CN110812699A - Remote defibrillation protection system and control method thereof - Google Patents

Remote defibrillation protection system and control method thereof Download PDF

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CN110812699A
CN110812699A CN201911221420.1A CN201911221420A CN110812699A CN 110812699 A CN110812699 A CN 110812699A CN 201911221420 A CN201911221420 A CN 201911221420A CN 110812699 A CN110812699 A CN 110812699A
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defibrillation
ventricular fibrillation
control center
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data
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CN110812699B (en
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刘琦
谭家兴
王康
刘宇
刘颖
陈茂
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Sichuan University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/38Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
    • A61N1/39Heart defibrillators
    • A61N1/3904External heart defibrillators [EHD]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0004Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
    • A61B5/0006ECG or EEG signals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/318Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/318Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A61B5/346Analysis of electrocardiograms
    • A61B5/349Detecting specific parameters of the electrocardiograph cycle
    • A61B5/361Detecting fibrillation
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/04Architecture, e.g. interconnection topology
    • G06N3/044Recurrent networks, e.g. Hopfield networks
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/04Architecture, e.g. interconnection topology
    • G06N3/045Combinations of networks
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/08Learning methods
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

Abstract

The invention discloses a remote defibrillation protection system and a control method thereof, wherein the system comprises an acquisition module, a control module and a control module, wherein the acquisition module is used for acquiring pressure data, respiration data, apical pulsation data and electrocardiogram signals of a defibrillation electrode plate; when the control center is on line, transmitting the electrocardiogram signal to the cloud platform, receiving a prediction result from the cloud platform, and when the control center is off line, inputting the current electrocardiogram signal into a ventricular fibrillation prediction model to obtain a prediction result of whether ventricular fibrillation occurs; when the defibrillation electrode slice does not fall off, respiration does not exist, the apex of the heart does not beat and ventricular fibrillation occurs, sending a defibrillation instruction to the defibrillation module and sending a starting instruction to the prompt module; and the defibrillation module is used for receiving a command of manually cancelling defibrillation, and if the command of manually cancelling defibrillation is not received within a set time after the defibrillation command is received, defibrillation is executed.

Description

Remote defibrillation protection system and control method thereof
Technical Field
The invention relates to the field of medical treatment, in particular to a remote defibrillation protection system and a control method thereof.
Background
Cardiovascular disease is the disease with the highest global prevalence and mortality, and the vast majority of patients with cardiovascular disease die from cardiac arrest. Sudden cardiac arrest refers to sudden cardiac arrest, resulting in severe ischemia and hypoxia of vital organs (such as brain) and termination of life. The most effective treatment method of cardiac arrest is electrical defibrillation, and for cardiac arrest patients, effective electrical defibrillation is the only pre-hospital emergency treatment method which is effective in reducing the mortality of the patients within 3-5 minutes.
Disclosure of Invention
In view of the above-mentioned deficiencies in the prior art, the present invention aims to provide a remote defibrillation protection system and a control method thereof, which can improve the survival probability of patients with cardiac arrest.
In order to achieve the purpose of the invention, the invention adopts the technical scheme that:
a remote defibrillation protection system is provided, comprising:
the acquisition module is used for acquiring pressure data, respiration data, apical pulsation data and electrocardiogram signals of the defibrillation electrode slices and then transmitting the pressure data, the respiration data, the apical pulsation data and the electrocardiogram signals to the control center;
the control center is used for judging whether the defibrillation electrode plates fall off, whether respiration exists and whether apical pulsation exists according to the pressure data, the respiration data and the apical pulsation data of the defibrillation electrode plates respectively; when the control center is on-line, the electrocardiogram signals are transmitted to the cloud platform through the network, the prediction results from the cloud platform are received, and when the control center is off-line, the current electrocardiogram signals are input into ventricular fibrillation prediction models stored in the control center to obtain the prediction results of whether ventricular fibrillation occurs; when the defibrillation electrode slice does not fall off, respiration does not exist, the apex of the heart does not beat and ventricular fibrillation is predicted, sending a defibrillation instruction to the defibrillation module and sending a starting instruction to the prompt module;
the defibrillation module is used for receiving a command of manually cancelling defibrillation, and if the command of manually cancelling defibrillation is not received within a set time after the defibrillation command is received, defibrillation is executed;
the prompting module is used for receiving the starting instruction and then executing voice prompt to prompt other people not to touch the patient;
and the cloud platform is used for receiving and storing the electrocardiogram signals, inputting the current electrocardiogram signals into the ventricular fibrillation prediction model stored in the cloud platform to obtain a prediction result of whether ventricular fibrillation occurs, and if so, sending the prediction result to the control center.
Further, the ventricular fibrillation prediction model is obtained through a deep learning algorithm.
Further, the obtaining of the ventricular fibrillation prediction model by the deep learning algorithm further comprises:
acquiring a set number of electrocardiogram signals, and preprocessing the electrocardiogram signals to obtain a training set;
defining a grid parameter loss function and a cost matrix loss function of a CoSen-Bi-LSTM network model, inputting a training set into the constructed CoSen-Bi-LSTM network model for training to obtain a ventricular fibrillation prediction model, wherein the CoSen-Bi-LSTM network model comprises an input layer, a first hidden layer, a second hidden layer, an output layer and a cost sensitive layer which are sequentially connected.
Further, inputting the training set into the constructed CoSen-Bi-LSTM network model for training to obtain the ventricular fibrillation prediction model further comprises: the network is trained by adopting a random gradient descent method, gradient updating is carried out by adopting an SGD method, and the learning rate is 0.001.
Further, the grid parameters of the CoSen-Bi-LSTM network model are cross entropy loss functions.
Further, the preprocessing the training set to obtain the training set further comprises:
s1, cutting each electrocardiogram signal into a plurality of sub-electrocardiogram signals according to each 4 heartbeats in sequence;
s2, after correcting baseline drift of the sub-electrocardiogram signals by using a high-pass filter, removing high-frequency noise by using a contraction method based on wavelet transformation;
and S3, giving each sub-electrocardiogram signal class label to obtain a training set.
Further, the calculation formula of the system function of the high-pass filter is:
Figure BDA0002300968200000031
wherein z is a sub-electrocardiogram signal.
On the other hand, the scheme also provides a control method of the remote defibrillation protection system, which comprises the following steps:
the acquisition module acquires pressure data, respiration data, apical pulsation data and electrocardiogram signals of the defibrillation electrode slices and then sends the pressure data, the respiration data, the apical pulsation data and the electrocardiogram signals to the control center;
the control center judges whether the defibrillation electrode plate falls off, whether respiration exists and whether apical pulsation exists according to the pressure data, the respiration data and the apical pulsation data of the defibrillation electrode plate respectively;
when the control center is on line, the electrocardiogram signals are transmitted to the cloud platform through the network, the cloud platform receives and stores the electrocardiogram signals, the current electrocardiogram signals are input into ventricular fibrillation prediction models stored in the cloud platform to obtain prediction results of whether ventricular fibrillation occurs, and if yes, the prediction results are sent to the control center; when the control center is off-line, inputting the current electrocardiogram signal into a ventricular fibrillation prediction model stored in the control center to obtain a prediction result of whether ventricular fibrillation occurs;
when the defibrillation electrode slice does not fall off, respiration does not exist, the apex of the heart does not beat and ventricular fibrillation is predicted, the control center sends a defibrillation instruction to the defibrillation module and sends a starting instruction to the prompt module; the defibrillation module executes defibrillation if the defibrillation module does not receive a manual defibrillation cancelling instruction within a set time after receiving the defibrillation instruction; the prompting module receives the starting instruction and then executes voice prompt to prompt other people not to touch the patient.
The invention has the beneficial effects that: the accuracy of the sudden cardiac arrest judgment is enhanced by acquiring and judging whether respiration exists or not and whether apical pulsation exists or not and combining the ventricular fibrillation prediction model prediction result. The combination of the defibrillation module and the instruction for receiving the manual defibrillation cancellation reduces the probability of the defibrillation electrode misdischarge. Meanwhile, the effectiveness of electrical defibrillation is improved by collecting and judging whether the defibrillation electrode plate falls off or not. And the prompting module prompts people beside the defibrillator not to touch the patient before defibrillation, thereby ensuring the safety of people who contact the patient and simultaneously ensuring effective defibrillation.
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Fig. 1 is a schematic block diagram of the present invention.
Detailed Description
The following detailed description of the present invention will be provided in conjunction with the accompanying drawings to facilitate the understanding of the present invention by those skilled in the art. It should be understood that the embodiments described below are only some embodiments of the invention, and not all embodiments. All other embodiments obtained by a person skilled in the art without any inventive step, without departing from the spirit and scope of the present invention as defined and defined by the appended claims, fall within the scope of protection of the present invention.
As shown in fig. 1, the remote defibrillation-prevention system includes:
the acquisition module is used for acquiring pressure data, respiration data, apical pulsation data and electrocardiogram signals of the defibrillation electrode slices and then transmitting the pressure data, the respiration data, the apical pulsation data and the electrocardiogram signals to the control center;
the control center is used for judging whether the defibrillation electrode plates fall off, whether respiration exists and whether apical pulsation exists according to the pressure data, the respiration data and the apical pulsation data of the defibrillation electrode plates respectively; when the control center is on-line, the electrocardiogram signals are transmitted to the cloud platform through the network, the prediction results from the cloud platform are received, and when the control center is off-line, the current electrocardiogram signals are input into ventricular fibrillation prediction models stored in the control center to obtain the prediction results of whether ventricular fibrillation occurs; when the defibrillation electrode slice does not fall off, respiration does not exist, the apex of the heart does not beat and ventricular fibrillation is predicted, sending a defibrillation instruction to the defibrillation module and sending a starting instruction to the prompt module;
the defibrillation module is used for receiving a command of manually cancelling defibrillation, and if the command of manually cancelling defibrillation is not received within a set time after the defibrillation command is received, defibrillation is executed;
the prompting module is used for receiving the starting instruction and then executing voice prompt to prompt other people not to touch the patient;
and the cloud platform is used for receiving and storing the electrocardiogram signals, inputting the current electrocardiogram signals into the ventricular fibrillation prediction model stored in the cloud platform to obtain a prediction result of whether ventricular fibrillation occurs, and if so, sending the prediction result to the control center.
The acquisition module, the control center, the defibrillation module and the prompt module are all located on the wearable defibrillation device.
During implementation, the optimal control unit is connected with the mobile terminal (generally a mobile phone of a patient) through the Bluetooth module, and the electrocardiogram signal is sent to the cloud platform through the mobile terminal.
The ventricular fibrillation prediction model is obtained through a deep learning algorithm and further comprises the following steps:
(1) acquiring a set number of electrocardiogram signals, and preprocessing the electrocardiogram signals to obtain a training set:
s1, cutting each electrocardiogram signal into a plurality of sub-electrocardiogram signals according to each 4 heartbeats in sequence;
s2, after correcting baseline drift of the sub-electrocardiogram signals by using a high-pass filter, removing high-frequency noise by using a contraction method based on wavelet transformation; the system function of the high-pass filter is calculated as:
Figure BDA0002300968200000051
wherein z is a sub-electrocardiogram signal.
And S3, giving each sub-electrocardiogram signal label to obtain a training set, wherein the labels comprise atrial tachycardia, ventricular fibrillation, sinus arrhythmia, atrial tachycardia, atrial fibrillation, junction tachycardia, priming syndrome, atrioventricular block, ventricular block, pacemaker rhythm and normal rhythm.
(2) Defining a grid parameter loss function and a cost matrix loss function of a CoSen-Bi-LSTM network model, wherein the CoSen-Bi-LSTM network model comprises an input layer, a first hidden layer, a second hidden layer, an output layer and a cost sensitive layer which are sequentially connected, grid parameters are cross entropy loss functions, and the expression of the grid parameter loss functions is as follows:
Figure BDA0002300968200000052
wherein d isnIn order to be a real label, the label,
Figure BDA0002300968200000053
onand okAs output of the output layer, ynIs the output modified by the cost sensitive layer.
The expression of the cost matrix loss function is:
Figure BDA0002300968200000061
wherein E isvalTo verify the error, θ is the over-parameter of the network, ξ is the cost matrix,
Figure BDA0002300968200000062
μ1、μ2、σ1and σ2For cross-validation parameters, R is the confusion matrix for the current class error, S is the matrix for class-to-class separability, H is the matrix defined by the training set class distribution histogram vector H,
Figure BDA0002300968200000063
p is a class in c, q is a class in c, hpIs a histogram vector of class p, hqIs a histogram vector of class q, and c is the set of all classes of a given electrocardiogram data set.
And inputting the training set into the constructed CoSen-Bi-LSTM network model for training to obtain the ventricular fibrillation prediction model. Specifically, a network is trained by adopting a random gradient descent method, gradient updating is carried out by adopting an SGD method, and the learning rate is 0.001.
In the training process, calculating the input and the output of each layer of neurons, calculating the gradient of a grid parameter loss function and a cost matrix loss function according to the input and the output to perform back propagation, judging whether the value of the grid parameter loss function is smaller than a given error, if so, determining a ventricular fibrillation prediction model structure, if not, judging whether the training frequency reaches a given maximum iteration frequency, if so, determining the model structure, and if not, continuing the training.
On the other hand, the scheme also provides a control method of the remote defibrillation protection system, which comprises the following steps:
the acquisition module acquires pressure data, respiration data, apical pulsation data and electrocardiogram signals of the defibrillation electrode slices and then sends the pressure data, the respiration data, the apical pulsation data and the electrocardiogram signals to the control center;
the control center judges whether the defibrillation electrode plate falls off, whether respiration exists and whether apical pulsation exists according to the pressure data, the respiration data and the apical pulsation data of the defibrillation electrode plate respectively;
when the control center is on line, the electrocardiogram signals are transmitted to the cloud platform through the network, the cloud platform receives and stores the electrocardiogram signals, the current electrocardiogram signals are input into ventricular fibrillation prediction models stored in the cloud platform to obtain prediction results of whether ventricular fibrillation occurs, and if yes, the prediction results are sent to the control center; when the control center is off-line, inputting the current electrocardiogram signal into a ventricular fibrillation prediction model stored in the control center to obtain a prediction result of whether ventricular fibrillation occurs;
when the defibrillation electrode slice does not fall off, respiration does not exist, the apex of the heart does not beat and ventricular fibrillation is predicted, the control center sends a defibrillation instruction to the defibrillation module and sends a starting instruction to the prompt module; the defibrillation module executes defibrillation if the defibrillation module does not receive a manual defibrillation cancelling instruction within a set time after receiving the defibrillation instruction; the prompting module receives the starting instruction and then executes voice prompt to prompt other people not to touch the patient.

Claims (8)

1. A remote defibrillation protection system, comprising:
the acquisition module is used for acquiring pressure data, respiration data, apical pulsation data and electrocardiogram signals of the defibrillation electrode slices and then transmitting the pressure data, the respiration data, the apical pulsation data and the electrocardiogram signals to the control center;
the control center is used for judging whether the defibrillation electrode plates fall off, whether respiration exists and whether apical pulsation exists according to the pressure data, the respiration data and the apical pulsation data of the defibrillation electrode plates respectively; when the control center is on-line, the electrocardiogram signals are transmitted to the cloud platform through the network, the prediction results from the cloud platform are received, and when the control center is off-line, the current electrocardiogram signals are input into ventricular fibrillation prediction models stored in the control center to obtain the prediction results of whether ventricular fibrillation occurs; when the defibrillation electrode slice does not fall off, respiration does not exist, the apex of the heart does not beat and ventricular fibrillation is predicted, sending a defibrillation instruction to the defibrillation module and sending a starting instruction to the prompt module;
the defibrillation module is used for receiving a command of manually cancelling defibrillation, and if the command of manually cancelling defibrillation is not received within a set time after the defibrillation command is received, defibrillation is executed;
the prompting module is used for receiving the starting instruction and then executing voice prompt to prompt other people not to touch the patient;
and the cloud platform is used for receiving and storing the electrocardiogram signals, inputting the current electrocardiogram signals into the ventricular fibrillation prediction model stored in the cloud platform to obtain a prediction result of whether ventricular fibrillation occurs, and if yes, sending the prediction result to the control center.
2. The remote defibrillation protection system of claim 1, wherein the ventricular fibrillation prediction model is derived by a deep learning algorithm.
3. The remote defibrillation protection system of claim 2, wherein the ventricular fibrillation prediction model is derived by a deep learning algorithm further comprising:
acquiring a set number of electrocardiogram signals, and preprocessing the electrocardiogram signals to obtain a training set;
defining a grid parameter loss function and a cost matrix loss function of a CoSen-Bi-LSTM network model, inputting a training set into the constructed CoSen-Bi-LSTM network model for training to obtain a ventricular fibrillation prediction model, wherein the CoSen-Bi-LSTM network model comprises an input layer, a first hidden layer, a second hidden layer, an output layer and a cost sensitive layer which are sequentially connected.
4. The remote defibrillation protection system of claim 3, wherein the training set is input into the constructed CoSen-Bi-LSTM network model for training to obtain the ventricular fibrillation prediction model further comprises: the network is trained by adopting a random gradient descent method, gradient updating is carried out by adopting an SGD method, and the learning rate is 0.001.
5. The remote defibrillation protection system of claim 3, wherein the mesh parameters of the CoSen-Bi-LSTM network model are cross entropy loss functions.
6. The remote defibrillation protection system of claim 3, wherein preprocessing the same to obtain a training set further comprises:
s1, cutting each electrocardiogram signal into a plurality of sub-electrocardiogram signals according to each 4 heartbeats in sequence;
s2, after correcting baseline drift of the sub-electrocardiogram signals by using a high-pass filter, removing high-frequency noise by using a contraction method based on wavelet transformation;
and S3, giving each sub-electrocardiogram signal class label to obtain a training set.
7. The remote defibrillation protection system of claim 6, wherein the system function of the high pass filter is calculated by:
Figure FDA0002300968190000021
wherein z is a sub-electrocardiogram signal.
8. The method of controlling a remote defibrillation protection system of any one of claims 1 to 7, comprising:
the acquisition module acquires pressure data, respiration data, apical pulsation data and electrocardiogram signals of the defibrillation electrode slices and then sends the pressure data, the respiration data, the apical pulsation data and the electrocardiogram signals to the control center;
the control center judges whether the defibrillation electrode plate falls off, whether respiration exists and whether apical pulsation exists according to the pressure data, the respiration data and the apical pulsation data of the defibrillation electrode plate respectively;
when the control center is on line, transmitting an electrocardiogram signal to the cloud platform through a network, receiving and storing the electrocardiogram signal by the cloud platform, inputting the current electrocardiogram signal into the ventricular fibrillation prediction model stored in the cloud platform to obtain a prediction result of whether ventricular fibrillation occurs, and if yes, sending the prediction result to the control center; when the control center is off-line, inputting the current electrocardiogram signal into a ventricular fibrillation prediction model stored in the control center to obtain a prediction result of whether ventricular fibrillation occurs;
when the defibrillation electrode slice does not fall off, respiration does not exist, the apex of the heart does not beat and ventricular fibrillation is predicted, the control center sends a defibrillation instruction to the defibrillation module and sends a starting instruction to the prompt module; the defibrillation module executes defibrillation if the defibrillation module does not receive a manual defibrillation cancelling instruction within a set time after receiving the defibrillation instruction; the prompting module receives the starting instruction and then executes voice prompt to prompt other people not to touch the patient.
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