CN110811942A - Elastic biological ceramic support for spiral pipeline and preparation process thereof - Google Patents
Elastic biological ceramic support for spiral pipeline and preparation process thereof Download PDFInfo
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- CN110811942A CN110811942A CN201911032430.0A CN201911032430A CN110811942A CN 110811942 A CN110811942 A CN 110811942A CN 201911032430 A CN201911032430 A CN 201911032430A CN 110811942 A CN110811942 A CN 110811942A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/88—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
- A61F2/885—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils comprising a coil including a plurality of spiral or helical sections with alternate directions around a central axis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
A spiral pipeline elastic biological ceramic support and a preparation process thereof, wherein the support comprises more than two groups of horizontal assemblies arranged in the vertical direction, and two adjacent groups of horizontal assemblies are connected through a vertical support body for supporting; the horizontal assembly comprises more than two circular pipelines which are connected through more than two vortex pipelines; the vertical support body is composed of more than one layer of spiral pipelines from outside to inside; the spiral pipeline and the vortex pipeline enable the support to have certain elasticity in the longitudinal direction and the transverse direction, and the support has larger deformation.
Description
Technical Field
The invention belongs to the technical field of medical materials, and particularly relates to a spiral pipeline elastic biological ceramic support and a preparation process thereof.
Technical Field
With the development of science and technology, ceramics play an increasingly important role in the medical field, wherein bioceramics have excellent bioactivity and osteoinductivity and can well promote bone repair and growth, so that bioceramics scaffolds are increasingly researched and applied in orthopedics. However, the existing biological ceramic scaffold has the problems of high brittleness and no elasticity, and is very easy to generate brittle fracture.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide the spiral pipeline elastic biological ceramic support and the preparation process thereof, the support has small brittleness and good elasticity, and can be applied to the field of medical materials.
In order to achieve the purpose, the invention adopts the technical scheme that:
the utility model provides a spiral duct elasticity biological ceramic support, includes more than two sets of horizontal assembly 1 according to the vertical direction setting, and two sets of adjacent horizontal assembly 1 are connected through vertical support body 2 and are supported.
The horizontal assembly 1 comprises more than two circular pipelines 1-a, and the circular pipelines 1-a are connected through more than two vortex pipelines 1-b; the diameters of central circular lines of the circular ring pipelines of the same horizontal assembly 1 are different, and the sizes of the central circular lines are between 10mm and 30 mm; each vortex pipeline can be connected with all circular ring pipelines in the same horizontal assembly 1, the central vortex line pitches of the vortex pipelines in the same horizontal assembly 1 are the same, and the sizes of the vortex pipelines are 15 mm-55 mm.
The vertical support body 2 is composed of more than one layer of spiral pipelines 2-a from outside to inside, the number of the layers is the number of the circular pipelines in the horizontal assembly 1 minus 1, and the diameter of the central spiral line of each spiral pipeline is correspondingly equal to the diameter of the central line of the other circular pipelines except the smallest circular pipeline in the horizontal assembly 1; the central spiral lines of the spiral pipelines in different layers have different diameters, and the size of the central spiral lines is between 10mm and 30 mm; the screw pitches of the spiral pipelines in different layers are the same, and the screw pitches are between 4mm and 20 mm; the spiral pipeline of the same layer is composed of two spiral pipelines with different initial angles and the same other parameters, and the difference of the initial angles is 180 degrees.
The circular pipeline, the vortex pipeline and the spiral pipeline are hollow pipelines, the diameter of an outer circle of each hollow pipeline is between 2mm and 6mm, and the diameter of an inner circle of each hollow pipeline is between 0.5mm and 4 mm.
The circular pipeline, the vortex pipeline and the spiral pipeline are provided with holes with the diameter of 0.3 mm-3 mm on the surfaces, and degradable polymers are poured into the hollow pipeline through the holes, wherein the degradable polymers are polycaprolactone, polylactic acid or polylactic acid-polyglycolic acid.
The spiral pipeline is used as a spring model, the whole spiral pipeline elastic biological ceramic support is simplified into a series-parallel connection model of the spring, the stiffness coefficient of one spring model is derived from an energy equation, the work done by the spring by external force is all equal to the increment of the elastic potential energy of the spring, the acting force acting on the spring is F, the deformation of the spring is lambda, and then the spring has the advantages that
Wherein G is the shear modulus of the ceramic material; n-the effective number of turns of the ceramic spring; d, the pitch diameter of the ceramic spring; d2-the outer diameter of the tube of the ceramic spring; d1Inner diameter of the tube of the ceramic spring.
The ceramic of the spiral pipeline elastic biological ceramic support is made of one or a combination of more of tricalcium phosphate, calcium silicate, hydroxyapatite, zirconia, magnesia, alumina, silica and titanium dioxide according to the requirements of required rigidity, strength and elastic performance.
A preparation process of a spiral pipeline elastic biological ceramic support comprises the following steps:
1) model establishment and processing:
according to the implantation requirement of the biological ceramic support, the diameters of the outer circle and the inner circle of all pipelines of the elastic biological ceramic support of the spiral pipeline and the diameters of small holes on the pipelines are designed, the number of circular pipeline groups, the diameter of a central circular line of the circular pipeline, the number of vortex pipeline groups, the pitch of a central vortex line of the vortex pipeline, the number of spiral pipeline groups, the diameter of a central spiral line of the spiral pipeline and the pitch of the spiral line are designed; wherein the diameters of the outer circles of the circular pipeline, the vortex pipeline and the spiral pipeline are between 2mm and 6mm, the diameter of the inner circle is between 0.5mm and 4mm, and the diameter of the small hole is between 0.3mm and 3 mm; the number of the circular pipelines in the same horizontal assembly 1 is more than two, and the central circular lines of the internal circular pipelines have different diameters and the size is between 10mm and 30 mm; the number of the vortex pipelines in the same horizontal assembly 1 is two and above, the central vortex linear pitches of the inner vortex pipelines are the same, and the sizes of the inner vortex pipelines are between 15mm and 55 mm; the number of the spiral pipeline layers is that the number of the circular pipelines in one horizontal assembly 1 is reduced by 1, the diameter of the central spiral line of the spiral pipeline is correspondingly equal to the diameter of the central line of the other circular pipelines except the smallest circular pipeline in one horizontal assembly 1, the diameters of the central spiral lines of the spiral pipelines in different layers are different, and the size of the central spiral lines is 10-30 mm; the screw pitches of the spiral pipelines in different layers are the same, and the screw pitches are between 4mm and 20 mm; the same layer of spiral pipeline is composed of two spiral pipelines with different initial angles and the same other parameters, and the difference of the initial angles is 180 degrees;
2) preparing the photocuring slurry:
mixing ceramic powder with a light-cured resin monomer, a photoinitiator, a dispersant, a polymerization inhibitor, a leveling agent and a defoaming agent, and carrying out ball milling in a ball mill for 20min to obtain a uniform suspension state;
the ceramic powder is 35-55 parts by volume, and the average particle size of the ceramic powder is 1-10 mu m; 45-65 parts of a photo-curing resin monomer by volume; the mass of the photo-curing resin monomer is 1-10 percent of that of the photo-curing resin monomer; based on the mass of the ceramic powder, the dispersant accounts for 2-5% of the mass of the ceramic; the mass of the polymerization inhibitor is 15-20% of that of the photoinitiator; the leveling agent and the defoaming agent respectively account for 1-5% of the mass of the photo-curing resin monomer;
3) adjusting and printing photocuring parameters:
adjusting technological parameters of photocuring, wherein the technological parameters comprise exposure intensity, exposure time and layering thickness, and printing the ceramic slurry by using a DLP surface exposure technology to obtain a biscuit;
4) degreasing and sintering the biscuit:
placing the printed biscuit in a tubular sintering furnace, heating to 500-700 ℃ at the speed of 0.5-1 ℃/min, preserving heat for 1-3 h, and removing the photo-curing resin monomer; and then heating to 1050-1450 ℃ at the speed of 3-5 ℃/min, preserving the heat for 2-3 h, naturally cooling in a furnace, and completely sintering the ceramic product.
The light-cured resin monomer is one or more of isodecyl acrylate, ethoxy ethyl acrylate, hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxyethyl methacrylate, hydroxypropyl methacrylate, glycidyl methacrylate, tetrahydrofuran methyl acrylate, phenoxy ethyl acrylate, triethylene glycol diacrylate, polyethylene glycol diacrylate series and dipropylene glycol diacrylate; the photoinitiator is phenyl bis (2,4, 6-trimethyl benzoyl) phosphine oxide, 819 for short; the dispersant is one of digao Dego wetting dispersant 685, KH550, KH560, KH570 or KOS 110; the polymerization inhibitor is MQ, the flatting agent is Dego Glide B1484, and the defoaming agent is Dego Airex 900.
The exposure intensity of the DLP surface exposure technology is 20-30 mW/cm2, the exposure time is 2-8 s, and the layering thickness is 10-60 mu m.
The invention has the beneficial effects that:
1. the spiral pipeline and the vortex pipeline of the spiral pipeline elastic biological ceramic support have certain elasticity in the longitudinal direction and the transverse direction, have larger deformation, and solve the problems that the common biological ceramic support is not easy to deform, has large brittleness and is easy to break.
2. The preparation process of the elastic biological ceramic support for the spiral pipeline, disclosed by the invention, provides a faster and more effective way for preparing the elastic biological ceramic support for the spiral pipeline, and can form a complex structure and has a simple process.
Drawings
FIG. 1 is a schematic diagram of two groups of horizontal assemblies of the elastic bioceramic scaffold for spiral pipes according to the embodiment of the invention.
FIG. 2 is a schematic diagram showing the model dimensions of the elastic bioceramic scaffold for spiral pipes according to the embodiment of the present invention.
FIG. 3 is a flow chart of a process for preparing the elastic bioceramic scaffold for the helical tube according to the embodiment of the invention.
FIG. 4 is a schematic diagram of four groups of horizontal assemblies of the elastic bioceramic stent for spiral pipes according to the embodiment of the invention.
Detailed Description
In order to more fully understand the technical content of the present invention, the technical solutions provided by the present invention will be further described and explained below with reference to the embodiments and the accompanying drawings.
Referring to fig. 1, the spiral pipeline elastic bioceramic scaffold comprises two groups of horizontal assemblies 1 arranged in the vertical direction, and the two groups of horizontal assemblies 1 are connected through a vertical support body 2 for supporting.
The horizontal assembly 1 comprises three circular pipelines 1-a, and the circular pipelines 1-a are connected through three vortex pipelines 1-b; the circular ring pipeline 1-a comprises a first circular ring pipeline 1-a1A second circular pipeline 1-a2A third circular pipeline 1-a3The diameters of central circular lines of the circular ring pipelines of the same horizontal assembly 1 are different, and the sizes of the central circular lines are between 10mm and 30 mm; the scroll pipe 1-b includes a first scroll pipe 1-b1Second scroll pipe 1-b2Third scroll pipe 1-b3Each vortex pipeline can be connected with all the circular ring pipelines in the same horizontal assembly 1, the central vortex line pitches of the vortex pipelines in the same horizontal assembly 1 are the same, and the sizes of the vortex pipelines are 15 mm-55 mm. The vortex pipeline enables the support to have certain elasticity in the transverse direction and has larger deformation.
The vertical support body 2 is composed of two layers of spiral pipelines 2-a from outside to inside, the number of the layers is the number of the circular pipelines in the horizontal assembly 1 minus 1, and the diameter of the central spiral line of each spiral pipeline is correspondingly equal to the diameter of the central line of the other circular pipelines except the smallest circular pipeline in the horizontal assembly 1; the spiral duct 2-a comprises a first spiral duct 2-a1Second spiral pipe 2-a2(ii) a The central spiral lines of the spiral pipelines in different layers have different diameters, and the size of the central spiral lines is between 10mm and 30 mm; the screw pitches of the screw pipelines at different layers are the same, and are 4mm to up to four20mm between; the spiral pipeline of the same layer is composed of two spiral pipelines with different initial angles and the same other parameters, and the difference of the initial angles is 180 degrees. The spiral pipeline enables the support to have certain elasticity in the longitudinal direction and larger deformation.
The circular pipeline, the vortex pipeline and the spiral pipeline are hollow pipelines, the diameter of an outer circle of each hollow pipeline is between 2mm and 6mm, and the diameter of an inner circle of each hollow pipeline is between 0.5mm and 4 mm.
The circular pipeline, the vortex pipeline and the spiral pipeline are provided with holes with diameters of 0.3 mm-3 mm on the surfaces, degradable polymers are poured into the hollow pipeline through the holes to increase the elasticity of the hollow pipeline, and the degradable polymers are polycaprolactone, polylactic acid or polylactic acid-polyglycolic acid.
Referring to fig. 2, the spiral pipeline is used as a spring model, the whole spiral pipeline elastic biological ceramic support is simplified into a series-parallel connection model of the spring, the stiffness coefficient of one spring model is derived from an energy equation, the work done by the spring by external force is all equal to the increment of the elastic potential energy of the spring, the acting force acting on the spring is F, the deformation of the spring is lambda, and then the spring has
Wherein G is the shear modulus of the ceramic material; n-the effective number of turns of the ceramic spring; d, the pitch diameter of the ceramic spring; d2-the outer diameter of the tube of the ceramic spring; d1Inner diameter of the tube of the ceramic spring.
Referring to fig. 3, a preparation process of a spiral pipe elastic bioceramic scaffold comprises the following steps:
1) model establishment and processing:
according to the actual use condition of the spring, modeling the elastic ceramic with the spiral structure by using solidworks, and designing the diameters of the outer circle and the inner circle of all pipelines of the elastic biological ceramic support of the spiral pipeline and the diameters of small holes on the pipelines, the number of groups of circular pipeline, the diameter of central circular line of the circular pipeline, the number of groups of vortex pipeline, the central vortex line pitch of the vortex pipeline, the number of groups of the spiral pipeline, the central spiral line diameter of the spiral pipeline and the pitch; wherein the diameters of the outer circles of the circular pipeline, the vortex pipeline and the spiral pipeline are 2mm, the diameter of the inner circle is 1mm, and the diameter of the small hole is 0.5 mm; the number of the circular pipelines in the same horizontal assembly 1 is three, and the diameters of central circular lines of the circular pipelines in the same horizontal assembly 1 are different, and the diameters are 5mm, 15mm and 25 mm; the number of the vortex pipelines in the same horizontal assembly 1 is three, the central vortex line pitches of the inner vortex pipelines are the same, and the sizes of the inner vortex pipelines are 25 mm; the number of the spiral pipeline layers is two, and the diameter of a central spiral line of the spiral pipeline at the outermost layer is equal to the diameter of the central line of the largest circular pipeline in a horizontal combined body correspondingly and is 25 mm; the diameter of the central spiral line of the secondary outer layer spiral pipeline is equal to the diameter of the central line of the middle ring pipeline in a horizontal combination body correspondingly and is 15mm, the spiral line pitches of different layers of spiral pipelines are the same, the pitch is 12, the same layer of spiral pipeline is composed of two spiral pipelines with different initial angles and the same other parameters, and the initial angles are different by 180 degrees;
2) preparing the photocuring slurry:
mixing ceramic powder with a light-cured resin monomer, a photoinitiator, a dispersant, a polymerization inhibitor, a leveling agent and a defoaming agent, and carrying out ball milling in a ball mill for 20min to obtain a uniform suspension state;
the ceramic powder is calcium silicate powder, and the ceramic powder accounts for 40 parts by volume and 16 g; the average particle size of the ceramic powder was 3.56 μm; the photocuring resin monomer is isodecyl acrylate, and the volume portion is 60 parts and 11 g; the photoinitiator is 2% of the photocurable resin monomer by mass, and the photoinitiator is phenyl bis (2,4, 6-trimethylbenzoyl) phosphine oxide; based on the mass of the ceramic powder, the dispersant is digao Dego wetting dispersant 685, which is 3% of the mass of the ceramic; the mass of the polymerization inhibitor is 20 percent of that of the photoinitiator, and the polymerization inhibitor is MQ; the mass of the photo-curing resin monomer is counted, the leveling agent is Dego GlideB 1484, the defoaming agent is Dego Airex 900, and the leveling agent and the defoaming agent respectively account for 1% of the photo-curing resin monomer.
3) Adjusting and printing photocuring parameters:
adjusting technological parameters of photocuring, wherein the technological parameters comprise exposure intensity, exposure time and layering thickness, performing a single-layer experiment on the ceramic slurry, determining that the exposure intensity is 30mW/cm2, the exposure time is 3s, and the layering thickness is 35um, and printing the ceramic slurry by using a DLP surface exposure technology to obtain a biscuit;
4) degreasing and sintering the biscuit:
placing the printed biscuit in a tubular sintering furnace, heating to 600 ℃ at the speed of 0.5 ℃/min, preserving heat for 1h, and removing the photocuring resin monomer; then raising the temperature to 1250 ℃ at the speed of 5 ℃/min, preserving the temperature for 2 hours, and then naturally cooling in a furnace to completely sinter the ceramic parts.
Obviously, the above-described embodiments are only 1 embodiment of the present invention, and not all embodiments, for example, a spiral tube elastic bioceramic scaffold formed by connecting four sets of horizontal assemblies and three sets of vertical supports is shown in fig. 4. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (8)
1. The utility model provides a biological ceramic support of spiral pipeline elasticity which characterized in that: the device comprises more than two groups of horizontal combination bodies (1) arranged in the vertical direction, wherein the two adjacent groups of horizontal combination bodies (1) are connected through a vertical support body (2) for supporting;
the horizontal assembly (1) comprises more than two circular pipelines (1-a), and the circular pipelines (1-a) are connected through more than two vortex pipelines (1-b); the diameters of central circular lines of the circular ring pipelines of the same horizontal assembly (1) are different, and the sizes of the central circular lines are between 10mm and 30 mm; each vortex pipeline can be connected with all circular ring pipelines in the same horizontal assembly (1), the central vortex line pitches of the vortex pipelines in the same horizontal assembly (1) are the same, and the sizes of the vortex pipelines are 15-55 mm;
the vertical supporting body (2) is composed of more than one layer of spiral pipelines (2-a) from outside to inside, the number of the layers is reduced by 1 from the number of circular pipelines in one horizontal assembly (1), and the diameter of a central spiral line of each spiral pipeline is correspondingly equal to the diameter of the central line of the other circular pipelines except the smallest circular pipeline in one horizontal assembly (1); the central spiral lines of the spiral pipelines in different layers have different diameters, and the size of the central spiral lines is between 10mm and 30 mm; the screw pitches of the spiral pipelines in different layers are the same, and the screw pitches are between 4mm and 20 mm; the spiral pipeline of the same layer is composed of two spiral pipelines with different initial angles and the same other parameters, and the difference of the initial angles is 180 degrees.
2. The elastic bioceramic scaffold for spiral pipes according to claim 1, wherein: the circular pipeline, the vortex pipeline and the spiral pipeline are hollow pipelines, the diameter of an outer circle of each hollow pipeline is between 2mm and 6mm, and the diameter of an inner circle of each hollow pipeline is between 0.5mm and 4 mm.
3. The elastic bioceramic scaffold for spiral pipes according to claim 1, wherein: the circular pipeline, the vortex pipeline and the spiral pipeline are provided with holes with the diameter of 0.3 mm-3 mm on the surfaces, and degradable polymers are poured into the hollow pipeline through the holes, wherein the degradable polymers are polycaprolactone, polylactic acid or polylactic acid-polyglycolic acid.
4. The elastic bioceramic scaffold for spiral pipes according to claim 1, wherein: the spiral pipeline is used as a spring model, the whole spiral pipeline elastic biological ceramic support is simplified into a series-parallel connection model of the spring, the stiffness coefficient of one spring model is derived from an energy equation, the work done by the spring by external force is all equal to the increment of the elastic potential energy of the spring, the acting force acting on the spring is F, the deformation of the spring is lambda, and then the spring has the advantages that Wherein G is the shear modulus of the ceramic material; n-the effective number of turns of the ceramic spring; d, the pitch diameter of the ceramic spring; d2Outside the pipe of the ceramic springDiameter; d1Inner diameter of the tube of the ceramic spring.
5. The elastic bioceramic scaffold for spiral pipes according to claim 1, wherein: the ceramic of the spiral pipeline elastic biological ceramic support is made of one or a combination of more of tricalcium phosphate, calcium silicate, hydroxyapatite, zirconia, magnesia, alumina, silica and titanium dioxide according to the requirements of required rigidity, strength and elastic performance.
6. The preparation process of the elastic biological ceramic bracket for the spiral pipe according to claim 1, which is characterized by comprising the following steps:
1) model establishment and processing:
according to the implantation requirement of the biological ceramic support, the diameters of the outer circle and the inner circle of all pipelines of the elastic biological ceramic support of the spiral pipeline and the diameters of small holes on the pipelines are designed, the number of circular pipeline groups, the diameter of a central circular line of the circular pipeline, the number of vortex pipeline groups, the pitch of a central vortex line of the vortex pipeline, the number of spiral pipeline groups, the diameter of a central spiral line of the spiral pipeline and the pitch of the spiral line are designed; wherein the diameters of the outer circles of the circular pipeline, the vortex pipeline and the spiral pipeline are between 2mm and 6mm, the diameter of the inner circle is between 0.5mm and 4mm, and the diameter of the small hole is between 0.3mm and 3 mm; the number of the circular pipelines in the same horizontal assembly (1) is more than two, and the central circular lines of the internal circular pipelines have different diameters and the size is between 10mm and 30 mm; the number of the vortex pipelines in the same horizontal assembly (1) is two and above, the central vortex line pitches of the inner vortex pipelines are the same, and the sizes of the inner vortex pipelines are between 15mm and 55 mm; the number of the spiral pipeline layers is reduced by 1 from the number of the circular pipeline in one horizontal assembly (1), the diameter of the central spiral line of the spiral pipeline is correspondingly equal to the diameter of the central line of the other circular pipeline except the smallest circular pipeline in one horizontal assembly (1), the diameters of the central spiral lines of the spiral pipelines in different layers are different, and the size of the spiral pipeline is 10-30 mm; the screw pitches of the spiral pipelines in different layers are the same, and the screw pitches are between 4mm and 20 mm; the same layer of spiral pipeline is composed of two spiral pipelines with different initial angles and the same other parameters, and the difference of the initial angles is 180 degrees;
2) preparing the photocuring slurry:
mixing ceramic powder with a light-cured resin monomer, a photoinitiator, a dispersant, a polymerization inhibitor, a leveling agent and a defoaming agent, and carrying out ball milling in a ball mill for 20min to obtain a uniform suspension state;
the ceramic powder is 35-55 parts by volume, and the average particle size of the ceramic powder is 1-10 mu m; 45-65 parts of a photo-curing resin monomer by volume; the mass of the photo-curing resin monomer is 1-10 percent of that of the photo-curing resin monomer; based on the mass of the ceramic powder, the dispersant accounts for 2-5% of the mass of the ceramic; the mass of the polymerization inhibitor is 15-20% of that of the photoinitiator; the leveling agent and the defoaming agent respectively account for 1-5% of the mass of the photo-curing resin monomer;
3) adjusting and printing photocuring parameters:
adjusting technological parameters of photocuring, wherein the technological parameters comprise exposure intensity, exposure time and layering thickness, and printing the ceramic slurry by using a DLP surface exposure technology to obtain a biscuit;
4) degreasing and sintering the biscuit:
placing the printed biscuit in a tubular sintering furnace, heating to 500-700 ℃ at the speed of 0.5-1 ℃/min, preserving heat for 1-3 h, and removing the photo-curing resin monomer; and then heating to 1050-1450 ℃ at the speed of 3-5 ℃/min, preserving the heat for 2-3 h, naturally cooling in a furnace, and completely sintering the ceramic product.
7. The preparation process of the elastic biological ceramic bracket for the spiral pipe according to claim 6, wherein the preparation process comprises the following steps: the light-cured resin monomer is one or more of isodecyl acrylate, ethoxy ethyl acrylate, hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxyethyl methacrylate, hydroxypropyl methacrylate, glycidyl methacrylate, tetrahydrofuran methyl acrylate, phenoxy ethyl acrylate, triethylene glycol diacrylate, polyethylene glycol diacrylate series and dipropylene glycol diacrylate; the photoinitiator is phenyl bis (2,4, 6-trimethyl benzoyl) phosphine oxide, 819 for short; the dispersant is one of digao Dego wetting dispersant 685, KH550, KH560, KH570 or KOS 110; the polymerization inhibitor is MQ, the flatting agent is Dego Glide B1484, and the defoaming agent is Dego Airex 900.
8. The preparation process of the elastic biological ceramic bracket for the spiral pipe according to claim 6, wherein the preparation process comprises the following steps: the exposure intensity of the DLP surface exposure technology is 20-30 mW/cm2, the exposure time is 2-8 s, and the layering thickness is 10-60 mu m.
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| CN115194179A (en) * | 2021-04-12 | 2022-10-18 | 中国航发商用航空发动机有限责任公司 | Support structure and method for manufacturing spiral pipeline |
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