CN110828278B - Positive and negative ion simultaneous measurement two-dimensional separation ion migration tube - Google Patents
Positive and negative ion simultaneous measurement two-dimensional separation ion migration tube Download PDFInfo
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- CN110828278B CN110828278B CN201911117806.8A CN201911117806A CN110828278B CN 110828278 B CN110828278 B CN 110828278B CN 201911117806 A CN201911117806 A CN 201911117806A CN 110828278 B CN110828278 B CN 110828278B
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0095—Particular arrangements for generating, introducing or analyzing both positive and negative analyte ions
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
Abstract
The invention discloses an ion migration tube based on two-dimensional orthogonal combination of an asymmetric field ion mobility spectrometry and a migration time ion mobility spectrometry, and particularly relates to an ion migration tube simultaneously comprising an asymmetric field ion separation channel and a migration time ion separation channel. The ion separation device is characterized in that the asymmetric field ion separation channel and the migration time ion separation channel are coaxially arranged, the asymmetric field ion separation channel is composed of two coaxially arranged separation electrodes, and an ion outlet is positioned on the axis of the migration time ion separation channel; the asymmetric field ion separation channel simultaneously carries out first-dimension separation and focusing on positive and negative ions generated by an ionization source, and then efficiently transmits the positive and negative ions to the axis of the migration time ion separation channel; and electric fields in the migration time ion separation channel are periodically switched, so that the second-dimensional separation and simultaneous detection of positive and negative ions are realized. The ion migration tube can realize high-sensitivity two-dimensional orthogonal separation detection, and has high target identification accuracy and strong field applicability.
Description
Technical Field
The invention discloses a two-dimensional separation ion migration tube for simultaneous measurement of positive ions and negative ions. In particular to an ion migration tube which realizes the simultaneous detection of positive ions and negative ions and the two-dimensional orthogonal separation by utilizing the orthogonal combination of an asymmetric field ion mobility spectrometry and a migration time ion mobility spectrometry and the rapid switching of the polarity of a separation electric field in the migration time ion mobility spectrometry.
Background
Ion Mobility Spectrometry (IMS) is a gas-phase ion separation detection technology that emerged in the early 70 s of the 20 th century. Compared with mass spectrometry, the ion resolution of the IMS is weak. However, IMS has the advantages of high sensitivity, operation at atmospheric pressure, portability of instruments, and the like. At present, the IMS plays a role of a mainstream technology in the national and public safety fields such as explosive and drug field screening, and the like, and also plays an increasingly important role in field rapid detection in the fields of environmental pollution, food safety and biomedical research by combining the IMS with gas chromatography and liquid chromatography.
The IMS can be classified into a migration time ion mobility spectrum (DTIMS), an asymmetric field ion mobility spectrum (FAIMS/DMS), a differential mobility ion mobility spectrum (DMA), an inhalational ion mobility spectrum (AIMS), and the like according to an ion mobility separation method. Among them, the DTIMS performs ion separation analysis by using a difference in time required for different ions to pass through the same distance in a uniform direct current weak electric field (E/N <4Td, E represents an electric field strength, and N represents a molecular number density of a gas), and is the most widely used IMS technique. Compared with mass spectra, chromatograms and the like, the resolution capability of IMS technology is generally low, for example, DTIMS is generally between 40 and 50, FAIMS is between 10 and 20, and DMA is between 10 and 20. The single IMS technology is often difficult to meet the resolution requirements for rapid in-situ detection of complex samples. Therefore, a two-dimensional or even three-dimensional coupling system based on the IMS technology is constructed, the adaptability of the instrument to field detection is kept, and meanwhile, high resolution capability and peak capacity are obtained, and the method is an important direction for the research of the IMS technology.
FAIMS is a technology for realizing the simultaneous separation and detection of positive and negative ions by applying a high-frequency asymmetric electric field between parallel sheet-shaped separation polar plates or between coaxial cylindrical separation polar plates, and the FAIMS adopting the coaxial separation polar plates also has the functions of ion space focusing and high-efficiency transmission. Shvartsburg et al (US7170053) and Guevremont et al (US7368709) divide an ion separation polar plate of FAIMS into a plurality of sections of electrodes, apply a high-frequency asymmetric electric field between the separation polar plates, and simultaneously introduce a direct-current weak electric field along the axial direction of a polar plate gap, so that the two-dimensional orthogonal combination of FAIMS and DTIMS is realized. However, the design can not meet the characteristic that the DTIMS has high requirement on the uniformity of the direct-current weak electric field, the resolution capability is improved to a limited extent, and only unipolar ions can be detected.
The dual-DTIMS separation channel is placed on two sides of the FAIMS ion detection polar plate by the company of Sinonex (Proc. of SPIE,2008,6954,69540H), so that the positive and negative ions under two-dimensional orthogonal separation are simultaneously detected. In the design, the extraction efficiency of ions between the FAIMS parallel separation polar plates into the DTIMS is low, so that the system sensitivity is poor; in addition, the voltage on the DTIMS needs to be applied reversely, the ion receiving electrode is at a high level, and the signal extraction is difficult.
Bohnhorst et al (anal. chem.2018,90,1114) also combine DMS with DTIMS and improve system resolution by embedding voltage-modulated three-parallel grid electrodes in the DTIMS's migration tube. However, this design does not have two-dimensional orthogonal separation characteristics and can only detect unipolar ions.
The invention discloses an ion migration tube design based on the combination of FAIMS and DTIMS. The ion migration tube has a simple structure, comprises a FAIMS separation channel and a DTIMS separation channel, and can realize simultaneous measurement of positive and negative ions under two-dimensional orthogonal separation; in addition, the FAIMS separation channel can synchronously carry out ion separation and ion focusing and efficiently transmit the ions to the DTIMS separation channel, and the system sensitivity is high.
The invention content is as follows:
the invention aims to construct a two-dimensional ion mobility separation analysis system capable of simultaneously detecting positive ions and negative ions, so that high peak capacity and resolution capability are obtained on one hand, and panoramic ion information of a target object is obtained on the other hand, and accurate identification of the target object in a complex matrix is realized.
In order to achieve the purpose, the invention adopts the technical scheme that:
a positive and negative ion simultaneous measurement two-dimensional separation ion migration tube comprises an ion source, an asymmetric field ion separation channel, a migration time ion separation channel and an ion receiving electrode which are sequentially arranged from left to right;
the asymmetric field ion separation channel is composed of a cylindrical outer separation electrode and a cylindrical inner separation electrode which are mutually spaced and coaxially arranged; the cylindrical outer separating electrode is a cylindrical barrel with an opening at the left end and a closed right end, the right bottom surface inside the barrel is hemispherical, the hemispherical bottom surface is coaxial with the barrel, and a through hole serving as an ion outlet is formed in the hemispherical bottom surface along the axis direction; the columnar inner separation electrode is a circular column, the right end face of the column is hemispherical, and the hemispherical end face is coaxial with the column; the inner separation electrode is arranged inside the outer separation electrode to form a gap surrounding the axis of the electrode for one circle;
arranging an insulating sealing cylinder at the left end of the asymmetric field ion separation channel, wherein the insulating sealing cylinder is coaxial with the asymmetric field ion separation channel; a circular groove is formed in the right end face of the insulating sealing cylinder along the axis direction, the right end face of the insulating sealing cylinder is hermetically connected with the left end face of the outer separation electrode, and the circular groove is communicated with a gap between the inner separation electrode and the outer separation electrode; an ion source is arranged on the side wall of the insulating and sealing cylinder, and an opening of the ion source points to the inside of the cylinder and is communicated with the annular groove; a through hole communicated with the annular groove is arranged on the left end face of the insulating sealing cylinder and is used as a carrier gas inlet;
the migration time ion separation channel is a hollow cylinder body formed by coaxially and alternately superposing annular electrodes and annular insulators, the migration time ion separation channel is coaxial with the asymmetric field ion separation channel, the left end of the migration time ion separation channel is in insulation and sealing connection with the right end of the outer separation electrode through the annular insulators, and an ion outlet of the outer separation electrode is communicated with an inner cavity of the migration time ion separation channel;
the ion receiving electrode contains a Faraday disc for receiving ions, the ion receiving electrode is in insulation sealing connection with the right end of the migration time ion separation channel through an annular insulator, and the ion receiving electrode, the Faraday disc and the migration time ion separation channel are coaxial; forming an axial through hole on the ion receiving electrode as a floating gas inlet;
an ion gate capable of controlling the on-off of ions is arranged between the asymmetric field ion separation channel and the ion receiving electrode, the ion gate divides the migration time ion separation channel into an ion buffer area and an ion migration area, and the ion gate is coaxial with the migration time ion separation channel; a through hole is formed in the side wall of the ion buffer area and serves as an air outlet;
the external separation electrode and the ion receiving electrode are respectively connected with a first voltage and the ground, and each electrode of the migration time ion separation channel is connected with the external separation electrode and the ion receiving electrode through a voltage dividing resistance chain; the first voltage is square wave voltage with adjustable period and 50% duty ratio, the polarities of the high and low levels of the square wave voltage are opposite, and the absolute values of the voltages are the same;
applying a second voltage to the inner separation electrode, wherein the second voltage consists of a high-frequency asymmetric separation voltage and a direct-current compensation scanning voltage, and the voltages of the outer separation electrodes of the second voltage are used as reference voltages (or bias voltages);
the period time of the first square wave voltage is the same as the voltage step maintaining time of the direct current compensation scanning voltage in the second voltage.
The ion source is any ion source capable of generating ions.
The ion gate is a three-parallel grid ion gate, and the parallel grid is a metal mesh grid or a metal wire grid which can penetrate ions.
The carrier gas inlet, the floating gas inlet and the gas outlet are more than 2 and are axially and uniformly distributed along the ion migration tube.
The carrier gas carrying the sample to be detected enters the ion migration tube through the carrier gas inlet, and is ionized by the ion source to generate positive and negative sample ions; sample ions are carried by carrier gas to enter an asymmetric field ion separation channel, are separated and enriched under the action of a high-frequency asymmetric separation electric field and a direct-current compensation scanning electric field, and then enter an ion buffer area through an ion outlet; under the action of periodically changing electric fields in the migration time ion separation channel, positive and negative sample ions in the ion buffer area respectively enter the ion migration area through the ion gate opened by pulse, are separated under the drive of the separation electric field, and are received and converted into positive and negative ion spectrogram information of current intensity to time by the Faraday disc to be output.
When the process is carried out, one path of floating gas enters the migration time ion separation channel from a floating gas inlet arranged on the ion receiving electrode and flows along the direction opposite to the flight direction of ions, and finally flows out of the ion migration tube from a gas outlet arranged on the ion buffer area together with the carrier gas.
The gas is O2、N2、CO2、H2And Ar, or a mixture of two or more gases.
The invention has the advantages that:
firstly, a direct serial connection mode is adopted between a FAIMS separation channel and a DTIMS separation channel in the ion migration tube, and a complex interface device is not needed; secondly, only one DTIMS separation channel is used in combination with the FAIMS separation channel, so that the simultaneous detection of positive and negative ions can be realized under two-dimensional orthogonal separation, the migration tube structure is simple, and the field detection applicability is strong; and thirdly, the FAIMS separation channel adopting the coaxial separation polar plate can synchronously carry out ion separation and ion focusing, and efficiently transmits ions to the DTIMS separation channel, so that the system sensitivity is high.
The invention is described in further detail below with reference to the accompanying drawings:
description of the drawings:
fig. 1 is a schematic diagram of an ion mobility tube structure based on a combination of asymmetric field ion mobility spectrometry and migration time ion mobility spectrometry. Wherein: (1) the ion source comprises a VUV light ionization source, an asymmetric field ion separation channel, a migration time ion separation channel, an ion receiving electrode, a Faraday disc, a tetrafluoro cylinder, a carrier gas inlet, a floating gas inlet, a gas outlet, a stainless steel ring, a tetrafluoro ring, a outer separation electrode, an inner separation electrode, a carrier gas inlet, a floating gas inlet, a gas outlet, a stainless steel ring, a tetrafluoro ring, a tetrafluoride ring, a separation electrode (21), an ion buffer area, a three-parallel grid ion gate and an ion migration area (33).
FIG. 2 is a waveform of a first voltage applied to a transit time ion separation channel; wherein the absolute values of the voltages of V (+) and V (-) are the same, V (+) is regulated between 5000 and 10000V, V (-) is regulated between-5000 and-10000V, and the period of the first square wave voltage is 10 ms.
FIG. 3 is a schematic diagram of a three parallel gate ion gate structure and gate control voltage waveforms; the opening time w of the ion door can be adjusted by adjusting the time difference between t1 and t2gThe ion gate duty cycle is 5 ms.
The specific implementation mode is as follows:
example 1
An ion mobility tube based on two-dimensional orthogonal combination of asymmetric field ion mobility spectrometry and migration time ion mobility spectrometry is shown in figure 1. The ion migration tube comprises a VUV light ionization source (1), an asymmetric field ion separation channel (2), a migration time ion separation channel (3) and an ion receiving electrode (4) which are sequentially arranged from left to right;
the asymmetric field ion separation channel (2) is composed of a cylindrical outer separation electrode (21) and a cylindrical inner separation electrode (22) which are coaxially arranged; the outer separation electrode (21) is a cylindrical barrel (length is 32mm, outer diameter is 40mm, inner diameter is 30mm, cylindrical cavity area length is 15mm) with an opening at the left end and a closed right end, the right bottom surface inside the barrel is hemispherical (spherical radius is 15mm), the hemispherical bottom surface is coaxial with the barrel, and a through hole (aperture is 2mm) serving as an ion outlet (23) is formed in the hemispherical bottom surface along the axial direction; the columnar inner separation electrode (22) is a circular column (with the length of 29mm, the outer diameter of 28mm and the length of a cylindrical area of 15mm), the right end face of the column is hemispherical (with the spherical radius of 14mm), and the hemispherical end face is coaxial with the column; the inner separation electrode (22) is arranged inside the outer separation electrode (21) to form a gap (the radial width is 1mm) which surrounds the axis of the electrode for one circle;
a tetrafluoro column (6) with the outer diameter of 40mm and the length of 20mm is arranged at the left end of the asymmetric field ion separation channel (2), and the tetrafluoro column (6) is coaxial with the asymmetric field ion separation channel (2); an annular groove with the depth of 15mm (the groove is 30mm large and the groove is 28mm small) is formed in the right end face of the tetrafluoro cylinder (6) along the axis direction, and the right end face of the tetrafluoro cylinder (6) is hermetically connected with the left end face of the outer separation electrode (21); 2 VUV light ionization sources (1) which are uniformly distributed on the circumference are arranged on the side wall of the tetrafluoro cylinder (6), and the openings of the ionization sources point to the inside of the cylinder and are communicated with the annular groove; through holes (the hole diameter is 1mm) communicated with the circular groove are formed in the left end face of the tetrafluoro cylinder (6) and are used as carrier gas inlets (7), and the number of the carrier gas inlets (7) is 2, and the carrier gas inlets are uniformly distributed along the circumference;
the migration time ion separation channel (3) is formed by coaxially and alternately superposing a stainless steel ring (10) with the outer diameter of 40mm, the thickness of 1mm and the inner diameter of 30mm and a tetrafluoro ring (11) with the outer diameter of 40mm, the thickness of 4mm and the inner diameter of 30mm, and the total length is 87 mm; the left end of the migration time ion separation channel (3) is connected with the right end of an outer separation electrode (21) in an insulating and sealing way through a tetrafluoride ring (11);
the three-parallel grid ion gate (32) is formed by coaxially and alternately superposing three stainless steel grid meshes with the outer diameter of 40mm and the thickness of 50 mu m and two tetrafluoride rings with the outer diameter of 40mm, the inner diameter of 30mm and the thickness of 1mm, as shown in figure 3; the ion gate (32) divides the migration time ion separation channel (3) into an ion buffer area (31) with the length of 15mm and an ion migration area (33) with the length of 70mm, through holes with the diameter of 1mm are formed in the side wall of the ion buffer area (31) and serve as air outlets (9), and the number of the air outlets (9) is 2, and the air outlets are uniformly distributed along the circumference;
the ion receiving electrode (4) is 40mm in outer diameter and 10mm in thickness, a Faraday disc (5) with the diameter of 8mm is embedded inside the ion receiving electrode, the ion receiving electrode (4) is connected with the right end of the migration time ion separation channel (3) in an insulating and sealing mode through a tetrafluoride ring (11), and the ion receiving electrode (4), the Faraday disc (5) and the migration time ion separation channel (3) are coaxial; through holes with the diameter of 1mm are axially formed in the ion receiving electrode (4) and are used as floating gas inlets (8), and the number of the floating gas inlets (8) is 2, and the floating gas inlets are uniformly distributed along the circumference;
the external separation electrode (21) and the ion receiving electrode (4) are respectively connected with a first square wave voltage with a period of 10ms and the ground, all electrodes of the migration time ion separation channel (3) are connected with the external separation electrode (21) and the ion receiving electrode (4) in series through a voltage dividing resistor chain (1M omega resistor) end to end, and a uniform migration electric field with polarity period change is formed in the migration time ion separation channel (3); the waveform of the first square wave voltage is as shown in fig. 2;
a second voltage is applied to the inner separation electrode (22), the second voltage consists of a high-frequency asymmetric separation voltage and a direct-current compensation scanning voltage, the voltages of the outer separation electrode (21) are used as reference voltages (or bias voltages) to form a high-frequency asymmetric separation electric field and a direct-current compensation scanning electric field between the inner separation electrode (22) and the outer separation electrode (21); parameters of the asymmetric separation voltage in the second voltage are as follows: the frequency is 2MHz, the high voltage amplitude is 1000V, and the parameters of the DC compensation scanning voltage are as follows: the voltage step is 0.2V, the voltage step maintaining time is 10ms, and the scanning voltage range is the reference voltage value +/-30V;
when the ion migration tube works, carrier gas (clean air) carrying a sample to be detected enters the ion migration tube through a carrier gas inlet (7), and is ionized by an ion source (1) to generate positive and negative sample ions; sample ions are carried by carrier gas to enter the asymmetric field ion separation channel (2), are separated and enriched under the action of a high-frequency asymmetric separation electric field and a direct-current compensation scanning electric field, and then enter an ion buffer area (31) through an ion outlet (23); under the action of a periodically changing electric field in an ion separation channel (3) during migration time, positive and negative sample ions in the ion buffer area (31) respectively enter an ion migration area (33) through three parallel grid ion gates (32) which are opened in a pulse mode, are separated under the driving of the separation electric field and are received and converted into positive and negative ion spectrogram information of current intensity versus time by a Faraday disc (5) to be output.
When the process is carried out, a path of floating gas (clean air) enters the interior of the ion separation channel (3) during migration from a floating gas inlet (8) arranged on the ion receiving electrode (4) and flows along the direction opposite to the flight direction of ions, and finally flows out of the ion migration tube from an air outlet (9) arranged on the ion buffer area (31) together with the carrier gas.
Claims (6)
1. A positive and negative ion simultaneous measurement two-dimensional separation ion migration tube comprises an ion source (1), an asymmetric field ion separation channel (2), a migration time ion separation channel (3) and an ion receiving electrode (4) which are sequentially arranged from left to right; the method is characterized in that:
the asymmetric field ion separation channel (2) is composed of a cylindrical outer separation electrode (21) and a cylindrical inner separation electrode (22) which are mutually spaced and coaxially arranged; the cylindrical outer separation electrode (21) is a cylindrical barrel with an opening at the left end and a closed right end, the right bottom surface inside the barrel is hemispherical, the hemispherical bottom surface is coaxial with the barrel, and a through hole serving as an ion outlet (23) is formed in the hemispherical bottom surface along the axis direction; the columnar inner separation electrode (22) is a circular column body, the right end face of the column body is hemispherical, and the hemispherical end face is coaxial with the column body; the inner separation electrode (22) is arranged inside the outer separation electrode (21) to form a gap which surrounds the axis of the electrode for one circle;
an insulating sealing cylinder (6) is arranged at the left end of the asymmetric field ion separation channel (2), and the insulating sealing cylinder (6) is coaxial with the asymmetric field ion separation channel (2); an annular groove is formed in the right end face of the insulating sealing cylinder (6) along the axis direction, the right end face of the insulating sealing cylinder (6) is hermetically connected with the left end face of the outer separation electrode (21), and the annular groove is communicated with a gap between the inner separation electrode (22) and the outer separation electrode (21); an ion source (1) is arranged on the side wall of the insulating sealing cylinder (6), and an opening of the ion source points to the inside of the cylinder and is communicated with the annular groove; a through hole communicated with the annular groove is arranged on the left end face of the insulating sealing cylinder (6) and is used as a carrier gas inlet (7);
the migration time ion separation channel (3) is a hollow cylinder formed by coaxially and alternately superposing annular electrodes (10) and annular insulators (11), the migration time ion separation channel (3) is coaxial with the asymmetric field ion separation channel (2), the left end of the migration time ion separation channel (3) is in insulation and sealing connection with the right end of an outer separation electrode (21) through the annular insulators (11), and an ion outlet (23) of the outer separation electrode (21) is communicated with the inner cavity of the migration time ion separation channel (3);
the ion receiving electrode (4) contains a Faraday disc (5) capable of receiving ions, the ion receiving electrode (4) is in insulation sealing connection with the right end of the migration time ion separation channel (3) through an annular insulator (11), and the ion receiving electrode (4), the Faraday disc (5) and the migration time ion separation channel (3) are coaxial; a through hole along the axial direction is arranged on the ion receiving electrode (4) and is used as a floating gas inlet (8);
an ion gate (32) capable of controlling the on-off of ions is arranged between the asymmetric field ion separation channel (2) and the ion receiving electrode (4), the ion gate (32) divides the migration time ion separation channel (3) into an ion buffer area (31) and an ion migration area (33), and the ion gate (32) and the migration time ion separation channel (3) are coaxial; a through hole is arranged on the side wall of the ion buffer area (31) and is used as an air outlet (9);
the external separation electrode (21) and the ion receiving electrode (4) are respectively connected with a first voltage and the ground, and each electrode of the migration time ion separation channel (3) is connected with the external separation electrode (21) and the ion receiving electrode (4) through a divider resistor chain; the first voltage is square wave voltage with adjustable period and 50% duty ratio, the polarities of the high and low levels of the square wave voltage are opposite, and the absolute values of the voltages are the same;
a second voltage is applied to the inner separation electrode (22), the second voltage consists of a high-frequency asymmetric separation voltage and a direct-current compensation scanning voltage, and the voltages of the outer separation electrodes (21) of the second voltage are used as reference voltages or bias voltages;
the period time of the first square wave voltage is the same as the voltage step maintaining time of the direct current compensation scanning voltage in the second voltage.
2. The ion transfer tube of claim 1, wherein: the ion source (1) is any ion source capable of generating ions.
3. The ion transfer tube of claim 1, wherein: the ion gate (32) is an ion gate with three parallel grids, and the parallel grids are metal grids or metal wire grids which can penetrate ions.
4. The ion transfer tube of claim 1, wherein: the carrier gas inlet (7), the floating gas inlet (8) and the gas outlet (9) are more than 2 and are axially and uniformly distributed along the ion migration tube.
5. An ion transfer tube according to any one of claims 1 to 4, wherein: the carrier gas carrying the sample to be detected enters the ion migration tube through the carrier gas inlet (7), and is ionized by the ion source (1) to generate positive and negative sample ions; sample ions are carried by carrier gas to enter the asymmetric field ion separation channel (2), are separated and enriched under the action of a high-frequency asymmetric separation electric field and a direct-current compensation scanning electric field, and then enter an ion buffer area (31) through an ion outlet (23); under the action of a periodically changing electric field in an ion separation channel (3) during migration time, positive and negative sample ions in the ion buffer area (31) respectively enter an ion migration area (33) through an ion gate (32) opened by pulses, are separated under the drive of the separation electric field and are received and converted into spectrogram information of current intensity to time by a Faraday disc (5) to be output;
when the process is carried out, one path of floating gas enters the ion separation channel (3) in the migration time from a floating gas inlet (8) arranged on the ion receiving electrode (4) and flows along the direction opposite to the flight direction of ions, and finally flows out of the ion migration tube from a gas outlet (9) arranged on the ion buffer area (31) together with the carrier gas.
6. The ion transfer tube of claim 5, wherein: the gas is O2、N2、CO2、H2Ar, or a mixture of two or more thereofA compound (I) is provided.
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