CN110946972A - Application of pearl ganoderma preparation in preparing medicine for resisting fatigue and hypoimmunity - Google Patents
Application of pearl ganoderma preparation in preparing medicine for resisting fatigue and hypoimmunity Download PDFInfo
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Abstract
The invention discloses an application of a pearl ganoderma preparation in preparing a medicine for resisting fatigue and treating low immunity, wherein the pearl ganoderma preparation comprises the following components in parts by weight: 35-75 parts of ganoderma lucidum extract, 30-60 parts of glossy privet fruit, 60-150 parts of turmeric root-tuber, 60-150 parts of nutgrass galingale rhizome, 35-75 parts of yerbadetajo herb, 60-150 parts of dried orange peel and 15-35 parts of pearl layer powder; the ratio of the components in the pearl ganoderma preparation reduces the mutual antagonism effect of the medicines to the maximum extent, so that the traditional Chinese medicines are mutually matched and act together according to the compatibility relationship, the aerobic metabolism is increased, the fatigue elimination and physical strength recovery are accelerated, the immune system can be helped to be stimulated, the normal operation of in-vivo microcirculation is promoted, the individual immunocompetence is enhanced, the medicine property is mild, the effect is obvious, no side effect is caused, and a new medicine choice is provided for the treatment of fatigue resistance and low immunity.
Description
Technical Field
The invention relates to the technical field of new application of Chinese patent medicines, in particular to application of a pearl ganoderma preparation in preparing a medicine for resisting fatigue and low immunity.
Background
Fatigue is a comprehensive physiological process involving a plurality of physiological and biochemical factors, is a normal physiological phenomenon which inevitably occurs when the human brain or physical activity reaches a certain stage, marks the temporary reduction of the original working capacity of the body, and possibly is a precursor for the body to develop into an injured state, and if the body is not considered, the body is damaged; the rapid development of science and technology enables people to increase working pressure and quicken life pace, and products such as computers, mobile phones, televisions and the like become necessary articles for people in work and life. After the work that is nervous in one day is finished, most people still turn over electronic products such as mobile phones and flat plates for a long time, so that people still surround the electromagnetic radiation in amateur life and are in the electromagnetic radiation environment for a long time, fatigue phenomena can be caused to occur to people more easily, fatigue symptoms such as headache, dizziness, nausea, tinnitus, eye dryness and the like are felt to different degrees, and the people are reminded that the organism is required to recover the function through rest, so that further damage to the body is avoided.
The immunity refers to the ability of an organism to resist invasion of foreign viruses and maintain the stability of the environment in the organism, when the immune function is disordered or low, the ability of the organism to resist infection is reduced, the ability of identifying and eliminating self-aged tissue cells is reduced, the ability of killing and eliminating abnormal mutant cells in the organism is reduced, the disease resistance and the self-healing ability of the human body are reduced, the modern society has the advantages of quickened life rhythm and increased competitive pressure, the organism can be in a overdraft state due to intense work and study every day, if the organism cannot be in a timely rest and adjustment, the organism can be restrained from long-term accumulation, if the organism is in the state for a long time, the immunity of the organism is reduced, and finally the sub-health state of the organism is caused.
Modern medical science proves that the medicine for improving the immunity of the organism, preventing diseases, slowing down aging, improving memory, enhancing physical strength and improving the sub-health state of the organism is beneficial to improving the immunity of the organism, and in recent years, along with the improvement of the life quality of people, people are more and more aware of the importance of enhancing the physique, relieving fatigue, improving the immunity and adaptability to health, and the medicine for resisting fatigue and improving the immunity of the organism is also more and more widely concerned.
At present, various medicines for resisting fatigue and improving the immunity of the organism are sold in the market, and the action effects of the medicines are different.
Disclosure of Invention
In order to solve the defects in the prior art, the invention aims to provide the application of the pearl ganoderma preparation in preparing the medicines for resisting fatigue and treating low immunity, obtain good clinical effect, have obvious curative effect, high cure rate, short course of treatment and no toxic or side effect, and provide a new medicine selection for resisting fatigue and treating low immunity.
In order to solve the technical problems, the invention is realized by the following technical scheme:
the traditional Chinese medicine components can be replaced by traditional Chinese medicines with the same or similar efficacies, and the traditional Chinese medicines can be processed according to the national traditional Chinese medicine processing standard.
The application of the pearl ganoderma preparation in preparing the medicine for resisting fatigue and low immunity is disclosed, wherein the pearl ganoderma preparation comprises the following components in parts by weight: 35-75 parts of ganoderma lucidum extract, 30-60 parts of glossy privet fruit, 60-150 parts of turmeric root-tuber, 60-150 parts of nutgrass galingale rhizome, 35-75 parts of yerbadetajo herb, 60-150 parts of tangerine peel and 15-35 parts of pearl layer powder.
As a preferred embodiment of the application of the pearl ganoderma preparation in preparing the medicine for resisting fatigue and low immunity, the pearl ganoderma preparation comprises the following components in parts by weight: 40-65 parts of ganoderma lucidum extract, 35-55 parts of glossy privet fruit, 70-120 parts of turmeric root-tuber, 70-120 parts of nutgrass galingale rhizome, 40-65 parts of yerbadetajo herb, 80-130 parts of tangerine peel and 20-30 parts of pearl layer powder.
As a preferred embodiment of the application of the pearl ganoderma preparation in preparing the medicine for resisting fatigue and low immunity, the pearl ganoderma preparation comprises the following components in parts by weight: 45 parts of ganoderma lucidum extract, 40 parts of glossy privet fruit, 80 parts of turmeric root-tuber, 85 parts of nutgrass galingale rhizome, 60 parts of yerbadetajo herb, 85 parts of tangerine peel and 26 parts of pearl layer powder.
As a preferred embodiment of the application of the pearl ganoderma preparation in preparing the medicine for resisting fatigue and low immunity, the pearl ganoderma preparation comprises the following components in parts by weight: 50 parts of ganoderma lucidum extract, 50 parts of glossy privet fruit, 100 parts of turmeric root-tuber, 100 parts of nutgrass galingale rhizome, 50 parts of yerbadetajo herb, 100 parts of tangerine peel and 25 parts of pearl layer powder.
As a preferred embodiment of the application of the pearl ganoderma preparation in preparing the medicine for resisting fatigue and low immunity, the medicine is an oral administration preparation.
As a preferred embodiment of the application of the pearl ganoderma preparation in preparing the medicine for resisting fatigue and low immunity, the dosage form of the medicine is tablets, granules, capsules, dripping pills or oral liquid; thereby improving the convenience of the use of the medicine, increasing the absorption utilization rate of the medicine and improving the universality of the use.
As a preferred embodiment of the application of the pearl ganoderma preparation in preparing the medicine for resisting fatigue and low immunity, the pearl ganoderma preparation is prepared by the following method:
s1, weighing the raw materials according to the proportion of each component in the formula;
s2, adding water into the weighed fructus ligustri lucidi, radix curcumae, rhizoma cyperi, herba ecliptae and pericarpium citri reticulatae, decocting twice for 1-3 hours each time, adding water which is 5-12 times of the total weight of the raw materials each time, combining the decoctions, standing, filtering, and concentrating the filtrate to thick paste with the relative density of 1.20-1.35 at 50-60 ℃;
s3, adding nacreous layer powder into the thick paste, stirring uniformly, drying, adding ganoderma lucidum extract, and grinding to obtain fine powder;
s4, preparing the fine powder into a clinically acceptable oral administration preparation directly through a conventional process or by adding pharmaceutically acceptable auxiliary materials.
In the formula of the pearl ganoderma preparation, the components are compatible, synergistic and synergistic, so that the pearl ganoderma preparation can regulate the internal environment of a human body to keep stable, eliminate harmful free radicals in the human body, repair damaged cells, supplement and regulate qi and blood of the human body, can be used as a regulator of the functions of the human body, can assist in stimulating an immune system, promotes the realization of healthy constitution with normal microcirculation in the human body, enhances the immune function of the human body, fundamentally enhances the immune capacity of the human body, increases the defense capacity of the human body to stimulation, and achieves the effect of strengthening the body.
In the preparation method of the pearl ganoderma preparation, a decoction mode is adopted, so that effective components of the traditional Chinese medicines can be effectively leached in water, the effective components are extracted, harmful components are separated, and the optimal effect is achieved.
Based on the technical scheme, the invention has the following technical effects:
(1) in the application of the pearl ganoderma preparation in preparing the medicines for treating fatigue and low immunity, the pearl ganoderma preparation fully considers meridian tropism and flavor of each traditional Chinese medicine, such as: according to the ' Shennong Bencao Jing ', the ganoderma lucidum can tonify liver qi, calm soul ', eat for a long time, lose weight, prolong life, and has the functions of regulating the functions of a nervous system, a respiratory system and a cardiovascular system, regulating the functions of immunity, removing free radicals, balancing metabolism and the like, and directly influences the aging process of a human body; the proportion of the components in the pearl ganoderma preparation reduces the mutual antagonism effect of the medicines to the maximum extent, so that the traditional Chinese medicines are mutually matched and act together according to the compatibility of medicines, the aerobic metabolism is increased, the fatigue elimination and physical strength recovery are accelerated, the rest health-preserving regulation effect of heart, liver, spleen, lung and kidney is enhanced, the timely nutrition relief to the internal organs is obtained, the qi and blood of the body are supplemented and regulated, harmful free radicals are eliminated, the immune system can be stimulated, the normal operation of microcirculation in the body is promoted, the individual immunity is fundamentally enhanced, the individual defense capability to stimulation is increased, the excitation process of the central nervous system is regulated, the regulation effect of cerebral cortex is improved, and the effect of relieving fatigue is achieved; the traditional Chinese medicine composition has the effects of resisting fatigue and improving immunity, and simultaneously has the advantages of mild medicine property, obvious effect, no side effect, quick response, high cure rate, short treatment course and no toxic or side effect.
(2) In the application of the pearl-ganoderma preparation in preparing the medicines for treating fatigue and low immunity, the components in the pearl-ganoderma preparation are reasonably compatible, the effective components and the action mechanism are clear, the pearl-ganoderma preparation achieves the effects of resisting fatigue and enhancing immunity while ensuring the safety, and has wide clinical application prospect.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the specific embodiments illustrated. The invention provides a preferred embodiment. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
Example 1
The embodiment discloses an application of a pearl ganoderma preparation in preparing a medicine for resisting fatigue and low immunity, wherein the pearl ganoderma preparation comprises the following components in parts by weight: 35 parts of ganoderma lucidum extract, 30 parts of glossy privet fruit, 60 parts of turmeric root-tuber, 60 parts of nutgrass galingale rhizome, 35 parts of yerbadetajo herb, 60 parts of tangerine peel and 15 parts of pearl layer powder.
The dosage form of the pearl ganoderma preparation is tablets, and further, the pearl ganoderma tablet is prepared by adopting the following method:
s1, weighing the raw materials according to the proportion of each component in the formula;
s2, adding water into the weighed fructus ligustri lucidi, radix curcumae, rhizoma cyperi, herba ecliptae and pericarpium citri reticulatae, decocting twice for 1 hour each time, adding water which is 5 times of the total weight of the raw materials each time, combining decoction, standing, filtering, and concentrating the filtrate to thick paste with the relative density of 1.20 at 50 ℃;
s3, adding nacreous layer powder into the thick paste, stirring uniformly, drying, adding ganoderma lucidum extract, and grinding to obtain fine powder;
s4, sieving the fine powder, granulating, drying the granules, adding magnesium stearate, pressing into tablets or dispersible tablets, and coating sugar or film.
Example 2
The embodiment discloses an application of a pearl ganoderma preparation in preparing a medicine for resisting fatigue and low immunity, wherein the pearl ganoderma preparation comprises the following components in parts by weight: 75 parts of ganoderma lucidum extract, 60 parts of glossy privet fruit, 150 parts of turmeric root-tuber, 150 parts of nutgrass galingale rhizome, 75 parts of yerbadetajo herb, 150 parts of tangerine peel and 35 parts of pearl layer powder.
The dosage form of the pearl lucid ganoderma preparation is granules, and further the pearl lucid ganoderma granules are prepared by adopting the following method:
s1, weighing the raw materials according to the proportion of each component in the formula;
s2, adding water into the weighed fructus ligustri lucidi, radix curcumae, rhizoma cyperi, herba ecliptae and pericarpium citri reticulatae, decocting twice for 3 hours each time, adding water which is 12 times of the total weight of the raw materials each time, combining decoction, standing, filtering, and concentrating the filtrate to thick paste with the relative density of 1.35 at the temperature of 60 ℃;
s3, adding nacreous layer powder into the thick paste, stirring uniformly, drying, adding ganoderma lucidum extract, and grinding to obtain fine powder;
s4, sieving the fine powder, sieving, bagging and packaging to obtain the granule.
Example 3
The embodiment discloses an application of a pearl ganoderma preparation in preparing a medicine for resisting fatigue and low immunity, wherein the pearl ganoderma preparation comprises the following components in parts by weight: 40 parts of ganoderma lucidum extract, 35 parts of glossy privet fruit, 70 parts of turmeric root-tuber, 70 parts of nutgrass galingale rhizome, 40 parts of yerbadetajo herb, 80 parts of tangerine peel and 20 parts of pearl layer powder.
The dosage form of the pearl lucid ganoderma preparation is a capsule, and further the pearl lucid ganoderma capsule is prepared by adopting the following method:
s1, weighing the raw materials according to the proportion of each component in the formula;
s2, adding water into the weighed fructus ligustri lucidi, radix curcumae, rhizoma cyperi, herba ecliptae and pericarpium citri reticulatae, decocting twice for 2 hours each time, adding water of which the amount is 6 times of the total weight of the raw materials each time, combining decoction, standing, filtering, and concentrating the filtrate to thick paste with the relative density of 1.31 at 55 ℃;
s3, adding nacreous layer powder into the thick paste, stirring uniformly, drying, adding ganoderma lucidum extract, and grinding to obtain fine powder;
s4, sieving the fine powder with a 80-mesh sieve, adding 10% of prepared starch, mixing, granulating with 70% ethanol, drying, grading, and encapsulating to obtain capsule.
Example 4
The embodiment discloses an application of a pearl ganoderma preparation in preparing a medicine for resisting fatigue and low immunity, wherein the pearl ganoderma preparation comprises the following components in parts by weight: 65 parts of ganoderma lucidum extract, 55 parts of glossy privet fruit, 120 parts of turmeric root-tuber, 120 parts of nutgrass galingale rhizome, 65 parts of yerbadetajo herb, 130 parts of tangerine peel and 30 parts of pearl layer powder.
The dosage form of the pearl ganoderma preparation is a dripping pill, and further the pearl ganoderma dripping pill is prepared by adopting the following method:
s1, weighing the raw materials according to the proportion of each component in the formula;
s2, adding water into the weighed fructus ligustri lucidi, radix curcumae, rhizoma cyperi, herba ecliptae and pericarpium citri reticulatae, decocting twice for 2 hours each time, adding water 7 times of the total weight of the raw materials each time, combining the decoction, standing, filtering, and concentrating the filtrate to thick paste with the relative density of 1.33 at 55 ℃;
s3, adding nacreous layer powder into the thick paste, stirring uniformly, drying, adding ganoderma lucidum extract, and grinding to obtain fine powder;
s4, adding the fine powder into molten polyethylene glycol 4000, stirring, keeping the temperature at 55 deg.C, pouring into a dripping pill device, dripping into 10 deg.C liquid paraffin at a dripping speed of 30d/min, and making into dripping pill.
Example 5
The embodiment discloses an application of a pearl ganoderma preparation in preparing a medicine for resisting fatigue and low immunity, wherein the pearl ganoderma preparation comprises the following components in parts by weight: 45 parts of ganoderma lucidum extract, 40 parts of glossy privet fruit, 80 parts of turmeric root-tuber, 85 parts of nutgrass galingale rhizome, 60 parts of yerbadetajo herb, 85 parts of tangerine peel and 26 parts of pearl layer powder.
The dosage form of the pearl ganoderma preparation is oral liquid, and further the pearl ganoderma oral liquid is prepared by adopting the following method:
s1, weighing the raw materials according to the proportion of each component in the formula;
s2, adding water into the weighed fructus ligustri lucidi, radix curcumae, rhizoma cyperi, herba ecliptae and pericarpium citri reticulatae, decocting twice for 2 hours each time, adding water of 8 times of the total weight of the raw materials each time, combining decoction, standing, filtering, and concentrating the filtrate to thick paste with the relative density of 1.25 at 56 ℃;
s3, adding nacreous layer powder into the thick paste, stirring uniformly, drying, adding ganoderma lucidum extract, and grinding to obtain fine powder;
s4, adding sucrose into boiling water to dissolve, filtering, making into simple syrup, mixing with the fine powder, simple syrup, 0.2% potassium sorbate, and purified water, stirring, dissolving, sterilizing in high pressure steam cooker, and packaging to obtain oral liquid.
Example 6
The embodiment discloses an application of a pearl ganoderma preparation in preparing a medicine for resisting fatigue and low immunity, wherein the pearl ganoderma preparation comprises the following components in parts by weight: 50 parts of ganoderma lucidum extract, 50 parts of glossy privet fruit, 100 parts of turmeric root-tuber, 100 parts of nutgrass galingale rhizome, 50 parts of yerbadetajo herb, 100 parts of tangerine peel and 25 parts of pearl layer powder.
The dosage form of the pearl ganoderma preparation is tablets, and further, the pearl ganoderma tablet is prepared by adopting the following method:
s1, weighing the raw materials according to the proportion of each component in the formula;
s2, adding water into the weighed fructus ligustri lucidi, radix curcumae, rhizoma cyperi, herba ecliptae and pericarpium citri reticulatae, decocting twice for 2 hours each time, adding water 7 times of the total weight of the raw materials each time, combining the decoction, standing, filtering, and concentrating the filtrate to thick paste with the relative density of 1.29 at 56 ℃;
s3, adding nacreous layer powder into the thick paste, stirring uniformly, drying, adding ganoderma lucidum extract, and grinding to obtain fine powder;
s4, sieving the fine powder, granulating, drying the granules, adding magnesium stearate, pressing into tablets or dispersible tablets, and coating sugar or film.
Example 7 Effect of the Pearl Ganoderma preparation of the present invention on anti-fatigue of mice
Experimental animals: the number of healthy Kunming male mice is 160, the weight of the healthy Kunming male mice is 18-22g, the healthy Kunming male mice are randomly divided into four groups, and each group comprises 40 mice; the control group is subjected to intragastric administration with physiological saline, the experimental group is subjected to intragastric administration with liquid medicines with corresponding concentrations of the high, medium and low dose groups (10.5, 5.5 and 2.5 g/kg) of the medicine of the invention in example 6, the intragastric volume is 0.1ml/10g, and the experiment is carried out after 30 days of administration.
Firstly, measuring the weight swimming time:
10 mice were randomly selected for each group, administered for 30 days, and after the last administration, the tail of each mouse was loaded with a lead sheet equivalent to 5% of the body weight, and then placed in a swimming box at a water temperature of 27 + -3 ℃ and a water depth of 35cm, and the time from the beginning of swimming to death of the mouse was recorded as the swimming time of the mouse, and table 1 shows the measurement results of the swimming time under load.
Note: p <0.05, P <0.01, compared to placebo
The results in table 1 show that, compared with the control group, the middle and high dose groups of the drug in example 3 of the present invention can significantly improve the swimming time of the loaded mice in water, and P is less than 0.05, which indicates that the drug of the present invention can significantly prolong the continuous swimming time of the mice, effectively alleviate fatigue symptoms, enhance the anti-fatigue capability of the bodies of the mice, and have significant anti-fatigue and physical strength enhancing effects.
Secondly, measuring the content of hepatic glycogen;
10 mice were randomly selected for each group, administered for 30 days, and after the last administration, the mice were placed in a swimming chamber with water temperature (27 + -3) deg.C for 90 minutes, and then the liver was taken out and the liver glycogen content was measured by the anthrone method, and the results are shown in Table 2.
The results in Table 2 show that the low, medium and high dose groups of the drug of example 3 can significantly increase the liver glycogen content of mice compared with the control group, which indicates that the drug of the invention has the effect of increasing glycogen storage of mice.
Thirdly, measuring the weight of the immune organs of the mice:
10 mice were randomly selected for each group, the mice were dosed for 30 days, and after the end of the last dose, the organs of the mice were taken and weighed, and the results are shown in table 3.
The results in table 3 show that, compared with the control group, the low, medium and high dose groups of the drug of the invention in example 3 all significantly improve the weight of the immune organs of mice, and P is less than 0.05, which indicates that the drug of the invention has the function of significantly improving the body immunity.
Fourth, experiment of mouse lymphocyte transformation induced by ConA:
selecting 10 mice per group at random, administering for 30 days, aseptically taking spleens of mice after the last administration to obtain single cell suspension, and mixing the obtained cell suspension with the ratio of 3 x 106One well (1mL) was placed in a 24-well plate, 2 wells were placed in each group, 75. mu.L of ConA solution was added to one well, and the same amount of physiological saline was added as a control, and 5% CO was added to the other well2Culturing in an incubator at 37 ℃; after 24 hours, replacing fresh RPMI1640 cell culture solution, adding MTT 50 mu L/hole, and continuing to culture for 4 hours; after the culture is finished, 1mL of isopropanol hydrochloride is added, the mixture is uniformly blown and beaten, after the crystals are completely dissolved, the mixture is subpackaged on a 96-hole culture plate, 3 controls are arranged in each hole, the optical density value is measured on a microplate reader at 570nm, and the experimental results are shown in Table 4.
The results in table 4 show that the absorbance values of the low, medium and high dose groups of the drug of example 3 of the present invention are significantly different from the control values (P <0.01), which indicates that the drug of the present invention has significant antiviral and immunity enhancing effects.
EXAMPLE 8 clinical effects of the Pearl-Ganoderma preparation of the present invention
And (3) judging the curative effect:
1. case selection: 140 patients with fatigue and hypoimmunity are selected, the age range is 25-65 years old, wherein 89 male patients and 81 female patients are randomly divided into two groups, each group comprises 70 patients, and the two groups are respectively a treatment group and a control group, wherein the statistical treatment of the groups on age, sex, disease conditions and the like has no significant difference (P is more than 0.05) and has comparability.
2. Evaluation criteria:
and (4) relieving the following steps: the face is ruddy, the energy is vigorous, the limbs are powerful, the physical strength and the immunity are improved, the antiviral ability is enhanced, and symptoms such as headache, fatigue, amnesia and the like disappear;
partial mitigation: the spirit and the face color are all improved, the limbs are gradually strong, the physical strength and the immunity are also recovered, and symptoms such as headache, fatigue, amnesia and the like are gradually disappeared;
and (4) invalidation: no improvement in symptoms was observed.
3. The treatment method comprises the following steps: the treatment group adopts the oral liquid of the embodiment 5 of the invention, 1 bottle of the oral liquid is taken each time, three times a day, the oral liquid is taken in the morning, the noon and the evening, one month is a treatment course, two treatment courses are continuously taken, and the treatment effect is observed; the control group orally takes the Guilingji capsules 2 capsules each time, once a day, one month as a treatment course, two treatment courses are continuously taken, and the treatment effect is observed.
4. Statistics of treatment results: wherein, the cure rate = (total remission + partial remission)/number of cases
The clinical observations are as follows:
as is apparent from table 5, the cure rate of the treatment group taking the oral liquid obtained in example 5 of the present invention was 92.9%, and the cure rate of the control group was 82.9%, which indicates that the pearl ganoderma preparation of the present invention has significant improvement in the treatment effect on fatigue and low immunity compared to the treatment effect using the tortoise plastron capsules.
The tests prove that the pearl-ganoderma preparation provided by the invention is applied to the preparation of the medicines for treating fatigue and low immunity, the pearl-ganoderma preparation is scientific and reasonable in compatibility of Chinese herbal medicines, the medicinal effects supplement each other and complement each other, the effective components and the action mechanism are relatively clear, and the pearl-ganoderma preparation has a relatively strong synergistic effect, can promote the recovery of body fatigue, improve the body immunity, especially improve the fatigue resistance of the body, enable the body to be full of energy, improve the memory, has no toxic or side effect, has no addiction, and has the advantages of remarkable effect, short treatment course and high cure rate; the pearl ganoderma preparation has the advantages of simple preparation, wide medicine source, low cost, mild medicine property, no toxic or side effect and suitability for popularization and use, and all the components of the pearl ganoderma preparation are selected from Chinese herbal medicine raw materials.
The pearl ganoderma preparation provided by the invention can be prepared into oral administration preparations such as tablets, granules, capsules, dripping pills or oral liquid and the like, has the effects of accelerating fatigue elimination and physical strength recovery and enhancing immunity, achieves the effects of treating fatigue and low immunity, does not need other medicines for matching, can strengthen body resistance and eliminate pathogenic factors, takes the symptoms and root causes into consideration, enables patients to recover and keep stable, and has low recurrence rate.
The above-mentioned embodiments only express the embodiments of the present invention, and the description is more specific and detailed, but not understood as the limitation of the patent scope of the present invention, but all the technical solutions obtained by using the equivalent substitution or the equivalent transformation should fall within the protection scope of the present invention.
Claims (7)
1. The application of the pearl ganoderma preparation in preparing the medicine for resisting fatigue and low immunity is characterized in that the pearl ganoderma preparation comprises the following components in parts by weight: 35-75 parts of ganoderma lucidum extract, 30-60 parts of glossy privet fruit, 60-150 parts of turmeric root-tuber, 60-150 parts of nutgrass galingale rhizome, 35-75 parts of yerbadetajo herb, 60-150 parts of tangerine peel and 15-35 parts of pearl layer powder.
2. The application of the pearl ganoderma preparation in preparing the medicines for resisting fatigue and low immunity according to claim 1, wherein the pearl ganoderma preparation comprises the following components in parts by weight: 40-65 parts of ganoderma lucidum extract, 35-55 parts of glossy privet fruit, 70-120 parts of turmeric root-tuber, 70-120 parts of nutgrass galingale rhizome, 40-65 parts of yerbadetajo herb, 80-130 parts of tangerine peel and 20-30 parts of pearl layer powder.
3. The application of the pearl ganoderma preparation in preparing the medicines for resisting fatigue and low immunity according to claim 1, wherein the pearl ganoderma preparation comprises the following components in parts by weight: 45 parts of ganoderma lucidum extract, 40 parts of glossy privet fruit, 80 parts of turmeric root-tuber, 85 parts of nutgrass galingale rhizome, 60 parts of yerbadetajo herb, 85 parts of tangerine peel and 26 parts of pearl layer powder.
4. The application of the pearl ganoderma preparation in preparing the medicines for resisting fatigue and low immunity according to claim 1, wherein the pearl ganoderma preparation comprises the following components in parts by weight: 50 parts of ganoderma lucidum extract, 50 parts of glossy privet fruit, 100 parts of turmeric root-tuber, 100 parts of nutgrass galingale rhizome, 50 parts of yerbadetajo herb, 100 parts of tangerine peel and 25 parts of pearl layer powder.
5. The use of the preparation of claim 1 for the preparation of a medicament for the treatment of fatigue and hypoimmunity, wherein the medicament is an oral dosage formulation.
6. The use of the preparation of claim 1 in the preparation of a medicament for the treatment of fatigue and hypoimmunity, wherein the dosage form of the medicament is tablet, granule, capsule, drop pill or oral liquid.
7. The application of the pearl ganoderma preparation in preparing the medicine for resisting fatigue and low immunity according to claim 1, wherein the pearl ganoderma preparation is prepared by adopting the following method:
s1, weighing the raw materials according to the proportion of each component in the formula;
s2, adding water into the weighed fructus ligustri lucidi, radix curcumae, rhizoma cyperi, herba ecliptae and pericarpium citri reticulatae, decocting twice for 1-3 hours each time, adding water which is 5-12 times of the total weight of the raw materials each time, combining the decoctions, standing, filtering, and concentrating the filtrate to thick paste with the relative density of 1.20-1.35 at 50-60 ℃;
s3, adding nacreous layer powder into the thick paste, stirring uniformly, drying, adding ganoderma lucidum extract, and grinding to obtain fine powder;
s4, the fine powder is directly processed by the conventional process or added with pharmaceutically acceptable auxiliary materials to be prepared into clinically acceptable oral administration preparations.
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| CN106728703A (en) * | 2017-03-09 | 2017-05-31 | 吉林大学珠海学院 | A kind of antifatigue, enhance immunity herbal mixture oral liquid and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 周宝宽;: "抗疲劳防治亚健康中药整理与研究" * |
| 陈细兰;曾英彤;黄清松;: "珍珠灵芝片对小鼠免疫功能和抑瘤作用的研究" * |
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