CN110755364A - Compound benzoic acid ointment - Google Patents
Compound benzoic acid ointment Download PDFInfo
- Publication number
- CN110755364A CN110755364A CN201810818326.3A CN201810818326A CN110755364A CN 110755364 A CN110755364 A CN 110755364A CN 201810818326 A CN201810818326 A CN 201810818326A CN 110755364 A CN110755364 A CN 110755364A
- Authority
- CN
- China
- Prior art keywords
- benzoic acid
- glass container
- percent
- ethylparaben
- camphor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 title claims abstract description 64
- 239000005711 Benzoic acid Substances 0.000 title claims abstract description 32
- 235000010233 benzoic acid Nutrition 0.000 title claims abstract description 32
- 150000001875 compounds Chemical class 0.000 title claims abstract description 13
- 239000002674 ointment Substances 0.000 title claims abstract description 13
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000011521 glass Substances 0.000 claims abstract description 30
- 239000000843 powder Substances 0.000 claims abstract description 29
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 19
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 12
- 241000723346 Cinnamomum camphora Species 0.000 claims abstract description 12
- 229960000846 camphor Drugs 0.000 claims abstract description 12
- 229930008380 camphor Natural products 0.000 claims abstract description 12
- 239000004359 castor oil Substances 0.000 claims abstract description 12
- 235000019438 castor oil Nutrition 0.000 claims abstract description 12
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims abstract description 12
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims abstract description 12
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims abstract description 12
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims abstract description 12
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 12
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims abstract description 12
- 238000003756 stirring Methods 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 9
- 238000010438 heat treatment Methods 0.000 claims abstract description 9
- 239000000463 material Substances 0.000 claims abstract description 9
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 9
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000008117 stearic acid Substances 0.000 claims abstract description 9
- 239000003871 white petrolatum Substances 0.000 claims abstract description 9
- 238000001816 cooling Methods 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 abstract description 8
- 238000002360 preparation method Methods 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 description 10
- 238000000227 grinding Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 230000002147 killing effect Effects 0.000 description 3
- 229920000832 Cutin Polymers 0.000 description 2
- 201000010618 Tinea cruris Diseases 0.000 description 2
- 206010067197 Tinea manuum Diseases 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 201000004647 tinea pedis Diseases 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229940124091 Keratolytic Drugs 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- CUBCNYWQJHBXIY-UHFFFAOYSA-N benzoic acid;2-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1O CUBCNYWQJHBXIY-UHFFFAOYSA-N 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000001530 keratinolytic effect Effects 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a compound benzoic acid ointment and a preparation method thereof, the product belongs to the field of pharmacy, and the raw materials used for producing the product comprise the following components in parts by weight: 13 to 15 percent of benzoic acid powder, 7 to 9 percent of salicylic acid powder, 62 percent of white vaseline, 10 percent of stearic acid, 4 percent of castor oil, 1 percent of camphor, 0.9 percent of sodium dodecyl benzene sulfonate and 0.1 percent of ethylparaben, and the process is as follows: mixing white vaseline and stearic acid according to the formula ratio, feeding into a first glass container, heating to 72-78 ℃ by using a water bath, adding benzoic acid powder and salicylic acid powder according to the formula ratio after the first glass container is completely melted, and uniformly stirring; feeding the castor oil, the camphor, the sodium dodecyl benzene sulfonate and the ethylparaben with the formula ratio into a second glass container, and heating in a water bath to 82-88 ℃ until the castor oil, the camphor, the sodium dodecyl benzene sulfonate and the ethylparaben are completely dissolved; and pouring all the materials in the second glass container into the first glass container, uniformly stirring, and cooling to normal temperature to obtain a finished product.
Description
The technical field is as follows:
the invention belongs to the field of pharmacy, and particularly relates to a compound benzoic acid ointment and a preparation method thereof.
Background art:
the compound benzoic acid ointment is a dermatologic externally-applied medicine, has the effects of softening cutin and killing mold, and is mainly used for treating chronic tinea manuum, tinea pedis, tinea cruris and the like. The main components of the product are benzoic acid and salicylic acid, the pharmacological action of the benzoic acid is a disinfection preservative, and the product has a killing effect on common bacteria and fungi; the salicylic acid has pharmacological action of keratolytic softening agent, and has antibacterial and antipruritic effects. The traditional production method comprises the following steps: the preparation method comprises the following steps of taking salicylic acid and benzoic acid powder, adding a little liquid paraffin, grinding, gradually adding lanolin and vaseline, and grinding uniformly to obtain the composition, wherein the method has the biggest defects that: the salicylic acid and benzoic acid crystals have strong pungent smell in the process of being ground, have great harm to human bodies and cause severe operating environment. The invention adopts a new process, avoids the production process that salicylic acid and benzoic acid crystals have strong pungent smell and great harm to human bodies in the process of grinding, so that the operation environment is relatively severe, and simultaneously adds a plurality of new ingredients, so that the use effect of the compound benzoic acid ointment is improved, and the invention has the main advantages that: compared with the product produced by the traditional production method, the product has improved use effect, eliminates the grinding process of salicylic acid and benzoic acid powder, and can effectively protect the health of operators.
The invention content is as follows:
the invention provides a compound benzoic acid ointment and a preparation method thereof, and raw materials used for producing the product comprise the following components in parts by weight: 13-15% of benzoic acid powder, 7-9% of salicylic acid powder, 62% of white vaseline, 10% of stearic acid, 4% of castor oil, 1% of camphor, 0.9% of sodium dodecyl benzene sulfonate and 0.1% of ethylparaben.
The technical scheme adopted by the invention is as follows:
(1) mixing white vaseline and stearic acid according to the formula ratio, feeding into a first glass container, heating to 72-78 ℃ by using a water bath, adding benzoic acid powder and salicylic acid powder according to the formula ratio after the first glass container is completely melted, and uniformly stirring;
(2) feeding the castor oil, the camphor, the sodium dodecyl benzene sulfonate and the ethylparaben with the formula ratio into a second glass container, and heating in a water bath to 82-88 ℃ until the castor oil, the camphor, the sodium dodecyl benzene sulfonate and the ethylparaben are completely dissolved;
(3) and pouring all the materials in the second glass container into the first glass container, uniformly stirring, and cooling to normal temperature to obtain a finished product.
Preferably, the purity of the benzoic acid powder is 99%.
Preferably, the purity of the salicylic acid fine powder is 98%.
Preferably, the granularity of the fine benzoic acid powder and the fine salicylic acid powder is below 200 meshes.
Preferably, the normal temperature is 3-35 ℃.
The product of the invention has the beneficial effects that: the production process of the method omits the grinding process of salicylic acid and benzoic acid powder, the health of operators can be effectively protected, the production process is pollution-free, the compound benzoic acid ointment has fine particles, has the effects of softening cutin and killing mold, and is mainly used for treating chronic tinea manuum, tinea pedis, tinea cruris and the like.
The specific implementation mode is as follows:
example 1:
mixing 62% of white vaseline and 10% of stearic acid, feeding the mixture into a first glass container, heating the mixture to 72 ℃ by using a water bath, adding 13% of benzoic acid powder and 9% of salicylic acid powder after the mixture is completely melted in the first glass container, and uniformly stirring; 4 percent of castor oil, 1 percent of camphor, 0.9 percent of sodium dodecyl benzene sulfonate and 0.1 percent of ethylparaben in the total amount are sent into a second glass container and heated to 82 ℃ in water bath until the materials are completely dissolved; and pouring all the materials in the second glass container into the first glass container, uniformly stirring, and cooling to normal temperature to obtain a finished product.
Example 2:
mixing 62% of white vaseline and 10% of stearic acid, feeding the mixture into a first glass container, heating the mixture to 75 ℃ by using a water bath, adding 14% of benzoic acid powder and 8% of salicylic acid powder after the mixture is completely melted in the first glass container, and uniformly stirring; 4 percent of castor oil, 1 percent of camphor, 0.9 percent of sodium dodecyl benzene sulfonate and 0.1 percent of ethylparaben in the total amount are put into a second glass container and heated to 85 ℃ in water bath until the materials are completely dissolved; and pouring all the materials in the second glass container into the first glass container, uniformly stirring, and cooling to normal temperature to obtain a finished product.
Example 3:
mixing 62% of white vaseline and 10% of stearic acid, feeding the mixture into a first glass container, heating the mixture to 78 ℃ by using a water bath, adding 15% of benzoic acid powder and 7% of salicylic acid powder after the mixture is completely melted in the first glass container, and uniformly stirring; 4 percent of castor oil, 1 percent of camphor, 0.9 percent of sodium dodecyl benzene sulfonate and 0.1 percent of ethylparaben in the total amount are sent into a second glass container and heated to 88 ℃ in water bath until the materials are completely dissolved; and pouring all the materials in the second glass container into the first glass container, uniformly stirring, and cooling to normal temperature to obtain a finished product.
Claims (5)
1. The compound benzoic acid ointment comprises the following raw materials in parts by weight: 13-15% of benzoic acid powder, 7-9% of salicylic acid powder, 62% of white vaseline, 10% of stearic acid, 4% of castor oil, 1% of camphor, 0.9% of sodium dodecyl benzene sulfonate and 0.1% of ethylparaben, and is characterized in that:
(1) mixing white vaseline and stearic acid according to the formula ratio, feeding into a first glass container, heating to 72-78 ℃ by using a water bath, adding benzoic acid powder and salicylic acid powder according to the formula ratio after the first glass container is completely melted, and uniformly stirring;
(2) feeding the castor oil, the camphor, the sodium dodecyl benzene sulfonate and the ethylparaben with the formula ratio into a second glass container, and heating in a water bath to 82-88 ℃ until the castor oil, the camphor, the sodium dodecyl benzene sulfonate and the ethylparaben are completely dissolved;
(3) and pouring all the materials in the second glass container into the first glass container, uniformly stirring, and cooling to normal temperature to obtain a finished product.
2. The compound benzoic acid ointment according to claim 1, which is characterized in that: the purity of the benzoic acid powder is 99%.
3. The compound benzoic acid ointment according to claim 1, which is characterized in that: the purity of the salicylic acid fine powder is 98%.
4. The compound benzoic acid ointment according to claim 1, which is characterized in that: the granularity of the benzoic acid powder and the salicylic acid fine powder is below 200 meshes.
5. The compound benzoic acid ointment according to claim 1, which is characterized in that: the normal temperature is 3-35 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810818326.3A CN110755364A (en) | 2018-07-24 | 2018-07-24 | Compound benzoic acid ointment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810818326.3A CN110755364A (en) | 2018-07-24 | 2018-07-24 | Compound benzoic acid ointment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110755364A true CN110755364A (en) | 2020-02-07 |
Family
ID=69326822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810818326.3A Withdrawn CN110755364A (en) | 2018-07-24 | 2018-07-24 | Compound benzoic acid ointment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110755364A (en) |
-
2018
- 2018-07-24 CN CN201810818326.3A patent/CN110755364A/en not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20200207 |
|
| WW01 | Invention patent application withdrawn after publication |