CN111053700A - Metformin anti-aging skin care product - Google Patents
Metformin anti-aging skin care product Download PDFInfo
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- CN111053700A CN111053700A CN201811218321.3A CN201811218321A CN111053700A CN 111053700 A CN111053700 A CN 111053700A CN 201811218321 A CN201811218321 A CN 201811218321A CN 111053700 A CN111053700 A CN 111053700A
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention provides an anti-aging metformin skin care product. The skin care product comprises the medicament metformin, other active ingredients, conventional raw auxiliary materials and the like, and can be prepared into skin care products in the forms of paste, emulsion, cream, gel, spray, milk, skin lotion and the like by the technological methods of dissolving, heating, stirring, cooling and the like. The anti-aging drug metformin and other active ingredients in the skin care product can directly act on the surface of the skin or permeate into local or whole body blood circulation through the skin to achieve the effect of transdermal drug delivery, and can be used for skin anti-aging, body anti-aging and treatment of various diseases such as type 2 diabetes, polycystic ovary syndrome, anti-tumor and the like. The invention avoids the damage of the metformin oral drug in the gastrointestinal tract and the possible liver 'first pass' effect and gastrointestinal inactivation; the damage to the liver and the kidney is reduced, the toxic and side effects are reduced, and a new method and a new way are provided for safety, effectiveness and enlargement of the range of users; the anti-skin aging or anti-body aging and the medication method become simpler, more convenient and easier to be accepted.
Description
Belongs to the field of:
the invention belongs to the technical field of cosmetics, and particularly relates to an anti-aging metformin skin care product.
Background art:
aging is an important component of a complex life process and is a natural phenomenon that all organisms must take place. The development of modern life science lays a foundation for revealing the essence of aging and exploring the approach of aging resistance. There are many theories regarding aging, such as genetic control, cell mutation, neuroendocrine, immune, rate of life, reproductive and aging theories, and oxidative stress theories. However, environmental factors, sunlight exposure also have a non-negligible effect on skin aging.
Various anti-aging methods and drugs have been sought in order to delay aging. The delaying of aging by drugs has been one of the research hotspots of people. The traditional anti-aging drugs can be generally divided into two types of traditional Chinese medicines and chemical medicines, and the traditional anti-aging drugs are used in anti-aging skin care products in different ways.
The Chinese medicinal materials include single Chinese medicinal material and compound preparation, and the chemical medicines mainly include antioxidant, antiaging hormone (such as melatonin, thymosin, etc.), nutrient (such as nucleic acid, etc.), monoamine oxidase inhibitor (such as procaine, etc.), immunomodulator (such as transfer factor, etc.), biochemical preparation (salivary gland, etc.), brain function promoter (such as Naokukang, etc.), and other antiaging chemical medicines.
In recent years, numerous studies have been devoted to exploring the characteristics of aging, triggers, signaling pathways, the type of aging, and the various aspects of the cellular aging process for its regulatory mechanisms associated with aging. Through the methods of genetic screening and natural mutation, hundreds of genes and associated signaling pathways have been identified that affect senescence or longevity, including: insulin/IGF-1 signaling pathway (IIS), rapamycin Target (TOR) signaling pathway, adenylate activated protein kinase (AMPK) signaling pathway, heat-shock factors (HSFs), Mitogen Activated Protein Kinases (MAPKs), silencing information regulator 2-like protein (silencing regulator2 homolog 1, sirtuins), and mitochondria-related signaling pathway, which play a role in the process of aging.
More and more researches in recent two years find that the metformin has the effects of resisting aging and prolonging the service life. Metformin is a common medicament for treating diabetes, has longer clinical application history, is safe and reliable, and has low price. The existing research results show that the metformin plays roles in preventing aging and prolonging life in a mode related to caloric restriction, and the molecular mechanism for prolonging life clearly plays roles in resisting aging by activating adenosine monophosphate activated protein kinase (AMPK), inhibiting mammalian target of rapamycin (mTOR) and related molecules downstream of the mammalian target of rapamycin. The research also finds that the metformin can improve the oxidation resistance of cells by inhibiting the intracellular ROS (reactive oxygen species) level and the expression of related matrix metalloproteinase, thereby inhibiting the UVA (ultraviolet ray) induced photoaging effect of skin fibroblasts.
In the aspect of the existing anti-aging skin care products, at present, no anti-aging skin care product which can improve the oxidation resistance of cells and inhibit the photoaging effect of skin fibroblasts induced by UVA by applying metformin to activate adenosine monophosphate activated protein kinase (AMPK), inhibit mammalian target of rapamycin (mTOR) and related molecules at the downstream of the mammalian target of rapamycin (mTOR) to exert the anti-aging effect of mammalian target of rapamycin (mTOR) and inhibit the expression of intracellular ROS level and related matrix metalloproteinases.
Currently, metformin is mainly in an oral dosage form, and after being taken, the metformin can cause uncomfortable reactions due to side effects, such as nausea, vomiting, diarrhea, abdominal pain, abdominal distension, dyspepsia, hypodynamia and the like. If the skin care product is applied on the skin for percutaneous administration, the product can be used for resisting skin aging and body aging. The metformin medicament is absorbed into the blood circulation of a human body through skin, so that the liver first-pass effect can be bypassed, and the medicament is prevented from being damaged in the gastrointestinal tract and the possible liver first-pass effect and gastrointestinal inactivation are avoided; has the advantages of reducing toxic and side effects, convenient administration, good compliance, improving application effect, etc.
In addition, recent studies have also confirmed that metformin is used for the treatment of type 2 diabetes, and its functions have been expanded to the treatment of polycystic ovary syndrome, anti-tumor, treatment of non-alcoholic fatty liver disease, normal human tissue protection, weight loss, and the like.
The invention content is as follows:
the invention aims to provide an anti-aging metformin skin care product. The anti-aging drug metformin and other active ingredients in the skin care product can directly act on the surface of the skin or permeate into the local or systemic blood circulation through the skin, thereby achieving the effect of transdermal administration and anti-aging. Can be used for resisting skin aging and body aging, and can also be used for treating type 2 diabetes, polycystic ovary syndrome, and anti-tumor.
The invention avoids the first-pass effect and gastrointestinal reaction of the metformin oral medicament. The damage of the drug in the gastrointestinal tract and the possible liver 'first pass' effect and gastrointestinal inactivation are avoided; the damage to the liver and the kidney is reduced, the toxic and side effects are reduced, and a new method and a new way are provided for safe medication, application effect improvement and range expansion of the user; the anti-skin aging or anti-body aging and some treatments become simpler, more convenient, easier and more acceptable.
The anti-aging metformin skin care product comprises a medicament metformin, other active ingredients, conventional raw and auxiliary materials and the like, and can be dissolved, heated, stirred, cooled and the like to obtain the skin care products in the forms of paste, emulsion, cream, gel, spray, milk, lotion and the like.
The drug metformin in the metformin anti-aging skin care product can be one form of pharmaceutically acceptable salt thereof, and can also be a metformin derivative. The content of the metformin is as follows by mass percent: 0.1-50%.
The other active ingredients in the metformin anti-aging skin care product comprise: the dosage of the traditional anti-aging drugs, penetration enhancers, humectants and the like is the conventional dosage of cosmetics and pharmacy.
The raw and auxiliary materials in the metformin anti-aging skin care product are conventional raw and auxiliary materials for cosmetics and pharmacy, and the dosage of the raw and auxiliary materials is conventional dosage of cosmetics and pharmacy.
The traditional anti-aging medicaments used in the metformin anti-aging skin care product comprise traditional Chinese medicines and chemical medicaments. The traditional anti-aging drugs can be used in one or more of the prior art.
The traditional Chinese medicine comprises single traditional Chinese medicine and compound preparation:
the main traditional Chinese medicines of a single medicine are as follows: ginseng, astragalus, fleece-flower root, pseudo-ginseng, lucid ganoderma, medlar, acanthopanax, sealwort, glossy privet fruit, south dodder seed, dangshen, malaytea scurfpea fruit, rhodiola rosea, gynostemma pentaphylla, royal jelly, cordyceps sinensis, fragrant solomonseal rhizome, Chinese magnoliavine fruit, common yam rhizome, prepared rehmannia root, south dodder seed, pilose antler, human placenta, honey, gecko, American ginseng and the like. In addition, antiaging mineral medicine (such as Maifanitum and Actinolitum) can be added.
The compound preparation comprises the following components: LIUWEIDIHUANG pill, JINKUISHENQI pill, SHOUWUYANSHOUDAN (YILING essence), GUILINGJI, SIJUNZI decoction, etc.
The chemical drugs mainly comprise antioxidant, anti-aging hormone (such as melatonin, thymosin, etc.), nutrient (such as nucleic acid, etc.), monoamine oxidase inhibitor (such as procaine, etc.), immunomodulator (such as transfer factor, etc.), biochemical preparation (salivary gland, etc.), brain function promoting drug (such as brain rehabilitation, etc.), and other anti-aging chemical drugs.
The antioxidant comprises vitamin E, vitamin C, β -carotene, enzyme antioxidants such as superoxide dismutase (SOD), coenzyme Q, Lipoic Acid (LA), Catalase (CAT), Peroxidase (POD), glutathione peroxidase (GSH-Px), reduced glutathione peptidase (GSH), Glutathione Reductase (GR), tyrosinase-1 β and the like, in addition, the antioxidant also comprises trace elements, and the trace elements related to longevity comprise iron (Fe), selenium (Se), magnesium (Mg), manganese (Mn), copper (Cu), zinc (Zn) and the like.
Anti-aging hormones: melatonin, Human Growth Hormone (HGH), sex hormone, Dehydroepiandrosterone (DHEA), etc., and Melatonin (MT) is widely used.
Nutrients: the anti-aging nutrients comprise proteins, nucleic acids, various amino acids, phospholipids, royal jelly and the like and mixed preparations thereof, and the anti-aging nutrients are various in variety and are mostly researched as the nucleic acids.
Monoamine oxidase inhibitors: the common preparations are procaine, Yikangning, etc.
Immunomodulators: the common preparations include transfer factor, immune thymus factor, interferon inducer, BCG, levamisole, etc.
Brain function promoting drugs: common preparations include clofazic acid ester, amidopyrrone (Naofukang), pyritinol hydrochloride (Naofumei), ergotoxine (Xidezhen), etc.
Other anti-aging drugs such as resveratrol, rapamycin, Astragalus polysaccharides, lutein, lipoic acid, ursolic acid, tea tannin or tannin, α -ketoglutaric acid, etc.
The penetration enhancer comprises: laurocapram (Azone), one or more of propylene glycol, oleic acid, linoleic acid, urea, isopropyl myristate, menthol, Borneolum Syntheticum, etc.
The humectant is as follows: one or more of hyaluronic acid, glycerol, propylene glycol, sorbitol, butanediol, polyethylene glycol, lactic acid, sodium lactate, pyrrolidone carboxylate, etc.
The metformin and other active ingredients in the skin care product can directly act on the surface of the skin or permeate into local or systemic blood circulation through the skin, so that the skin care product achieves the effect of transdermal administration and anti-aging, can be used for skin anti-aging and body anti-aging, and can also be used for treating various diseases such as type 2 diabetes, polycystic ovary syndrome, anti-tumor and the like. The invention avoids the first-pass effect and gastrointestinal tract reaction of the oral metformin medicament, and avoids the destruction of the medicament in the gastrointestinal tract and the possible liver first-pass effect and gastrointestinal tract inactivation; reduces the damage to the liver and the kidney, reduces toxic and side effects, provides a new method and a new way for resisting skin aging or body aging, simultaneously also enables the skin aging or body aging and the medication method to be simpler, more convenient, easier and more acceptable.
Description of the drawings:
FIG. 1 shows the signaling pathway involved in the prolongation of life of metformin, as shown by prior studies.
Results of existing studies show that metformin exerts its anti-aging effects by activating adenylate activated protein kinase (AMPK), inhibiting mammalian target of rapamycin (mTOR) and its downstream related molecules.
The specific implementation mode is as follows:
the following examples further illustrate the invention without limiting the scope thereof.
Example 1:
taking 15g of metformin hydrochloride, 0.3g of hyaluronic acid, 0.5g of carbopol (carbomer), 1.8g of laurocapram, 0.2g of methylparaben and a proper amount of conventional raw and auxiliary materials.
Putting metformin hydrochloride into a proper amount of aqueous solution, and dissolving the metformin hydrochloride for later use; putting hyaluronic acid and carbopol (carbomer) into appropriate amount of water, and swelling; dissolving other agents and conventional raw and auxiliary materials, adding the metformin hydrochloride solution, hyaluronic acid, carbomer solution and conventional raw and auxiliary materials after dissolving, then adding purified water to the total amount of 100g, stirring uniformly, preparing the metformin anti-aging skin care product, and obtaining the product after quality identification is qualified.
Example 2:
taking 28g of metformin hydrochloride, 8g of cetyl alcohol, 3g of dodecyl phosphate, 5g of glycerol, 0.15g of ethylparaben, 2g of laurocapram, 0.2g of hyaluronic acid, 1g of cordyceps sinensis extract and conventional raw and auxiliary materials, and adding distilled water to the total amount of 100 g.
Dissolving metformin hydrochloride, glycerol and hyaluronic acid in distilled water under heating, and stirring; heating and melting sodium dodecyl sulfate, cetyl alcohol, ethylparaben and laurocapram to 85 deg.C, and stirring; slowly adding the water phase into the oil phase, stirring in the same direction until the water phase is condensed to prepare the metformin anti-aging skin care product, and obtaining the product after qualification identification.
Example 3:
taking 5g of metformin hydrochloride, 2g of oleic acid, 0.8g of laurocapram, 1.5g of oil monostearate, 0.Sg of stearic acid, 1g of squalane, 1g of simethicone, 1g of polyglycerol fatty acid ester, 2g of glycerol, 2g of propylene glycol, 0.5g of hyaluronic acid, 2g of alginic acid, 0.1g of methyl paraben, 0.05g of ethyl paraben, a proper amount of vitamin E, a proper amount of vitamin C and conventional raw and auxiliary materials, and adding deionized water to the total amount of 100 g.
Mixing the oil phase, heating and stirring uniformly, adding a surfactant, and mixing the water phase, heating and stirring uniformly; adding the water phase into the oil phase, stirring and emulsifying for 10-20 minutes at 1000 revolutions per minute, cooling, adding metformin hydrochloride and a high-temperature-resistant drug into the mixture, stirring at a low speed, uniformly mixing, stirring at 1000 revolutions per minute for fully emulsifying, preparing the metformin anti-aging skin care product, and obtaining the product after qualification identification.
Example 4:
30g of metformin hydrochloride, 3.0g of stearic acid, 2.8g of cetyl alcohol, 1g of polyglycerol fatty acid ester, 10g of propylene glycol, 3.Sg of aloe extract, 5.0g of hydrolyzed protein liquid and conventional raw and auxiliary materials are taken, and deionized water is added to the total amount of 100 g.
Mixing the oil phase, heating and stirring uniformly, and mixing the water phase, heating and stirring uniformly; adding the water phase into the oil phase, stirring and emulsifying for 10-20 minutes at 1000 r/min, adding metformin hydrochloride into the mixture, stirring at low speed, uniformly mixing, stirring at 1000 r/min for fully emulsifying to obtain the metformin anti-aging skin care product, and identifying to be qualified.
Claims (9)
1. The anti-aging metformin skin care product is characterized by comprising the following components in parts by weight: the skin care product consists of a medicament metformin, other active ingredients, conventional raw and auxiliary materials and the like, and can be prepared by the process methods of dissolving, heating, stirring, cooling and the like, wherein the process methods comprise the following steps: skin care products in the form of ointment, emulsion, cream, gel, spray, milk, lotion, etc.
2. The anti-aging metformin skin care product according to claim 1, wherein: the drug metformin can be in a form of pharmaceutically acceptable salt thereof, and also can be a metformin derivative, wherein the metformin content is calculated by mass percent: 0.1-50%.
3. The anti-aging metformin skin care product according to claim 1, wherein: the other active ingredients are as follows: the dosage of the traditional anti-aging drugs, penetration enhancers, humectants and the like is the conventional dosage of cosmetics and pharmacy.
4. The anti-aging metformin skin care product according to claim 3, wherein: among the other active ingredients, the conventional anti-aging drugs are classified into: the traditional Chinese medicine and the chemical medicine can be used as one or more of the traditional anti-aging medicines.
5. The anti-aging metformin skin care product according to claim 4, wherein: the traditional Chinese medicine in the traditional anti-aging medicine comprises a single traditional Chinese medicine and a compound preparation;
the main traditional Chinese medicines of a single medicine are as follows: ginseng, astragalus, fleece-flower root, pseudo-ginseng, lucid ganoderma, medlar, acanthopanax, sealwort, glossy privet fruit, south dodder seed, dangshen, malaytea scurfpea fruit, rhodiola rosea, gynostemma pentaphylla, royal jelly, cordyceps sinensis, fragrant solomonseal rhizome, Chinese magnoliavine fruit, common yam rhizome, prepared rehmannia root, south dodder seed, pilose antler, human placenta, honey, gecko, American ginseng and the like, and anti-aging mineral medicines and the like;
the compound preparation comprises the following components: LIUWEIDIHUANG pill, JINKUISHENQI pill, SHOUWUYANSHOUDAN (YILING essence), GUILINGJI, SIJUNZI decoction, etc.
6. The anti-aging metformin skin care product according to claim 4, wherein: the chemical drugs in the prior anti-aging drugs in the other active ingredients mainly comprise antioxidants, anti-aging hormones, nutrients, monoamine oxidase inhibitors, immunomodulators, biochemical preparations, brain function promoting drugs and other anti-aging chemical drugs;
wherein the antioxidant comprises vitamin E, vitamin C, β -carotene, etc., enzyme antioxidant such as superoxide dismutase (SOD), coenzyme Q, thioctic acid (LA), Catalase (CAT), Peroxidase (POD), glutathione peroxidase (GSH-Px), reduced glutathione peptidase (GSH), Glutathione Reductase (GR), tyrosine phospholipase-1 β, etc., and trace elements such as iron (Fe), selenium (Se), magnesium (Mg), manganese (Mn), copper (Cu), zinc (Zn), etc., wherein the trace element preparation can be compound preparation;
wherein the anti-aging hormones include: melatonin, Human Growth Hormone (HGH), sex hormone, Dehydroepiandrosterone (DHEA), and the like;
the nutrients include: protein, nucleic acid, various amino acids, phospholipid, royal jelly, etc., and mixed preparations thereof;
wherein the monoamine oxidase inhibitor comprises: procaine, Yikangning, etc.;
wherein the immunomodulator comprises: transfer factor, immune thymic factor, interferon inducer, BCG vaccine, levamisole, etc.;
the brain function promoting medicine comprises: clofibrate, amidopyridone (Naofukang), pyritinol hydrochloride (Naofukang), ergotoxine hydrochloride (Xidezhen), etc.;
wherein the other anti-aging drugs include resveratrol, rapamycin, Astragalus polysaccharides, lutein, lipoic acid, ursolic acid, tea tannin or tannin, α -ketoglutaric acid, etc.
7. The anti-aging metformin skin care product according to claim 3, wherein: the penetration enhancer in the other active ingredients is: one or more of laurocapram (Azone), propylene glycol, oleic acid, linoleic acid, urea, isopropyl myristate, menthol, Borneolum Syntheticum, etc.
8. The anti-aging metformin skin care product according to claim 3, wherein: the humectant in the other active components is as follows: one or more of hyaluronic acid, glycerol, propylene glycol, sorbitol, butanediol, polyethylene glycol, lactic acid, sodium lactate, pyrrolidone carboxylate, etc.
9. The anti-aging metformin skin care product according to claim 1, wherein: the skin care product in the forms of ointment, emulsion, cream, gel, spray, milk, lotion and the like can be used for resisting skin aging and body aging, and also can be used for treating various diseases such as type 2 diabetes, polycystic ovary syndrome, anti-tumor and the like.
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| CN201811218321.3A CN111053700A (en) | 2018-10-17 | 2018-10-17 | Metformin anti-aging skin care product |
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| CN201811218321.3A CN111053700A (en) | 2018-10-17 | 2018-10-17 | Metformin anti-aging skin care product |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111840127A (en) * | 2020-08-13 | 2020-10-30 | 亘元(天津)生物医药科技有限公司 | Free radical scavenger with anti-aging and sugar-resistant functions and preparation method thereof |
| CN114931549A (en) * | 2022-02-17 | 2022-08-23 | 同济大学 | Application of metformin injection in preparation of anti-aging product for improving cognitive level |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2320735A1 (en) * | 1975-08-12 | 1977-03-11 | Dabis Georges | Percutaneous biguanide compsns. - esp. contg. metformin hydrochloride or pamoate, for treatment of cellulitis |
| WO2005011566A2 (en) * | 2003-07-29 | 2005-02-10 | Pharmamens | Cosmetic use of a biguanide derivative as an anti-ageing active substance for the skin |
-
2018
- 2018-10-17 CN CN201811218321.3A patent/CN111053700A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2320735A1 (en) * | 1975-08-12 | 1977-03-11 | Dabis Georges | Percutaneous biguanide compsns. - esp. contg. metformin hydrochloride or pamoate, for treatment of cellulitis |
| WO2005011566A2 (en) * | 2003-07-29 | 2005-02-10 | Pharmamens | Cosmetic use of a biguanide derivative as an anti-ageing active substance for the skin |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111840127A (en) * | 2020-08-13 | 2020-10-30 | 亘元(天津)生物医药科技有限公司 | Free radical scavenger with anti-aging and sugar-resistant functions and preparation method thereof |
| CN111840127B (en) * | 2020-08-13 | 2023-08-11 | 亘元(天津)生物医药科技有限公司 | Free radical scavenger with anti-aging and sugar-blocking effects and preparation method thereof |
| CN114931549A (en) * | 2022-02-17 | 2022-08-23 | 同济大学 | Application of metformin injection in preparation of anti-aging product for improving cognitive level |
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