CN110882087A - Inhalation amount monitoring device and system for inhalation exposure system - Google Patents
Inhalation amount monitoring device and system for inhalation exposure system Download PDFInfo
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- CN110882087A CN110882087A CN201911350016.4A CN201911350016A CN110882087A CN 110882087 A CN110882087 A CN 110882087A CN 201911350016 A CN201911350016 A CN 201911350016A CN 110882087 A CN110882087 A CN 110882087A
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- 238000012806 monitoring device Methods 0.000 title claims abstract description 24
- 231100000824 inhalation exposure Toxicity 0.000 title claims abstract description 17
- 241001465754 Metazoa Species 0.000 claims abstract description 32
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 238000012545 processing Methods 0.000 claims description 24
- 230000000241 respiratory effect Effects 0.000 claims description 15
- 238000009423 ventilation Methods 0.000 claims description 8
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 7
- 238000012544 monitoring process Methods 0.000 claims description 4
- 230000036387 respiratory rate Effects 0.000 claims description 3
- 238000001595 flow curve Methods 0.000 claims description 2
- 239000007789 gas Substances 0.000 abstract description 20
- 238000000034 method Methods 0.000 abstract description 9
- 238000010171 animal model Methods 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 230000037396 body weight Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 238000004891 communication Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 241000208125 Nicotiana Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000036391 respiratory frequency Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 238000000196 viscometry Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F22/00—Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The present invention relates to an inhalation amount monitoring device and system for an inhalation exposure system, wherein the monitoring device comprises: the passage pipe is used for accommodating animals, the tail part of the passage pipe is provided with a through hole, the side surface close to the tail part of the passage pipe is provided with a vent hole, and the front part of the passage pipe is communicated with first equipment for supplying gas to be inhaled; the adjusting rod penetrates through the through hole and is sealed with the through hole, a pressure plate for propelling the animal to move forwards is arranged at one end inside the channel pipe, a handle module is arranged at one end outside the channel pipe, and a gap for gas flowing is reserved between the pressure plate and the channel pipe; the silica gel ring is arranged at the position close to the front part of the channel tube and is used for dividing the inner cavity of the channel tube into two parts of which the gases are not communicated with each other when the animal passes through the silica gel ring; and the flow sensor is arranged in the vent hole and used for measuring the gas flow flowing from the channel pipe to the outside. Compared with the prior art, the invention can more accurately reflect the actual inhaled air quantity of animals in the experimental process, thereby ensuring that the experimental data of the inhaled dose is more accurate.
Description
Technical Field
The present invention relates to a module of an inhalation exposure system, and more particularly, to an inhalation amount monitoring apparatus and system for an inhalation exposure system.
Background
An inhalation exposure system is a laboratory device used for inhalation drug administration or inhalation toxicology studies. The respiratory system is the main way for oxygen to enter the human body, and drugs or toxic substances can also enter the human body through the respiratory system. The inhalation exposure system is used for enabling experimental animals to inhale medicines or toxic substances in a controllable mode under laboratory conditions, and researching the aspects of medicine safety, effectiveness or toxicological action and the like.
In exposure experiments, the inhaled (or administered) dose is an important data and the dose needs to be calculated from the volume of breath of the animal. At present, the respiratory volume data of animals are estimated according to body weight, and the common estimation method is as follows:
RMV(L/min)＝0.608·BW(kg)0.852
wherein: RMV (respiratory Minute volume) is the animal's breath volume per Minute, BW (BodyWeight) is the body weight of the experimental animal.
Although the above method has achieved good results in the fields of tobacco and the like, and is feasible in most of the time, with the evolution of medical technology, the situation that the metering research of the medicine is more and more accurate may face inaccurate problems, mainly that the breath of the animal is easily affected by the surrounding environment and the physiological state of the animal during the experiment, so the method has the main defect that the estimated data and the actual inhaled quantity generally have larger deviation.
Disclosure of Invention
It is an object of the present invention to overcome the above-mentioned drawbacks of the prior art by providing an inhalation amount monitoring device and system for an inhalation exposure system.
The purpose of the invention can be realized by the following technical scheme:
an inhalation volume monitoring device for an inhalation exposure system, comprising:
the passage pipe is used for accommodating animals, the tail part of the passage pipe is provided with a through hole, the side surface close to the tail part of the passage pipe is provided with a vent hole, and the front part of the passage pipe is communicated with first equipment for supplying gas to be inhaled;
the adjusting rod penetrates through the through hole and is sealed with the through hole, a pressure plate for propelling the animal to move forwards is arranged at one end inside the channel pipe, a handle module is arranged at one end outside the channel pipe, and a gap for gas flowing is reserved between the pressure plate and the channel pipe;
the silica gel ring is arranged at the position close to the front part of the channel tube and is used for dividing the inner cavity of the channel tube into two parts of which the gases are not communicated with each other when the animal passes through the silica gel ring;
and the flow sensor is arranged in the vent hole and used for measuring the gas flow flowing from the channel pipe to the outside.
The channel pipe comprises a pipe main body and an end cover which are detachably connected, the through hole is formed in the end cover, the vent hole is formed in the side face of the end cover or the side face of the pipe main body, and the pipe main body and the end cover are sealed when connected.
The vent hole is arranged on the side surface of the tube main body.
The flow sensor is a differential pressure type micro-flow sensor.
The differential pressure type micro-flow sensor comprises a porous laminar flow device and a differential pressure sensor, wherein two air holes for measuring differential pressure are formed in the side face of the porous laminar flow device, and a plurality of ventilation channels which are arranged along the axial direction are formed in the part between the two air holes.
The porous laminar flow device has the function of enabling the airflow flowing through the air holes to conform to the laminar flow characteristic, namely the Reynolds number is less than 2000.
The junction of the front portion of the passage pipe and the first device is sealed.
A monitoring system comprising the monitoring device comprises the monitoring device and a control processing device, wherein the control processing device is connected with a flow sensor in the monitoring device and used for obtaining a real-time respiratory flow curve according to the measured gas flow and further obtaining characteristic data of animal respiration at least comprising respiratory rate, tidal volume and minute ventilation.
The control processing device comprises a computer and a data acquisition and processing unit, wherein one end of the data acquisition and processing unit is connected with the flow sensor, and the other end of the data acquisition and processing unit is connected with the computer.
The data acquisition and processing unit is connected with the computer in a USB, network or WIFI mode.
Compared with the prior art, the invention has the following beneficial effects:
1) through the sealed, through-hole department of silica gel circle sealed, the unsealed design of pressure disk department for the space of channel pipe rear end forms a cavity that only the air vent was as the export, and the enlargement of thing thorax is directly embodied in this cavity, can obtain more accurate suction volume and measure.
2) By designing a special differential pressure type micro-flow sensor and enabling the Reynolds number to be less than 2000, the requirement of laminar flow can be met, and accurate flow measurement can be obtained.
Drawings
FIG. 1 is a schematic view of a monitoring device according to the present invention;
FIG. 2 is a schematic side view of a porous flow cell;
FIG. 3 is a schematic front view of a porous flow device;
wherein: 1. the device comprises a channel pipe, 2, an adjusting rod, 3, a first device, 4, a silica gel ring, 5, a porous layer flow device, 11, a vent hole, 12, a pipe main body, 13, an end cover, 21, a pressure plate, 51, an air hole, 52 and a vent channel.
Detailed Description
The invention is described in detail below with reference to the figures and specific embodiments. The present embodiment is implemented on the premise of the technical solution of the present invention, and a detailed implementation manner and a specific operation process are given, but the scope of the present invention is not limited to the following embodiments.
An inhalation volume monitoring device for an inhalation exposure system, as shown in fig. 1, comprising:
the device comprises a channel pipe 1, a first device 3 and a second device 3, wherein the channel pipe 1 is used for accommodating animals, the tail part of the channel pipe is provided with a through hole, the side surface close to the tail part of the channel pipe is provided with a vent hole 11, the front part of the channel pipe is communicated with the first device 3 for supplying gas to be inhaled, and the joint of the front part of the channel pipe 1 and the first;
the adjusting rod 2 penetrates through the through hole and is sealed with the through hole, a pressure plate 21 for propelling the animal to move forwards is arranged at one end inside the channel pipe 1, a handle module is arranged at one end outside the channel pipe 1, and a gap for gas flowing is reserved between the pressure plate 21 and the channel pipe 1;
the silicone ring 4 is arranged at the position close to the front part of the channel tube 1 and is used for dividing the inner cavity of the channel tube 1 into two parts with non-intercommunicated gas when the animal passes through the silicone ring;
and a flow sensor provided in the vent hole 11 for measuring the flow rate of the gas flowing from the passage tube 1 to the outside. The flow sensor is a differential pressure type micro-flow sensor.
The channel tube 1 comprises a tube main body 12 and an end cover 13 which are detachably connected, a through hole is formed in the end cover 13, a vent hole 11 is formed in the side face of the end cover 13 or the side face of the tube main body 12, and the tube main body 12 and the end cover 13 are sealed when connected. Preferably, the vent hole 11 is provided in a side surface of the tube main body 12.
Because the position of animal neck has increased silica gel circle 4, has designed a pore diameter 5 ~ 10 mm's air vent 11 at the channel pipe 1 rear end simultaneously, embeds a differential micro-flow sensor. After the animal is pushed to the most front position by using the adjusting rod 2, the silicone ring 4 forms a basically sealed structure at the position of the neck of the animal. The neck seal allows the animal body to be in a chamber having only one ventilation path for the differential pressure microfluidic sensor. According to this design, the fluctuation of the thoracoabdominal region of the animal during respiration pushes an almost equal amount of gas through the differential pressure type micro-flow sensor, so that the instantaneous gas flow here can be used to represent the animal's oronasal breathing gas flow.
The differential pressure type micro flow sensor includes a porous laminar flow 5 and a differential pressure sensor, as shown in fig. 2 and 3, the side of the porous laminar flow 5 is provided with two air holes 51 for measuring differential pressure, and a portion between the two air holes 51 is provided with a plurality of ventilation channels 52 arranged in the axial direction.
In a short section of piping, if the gas flow is in laminar flow, the gas pressure differential is proportional to the flow rate, as follows:
wherein: Δ P is the pressure differential, μ is the Dynamic Viscosity of air (Dynamic viscometry), L is the length of the conduit, D is the diameter of the conduit, Q is the flow rate, and π is the circumference ratio.
The method of measuring differential pressure can thus be used to calculate the gas flow: after the standard flowmeter is used for calibrating the coefficients of the differential pressure and the flow, the animal respiratory flow data can be obtained by measuring the differential pressure, and the differential pressure type micro-flow sensor is formed.
However, since the linear relationship must be established under laminar flow conditions, a laminar flow device is required to ensure that the flow in the measurement section is in laminar flow conditions during normal respiration of the animal. The condition of meeting the laminar flow characteristic is that the Reynolds number is less than 2000, and the Reynolds number is calculated according to the following formula:
wherein: re is Reynolds number, D is pore diameter, V is air flow rate, ρ is air density, and μ is dynamic viscosity of air. From the above formula, in order to ensure that the reynolds number is less than 2000, the laminar flow device should be designed to be a porous structure so as to reduce the diameter of a single hole, thereby reducing the reynolds number.
Therefore, the length of the porous flow restrictor, the number of pores, and the pore diameter are designed according to the size of the respiratory flow, the measurement range of the differential pressure sensor, and the condition that the reynolds number is less than 2000.
For a certain kind of experimental animal, it is generally possible to obtain an approximate range of its respiratory flow from past experimental data. Differential pressure sensors are typically selected to have as small a range as possible (e.g., a 125Pa differential pressure sensor) to minimize the effect of the sensor on animal respiration and improve measurement accuracy.
The porous laminar flow devices are equivalent to porous parallel connection, the pressure difference is equal, and the flow rates are added.
From the above, the design steps of the length of the laminar flow device, the number of air holes and the aperture are summarized:
1. according to the type of the experimental animal, the tidal volume data are consulted and obtained, and the approximate range of the respiratory flow is calculated and determined.
2. According to the flow range, the length, the number of air holes and the aperture of the laminar flow device are designed to be proper, so that the differential pressure of the laminar flow device in the respiratory flow range basically matches with the measurement range of the differential pressure sensor.
3. The number and the aperture of the air holes are adjusted, so that the respiratory airflow accords with the laminar flow characteristic when passing through the laminar flow device, namely the Reynolds number is less than 2000.
The respiratory flow monitoring system for the inhalation exposure system is designed by utilizing the monitoring device, and comprises the monitoring device and a control processing device, wherein the control processing device is connected with a flow sensor in the monitoring device and is used for obtaining a respiratory flow real-time curve according to the measured gas flow and further obtaining characteristic data of animal respiration at least comprising respiratory rate, tidal volume and minute ventilation volume.
The control processing device comprises a computer and a data acquisition and processing unit, one end of the data acquisition and processing unit is connected with the flow sensor, the other end of the data acquisition and processing unit is connected with the computer, and the computer is loaded with corresponding software. The data acquisition and processing unit is connected with the computer in a USB, network or WIFI mode.
The data acquisition and processing unit is a circuit module for data acquisition and processing. The method comprises the steps of firstly, rapidly and continuously collecting pressure difference data, converting the pressure difference data into respiratory flow according to a calibration coefficient of a pressure difference type micro-flow sensor, and then analyzing and calculating a respiratory flow real-time curve to obtain respiratory characteristic data of experimental animals such as respiratory frequency, tidal volume, minute ventilation volume and the like.
The software runs on an upper computer, provides an operation interface for a user, and displays animal inhalation volume characteristic data in the inhalation exposure experiment process. Data communication can be realized between the upper computer running the interface software and the data acquisition and processing unit in a USB (universal serial bus), network or WIFI (wireless fidelity) mode. The interface software acquires the inhalation amount data from the data acquisition and processing unit by a certain standard or self-defined communication protocol, and displays the data to the user in the form of a curve and a data table. Meanwhile, historical data is stored in a database for a user to view and further process.
Claims (10)
1. An inhalation volume monitoring device for an inhalation exposure system, comprising:
the passage pipe (1) is used for accommodating animals, the tail part of the passage pipe is provided with a through hole, the side surface close to the tail part is provided with a vent hole (11), and the front part of the passage pipe is communicated with a first device (3) for supplying gas to be inhaled;
the adjusting rod (2) penetrates through the through hole and is sealed with the through hole, a pressure plate (21) for propelling the animal to move forwards is arranged at one end inside the channel pipe (1), a handle module is arranged at one end outside the channel pipe (1), and a gap for gas flowing is reserved between the pressure plate (21) and the channel pipe (1);
the silica gel ring (4) is arranged at the position close to the front part of the channel tube (1) and is used for dividing the inner cavity of the channel tube (1) into two parts with non-intercommunicated gas when an animal passes through the silica gel ring;
and the flow sensor is arranged in the vent hole (11) and used for measuring the gas flow flowing from the channel pipe (1) to the outside.
2. A suction volume monitoring device for a suction exposure system according to claim 1, wherein the passage tube (1) comprises a tube body (12) and an end cap (13) which are detachably connected, the through hole is provided in the end cap (13), the vent hole (11) is provided in a side surface of the end cap (13) or a side surface of the tube body (12), and the tube body (12) and the end cap (13) are sealed when they are connected.
3. A suction volume monitoring device for a suction exposure system according to claim 2, wherein the vent (11) is provided at a side of the tube body (12).
4. The inhalation monitoring device of claim 1, wherein the flow sensor is a differential pressure type micro-flow sensor.
5. The suction amount monitoring device for a suction exposure system according to claim 4, wherein the differential pressure type micro flow sensor comprises a porous laminar flow (5) and a differential pressure sensor, the side of the porous laminar flow (5) is provided with two air holes (51) for measuring a differential pressure, and a portion between the two air holes (51) is provided with a plurality of axially arranged ventilation channels (52).
6. An inhalation exposure system according to claim 5 wherein the porous laminar flow (5) is such that the flow of air through the air holes (11) as the animal breathes conforms to laminar flow characteristics, i.e. reynolds number less than 2000.
7. An inhalation exposure system according to claim 1, wherein the connection between the front of the passage tube (1) and the first device (3) is sealed.
8. A monitoring system comprising the monitoring device according to any one of claims 1 to 7, characterized by comprising the monitoring device and a control processing device, wherein the control processing device is connected with a flow sensor in the monitoring device and is used for obtaining a real-time respiratory flow curve according to the measured gas flow and further obtaining characteristic data of animal respiration at least comprising respiratory rate, tidal volume and minute ventilation.
9. An inhalation amount monitoring device for an inhalation exposure system according to claim 8, wherein said control processing means comprises a computer and a data acquisition and processing unit, one end of said data acquisition and processing unit being connected to the flow sensor and the other end thereof being connected to the computer.
10. An inhalation volume monitoring device for an inhalation exposure system according to claim 9, wherein said data acquisition and processing unit is connected to a computer by means of USB, network or WIFI.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911350016.4A CN110882087A (en) | 2019-12-24 | 2019-12-24 | Inhalation amount monitoring device and system for inhalation exposure system |
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| CN201911350016.4A CN110882087A (en) | 2019-12-24 | 2019-12-24 | Inhalation amount monitoring device and system for inhalation exposure system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116058999A (en) * | 2023-03-29 | 2023-05-05 | 四川大学 | Quantitative and accurate anesthetic method and device for experimental animal gas |
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| US20110000482A1 (en) * | 2009-07-01 | 2011-01-06 | Anand Gumaste | Laboratory animal pulmonary dosing device |
| US20110218450A1 (en) * | 2010-03-02 | 2011-09-08 | Haefner Paul A | Respiration Measurements and Dosimetry Control in Inhalation Testing Systems |
| CN211797040U (en) * | 2019-12-24 | 2020-10-30 | 上海瑞曼信息科技有限公司 | Inhalation amount monitoring device for inhalation exposure system |
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2019
- 2019-12-24 CN CN201911350016.4A patent/CN110882087A/en active Pending
Patent Citations (7)
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|---|---|---|---|---|
| GB2077444A (en) * | 1980-06-06 | 1981-12-16 | Draegerwerk Ag | Determining at least two parameters of a patient's respiratory system |
| US6601460B1 (en) * | 1998-06-10 | 2003-08-05 | Peter Albert Materna | Flowmeter based on pressure drop across parallel geometry using boundary layer flow including Reynolds numbers above the laminar range |
| US20020103443A1 (en) * | 2001-01-31 | 2002-08-01 | Roy Chad J. | Automated inhalation toxicology exposure system |
| JP2007232453A (en) * | 2006-02-28 | 2007-09-13 | Sumitomo Chemical Co Ltd | Inhalation toxicity tester and inhalation toxicity testing method |
| US20110000482A1 (en) * | 2009-07-01 | 2011-01-06 | Anand Gumaste | Laboratory animal pulmonary dosing device |
| US20110218450A1 (en) * | 2010-03-02 | 2011-09-08 | Haefner Paul A | Respiration Measurements and Dosimetry Control in Inhalation Testing Systems |
| CN211797040U (en) * | 2019-12-24 | 2020-10-30 | 上海瑞曼信息科技有限公司 | Inhalation amount monitoring device for inhalation exposure system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116058999A (en) * | 2023-03-29 | 2023-05-05 | 四川大学 | Quantitative and accurate anesthetic method and device for experimental animal gas |
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