CN110935238A - Micro-nano particle enrichment device based on coupling of variable cross-section microchannel and viscoelastic fluid - Google Patents
Micro-nano particle enrichment device based on coupling of variable cross-section microchannel and viscoelastic fluid Download PDFInfo
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- CN110935238A CN110935238A CN201911233648.2A CN201911233648A CN110935238A CN 110935238 A CN110935238 A CN 110935238A CN 201911233648 A CN201911233648 A CN 201911233648A CN 110935238 A CN110935238 A CN 110935238A
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Abstract
The micro-nano particle enrichment device based on coupling of the variable cross-section microchannel and the viscoelastic fluid consists of an inlet, an outlet, a side wall and an internal cavity; the outlines of the inlet and the outlet are closed curves; the inlet area is greater than the outlet area; in the flow direction, the cross section of the inner cavity is gradually reduced; the micron or nanometer particles are dispersed in the viscoelastic fluid and enter the internal cavity through the inlet, the viscoelastic fluid enables the particles to be acted by elastic force pointing to the center of the channel, but the action is weaker, the variable cross-section microchannel can change the direction of the elastic force on the particles and induce a velocity component pointing to the center of the channel, so that the particles are acted by viscous drag force, Saffman force and the like pointing to the center of the channel, the movement of the particles to the center of the channel is further accelerated, the micron or nanometer particles quickly move to the center of the channel under the coupling action of the variable cross-section microchannel and the viscoelastic fluid, and finally, efficient enrichment and arrangement are realized at the outlet of the microchannel; the invention can realize the high-efficiency enrichment and arrangement of micron or nano particles, and has important application potential in the fields of biomedicine and the like.
Description
Technical Field
The invention relates to a particle enrichment device, in particular to a micro-nano particle enrichment device based on coupling of a variable cross-section microchannel and a viscoelastic fluid.
Background
The high-efficiency enrichment of the micron or nano particles has important application value in the fields of biomedicine and the like. For example, in biomedicine, blood cells are efficiently enriched into a straight line, different blood cells sequentially pass through a detection area, and information such as the types and the number of various blood cells can be obtained, so that the method has important significance for early diagnosis and disease condition monitoring of diseases. In addition, in the early stage of some diseases, the concentration of pathological cells or related nano-scale proteins is low, and the efficient enrichment of such micro-or nano-particles is beneficial to improving the detection accuracy. Currently, the approaches for micro-or nanoparticle enrichment mainly include both active and passive approaches. The active mode needs an external force field, the structure is complex, and the energy consumption is high. Compared with the passive particle enrichment mode, the passive particle enrichment mode does not need an external force field, and is simple in structure by only depending on the interaction of fluid and particles. However, the passive particle enrichment precision is low at present, and especially the enrichment efficiency aiming at nano-scale particles is extremely low. There is therefore a need to develop methods for the efficient enrichment of micro-and nano-sized particles.
Disclosure of Invention
The invention aims to provide a micro-nano particle enrichment device based on the coupling effect of a variable cross-section microchannel and a viscoelastic fluid, which can efficiently enrich micron or nano-scale particles such as cells, viruses and proteins, has the advantages of simple structure, low cost, high efficiency and the like, and has good application prospects in the fields of biomedicine, clinical diagnosis, treatment and the like.
In order to achieve the purpose, the invention adopts the following technical scheme:
the micro-nano particle enrichment device based on coupling of the variable cross-section microchannel and the viscoelastic fluid consists of an inlet 1, an outlet 3, a side wall 2 and an internal cavity 5; the outlines of the inlet 1 and the outlet 3 are closed curves; the area of the inlet 1 is larger than that of the outlet 3; the inner cavity 5 is a micro-channel with variable cross section, and the cross section is gradually reduced in the flow direction; the micron or nanometer particles are dispersed in the viscoelastic fluid 4 and enter the inner cavity 5 through the inlet 1, the viscoelastic fluid 4 enables the micron or nanometer particles to be subjected to elastic force action pointing to the center of the variable cross-section microchannel, but the action is weaker, the variable cross-section microchannel can change the direction of the elastic force of the micron or nanometer particles and induce a velocity component pointing to the center of the variable cross-section microchannel, the particles are subjected to viscous drag force pointing to the center of the variable cross-section microchannel, Saffman force and the like, the movement of the particles to the center of the variable cross-section microchannel is further accelerated, the micron or nanometer particles gradually move to the center of the microchannel under the coupling action of the variable cross-section microchannel and the viscoelastic fluid 4, and finally, the enrichment and the arrangement are realized at the outlet 3 of the microchannel.
The outlines of the inlet 1 and the outlet 3 are closed curves and are in a circular shape, a square shape, a rectangular shape, a trapezoidal shape, a triangular shape or other irregular shapes.
The viscoelastic fluid 4 is, for example, a polyethylene oxide (PEO) solution, a polyvinylpyrrolidone (PVP) solution, or the like.
Compared with the prior art, the invention has the following advantages:
1) the particle enrichment efficiency is high. Viscoelastic fluids, while they can subject the particles to an elastic force directed toward the center of the channel, are less effective. According to the invention, the variable cross-section microchannel is used for changing the direction of the elastic force applied to the micro-or nano-particles, so that a velocity component pointing to the center of the variable cross-section microchannel is initiated, the micro-or nano-particles are subjected to the effects of viscous drag force pointing to the center of the variable cross-section microchannel, Saffman force and the like, the movement of the particles to the center of the variable cross-section microchannel is accelerated, the micro-or nano-particles quickly move to the center of the variable cross-section microchannel under the coupling action of the variable cross-section microchannel and viscoelastic fluid, and finally, efficient enrichment and arrangement are realized at the outlet of the variable cross-section microchannel.
2) The structure is simple. The invention only needs the variable cross-section micro-channel, does not need external force fields such as an electric field, an ultrasonic field and the like to control the particles, does not need the sheath flow effect, and greatly simplifies the structure of the device.
3) The operation is easy. According to the invention, only the function of the variable cross-section microchannel and the viscoelastic fluid is needed to be combined, the target particles are dispersed in the viscoelastic fluid and are introduced from the inlet of the variable cross-section microchannel, and the efficient enrichment of the particles at the outlet of the microchannel can be realized.
4) The application range of the particles is wide. Can realize the high-efficiency enrichment of micron and nano particles.
Drawings
FIG. 1 is a schematic diagram of the efficient enrichment of particles based on the coupling effect of a variable cross-section microchannel and a viscoelastic fluid.
Detailed Description
The invention is described in further detail below with reference to the following figures and detailed description:
as shown in fig. 1, the micro-nano particle enrichment device based on the coupling effect of the variable cross-section microchannel and the viscoelastic fluid comprises an inlet 1, an outlet 3, a side wall 2 and an internal cavity 5; the outlines of the inlet 1 and the outlet 3 are closed curves; the area of the inlet 1 is larger than that of the outlet 3; the inner cavity 5 is a micro-channel with variable cross section, and the cross section is gradually reduced in the flow direction; the micron or nanometer particles are dispersed in the viscoelastic fluid 4 and enter the inner cavity 5 through the inlet 1, the viscoelastic fluid 4 enables the micron or nanometer particles to be subjected to elastic force action pointing to the center of the variable cross-section microchannel, but the action is weaker, the variable cross-section microchannel can change the direction of the elastic force of the micron or nanometer particles and induce a velocity component pointing to the center of the variable cross-section microchannel, the micron or nanometer particles are subjected to viscous drag force, Saffman force and the like pointing to the center of the variable cross-section microchannel, the movement of the particles to the center of the variable cross-section microchannel is further accelerated, the micron or nanometer particles gradually move to the center of the variable cross-section microchannel under the coupling action of the variable cross-section microchannel and the viscoelastic fluid 4, and efficient enrichment and arrangement are finally achieved at the outlet 3 of the variable cross-section microchannel.
In the present invention, the contour of the inlet 1 and the outlet 3 is a closed curve of a circle, a square, a rectangle, a trapezoid, a triangle or other irregular shapes.
As a preferred embodiment of the present invention, the micro-or nanoparticles are dispersed in a viscoelastic fluid 4, such as a polyethylene oxide PEO solution, a polyvinylpyrrolidone PVP solution, or the like.
The following describes the implementation of the present invention in one embodiment:
the specific operation of the invention for efficiently enriching the micron or nanometer particles is as follows, the micron or nanometer particles are dispersed in the viscoelastic fluid 4, and the viscoelastic fluid can adopt polyethylene oxide (PEO) solution, polyvinylpyrrolidone (PVP) solution and the like. A viscoelastic fluid 4 containing micro-or nanoparticles is subjected to an internal cavity 5 via the inlet 1 of the channel, moving from the inlet 1 of the channel to the outlet 3 of the channel. The viscoelastic fluid 4 enables the micro-or nano-particles to be acted by elastic force pointing to the center of the variable cross-section microchannel, but the action is weaker, the variable cross-section microchannel can change the direction of the elastic force received by the particles and induce a velocity component pointing to the center of the variable cross-section microchannel, so that the particles are acted by viscous drag force pointing to the center of the channel, Saffman force and the like, the movement of the particles to the center of the variable cross-section microchannel is further accelerated, and under the coupling action of the variable cross-section microchannel and the viscoelastic fluid 4, the efficient enrichment of the nano-particles is finally realized at the outlet 3 of the variable cross-section microchannel. In conclusion, the invention is based on the coupling effect of the variable cross-section microchannel and the viscoelastic fluid, can effectively enrich micron or nanometer level particles, has the advantages of high efficiency, simple structure, easy operation, wide applicability and the like, and has important application potential in the fields of biomedicine and the like.
Claims (3)
1. The micro-nano particle enrichment device based on coupling of the variable cross-section microchannel and the viscoelastic fluid consists of an inlet (1), an outlet (3), a side wall (2) and an internal cavity (5); the method is characterized in that: the outlines of the inlet (1) and the outlet (3) are closed curves; the area of the inlet (1) is larger than that of the outlet (3); the inner cavity (5) is a variable cross-section micro-channel, and the cross section of the inner cavity is gradually reduced in the flow direction; the micron or nanometer particles are dispersed in the viscoelastic fluid (4) and enter the inner cavity (5) through the inlet (1), the viscoelastic fluid (4) enables the micron or nanometer particles to be subjected to elastic force action pointing to the center of the variable cross-section microchannel, but the action is weaker, the variable cross-section microchannel can change the direction of the elastic force applied to the micron or nanometer particles and trigger a velocity component pointing to the center of the variable cross-section microchannel, the particles are subjected to viscous drag force and Saffman force action pointing to the center of the variable cross-section microchannel, the movement of the particles to the center of the variable cross-section microchannel is further accelerated, and enrichment and arrangement are finally realized at the outlet (3) of the variable cross-section microchannel efficiently under the coupling action of the variable cross-section microchannel and the viscoelastic fluid (4).
2. The micro-nano particle enrichment device based on variable cross-section microchannel and viscoelastic fluid coupling of claim 1, characterized in that: the closed curve is in a shape of circle, square, rectangle, trapezoid, triangle or irregular shape.
3. The micro-nano particle enrichment device based on variable cross-section microchannel and viscoelastic fluid coupling of claim 1, characterized in that: the viscoelastic fluid (4) is a polyethylene oxide (PEO) solution or a polyvinylpyrrolidone (PVP) solution.
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| CN113042120A (en) * | 2021-03-24 | 2021-06-29 | 西安交通大学 | Micro-fluidic device for efficiently separating particles in viscoelastic fluid |
| CN113769797A (en) * | 2021-09-02 | 2021-12-10 | 浙江理工大学 | Method for measuring diameter of micro-scale particles in fluid-solid two-phase transportation |
| CN113954364A (en) * | 2021-09-22 | 2022-01-21 | 西安交通大学 | Micron or nanometer aerosol particle enrichment device |
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