CN110786963A - Composite heart or blood vessel patch - Google Patents
Composite heart or blood vessel patch Download PDFInfo
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- CN110786963A CN110786963A CN201911162206.3A CN201911162206A CN110786963A CN 110786963 A CN110786963 A CN 110786963A CN 201911162206 A CN201911162206 A CN 201911162206A CN 110786963 A CN110786963 A CN 110786963A
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- fabric reinforcing
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- blood blocking
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- 239000002131 composite material Substances 0.000 title claims abstract description 19
- 210000004204 blood vessel Anatomy 0.000 title abstract description 17
- 239000008280 blood Substances 0.000 claims abstract description 44
- 210000004369 blood Anatomy 0.000 claims abstract description 44
- 230000000903 blocking effect Effects 0.000 claims abstract description 36
- 239000004744 fabric Substances 0.000 claims abstract description 36
- 230000003014 reinforcing effect Effects 0.000 claims abstract description 31
- 229920001971 elastomer Polymers 0.000 claims abstract description 22
- 239000000806 elastomer Substances 0.000 claims abstract description 22
- 230000001965 increasing effect Effects 0.000 claims abstract description 7
- 230000007423 decrease Effects 0.000 claims abstract description 3
- 239000011148 porous material Substances 0.000 claims description 23
- 239000000463 material Substances 0.000 claims description 13
- 230000002792 vascular Effects 0.000 claims description 13
- -1 polytetrafluoroethylene Polymers 0.000 claims description 12
- 239000000835 fiber Substances 0.000 claims description 11
- 230000000747 cardiac effect Effects 0.000 claims description 10
- 239000002121 nanofiber Substances 0.000 claims description 7
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 7
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 7
- 229920002635 polyurethane Polymers 0.000 claims description 7
- 239000004814 polyurethane Substances 0.000 claims description 7
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 238000009941 weaving Methods 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 2
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920006306 polyurethane fiber Polymers 0.000 claims description 2
- 230000002787 reinforcement Effects 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 claims 1
- 230000002785 anti-thrombosis Effects 0.000 abstract description 7
- 239000003146 anticoagulant agent Substances 0.000 abstract description 2
- 230000010261 cell growth Effects 0.000 abstract description 2
- 230000035699 permeability Effects 0.000 abstract description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 238000009940 knitting Methods 0.000 description 4
- 229920000728 polyester Polymers 0.000 description 4
- 230000008439 repair process Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
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- 208000001910 Ventricular Heart Septal Defects Diseases 0.000 description 2
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
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- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 208000002330 Congenital Heart Defects Diseases 0.000 description 1
- 229920004934 Dacron® Polymers 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 208000035478 Interatrial communication Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 230000001746 atrial effect Effects 0.000 description 1
- 208000013914 atrial heart septal defect Diseases 0.000 description 1
- 206010003664 atrial septal defect Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
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- 230000004888 barrier function Effects 0.000 description 1
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- 150000001875 compounds Chemical class 0.000 description 1
- 208000028831 congenital heart disease Diseases 0.000 description 1
- 238000011549 displacement method Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- 201000011066 hemangioma Diseases 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
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- 210000003516 pericardium Anatomy 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
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- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
- A61F2002/0086—Special surfaces of prostheses, e.g. for improving ingrowth for preferentially controlling or promoting the growth of specific types of cells or tissues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Materials For Medical Uses (AREA)
- Dispersion Chemistry (AREA)
Abstract
The invention discloses a composite heart or blood vessel patch, which comprises a blood blocking layer, an elastomer layer and a fabric reinforcing layer, wherein the blood blocking layer is the inner surface of the patch, the fabric reinforcing layer is the outer surface of the patch, and the elastomer layer is positioned between the blood blocking layer and the fabric reinforcing layer; micropores are distributed on the blood blocking layer, the elastomer layer and the fabric reinforcing layer, and the sizes of the micropores are gradually increased from the blood blocking layer to the fabric reinforcing layer. The heart or blood vessel patch provided by the invention has good permeability resistance, antithrombotic property, biocompatibility and mechanical property; the blood blocking performance, the tissue ingrowth performance, the antithrombotic performance, the mechanical strength and the thickness of each layer are in gradient change, and the blood blocking performance is in an increasing trend from the outer layer to the inner layer; the cell growth performance is reduced from the outer layer to the inner layer; antithrombotic property, which is enhanced from the outer layer to the inner layer; the mechanical strength, from the outer layer to the inner layer, tends to decrease.
Description
Technical Field
The invention relates to a composite heart or blood vessel patch, and belongs to the technical field of medical materials.
Background
The heart patch is a consumable commonly used in surgeries such as congenital heart disease and the like, is used for repairing ventricular diseases such as ventricular septal defect and ventricular wall repair of the heart, is also commonly applied to the repair surgeries of the atrial diseases such as atrial septal defect and the like, can be randomly cut according to the defect condition, and is also commonly used as a suture gasket for various surgeries. The vascular patch is used for repairing a fistula of a blood vessel caused by hemangioma, angiostenosis and the like, generally the vascular patch is required to have the characteristics of easiness in suture, easiness in hemostasis and the like, and the common aortic and carotid artery repair is more in application. Although the material of the human body is the most ideal material of the cardiac and vascular patch for the operation, the source of the material is very limited, and the material can not meet the requirement of the medical operation basically.
Various problems still exist with the patches that are currently commercialized. For example, after the dacron patch is used for ventricular septal defect or vascular repair, once residual leakage occurs after operation, hemolysis, bacterial or fungal infection can be easily caused; in addition, the elasticity of the polyester patch is reduced after the polyester patch is soaked in normal saline or blood, and the polyester patch is easy to leak blood due to micropores between polyester fibers. The polytetrafluoroethylene patch is easy to form needle holes at the sewing position, which causes blood leakage. The bovine pericardium patch has the problems of easy calcification and the like.
Disclosure of Invention
The purpose is as follows: in order to overcome the defects in the prior art, the invention provides a composite heart or blood vessel patch, overcomes the defect that the existing patch is easy to leak blood, and solves the technical problems of improving the biocompatibility and the impermeability of the patch, and enhancing the flexibility and the suture strength of the patch.
The technical scheme is as follows: in order to solve the technical problems, the technical scheme adopted by the invention is as follows:
a composite heart or blood vessel patch comprises a blood blocking layer, an elastomer layer and a fabric reinforcing layer, wherein the blood blocking layer is the inner surface of the patch, the fabric reinforcing layer is the outer surface of the patch, and the elastomer layer is positioned between the blood blocking layer and the fabric reinforcing layer; micropores are distributed on the blood blocking layer, the elastomer layer and the fabric reinforcing layer, and the sizes of the micropores are gradually increased from the inner surface to the outer surface of the patch.
Furthermore, the blood blocking layer is prepared by mixing one or more of expanded polytetrafluoroethylene, polytetrafluoroethylene nano-fibers and polyurethane nano-fibers, has good blood compatibility, is not easy to form thrombus and has good antithrombotic property.
Furthermore, the porosity of the blood blocking layer is 10% -80%, and the average pore diameter of micropores on the blood blocking layer is 0.1-10 μm. The pores can reduce the weight of the patch, the smaller pore diameter can ensure the blood blocking performance of the patch, so that blood does not seep during and after operation, and the existence of the micropores is also beneficial to the adhesion of endothelial cells on the inner surface of the patch.
Furthermore, the elastomer layer is prepared by mixing one or more materials of microporous silica gel, microporous polyurethane and polyurethane nanofiber, has good elasticity, and makes the patch have good flexibility.
Furthermore, the porosity of the elastomer layer is 20% -90%, and the average pore diameter of micropores on the elastomer layer is 0.5-100 μm. The pores can reduce the weight of the patch, the pore diameter is not suitable to be too large, and the pore diameter is not favorable for keeping good elasticity of the middle layer; the average pore size is 0.5-100 microns, so that human cells can grow into the middle layer from the outer surface of the patch in a three-dimensional manner or can be adhered to the junction of the outer surface and the middle layer.
Further, the fabric reinforcing layer is woven by one or more materials of polyethylene terephthalate fiber, silk, polyurethane fiber, polypropylene fiber, polyethylene fiber or polytetrafluoroethylene fiber, and the weaving process includes, but is not limited to, warp knitting, weft knitting, weaving and knitting.
Further, the porosity of the fabric reinforcing layer is 30% -70%, the average pore diameter of micropores on the fabric reinforcing layer is 20-200 μm, and cells and tissue fluid in the pore diameter range can penetrate from the outer surface of the patch in a three-dimensional mode.
Furthermore, the thickness of the blood blocking layer is 10-300 μm, so that the blood blocking performance can be ensured; the thickness of the elastomer layer is 35-800 microns, so that the patch is not too thick under the condition of ensuring the flexibility of the patch; the thickness of the fabric reinforcing layer is 40-900 microns, so that the patch is ensured to have enough strength, and meanwhile, the patch is not too thick. The thickness gradually decreases from the fabric reinforcing layer to the blood blocking layer, namely the outer fabric reinforcing layer is thickest, the middle layer elastic body is next to the middle layer elastic body, and the inner blood blocking layer is smallest in thickness.
Furthermore, the patch is 400-1600 microns thick and is larger than 400 microns thick, so that the strength of the patch is ensured, the patch cannot be damaged due to insufficient strength when the patch is used in a body, and secondary damage to a patient is avoided; the thickness is less than 1600 μm, the patch is not too thick under the condition of ensuring the basic performance, and the patch is a foreign body in the body, so the too thick patch can cause discomfort to the patient and is not beneficial to suture.
Has the advantages that: the compound heart or blood vessel patch provided by the invention is composed of the blood blocking layer, the elastomer layer and the fabric reinforcing layer, wherein the blood blocking layer is used as the inner surface of the heart or blood vessel patch, so that the patch does not bleed during and after operation and has good antithrombotic performance; the elastic body layer is used as the patch middle layer, so that the patch has good flexibility, and the elastic body layer can play a role in bonding the inner surface and the outer surface of the patch; the fabric obtained by fiber textile processing is used as the outer surface of the heart or blood vessel patch, so that the patch has good suture strength, and the larger aperture on the fabric reinforcing layer can enable cells and tissue fluid to three-dimensionally permeate into the outer surface of the patch, so that the tissue is better fused into a whole. The composite heart or blood vessel patch has good biocompatibility, no blood seepage, good antithrombotic property, good flexibility and high suture strength, and the proper pore size distribution is that cells can grow in the patch in three dimensions, thereby promoting the integration of the prosthesis of the patch and surrounding human tissues. The heart or blood vessel patch can be widely applied in the field of cardiovascular, and has high economic benefit and good application prospect.
Drawings
Fig. 1 is a schematic cross-sectional structure of the present invention.
Detailed Description
The present invention will be further described with reference to the accompanying drawings.
As shown in fig. 1, the composite heart or blood vessel patch comprises a blood blocking layer 1, an elastomer layer 2 and a fabric reinforcing layer 3, wherein the blood blocking layer 1 is the inner surface of the patch, the fabric reinforcing layer 3 is the outer surface of the patch, and the elastomer layer 2 is positioned between the blood blocking layer 1 and the fabric reinforcing layer 3; micropores are distributed on the blood blocking layer 1, the elastomer layer 2 and the fabric reinforcing layer 3, and the sizes of the micropores are gradually increased from the inner surface to the outer surface of the patch.
The patch has an increasing tendency to block blood flow from the outer surface to the inner surface; the cell growth performance of the patch is reduced from the outer surface to the inner surface; the antithrombotic property of the patch is increased from the outer surface to the inner surface.
The specifications of the patch are as follows: 6mm × 100mm, 8mm × 75mm, 10mm × 90mm, 20mm × 140mm, 50 × 75 mm.
Example one
A composite heart or blood vessel patch has a size of 20mm × 140mm, and a thickness of 565 μm; the patch thickness refers to the total thickness of the dense blood barrier layer 1, the elastomer layer 2, and the fabric reinforcement layer 3.
The inner layer blood blocking layer 1 is made of polytetrafluoroethylene nano fibers, the thickness is 144 mu m, the porosity is 82%, and the average pore diameter is 0.9 mu m.
The middle layer elastomer layer 2 was a microporous polyurethane layer with a thickness of 205 μm, a porosity of 50% and an average pore diameter of 40 μm.
The outer fabric reinforcing layer is a fabric formed by warp knitting processing of 3-position silk, the thickness is 216 mu m, the porosity is 52%, and the average pore diameter is 150 mu m.
The thickness of the patch and the thickness of each layer of the patch are measured by a thickness gauge under the conditions that the pressure is 17.5kPa and the area of a presser foot is 50mm2Testing under the conditions to obtain: one point was measured every 2cm in the transverse and longitudinal directions for a total of 5 points, and all the measurement points were averaged.
The porosity of each layer of the patch was tested by the liquid displacement method: using ethanol as a displacement fluid, the material is placed in a known volume V1In ethanol solution, after 10 minutes, the volume of mixture V of ethanol and material was recorded2The material was removed from the ethanol solution and the volume V of the remaining ethanol solution was recorded3The porosity ρ of the material is calculated according to the following formula: ρ (%) = [ (V)1-V3)/(V2-V3)]*100%。
The pore diameter of each layer of the patch is measured by a PMI (PMI pore diameter indicator), and specifically comprises the following steps: shearing a sample to be measured into a circle with the diameter of about 1.5cm, wetting the sample with a wetting liquid, and then putting the sample into an adaptive disc; and sealing, opening an air inlet valve, introducing air into the test box, opening the maximum aperture (or called bubble point aperture) of the sample along with the increase of pressure, then opening smaller and smaller apertures, displaying a dry curve and a wet curve on a test interface, taking one half of the numerical value of each point on the dry curve to form a semi-dry curve, and calculating the average aperture according to the pressure value at the intersection point of the semi-dry curve and the corresponding wet curve.
Testing of patch water permeability: fixing the patch on a water seepage instrument, opening a water valve of the water seepage instrument after the water pressure reaches (16.0 +/-0.3) kPa, and measuring the volume of water seeped from the patch within 10 min. The heart or blood vessel patch prepared in this example had a water penetration of 0 at 16 kPa.
Example two
A composite heart or blood vessel patch has a size of 50mm × 75mm, and a thickness of 684 μm.
The inner layer blood blocking layer is expanded polytetrafluoroethylene (ePTFE), the thickness is 153 μm, the porosity is 75%, and the average pore diameter is 20 μm.
The middle layer elastomer layer was microporous silica gel with a thickness of 211 μm, a porosity of 51% and an average pore diameter of 30 μm.
The outer fabric reinforcing layer is made of polytetrafluoroethylene fiber warp-knitted fabric, the thickness is 320 mu m, the porosity is 45%, and the average pore diameter is 154 mu m.
The patch thickness and the thickness of each layer of the patch, the porosity and the average pore size were measured in the same manner as in example one.
The above description is only of the preferred embodiments of the present invention, and it should be noted that: it will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the principles of the invention and these are intended to be within the scope of the invention.
Claims (9)
1. A composite cardiac or vascular patch characterized by: the patch comprises a blood blocking layer, an elastic body layer and a fabric reinforcing layer, wherein the blood blocking layer is the inner surface of the patch, the fabric reinforcing layer is the outer surface of the patch, and the elastic body layer is positioned between the blood blocking layer and the fabric reinforcing layer; micropores are distributed on the blood blocking layer, the elastomer layer and the fabric reinforcing layer, and the sizes of the micropores are gradually increased from the inner surface to the outer surface of the patch.
2. A composite cardiac or vascular patch as claimed in claim 1, characterized in that: the blood blocking layer is prepared by mixing one or more materials of expanded polytetrafluoroethylene, polytetrafluoroethylene nano-fibers and polyurethane nano-fibers.
3. A composite cardiac or vascular patch as claimed in claim 2, wherein: the porosity of the blood blocking layer is 10% -80%, and the average pore diameter of micropores on the blood blocking layer is 0.1-10 μm.
4. A composite cardiac or vascular patch as claimed in claim 1, characterized in that: the elastomer layer is prepared by mixing one or more materials of microporous silica gel, microporous polyurethane and polyurethane nanofiber.
5. A composite cardiac or vascular patch as claimed in claim 4, in which: the porosity of the elastomer layer is 20% -90%, and the average pore diameter of micropores on the elastomer layer is 0.5-100 μm.
6. A composite cardiac or vascular patch as claimed in claim 1, characterized in that: the fabric reinforcing layer is formed by weaving one or more materials of polyethylene glycol terephthalate fibers, silk, polyurethane fibers, polypropylene fibers, polyethylene fibers or polytetrafluoroethylene fibers.
7. A composite cardiac or vascular patch as claimed in claim 6, wherein: the porosity of the fabric reinforcing layer is 30% -70%, and the average pore diameter of micropores on the fabric reinforcing layer is 20-200 μm.
8. A composite cardiac or vascular patch as claimed in claim 1, characterized in that: the thickness of the blood blocking layer is 10-300 mu m, the thickness of the elastomer layer is 35-800 mu m, and the thickness of the fabric reinforcing layer is 40-900 mu m; the thickness gradually decreases from the fabric reinforcement layer to the blood blocking layer.
9. A composite cardiac or vascular patch as claimed in claim 8, wherein: the thickness of the patch is 400-1600 mu m.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911162206.3A CN110786963A (en) | 2019-11-25 | 2019-11-25 | Composite heart or blood vessel patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911162206.3A CN110786963A (en) | 2019-11-25 | 2019-11-25 | Composite heart or blood vessel patch |
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| Publication Number | Publication Date |
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| CN110786963A true CN110786963A (en) | 2020-02-14 |
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| CN201911162206.3A Pending CN110786963A (en) | 2019-11-25 | 2019-11-25 | Composite heart or blood vessel patch |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112089893A (en) * | 2020-08-07 | 2020-12-18 | 浙江理工大学 | Preparation method of high-breathability elastic nanofiber heart patch with controllable conductivity and viscosity |
| CN113907915A (en) * | 2021-09-27 | 2022-01-11 | 浙江大学 | Suture-free blood coagulation auxiliary fixing heart patch and preparation method thereof |
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| CN101007186A (en) * | 2006-12-30 | 2007-08-01 | 武汉科技学院 | A fabric enhanced composite vascular prosthesis |
| CN102068323A (en) * | 2011-01-21 | 2011-05-25 | 南京师范大学 | Cardiac or vascular patch with anticoagulant effect |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112089893A (en) * | 2020-08-07 | 2020-12-18 | 浙江理工大学 | Preparation method of high-breathability elastic nanofiber heart patch with controllable conductivity and viscosity |
| CN113907915A (en) * | 2021-09-27 | 2022-01-11 | 浙江大学 | Suture-free blood coagulation auxiliary fixing heart patch and preparation method thereof |
| CN113907915B (en) * | 2021-09-27 | 2022-07-29 | 浙江大学 | Suture-free blood coagulation auxiliary fixing heart patch and preparation method thereof |
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