CN110793897A - Penetration test system and method - Google Patents
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- CN110793897A CN110793897A CN201810862383.1A CN201810862383A CN110793897A CN 110793897 A CN110793897 A CN 110793897A CN 201810862383 A CN201810862383 A CN 201810862383A CN 110793897 A CN110793897 A CN 110793897A
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
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Abstract
The invention provides a penetration test system and a test method, belonging to the technical field of medical detection, wherein the penetration test system comprises a penetration test device, an analysis instrument, a conveying pipeline and a pumping device; the penetration test device is provided with a challenge chamber which is separated by a test material and is used for containing chemicals and a collection chamber which is used for containing a collection medium; the chemicals are higher than the concentration of the collection medium, the collection chamber is communicated with a first circulation channel and a second circulation channel, an outlet of the first circulation channel is communicated with an input port of an analysis instrument through a conveying pipeline, an output port of the analysis instrument is communicated with the second circulation channel through a conveying pipeline, and the pumping device is arranged on the conveying pipeline. The test system can be used for detecting the permeation amount of the chemicals in the collecting medium, so that the chemical permeation resistance of the test material (gloves) is obtained.
Description
Technical Field
The invention relates to the technical field of medical detection, in particular to a penetration testing system and a testing method.
Background
During work, medical staff may contact certain chemicals which are harmful to healthy people, such as various disinfectants (such as hydrogen peroxide), chemicals (such as various chemotherapeutic drugs) and the like. When directly exposed to various harmful chemicals, various levels of injuries are caused to the human body, acute wounds such as skin irritation and burn, and chronic degenerative diseases such as cancer. Therefore, the medical staff usually pay special attention to wearing protective articles such as medical gloves during daily work to avoid potential harm caused by direct skin contact. Therefore, the medical gloves need to have certain safety performance of resisting permeation and degradation of various chemicals and the like so as to achieve the purpose of effective protection.
The medical gloves mainly comprise disposable sterilized rubber surgical gloves, disposable medical rubber examination gloves and the like, and are generally divided into two types of natural latex gloves and nitrile rubber gloves according to different raw material materials. However, the standards of various medical gloves do not have the performance index requirement of resisting the penetration of chemicals. At present, no test method for evaluating the chemical permeation resistance of the medical gloves is seen in China. Therefore, at present, all kinds of medical gloves do not mark related chemical permeation resistance levels or related performance requirements, medical workers cannot judge the protective performance of the gloves when using the gloves, and the gloves can not be worn freely and can not be effectively protected by themselves. If the multilayer wearing is adopted, the operation is inconvenient, and even the operation error is caused seriously.
In view of the above, it is necessary to provide a penetration testing system and a penetration testing method for evaluating the chemical resistance of medical gloves, so as to determine the penetration performance of the chemical on the protective glove material under the contact condition within a certain duration.
Disclosure of Invention
A first object of the present invention is to provide a penetration test system that solves the above-mentioned drawbacks of the prior art and is able to determine the penetration of a chemical into a protective glove material under contact conditions over a certain duration of time.
The second purpose of the invention is to provide a testing method adopting the penetration testing system.
Based on the first object, the present invention provides a penetration test system, comprising: the device comprises a penetration test device, an analytical instrument, a conveying pipeline and a pumping device;
the penetration test device is provided with a challenge chamber which is formed by separating test materials and is used for containing a chemical to be tested and a collection chamber which is used for containing a collection medium; the chemical is higher than the concentration of the collecting medium, the collecting chamber is communicated with a first circulating channel and a second circulating channel, an outlet of the first circulating channel is communicated with an input port of the analytical instrument through a conveying pipeline to convey the collecting medium to the analytical instrument, an output port of the analytical instrument is communicated with the second circulating channel of the permeation experimental device through a conveying pipeline to discharge the collecting medium to the collecting chamber, and the pumping device is arranged on the conveying pipeline to provide the collecting medium flow force.
According to the technical scheme, the chemical to be tested is injected into the challenge chamber, the collecting medium is injected into the collecting chamber, one side of the test material is in contact with the chemical, the other side of the test material is in contact with the collecting medium, and the chemical and the collecting medium have concentration difference, so that in the process that the chemical gradually permeates from the test material to the collecting medium, the permeation amount of the chemical in the collecting medium is detected through circulation of the collecting medium among the collecting chamber, the first circulation channel, the second circulation channel, the conveying channel and the analysis instrument, the breakthrough detection time, the standard breakthrough time, the permeation rate, the accumulated permeation amount and other numerical values of the test chemical are obtained, and the chemical permeation resistance of the test material (gloves) can be visually judged.
Further, the penetration test device comprises a first shell, a second shell and a clamping element for assembling test materials, wherein the first shell and the second shell are connected,
the clamping element is arranged between the first shell and the second shell;
the challenge chamber is arranged in the first shell, and the collection chamber and the first circulation channel and the second circulation channel which are respectively communicated with the collection chamber are arranged in the second shell.
Among the above-mentioned technical scheme, utilize the clamping component to fix the test material to be convenient for assemble through first casing and second casing through the clamping component, thereby guarantee penetration test device's sound construction reliable, detect simple easy operation.
Further, the first shell, the second shell and the clamping element are detachably connected. Thereby facilitating cleaning or replacement of the first housing, the second housing, and the material to be tested.
Further, the clamping element comprises two gaskets, the test material is clamped between the two gaskets, and the two gaskets are respectively provided with openings so that two sides of the test material can be respectively contacted with the collecting medium and the chemicals.
Among the above-mentioned technical scheme, adopt the mode of two gasket clamping test materials, have simple structure, reliable and stable characteristics.
Further, the collection chamber also has a collection medium inlet therein to facilitate injection of the collection medium into the collection chamber.
Furthermore, the challenge chamber is also provided with a chemical input port, so that the chemical to be tested can be injected into the challenge chamber conveniently.
Furthermore, the device also comprises a temperature control device, wherein the temperature control device is used for enabling the penetration test device to be in a set working temperature range.
Furthermore, the temperature control device adopts a heat preservation box body or a constant temperature water bath.
Furthermore, the pumping device adopts a peristaltic pump to adjust the flow of the collected medium in the conveying pipeline, and the peristaltic pump has the characteristic of high stability and precision in flow adjustment.
Based on the second objective, the invention provides a testing method based on the penetration testing system, which comprises the following steps:
step S1, the penetration test device is in the constant temperature range of 37 +/-1.0 ℃, the device is preheated for at least 30min,
step S2, preheating the collection medium to 37 +/-1.0 ℃, adding the collection medium into the collection chamber, and starting a circulating pump to enable the collection medium to form circulating flow through the collection chamber, a conveying pipeline and an analysis instrument so as to ensure the uniformity of an analysis sample;
step S3, rapidly adding the test chemical into the challenge chamber until the test material is completely covered by the chemical, and starting the test timing from the addition of the chemical;
and step S4, selecting proper analysis and detection technology for determination according to the property of the collection medium, thereby calculating at least the values of breakthrough detection time, standard breakthrough time, permeation rate and accumulated permeation quantity of the test chemical.
By adopting the technical scheme, the penetration testing system provided by the invention has the technical effects that:
in the penetration test system provided by the invention, a challenge chamber is used for injecting a chemical to be tested, a collection chamber is used for injecting a collection medium, one side of a test material is contacted with the chemical, the other side of the test material is contacted with the collection medium, due to the concentration difference between the chemical and the collection medium, during the gradual penetration of the chemical from the test material to the collection medium, by circulating the collection medium between the collection chamber, the first and second circulation channels, the transport channel and the analysis instrument, detecting the penetration amount of the chemicals in the collecting medium to obtain the values of breakthrough detection time, standard breakthrough time, penetration rate, accumulated penetration amount and the like of the tested chemicals, the chemical permeation resistance of the test material (gloves) can be visually judged, the current situation that the chemical permeation resistance of medical gloves cannot be evaluated at home at present is solved, and technical guarantee is provided for protecting the personal safety of medical personnel.
The testing method based on the penetration testing system provided by the invention can realize the purpose of continuous detection, improves the efficiency of testing personnel, greatly reduces the detection cost, and has large test data acquisition amount, more accuracy and precision. The defects caused by off-line detection, such as uncertainty of the protective performance of the material, frequent sampling and trouble of multiple times of measurement, are avoided.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a schematic structural diagram of an infiltration testing system provided in an embodiment of the present invention;
fig. 2 is a schematic view of a first perspective structure of an permeation test apparatus in a permeation test system according to an embodiment of the present invention;
fig. 3 is a schematic view of a second perspective structure of an infiltration testing apparatus in the infiltration testing system according to the embodiment of the present invention.
Reference numerals: 100-penetration test device; 110-a first housing; 111-challenge chamber; 112-a chemical input port; 120-a second housing; 121-a collection chamber; 122 — first circulation path; 123-a second circulation channel; 124-a collection media input port; 130-a clamping element; 131-a spacer; 140-a flange; 200-an analytical instrument; 300-a delivery conduit; 400-a pumping device; 500-test material; 600-temperature control device.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
The embodiment of the invention mainly aims to establish a test system for evaluating the chemical permeation resistance of medical gloves and a test method based on the test system, and the permeation of chemicals to protective glove materials under a contact condition within a certain duration is measured.
The construction of the penetration test system is based on the penetration principle. When the medical gloves are made of high polymer product materials, when the medical gloves are contacted with liquid chemicals, permeation of the medical gloves is based on concentration difference of the chemicals, the medical gloves move through the medical gloves in a molecular form, namely permeation, and the permeation process comprises adsorption-diffusion-desorption, and the specific steps are as follows:
a) absorption of chemicals into the material contact surface;
b) the absorbed molecules diffuse throughout the material;
c) the chemicals desorb from opposite sides of the material.
The main technical contents of the construction of the penetration testing system comprise: the construction of the test device (permeation test device, configuration of closed circulation route, configuration of suitable test instrument), the establishment of various parameters of the test (circulation rate, determination of test time and period) and the specific test steps.
Through test results and analysis, breakthrough detection time, standard breakthrough time, permeation rate and accumulated permeation value of the medical glove material are obtained, and the indexes are key indexes for evaluating the chemical isolation effectiveness of the medical glove material as a protective barrier.
The breakthrough detection time refers to the elapsed time from the time when the chemicals on the two sides of the test material and the collecting medium are injected in place to the time when the content of the chemicals in the collecting medium is detected by the analyzer for the first time; the breakthrough detection time depends on the sensitivity of the test method.
The standard breakthrough time mentioned above refers to the time until the permeation rate reached 0.1. mu.g/cm 2/min.
The longer the breakthrough detection time and the standard breakthrough detection time are, the smaller the accumulated permeation quantity and the permeation rate are, which indicates that the better the isolation characteristic of the medical glove material is, the stronger the protection effect on human body is. In the process of selecting the dangerous chemical protective articles, medical staff can visually compare the advantages and disadvantages of the protective performance of the medical gloves through the index values marked in the glove specifications, and select proper products to achieve effective safety protection.
The penetration test system provided in the examples of the present invention will be described in detail below.
As shown in fig. 1, 2 and 3, the penetration test system includes: the permeation testing apparatus 100, the analytical instrument 200, the delivery conduit 300, and the pumping device 400.
The penetration test device 100 is provided with a challenge chamber 111 which is formed by separating a test material 500 and is used for containing a chemical to be tested, and a collection chamber 121 which is used for containing a collection medium; the chemical is higher than the concentration of the collecting medium, the collecting chamber 121 is communicated with a first circulation channel 122 and a second circulation channel 123, the outlet of the first circulation channel 122 is communicated with the input port of the analytical instrument 200 through a conveying pipeline 300 for conveying the collecting medium to the analytical instrument 200, the output port of the analytical instrument 200 is communicated with the second circulation channel 123 of the permeation experimental device through the conveying pipeline 300 for discharging the collecting medium into the collecting chamber 121, and a pumping device 400 is arranged on the conveying pipeline 300 for providing the flow force of the collecting medium.
The transfer pipe 300 is preferably made of silicon rubber, and the permeation testing apparatus 100, the analyzer 200, and the pumping unit 400 are connected in series to form a closed circulation line by the transfer pipe 300.
In the above technical solution, a chemical to be tested is injected into the challenge chamber 111, a collection medium is injected into the collection chamber 121, one side of the test material 500 contacts the chemical, and the other side of the test material 500 contacts the collection medium, because the chemical and the collection medium have a concentration difference, the chemical gradually permeates from the test material 500 to the collection medium, and the permeation amount of the chemical in the collection medium is detected through the circulation of the collection medium among the collection chamber 121, the first circulation channel 122, the second circulation channel 123, the delivery channel and the analysis instrument 200, so that the values of breakthrough detection time, standard breakthrough time, permeation rate, cumulative permeation amount and the like of the test chemical are obtained, and the chemical permeation resistance of the test material 500 (gloves) can be visually judged.
In a preferred embodiment of this embodiment, as shown in fig. 2 and 3, the permeation test apparatus 100 comprises a first housing 110, a second housing 120 and a clamping member 130 for assembling a test material 500;
the clamping member 130 is disposed between the first housing 110 and the second housing 120;
the challenge chamber 111 is provided in the first housing 110, and the collection chamber 121 and the first and second circulation passages 122 and 123 respectively communicating with the collection chamber 121 are provided in the second housing 120.
In specific implementation, the first housing 110 and the second housing 120 are preferably made of glass (or stainless steel), and because the chemical to be tested has a difference in acid and alkali, when the chemical (such as hydrofluoric acid) used in the test corrodes the glass, the stainless steel material is used instead. Because the size difference between the palm part and the finger part of the medical glove is large, test cells of a) and b) with different sizes are designed and processed according to the structure of a glove product.
a) The diameter d is 2.54 cm. The length of the challenge chamber 111 is about 2.5cm, and the length of the collection chamber 121 is less than or equal to 3.2 cm.
b) The diameter d is 5.00 cm. The length of the challenge chamber 111 is about 2.0cm, and the length of the collection chamber 121 is less than or equal to 4.0 cm.
It should be noted that the diameter d refers to the diameter of the ports of the collection chamber 121 and the challenge chamber 111.
For ease of installation, the ports of the collection 121 and challenge 111 chambers are preferably designed to be turned outwardly into a flange 140 to facilitate gripping of the collection 121 and challenge 111 chambers during testing, and further, the internal diameters of the pipes, ports, etc. are preferably not too thin (at least 2mm) to prevent additional pressure differentials in the system.
In the above technical solution, the clamping element 130 is used to fix the test material 500, and the first housing 110 and the second housing 120 are convenient to assemble through the clamping element 130, so that the penetration test apparatus 100 is ensured to have a firm and reliable structure and simple and easy detection and operation.
In a preferred embodiment of this embodiment, the first housing 110, the second housing 120 and the clamping member 130 are detachably connected, so as to facilitate cleaning or replacement of the first housing 110, the second housing 120 and the test material 500.
In specific implementation, the first housing 110 and the second housing 120 are provided with flanges 140, the clamping member 130 is provided with through holes, and bolts simultaneously penetrate through the flanges 140 and the through holes to fix the first housing 110, the second housing 120 and the clamping member 130 together.
In a preferred embodiment of this embodiment, the clamping element 130 comprises two gaskets 131, the test material 500 is clamped between the two gaskets 131, and the two gaskets 131 are respectively provided with openings for allowing two sides of the test material 500 to respectively contact the collecting medium and the chemical. During specific implementation, the positions of the two openings correspond to each other, so that chemicals can be enabled to be fully seeped into a collecting medium by the test material 500, and guarantee is provided for accuracy of detection data.
In the technical scheme, the mode of clamping the test material 500 by the two gaskets 131 is adopted, and the device has the characteristics of simple structure, stability and reliability.
In a preferred embodiment of this embodiment, the collection chamber 121 is further provided with a collection medium inlet 124 therein to facilitate injection of the collection medium into the collection chamber 121.
Similarly, the challenge chamber 111 also has a chemical input port 112 therein to facilitate the injection of the chemical to be tested into the challenge chamber 111.
In a preferred embodiment of this embodiment, the permeation testing system further comprises a temperature control device 600, wherein the temperature control device 600 is configured to enable the permeation testing device 100 to be within a set operating temperature range.
In specific implementation, the temperature control device 600 preferably adopts a heat preservation box or a thermostatic water bath. The test temperature for maintaining the penetration test device 100 is in the range of 37 +/-1.0 ℃, and the temperature is determined based on the actual use temperature reached when the glove is worn on a human body, so that the accuracy and reliability of the detection data are guaranteed.
In a preferred embodiment of this embodiment, the pumping device 400 employs a peristaltic pump to adjust the flow rate of the collected medium in the conveying pipeline 300, and the peristaltic pump has a characteristic of high accuracy in adjusting the flow rate.
The peristaltic pump is installed on the transport pipe 300 upstream or downstream of the permeation test apparatus 100, and is used to transport the collection medium to and from the permeation test apparatus 100, the on-line detection analysis instrument 200, and form a closed loop. The flow rate of the peristaltic pump may be adjusted, with different flow rates being selected for the test based on the size of the permeation test apparatus 100.
The on-line detection analyzer 200 provided in this embodiment selects an on-line detection analysis technique, and can set appropriate parameters of the analyzer, such as a measurement interval time and a test period, and automatically records a test result through software provided in the analyzer 200. Depending on the nature of the test chemical, analytical detection techniques for the test may be selected, typically including but not limited to: ultraviolet and infrared spectrophotometry, gas/liquid chromatography, optical/electrochemical methods, and the like.
The test method based on the penetration test system provided by the embodiment of the invention comprises the following steps:
step S1, putting the assembled penetration test device 100 into a 37 ℃ constant temperature box or constant temperature water bath, enabling the penetration test device 100 to be in a constant temperature range of 37 +/-1.0 ℃, preheating for at least 30min, and during the test period, the test pool can not be taken out of the water bath box;
step S2, preheating the collection medium to 37 ℃ +/-1.0 ℃, adding the collection medium into the collection chamber 121, starting a circulating pump to enable the collection medium to form a circulating flow through the collection chamber 121, the conveying pipeline 300 and the analysis instrument 200, and preventing or minimizing a concentration boundary layer of permeate at the contact surface of the medical glove material and the collection medium so as to ensure the uniformity of an analysis sample; typically the minimum circulation flow of the collection medium is 5 times the volume of the collection chamber 121 per minute;
step S3, rapidly adding the test chemical into the challenge chamber 111 until the test material 500 is completely covered by the chemical, and starting the test timing from the addition of the chemical; during the process of adding the test chemicals, the direct impact on the sample material (the sample material can be injected by a suitable device such as a cannula or a syringe) is avoided, and the generation of bubbles is avoided;
step S4, selecting appropriate analysis and detection techniques for determination based on the collection medium properties, and for continuous on-line analysis, the analyzer 200 will carry its own analysis mapping software. And setting appropriate test interval time and test time so as to calculate at least values of breakthrough detection time, standard breakthrough time, permeation rate and accumulated permeation quantity of the test chemical.
During the test, sampling was stopped and the test was terminated when one or more of the following conditions were met:
a) steady state permeation is achieved. Typically, steady state permeation is achieved when the test chemical concentration in the collection chamber 121 increases at a constant rate.
b) Infiltration proceeds at a continuously increasing rate.
c) The maximum rate has been reached and the steady state permeation rate has not been reached within 30min of reaching the maximum rate.
d) The predetermined time has elapsed. The typical duration of the test was 4 h.
In addition, the mixing agents and curing agents frequently used in medical glove materials can interfere with the detection data. Therefore, before the test chemical is added to the challenge chamber 111, the test is started on the respective parameter values of the mixing agent and the curing agent as baseline values for comparison of subsequent analytical data.
According to the test system and the test method for evaluating the chemical permeation resistance of the medical gloves, the chemical permeation resistance of the gloves can be quantitatively and visually objectively judged according to the relevant numerical values obtained by the test system and the test method.
For example, a butyronitrile medical glove on the market nominally has a protective effect on common chemotherapy drugs, and the test system and the test method are adopted to test 4 chemotherapy drugs in the treatment of cancer, which are commonly used in clinic at present, and the results are as follows: the average penetration time of the carmustine injection is about 23 minutes, and the average penetration rate is 0.8 mu g/cm2/min when the steady state is reached; the average penetration time of the thiotepa injection is about 39 minutes, and the average penetration rate is 1.4 mu g/cm2/min when the injection reaches a steady state; while the other two drugs, taxol and doxorubicin hydrochloride, were both penetrating within 4 h.
The longer the breakthrough detection time and the standard breakthrough detection time are, the smaller the accumulated permeation quantity and the permeation rate are, which indicates that the better the isolation characteristic of the medical glove material is, the stronger the protection effect on human body is. The average penetration time of the gloves is directly marked on the outer package, and medical workers can select medical gloves with better safety to protect the gloves according to the types of drugs or pay attention to the operation time to operate the gloves within the safe use time when preparing or infusing chemotherapy drugs.
The penetration testing system and the testing method in the embodiment of the invention solve the problem that the chemical penetration resistance of the medical gloves cannot be evaluated at present, and provide technical support for protecting the personal safety of medical personnel.
In addition, the use of the automatic sample introduction online detection analysis instrument 200 in the test system can set appropriate instrument parameters, and automatically record the test result through software carried by the instrument. The defects caused by offline detection, such as uncertainty of material protective performance, frequent sampling and trouble of multiple times of measurement (such as poor protective performance, namely easily permeable materials, the permeation quantity is greatly changed within a few seconds generally, the manual offline detection of a single detector is not in time at all, or a plurality of instruments are required to be operated simultaneously by a plurality of persons to obtain statistically significant data) are avoided. The efficiency of the detection personnel is improved, and the detection cost is greatly reduced. The test data acquisition quantity is large, and the test data acquisition is more accurate and precise.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (10)
1. A penetration test system is characterized by comprising a penetration test device, an analysis instrument, a conveying pipeline and a pumping device;
the penetration test device is provided with a challenge chamber which is formed by separating test materials and is used for containing a chemical to be tested and a collection chamber which is used for containing a collection medium; the chemical is higher than the concentration of the collecting medium, the collecting chamber is communicated with a first circulating channel and a second circulating channel, an outlet of the first circulating channel is communicated with an input port of the analytical instrument through a conveying pipeline to convey the collecting medium to the analytical instrument, an output port of the analytical instrument is communicated with the second circulating channel of the permeation experimental device through a conveying pipeline to discharge the collecting medium to the collecting chamber, and the pumping device is arranged on the conveying pipeline to provide the collecting medium flow force.
2. The permeation testing system according to claim 1, wherein the permeation testing apparatus comprises a first housing, a second housing and a clamping member for assembling a test material,
the clamping element is arranged between the first shell and the second shell;
the challenge chamber is arranged in the first shell, and the collection chamber and the first circulation channel and the second circulation channel which are respectively communicated with the collection chamber are arranged in the second shell.
3. The permeability testing system of claim 2, wherein the first housing, the second housing, and the clamping element are removably coupled.
4. The penetrant testing system of claim 2, wherein the clamping member comprises two gaskets, the test material is clamped between the two gaskets, and the two gaskets are respectively provided with openings to enable both sides of the test material to respectively contact the collection medium and the chemical.
5. The permeation testing system according to claim 1 or 2, wherein the collection chamber further has a collection medium input port therein.
6. The penetrant testing system of claim 1 or 2, wherein the challenge chamber further has a chemical inlet.
7. The penetrant testing system of any one of claims 1-4, further comprising a temperature-control device, wherein the temperature-control device is configured to bring the penetrant testing device within a set operating temperature range.
8. The permeation test system according to claim 7, wherein the temperature control device is an incubator or a thermostatic water bath.
9. The permeability testing system of claim 1, wherein the pumping device employs a peristaltic pump to regulate the flow of the collection medium within the delivery conduit.
10. A method of testing based on the permeability testing system of any one of claims 1-9, comprising the steps of:
step S1, the penetration test device is in the constant temperature range of 37 +/-1.0 ℃, and the penetration test device is preheated for at least 30 min;
step S2, preheating the collection medium to 37 +/-1.0 ℃, adding the collection medium into the collection chamber, and starting a circulating pump to enable the collection medium to form circulating flow through the collection chamber, a conveying pipeline and an analysis instrument so as to ensure the uniformity of an analysis sample;
step S3, rapidly adding the test chemical into the challenge chamber until the test material is completely covered by the chemical, and starting the test timing from the addition of the chemical;
and step S4, selecting proper analysis and detection technology for determination according to the property of the collection medium, thereby calculating at least the values of breakthrough detection time, standard breakthrough time, permeation rate and accumulated permeation quantity of the test chemical.
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| CN201810862383.1A CN110793897A (en) | 2018-08-01 | 2018-08-01 | Penetration test system and method |
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| CN201810862383.1A CN110793897A (en) | 2018-08-01 | 2018-08-01 | Penetration test system and method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111642833A (en) * | 2020-04-22 | 2020-09-11 | 王峰 | Medical mask production equipment and quality rapid detection method of medical mask |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201527389U (en) * | 2009-10-30 | 2010-07-14 | 中国安全生产科学研究院 | Detection device of performance of preventing infiltration of chemicals for relief protective clothing materials |
| GB201311203D0 (en) * | 2013-06-24 | 2013-08-14 | Ind Textiles & Plastics Ltd | Permeability determination |
| CN207336314U (en) * | 2017-10-23 | 2018-05-08 | 中国安全生产科学研究院 | A kind of resistance to liquid chemicals permeance property test system of chemical protecting suit |
| CN208420633U (en) * | 2018-08-01 | 2019-01-22 | 山东省医疗器械产品质量检验中心 | Permeation Test System |
-
2018
- 2018-08-01 CN CN201810862383.1A patent/CN110793897A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201527389U (en) * | 2009-10-30 | 2010-07-14 | 中国安全生产科学研究院 | Detection device of performance of preventing infiltration of chemicals for relief protective clothing materials |
| GB201311203D0 (en) * | 2013-06-24 | 2013-08-14 | Ind Textiles & Plastics Ltd | Permeability determination |
| CN207336314U (en) * | 2017-10-23 | 2018-05-08 | 中国安全生产科学研究院 | A kind of resistance to liquid chemicals permeance property test system of chemical protecting suit |
| CN208420633U (en) * | 2018-08-01 | 2019-01-22 | 山东省医疗器械产品质量检验中心 | Permeation Test System |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111642833A (en) * | 2020-04-22 | 2020-09-11 | 王峰 | Medical mask production equipment and quality rapid detection method of medical mask |
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