CN110889848A - System and device for processing overlapping region of interest - Google Patents

System and device for processing overlapping region of interest Download PDF

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CN110889848A
CN110889848A CN201911265456.XA CN201911265456A CN110889848A CN 110889848 A CN110889848 A CN 110889848A CN 201911265456 A CN201911265456 A CN 201911265456A CN 110889848 A CN110889848 A CN 110889848A
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interest
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CN110889848B (en
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张康
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Shanghai United Imaging Healthcare Co Ltd
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Abstract

The embodiment of the invention discloses a system and a device for processing an overlapping area of an interested area. The system includes a processor configured to: receiving an image of a target object containing a first region of interest and a second region of interest, wherein the regions of interest are mutually overlapped to form an overlapping region; the overlapping region is divided by a first dose volume target of the first region of interest and a second dose volume target of the second region of interest to determine a first target region and a second target region; the dose targets for the first and second target regions are set according to the first and second dose volume targets. The technical scheme of the embodiment of the invention realizes that the user can more conveniently and intuitively process the radiotherapy plan design with organ overlapping, and improves the efficiency and the plan quality of the radiotherapy used by the user.

Description

System and device for processing overlapping region of interest
Technical Field
The embodiment of the invention relates to the technical field of medical treatment, in particular to a system and a device for processing an overlapping area of an interested area.
Background
When a physicist optimizes radiotherapy Planning using a radiotherapy Planning System (TPS), situations are often encountered in which a Target region (Target ROI) and a protective organ (OAR ROI) overlap, such as the Target region and the left and right parotid glands in case of nasopharyngeal carcinoma, the Target region and the bladder, rectum in case of cervical carcinoma, and so on. In general, the radiation therapy requirements are to try to achieve the prescribed dose within the radiation target while minimizing the dose deposition to normal tissue surrounding the target. Therefore, in planning the treatment of a target area overlapping with a protective organ, the user tends to run into a dilemma: first, the target dose necessarily results in overdose of the protective organs in the overlap region; secondly, if the organ is protected and set according to stricter conditions, the target area is insufficient in the region.
In the prior art, when a physicist performs plan optimization by using the existing TPS, since a TPS optimization algorithm is used to treat an overlapping region of a target region and a protective organ, final dose results are uncertain in the overlapping region because Voxel points (Voxel) at the same position are limited by two types of constraints. Therefore, in the planning and designing process, the user limits the amount of the protected organ according to the condition of illness and medication of the patient, and the position and volume of each organ, and repeatedly adjusts the optimization conditions according to the dosage result in the subsequent optimization process so as to achieve the balance between the target area and the protected organ. The method specifically comprises the following treatment modes: deducting the protected organ in the target area by using a delineation tool, or deducting the target area in the protected organ, and setting constraint conditions in an optimization objective function by using the subtracted target area or the protected organ as a new target area and the protected organ; by utilizing priority setting provided in TPS, only the target area is considered to reach the target dosage when the target area has priority; when the protection organ is prioritized, the target of the protection organ is prioritized; by using the function of inputting a contraction (shrnk) distance provided in the TPS, contraction processing of a user-specified distance is performed on the target region, thereby achieving the purpose of considering the target region and the protected organ at the same time. However, when the user is performing the above procedure, there is often a large uncertainty in the dose distribution generated at the target region and the organ protection overlap region when the organ is transitioned or the optimized parameter settings are not appropriate.
Disclosure of Invention
The embodiment of the invention provides a system and a device for processing an overlapping region of a region of interest, so that a user can more conveniently, reasonably and intuitively process a radiotherapy plan design with organ overlapping, the efficiency of using TPS by the user and the plan quality are improved, when the user sets a constraint condition of protecting an organ, the ideal dose result of the target region and the voxel of the overlapping region under the condition of giving a dose target of the protecting organ can be visually seen in real time, and the uncertainty judgment of the final result of the radiotherapy plan by the user is reduced.
In a first aspect, an embodiment of the present invention provides a system for processing an overlapping area of a region of interest, including a processor, where the processor is configured to:
receiving an image of a target object, wherein the image comprises a first region of interest and a second region of interest, and the first region of interest and the second region of interest are overlapped with each other to form an overlapping region;
dividing the overlapping region according to a first dose volume target of the first region of interest and a second dose volume target of the second region of interest to determine a first target region and a second target region;
setting the dose objectives of the first and second target regions in accordance with the first and second dose volume objectives.
Further, the processor is further configured to:
dividing the overlap region according to a first dose volume target of the first region of interest and a second dose volume target of the second region of interest to determine a third target region, the first target region and the second target region together constituting the overlap region;
setting a dose target for the third target region according to the first dose volume target and the second dose volume target.
Further, the processor is further configured to:
and displaying the first region of interest, the second region of interest, the first target region and the second target region, and the volume information corresponding to each region.
Further, the processor is further configured to:
and modifying at least one of the first dose volume target, the second dose volume target, the first target region and the second target region, and updating the volume information corresponding to each region.
Further, the processor is further configured to:
and judging whether the first region of interest reaches the first dose volume target and/or whether the second region of interest reaches the second dose volume target according to the updated volume information.
Further, dividing the overlap region according to the first dose volume target of the first region of interest and the second dose volume target of the second region of interest to determine a first target region and a second target region, including:
determining a second target region in the overlap region according to a second dose volume target of the second region of interest, and taking a region of the overlap region from which the second target region is removed as the first target region.
Further, dividing the overlap region according to the first dose volume target of the first region of interest and the second dose volume target of the second region of interest to determine a third target region, where the third target region, the first target region and the second target region together form the overlap region, including:
determining a second target region in the overlap region from a second dose volume target of the second region of interest;
determining a third target region from the first dose volume target of the first region of interest and the second dose volume target of the second region of interest;
and taking the area of the overlapping area from which the second target area and the third target area are removed as the first target area.
Further, determining a third target region from the first dose volume target of the first region of interest and the second dose volume target of the second region of interest comprises:
determining a dose buffer distance from a first dose volume target of the first region of interest and a second dose volume target of the second region of interest, the dose buffer distance being a distance required to change from a second one of the second dose volume targets to a first one of the first dose volume targets;
and determining a third target area in the overlapping area according to the distance.
Further, the dose target of the first target region is the same as the first region of interest; the dose target of the second target region is the same as the second region of interest.
Further, the dose target of the first target region is the same as the first region of interest; the dose target of the second target region is the same as the second region of interest; the dose target of the third target region varies between the first dose target and the second dose target.
Further, the dose target of each voxel in the third target region is determined according to the dose target of the first target region, the dose target of the second target region, and the distance from each voxel point to the remaining region of the second region of interest after the first target region and the third target region are removed.
Further, the first region of interest is a protected organ region and the second region of interest is a target region.
In a second aspect, an embodiment of the present invention further provides an apparatus for processing an overlapping area of a region of interest, where the apparatus is configured in a processor, and the apparatus includes:
the image receiving module is used for receiving an image of a target object, wherein the image comprises a first region of interest and a second region of interest, and the first region of interest and the second region of interest are overlapped with each other to form an overlapping region;
a target region determination module, configured to determine a first target region and a second target region by dividing the overlap region according to a first dose volume target of the first region of interest and a second dose volume target of the second region of interest;
a dose target determination module to set dose targets for the first target region and the second target region according to the first dose volume target and the second dose volume target.
According to the technical scheme of the embodiment of the invention, the image of the target object is received, the image comprises a first region of interest and a second region of interest, and the first region of interest and the second region of interest are mutually overlapped to form an overlapping area; dividing the overlapping region according to a first dose volume target of the first region of interest and a second dose volume target of the second region of interest to determine a first target region and a second target region; the dose targets of the first target region and the second target region are set according to the first dose volume target and the second dose volume target, so that the problem that the dose distribution generated in the target region and the organ protection overlapping region has great uncertainty when a transition organ or an optimization parameter is set unreasonably is solved, the radiotherapy plan design with organ overlapping can be processed more conveniently and intuitively by a user, the efficiency and plan quality of the TPS used by the user are improved, the ideal dose result of the voxel belonging of the overlapping region and the target region under the condition of giving the dose target of the protection organ can be visually seen in real time when the constraint condition of the protection organ is set by the user, and the uncertainty judgment of the final result of the radiotherapy plan by the user is reduced.
Drawings
FIG. 1 is a flow chart of steps configured by a processor in a system for processing overlapping regions of a region of interest according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of dividing an overlapping region of a region of interest according to an embodiment of the present invention;
fig. 3 is a flowchart of steps configured by a processor in a system for processing an overlapping area of a region of interest according to a second embodiment of the present invention;
fig. 4 is a schematic diagram of forming a third target region after dividing an overlapping region of a region of interest according to an embodiment of the present invention;
fig. 5 is a block diagram of an apparatus for processing an overlapping area of a region of interest according to an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention are described in further detail below with reference to the accompanying drawings. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting of the invention.
It should be further noted that, for the convenience of description, only some but not all of the relevant aspects of the present invention are shown in the drawings. Before discussing exemplary embodiments in more detail, it should be noted that some exemplary embodiments are described as processes or methods depicted as flowcharts. Although a flowchart may describe the operations (or steps) as a sequential process, many of the operations can be performed in parallel, concurrently or simultaneously. In addition, the order of the operations may be re-arranged. The process may be terminated when its operations are completed, but may have additional steps not included in the figure. The processes may correspond to methods, functions, procedures, subroutines, and the like.
Example one
Fig. 1 is a flowchart of steps configured by a processor in a system for processing an overlapping region of a region of interest according to an embodiment of the present invention, which is applicable to processing a case where the overlapping region of the region of interest is uncertain in dose result because a voxel point is limited by two types of constraints during radiotherapy planning optimization, and the method may be performed by an apparatus for processing the overlapping region of the region of interest, which may be implemented by software and/or hardware, and which may be configured in the processor of the system for processing the overlapping region of the region of interest according to the embodiment of the present invention.
Referring to fig. 1, a system for processing an overlapping area of a region of interest according to an embodiment of the present invention may include a processor, which may be configured to:
s110, receiving an image of a target object, wherein the image comprises a first region of interest and a second region of interest, and the first region of interest and the second region of interest are overlapped to form an overlapping region.
Before a physicist uses the radiotherapy planning system to optimize radiotherapy planning, a scan of conventional modality data, such as a CT scan or an MRI scan of conventional diagnosis, is first performed to generate an image to be processed by the radiotherapy planning system, that is, to obtain an image of a to-be-detected part of a target object. The image of the target object typically contains a plurality of regions of interest. Optionally, the first region of interest is a target region and the second region of interest is a protected organ region.
Specifically, radiotherapy is a local treatment for a cancerous site of a patient, such as nasopharyngeal carcinoma, breast cancer, or brain tumor. In general, an image of the target object is acquired including an overlapping region where the target region and the protective organ region overlap with each other, for example, an overlapping region where the target region overlaps with the left and right parotid glands in the case of nasopharyngeal carcinoma, an overlapping region where the target region overlaps with the bladder or rectum in the case of cervical carcinoma, or the like. When the radiotherapy plan is optimized to treat an overlapped region where a target region and a protected organ region overlap, voxel points at the same position of the overlapped region are limited by two types of constraints, namely, dose targets of the target region and the protected organ region affect the dose target of the overlapped region, which causes the dose result of the overlapped region to become uncertain in the overlapped region. The technical scheme provided by the embodiment of the invention aims at intuitively and conveniently designing radiotherapy plan optimization of an overlapping region formed by mutually overlapping a target region and a protective organ region.
And S120, dividing the overlapping region according to the first dose volume target of the first region of interest and the second dose volume target of the second region of interest to determine a first target region and a second target region.
Wherein a second target region is determined in the overlap region according to a second dose volume target of the second region of interest, and a region of the overlap region from which the second target region is removed is taken as the first target region. The dose volume target is a constraint on the dose and volume of the region of interest, e.g., the dose volume target for the protected organ region may be such that the volume percentage of the first preset dose or more is not greater than a first threshold; the dose volume target for the target region may be a volume percentage equal to or greater than a second preset dose not less than a second threshold.
The dose targets for the voxel points within the first region of interest are set according to a first dose target in the first dose volume targets and the dose targets for the voxel points within the second region of interest are set according to a second dose target in the second dose volume targets, then the voxel points within the overlap region are acted upon by the dose targets of the first and second regions of interest in combination. In the prior art, the division of the overlapping area and the design of the objective function are usually handled according to the requirements of the doctor, the physical signs of the patient, or the personal experience of the doctor. The overlapping area planning design specifically includes: firstly, directly delineating an overlapping region through a delineation tool of a radiotherapy planning system, or generating a transition region of the overlapping region by logic operation of a user for further optimizing an objective function of the overlapping region; secondly, the priority of the interested regions is set by using a radiotherapy planning system, and the dose target of the overlapped region of the two interested regions is determined by the interested region with high priority, so that the operation of generating the transition region is omitted, but the overlapped region is basically and generally divided into one interested region; and thirdly, directly setting the dose gradient of the overlapping region by a radiotherapy planning system or processing the dose gradient by an optimization algorithm, thereby dividing a target region contained in the overlapping region. According to the technical scheme provided by the embodiment of the invention, the overlapping area is automatically divided by the dose target of the interested area, so that the overlapping area is prevented from being cut by manual operation, the balance of the two interested areas is maintained by considering the two interested areas, and the basic requirements of radiotherapy are met.
Illustratively, as shown in fig. 2, which is a schematic diagram for dividing an overlapping region of regions of interest according to an embodiment of the present invention, a first region of interest 10 is a delineated target region on a cross section, a second region of interest 20 is a delineated protected organ region on the same cross section, a positional relationship between the target region and the protected organ region on the cross section is obtained, and an overlapping region 30 shown in the upper diagram of fig. 2 is obtained, and a voxel point in the overlapping region 30 is shared by the first region of interest 10 and the second region of interest 20. The overlap region 30 shown in the lower graph of fig. 2 is divided into a first target region 40 and a second target region 50, the second target region 50 is a set of voxel points within the overlap region 30 of the first region of interest 10 and the second region of interest 20 obtained according to the volume target in the dose volume target of the second region of interest 20, the voxel points within the second target region 50 are considered to no longer belong to the first region of interest 10 in the objective function of the radiotherapy optimization algorithm, and the first target region 40 is a region of the overlap region 30 whose voxel points still belong to the first region of interest 10 after being automatically processed by the radiotherapy optimization algorithm.
S130, setting the dose targets of the first target area and the second target area according to the first dose volume target and the second dose volume target.
Wherein the dose target of the first target region is the same as the first region of interest; the dose target of the second target region is the same as the second region of interest.
In particular, the dose targets of the first and second target regions are set as the first and second dose targets, i.e. the dose target of each voxel point within the first and second target regions is set to a unique value, which has the advantage that the dose target assignment of the voxel points of the overlap region of the regions of interest is automatically handled without manually setting the stand-off distance of the first dose target in the first dose volume target of the first region of interest to the dose target corresponding to the overlap region. Meanwhile, the requirement of radiotherapy is to enable the dose deposition in the ray target area region to reach the requirement of the prescription dose as much as possible, and simultaneously reduce the dose deposition to normal tissues around the target area region as much as possible.
The method comprises the steps of receiving an image of a target object, wherein the image comprises a first region of interest and a second region of interest, and the first region of interest and the second region of interest are overlapped to form an overlapping area; dividing the overlapping region according to a first dose target of the first region of interest and a second dose target of the second region of interest to determine a first target region and a second target region; the dose targets of the first target region and the second target region are set according to the first dose target and the second dose target, so that the problem that the dose distribution generated in the target region and the organ protection overlapping region has great uncertainty when the setting of a transition organ or an optimization parameter is unreasonable is solved, the radiotherapy plan design with organ overlapping can be processed more conveniently and intuitively by a user, the efficiency and plan quality of the TPS used by the user are improved, the ideal dose result of the target region and the voxel belonging area of the overlapping region under the condition of the given dose target of the protection organ can be visually seen in real time when the constraint condition of the protection organ is set by the user, and the uncertainty judgment of the final result of the radiotherapy plan by the user is reduced.
Example two
Fig. 3 is a flowchart of steps configured by a processor in a system for processing an overlapping area of a region of interest according to a second embodiment of the present invention. The present embodiment is optimized based on the above embodiment, and in the present embodiment, the processor may be further configured to: dividing the overlap region according to a first dose volume target of the first region of interest and a second dose volume target of the second region of interest to determine a third target region, the first target region and the second target region together constituting the overlap region; setting a dose target for the third target region according to the first dose volume target and the second dose volume target.
Accordingly, the processor of the present embodiment may be configured to:
s210, receiving an image of a target object, wherein the image comprises a first region of interest and a second region of interest, and the first region of interest and the second region of interest are overlapped to form an overlapping region.
S220, dividing the overlapping region according to the first dose volume target of the first region of interest and the second dose volume target of the second region of interest to determine a first target region, a second target region and a third target region.
And the third target area is a dose buffer area formed between the first target area and the second target area after the second target area is determined, and the voxel point in the third target area does not belong to the first interested area or the second interested area.
In particular, a second target region is determined in the overlap region based on a volume target of a second dose volume target of the second region of interest; determining a third target region from the first dose target of the first region of interest and the second dose target of the second region of interest; and taking the area of the overlapping area from which the second target area and the third target area are removed as the first target area. Wherein determining a third target region from the first dose volume target of the first region of interest and the second dose volume target of the second region of interest comprises: determining a dose buffer distance from a first dose volume target of the first region of interest and a second dose volume target of the second region of interest, the dose buffer distance being a distance required to change from a second one of the second dose volume targets to a first one of the first dose volume targets; and determining a third target area in the overlapping area according to the distance. Alternatively, the dose buffer distance may be the shortest distance from the first dose target to the second dose target.
Exemplarily, as shown in fig. 4, which is a schematic diagram of forming a third target region after dividing an overlap region of a region of interest according to an embodiment of the present invention, the overlap region 30 determines a second target region 50 according to a volume target in a second dose volume target of the second region of interest, forms a third target region 60 after the second target region 50 is generated, and uses a region of the overlap region 30 excluding the second target region 50 and the third target region 60 as the first target region 40. The third target region 60 is determined for the dose buffer region based on the dose buffer distance, i.e. the distance required for a change from a first one of the first dose volume targets to a second one of the second dose volume targets, from which the third target region 60 in the overlap region 30 can be automatically generated.
S230, setting the dose targets of the first target region, the second target region and the third target region according to the first dose volume target and the second dose volume target.
Specifically, the dose target of the first target region is the same as the first region of interest; the dose target of the second target region is the same as the second region of interest; the dose target of the third target region varies between the first dose target and the second dose target. And determining the dose target of each voxel in the third target region according to the dose target of the first target region, the dose target of the second target region and the distance from each voxel point to the remaining region of the second region of interest after the first target region and the third target region are removed.
Illustratively, assume that the Dose volume of the first region of interest A is targeted to a DoseTargetThe occupied Volume percentage is not less than VolumeTargetThe Dose volume of the second region of interest B is targeted as the DoseOARThe Volume percentage is not more than VolumeOARAnd | X | represents the number of voxel points in the arbitrary region X.
Second target areaThe voxel points in the domain are determined by the volume targets in the dose volume targets of the second region of interest, which can be expressed in particular by the following formula: wherein B denotes a second region of interest, C denotes an overlap region, and D denotes a second target region; when | B |. VolumeOARWhen the absolute value of D is less than or equal to absolute value of B-C, the absolute value of D is 0; when | B |. VolumeOARWhen | B-C |, the voxel points in the overlap region closer to the voxel points in the second region of interest will be preferentially classified to the second target region until the formula | D | + | B-C | ═ B | > Volume is satisfiedOAR. Further, it is understood that the voxel points of the third target region are determined by the dose target in the dose volume target of the second region of interest. For example: first, a given dose buffer distance is DistBufferThe distance being defined by the DoseTargetFall to DoseOARDetermining the required shortest distance; then, the shortest distance from each voxel point in the remaining region (i.e., region C-D) of the second target region D in the overlap region C to any voxel point in the combined region (i.e., region B-A + D) of the remaining region of the second region of interest B in which the first region of interest A is removed and the second target region D is smaller than DistBufferIs classified as a voxel point in the third target region. And taking the residual area of the overlapping area C from which the second target area D and the third target area are removed as the first target area.
In the optimization of the radiation treatment plan, it is also necessary to set dose targets for each region. Illustratively, the Dose target for each voxel point in the first target region is still set according to the Dose target for the first region of interest, i.e. the DoseTarget. The maximum Dose per voxel point in the second target region is set as the Dose target Dose for the second region of interestOAR. The dose target of the third target area is determined according to the dose target of the first target area, the dose target of the second target area and the distance from each voxel point to the remaining area of the second interest area after the first target area and the third target area are removed. For example, each voxel point in the third target region is removed from the second region of interestThe shortest distance between voxel points in the remaining area after the first target area and the third target area is DistE'Then the maximum Dose per voxel point in the third target region is set to DoseE'＝f(DoseTarget,DoseOAR,DistE') Wherein f is the domain in the interval [0, Dist ]Buffer]Inner, value range is [ DoseOAR,DoseTarget]Monotonically increasing function of inner, further, dose buffer distance DistBufferThe setting of the dose objective function f of the voxel points in the third target region may be implemented by automatic algorithm setting, manual user setting, or modeling from the dose distribution of the existing radiotherapy plan by a machine learning method, which is not limited in this embodiment of the present invention.
On the basis of the foregoing embodiment 1 and/or embodiment 2, the processor may further perform the following steps:
s240, displaying the first region of interest, the second region of interest, the first target region and the second target region, and the volume information corresponding to the regions.
Specifically, a human-computer interaction display interface for processing the overlapping region of the region of interest can be set in the radiation treatment planning system, and the human-computer interaction display interface includes two aspects: the display of auxiliary information in the overlapping area and the customization and display of the boundary of the overlapping area.
Assuming that the overlapping area is divided into a first target area and a second target area, in such a case, the auxiliary information may include: absolute volume of the overlap region; the volume of the overlap region is a percentage of the total volume of the first region of interest, i.e. overlap region/first region of interest 100%; the volume of the overlap region is a percentage of the total volume of the second region of interest, i.e. overlap region/second region of interest 100%; the volume of the second region of interest minus the volume within the overlap region classified as the first region of interest as a percentage of the total volume of the second region of interest, i.e., (second region of interest-first target region)/second region of interest 100%; the volume of the first region of interest minus the volume within the overlap region classified as the second region of interest as a percentage of the total volume of the first region of interest, i.e. (first region of interest-second target region)/first region of interest 100%. The display of the auxiliary information is used for helping a user to know the distribution of the overlapping area in the current state between the first region of interest and the second region of interest, and the user can conveniently design an objective function and estimate a dosage result.
If the overlap area is divided into a first target area, a second target area and a third target area. Then, the auxiliary information may include an absolute volume of the overlapping area; the volume of the overlap region is a percentage of the total volume of the first region of interest, i.e. overlap region/first region of interest 100%; the volume of the overlap region is a percentage of the total volume of the second region of interest, i.e. overlap region/second region of interest 100%; the volume of the second region of interest minus the volume of the overlap region divided into non-second regions of interest as a percentage of the total volume of the second region of interest, i.e., (second region of interest-first target region-third target region)/second region of interest 100%; the volume within the volume-minus-overlap region of the first region of interest is classified as a volume not belonging to the first region of interest as a percentage of the total volume of the first region of interest, i.e., (first region of interest-second target region-third target region)/first region of interest 100%.
And customizing and displaying a boundary of the overlapping region, wherein the boundary is used for indicating the volumes respectively belonging to the first region of interest and the second region of interest in the overlapping region during optimization of the radiation treatment plan, the final dose volume histogram and the evaluation index still adopt the original volumes of the first region of interest and the second region of interest, and the dragging of the boundary can be used for simultaneously modifying all layers, modifying a single layer or modifying constraint conditions in a linkage manner. The demarcation line was operated in the following manner: modifying at least one of the first dose target, the second dose target, the first target region and the second target region, and updating volume information corresponding to each region; or determining whether the first dose volume target and the second dose volume target reach a preset dose volume target, and modifying the volume information corresponding to each region. That is, the user automatically determines the position of the dividing line by adjusting the dose-volume constraint condition of the second region of interest, and updates the display of the auxiliary information; the user can modify the position of the boundary line on all CT layers of the overlapped area or a certain specified CT layer at the same time by drawing a window and using the boundary line dragging or self-defining volume input function, and update the display of the auxiliary information in real time; when the user modifies the position of the boundary line in a certain way, the software calculates and feeds back whether the dosage targets of the first region of interest and the second region of interest can reach the dosage target preset by the user or not.
According to the technical scheme provided by the embodiment of the invention, when radiotherapy plan optimization is carried out in a radiotherapy planning system, the condition of the overlapping region of the region of interest is processed, a user does not need to manually set the distance between the regions of interest, the user only needs to adjust the dose-volume target of the region of interest, the algorithm can automatically process the voxel allocation of the overlapping part of the region of interest and other regions of interest, a unique dose target of each voxel is provided for the overlapping region of the region of interest, and the optimization algorithm can search the optimal point more easily. Meanwhile, a user interaction mode is provided, and the aim of helping a user to design the voxel attribution in the overlapping region of the region of interest before optimization begins is achieved, and the effect of final dose distribution can be fully estimated. The main characteristics and advantages of the man-machine interaction mode setting include: displaying more comprehensive information, wherein the absolute volume of the overlapping region of the region of interest, the percentage of the overlapping region volume of the region of interest in the total volume of the region of interest respectively, and the percentage of the region of interest after the overlapping region of the region of interest is removed respectively in the total volume of the region of interest; the user does not need to manually or automatically generate a transition organ for optimizing the objective function, customizes the boundary of the interested region in the overlapping region of the interested region, and updates the information in real time. When the constraint condition of the region of interest is set by the user, the voxel of the overlapping region of the region of interest and the ideal dose result of the region of interest under the condition of giving the dose-volume target of the region of interest can be intuitively seen in real time, and the uncertainty judgment of the final result of the radiotherapy optimization plan by the user is reduced.
EXAMPLE III
Fig. 5 is a structural diagram of an apparatus for processing an overlapping region of a region of interest according to a third embodiment of the present invention, where the apparatus is configured in a processor, and the processor is configured in a system for processing an overlapping region of a region of interest according to any of the above embodiments, and then the apparatus may be used to execute steps configured by the processor in the system for processing an overlapping region of a region of interest. The apparatus and the system for processing the overlapping region of the region of interest of the embodiments belong to the same inventive concept, and details that are not described in detail in the embodiment of the apparatus for processing the overlapping region of the region of interest may refer to the embodiment of the system for processing the overlapping region of the region of interest. The present embodiment is applicable to the case where the overlapping region of the region of interest is treated in radiotherapy planning optimization, which may cause uncertainty of the dose result of the overlapping region because the voxel point is limited by two types of constraints.
As shown in fig. 5, the apparatus includes: an image receiving module 310, a target area determination module 320, and a dose target determination module 330, wherein:
an image receiving module 310, configured to receive an image of a target object, where the image includes a first region of interest and a second region of interest, and the first region of interest and the second region of interest overlap with each other to form an overlapping region;
a target region determining module 320, configured to determine a first target region and a second target region by dividing the overlap region according to a first dose volume target of the first region of interest and a second dose volume target of the second region of interest;
a dose target determination module 330 for setting the dose targets of the first target region and the second target region according to the first dose volume target and the second dose volume target.
The device for processing the overlapping region of the regions of interest of the embodiment receives an image of a target object, wherein the image comprises a first region of interest and a second region of interest, and the first region of interest and the second region of interest are overlapped with each other to form the overlapping region; dividing the overlapping region according to a first dose volume target of the first region of interest and a second dose volume target of the second region of interest to determine a first target region and a second target region; the dose targets of the first target region and the second target region are set according to the first dose volume target and the second dose volume target, so that the problem that the dose distribution generated in the target region and the organ protection overlapping region has great uncertainty when a transition organ or an optimization parameter is set unreasonably is solved, the radiotherapy plan design with organ overlapping can be processed more conveniently and intuitively by a user, the efficiency and plan quality of the TPS used by the user are improved, the ideal dose result of the voxel belonging of the overlapping region and the target region under the condition of giving the dose target of the protection organ can be visually seen in real time when the constraint condition of the protection organ is set by the user, and the uncertainty judgment of the final result of the radiotherapy plan by the user is reduced.
On the basis of the above embodiments, the apparatus further includes:
a third target region determining module, configured to determine a third target region by dividing the overlap region according to the first dose volume target of the first region of interest and the second dose volume target of the second region of interest, where the third target region, the first target region, and the second target region together form the overlap region;
setting a dose target for the third target region according to the first dose volume target and the second dose volume target.
On the basis of the above embodiments, the apparatus further includes:
and displaying the first region of interest, the second region of interest, the first target region and the second target region, and the volume information corresponding to each region.
On the basis of the above embodiments, the apparatus further includes:
and modifying at least one of the first dose volume target, the second dose volume target, the first target region and the second target region, and updating the volume information corresponding to each region.
On the basis of the above embodiments, the apparatus further includes:
and judging whether the first region of interest reaches the first dose volume target and/or whether the second region of interest reaches the second dose volume target according to the updated volume information.
On the basis of the foregoing embodiments, the target area determining module 320 is specifically configured to:
determining a second target region in the overlap region according to a second dose volume target of the second region of interest, and taking a region of the overlap region from which the second target region is removed as the first target region.
On the basis of the above embodiments, the apparatus further includes:
determining a second target region in the overlap region from a second dose volume target of the second region of interest;
determining a third target region from the first dose volume target of the first region of interest and the second dose volume target of the second region of interest;
and taking the area of the overlapping area from which the second target area and the third target area are removed as the first target area.
On the basis of the above embodiments, determining a third target region according to the first dose target of the first region of interest and the second dose target of the second region of interest includes:
determining a dose buffer distance from a first dose volume target of the first region of interest and a second dose volume target of the second region of interest, the dose buffer distance being a distance required to change from a second one of the second dose volume targets to a first one of the first dose volume targets;
and determining a third target area in the overlapping area according to the distance.
On the basis of the above embodiments, the dose target of the first target region is the same as the first region of interest; the dose target of the second target region is the same as the second region of interest.
On the basis of the above embodiments, the dose target of the first target region is the same as the first region of interest; the dose target of the second target region is the same as the second region of interest; the dose target of the third target region varies between the first dose target and the second dose target.
On the basis of the above embodiments, the dose target of each voxel in the third target region is determined according to the dose target of the first target region, the dose target of the second target region, and the distance from each voxel point to the remaining region of the second region of interest after the first target region and the third target region are removed.
On the basis of the above embodiments, the first region of interest is a target region and the second region of interest is a protected organ region.
The device for processing the overlapping region of the region of interest provided by each of the above embodiments may perform the steps configured by the processor in the system for processing the overlapping region of the region of interest provided by any embodiment of the present invention, and has functional modules and beneficial effects corresponding to the steps configured by the processor in the system for processing the overlapping region of the region of interest.
It is to be noted that the foregoing is only illustrative of the preferred embodiments of the present invention and the technical principles employed. It will be understood by those skilled in the art that the present invention is not limited to the particular embodiments described herein, but is capable of various obvious changes, rearrangements and substitutions as will now become apparent to those skilled in the art without departing from the scope of the invention. Therefore, although the present invention has been described in greater detail by the above embodiments, the present invention is not limited to the above embodiments, and may include other equivalent embodiments without departing from the spirit of the present invention, and the scope of the present invention is determined by the scope of the appended claims.

Claims (13)

1. A system for processing overlapping regions of a region of interest, comprising a memory, a processor, and a computer program stored on the memory and executable on the processor, comprising:
the processor implements the following steps when executing the program:
receiving an image of a target object, wherein the image comprises a first region of interest and a second region of interest, and the first region of interest and the second region of interest are overlapped with each other to form an overlapping region;
dividing the overlapping region according to a first dose volume target of the first region of interest and a second dose volume target of the second region of interest to determine a first target region and a second target region;
setting the dose objectives of the first and second target regions in accordance with the first and second dose volume objectives.
2. The system of claim 1, wherein the processor, when executing the program, further performs the steps of:
dividing the overlap region according to a first dose volume target of the first region of interest and a second dose volume target of the second region of interest to determine a third target region, the first target region and the second target region together constituting the overlap region;
setting a dose target for the third target region according to the first dose volume target and the second dose volume target.
3. The system of claim 1 or 2, wherein the processor, when executing the program, further performs the steps of:
and displaying the first region of interest, the second region of interest, the first target region and the second target region, and the volume information corresponding to each region.
4. The system of claim 3, wherein the processor, when executing the program, further performs the steps of:
and modifying at least one of the first dose volume target, the second dose volume target, the first target region and the second target region, and updating the volume information corresponding to each region.
5. The system of claim 4, wherein the processor, when executing the program, further performs the steps of:
and judging whether the first region of interest reaches the first dose volume target and/or whether the second region of interest reaches the second dose volume target according to the updated volume information.
6. The system of claim 1, wherein dividing the overlap region according to a first dose volume target for the first region of interest and a second dose volume target for the second region of interest determines a first target region and a second target region, comprising:
determining a second target region in the overlap region according to a second dose volume target of the second region of interest, and taking a region of the overlap region from which the second target region is removed as the first target region.
7. The system of claim 2, wherein dividing the overlap region according to a first dose volume target of the first region of interest and a second dose volume target of the second region of interest determines a third target region, the first target region, and the second target region collectively comprising the overlap region, comprises:
determining a second target region in the overlap region from a second dose volume target of the second region of interest;
determining a third target region from the first dose volume target of the first region of interest and the second dose volume target of the second region of interest;
and taking the area of the overlapping area from which the second target area and the third target area are removed as the first target area.
8. The system of claim 7, wherein determining a third target region from the first dose volume target for the first region of interest and the second dose volume target for the second region of interest comprises:
determining a dose buffer distance from a first dose volume target of the first region of interest and a second dose volume target of the second region of interest, the dose buffer distance being a distance required to change from a second one of the second dose volume targets to a first one of the first dose volume targets;
and determining a third target area in the overlapping area according to the distance.
9. The system of claim 1, wherein the dose target of the first target region is the same as the first region of interest; the dose target of the second target region is the same as the second region of interest.
10. The system of claim 8, wherein the dose target of the first target region is the same as the first region of interest; the dose target of the second target region is the same as the second region of interest; the dose target of the third target region varies between the first dose target and the second dose target.
11. The system of claim 10, wherein the dose target for each voxel in the third target region is determined based on the dose target of the first target region, the dose target of the second target region, and the distance from each voxel point to the remaining region of the second region of interest after the first target region and the third target region are removed.
12. The system of claim 1, wherein the first region of interest is a target region and the second region of interest is a protected organ region.
13. An apparatus for processing overlapping regions of a region of interest, the apparatus configured in a processor, the apparatus comprising:
the image receiving module is used for receiving an image of a target object, wherein the image comprises a first region of interest and a second region of interest, and the first region of interest and the second region of interest are overlapped with each other to form an overlapping region;
a target region determination module, configured to determine a first target region and a second target region by dividing the overlap region according to a first dose volume target of the first region of interest and a second dose volume target of the second region of interest;
a dose target determination module to set dose targets for the first target region and the second target region according to the first dose volume target and the second dose volume target.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111986254A (en) * 2020-08-21 2020-11-24 四川大学华西医院 Target area contour analysis method and device, storage medium and electronic equipment
CN112149669A (en) * 2020-09-23 2020-12-29 上海联影医疗科技股份有限公司 Radiotherapy plan generation system, radiotherapy plan generation device and storage medium

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070188624A1 (en) * 2006-02-13 2007-08-16 Benq Corporation Image capturing method and image-capturing device thereof
CN101422372A (en) * 2000-02-18 2009-05-06 威廉博蒙特医院 Cone-beam computerized tomography with a flat-panel imager
EP2293842A1 (en) * 2008-05-02 2011-03-16 Civatech Oncology Brachytherapy devices and related methods and computer program products
US20130217948A1 (en) * 2012-02-16 2013-08-22 Rhode Island Hospital Advanced Radiotherapy Treatment Planning Optimization
WO2014167461A1 (en) * 2013-04-11 2014-10-16 Koninklijke Philips N.V. Isodose optimization
CN105031819A (en) * 2015-08-25 2015-11-11 上海联影医疗科技有限公司 Dosage optimization method and system
US20170178349A1 (en) * 2015-12-18 2017-06-22 The Johns Hopkins University Method for deformable 3d-2d registration using multiple locally rigid registrations
EP3306335A1 (en) * 2016-10-07 2018-04-11 Ion Beam Applications S.A. Apparatus and method for localizing the bragg peak of a hadron beam traversing a target tissue by magnetic resonance imaging
US20180315188A1 (en) * 2017-04-21 2018-11-01 General Electric Company Automated organ risk segmentation machine learning methods and systems
US20190087688A1 (en) * 2017-09-19 2019-03-21 Taipei Veterans General Hospital Magnetic resonance image analysis method and method for evaluating the risks of radiotherapy
CN109982748A (en) * 2016-09-22 2019-07-05 瓦里安医疗系统国际股份公司 Dosage of the control except therapeutic targets is distributed and makes the dosage distribution forming in external beam radiation therapy
CN110420396A (en) * 2019-07-11 2019-11-08 上海联影医疗科技有限公司 A kind of radiotherapy treatment planning optimization system, device and storage medium

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101422372A (en) * 2000-02-18 2009-05-06 威廉博蒙特医院 Cone-beam computerized tomography with a flat-panel imager
US20070188624A1 (en) * 2006-02-13 2007-08-16 Benq Corporation Image capturing method and image-capturing device thereof
EP2293842A1 (en) * 2008-05-02 2011-03-16 Civatech Oncology Brachytherapy devices and related methods and computer program products
US20130217948A1 (en) * 2012-02-16 2013-08-22 Rhode Island Hospital Advanced Radiotherapy Treatment Planning Optimization
WO2014167461A1 (en) * 2013-04-11 2014-10-16 Koninklijke Philips N.V. Isodose optimization
CN105031819A (en) * 2015-08-25 2015-11-11 上海联影医疗科技有限公司 Dosage optimization method and system
US20170178349A1 (en) * 2015-12-18 2017-06-22 The Johns Hopkins University Method for deformable 3d-2d registration using multiple locally rigid registrations
CN109982748A (en) * 2016-09-22 2019-07-05 瓦里安医疗系统国际股份公司 Dosage of the control except therapeutic targets is distributed and makes the dosage distribution forming in external beam radiation therapy
EP3306335A1 (en) * 2016-10-07 2018-04-11 Ion Beam Applications S.A. Apparatus and method for localizing the bragg peak of a hadron beam traversing a target tissue by magnetic resonance imaging
US20180315188A1 (en) * 2017-04-21 2018-11-01 General Electric Company Automated organ risk segmentation machine learning methods and systems
US20190087688A1 (en) * 2017-09-19 2019-03-21 Taipei Veterans General Hospital Magnetic resonance image analysis method and method for evaluating the risks of radiotherapy
CN110420396A (en) * 2019-07-11 2019-11-08 上海联影医疗科技有限公司 A kind of radiotherapy treatment planning optimization system, device and storage medium

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111986254A (en) * 2020-08-21 2020-11-24 四川大学华西医院 Target area contour analysis method and device, storage medium and electronic equipment
CN112149669A (en) * 2020-09-23 2020-12-29 上海联影医疗科技股份有限公司 Radiotherapy plan generation system, radiotherapy plan generation device and storage medium
CN112149669B (en) * 2020-09-23 2023-05-23 上海联影医疗科技股份有限公司 Radiotherapy plan generation system, radiotherapy plan generation device and storage medium

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