CN111053882A - Chinese herbal medicine preparation for treating leucoderma and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese herbal medicine for treating vitiligo, which is prepared from 5-20 parts of forsythia, 3-10 parts of angelica dahurica, 3-10 parts of angelica, 3-10 parts of liquorice, 2-8 parts of lithospermum, 3-10 parts of polygonum multiflorum, 3-10 parts of privet, 3-10 parts of tribulus terrestris, 1-5 parts of salvia miltiorrhiza bunge, 1-5 parts of mangnolia officinalis, 3-10 parts of radix asparagi, 1-5 parts of holly, 3-10 parts of pseudo-ginseng, 1-5 parts of rhizoma atractylodis and 1-5 parts of dried ginger slice; the invention also provides a preparation method of the Chinese herbal medicine preparation for treating leucoderma, which comprises the following steps: s1, processing the raw material medicaments into fine powder: s2, accurately weighing all the medicaments according to the proportion and mixing, wherein each medicament is 900 g. The invention discloses a lotus seed and forsythia for treating blood diseases: radix angelicae, angelica sinensis and caltrop are used for breaking blood and removing stasis, nourishing new blood, dispelling wind and removing dampness: licorice root, radix Glycyrrhizae tonifies the spleen and qi, clears heat and removes dampness: the lithospermum and the salvia miltiorrhiza have the effects of strengthening the middle-jiao and tonifying qi: rhizoma atractylodis is mainly used for treating dead muscle spastic jaundice: meanwhile, magnolia officinalis, radix asparagi, holly and pseudo-ginseng are added to promote tissue regeneration and beautify: the medicines are used together to have the effects of regulating qi and blood, breaking blood and removing blood stasis, and nourishing new blood and skin, and can effectively treat leucoderma.

Description

Chinese herbal medicine preparation for treating leucoderma and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a Chinese herbal medicine preparation for treating leucoderma and a preparation method thereof.

Background

Vitiligo is a common acquired limited or generalized skin depigmentation disease. The disease has small influence on the physical function of the patient, but has immeasurable serious influence on the normal social life of the patient. The modern medicine considers that the cause of the disease is unknown, no effective method for treating the leucoderma exists at home and abroad till now, and a more reasonable treatment scheme can be selected only according to different clinical manifestations.

The traditional Chinese medicine has obvious treatment effect on the leucoderma, and doctors of all generations in the past accumulate a great deal of practical experience for treating the leucoderma from qi-blood disharmony. Qi and blood are two main substances in the human body, and play an important role in the life activities of the human body, and have the effects of promoting regulation, warming, cooling and moistening, defense, consolidating and mediating: blood has nourishing and refreshing effects on human body.

Qi and blood deficiency can cause malnutrition of the body, and is often manifested by lassitude, shortness of breath, laziness in speaking, pale or sallow complexion, dizziness, pale lips and nails, palpitation, insomnia, pale tongue and weak pulse. At present, people with common deficiency of qi and blood are increasing in clinic, and medicaments for tonifying qi and nourishing blood in markets of various manufacturers comprise traditional Chinese medicine preparations and Chinese and western medicine combined preparations, but have the advantages of long period, poor effect and high price in administration, are not ideal medicaments for patients, and have two causes of the existing pathogenic wind: one is caused by a low congenital ratio and by an imbalance of the mother body during the development of spermatozoa. The second is that 18-60 years old patients are mainly caused by yin-yang deficiency and blood degeneration caused by yin-yang deficiency in spring and summer and yin-yin deficiency in autumn and winter. It is manifested as skin discoloration and the search for a treatment for the root cause of disease (compendium of materia Medica). Realizing ascending, descending, sinking, floating, transforming, harvesting, storing, treating, descending, generating and counteracting.

Disclosure of Invention

The invention aims to solve the problem that the prior art has defects to break through, and provides a Chinese herbal medicine preparation for treating leucoderma and a preparation method thereof, wherein the Chinese herbal medicine preparation is prepared by applying the fructus forsythiae to treat blood diseases: radix Angelicae Dahuricae, radix Angelicae sinensis, and fructus Tribuli for removing blood stasis, promoting health, promoting hematopoiesis, dispelling pathogenic wind, and removing dampness; licorice root, radix Glycyrrhizae tonifies the spleen and qi, clears heat and removes dampness: radix Arnebiae and Saviae Miltiorrhizae radix have effects in invigorating middle warmer and invigorating qi; rhizoma Atractylodis is used for treating dead muscle convulsion; meanwhile, magnolia officinalis, radix asparagi, holly and pseudo-ginseng are added to promote tissue regeneration and keep young; the medicines are used together to have the effects of regulating qi and blood, breaking blood and removing stasis, and nourishing new blood and skin, and can effectively treat leucoderma; selecting natural edible plant medicines with homology of medicinal diet as raw materials, wherein all the components conform to the regulations of the pharmacogenetic law; the comprehensive effects of the traditional Chinese medicines are utilized to treat the vitiligo related to qi and blood malignant change, coronary blood consolidation, rheumatism invasion, dead muscle convulsion and skin malnutrition, no chemical sweetener is used, and the traditional Chinese medicine is non-toxic and harmless to a human body; the instant granules are rich in nutrition and convenient to drink, and meet the regulations of the national food sanitation law; it can also be drunk by normal people for strengthening body constitution.

In order to achieve the purpose, the invention adopts the following technical scheme:

a Chinese herbal medicine for treating leucoderma is prepared from 5-20 parts of fructus forsythiae, 3-10 parts of radix angelicae, 3-10 parts of angelica sinensis, 3-10 parts of liquorice, 2-8 parts of lithospermum, 3-10 parts of polygonum multiflorum, 3-10 parts of privet, 3-10 parts of tribulus terrestris, 1-5 parts of salvia miltiorrhiza bunge, 1-5 parts of mangnolia officinalis, 3-10 parts of radix asparagi, 1-5 parts of holly, 3-10 parts of pseudo-ginseng, 1-5 parts of rhizoma atractylodis and 1-5 parts of dried ginger slices.

Preferably, the Chinese herbal medicine preparation is prepared from 9-15 parts of fructus forsythiae, 5-8 parts of radix angelicae, 5-8 parts of angelica sinensis, 5-8 parts of liquorice, 3-7 parts of lithospermum, 5-8 parts of polygonum multiflorum, 5-8 parts of privet, 5-8 parts of tribulus terrestris, 2-4 parts of salvia miltiorrhiza, 2-4 parts of mangnolia officinalis, 5-8 parts of radix asparagi, 2-4 parts of holly, 5-8 parts of pseudo-ginseng, 2-4 parts of rhizoma atractylodis and 2-4 parts of dried ginger slices.

Preferably, the Chinese herbal medicine preparation is prepared from 9 parts of fructus forsythiae, 6 parts of radix angelicae, 6 parts of angelica sinensis, 6 parts of liquorice, 5 parts of lithospermum, 6 parts of polygonum multiflorum, 6 parts of privet, 6 parts of tribulus terrestris, 3 parts of salvia miltiorrhiza, 3 parts of mangnolia officinalis, 6 parts of radix asparagi, 3 parts of holly, 6 parts of pseudo-ginseng, 3 parts of rhizoma atractylodis and 3 parts of dried ginger slices.

The invention also provides a preparation method of the Chinese herbal medicine preparation for treating leucoderma, which comprises the following steps:

s1, processing the raw material medicaments into fine powder;

s2, accurately weighing and mixing all the medicaments according to the proportion, wherein the weight of each medicament is 900 g;

and S3, packaging each dose independently.

The invention has the following beneficial effects:

1. the invention applies the fructus forsythiae to mainly treat blood diseases: radix Angelicae Dahuricae, radix Angelicae sinensis, and fructus Tribuli for removing blood stasis, promoting health, promoting hematopoiesis, dispelling pathogenic wind, and removing dampness;

2. licorice root, radix Glycyrrhizae tonifies the spleen and qi, clears heat and removes dampness: radix Arnebiae and Saviae Miltiorrhizae radix have effects in invigorating middle warmer and invigorating qi;

3. rhizoma Atractylodis can be used for treating spasm and acne of dead muscle, and cortex Magnolia officinalis, radix asparagi, ilex chinensis and Notoginseng radix can be added for promoting granulation and caring skin;

4. the medicines are used together to have the effects of regulating qi and blood, breaking blood and removing stasis, and nourishing new blood and skin, and can effectively treat leucoderma;

5. the invention selects natural edible plant medicines with homology of medicinal diet as raw materials, and all the components conform to the regulations of the pharmacogenetic law;

6. the comprehensive effects of the traditional Chinese medicines are utilized to treat the vitiligo related to qi and blood malignant change, blood stasis, rheumatism invasion, dead muscle convulsion and skin malnutrition, no chemical sweetener is used, and the traditional Chinese medicines are non-toxic and harmless to a human body;

7. the invention has rich nutrition and convenient drinking of the electuary, and conforms to the regulations of the national food sanitation law;

8. the invention can be drunk by normal people and can strengthen the body.

Detailed Description

The present invention will be described in detail with reference to the following embodiments in order to make the aforementioned objects, features and advantages of the invention more comprehensible. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, but rather should be construed as broadly as the present invention is capable of modification in various respects, all without departing from the spirit and scope of the present invention.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only and do not represent the only embodiments.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

Examples 1, 2 and 3 can be used as drinks, pills and decoctions.

Weighing the raw materials (kilogram) according to the following proportion

①, fructus forsythiae, radix Angelicae Dahuricae, radix Angelicae sinensis, radix Glycyrrhizae, radix Arnebiae, radix Polygoni Multiflori, fructus Ligustri Lucidi, fructus Tribuli, radix Salviae Miltiorrhizae, cortex Magnoliae officinalis, radix asparagi, ilex chinensis, radix Notoginseng, rhizoma Atractylodis, and rhizoma Zingiberis recens by the following preparation and administration methods:

firstly, all the raw materials are processed and crushed into fine powder, and then all the raw materials are accurately mixed according to the proportion

Weighing and mixing, wherein each dose is 720 g: and finally, the powder is brewed with 100 ℃ boiled water and taken as medicinal granules 3 times a day, 20g each time.

The embodiment ② is prepared by weighing the following raw materials in proportion:

fructus forsythiae, radix angelicae, angelica sinensis, liquorice, lithospermum, polygonum multiflorum, ligustrum lucidum ait, tribulus terrestris, salvia miltiorrhiza, mangnolia officinalis, radix asparagi, holly, pseudo-ginseng, rhizoma atractylodis and dried ginger slices, and the preparation and administration modes are as follows:

the raw materials are firstly processed and crushed into fine powder, then all the medicines are accurately weighed and mixed according to the proportion, each medicine is measured to be 800g, and finally the medicine is brewed with 100 ℃ boiled water to be taken as medicinal granules 3 times a day, 20g each time, diseases are treated, and the body is strengthened without diseases.

③, fructus forsythiae, radix Angelicae Dahuricae, radix Angelicae sinensis, radix Glycyrrhizae, radix Arnebiae, radix Polygoni Multiflori, fructus Ligustri Lucidi, fructus Tribuli, radix Salviae Miltiorrhizae, cortex Magnoliae officinalis, Tianmenduo, ilex chinensis, radix Notoginseng, rhizoma Atractylodis, and dried tablet of pedicellus et pericarpium Trapae, and is prepared by the following steps:

firstly, processing and crushing raw materials into fine powder, then accurately weighing and mixing all the medicaments according to the proportion, wherein each medicament is 900 g: finally, the medicine is brewed with 100 ℃ boiled water and taken as medicinal granules 3 times a day, 30g each time, and the medicine mainly treats leucoderma.

In order to show the curative effect of the medicine on leucoderma, 90 cases of systematic clinical observation show that the medicine selects patients with the same medical history, disease conditions, age, sex and original treatment method. Of these, 41 men and 19 women. The age is 18-60. The course of the disease is 1 month to 6 years. The skin damage area is about lcmXlcm-18cmX8 cm. The total number of skin lesions in 90 patients was 106. Patients were randomized into 2 groups of 45 patients each.

Test groups: on the basis of the original treatment, the original medicines are stopped, wherein 15 people take the medicine of the embodiment 1 of the invention, 15 people take the medicine of the embodiment 2 of the invention, and 15 people take the medicine of the embodiment 2 of the invention.

Control group: the medicine is taken continuously according to the conventional or original treatment medicine, and the usage and dosage are matched with the test group. The observation period is 4 months, and the total dosage is 10 doses.

The administration mode is as follows: decocting 400 g of decoction once, taking 25 g of the powder electuary 3 times a day, taking 50 g of the powder electuary 2 times a day in a pill shape according to the size of the pill.

Criteria for judging therapeutic effects

According to the common recognition of the European vitiligo group, the clinical curative effect judges that each person selects a part with the largest skin damage as an object for area calculation, measures the length and the width of the person, calculates the area, takes cm as a unit, respectively observes the development condition of the skin damage in each double-diagnosis, and respectively observes whether the area of the original skin damage is enlarged, whether the edge part of a white spot is clear, whether a pigment island is generated or not and whether isomorphic reaction exists or not.

And (3) healing: white spots on the skin lesion are completely removed, the skin color of the skin lesion is recovered to be normal, and the skin color is not different from that of the surrounding skin.

The effect is shown: the white spot area of the skin lesion part is reduced or reduced, and the area for recovering normal skin color accounts for more than 50 percent of the original skin lesion area:

the method has the following advantages: the white spots on the skin damage part are removed or reduced, and the area for recovering normal skin color accounts for 10 to 50 percent of the original skin damage area;

and (4) invalidation: white spots are unchanged, and the area for recovering normal skin color accounts for less than 10% of the area of skin damage or new skin damage occurs.

The total effective rate (%) - (number of cure cases + number of obvious cases + number of effective cases)/total number of cases X100%

The number of patients in the stationary phase was counted, and the types and number of adverse reactions in each treatment group were recorded. The statistical results are shown in tables 1 and 2:

TABLE 1 area changes of skin lesions before and after treatment of test group and control group

Group of	Number of examples	Before treatment (cm)2)	After treatment (cm)2)
				Test group	45	7.34±5.52	6.12±4.85
Control group	45	7.82±5.19	8.01±5.23

As shown in Table 1, the comparison P before and after treatment in the test group, which is less than 0.05, is statistically significant: the comparison P is more than 0.05 before and after the treatment of the control group, and the statistical significance is avoided.

TABLE 2 clinical effective rate of test group and control group

Group of	Number of examples	Healing number, significant effect number and effective number	Number of invalid	High efficiency
					Test group	45	40	5	88.89％
Control group	45	22	23	48.89％

As shown in Table 2, the effective rate of the experimental group is p < 0.05 compared with the effective rate of the control group, and the statistical significance is provided.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (4)

1. The Chinese herbal medicine preparation for treating leucoderma is characterized by being prepared from 5-20 parts of fructus forsythiae, 3-10 parts of radix angelicae, 3-10 parts of angelica sinensis, 3-10 parts of liquorice, 2-8 parts of lithospermum, 3-10 parts of polygonum multiflorum, 3-10 parts of privet, 3-10 parts of tribulus terrestris, 1-5 parts of salvia miltiorrhiza bunge, 1-5 parts of mangnolia officinalis, 3-10 parts of radix asparagi, 1-5 parts of holly, 3-10 parts of pseudo-ginseng, 1-5 parts of rhizoma atractylodis and 1-5 parts of dried ginger slices.

2. The Chinese herbal medicine preparation for treating vitiligo according to claim 1, which is prepared from 9-15 parts of fructus forsythiae, 5-8 parts of radix angelicae, 5-8 parts of angelica sinensis, 5-8 parts of liquorice, 3-7 parts of lithospermum, 5-8 parts of polygonum multiflorum, 5-8 parts of privet, 5-8 parts of tribulus terrestris, 2-4 parts of salvia miltiorrhiza, 2-4 parts of mangnolia officinalis, 5-8 parts of radix asparagi, 2-4 parts of holly, 5-8 parts of pseudo-ginseng, 2-4 parts of rhizoma atractylodis and 2-4 parts of dried ginger slices.

3. The Chinese herbal medicine for treating vitiligo according to claim 1, which is prepared from 9 parts of forsythia, 6 parts of angelica dahurica, 6 parts of angelica, 6 parts of liquorice, 5 parts of lithospermum, 6 parts of polygonum multiflorum, 6 parts of privet, 6 parts of tribulus terrestris, 3 parts of salvia miltiorrhiza, 3 parts of magnolia officinalis, 6 parts of radix asparagi, 3 parts of holly, 6 parts of pseudo-ginseng, 3 parts of rhizoma atractylodis and 3 parts of dried ginger slices.

4. The preparation method of the Chinese herbal medicine preparation for treating the leucoderma is characterized by comprising the following steps:

s1, processing the raw material medicaments into fine powder;

s2, accurately weighing and mixing all the medicaments according to the proportion, wherein the weight of each medicament is 900 g;

and S3, packaging each dose independently.