CN110960351A - Tinnitus treatment music generation method, medium, equipment and tinnitus treatment instrument - Google Patents

Tinnitus treatment music generation method, medium, equipment and tinnitus treatment instrument Download PDF

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CN110960351A
CN110960351A CN201911236005.3A CN201911236005A CN110960351A CN 110960351 A CN110960351 A CN 110960351A CN 201911236005 A CN201911236005 A CN 201911236005A CN 110960351 A CN110960351 A CN 110960351A
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tinnitus
music
frequency
treatment
modulation
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CN110960351B (en
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李华伟
唐冬梅
孙珊
蓝军
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Chongqing Zhiting Digital Medical Technology Co ltd
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Eye and ENT Hospital of Fudan University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F11/00Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M21/02Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0027Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense

Abstract

The invention provides a tinnitus treatment music generation method, medium, equipment and a tinnitus treatment instrument. The tinnitus treatment music generation method comprises the following steps: acquiring tinnitus frequency; calculating a modulation frequency range according to the tinnitus frequency; and performing enhanced modulation on a music file within the modulation frequency range to obtain the tinnitus treatment music. The tinnitus treatment music generating method can inhibit nerve activity of tinnitus region overexcitation, thereby relieving or eliminating tinnitus.

Description

Tinnitus treatment music generation method, medium, equipment and tinnitus treatment instrument
Technical Field
The invention belongs to the field of voice or sound processing, relates to a music generation method, and particularly relates to a tinnitus treatment music generation method, a medium, equipment and a tinnitus treatment instrument.
Background
The normal human ear can hear sound, needs the external sound source or the sound of the body, realizes sound and electricity transduction through the sound collection of the external ear, sound transmission and amplification of the middle ear, and the generated nerve impulse is transmitted to all levels of auditory centers, and finally causes auditory sense in the cerebral cortex through complex information processing. Thus, the perception of sound by the human ear is dependent on hair cells, with different frequencies of sound corresponding to different hair cells and neurons. When hair cells corresponding to a certain frequency are damaged, the signals of the auditory center are deprived and the hearing loss of the sound of the frequency is caused; at this point, the auditory nervous system remodels such that the neuron to which the frequency sound corresponds and its neighboring neurons are hyperactive or explosive in synchrony with firing, which produces tinnitus.
Tinnitus has a disease rate of 10-15% in adults all over the world, and seriously harms the health and life quality of the public. Tinnitus often causes mental disorders such as dysphoria, insomnia, anxiety, depression, etc., and serious persons even pessimistic collapse to cause suicide tendency, thus seriously harming the health and life quality of the public. The current treatment for tinnitus mainly comprises tinnitus masking and habitual treatment. The tinnitus masking adopts white noise to achieve complete masking of the tinnitus, but the white noise or narrow-band noise is dull and hard to hear, and many patients cannot insist on the white noise or narrow-band noise. The habitual treatment is to select natural sounds such as wind sound, running water sound and bird call according to the preference of a patient, and try to replace ear sound with a sound, so that the patient adapts or is accustomed to tinnitus to improve the emotion of the patient, but the habitual treatment does not weaken or disappear the tinnitus. Therefore, it is difficult to effectively treat tinnitus with the existing tinnitus treatment methods.
Disclosure of Invention
In view of the above-mentioned disadvantages of the prior art, it is an object of the present invention to provide a tinnitus treatment music generating method, medium, device and tinnitus treatment apparatus for solving the problem that the prior tinnitus treatment method is difficult to effectively treat tinnitus.
To achieve the above and other related objects, the present invention provides a tinnitus treatment music generating method comprising: acquiring tinnitus frequency; calculating a modulation frequency range according to the tinnitus frequency; and performing enhanced modulation on a music file within the modulation frequency range to obtain the tinnitus treatment music.
In an embodiment of the present invention, a method for calculating a modulation frequency range according to the tinnitus frequency includes: determining a 1 octave upper limit end point and a 1 octave lower limit end point which take the tinnitus frequency as a central frequency; determining a 1/N octave upper end point and a 1/N octave lower end point which take the 1 octave upper end point as a central frequency to obtain a first frequency band; wherein N is a positive integer; and determining a 1/N octave upper end point and a 1/N octave lower end point which take the 1 octave lower end point as a central frequency to obtain a second frequency band.
In an embodiment of the present invention, the method for implementing enhanced modulation on a music file in the modulation frequency range to obtain music for treating tinnitus includes: and performing enhancement modulation on the music file in the first frequency band and the second frequency band respectively to obtain the tinnitus treatment music.
In an embodiment of the present invention, the method for implementing enhanced modulation on a music file in the modulation frequency range to obtain music for treating tinnitus includes: and enhancing the frequency components of the music file in the modulation frequency band range to obtain the tinnitus treatment music.
In an embodiment of the present invention, the method for implementing enhanced modulation on a music file in the modulation frequency range to obtain music for treating tinnitus includes: determining a tinnitus position; the tinnitus position comprises a left ear and/or a right ear; and performing enhancement modulation on the left sound channel and/or the right sound channel of the music file according to the tinnitus position to obtain the tinnitus treatment music.
In an embodiment of the present invention, the method for generating music for treating tinnitus further includes: acquiring tinnitus loudness; setting the volume of the tinnitus treatment music according to the tinnitus loudness matching.
In an embodiment of the invention, the music file is a pure music file.
The present invention also provides a computer-readable storage medium having stored thereon a computer program; the computer program when called executes the tinnitus treatment music generating method of the present invention.
The present invention also provides an electronic device, including: a memory storing a computer program; the processor is in communication connection with the memory and executes the tinnitus treatment music generation method when the computer program is called; a display, communicatively coupled to the processor and the memory, for displaying a GUI interactive interface associated with the tinnitus treatment music generation method.
The present invention also provides a tinnitus treatment apparatus, comprising: the electronic equipment is used for generating tinnitus treatment music; and the earphone or the sound is connected with the electronic equipment and is used for playing the tinnitus treatment music.
As mentioned above, the tinnitus treatment music generation method, medium, equipment and therapeutic apparatus of the invention have the following beneficial effects:
the tinnitus treatment music generation method can select a specific modulation frequency range according to the tinnitus frequency of a patient and perform enhanced modulation on a music file in the modulation frequency range to obtain tinnitus treatment music:
the tinnitus treatment music is more pleasing to the ear and more acceptable to the patient than the noise used in the tinnitus masking therapy;
the tinnitus treatment music can regulate the emotion of a patient by utilizing the emotion regulating function of the music, so that the negative emotions of the patient, such as dysphoria, anxiety and the like, are fully relieved;
the tinnitus treatment music only has energy enhancement in the modulation frequency range on two sides of tinnitus frequency, can target the abnormal overactive adjacent brain area of discharge caused by hearing deprivation of a tinnitus patient, and can relieve the abnormal 'excitation' of the tinnitus brain area, so that the tinnitus loudness of adjacent undamaged neuron tuning characteristics is reduced after hearing deprivation, and even the tinnitus disappears.
Drawings
Fig. 1 is a flowchart illustrating a method of generating music for treating tinnitus according to an embodiment of the present invention.
Fig. 2 is a flowchart illustrating a step S2 of the music generating method for tinnitus treatment according to an embodiment of the present invention.
Fig. 3 is a graph showing the energy of tinnitus treatment music obtained by the method for generating tinnitus treatment music according to the present invention.
Fig. 4 is a flowchart illustrating a method of generating music for treating tinnitus according to an embodiment of the present invention.
Fig. 5A shows the change of visual analog scale of tinnitus loudness obtained in one embodiment of the present invention.
Fig. 5B shows the change in tinnitus loudness scale obtained in an embodiment of the present invention.
Fig. 5C shows the change in tinnitus disability status scale obtained in one embodiment of the invention.
Fig. 5D shows the tinnitus related sleep state change obtained in an embodiment of the present invention.
Fig. 6 is a schematic structural diagram of an electronic device according to an embodiment of the invention.
Description of the element reference numerals
500 electronic device
510 memory
520 processor
530 display
S1-S3
S21-S23
S41-S45
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention. It is to be noted that the features in the following embodiments and examples may be combined with each other without conflict.
It should be noted that the drawings provided in the following embodiments are only for illustrating the basic idea of the present invention, and the drawings only show the components related to the present invention rather than being drawn according to the number, shape and size of the components in actual implementation, and the type, number and proportion of the components in actual implementation may be changed arbitrarily, and the layout of the components may be more complicated.
The human ear's perception of sound depends on hair cells, with different frequencies of sound corresponding to different hair cells and neurons. When hair cells corresponding to a certain frequency are damaged, the signal deprivation of an auditory center can be caused, and the hearing loss of sound of the frequency is caused; at this point, the auditory nervous system is remodeled to hyperactive or explosive synchrony firing the neuron corresponding to the frequency sound and its neighboring neurons. Tinnitus may be produced by hyperactive or explosive synchronous firing of the adjacent neurons. The area where the hyperactive or explosive synchronous firing neighbor neurons are located is called the tinnitus area. The sound audio segment corresponding to the neuron in the tinnitus region is called tinnitus frequency segment.
Tinnitus is subjective auditory perception when no corresponding sound source or electric stimulation exists outside, and long-term tinnitus can bring psychological disorders such as dysphoria, insomnia, anxiety, depression and the like to patients. The current treatment for tinnitus mainly comprises tinnitus masking and habitual treatment. White noise or narrow-band noise is mostly adopted for tinnitus masking so as to achieve complete masking on the tinnitus. However, white noise or narrow-band noise is relatively uninteresting and difficult for many patients to persist. The conventional therapy is to select natural sounds such as wind sound, running water sound, bird call and the like according to the preference of a patient, try to replace tinnitus sound with a sound, reduce arousal of the tinnitus and improve the mood of the patient, but the conventional therapy does not weaken or eliminate the tinnitus.
In order to solve the above problems, the present invention provides a tinnitus treatment music generating method, including: acquiring tinnitus frequency; calculating a modulation frequency range according to the tinnitus frequency; and performing enhanced modulation on a music file within the modulation frequency range to obtain the tinnitus treatment music. The tinnitus treatment music generation method can generate pleasant music for patients, so that the problem that many patients are difficult to insist due to the fact that noise is dull and hard to hear in the tinnitus masking therapy is solved. The tinnitus treatment music generation method can select a modulation frequency range according to tinnitus frequency, enhance and modulate music files in the frequency range to obtain tinnitus treatment music, and effectively relieve or even eliminate tinnitus by inhibiting over-excited nerve activity in a tinnitus area.
Referring to fig. 1, in an embodiment of the present invention, the method for generating music for treating tinnitus includes:
and S1, acquiring tinnitus frequency. The tinnitus frequency refers to the frequency of the tinnitus sound and can be obtained in various ways.
According to the pathogenesis of tinnitus, the tinnitus is mainly generated from local auditory central signal deprivation caused by the loss of the perception ability of human ears on sound of a specific frequency band, and the tinnitus sound is generated by the hyperactive or explosive synchronous discharge of adjacent neurons of corresponding neurons of the specific frequency band. Therefore, the tinnitus sound frequency mostly coincides with the hearing loss band or adopts the adjacent frequency of the hearing loss band.
And S2, calculating a modulation frequency range according to the tinnitus frequency. The modulation frequency band range refers to one or more adjacent frequency bands of tinnitus frequencies.
And S3, performing enhanced modulation on a music file in the modulation frequency range to obtain the tinnitus treatment music. The enhancement modulation may be implemented by commonly used audio processing software.
For a frequency band (for example, 20HZ to 20kHZ), the frequency band is divided into a plurality of frequency bands, and if the upper limit frequency of each frequency band is twice higher than the lower limit frequency, that is, the ratio of the frequencies is 2, each frequency band thus divided is called 1 octave, which is abbreviated as octave. An octave band can be subdivided into N frequency bands of equal proportional width, i.e. 1/N octaves.
Referring to fig. 2, in an embodiment of the present invention, a method for calculating a modulation frequency range according to the tinnitus frequency includes:
and S21, determining a 1 octave upper limit end point and a 1 octave lower limit end point which take the tinnitus frequency as a central frequency.
S22, determining a 1/N octave upper end point and a 1/N octave lower end point which take the 1 octave upper end point as a center frequency to obtain a first frequency band; wherein N is a positive number; preferably, N is an integer.
And S23, determining a 1/N octave upper end point and a 1/N octave lower end point which take the 1 octave lower end point as a center frequency to obtain a second frequency band.
The above steps will be described in detail as follows:
and S21, determining a 1 octave upper limit end point and a 1 octave lower limit end point which take the tinnitus frequency as a central frequency.
If the tinnitus frequency is Ft, the upper limit end points of the 1 octave are Fl and Fu, and the definition of the 1 octave can be known as follows: fu is 2Fl, and Fu × Fl is Ft2Obtained by solving
Figure BDA0002304899460000051
S22, determining a 1/N octave upper end point and a 1/N octave lower end point which take the 1 octave upper end point as a center frequency to obtain a first frequency band; wherein N is a positive integer.
According to the definition of 1/N octave, the following can be obtained: the 1/N octave upper end point Fuu with the 1 octave upper end point as the center frequency is (2)1/N)1/2X Fu; the lower end point Ful of 1/N octave taking the upper end point of 1 octave as the center frequency is (2)1/N)-1/2X Fu. The first frequency band range is [ Ful, Fuu ]]。
And S23, determining a 1/N octave upper end point and a 1/N octave lower end point which take the 1 octave lower end point as a center frequency to obtain a second frequency band.
According to the definition of 1/N octave, the following can be obtained: taking the lower limit end of the 1 octave as a central frequency, and setting the upper end Flu of the 1/N octave as (2)1/N)1/2X Fl; the lower end point Fll of 1/N octave taking the lower end point of 1 octave as the center frequency is (2)1/N)-1/2XFl. The first frequency band range is [ Fll, Flu]。
In this embodiment, 1/N octaves corresponding to the upper end point and the lower end point of the 1 octave using the tinnitus frequency as the center frequency are respectively selected as the first frequency band and the second frequency band, so that the first frequency band and the second frequency band can be regarded as adjacent frequency bands of the tinnitus frequency band. The tinnitus frequency band refers to a sound frequency band corresponding to neurons in a tinnitus area, and the tinnitus area refers to an area where the neurons which are extremely active or explosive and synchronously discharge are located.
In this embodiment, the first frequency band and the second frequency band correspond to adjacent brain regions of the tinnitus region, respectively, thereby enabling the tinnitus treatment music to target the adjacent brain regions of the tinnitus patient's abnormally overactive firing neurons due to hearing deprivation.
In an embodiment of the present invention, if N is 3, the first frequency band range is about [1.26 xft, 1.59 xft ], and the second frequency band range is about [0.63 xft, 0.79 xft ]. In this embodiment, the first frequency band is 1/3 octaves with the 1 octave upper limit end point as the center frequency; the second frequency band is 1/3 frequency bins with the lower limit end point of the 1 octave as the center frequency. Considering the sound resolution of human ears, 1/3 octaves are selected as the first frequency band and the second frequency band, so that the adjacent frequency bands of the tinnitus frequency band can be accurately determined.
In an embodiment of the present invention, the method for implementing enhanced modulation on a music file in the modulation frequency range to obtain music for treating tinnitus includes: and performing enhancement modulation on the music file in the first frequency band and the second frequency band respectively to obtain the tinnitus treatment music.
In this embodiment, the first frequency band and the second frequency band may be regarded as adjacent frequency bands of the tinnitus frequency band. And the neurons corresponding to the sounds of the first frequency band and the second frequency band are adjacent neurons of the neurons in the tinnitus region. According to the lateral inhibition principle, the music file is subjected to enhancement modulation in the first frequency band and the second frequency band respectively to stimulate adjacent neurons of the neurons in the tinnitus region, so that the excitation degree of the neurons in the tinnitus region is inhibited, the neurons in the tinnitus region are separated from a hyperactive or explosive synchronous discharge state, and the purpose of reducing or even eliminating tinnitus is achieved.
Lateral inhibition refers to an inhibitory effect that occurs between adjacent neurons, that is, when a neuron is stimulated to excite it, and then the excitation of the adjacent neuron stimulates it, the inhibition of the former is caused by the excitation of the latter. Therefore, in this embodiment, stimulation of neurons in the vicinity of the tinnitus region can inhibit neurons in the tinnitus region.
The embodiment can implement personalized treatment according to tinnitus sites on the basis of tinnitus frequency detection, thereby relieving abnormal excitation of tinnitus brain areas, reducing tinnitus loudness caused by adoption of adjacent undamaged upper neuron tuning features after hearing deprivation, and further realizing reduction and even elimination of tinnitus.
In an embodiment of the present invention, the method for implementing enhanced modulation on a music file in the modulation frequency range to obtain music for treating tinnitus includes: and enhancing the frequency components of the music file in the modulation frequency band range to obtain the tinnitus treatment music.
The music file contains a plurality of frequency components, and amplification of the frequency components may be achieved by an equalizer or an amplifier. In this embodiment, the frequency components of the music file located in the modulation frequency range are enhanced, and the frequency components located outside the modulation frequency range are not processed. Preferably, the frequency components in the modulation frequency range are enhanced by 5-10 dB. It is further preferred that the frequency components within the modulation band are enhanced by 10 dB.
Please refer to fig. 3, which shows the relationship between the music energy and the frequency for tinnitus treatment. Where a represents the energy value before the music file is not enhancement modulated. In the first and second frequency bands, the energy of the tinnitus treatment music is enhanced to a +10dB, thereby enabling the tinnitus treatment music to effectively stimulate adjacent neurons of the tinnitus region.
In an embodiment of the present invention, the method for implementing enhanced modulation on a music file in the modulation frequency range to obtain music for treating tinnitus includes: determining a tinnitus position; the tinnitus position comprises a left ear and/or a right ear; and performing enhancement modulation on the left sound channel and/or the right sound channel of the music file according to the tinnitus position to obtain the tinnitus treatment music.
In this embodiment, the left channel of the music file is enhancement modulated while the left ear is tinnitus. And performing enhancement modulation on a right sound track of the music file when the right ear is tinnitus. The patient can select the earphones with the left and right sound channels separated to listen to the tinnitus treatment music.
In an embodiment of the present invention, the method for generating music for treating tinnitus further includes: acquiring tinnitus loudness; setting the volume of the tinnitus treatment music according to the tinnitus loudness matching. Preferably, the volume of the tinnitus treatment music is adjusted to be equal to or slightly greater than the loudness of the tinnitus. The volume setting of the tinnitus treatment music can inhibit tinnitus of a patient and cannot damage hearing of the patient.
In an embodiment of the invention, the music file is a pure music file. Because the frequency and the intensity of the pure music are changed at any time, the frequency and the intensity of the enhanced and modulated tinnitus treatment music are also changed constantly and surround the adjacent area of the tinnitus frequency all the time, so the tinnitus treatment music can be used for riding the tinnitus center to coordinate and reset the music.
In addition, a soothing, graceful pure music file may be selected as the music file. By utilizing the constantly changing rhythm and the pleasant function of the music, the tinnitus treatment music can simultaneously relieve the negative emotions of dysphoria, anxiety and the like of the tinnitus patients.
In an embodiment of the present invention, the tinnitus treatment music format may be wav, wma, mp3, etc.
Referring to fig. 4, in an embodiment of the present invention, the method for generating music for treating tinnitus includes:
s41, acquiring tinnitus frequency by a three-point forced selection method;
s42, determining a 1 octave upper limit end point and a 1 octave lower limit end point which take the tinnitus frequency as a central frequency;
s43, determining a 1/3 octave upper end point and a 1/3 octave lower end point which take the 1 octave upper end point as a center frequency to obtain a first frequency band;
s44, determining a 1/3 octave upper end point and a 1/3 octave lower end point which take the 1 octave lower end point as a center frequency to obtain a second frequency band;
s45, acquiring music files and performing energy enhancement on the music files in the first frequency band and the second frequency band to obtain tinnitus treatment music; preferably, the magnitude of the energy boost is 10 dB.
Specifically, the implementation method for obtaining the tinnitus frequency of the patient by adopting the three-point forced selection method in the step S41 includes:
playing 3 pure tones with 1 octave intervals, wherein the frequencies of the pure tones are Fa, Fb and Fc respectively, so that a patient can select a pure tone closest to the tinnitus of the patient; if the patient selects the pure tone with the frequency Fa, then playing three pure tones with the frequencies Fa/4, Fb/4 and Fc/4 respectively, and enabling the patient to select one pure tone closest to the tinnitus of the patient; if the patient selects the pure tone with the frequency of Fc, then playing three pure tones with the frequencies of 4Fa, 4Fb and 4 Fc; if the patient selects a pure tone with frequency Fb, the patient's tinnitus frequency is determined to be in the range of Fa or higher and Fc or lower. The above process is repeated until the tinnitus frequency of the patient is accurate 1/3 octaves, and the 1/3 octaves center frequency is the tinnitus frequency of the patient.
In one embodiment of the present invention, tinnitus treatment music generated by the tinnitus treatment music generation method of the present invention is used to treat tinnitus patients in the experimental group and the tinnitus patients in the control group are treated with the unmodulated enhanced music file. T1 indicates treatment of tinnitus patients for 3 months, T0 indicates treatment initiation, and T1-T0 indicates the scale score value 3 months after treatment minus the scale score value before treatment initiation. The ordinates of fig. 5A-5D show mean ± standard deviation, with "×" indicating significant differences in the statistical results, with "×" corresponding to p <0.05, "×" corresponding to p <0.01, and "×" -corresponding to p < 0.001. Wherein P represents a P value, and a smaller value thereof indicates a more significant difference.
Please refer to fig. 5A, which shows the change of the visual analog scale of tinnitus loudness obtained in this embodiment. The tinnitus loudness visual simulation scale is used for reflecting the subjective evaluation score condition of tinnitus loudness, the range is 0-10, 0 means no ear sound, and 10 means that the ear sound is extremely large and difficult to bear. A larger scale number indicates a greater loudness of the tinnitus for the subjective assessment, and a smaller scale number indicates a lesser loudness of the tinnitus for the subjective assessment. The change condition of the tinnitus loudness visual simulation scale is obtained by subtracting the scale value before treatment from the scale value after 3 months of treatment, and the smaller the change value is, the better the treatment effect on tinnitus is.
Please refer to fig. 5B, which shows the change of the tinnitus loudness scale obtained in this embodiment. The tinnitus loudness scale is used to reflect an objective assessment score for tinnitus loudness, obtained, for example, by a tinnitus loudness matching test. A larger scale number indicates a greater tinnitus loudness and a smaller scale number indicates a subjectively assessed tinnitus loudness. The change condition of the tinnitus loudness scale is obtained by subtracting the tinnitus loudness scale value before treatment from the tinnitus loudness scale value after 3 months of treatment, and the smaller the change condition value is, the better the treatment effect on the tinnitus is.
Please refer to fig. 5C, which shows the change of the tinnitus disability status scale obtained in this example. The tinnitus disability condition scale is used for evaluating influence conditions of tinnitus on emotion, psychology, work and life and the like of a patient. A larger scale value indicates a greater adverse effect of tinnitus on the mood, mind, work and life of the patient, and a smaller scale value indicates a lesser adverse effect of tinnitus on the mood, mind, work and life of the patient. The change condition of the tinnitus disability condition scale is obtained by subtracting the value of the tinnitus disability condition scale when the tinnitus disability condition scale is not treated from the value of the tinnitus disability condition scale after 3 months of treatment, and the smaller the value of the change condition is, the better the treatment effect on the tinnitus is.
Please refer to fig. 5D, which shows the change of sleep state related to tinnitus (asi sleep scale) obtained in the present embodiment. The asi sleep scale is used to assess the effect of tinnitus on sleep in a patient. A larger scale value indicates a greater effect of tinnitus on the patient's sleep, and a smaller scale value indicates a lesser adverse effect of tinnitus on the patient's sleep. The tinnitus related sleep state change condition is obtained by subtracting the value of the No-treatment Ash sleep scale from the value of the Ash sleep scale after 3 months of treatment, and the smaller the value of the change condition is, the better the tinnitus treatment effect is.
In this embodiment, it can be known from comparison of the corresponding scales of the patients in the control group and the patients in the experimental group that the tinnitus treatment music generated by the tinnitus treatment music generation method of the present invention can effectively relieve the tinnitus condition of the patients, reduce the loudness of tinnitus, and simultaneously improve the negative mood and sleep condition of the tinnitus patients.
The present invention also provides a computer-readable storage medium having stored thereon a computer program characterized in that: the computer program when called executes the tinnitus treatment music generating method of the present invention.
Referring to fig. 6, the present invention further provides an electronic device 600, wherein the electronic device 600 includes: a memory 610 storing a computer program; a processor 620, communicatively coupled to the memory 610, for executing the tinnitus treatment music generating method of the present invention when the computer program is invoked; a display 630, communicatively coupled to the processor and the memory, for displaying a GUI interactive interface associated with the tinnitus treatment music generation method.
The invention also provides a tinnitus treatment instrument, which comprises the electronic equipment, and is used for generating tinnitus treatment music; and the earphone or the sound is connected with the electronic equipment and is used for playing the tinnitus treatment music.
The protection scope of the tinnitus music generating method of the present invention is not limited to the execution sequence of the steps listed in this embodiment, and all the steps added or removed and the steps replaced according to the prior art made by the principle of the present invention are included in the protection scope of the present invention.
The existing tinnitus treatment method is common in traditional tinnitus masking and habitual treatment, the sound stimulation form is single, the two treatment methods only aim at temporary masking or habit of tinnitus symptoms, and treatment is not carried out aiming at tinnitus pathogenesis, so that long-term effect is difficult to obtain. The masking effect lasts only a few seconds and the mere physical masking therapy may even cause potential hearing damage to the tinnitus patient.
The tinnitus treatment music generation method has the following advantages:
according to the tinnitus treatment music generation method, a specific modulation frequency range is selected and music files are subjected to enhanced modulation in the modulation frequency range, so that the tinnitus treatment music can target adjacent brain areas with abnormal overactive discharge caused by hearing deprivation of tinnitus patients, and the tinnitus is relieved or even eliminated through a side inhibition principle;
the tinnitus treatment music generation method can generate different tinnitus treatment music according to the tinnitus frequency of different patients, so that personalized treatment of the patients is realized;
the tinnitus treatment music generation method can select pure soothing music as the music file, and the obtained tinnitus treatment music has the effect of treating tinnitus and can relieve the emotion of a patient;
the tinnitus treatment music generation method can fix the volume of the tinnitus treatment music to be equal to or slightly larger than the tinnitus loudness, and cannot damage the hearing of a patient on the premise of fully inhibiting the tinnitus sound.
In conclusion, the present invention effectively overcomes various disadvantages of the prior art and has high industrial utilization value.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.

Claims (10)

1. A tinnitus treatment music generating method, wherein the tinnitus treatment music generating method comprises:
acquiring tinnitus frequency;
calculating a modulation frequency range according to the tinnitus frequency;
and performing enhanced modulation on a music file within the modulation frequency range to obtain the tinnitus treatment music.
2. The method of generating tinnitus therapy music according to claim 1 wherein the step of calculating a range of modulation bands from the tinnitus frequency comprises:
determining a 1 octave upper limit end point and a 1 octave lower limit end point which take the tinnitus frequency as a central frequency;
determining a 1/N octave upper end point and a 1/N octave lower end point which take the 1 octave upper end point as a central frequency to obtain a first frequency band; wherein N is a positive integer;
and determining a 1/N octave upper end point and a 1/N octave lower end point which take the 1 octave lower end point as a central frequency to obtain a second frequency band.
3. The method of generating music for treating tinnitus as claimed in claim 2 wherein the step of obtaining music for treating tinnitus includes the steps of:
and performing enhancement modulation on the music file in the first frequency band and the second frequency band respectively to obtain the tinnitus treatment music.
4. The method of generating music for treating tinnitus as claimed in claim 1 wherein the step of obtaining music for treating tinnitus comprises the step of performing enhanced modulation on a music file within the modulation frequency band range:
and enhancing the frequency components of the music file in the modulation frequency band range to obtain the tinnitus treatment music.
5. The method of generating music for treating tinnitus as claimed in claim 1 wherein the step of obtaining music for treating tinnitus comprises the step of performing enhanced modulation on a music file within the modulation frequency band range:
determining a tinnitus position; the tinnitus position comprises a left ear and/or a right ear;
and performing enhancement modulation on the left sound channel and/or the right sound channel of the music file according to the tinnitus position to obtain the tinnitus treatment music.
6. The tinnitus treatment music generating method of claim 1 further comprising:
acquiring tinnitus loudness;
setting the volume of the tinnitus treatment music according to the tinnitus loudness matching.
7. The method of generating music for treating tinnitus as claimed in claim 1 wherein: the music files are pure music files.
8. A computer-readable storage medium having stored thereon a computer program, characterized in that: the computer program when invoked performs a tinnitus treatment music generation method of any one of claims 1-7.
9. An electronic device, characterized in that the electronic device comprises:
a memory storing a computer program;
a processor, communicatively coupled to the memory, that when invoked performs the tinnitus therapy music generating method of any of claims 1-7;
a display, communicatively coupled to the processor and the memory, for displaying a GUI interactive interface associated with the tinnitus treatment music generation method.
10. A tinnitus treatment instrument, characterized in that it comprises:
the electronic device of claim 9, for generating tinnitus therapy music;
and the earphone or the sound is connected with the electronic equipment and is used for playing the tinnitus treatment music.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113349764A (en) * 2021-05-24 2021-09-07 无锡清耳话声科技有限公司 Tinnitus detection and sound treatment equipment
CN114913873A (en) * 2022-05-30 2022-08-16 四川大学 Tinnitus rehabilitation music synthesis method and system

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021611A (en) * 1976-04-23 1977-05-03 Alfred Ange Auguste Tomatis Electronic hearing apparatus
CN1349727A (en) * 1999-03-17 2002-05-15 柯廷技术大学 Tinnitus rehabilitation device and method
CN104783808A (en) * 2015-04-09 2015-07-22 复旦大学附属眼耳鼻喉科医院 Tinnitus detecting method and tinnitus therapeutic apparatus
CN204636380U (en) * 2015-04-09 2015-09-16 复旦大学附属眼耳鼻喉科医院 A kind of tinnitus therapeutic apparatus
CN105999509A (en) * 2016-05-06 2016-10-12 苏州桑德欧声听觉技术有限公司 A tinnitus treating music generating method and a tinnitus treating system
CN107041810A (en) * 2017-03-30 2017-08-15 中山大学孙逸仙纪念医院 A kind of tinnitus treatment system and therapeutic equipment stimulated based on pure tone
CN107041809A (en) * 2017-03-30 2017-08-15 中山大学孙逸仙纪念医院 A kind of tinnitus treatment system and therapeutic equipment
CN108720993A (en) * 2017-04-24 2018-11-02 无锡矽太益耳听力科技有限公司 A kind of tin of damage treats the generation method of sound and listens damage treatment system

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021611A (en) * 1976-04-23 1977-05-03 Alfred Ange Auguste Tomatis Electronic hearing apparatus
CN1349727A (en) * 1999-03-17 2002-05-15 柯廷技术大学 Tinnitus rehabilitation device and method
CN1606970A (en) * 1999-03-17 2005-04-20 柯廷技术大学 Tinnitus rehabilitation method
CN104783808A (en) * 2015-04-09 2015-07-22 复旦大学附属眼耳鼻喉科医院 Tinnitus detecting method and tinnitus therapeutic apparatus
CN204636380U (en) * 2015-04-09 2015-09-16 复旦大学附属眼耳鼻喉科医院 A kind of tinnitus therapeutic apparatus
CN105999509A (en) * 2016-05-06 2016-10-12 苏州桑德欧声听觉技术有限公司 A tinnitus treating music generating method and a tinnitus treating system
CN107041810A (en) * 2017-03-30 2017-08-15 中山大学孙逸仙纪念医院 A kind of tinnitus treatment system and therapeutic equipment stimulated based on pure tone
CN107041809A (en) * 2017-03-30 2017-08-15 中山大学孙逸仙纪念医院 A kind of tinnitus treatment system and therapeutic equipment
CN108720993A (en) * 2017-04-24 2018-11-02 无锡矽太益耳听力科技有限公司 A kind of tin of damage treats the generation method of sound and listens damage treatment system

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113349764A (en) * 2021-05-24 2021-09-07 无锡清耳话声科技有限公司 Tinnitus detection and sound treatment equipment
CN114913873A (en) * 2022-05-30 2022-08-16 四川大学 Tinnitus rehabilitation music synthesis method and system
CN114913873B (en) * 2022-05-30 2023-09-01 四川大学 Tinnitus rehabilitation music synthesis method and system

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