CN1107624C

CN1107624C - Package

Info

Publication number: CN1107624C
Application number: CN99801141A
Authority: CN
Inventors: 马丁·蒙蒂格尔·布朗内
Original assignee: Nycomed Imaging AS
Current assignee: Ge Health Care Ltd
Priority date: 1998-07-14
Filing date: 1999-07-14
Publication date: 2003-05-07
Anticipated expiration: 2019-07-14
Also published as: DK1044135T3; DE69903401T2; GB9815291D0; NO20001221L; ES2187172T3; CA2303213A1; ATE225735T1; JP4754070B2; ZA200001064B; DE69903401D1; KR20010052067A; AU742134B2; CN1309613A; AU4921599A; KR100385760B1; RU2184059C2; CA2303213C; NO319537B1; JP2003516277A; NO20001221D0

Abstract

A package (10) comprises a plastic bottle (20), a stopper (40) removably inserted into the mouth of the bottle, and a plastic cap (50). The cap has a cover member (52) which overlies the stopper and has a region (66) which is removable to expose the upper surface of the stopper to allow piercing thereof by a needle or the like. The removable region is provided with a pull-ring (68) protected from accidental operation by an annular wall (60) projecting upwardly from the edge of the cover member (52).

Description

Package

The present invention relates to a kind of package, in particular to a kind of package that is used for sterile fluid.

At medical field, sterile fluid for example medicine, medicine, aseptic saline solns or the like is often used in the treatment patient.These saliferous fluids are installed in the glass bottle usually, and the chemical property of glass is inertia and unlikely pollutes the saliferous fluid or be incorporated in the saliferous fluid.

The bottle stopper that glass bottle is inserted in the bottleneck usually seals.Bottle stopper is designed to be pierced through by the syringe needle of hypodermic syringe needle, infusion set or analogue, the content in the bottle can be taken out.

For with the bottle stopper fix in position, can bend and cover the top of bottle stopper and bottle to the bottle cap of making by aluminium or similar sheet metal material.For the bottle stopper of can coming in and going out, perhaps it is pierced through, perhaps take off bottle stopper, and bottle cap or partly torn or all torn.

Although this package is widely used, still there are many shortcomings in it.For example, glass bottle may be heavier.In addition, glass is a kind of more frangible material, and glass bottle also is easy to damage.It is especially true when the volume of bottle surpasses 100ml.For reducing the accidental damage in the transportation, must carefully pack these glass bottles, be provided with simultaneously bottle insert spaced apart from each other.Because this insert has taken certain volume, therefore minimizing is contained in the quantity of bottle in the given space, thereby the cost of transporting glass bottle is increased.

In addition, aluminium lid is torn also and may have problems, because on the position that lid is torn, will form a sharp edges.These edges are very sharp, are enough to puncture the gloves of operation usefulness and the skin of human body, and clearly, for the medical field that must guarantee the possibility of infection minimum, this is a defective.

In addition, in many European countries, waste product processed fall before, at first must classification by kind.Installation crown cap and bottle closure of rubber just mean that also this package comprises three kinds of different classes of materials (glass, metal and plastics) on glass bottle, and these materials must separate processes.

Someone is attempting producing many containers that are used for sterile fluid, and has obtained success in various degree.In a kind of known product, adopted the plastic bottle that is provided with threaded cap, comprise a coupled bottle stopper on the threaded cap.When threaded cap was removed, bottle stopper also was removed from bottle.Even now can be avoided the problem of using glass bottle to produce, but this package can not be used for injection work, and can not resemble and use with hypodermic needle the Packaging Bottle of standard.

DE19500460 discloses another plastic bottle, and this plastic bottle is provided with an injection molded lid, covers and is covered with a plastic tab.In this application, bottle stopper is not set in the bottleneck, the sealing of bottle mainly depends on the integrally molded wall that seals, rather than other openable device, and the described wall that seals can be by a needle tubing or needle pierces.Described lid covering is sealed wall and is joined.When the content in the needs use bottle, thin slice will be removed, must pierce through simultaneously lid and seal wall, this needs enough power to penetrate these parts, the possibility that wall material blocks is sealed in needle tubing or syringe needle existence simultaneously, perhaps because needle tubing or syringe needle form particle to the getting core of material in the content in bottle.

The plastic bottle that use has traditional stopper is known, and wherein bottle stopper is fixed by aluminium lid.This plastic bottle also existed before throwing away as waste product classifies each parts of package and when aluminium lid is torn, will stay the problem of a sharp edges.

Sealing of other type of being made by the Stelim of France now just sold on market with the name of " Monobloc " and " Duobloc "." Monobloc " seals and comprises that one is assemblied in the bottleneck of traditional glass bottle and the vinyl cover on the bottle stopper.One can contact bottle stopper by the part that dotted line is torn, and whole bottle cap can be taken off if desired." Duobloc " seals and seals similarly with " Monobloc ", but is provided with a threaded insert, and this insert is stuck in by hasp on the bottleneck of glass bottle, and the remainder of bottle cap meshes by screw thread and this insert.But these two kinds of glass bottles all have problems, and before package was processed, the various piece of package must be classified.

One aspect of the present invention is to provide a kind of package, comprise that one is provided with the container of mouth, one removably is inserted into stopper and the lid that covers described stopper in the described mouth, wherein, described lid comprises that but can be removed attachment of partial sum, the described part of removing can be removed to contact described lid, but described attachment are used for removing the described part of removing by user's operation, it is characterized in that, but a wall extends along the periphery of described attachment generally, to prevent its involuntary maneuver or tied up in knots, its feature is that also described wall comprises at least one through hole.

By the container and the lid of package made of plastic, weight and the damageable problem that can avoid glass container to have.In addition, before throwing away package, do not need the container and the cover of package are categorized into glass, metal and plastics yet.

Stopper is generally made by elastomeric material, and preferably also is made of plastics.Stopper also can be made by rubber.

In a preferred embodiment, container is a bottle.When sterile fluid was loaded in the glass bottle routinely, this scheme was best, even and package be made from a variety of materials, also preferably can avoid obscuring by the material of packing into identical form in end user part.

Container and lid preferably include the screw thread of working in coordination.So just provide lid has been fixed to a kind of simple but effective method on the container.

Lid preferably includes the indicating device of uncapping, with reduce fluid from opened and again the osed top package for the possibility of medicine.This opening with closing again may make fluid not have aseptic, or makes fluid mix impurity or contaminated with certain form.A kind of suitable form of indicating device of uncapping is one and is detachably attached to the parts that cover, before Jiang Gai takes off, must earlier these parts be disassembled from covering.Like this, if these parts do not exist, so just show that this package is opened in certain time, can not re-use.

In a preferred embodiment, lid comprises a removable part, and this part can be removed can contact stopper.

Comprise that sealing of this lid can be opened in many ways.Removable part can be dismantled, and with the contact stopper, stopper is remained on its original position.Then, stopper can be pierced through by hypodermic needle or analogue.Perhaps, whole lid can be taken off (can simultaneously the indicating device of uncapping be taken off), so just can contact whole stopper.If used infusion niidl is wider than removable part, this point just is very useful so.Select as another kind, whole lid and stopper can be taken off, packing into or to insert tubule or sleeve pipe, thereby charge into medicine for automatic injector.

Described lid preferably includes pieceable parts, and the user can utilize these parts that removable part is removed.So just be easy to remove the dismounting of part.

In a preferred embodiment, but attachment comprise one in the upward direction with can remove the ring that separates of part.But this set can make the user of package use finger hook under attachment, so just is easier to operation.

In another preferred embodiment, but described lid comprises that at least one is used as the projection of the pivot of attachment.If do not adopt pivot, but the power that acts on the attachment of user is just simply passed to removable section so.But if be provided with pivot point, but leverage can make the power that acts on the following attachment amplify so, thereby is easier to remove detachable portion.

In a preferred embodiment, but attachment are outstanding from covering, thereby so just make these parts have the possibility that is wrapped on some parts and is removed detachable portion by maloperation.Therefore, but described lid preferably also is provided with a wall that extends generally along the periphery of attachment, with prevent its maloperation or with other package tied up in knots.Thereby but attachment " are shrouded ", and reduced the possibility of this parts involuntary maneuver.If pieceable parts are draw ring, so this draw ring can be protected along its whole periphery.

Preferably also be provided with at least one through hole on the described wall.Most of medicinal sterile fluid package is all sterilized by autoclaving under steam pressure, so steam may condense into water on package under the environment of high voltage sterilizing device cooling.If described wall does not damage, this wall will form a cup that catchments so.The opening that is arranged on the wall allows water is discharged.

Described lid preferably is provided with one and is closed in case the parts that the localized area of detent plug engages with stopper when being subjected to polluting when package.These parts are an annular element that extends and engage with the upper surface of stopper downwards from described lid preferably.Like this, this annular element has just formed physical barriers to pollution, and helps to keep the aseptic of localized area.The sealing member of the one that is formed by these parts is preferably formed by the parts of the part elastic deformation that it is engaged with stopper.

But a wall is set is considered to an independently inventive features with the design that prevents the attachment involuntary maneuver, therefore a kind of package is provided according to a second aspect of the invention, this package comprises: one is provided with the container of mouth, one detachably is inserted into stopper and the lid that covers described stopper in the described mouth, it is characterized in that: described lid comprises a detachable portion, this part can be removed, to contact described stopper; One pieceable parts, these parts can be by user's operation to remove detachable portion; But the wall that the periphery of edge attachment extends is to prevent involuntary maneuver or tied up in knots.

For above-mentioned purpose, preferably be provided with at least one through hole on the described wall.

In another preferred embodiment, described mouth has an internal diameter, and described container is in the zone that comprises footpath within an internal diameter is less than described mouth under the described mouth.When by hypodermic syringe needle or analogue during to power of stopper effect, the necking down of Xing Chenging helps preventing that stopper is pushed in the container like this.When stopper was pushed down, it was resisted against bottleneck, so just can prevent that it from further moving down.

The design that forms this constriction is an independently inventive features, so a third aspect of the present invention is: a kind of package is provided, and this package comprises that one is provided with the container of mouth, and described mouth is used to hold stopper, and has an internal diameter; Described container be provided with under the described mouth internal diameter less than described mouth within the footpath the zone, thereby prevent that described stopper from moving in the described zone from described mouth.

With reference to accompanying drawing, by embodiment the preferred embodiments of the present invention are made an explanation, wherein accompanying drawing:

Fig. 1 is the partial cross sectional side elevation view of the package of first embodiment of the invention;

Fig. 2 is the cutaway view of stopper;

Fig. 3 is the cutaway view along Fig. 1 hatching III-III;

Fig. 4 is the cutaway view along Fig. 1 hatching IV-IV;

Fig. 5 is used for the lateral plan of the lid of package for second embodiment of the invention;

Fig. 6 is the plan view of lid shown in Figure 5;

Fig. 7 is the cutaway view along Fig. 6 hatching VII-VII;

Fig. 8 is the lateral plan of another kind of lid;

Fig. 9 is the cutaway view of another kind of bottle;

Figure 10 is the partial enlarged view of Fig. 9.

Fig. 1 shows the package 10 of first embodiment of the invention.Package 10 comprises a plastic bottle 20, one bottle stoppers 40 and plastic closures lid 50.Bottle stopper is preferably made by thermoplastic, polymeric materials, but also can be made by other synthesizing polymeric material or neoprene (for example neoprene based rubber) or natural rubber.

Bottle 20 comprises the neck that narrows down 26 that a bottle 22, one shoulder parts 24 and are partly stretched out from shoulder.The outside face of neck is provided with outside thread 28.One flange 30 radially outward protrudes from neck 26 under outside thread 28.

The inside face of neck is cylindrical shape substantially.But this inside face also comprises the part 32 that a diameter reduces.The purpose that this part is set is: when masterpiece is used on the bottle stopper, when for example syringe needle of using by hypodermic injection or analogue are used for masterpiece on the bottle stopper, prevent that bottle stopper 40 is pushed in the bottleneck 26.The diameter of this part is slightly less than the diameter of bottleneck remainder, as shown in Figure 1; The diameter of the also comparable bottleneck remainder of the diameter of this part is little a lot, as shown in Figures 9 and 10.

Bottle stopper 40 comprises that one is roughly columnar main body 42, and the radius of this main body 42 is slightly larger than the radius of bottleneck inside face.The base portion 42 that so just can make bottle stopper 40 with interference fit in bottleneck 26.Thereby make bottle stopper sealing bottle.The lower end of main body 42 comprises a chamfering 44, is beneficial to main body 42 is inserted in the neck 26 of bottle 20.

One flange 46 is set in the upper end of main body 42.When bottle stopper 40 was inserted in the bottle fully, flange 46 was resisted against the top of bottleneck.

In addition, be provided with the part 48 of a hollow in the lower surface of bottle stopper 40.Hollow space 48 upwards extends towards the top of bottle stopper main body 42 from lower surface, thereby makes the length of the thickness at bottle stopper main body 42 middle parts much smaller than bottle stopper.The syringe needle or the analogue of the easier syringe needle of being used by hypodermic injection of bottle stopper, transfusion usefulness are pierced through.

Seal closure 50 is connected to the top of bottleneck 26.This lid comprises that one covers the protective cover means 52 on the bottle stopper 40 and the skirtboard 54 of an annular, and skirtboard 54 extends downwards from the edge of protective cover means 52.

Skirtboard 54 comprises that one is formed at the negative thread 56 on its inside face, and this negative thread 56 is meshed with outside thread 28 on being formed at bottleneck 26, will seal fix in position.

A ring 57 is detachably connected on skirtboard 54 lower ends.Ring 57 is engaged in the flange 30 times on the bottleneck 26.Like this, this detouchable ring 57 is just as uncapping indicating device.Take off from bottle 20 for covering 50, at first need ring 57 is disassembled from bottle cap 50, the ring 57 that is removed can make the user clear: package 10 has been opened.

The downside of protective cover means 52 is provided with an annular element 58, and this parts 58 extend downwards from protective cover means.The lower end of annular element engages with the upper surface of bottle stopper 40, and helps guaranteeing the integraty of package.In addition, annular element 58 surrounds the middle section of bottle stopper upper surface, and this helps preventing that it from being polluted.Because the middle section of bottle stopper upper surface is when bottle stopper is pierced, the part of syringe needle or analogue contact, so being provided with of annular element 58 is beneficial to the aseptic that guarantees whole package.

One be on the whole the annular wall 60 protruding upward from the edge of protective cover means 52, the girth of wall 60 is identical with the girth of protective cover means 52.Annular wall 60 is provided with a plurality of openings 62 (being four openings) in illustrated embodiment, thereby can think four arcwalls that separate.The purpose that opening 62 is set is: all fluids on protective cover means 52 tops are drained.The package of sterile fluid is often by autoclave sterilization, and is aseptic to guarantee it, and the steam in the autoclave might condense on the package at cooling stage very much.If annular wall 60 is not provided with opening 62, annular wall 60 will form the cup of a preservation condensed water so.Like this, just need reverse package spare, perhaps remove condensed water by evaporation to remove condensed water.Because annular wall 60 is provided with opening 62, therefore can simply water be discharged.Can be by forming the discharge that parts 52 impel water as follows: parts 52 be plane, for example can make these parts be provided with one and be higher than the middle body that protrude the neighboring area.

The upper surface of protecting cover 52 is provided with a low-intensity line 64 around zone 66.The low-intensity line helps removing zone 66.Remove the upper surface that zone 66 will expose bottle stopper 40, then its upper surface can be pierced through with syringe needle or analogue by hypodermic injection.

Be connected on the zone 66 by two footing 70 for removing zone 66, one draw rings 68, footing 70 extends to a side of draw ring 68 from the zone 66 of the protecting cover 52 that defined by low-intensity line 64.Footing, draw ring and annular wall are aligned to the form under the top surface that the upper surface that makes draw ring 68 is positioned at annular wall 60.So just can play the effect of protection draw ring 68, thereby prevent its involuntary maneuver and prevent that its damage from sealing.

The upper surface of protective cover means 52 also is provided with two upright parts 72,74, these two parts are arranged at the relative both sides of draw ring along diametric(al), one of them (72) contiguous footing 70 is connected to the position on the draw ring 68, and another (74) are then relative with these parts (72).Upright parts 72,74 are selected size as follows: its top is positioned under the draw ring 68 just.Upright parts 74 make draw ring part 68 relative protective cover means 52 distance that makes progress be arranged from footing, thereby when needs are mentioned draw ring, are easy to contact draw ring.Draw ring 68 and projection 74 are made into integration and the bridging by a frangibility is connected together.Connection between draw ring and the projection means encircling pull-up with before opening container, must apply an extra power, so that draw ring separates with projection, this extra power has reduced the possibility of unexpected unlatching.But this connection can be saved in other embodiments.

Be connected to locational vertical part 72 on the draw ring 68 as the pivot of draw ring 68, be beneficial to remove zone 66 near footing 70.When being pulled up, shown in the arrow among Fig. 4 76, the lower surface of draw ring 68 contacts and rotates about it with the upper surface of vertical part 72 when the free side of draw ring (promptly apart from the footing place of being connected farthest that side).Because the point of draw ring 68 on its edge rotates, therefore whole draw ring 68 can be mentioned by user's applied force, when especially the part that is connected with draw ring when footing 70 moves apart protective cover means 52.Footing just hauls the zone 66 of the protective cover means 52 that is centered on by low-intensity line 64 like this, and may make it break away from the remainder of seal closure 50.In addition, the lever that is formed by the use of pivot has increased footing 70 and has acted on power on the protective cover means 52, and helps removing the zone 66 of protective cover means more.

When the zone 66 of protecting cover 52 parts is removed, will on protecting cover, stays next opening, thereby expose bottle stopper 40.The edge that the edge of this opening and quilt are torn part all is made of plastics, and can not show a candle to the sharp edges that is formed by the metal that tears.Therefore, can obviously reduce the user and cause possibility of infection by the edge scuffing and by scuffing.

Package 10 can be opened by diverse ways.Draw ring 68 can be by mentioning and spurring the zone 66 that draw ring 68 is used to remove the protective cover means 52 of being surrounded by low-intensity line 64 at first, as mentioned above.The surface portion that has so just exposed bottle stopper 40, this surface portion can be pierced through with syringe needle or analogue with syringe needle or transfusion by hypodermic injection, with the content of contact packing part 10.In case enough contents are taken out, and so whole package (comprise bottle 20, bottle stopper 40 and cover 50 remainder) all will be thrown away.Because whole package all is made of plastics, therefore needn't or be used for waste disposal and various piece is classified for repeated usage.

The second, lid 50 can be removed itself, then removes bottle stopper 40.This disassembles detachable ring 56 with regard to requiring from the bottom of covering 50 skirtboard 54, then back out lid and lid is thrown away.Bottle stopper can be removed, and the content in the bottle is poured out, and perhaps inserts the thin bar of a tubule or automatic injector.In case the content in the package 10 is removed, so just can directly throw away package without classification.

Because the container of package 10 and lid part are made of plastics fully, therefore compare with existing package, package of the present invention has lot of advantages.For example, compare with glass bottle, plastic bottle is lighter, and is not easy to damage.Thereby when transport package, can take less preventive, use less auxiliary package material, and need less space for the package of giving determined number.In addition, before the pack processing piece installing, needn't partly classify to the container and the lid of package.Torn the possibility that part is hurted sb.'s feelings but also can reduce lid, because the part of tearing is plastics rather than metal.

The lid that is used for second embodiment of the invention as shown in Figs. 5 to 7.This lid is similar to the lid of first embodiment that is used for package, and identical feature is represented by identical Reference numeral.

Identical with first embodiment, lid comprises that one is connected to the draw ring on the dismountable zone.But different with first embodiment, the draw ring in the present embodiment only is connected by a footing 78.In addition, upright parts 72,74 have been saved.Because vertical part 72 is not set, therefore removable zone must not use aforesaid leverage to be removed.But, vertical part 74 is not set can makes the user be easier under draw ring, hook finger, because needn't avoid upright parts or draw ring is broken from vertical part.

In addition, the form that low-intensity line 64 can groove is formed at protective cover means 52 downsides of lid, rather than resembles and be arranged on the upper surface of protective cover means 52 first embodiment.So just improved the outward appearance of lid, but also can be used for improving the aseptic of whole package, because this embodiment has eliminated the possibility of accumulation of impurities in supine groove.It should further be appreciated that: the protective cover means of lid is higher than its periphery and is formed with its middle section, is beneficial to draining.As shown in Figure 7.

Another kind of lid as shown in Figure 8.This lid is provided with snap fit 80, so that it is connected with syringe.

Claims

1. a package (10), comprise that one is provided with the container (20) of mouth, one removably is inserted into stopper (40) and the lid (50) that covers described stopper in the described mouth, wherein, described lid comprise one can remove the part (66) but and attachment (68), the described part of removing can be removed to contact described lid, but described attachment are used for removing the described part of removing by user's operation, it is characterized in that, a wall (60) but extend along the periphery of described attachment generally, to prevent its involuntary maneuver or tied up in knots, its feature is that also described wall comprises at least one through hole (62).

2. package as claimed in claim 1 (10) is characterized in that, described container (20) and described lid (50) are made of plastics.

3. package as claimed in claim 2 (10) is characterized in that, but described attachment (68) comprise that one upwards removes the ring that part (66) separates with described.

4. package as claimed in claim 3 (10) is characterized in that, described lid (50) comprises at least one projection (72), but described projection is as the pivot of described attachment (68).

5. package as claimed in claim 4 (10) is characterized in that, described lid (50) is provided with parts that engage with described stopper (58) when described package is closed, polluted with the localized area that prevents described bottle stopper.

6. package as claimed in claim 5 (10) is characterized in that described mouth has an internal diameter, and described container (20) is provided with a zone (32) under described mouth, and this regional internal diameter is less than the internal diameter of described mouth.

7. package as claimed in claim 1 (10) is characterized in that, but described attachment (68) comprise that one upwards removes the ring that part (66) separates with described.

8. package as claimed in claim 7 (10) is characterized in that, described lid (50) comprises at least one projection (72), but described projection is as the pivot of described attachment (68).

9. package as claimed in claim 8 (10) is characterized in that, described lid (50) is provided with parts that engage with described stopper (58) when described package is closed, polluted with the localized area that prevents described bottle stopper.

10. package as claimed in claim 9 (10) is characterized in that described mouth has an internal diameter, and described container (20) is provided with a zone (32) under described mouth, and this regional internal diameter is less than the internal diameter of described mouth.

11. package as claimed in claim 1 (10) is characterized in that, described lid (50) comprises at least one projection (72), but described projection is as the pivot of described attachment (68).

12. package as claimed in claim 11 (10) is characterized in that, described lid (50) is provided with parts that engage with described stopper (58) when described package is closed, polluted with the localized area that prevents described bottle stopper.

13. package as claimed in claim 12 (10) is characterized in that described mouth has an internal diameter, described container (20) is provided with a zone (32) under described mouth, and this regional internal diameter is less than the internal diameter of described mouth.

14. package as claimed in claim 1 (10) is characterized in that, described lid (50) is provided with parts that engage with described stopper (58) when described package is closed, polluted with the localized area that prevents described bottle stopper.

15. package as claimed in claim 14 (10) is characterized in that described mouth has an internal diameter, described container (20) is provided with a zone (32) under described mouth, and this regional internal diameter is less than the internal diameter of described mouth.

16. package as claimed in claim 1 (10) is characterized in that described mouth has an internal diameter, described container (20) is provided with a zone (32) under described mouth, and this regional internal diameter is less than the internal diameter of described mouth.

17. the described package of one of claim (10) is characterized in that as described above, described lid (50) is provided with the indicating device (57) of uncapping, and is connected on the described lid this part detachable.

18. package as claimed in claim 17 (10) is characterized in that, the described indicating device of uncapping (57) is a ring under the flange (30) that is engaged in container (20).