At the position ofAfter charging, the connection between the power module and the selected capacitor array is disconnected, i.e. the charging of the first capacitor array and the second capacitor array is stopped, and at this time, the voltage difference across each switch capacitor unit in the array remains substantially unchanged.
Step S3 is executed, the charged switch capacitor units in different capacitor arrays are selected according to the voltage requirement and are connected in series to form the total series capacitor.
Specifically, in order to keep the series capacitance elements in the total series capacitance unchanged in voltage after series connection, the capacitance of each series capacitance element should be the same. Therefore, in the present embodiment, eight switched capacitor units in the first capacitor array are switched from serial connection to parallel connection, and four switched capacitor units in the second capacitor array are switched from serial connection to parallel connection, that is, upper plates of all the switched capacitor units in the same capacitor array are electrically connected together, and lower plates of all the switched capacitor units are electrically connected together (other switched elements on the switched capacitor units are in an off state). For the first capacitor array and the second capacitor array which form the parallel structure, the total capacitance is C, so that the charging voltage on each switch capacitor unit can be kept stable and unchanged after the first capacitor array and the second capacitor array are connected in series. After switching to parallel connection, the total voltage difference of the capacitor array is the voltage difference of each switch capacitor unit, i.e. the weight voltage division of the first capacitor array of the parallel structure is V BAT And/8, the weight partial pressure on the second capacitor array of the parallel structure is V BAT /4。
Fig. 6 is a schematic diagram of a parallel structure of a first capacitor array and a second capacitor array connected in series by using an output voltage control method according to an embodiment of the present invention. Referring to FIG. 6, in this embodiment, the total series capacitance includes a first capacitor array and a second capacitor array connected in series, and the voltage difference across the total series capacitance is the sum of the partial voltages of the two capacitor arrays, here (1/8+1/4) V BAT ＝0.375*V BAT 。
Then step S4 is executed to switch the high-voltage polar plate of the total series capacitance to the voltage output end for protectionThe voltage on each of the switched capacitor units in the total series capacitance is maintained unchanged. In this embodiment, the high-voltage electrode plate of the total series capacitor is an upper electrode plate of any one of the switched capacitor units in the first capacitor array. The switching element between the upper plate of the switched capacitor unit and the holding capacitor may be closed, and the potential on the holding capacitor is the same as the potential of the upper plate of the switched capacitor unit. The low-voltage polar plate of the total series capacitor is the lower polar plate of any one of the switch capacitor units in the second capacitor array, and the voltage difference between the voltage output end and the low-voltage polar plate of the total series capacitor is 0.375V which is the non-integral part of the required voltage BAT 。
Through the steps, the non-integral multiple part of the output voltage is obtained, and then the integral multiple basic voltage can be added to the total series capacitance, so that the required output voltage can be obtained.
And step S5, according to the voltage requirement, regulating the potential on the low-voltage polar plate of the total series capacitor to enable the voltage of the voltage output end to be the required voltage. Specifically, in step S5, the required voltage and the voltage value of the total series capacitor may be compared, and when the required voltage is equal to the voltage value of the total series capacitor, the potential on the low-voltage polar plate of the total series capacitor is adjusted to be zero, so that the voltage at the voltage output end is the required voltage; when the output voltage is increased by one or more integral multiples of the base voltage compared with the voltage value on the total series capacitor, a method may be adopted, in which a low-voltage polar plate of the total series capacitor is connected to the positive terminal of the power module, so that the voltage at the voltage output end is the required voltage, and the voltage at the voltage output end can be increased by one base voltage, and a method may be adopted, in which the boost capacitor in the power supply device described in the embodiment is utilized, the boost capacitor may be connected to the total series capacitor in series, and by connecting the boost capacitor with the integral multiple of the charging voltage as the base voltage in series with the total series capacitor, the voltage at the voltage output end is the required voltage, and the voltage at the voltage output end may be increased by one or more integral multiples of the base voltage by using the boost capacitor. Thus when the output voltage is increased by a factor of N (N is an integer equal to or greater than 1) by a base voltage compared to the voltage value across the total series capacitance, N boost capacitors can be connected in series with the total series capacitance, wherein the voltage of the boost capacitors is the base voltage. The invention is not limited thereto, and the disclosed method may be adopted to increase the base voltage by an integer multiple.
In the present embodiment, 1.375 v is obtained as an example BAT Is subjected to step S4 to obtain 0.375 v BAT Then, increasing the base voltage by an integer multiple can be achieved by one of the following methods:
the first method is that for an integral multiple voltage of the basic voltage, the basic voltage can be directly applied to the lower electrode plate of the total series capacitance formed by the first capacitor array and the second capacitor array through the power module, namely, the lower electrode plate of the total series capacitance is connected with the positive electrode end of the power module, so that the voltage of the lower electrode plate of the total series capacitance is raised to V BAT According to the characteristics of the total series capacitance, the voltage difference between the upper polar plate and the lower polar plate of the total series capacitance is kept unchanged and is still 0.375V BAT After stabilization is achieved, the upper plate of the total series capacitance becomes 1.375 v BAT The required voltage can be obtained from the voltage output end;
in the second method, a boost capacitor is arranged in the output circuit, the capacitance of the boost capacitor can be selected to be the same as the total capacitance (C in this embodiment) obtained when the selected capacitor array is connected in parallel with each switch capacitor unit, and when the step S2 is executed, the power supply module is used to fully charge the boost capacitor to make the boost capacitor have a voltage difference V BAT When executing step S5, the switching element between the boost capacitor and the first capacitor array and/or the second capacitor array is closed, that is, the boost capacitor can be connected in series to the total series capacitor, and for the total series capacitor formed by the first capacitor array, the second capacitor array and the boost capacitor, the sum of voltage differences is 1.375 v BAT Then, the voltage connected from the upper plate of the total series capacitanceThe level of the output terminal rises and the voltage that can be obtained by the voltage output terminal is 1.375 v BAT The required voltage is obtained.
The first method for increasing the base voltage by integer multiple uses the power module to increase the voltage of the lower electrode plate of the total series capacitance, so that the voltage of the upper electrode plate can be increased by a base voltage, and the base voltage V is usually applied to an implantable cardiac pacemaker BAT With this approach, a power supply voltage output of 0 to 2 times can be produced, which can already cover a wide range of pacing voltage output requirements, at 2.8V. In addition, by using the second method for increasing the base voltage by an integer multiple, the voltage at the voltage output terminal can be increased by more than two base voltages by providing more than two boost capacitors.
The two methods for increasing the integral multiple of the base voltage can be used at the same time, and according to the design of the power supply device, the base voltage can be increased by one integral multiple through the first method, the base voltage can be increased by one or more integral multiple through the second method, and the required output voltage (namely the required voltage) can be obtained from the voltage output terminal.
The output voltage obtained by the output voltage control method can be obtained on the holding capacitor through the voltage output end, the upper polar plate of the holding capacitor is connected with the voltage output end, the lower polar plate of the holding capacitor is connected with the negative electrode of the power supply module, the holding capacitor can be used as a pacing capacitor for an implantable cardiac pacemaker, and the voltage of the voltage output end drops after one pacing pulse, and at the moment, the voltage acquisition method needs to be re-executed to obtain the required output voltage.
The processing and execution of the output voltage control method of the power supply device may be mainly performed by software in a programming manner or may be realized by a circuit manner.
The present embodiment also includes a readable storage medium having stored thereon executable instructions that, when executed by a processor, perform the output voltage control method of the power supply device described above. The processor may be a CPU in a microcomputer, and the readable storage medium may be a Random Access Memory (RAM), a random Read Only Memory (ROM), a hard disk, a magnetic disk, an optical disk, a register in a Central Processing Unit (CPU), or the like.
The power supply device and the output voltage control method of the implantable medical device described in the embodiment can adjust the output voltage of the power supply module to the required voltage through the voltage adjustment module. The output voltage of the power supply module is adjusted according to different combinations and connection modes of the switch capacitor units in the capacitor array, and the variation accuracy of the output voltage can be improved by using different combinations and connection modes of the switch capacitor units, so that the output voltage of the available power supply module can be equal to or very close to the required voltage, higher charge utilization efficiency can be obtained, and the charge utilization efficiency can reach 100% theoretically.
The embodiment additionally comprises a cardiac pacing device, wherein the cardiac pacing device comprises the power supply equipment of the implantable medical device and a pacing circuit connected with the power supply equipment, and the power supply equipment is used for providing pacing voltage meeting pacing requirements for the pacing circuit. By using the implantable power supply device, the output voltage of the power supply device can be regulated according to the pacing voltage requirement, and the charge utilization efficiency of the output voltage is higher on the basis of the base voltage, so that on one hand, under the condition that the capacity of a battery is limited, the service life of the cardiac pacing device can be prolonged, on the other hand, the battery volume can be reduced, the implantable power supply device can be applied to the structures of various cardiac pacing devices, and the cardiac pacing device can be a leadless implantable cardiac pacemaker and is beneficial to prolonging the service life of the leadless implantable cardiac pacemaker.
The foregoing description is only illustrative of the preferred embodiments of the present invention, and is not intended to limit the scope of the claims, and any person skilled in the art may make any possible variations and modifications to the technical solution of the present invention using the method and technical content disclosed above without departing from the spirit and scope of the invention, so any simple modification, equivalent variation and modification made to the above embodiments according to the technical matter of the present invention fall within the scope of the technical solution of the present invention.
Claims (13)
1. A power supply apparatus for an implantable medical device, comprising:
the power module is used for providing a basic voltage; the method comprises the steps of,
the voltage adjusting module comprises at least one capacitor array, the capacitor array and the power supply module can be connected, wherein at least two switch capacitor units are arranged in the capacitor array, the switch capacitor units are connected in series or in parallel, and the voltage adjusting module adjusts the output voltage of the power supply module to the required voltage by utilizing the combination and the connection mode of the switch capacitor units;
each switch capacitor unit comprises a corresponding branch capacitor; corresponding switching elements are arranged between the upper polar plate of any branch capacitor and the output end of the power supply module, and between the upper polar plate and the lower polar plate of other branch capacitors in the same capacitor array; corresponding switching elements are arranged between the lower polar plate of any branch capacitor and the output end of the power supply module, between the lower polar plate and the ground, and between the lower polar plate and the upper polar plate of other branch capacitors in the same capacitor array.
2. The power supply apparatus according to claim 1, further comprising:
and the control module is used for controlling the connection mode between the power supply module and the capacitor array and the connection mode between the switch capacitor units.
3. The power supply apparatus according to claim 1, wherein the voltage adjustment module includes two or more of the capacitor arrays, and when the switched capacitor units in each of the capacitor arrays are connected in parallel, the total capacitance of each of the capacitor arrays is the same; a corresponding switching element is arranged between each capacitor array.
4. A power supply device as claimed in claim 3, characterized in that the capacitances of the switched capacitor units in the same capacitor array are all identical, and the number of switched capacitor units in each capacitor array is not exactly the same.
5. The power supply apparatus according to claim 4, wherein the number of the switched capacitor units in each of the capacitor arrays is equal-ratio series when arranged in order from small to large.
6. The power supply apparatus according to claim 5, wherein the number of switched capacitor units in each of said capacitor arrays is arranged in order from small to large to form a series increasing by a power of 2.
7. The power supply apparatus according to any one of claims 1 to 6, wherein the voltage adjustment module further comprises at least one boost capacitor, between which a respective switching element is arranged with the capacitor array.
8. An output voltage control method of an implantable medical device, implemented using the power supply apparatus according to any one of claims 1 to 7, characterized in that the output voltage control method comprises:
selecting at least one capacitor array in the voltage adjustment module according to the voltage adjustment requirement and the base voltage of the implantable medical device;
connecting each switch capacitor unit in the selected capacitor array in series, charging the capacitor array by using the power module, and disconnecting the power module from the capacitor array after the capacitor array is stabilized;
selecting the charged switch capacitor units respectively from different capacitor arrays according to voltage requirements, and connecting the switch capacitor units in series to form a total series capacitor;
switching the high-voltage polar plate of the total series capacitor to a voltage output end, and keeping the voltage on each switch capacitor unit in the total series capacitor unchanged;
And regulating the potential on the low-voltage polar plate of the total series capacitor according to the voltage requirement, so that the voltage of the voltage output end is the required voltage.
9. The method of claim 8, wherein the capacitances of the switched capacitor cells in the same capacitor array are all the same.
10. The method of claim 8, wherein the step of adjusting the potential on the low voltage plate of the total series capacitance to make the voltage at the voltage output terminal be the required voltage according to the voltage requirement comprises:
comparing the voltage value of the demand voltage and the total series capacitance, and,
when the required voltage is equal to the voltage value of the total series capacitance, regulating the potential on a low-voltage polar plate of the total series capacitance to be zero so that the voltage of the voltage output end is the required voltage;
when the output voltage is increased by one basic voltage compared with the voltage value on the total series capacitance, the low-voltage polar plate of the total series capacitance is connected with the positive terminal of the power supply module, so that the voltage of the voltage output terminal is the required voltage.
11. The output voltage control method of claim 8, wherein the voltage regulation module further comprises a boost capacitor connectable in series to the total series capacitor;
The step of adjusting the potential on the low-voltage polar plate of the total series capacitance according to the voltage requirement to enable the voltage of the voltage output end to be the required voltage comprises the following steps:
when the output voltage is increased by N times of the base voltage compared with the voltage value on the total series capacitance, connecting N boost capacitances in series with the total series capacitance;
the voltage of the boost capacitor is the basic voltage, and N is an integer greater than or equal to 1.
12. A readable storage medium having stored thereon executable instructions which, when executed by a processor, perform the output voltage control method of any of claims 8 to 11.
13. A cardiac pacing apparatus comprising a power supply device according to any one of claims 1 to 7 for providing a pacing voltage to the pacing circuit that meets pacing requirements, and a pacing circuit connected to the power supply device.
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| CN111053975B (en) * | 2020-01-03 | 2023-09-29 | 创领心律管理医疗器械（上海）有限公司 | Cardiac pacing device, storage medium, power supply device, and output voltage control method |
| CN112468746B (en) * | 2020-11-13 | 2023-04-07 | 中国电子科技集团公司第二十四研究所 | Focal plane digital pixel gain fine-tuning circuit |
| TWI777339B (en) * | 2020-12-28 | 2022-09-11 | 財團法人工業技術研究院 | Electrical stimulation device and method |
| CN112843473B (en) * | 2020-12-30 | 2023-08-04 | 创领心律管理医疗器械（上海）有限公司 | Cardiac pacing system |
| CN113069688B (en) * | 2021-03-29 | 2024-04-05 | 上海力声特医学科技有限公司 | Power supply module of artificial cochlea implant |
| CN114094869B (en) * | 2021-11-23 | 2024-01-09 | 融和医疗科技(浙江)有限公司 | Circuit and method for realizing pulsed electric field technology |
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