CN110787278B - Traditional Chinese medicine external application plaster for treating tenosynovitis and preparation method thereof - Google Patents

Traditional Chinese medicine external application plaster for treating tenosynovitis and preparation method thereof Download PDF

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CN110787278B
CN110787278B CN201911146898.2A CN201911146898A CN110787278B CN 110787278 B CN110787278 B CN 110787278B CN 201911146898 A CN201911146898 A CN 201911146898A CN 110787278 B CN110787278 B CN 110787278B
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叶勇
何根怀
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Abstract

The invention relates to a traditional Chinese medicine external application plaster for treating tenosynovitis and a preparation method thereof, wherein the traditional Chinese medicine external application plaster is prepared from the following raw materials by weight: 6-7 g of prepared tinospora sinensis, 1-4 g of dried ginger, 1.5-2.5 g of eupolyphaga, 3-5 g of prepared aconite root, 1.5-3 g of cassia twig, 1.5-2.5 g of white mustard seed, 8-12 g of quicklime, 20 g of moxa and 8-15 ml of ginger juice. The Chinese medicinal external application at least comprises a quicklime layer, a Chinese medicinal layer and a moxa layer, wherein the Chinese medicinal layer is located above the moxa layer, the quicklime layer is located above the Chinese medicinal layer, the quicklime layer, the Chinese medicinal layer and the moxa layer are wrapped into a medicinal bag by upper and lower sterile pure cotton gauzes, and ginger juice is uniformly coated on one side of the medicinal bag located on the quicklime layer. The invention utilizes the functions of relaxing muscles and tendons and activating collaterals of hot gas and medicaments to promote local blood circulation, enhance local metabolism, improve local nutritional status, release adhesion, smooth joints and promote the recovery of the flexion and extension functions of affected fingers; the invention has the characteristics of moderate hardness, convenient use, no wound, good effect, low price and the like.

Description

Traditional Chinese medicine external application plaster for treating tenosynovitis and preparation method thereof
Technical Field
The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine external application plaster for treating tenosynovitis and a preparation method thereof. Belongs to the field of traditional Chinese medicine.
Background
The tendon sheath is a double-layer sleeve-like closed synovial tube sleeved outside the tendon and is a synovial sheath for protecting the tendon. It is divided into two layers to wrap the tendon, a cavity between the two layers is a synovial cavity, and tendon sheath synovial fluid is arranged in the cavity. The inner layer is tightly adhered to the tendon, and the outer layer is lined in the tendon fiber sheath and combined with the bone surface together, so that the tendon fiber sheath has the functions of fixing, protecting and lubricating the tendon and preventing the tendon from being rubbed or pressed. Aseptic inflammation of tendons and sheaths, caused by various causes, causes swelling, known as tenosynovitis. Tenosynovitis can be classified into tenosynovitis stenosed in flexor tendon, tenosynovitis stenosed in radial styloid process, tenosynovitis in extensor carpi ulnaris, tenosynovitis in flexor tendon in plantar region, etc., and tenosynovitis stenosed in flexor tendon is more common in clinic. If the treatment is not carried out or the treatment is not proper, the life or the work is affected for a long time, and even the permanent activity is inconvenient when the development is carried out.
The traditional Chinese medicine considers that the tenosynovitis is caused by strain injury to the meridians or cold-dampness invading the veins, obstruction of the meridians, unsmooth circulation of qi and blood, qi stagnation and blood stasis. Many methods have been tried, such as massage, external use of anti-inflammatory and analgesic paste, occlusion, small needle knife, surgery, etc. Some are time-consuming, some have wounds, some are not conducive to absorption or some are inconvenient to use, some are costly, and the like.
Disclosure of Invention
The invention aims to overcome the problems in the prior art and provides a traditional Chinese medicine external application for treating tenosynovitis and a preparation method thereof. The plaster of the invention can make inflammation easier to be absorbed, promote the subsidence of edema of the tendon sheath wall and the tendon, relieve joint interlock, relieve pain and recover the function of suffering from flexion and extension; particularly, the Chinese medicinal application paste promotes local blood circulation, enhances local metabolism, improves local nutritional status, releases adhesion, smooths joints and promotes recovery of the flexion and extension functions of affected fingers by virtue of the functions of relaxing tendons and activating collaterals of hot air and medicaments; the plaster has the characteristics of moderate hardness, convenient use, no wound, good effect, low price and the like.
The Chinese medicinal external application plaster can also be used for treating cold-dampness cervical spondylosis, lumbar spondylosis, shoulder joint, elbow and knee joint pain and other diseases.
The traditional Chinese medicine is applied externally; warming tendons and dredging collaterals, resolving hard mass and removing blood stasis to relieve pain.
The technical scheme of the invention is as follows: a traditional Chinese medicine external application plaster for treating tenosynovitis is prepared from the following raw materials by weight: 6-7 g of prepared tinospora sinensis, 1-4 g of dried ginger, 1.5-2.5 g of eupolyphaga, 3-5 g of prepared aconite root, 1.5-3 g of cassia twig, 1.5-2.5 g of white mustard seed, 8-12 g of quicklime, 20 g of moxa and 8-15 ml of ginger juice.
Further, the traditional Chinese medicine external application plaster is prepared from the following raw materials by weight: 6 g of prepared tinospora sinensis, 2 g of dried ginger, 2 g of ground beetle, 4 g of prepared aconite root, 2 g of cassia twig, 2 g of white mustard seed, 10 g of quicklime, 20 g of moxa and 10 ml of ginger juice.
Further, the traditional Chinese medicine external application at least comprises a quicklime layer, a traditional Chinese medicine layer and a moxa layer, wherein the traditional Chinese medicine layer is positioned above the moxa layer, the quicklime layer is positioned above the traditional Chinese medicine layer, the quicklime layer, the traditional Chinese medicine layer and the moxa layer are wrapped into a medicine bag through an upper sterile pure cotton gauze and a lower sterile pure cotton gauze, and one side of the medicine bag positioned on the quicklime layer is uniformly coated with a formula amount of ginger juice, wherein the traditional Chinese medicine layer comprises traditional Chinese medicine raw materials of formula amounts of prepared caulis tinosporae, dried ginger, eupolyphaga, prepared monkshood, cassia twig and white mustard seed; the raw material of the quicklime layer is quicklime with a formula amount; the moxa layer is prepared from moxa according to the formula.
Further, the processing method for preparing the tinospora sinensis includes:
1) weighing the following raw materials in percentage by weight: 100 kg of tinospora sinensis, 30 kg of dried ginger and 12.5 kg of prepared auxiliary pieces;
2) decocting the dried ginger and the prepared radix aconiti lateralis preparata slices for 1 hour, fishing out the dried ginger and the prepared radix aconiti preparata slices, reserving liquid medicine, adding the prepared tinospora sinensis in the liquid medicine, decocting for 25-35 minutes, allowing the tinospora sinensis to absorb the liquid medicine completely, taking out and naturally drying.
Further, a preparation method of the traditional Chinese medicine external application plaster for treating tenosynovitis specifically comprises the following steps:
step 1) material preparation:
weighing 6-7 g of prepared tinospora sinensis, 1-4 g of dried ginger, 1.5-2.5 g of eupolyphaga, 3-5 g of prepared monkshood, 1.5-3 g of cassia twig, 1.5-2.5 g of white mustard seed, 8-12 g of quicklime and 20 g of moxa; taking two pieces of sterile pure cotton gauze and 8-15 ml of ginger juice;
step 2) grinding the white mustard seeds according to the formula amount, and sieving the ground white mustard seeds with a 100-mesh sieve to obtain fine powder for later use;
step 3) drying the prepared tinospora sinensis, eupolyphaga, cassia twig, dried ginger and prepared monkshood according to the formula amount; mixing; pulverizing, sieving with 100 mesh sieve to obtain fine powder, and mixing with the fine powder obtained in step 2); obtaining mixed traditional Chinese medicine powder for later use;
step 4) grinding the quicklime with the formula amount, and sieving the ground quicklime with a 100-mesh sieve to obtain fine powder for later use;
step 5) taking a piece of sterile pure cotton gauze, and uniformly paving a layer of moxa with a formula amount on the sterile pure cotton gauze to form a moxa layer; spreading the traditional Chinese medicine powder obtained in the step 3) on the moxa layer to form a traditional Chinese medicine layer; spreading the quicklime powder obtained in the step 4) on the traditional Chinese medicine layer to form a quicklime layer, covering another piece of sterile pure cotton gauze, and sewing the upper and lower sterile pure cotton gauzes into a medicine bag;
and 6) uniformly coating 8-15 ml of ginger juice on one side of the medicine bag positioned on the quicklime layer.
Further, still include: the side of the medicated bag coated with rhizoma Zingiberis recens juice is provided with non-woven fabric adhesive tape.
Further, the sterile pure cotton gauze is 13 cm multiplied by 10 cm, and the medicine bag is 12 cm multiplied by 9 cm.
The invention has the beneficial effects that: the processed caulis tinosporae sinensis in the plaster has warm nature, and has effects of relaxing muscles and tendons, activating collaterals, warming tendons and relieving pain. The product of dried ginger and prepared monkshood with pungent and hot property enhances the effects of warming tendons and dispelling cold of the prepared tinospora sinensis, and the white mustard seed is used for dispersing accumulation of pathogen and reducing swelling and is matched with the cassia twig for dispelling cold and expelling the muscles, warming and dredging the channels and collaterals and supporting yang and regulating qi; the ginger juice can generate a large amount of heat after being injected into quick lime for dispelling cold, is stored in the moxa for dispelling cold and relieving pain to remove cold evil together, and is added with the eupolyphaga for removing blood stasis and dissipating stagnation and promoting tendon and wound healing to ensure that qi and blood are smooth. The traditional Chinese medicine components in the plaster have the advantages of promoting tissue regeneration, activating blood circulation, resolving hard mass, relieving pain, and enabling damaged tendon sheath swelling to resolve hard mass, relieving pain, and repairing tissues. After the application is formed, the soft and hard of the application is moderate, one side of the affected finger is wrapped by the application through braking, the friction between the flexor tendon and the wall of the sheath tube is limited, the pressure on the metacarpal head is relieved, the thickened tendon sheath tube wall and the expanded tendon inflammatory reaction are relieved, the inflammation is easily absorbed, the edema elimination of the tendon sheath wall and the tendon is promoted, the joint interlocking is relieved, the pain is relieved, and the flexion and extension functions of the affected finger are recovered; on the other hand, the traditional Chinese medicine patch can promote local blood circulation, enhance local metabolism, improve local nutritional status, release adhesion, smooth joint and promote recovery of the flexion and extension functions of affected fingers by means of the functions of relaxing tendons and activating collaterals of hot air and medicines.
The invention also has the following advantages:
1) the patch of the invention can continuously and uniformly permeate the efficacy of the traditional Chinese medicine to the deep tissue to form a high-concentration medicine area on the focus through the warming and heat preservation effects of the medicine, and after the patch is fixed by a breathable non-woven fabric adhesive tape, the warm and heat dissipation effects can reach more than 10 hours, and the heating power is uniform and durable.
2) The plaster consisting of the traditional Chinese medicine components plays a role in soft fixation of the affected limb, is moderate in hardness and convenient to use. Not only can limit the joint movement of the patient, but also can effectively reduce the strain of the affected part.
3) The application of the invention uses the traditional Chinese medicine powder and the moxa, and the moxa and the gauze are separated between the traditional Chinese medicine powder and the skin and do not directly contact the skin, thereby avoiding scald and being safe and reliable.
4) The invention is applied to the skin and is in contact with the sterile gauze and the traditional Chinese medicine bag, and has strong air permeability and difficult allergy.
5) The application of the invention is proved by a large number of clinical tests that the invention has no damage to skin epidermal tissues and subcutaneous tissues, no irritation and no side effect on human body.
6) The patch also has the characteristics of no wound, high cure rate, low price, high patient compliance and the like.
Drawings
FIG. 1 is a diagram illustrating the effect of the structure of the present invention;
fig. 2 is a graph showing the effect of the present invention.
Detailed Description
The present invention will be described in further detail below with reference to the accompanying drawings.
Example 1
A traditional Chinese medicine external application plaster for treating tenosynovitis is prepared from the following raw materials by weight: 6-7 g of prepared tinospora sinensis, 1-4 g of dried ginger, 1.5-2.5 g of eupolyphaga, 3-5 g of prepared aconite root, 1.5-3 g of cassia twig, 1.5-2.5 g of white mustard seed, 8-12 g of quicklime and 20 g of moxa; taking two pieces of sterile pure cotton gauze and 8-15 ml of ginger juice.
Example 2
A traditional Chinese medicine external application plaster for treating tenosynovitis is prepared from the following raw materials by weight: 7 g of prepared tinospora sinensis, 2 g of dried ginger, 2 g of ground beetle, 4 g of prepared aconite root, 2 g of cassia twig, 2 g of white mustard seed, 10 g of quicklime, 20 g of moxa and 10 ml of ginger juice. The formula is more suitable for spring and autumn, peaceful and mild areas and areas with pleasant climate.
Example 3
A traditional Chinese medicine external application plaster for treating tenosynovitis is prepared from the following raw materials by weight: 7 g of prepared tinospora sinensis, 1 g of dried ginger, 2 g of ground beetle, 3 g of prepared aconite root, 1.5 g of cassia twig, 1.5 g of white mustard seed, 8 g of quicklime, 20 g of moxa and 10 ml of ginger juice. The formula is more suitable for summer, damp-heat people and regions with hot climate, and the formula properly reduces the compatibility proportion of the medicines for warming channel, dispelling cold, activating yang and dissipating stagnation.
Example 4
A traditional Chinese medicine external application plaster for treating tenosynovitis is prepared from the following raw materials by weight: 6 g of prepared tinospora sinensis, 4 g of dried ginger, 2 g of ground beetle, 5g of prepared aconite root, 3 g of cassia twig, 2.5 g of white mustard seed, 12 g of quicklime, 20 g of moxa and 10 ml of ginger juice. The formula is more suitable for people with yang deficiency and cold climate areas in winter, and the formula is added with the proportion of the medicines for warming channel, dispelling cold, activating yang and resolving hard mass.
Example 5
A traditional Chinese medicine external application plaster for treating tenosynovitis is prepared from the following raw materials by weight: 7 g of prepared tinospora sinensis, 3 g of dried ginger, 2.5 g of ground beetle, 5g of prepared aconite root, 3 g of cassia twig, 2.5 g of white mustard seed, 12 g of quicklime, 20 g of moxa and 10 ml of ginger juice. The formula is more suitable for patients with blood stasis.
The Chinese medicinal external application can be applied according to different seasons, climates, regional environments and constitutions, and can be applied according to three reasons of time, place and people, so that the medicine is reasonably used.
Example 6
On the basis of any one of the embodiments 1 to 5, as shown in figure 1, the traditional Chinese medicine external application at least comprises a quicklime layer, a traditional Chinese medicine layer and an moxa layer, wherein the traditional Chinese medicine layer is positioned above the moxa layer, the quicklime layer is positioned above the traditional Chinese medicine layer, the quicklime layer, the traditional Chinese medicine layer and the moxa layer are wrapped into a medicine bag by an upper sterile pure cotton gauze and a lower sterile pure cotton gauze, and one side of the medicine bag positioned on the quicklime layer is uniformly coated with a formula amount of ginger juice, wherein the traditional Chinese medicine raw materials of the traditional Chinese medicine layer comprise formula amounts of prepared caulis tinosporae, dried ginger, eupolyphaga sinensis, prepared monkshood, cassia twig and white mustard seed; the raw material of the quicklime layer is quicklime with a formula amount; the moxa layer is prepared from moxa according to the formula.
Further, the processing method for preparing the tinospora sinensis includes:
1) weighing the following raw materials in percentage by weight: 100 kg of tinospora sinensis, 30 kg of dried ginger and 12.5 kg of prepared auxiliary pieces;
2) decocting the dried ginger and the prepared radix aconiti lateralis preparata slices for 1 hour, fishing out the dried ginger and the prepared radix aconiti preparata slices, reserving liquid medicine, adding the prepared tinospora sinensis in the liquid medicine, decocting for 25-35 minutes, allowing the tinospora sinensis to absorb the liquid medicine completely, taking out and naturally drying.
The caulis tinosporae sinensis water extract has analgesic, antiinflammatory, and repercussive effects; the action mechanism of the medicine is probably that the release of inflammatory substances is reduced by reversing cytokines such as TNF-alpha, IL-I beta, IL-6 and the like, thereby playing the roles of easing pain and resisting inflammation[1]. The processed tinospora sinensis is warm in nature, has the functions of eliminating swelling, relieving pain, warming tendon and dredging meridian, and has unique curative effect on tenosynovitis thickened tendon sheath wall, enlarged tendon inflammatory reaction and pain caused by the inflammation reaction.
Example 7
A preparation method of a traditional Chinese medicine external application plaster for treating tenosynovitis specifically comprises the following steps:
step 1) material preparation:
weighing 6-7 g of prepared tinospora sinensis, 1-4 g of dried ginger, 1.5-2.5 g of eupolyphaga, 3-5 g of prepared monkshood, 1.5-3 g of cassia twig, 1.5-2.5 g of white mustard seed, 8-12 g of quicklime and 20 g of moxa; taking two pieces of sterile pure cotton gauze and 8-15 ml of ginger juice;
step 2) grinding the white mustard seeds according to the formula amount, and sieving the ground white mustard seeds with a 100-mesh sieve to obtain fine powder for later use;
step 3) drying the ground beetles, the cassia twig, the dried ginger and the prepared monkshood according to the formula amount; mixing; pulverizing, sieving with 100 mesh sieve to obtain fine powder, and mixing with the fine powder obtained in step 2); obtaining mixed traditional Chinese medicine powder for later use;
step 4), grinding the quicklime with the formula amount, and sieving the ground quicklime with a 100-mesh sieve to obtain fine powder for later use;
step 5) taking a piece of sterile pure cotton gauze, and uniformly paving a layer of moxa with a formula amount on the sterile pure cotton gauze to form a moxa layer; spreading the traditional Chinese medicine powder obtained in the step 3) on the moxa layer to form a traditional Chinese medicine layer; spreading the quicklime powder obtained in the step 4) on the traditional Chinese medicine layer to form a quicklime layer, covering another piece of sterile pure cotton gauze, and sewing the upper and lower sterile pure cotton gauzes into a medicine bag;
and 6) uniformly coating 8-15 ml of ginger juice on one side of the medicine bag positioned on the quicklime layer.
Further, still include: the side of the medicated bag coated with rhizoma Zingiberis recens juice is provided with non-woven fabric adhesive tape.
Further, the processing method for preparing the tinospora sinensis includes:
1) weighing the following raw materials in percentage by weight: 100 kg of tinospora sinensis, 30 kg of dried ginger and 12.5 kg of prepared auxiliary pieces;
2) decocting the dried ginger and the prepared radix aconiti lateralis preparata slices for 1 hour, fishing out the dried ginger and the prepared radix aconiti preparata slices, reserving liquid medicine, adding the prepared tinospora sinensis in the liquid medicine, decocting for 25-35 minutes, allowing the tinospora sinensis to absorb the liquid medicine completely, taking out and naturally drying.
The application method of the traditional Chinese medicine external application comprises the following steps:
disinfecting skin of affected part with 75% alcohol, and uniformly coating 8-15 ml of rhizoma Zingiberis recens juice on one side of the medicinal bag located on the quicklime layer; then, the sterile pure cotton gauze on one side with the moxa layer is longitudinally pasted on the tendon with the tenosynovitis, and the middle point of the pasting aligns to the pressure pain point of the tenosynovitis; finally, the affected limb is wrapped and fixed by a non-woven fabric adhesive tape. The replacement was performed once in 24 hours.
(see FIG. 2)
Preferably, the ginger juice is 10 ml; the sterile pure cotton gauze is 13 cm multiplied by 10 cm, and the medicine bag is 12 cm multiplied by 9 cm. The moxa is pure and soft moxa.
Pharmacodynamic tests and clinical tests are carried out to show the application of the external application of the traditional Chinese medicine for treating tenosynovitis in preparing medicines for treating tenosynovitis caused by non-bacteria and tuberculosis and the treatment effect.
Pharmacodynamic test of the present invention
1) Anti-inflammatory research is carried out, 15 New Zealand white rabbits (divided into a normal group, a model group and a medicine group) are adopted in the experiment, carrageenan is injected into the toe joints of the white rabbits to cause toe joint lesion models, then the medicine group (example 7) applied with the plaster is adopted, after skin absorption, and observation is carried out after 5 days after administration, and the absolute value, the swelling rate and the swelling inhibition rate of the white rabbits applied with the plaster are not increased; through comparison among the normal group, the model group and the drug group 3, the difference has statistical significance (P is less than 0.05), the TNF-alpha level of the rabbit toe joint of the drug group applied by the invention is remarkably reduced, and the effect of the application of the invention on treating synovitis in the toe joint is proved to be good.
2) In the anaphylaxis research, 30 Kunming mice are used in experiments, and the mice are divided into 3 groups by taking partial unhairing, namely a control group 1 (injected with normal saline), a control group 2 (injected with Zhengqing Fengtongning injection according to the specified dose) and a medicine group (adopting the plaster of the invention) at random. The application observation is carried out once every 2, 6 and 12 hours, and the skin has the allergic reactions such as abnormality, asthma and unstable standing. After 3 days of medication test, the result shows that the injection zhengqing fengtongning injection has anaphylactic reaction, but the medicine group adopting the plaster of the invention has no anaphylactic reaction.
Clinical study of the invention
1. General data
190 narrow tenosynovitis patients who were accepted by the department of health of Jinkui Central health institute, Weinan City, Weinan, Shanxi, 4-2019, 3-month in Shaanxi, and Shuangquan health institute, Dali county, Weinan, Shanxi, were selected as the subjects of study. Understand the purpose of the study and sign informed consent.
The test group was divided into an observation group and a control group according to the random number table method. The observation groups of 95 cases (excluding bacterial and tuberculosis infection) are all outpatient patients. Among them, 33 men and 62 women; the age is 28-58 years, and the average age (44.3 +/-10.3) years; the course of disease is 1-11 months, and the average course of disease (6.9 +/-2.0) years. Control group 95, male 41, female 54; the age is 27-58 years, and the average age (42.8 +/-8.8) years; the course of disease is 1-11 months, and the mean course of disease (6.8 + -2.0) years old. There was no significant difference (p >0.05) between the two general data sets.
2. Basis of diagnosis
The standard for the curative effect of diagnosing the disease symptoms of the traditional Chinese medicine (the standard in the pharmaceutical industry of the people's republic of China) published by the national administration of traditional Chinese medicine of 28 th 6 th month in 1994, the standard for the curative effect of diagnosing the disease symptoms of the orthopedics and traumatology of the traditional Chinese medicine, tenosynovitis stenotrophis of the radial styloid process on page 196 and tenosynovitis stenotrophis of the flexor tendon on page 198. Combine "clinical practice guide-bone science separate book" (compiled by the institute of medical science, people's health publishing agency) and "surgical science (the next book) (Special-purpose for clinical medicine of textbook manufactured in 8 years and 7 years, people's health publishing agency). Meanwhile, refer to the clinical research guiding principle of new Chinese medicine for treating soft tissue injury, page 121 of orthopedics, which is published by the Ministry of health of the people's republic of China in 5 months of 1993 in the third edition.
3. Criteria for judging curative effect of case
According to the standard of curative effect for diagnosing the disease of the traditional Chinese medicine (the standard of the pharmaceutical industry in the people's republic of China) published by the national administration of traditional Chinese medicine of 28-6-month in 1994, the standard of curative effect for diagnosing the disease of the orthopedics and traumatology in of the traditional Chinese medicine, stenosing tenosynovitis of the radial styloid process on page 196 and stenosing tenosynovitis of the flexor tendon on page 198. Refer to the standard for determining therapeutic effect in the "clinical research guideline for treating soft tissue injury with new Chinese medicine" on page 121 of orthopedics, third edition of the "clinical research guideline for new Chinese medicine" formulated by Ministry of health of the people's republic of China in 5 months 1993.
Tenosynovitis stenosa of flexor tendon
Curing; the side of the finger and palm has no swelling pain, no pressure pain, normal bending and stretching activities, no spring sound and no interlocking phenomenon.
The method is effective; the local swelling and pain is relieved, and slight pain or spring sound is still generated during the activity, but the interlocking phenomenon is not generated.
Invalid; no improvement in symptoms.
Stenosing tenosynovitis of styloid process of radius
Curing; the pain and tenderness on the radial side of the wrist disappear, the function recovers, and the test on deviation of fist and ulnar is negative.
The method is effective; pain in the wrist, slight pain during movement, oblique fisting and ulnar deviation test (+/-).
Invalid; no improvement in symptoms.
4. Exclusion criteria
Removing tendon sheath diseases caused by historical bone injury patients, chilblain patients, operation patients, bacteria and tuberculosis infection.
5. Comparison method
The control group patients were given topical block therapy of lidocaine + prednisolone at doses of 2ml (0.05g) and 12.5mg, once a week for three weeks.
The observation group used the Chinese medicinal external application of the present invention (see example 7 for the specific preparation method and application method).
6. Observation method
A statistical method is adopted; the measurement data is expressed by mean plus minus standard deviation
(x-S), the mean value comparison between two groups adopts two independent samples to carry out t/t' test; self-contrast mean value comparison, adopt and pair t test. The count data is compared with the rank data by frequency (f), composition ratio (P) and average rank (R)-) Indicated, Mann-Whitney U test was used. Comparing the two groups of percentages by Fisher chi2Checking; data statistics were performed by the sps 19.0 statistics software. α is 0.05.
Results
1) The total effective rate of the observation group is 96.8%, the total effective rate of the control group is 90.5%, and the total effective rate of the observation group is obviously higher than that of the control group (P <0.05), which is shown in table 1.
Table 1 shows the comparison of the clinical efficacy of two groups (f, R)-,P)
Figure BDA0002282447960000111
Note: compared with the control group, P is less than 0.05
2) VAS score
Before treatment, the VAS scores of the two groups of patients differed statistically (P > 0.05). After treatment, VAS scores were significantly lower in both groups than before treatment (P <0.05), and post-treatment VAS scores were significantly lower in the observation group than in the control group (P <0.05), see table 2.
Table 2 compares VAS scores for two groups of patients (x)-S, minutes)
Figure BDA0002282447960000112
Note: compared with the pretreatment, the P is less than 0.05; p <0.05 in comparison with the control group
3) Recurrence rate of the condition
The observation group had a recurrence rate of 1% and the control group had a recurrence rate of 15% at half a year follow-up. The observed group had significantly lower relapse rates than the control group (P <0.05), see table 3.
TABLE 3 comparison of relapse rates in two groups of patients (f, P)
Figure BDA0002282447960000113
Note: compared with the control group, P is less than 0.05
7. Adverse reaction
The 95 patients in the observation group are applied continuously for 14 days according to the treatment course without rash, pruritus, heart, liver, kidney and other organ damage.
In the experiment, 95 cases of patients who are complete (14 days after continuous use of the application, replacement of the application every 24 hours, and proper activity of the affected knuckles when the application is replaced) are recorded by the observation group, and the application has good treatment effect on stenosing tenosynovitis caused by non-bacteria and tuberculosis. The symptoms of swelling, bounce, interlock and the like caused by tenosynovitis gradually disappear after use. And cause the signs caused by tenosynovitis such as: the pain of pressing and the deviation of the fist-making ruler are gradually turned into yin. The patient's joint bending and stretching activities become increasingly normal.
8. Typical cases
In case 1, the woman is 54 years old, the housewife has tenosynovitis for more than 2 years, the left thumb is painful, the hand cannot be close to the woman, the palm side of the thumb is swollen near the jaw, a nodule of 1.2 cm multiplied by 1.0 cm is touched, and the pain of the fingers is aggravated by passive movement and the fingers have interlocking and bounce. Go to a hospital for examination, and recommend surgical treatment, and remove the thickened synovium and fascia. Because of fear of operation pain and longer postoperative recovery time, the patient can see a doctor by visiting the department, and the application is used for treatment, the patient can be replaced once in 24 hours, the swelling subsides in 4 days, the tubercle on the palm side of the thumb, which is close to the first web, is 0.5 cm multiplied by 0.5 cm, and the pain (+) is pressed. The product is continuously used for 10 days, and the medicine is stopped. After 6 months of follow-up visit, the left thumb has no symptoms such as swelling, bounce, interlocking and the like, and the palm side of the left thumb has no pressure pain near the tiger's mouth and has good mobility.
Case 2, ruan, man, a welder in a company, suffered from tenosynovitis for more than 1 year, suffered from pain in the left thumb, and failed to flex and stretch, and was released by the small needle knife in a hospital in a county. After the operation, the left hand has large interstocks of the fish, swollen fingers of the left hand, 1.0 cm multiplied by 1.0 cm of nodules on the palm side of the thumb close to the first web, tenderness (+), interlocking, tenderness and no bounce of the fingers. The product is continuously used for 14 days, and the medicine is stopped. After 6 months of follow-up visit, the left thumb has no symptoms such as swelling, bounce, interlocking and the like, and the palm side of the left thumb has no pressure pain near the tiger's mouth and has good mobility.
The parts of the present embodiment not described in detail are common means known in the art, and are not described here. The above examples are merely illustrative of the present invention and should not be construed as limiting the scope of the invention, which is intended to be covered by the claims and any design similar or equivalent to the scope of the invention.

Claims (6)

1. A traditional Chinese medicine external application plaster for treating tenosynovitis is characterized in that: the traditional Chinese medicine external application plaster is prepared from the following raw materials by weight: 6-7 g of prepared tinospora sinensis, 1-4 g of dried ginger, 1.5-2.5 g of eupolyphaga, 3-5 g of prepared monkshood, 1.5-3 g of cassia twig, 1.5-2.5 g of white mustard seed, 8-12 g of quicklime, 20 g of moxa and 8-15 ml of ginger juice; the Chinese medicinal external application at least comprises a quicklime layer, a Chinese medicinal layer and a moxa layer, wherein the Chinese medicinal layer is positioned above the moxa layer, the quicklime layer is positioned above the Chinese medicinal layer, the quicklime layer, the Chinese medicinal layer and the moxa layer are wrapped into a medicine bag by upper and lower sterile pure cotton gauzes, and one side of the medicine bag positioned on the quicklime layer is uniformly coated with ginger juice according to the formula amount, wherein the Chinese medicinal material in the Chinese medicinal layer is prepared from prepared caulis tinosporae, rhizoma Zingiberis, Eupolyphaga Seu Steleophaga, radix Aconiti lateralis Preparata, ramulus Cinnamomi and semen Sinapis Albae according to the formula amount; the raw material of the quicklime layer is quicklime with a formula amount; the moxa layer is prepared from moxa according to the formula.
2. The external application of traditional Chinese medicine for treating tenosynovitis as claimed in claim 1, which is characterized in that: the traditional Chinese medicine external application plaster is prepared from the following raw materials by weight: 6 g of prepared tinospora sinensis, 2 g of dried ginger, 2 g of ground beetle, 4 g of prepared aconite root, 2 g of cassia twig, 2 g of white mustard seed, 10 g of quicklime, 20 g of moxa and 10 ml of ginger juice.
3. The preparation method of the external traditional Chinese medicine application for treating tenosynovitis according to any one of claims 1 or 2, which is characterized in that: the processing method for preparing the tinospora sinensis includes:
1) weighing the following raw materials in percentage by weight: 100 kg of tinospora sinensis, 30 kg of dried ginger and 12.5 kg of prepared auxiliary pieces;
2) decocting the dried ginger and the prepared radix aconiti lateralis preparata slices for 1 hour, fishing out the dried ginger and the prepared radix aconiti preparata slices, reserving liquid medicine, adding the prepared tinospora sinensis in the liquid medicine, decocting for 25-35 minutes, allowing the tinospora sinensis to absorb the liquid medicine completely, taking out and naturally drying.
4. The preparation method of the external traditional Chinese medicine application for treating tenosynovitis as claimed in claim 1, which is characterized in that: the method specifically comprises the following steps:
step 1) material preparation:
weighing 6-7 g of prepared tinospora sinensis, 1-4 g of dried ginger, 1.5-2.5 g of eupolyphaga, 3-5 g of prepared monkshood, 1.5-3 g of cassia twig, 1.5-2.5 g of white mustard seed, 8-12 g of quicklime and 20 g of moxa; taking two pieces of sterile pure cotton gauze and 8-15 ml of ginger juice;
step 2) grinding the white mustard seeds according to the formula amount, and sieving the ground white mustard seeds with a 100-mesh sieve to obtain fine powder for later use;
step 3) drying the prepared tinospora sinensis, eupolyphaga, cassia twig, dried ginger and prepared monkshood according to the formula amount; mixing; pulverizing, sieving with 100 mesh sieve to obtain fine powder, and mixing with the fine powder obtained in step 2); obtaining mixed traditional Chinese medicine powder for later use;
step 4) grinding the quicklime with the formula amount, and sieving the ground quicklime with a 100-mesh sieve to obtain fine powder for later use;
step 5) taking a piece of sterile pure cotton gauze, and uniformly paving a layer of moxa with a formula amount on the sterile pure cotton gauze to form a moxa layer; spreading the traditional Chinese medicine powder obtained in the step 3) on the moxa layer to form a traditional Chinese medicine layer; spreading the quicklime powder obtained in the step 4) on the traditional Chinese medicine layer to form a quicklime layer, covering another piece of sterile pure cotton gauze, and sewing the upper and lower sterile pure cotton gauzes into a medicine bag;
and 6) uniformly coating 8-15 ml of ginger juice on one side of the medicine bag positioned on the quicklime layer.
5. The preparation method of the external traditional Chinese medicine application for treating tenosynovitis as claimed in claim 4, which is characterized in that: further comprising: the side of the medicated bag coated with rhizoma Zingiberis recens juice is provided with non-woven fabric adhesive tape.
6. The preparation method of the external traditional Chinese medicine application for treating tenosynovitis as claimed in claim 4, which is characterized in that: the sterile pure cotton gauze is 13 cm multiplied by 10 cm, and the medicine bag is 12 cm multiplied by 9 cm.
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CN101804190A (en) * 2010-04-26 2010-08-18 丁荣松 Tongbi cream for relieving rigidity of muscles and promoting blood circulation and preparation method thereof
CN104706782A (en) * 2015-02-12 2015-06-17 杨德重 External tincture for treating bone poliomyelitis and preparation method of external tincture
CN105395890A (en) * 2015-12-17 2016-03-16 王福梅 Traditional Chinese medicine preparation used for treating extensor carpi tenosynovitis
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