CN110975146A - Wireless energy supply in-vivo active electrical stimulation device for treating gastroesophageal reflux disease - Google Patents
Wireless energy supply in-vivo active electrical stimulation device for treating gastroesophageal reflux disease Download PDFInfo
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- CN110975146A CN110975146A CN201911395431.1A CN201911395431A CN110975146A CN 110975146 A CN110975146 A CN 110975146A CN 201911395431 A CN201911395431 A CN 201911395431A CN 110975146 A CN110975146 A CN 110975146A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37205—Microstimulators, e.g. implantable through a cannula
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
- A61N1/37235—Aspects of the external programmer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/378—Electrical supply
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Abstract
The invention relates to the technical field of rehabilitation medical devices, in particular to a wireless energy supply in-vivo active electrical stimulation device for treating gastroesophageal reflux disease, which comprises an in-vitro wireless controller, a wireless energy transmission module and an implanted functional electrical stimulator, wherein the external wireless controller is in communication connection with the implanted functional electrical stimulator, the implanted functional electrical stimulator adopts an active design, a microcontroller in vivo controls a stimulation circuit to generate stimulation pulses, an energy receiving circuit and the implanted electrical stimulator are integrated and then packaged by using a biocompatible material, the energy receiving circuit and the implanted electrical stimulator are implanted into the abdomen of a patient, the stimulation pulses generated by the electrical stimulator are transmitted to a stimulation electrode through an electrode lead, so that implanted electrical stimulation is carried out on lower esophageal sphincter, the purpose of treating the gastroesophageal reflux disease is achieved, and the problems caused by the complex system structure and the battery power supply of devices in the prior art for treating the gastroesophageal, the invention has good prospect in the aspect of treating gastroesophageal reflux disease.
Description
Technical Field
The invention belongs to the technical field of rehabilitation medical devices, and particularly relates to a wireless energy supply in-vivo active electrical stimulation device for treating gastroesophageal reflux disease.
Background
Gastroesophageal Reflux Disease (GERD) refers to a condition in which the contents of the stomach Reflux into the esophagus, causing symptoms and/or complications of discomfort. Worldwide, there are approximately 2.5 million GERD patients. GERD severely impacts the quality of life of the patient, creating a heavy economic and social burden. With the annual incidence of GERD increasing, the social medical burden is getting heavier and heavier, and the rational diagnosis and treatment of GERD have become hot spots of worldwide concern and research.
It is currently believed that GERD occurs primarily in connection with dysfunction of the Lower Esophageal Sphincter (LES). The human LES is a specially thickened ring muscle located at the gastroesophageal junction, and the axial width of the human LES is about 2-3 cm. LES is composed of noose fibers (Sling fibers) running obliquely on the greater curvature of the stomach, and hook fibers (Clasp fibers) in the hemiorbicular shape of the lesser curvature of the stomach. The LES and the diaphragm foot are kept in a continuous contraction state under the regulation of nerves and body fluid, so that a high pressure belt (usually 15-30 mmHg) is formed at the gastroesophageal junction to form a physiological anti-reflux barrier of a human body, prevent the reflux of gastric contents and ensure the relaxation during swallowing. However, when LES presents hypobaric pressure and fails to close properly, the contents of the stomach (including stomach acid) reflux into the esophagus causing discomfort symptoms, resulting in the onset of GERD.
The current treatment means for GERD mainly include drug treatment and surgical treatment. The medicine treatment has the problem of treating both symptoms and root causes, the cure rate of the medicine is not more than 60 percent in 4 weeks, and the relapse rate is more than 70 percent after the medicine is stopped. The patient compliance is poor, the symptoms are easy to relapse after the medicine is stopped, and the patient has to take the medicine for a long time. This not only increases the economic burden of the patient, but also brings inconvenience to the life of the patient. The surgery treatment has large trauma, and complications such as dysphagia, digestive tract perforation and the like can occur after the surgery.
The urgent need at home and abroad is to find a treatment method which can reduce the wound and obtain good curative effect, thus leading the implanted electronic system which is emerging in recent years to become a research hotspot. The implanted electronic system is a product of the intersection of microelectronic technology and clinical medicine, is a new hot spot in the current medical development, and has wide application prospect.
As an engineering approach of great interest, LES electrical stimulation therapy offers a new approach to the treatment of refractory GERD. The basic principle of the LES electrical stimulation therapy method is to enhance the LES pressure by electrically stimulating LES at low pressure, thereby restoring the function of LES to resist reflux. The advantages of LES electrical stimulation therapy are as follows:
1) LES electric stimulation treatment is to fundamentally enhance LES pressure and recover the function of LES anti-reflux;
2) the electrical stimulation does not affect the relaxation of LES, and has no side effects such as dysphagia, abdominal distension and diarrhea;
3) the stimulation device can be implanted in a minimally invasive way, the operation is simple, and the anatomical structures of the esophagus and the stomach are reserved;
4) GERD patients treated by LES electrical stimulation no longer rely on therapeutic drugs, avoiding the cost and safety issues of long-term use of drugs.
Endostim, Netherlands, developed an implantable LES stimulator for treating GERD that provided a new approach to treating refractory GERD. The implantation of the whole stimulation system can be completed within 30-40 minutes through minimally invasive laparoscopic surgery, and the anatomical structures of the stomach and the esophagus are not changed in the implantation process. The Endostim system can be individually designed in a wireless programming mode according to individual requirements, and can set stimulation parameters according to the disease history and the life style of a patient. In addition, the Endostim system also has a lying position detection function, and can automatically treat when a patient lies down, so that the problem of treating GERD at night or on the back is solved. The EndoStim system includes an implantable pulse generator, an implantable bipolar lead, and an extracorporeal programmer. The implanted electrical stimulation device increases the LES pressure by applying functional electrical stimulation to the LES, thereby achieving the purpose of treating GERD. Long-term clinical trial results have demonstrated that the EndoStim system is able to significantly improve GERD symptoms without the side effects associated with implantation or stimulation, nor any safety issues associated with LES electrical stimulation. The device has passed CE certification and is approved to enter the European market. The EndoStim system, however, also has some inherent drawbacks: the in-vivo stimulation circuit has a complex structure, and the reliability of the system is reduced to a certain extent; the stimulation system is powered by an in-vivo battery, and when the electrical stimulation intensity is increased, the service life of the battery is correspondingly reduced. In addition, the stimulator needs to be imported from abroad, is expensive and is difficult to bear by common patients.
Disclosure of Invention
In view of the above situation, in order to overcome the defects of the prior art, the invention provides a wireless energy supply in-vivo active electrical stimulation device for treating gastroesophageal reflux disease, which solves the problems that the implantable system for treating gastroesophageal reflux disease in the prior art is complex in structure and cannot supply energy externally, so that once the service life of a battery is exhausted, the battery needs to be replaced again in an operation.
The wireless energy supply in-vivo active type electrical stimulation device for treating gastroesophageal reflux disease comprises an in-vitro wireless controller, a wireless energy transmission module and an implanted functional electrical stimulator, wherein the external wireless controller is in communication connection with the implanted functional electrical stimulator;
the external wireless controller comprises an upper computer, an external microprocessor, an external wireless transceiver, an external power management circuit and an external rechargeable lithium battery, wherein the external wireless transceiver and the upper computer are in communication connection with the external microprocessor, and are used for transmitting a control signal to the internal functional electric stimulator by the external controller in a wireless mode after the external wireless transceiver receives the control signal transmitted by the upper computer through the external microprocessor, the external power management circuit is in communication connection with the external microprocessor, and the external power management circuit is electrically connected with the external rechargeable lithium battery;
the wireless energy transmission module comprises an external energy transmitting circuit, a transmitting coil, a receiving coil, an internal energy receiving circuit and an internal rechargeable lithium battery, wherein the external energy transmitting circuit is in communication connection with an external microprocessor, the transmitting circuit is electrically connected with the transmitting coil and is used for transmitting energy to the inside of a body through the resonant transmitting coil after converting direct-current voltage of an external power supply into alternating-current voltage, the receiving coil is electrically connected with the internal energy receiving circuit, the internal energy receiving circuit is electrically connected with the internal rechargeable lithium battery, the internal energy receiving circuit comprises a rectifying circuit, a filtering circuit and a power supply management circuit and is used for converting the alternating-current voltage obtained by coupling on the receiving coil into direct-current voltage, and the internal rechargeable lithium battery is electrically connected with the implanted functional electric stimulator;
the implantable functional electric stimulator comprises an in-vivo microprocessor, an in-vivo wireless transceiver, an in-vivo power management circuit and a stimulation circuit, wherein the in-vivo microprocessor is in communication connection with the in-vivo wireless transceiver, the in-vivo microprocessor is electrically connected with the in-vivo power management circuit, the in-vivo microprocessor is electrically connected with the stimulation circuit, the stimulation circuit is electrically connected with a bipolar electrode, the in-vivo wireless transceiver transmits a received control signal to the in-vivo microprocessor, and the in-vivo microprocessor is used for controlling the stimulation circuit to generate corresponding stimulation pulses and transmitting the stimulation pulses to the bipolar electrode.
Preferably, the external energy transmitting circuit comprises a 4MHz active crystal oscillator, a class E power amplifier and a linear regulator, the 4MHz active crystal oscillator is electrically connected with the class E power amplifier, and the class E power amplifier is electrically connected with the linear regulator.
Preferably, the in-vivo energy receiving circuit includes a capacitor filter bridge rectifier circuit and a buck-boost charge pump voltage stabilizer, and the capacitor filter bridge rectifier circuit is electrically connected to the buck-boost charge pump voltage stabilizer.
The invention has the advantages that on the basis of realizing the function of the implanted functional electric stimulator, the wireless energy transmission function is added, thereby solving the problems that the traditional implanted system can not supply energy externally, has limited battery service life, needs to replace the battery again in an operation, and the like;
the device adopts three modules of an external wireless controller, a wireless energy transmission module and an implanted functional electric stimulator, and has the characteristics of simple structure, stable function, small volume, low cost, long service life and the like;
due to the arrangement of the upper computer, a doctor can effectively adjust the stimulation parameters of the implanted electric stimulator in time in a wireless programming mode, so that individualized treatment is carried out on a patient, feedback information can be received in time, and the implanted electric stimulator is monitored.
Drawings
FIG. 1 is a block diagram of a wireless powered in vivo active electrical stimulation device system for the treatment of gastroesophageal reflux disease, according to the present invention;
FIG. 2 is a block diagram of a wireless controller in vitro of a wireless powered in vivo active electrical stimulation device for treating gastroesophageal reflux disease according to the present invention;
FIG. 3 is a block diagram of a wireless energy transmission module of a wireless energy-supplying in-vivo active electrical stimulation device for treating gastroesophageal reflux disease according to the present invention;
fig. 4 is a structural block diagram of the implanted LES electric stimulator of the wireless energy supply in-vivo active type electric stimulation device for treating gastroesophageal reflux disease.
The device comprises an external wireless controller (1), an upper computer (11), an external microprocessor (12), an external wireless transceiver (13), an external power management circuit (14), an external rechargeable lithium battery (15), a lithium battery charging circuit (16), a USB interface (17), a USB-to-serial port circuit (18), a Debug interface (19), a wireless energy transmission module (2), an external energy transmitting circuit (21), a transmitting coil (22), a receiving coil (23), an internal energy receiving circuit (24), an internal rechargeable lithium battery (25), a 4MHz active crystal oscillator (211), an E-type power amplifier (212), a linear voltage stabilizer (213), a capacitive filter bridge rectifier circuit (241), a voltage reduction-boosting type charge pump voltage stabilizer (242), an implanted functional electric stimulator (3), an internal wireless transceiver (31), an internal microprocessor (32), The stimulation device comprises an internal power management circuit (33), a stimulation circuit (34), a DAC circuit (341) and a voltage-controlled constant-current stimulation circuit (342).
Detailed Description
The following detailed description of the embodiments of the present invention is provided in conjunction with the accompanying drawings.
The first embodiment is as follows: according to the attached drawings of the specification, the wireless energy supply in-vivo active type electrical stimulation device for treating gastroesophageal reflux disease comprises an in-vitro wireless controller 1, a wireless energy transmission module 2 and an implanted functional electrical stimulator 3, wherein the in-vitro wireless controller 1 is in communication connection with the implanted functional electrical stimulator 3;
the in-vitro wireless controller 1 comprises an upper computer 11, an in-vitro microprocessor 12, an in-vitro wireless transceiver 13, an in-vitro power supply management circuit 14 and an in-vitro rechargeable lithium battery 15, wherein the in-vitro wireless transceiver 13 and the upper computer 11 are both in communication connection with the in-vitro microprocessor 12, and are used for transmitting a control signal to the in-vivo functional electric stimulator 3 by the in-vitro controller 1 in a wireless mode after the in-vitro wireless transceiver 13 receives the control signal transmitted by the upper computer 11 through the in-vitro microprocessor 12, the in-vitro power supply management circuit 14 is in communication connection with the in-vitro microprocessor 12, and the in-vitro power supply management circuit 14 is electrically connected with the in-;
the wireless energy transmission module 2 comprises an external energy transmitting circuit 21, a transmitting coil 22, a receiving coil 23, an internal energy receiving circuit 24 and an internal rechargeable lithium battery 25, the external energy transmitting circuit 21 is in communication connection with the external microprocessor 12, the transmitting circuit 21 is electrically connected with the transmitting coil 22, for converting the dc voltage of the external power source into ac voltage and transmitting energy into the body through the resonant transmitting coil 22, the receiving coil 23 is electrically connected to an in-vivo energy receiving circuit 24, the in-vivo energy receiving circuit 24 is electrically connected to an in-vivo rechargeable lithium battery 25, the in-vivo energy receiving circuit 24 includes rectifying, filtering and power management circuits, the in-vivo rechargeable lithium battery 25 is electrically connected with the implanted functional electrical stimulator 3 and is used for converting alternating voltage obtained by coupling the receiving coil 23 into direct voltage;
the implantable functional electrical stimulator 3 comprises an in-vivo microprocessor 32, an in-vivo wireless transceiver 31, an in-vivo power management circuit 33 and a stimulation circuit 34, wherein the in-vivo microprocessor 32 is in radio frequency communication connection with the in-vivo wireless transceiver 31, the in-vivo microprocessor 32 is electrically connected with the in-vivo power management circuit 33, the in-vivo microprocessor 32 is electrically connected with the stimulation circuit 34, the stimulation circuit 34 is electrically connected with a bipolar electrode, the in-vivo wireless transceiver 31 transmits a received control signal to the in-vivo microprocessor 32, and the in-vivo microprocessor 32 is used for controlling the stimulation circuit 34 to generate corresponding stimulation pulses and transmitting the stimulation pulses to the bipolar electrode.
The in vitro wireless controller 1 comprises a CC2541 module consisting of an in vitro microprocessor and an in vitro wireless transceiver, an in vitro power management circuit 14, an in vitro rechargeable lithium battery 15, a lithium battery charging circuit 16, a USB interface 17, a USB-to-serial port circuit 18 and a Debug interface 19. The in-vitro wireless controller 1 uses an on-chip system integrating an in-vitro microprocessor 12 and an in-vitro wireless transceiver 13, and can communicate with the upper computer 11. After receiving the control signal transmitted from the upper computer 11, the external controller 1 transmits the control signal to the internal LES electrical stimulator 3 in a wireless manner, thereby controlling the stimulation parameters and the working state of the LES electrical stimulator 3. The internal LES electric stimulator 3 feeds back the internal information to the external wireless controller 1 in time, so that doctors and patients can monitor the state of the internal LES electric stimulator 3 through the upper computer 11. In order to make the external part of the whole wireless energy-supplying LES electrical stimulation system including the external energy transmitting circuit 21 and the external wireless controller 1 more portable and easy to use, the external energy transmitting circuit 21 and the external wireless controller 1 are integrated. The integrated in-vitro wireless controller 1 has the functions of energy emission and wireless control. The functional brief description of each component part in the extracorporeal wireless controller 1 is as follows:
the CC2541 module 12: as the core of the in vitro wireless controller 1, the in vivo implanted function electric stimulator 3 is wirelessly controlled based on the low power consumption Bluetooth technology;
external power management circuit 14: converting the power supply voltage of the external rechargeable lithium battery 15 or the USB port 17 into the working voltage required by the CC2541 module 12, the energy transmitting circuit 21 and the USB-to-serial port circuit 18;
external rechargeable lithium battery 15: power supply for the extracorporeal wireless controller 1;
lithium battery charging circuit 16: when the USB interface 17 of the in-vitro wireless controller 1 is plugged into a power supply, the lithium battery 15 is charged and managed;
the USB interface 17: the interface is used as an interface for the communication between the external wireless controller 1 and the upper computer 11 and also used as an interface for charging the lithium battery;
the USB-to-serial port circuit 18: when the in-vitro wireless controller 1 is connected with the upper computer 11 by using a USB data line, converting the USB communication mode into serial communication;
debug interface 19: for debugging and updating the in vitro wireless controller 1;
external energy transmitting circuit 21: used for wireless energy transmission and provides energy for the implanted functional electric stimulator 3 in the body.
The wireless energy transmission module 2 is designed based on the electromagnetic coupling principle and comprises an external energy transmitting circuit 21, a transmitting coil 22, a receiving coil 23, an internal energy receiving circuit 24 and an internal rechargeable lithium battery 25. The external energy transmitting circuit 21 converts a direct current voltage of an external power supply into an alternating current voltage and transmits energy into the body through the resonant transmitting coil 22. The internal energy receiving circuit 24 includes a rectifying circuit, a filtering circuit, and a power management circuit, and converts the ac voltage coupled to the receiving coil 23 into a dc voltage. The circuit can directly supply power to the implanted functional electric stimulator 3 through the in-vivo power management circuit 33, and can also charge the in-vivo rechargeable lithium battery 25 through the charging circuit, and the in-vivo rechargeable lithium battery 25 supplies power to the implanted functional electric stimulator 3.
The external energy transmitting circuit 21 consists of a 4MHz active crystal oscillator 211, a class E power amplifier 212 and a linear voltage regulator 213. The 4MHz active crystal oscillator 211 is electrically connected with the E-type power amplifier 212, and the E-type power amplifier 213 is electrically connected with the linear voltage regulator 213. Its main function is to convert the dc voltage supplied by the external rechargeable lithium battery 15 into a large amplitude ac voltage and to load it to the transmitting coil 22, which resonates at the operating frequency, to transmit energy into the body. The class E power amplifier 212 can theoretically achieve 100% conversion efficiency and the circuit implementation is simple. Therefore, the class E power amplifier 212 is employed as a power transmitting circuit in the extracorporeal energy transmitting circuit 21. Since the transistors in the class-E power amplifier 212 need to operate in the switching state, the 4MHz active crystal 211 is used in the design of the present invention to provide the switching signal. The linear regulator 213 in the external energy transmitting circuit 21 provides a stable power input to the class-E power amplifier 212.
The in-vivo energy receiving circuit 24 is mainly composed of a capacitor filter bridge rectifier circuit 241 and a buck-boost charge pump voltage regulator 242, and the capacitor filter bridge rectifier circuit 241 is electrically connected to the buck-boost charge pump voltage regulator 242. The capacitor filter bridge rectifier circuit 241 can convert the ac voltage coupled by the receiving coil 23 into a dc voltage, and the buck-boost charge pump regulator 242 can regulate the dc voltage obtained by the rectifying and filtering. The rectified, filtered and regulated power output can be used to directly power the stimulator through the in vivo power management circuit 33 in the implanted functional electrical stimulator 3, or to charge the in vivo rechargeable lithium battery 25 and be powered by the in vivo rechargeable lithium battery 25. The step-down and step-up charge pump voltage regulator 242 used in the design of the present invention has the characteristic of wide voltage input, so as to ensure that the wireless energy transmission module 2 can normally work in an nonideal or even severe working environment, and stably and reliably provide enough energy for the implanted functional electrical stimulator 3.
The implanted functional electrical stimulator 3 comprises an energy receiving circuit 24, an on-chip system integrating an in-vivo microprocessor 32 and an in-vivo wireless transceiver 31, an in-vivo power management circuit 33, a DAC circuit 341 and a voltage-controlled constant-current stimulation circuit 342. After receiving the energy transmitted by the external energy transmitting circuit 21, the energy receiving circuit 24 may directly supply power to the internal microprocessor 32, the DAC circuit 341, and the voltage-controlled constant-current stimulation circuit 342 of the implantable functional electrical stimulator 3 through the internal power management circuit 33, or may charge the internal rechargeable lithium battery 25, and the internal rechargeable lithium battery 25 supplies power to subsequent circuits. After receiving the control signal transmitted from the outside of the body through the in-vivo wireless transceiver 31, the in-vivo microprocessor 32 controls the DAC circuit 341 to generate the voltage stimulation pulse with controllable amplitude through the serial peripheral interface. The voltage stimulation pulse with controllable amplitude generated by the DAC circuit 341 can control the subsequent voltage-controlled constant-current stimulation circuit 342 to generate a current stimulation pulse with a corresponding magnitude. The in-vivo energy receiving circuit 24 and the implanted functional electric stimulator 3 are integrated and then encapsulated by using a biocompatible material and implanted into the abdomen subcutaneous of the patient. An electrode lead connected with the implanted functional electric stimulator 3 penetrates through the abdominal wall from the subcutaneous part to enter the abdominal cavity, and a stimulation pulse generated by the implanted functional electric stimulator 3 is transmitted to a stimulation electrode implanted in the LES, so that the lower esophageal sphincter is electrically stimulated, the pressure of the lower esophageal sphincter is enhanced, and the purpose of treating gastroesophageal reflux disease is achieved.
The wireless energy transmission function is added on the basis of realizing the function of the implanted functional electric stimulator, so that the problems that the traditional implanted system cannot supply energy externally, has limited battery service life, needs to replace batteries again in an operation and the like are solved; the device adopts three modules of an external wireless controller, a wireless energy transmission module and an implanted functional electric stimulator, and has the characteristics of simple structure, stable function, small volume, low cost, long service life and the like; through the setting of host computer, the doctor can in time adjust the stimulation parameter of implanted electric stimulator effectively through wireless programming's mode to carry out individuation treatment to the patient, can also in time receive feedback information, accomplish the control to implanted electric stimulator.
The present invention has been described in detail with reference to the specific embodiments and examples, but these are not intended to limit the present invention. Many variations and modifications may be made by one of ordinary skill in the art without departing from the principles of the present invention, which should also be considered as within the scope of the present invention.
Claims (3)
1. A wireless energy supply in-vivo active type electrical stimulation device for treating gastroesophageal reflux disease is characterized by comprising an external wireless controller (1), a wireless energy transmission module (2) and an implanted functional electrical stimulator (3), wherein the external wireless controller (1) is in wireless communication connection with the implanted functional electrical stimulator (3);
the in-vitro wireless controller (1) comprises an upper computer (11), an in-vitro microprocessor (12), an in-vitro wireless transceiver (13), an in-vitro power supply management circuit (14) and an in-vitro rechargeable lithium battery (15), wherein the in-vitro wireless transceiver (13) and the upper computer (11) are in communication connection with the in-vitro microprocessor (12), the in-vitro wireless transceiver (13) is used for transmitting a control signal to the in-vivo functional electric stimulator (3) in a wireless mode after receiving the control signal transmitted by the upper computer (11) through the in-vitro microprocessor (12), the in-vitro power supply management circuit (14) is in communication connection with the in-vitro microprocessor (12), and the in-vitro power supply management circuit (14) is electrically connected with the in-vitro rechargeable lithium battery (15);
the wireless energy transmission module (2) comprises an external energy transmitting circuit (21), a transmitting coil (22), a receiving coil (23), an internal energy receiving circuit (24) and an internal rechargeable lithium battery (25), wherein the external energy transmitting circuit (21) is in communication connection with an external microprocessor (12), the transmitting circuit (21) is electrically connected with the transmitting coil (22) and is used for converting the direct-current voltage of an external power supply into radio-frequency voltage and then transmitting energy into the body through the resonant transmitting coil (22), the receiving coil (23) is electrically connected with the internal energy receiving circuit (24), the internal energy receiving circuit (24) is electrically connected with the internal rechargeable lithium battery (25), the internal energy receiving circuit (24) comprises a rectifying circuit, a filtering circuit and a power supply management circuit and is used for converting the radio-frequency voltage obtained by coupling on the receiving coil (23) into the direct-current voltage, the in-vivo rechargeable lithium battery (25) is electrically connected with the implanted functional electrical stimulator (3);
the implantable functional electrical stimulator (3) comprises an in-vivo microprocessor (32), an in-vivo wireless transceiver (31), an in-vivo power management circuit (33) and a stimulation circuit (34), wherein the in-vivo microprocessor (32) is in communication connection with the in-vivo wireless transceiver (31), the in-vivo microprocessor (32) is electrically connected with the in-vivo power management circuit (33), the in-vivo microprocessor (32) is electrically connected with the stimulation circuit (34), the stimulation circuit (34) is electrically connected with a bipolar electrode, the in-vivo wireless transceiver (31) transmits a received control signal to the in-vivo microprocessor (32), and the in-vivo microprocessor (32) is used for controlling the stimulation circuit (34) to generate a corresponding stimulation pulse and transmitting the stimulation pulse to the bipolar electrode.
2. The wireless-powered in vivo active electrical stimulation device for the treatment of gastroesophageal reflux disease according to claim 1, wherein the external energy transmitting circuit (21) comprises a 4MHz active crystal oscillator (211), a class E power amplifier (212) and a linear regulator (213), the 4MHz active crystal oscillator (211) and the class E power amplifier (212) are electrically connected, and the class E power amplifier (212) and the linear regulator (213) are electrically connected.
3. The wirelessly powered in-vivo active electrical stimulation apparatus for the treatment of gastroesophageal reflux disease according to claim 1, wherein the in-vivo energy receiving circuit (24) comprises a capacitive filter bridge rectifier circuit (241) and a buck-boost charge pump regulator (242), the capacitive filter bridge rectifier circuit (241) and the buck-boost charge pump regulator (242) being electrically connected.
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| CN201911395431.1A CN110975146A (en) | 2019-12-30 | 2019-12-30 | Wireless energy supply in-vivo active electrical stimulation device for treating gastroesophageal reflux disease |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112138280A (en) * | 2020-09-19 | 2020-12-29 | 西安交通大学医学院第一附属医院 | Therapeutic instrument for resisting gastroesophageal reflux disease with infinite electrical stimulation function |
| WO2024023719A1 (en) * | 2022-07-27 | 2024-02-01 | Multi-Scale Medical Robotics Center Limited | Wirelessly powered electrical stimulation systems and related methods |
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2019
- 2019-12-30 CN CN201911395431.1A patent/CN110975146A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112138280A (en) * | 2020-09-19 | 2020-12-29 | 西安交通大学医学院第一附属医院 | Therapeutic instrument for resisting gastroesophageal reflux disease with infinite electrical stimulation function |
| WO2024023719A1 (en) * | 2022-07-27 | 2024-02-01 | Multi-Scale Medical Robotics Center Limited | Wirelessly powered electrical stimulation systems and related methods |
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