CN110734376A - Preparation method of 2-methyl-4-acetoxyl-2-butenal - Google Patents
Preparation method of 2-methyl-4-acetoxyl-2-butenal Download PDFInfo
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- CN110734376A CN110734376A CN201810802768.9A CN201810802768A CN110734376A CN 110734376 A CN110734376 A CN 110734376A CN 201810802768 A CN201810802768 A CN 201810802768A CN 110734376 A CN110734376 A CN 110734376A
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- LPDDKAJRWGPGSI-UHFFFAOYSA-N (3-methyl-4-oxobut-2-enyl) acetate Chemical compound CC(=O)OCC=C(C)C=O LPDDKAJRWGPGSI-UHFFFAOYSA-N 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 24
- 238000003786 synthesis reaction Methods 0.000 claims abstract description 24
- 238000006317 isomerization reaction Methods 0.000 claims abstract description 18
- 238000007037 hydroformylation reaction Methods 0.000 claims abstract description 17
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 13
- 230000021736 acetylation Effects 0.000 claims abstract description 10
- 238000006640 acetylation reaction Methods 0.000 claims abstract description 10
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 69
- 150000001875 compounds Chemical class 0.000 claims description 65
- 239000003054 catalyst Substances 0.000 claims description 49
- 238000006243 chemical reaction Methods 0.000 claims description 41
- 239000007789 gas Substances 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 29
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 28
- 239000002904 solvent Substances 0.000 claims description 25
- 229910052739 hydrogen Inorganic materials 0.000 claims description 17
- 239000001257 hydrogen Substances 0.000 claims description 15
- 229910052703 rhodium Inorganic materials 0.000 claims description 14
- 239000010948 rhodium Substances 0.000 claims description 14
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 12
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims description 12
- 239000012345 acetylating agent Substances 0.000 claims description 11
- -1 dicarbonyl (acetylacetone) rhodium Chemical compound 0.000 claims description 10
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 8
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 231100000572 poisoning Toxicity 0.000 claims description 7
- 230000000607 poisoning effect Effects 0.000 claims description 7
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 6
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 6
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims description 6
- 239000008096 xylene Substances 0.000 claims description 6
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 4
- MNOILHPDHOHILI-UHFFFAOYSA-N Tetramethylthiourea Chemical group CN(C)C(=S)N(C)C MNOILHPDHOHILI-UHFFFAOYSA-N 0.000 claims description 4
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- UKVIEHSSVKSQBA-UHFFFAOYSA-N methane;palladium Chemical group C.[Pd] UKVIEHSSVKSQBA-UHFFFAOYSA-N 0.000 claims description 4
- 239000003208 petroleum Substances 0.000 claims description 4
- 150000003568 thioethers Chemical class 0.000 claims description 4
- 150000003573 thiols Chemical group 0.000 claims description 4
- 150000003585 thioureas Chemical class 0.000 claims description 4
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 4
- LOXRGHGHQYWXJK-UHFFFAOYSA-N 1-octylsulfanyloctane Chemical compound CCCCCCCCSCCCCCCCC LOXRGHGHQYWXJK-UHFFFAOYSA-N 0.000 claims description 3
- AACIZACVKFEETJ-UHFFFAOYSA-N O=C=[RhH].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 Chemical compound O=C=[RhH].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 AACIZACVKFEETJ-UHFFFAOYSA-N 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 claims description 3
- 229940092714 benzenesulfonic acid Drugs 0.000 claims description 3
- WQAQPCDUOCURKW-UHFFFAOYSA-N butanethiol Chemical compound CCCCS WQAQPCDUOCURKW-UHFFFAOYSA-N 0.000 claims description 3
- 229910052763 palladium Inorganic materials 0.000 claims description 3
- QBERHIJABFXGRZ-UHFFFAOYSA-M rhodium;triphenylphosphane;chloride Chemical compound [Cl-].[Rh].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 QBERHIJABFXGRZ-UHFFFAOYSA-M 0.000 claims description 3
- HTIRHQRTDBPHNZ-UHFFFAOYSA-N Dibutyl sulfide Chemical compound CCCCSCCCC HTIRHQRTDBPHNZ-UHFFFAOYSA-N 0.000 claims description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 2
- GPMUMMNTAZMBEC-UHFFFAOYSA-N bis(oxomethylidene)rhodium Chemical compound [Rh].[O+]#[C-].[O+]#[C-] GPMUMMNTAZMBEC-UHFFFAOYSA-N 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims description 2
- 239000011261 inert gas Substances 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- KZCOBXFFBQJQHH-UHFFFAOYSA-N octane-1-thiol Chemical compound CCCCCCCCS KZCOBXFFBQJQHH-UHFFFAOYSA-N 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- TUQOTMZNTHZOKS-UHFFFAOYSA-N tributylphosphine Chemical compound CCCCP(CCCC)CCCC TUQOTMZNTHZOKS-UHFFFAOYSA-N 0.000 claims description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 1
- FFMRZGOBLFVKQY-UHFFFAOYSA-N 3-formylbut-3-enyl acetate Chemical compound CC(=O)OCCC(=C)C=O FFMRZGOBLFVKQY-UHFFFAOYSA-N 0.000 abstract description 25
- 239000002994 raw material Substances 0.000 abstract description 16
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 17
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 15
- 239000000047 product Substances 0.000 description 14
- 229910052757 nitrogen Inorganic materials 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- ULVSHNOGEVXRDR-UHFFFAOYSA-N 1,1-dimethoxypropan-2-one Chemical compound COC(OC)C(C)=O ULVSHNOGEVXRDR-UHFFFAOYSA-N 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 6
- 238000005886 esterification reaction Methods 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- 239000002351 wastewater Substances 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 238000004821 distillation Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000035484 reaction time Effects 0.000 description 5
- 229910001220 stainless steel Inorganic materials 0.000 description 5
- 239000010935 stainless steel Substances 0.000 description 5
- OYKWNTFKGZLZOJ-UHFFFAOYSA-N 2-ethyl-2-methyl-4,7-dihydro-1,3-dioxepine-5-carbaldehyde Chemical compound CC1(OCC=C(CO1)C=O)CC OYKWNTFKGZLZOJ-UHFFFAOYSA-N 0.000 description 4
- GUPGZURVZDIQPM-UHFFFAOYSA-N 2-oxoethyl acetate Chemical compound CC(=O)OCC=O GUPGZURVZDIQPM-UHFFFAOYSA-N 0.000 description 4
- HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 4
- NBBJYMSMWIIQGU-UHFFFAOYSA-N Propionic aldehyde Chemical compound CCC=O NBBJYMSMWIIQGU-UHFFFAOYSA-N 0.000 description 4
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 4
- 239000012295 chemical reaction liquid Substances 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 238000007086 side reaction Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- HXDLWJWIAHWIKI-UHFFFAOYSA-N 2-hydroxyethyl acetate Chemical compound CC(=O)OCCO HXDLWJWIAHWIKI-UHFFFAOYSA-N 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 238000009776 industrial production Methods 0.000 description 3
- 239000000543 intermediate Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- VSKQZDHNPXLOEU-UHFFFAOYSA-N (1,1-dimethoxy-2-methylbut-3-en-2-yl) acetate Chemical compound COC(OC)C(C)(C=C)OC(C)=O VSKQZDHNPXLOEU-UHFFFAOYSA-N 0.000 description 2
- URVYVINLDPIJEH-UHFFFAOYSA-N (4-chloro-3-methylbut-2-enyl) acetate Chemical compound CC(=O)OCC=C(C)CCl URVYVINLDPIJEH-UHFFFAOYSA-N 0.000 description 2
- LBRDQQPGFNRZGV-UHFFFAOYSA-N 1,1-dimethoxy-2-methylbut-3-en-2-ol Chemical compound COC(OC)C(C)(O)C=C LBRDQQPGFNRZGV-UHFFFAOYSA-N 0.000 description 2
- SIIGMSUCQCKUCY-UHFFFAOYSA-N 2-tert-butyl-2-methyl-4,7-dihydro-1,3-dioxepine-5-carbaldehyde Chemical compound CC1(OCC=C(CO1)C=O)C(C)(C)C SIIGMSUCQCKUCY-UHFFFAOYSA-N 0.000 description 2
- QZYCIZBUCPJIGT-UHFFFAOYSA-N 4-chloro-3-methylbut-2-en-1-ol Chemical compound ClCC(C)=CCO QZYCIZBUCPJIGT-UHFFFAOYSA-N 0.000 description 2
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 description 2
- 239000007818 Grignard reagent Substances 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 2
- JMJIHGHNBKYZAH-UHFFFAOYSA-N [3-(acetyloxymethyl)-4-oxobutyl] acetate Chemical compound CC(=O)OCCC(C=O)COC(C)=O JMJIHGHNBKYZAH-UHFFFAOYSA-N 0.000 description 2
- 238000005882 aldol condensation reaction Methods 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N butyric aldehyde Natural products CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 229910002091 carbon monoxide Inorganic materials 0.000 description 2
- 235000021466 carotenoid Nutrition 0.000 description 2
- 150000001747 carotenoids Chemical class 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 239000007806 chemical reaction intermediate Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 230000032050 esterification Effects 0.000 description 2
- 150000004795 grignard reagents Chemical class 0.000 description 2
- 238000005984 hydrogenation reaction Methods 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 229960000342 retinol acetate Drugs 0.000 description 2
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 2
- 235000019173 retinyl acetate Nutrition 0.000 description 2
- 239000011770 retinyl acetate Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- XBLBRVOSSJQTNS-UHFFFAOYSA-N (1-chloro-2-methylbut-3-en-2-yl) acetate Chemical compound CC(=O)OC(C)(CCl)C=C XBLBRVOSSJQTNS-UHFFFAOYSA-N 0.000 description 1
- PVVRUWASPMJSHJ-UHFFFAOYSA-N (2-methyl-1-oxobut-3-en-2-yl) acetate Chemical compound CC(=O)OC(C)(C=C)C=O PVVRUWASPMJSHJ-UHFFFAOYSA-N 0.000 description 1
- OHFDXHXDNYMPBW-UHFFFAOYSA-N (4,4-dimethoxy-3-methylbut-2-enyl) acetate Chemical compound COC(OC)C(C)=CCOC(C)=O OHFDXHXDNYMPBW-UHFFFAOYSA-N 0.000 description 1
- TVAATNSERHHVJT-UHFFFAOYSA-N (4-formyloxy-3-methylbut-2-enyl) acetate Chemical compound CC(=O)OCC=C(C)COC=O TVAATNSERHHVJT-UHFFFAOYSA-N 0.000 description 1
- WSBIBTVBOUYRGA-UHFFFAOYSA-N (4-hydroxy-3-methylbut-2-enyl) acetate Chemical compound CC(=O)OCC=C(C)CO WSBIBTVBOUYRGA-UHFFFAOYSA-N 0.000 description 1
- KZMCPAWWLSKKRI-UHFFFAOYSA-N 1,1-dimethoxy-2-methylbut-3-yn-2-ol Chemical compound COC(OC)C(C)(O)C#C KZMCPAWWLSKKRI-UHFFFAOYSA-N 0.000 description 1
- VUQIEMOGCCDRND-UHFFFAOYSA-N 1-chloro-2-methylbut-3-en-2-ol Chemical compound ClCC(O)(C)C=C VUQIEMOGCCDRND-UHFFFAOYSA-N 0.000 description 1
- WJDDIGRHHXHPBE-UHFFFAOYSA-N 1-oxobut-2-en-2-yl acetate Chemical compound C(C)(=O)OC(C=O)=CC WJDDIGRHHXHPBE-UHFFFAOYSA-N 0.000 description 1
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 1
- ZRCWIUTUYCOGJG-UHFFFAOYSA-N 2-ethyl-2-methyl-4,7-dihydro-1,3-dioxepine Chemical compound C(C)C1(OCC=CCO1)C ZRCWIUTUYCOGJG-UHFFFAOYSA-N 0.000 description 1
- HXONYKIVDNJZBB-UHFFFAOYSA-N 4-hydroxy-2-methylidenebutanal Chemical compound OCCC(=C)C=O HXONYKIVDNJZBB-UHFFFAOYSA-N 0.000 description 1
- VBCIOOKAKHGVMI-UHFFFAOYSA-N 5-methylhex-5-en-2-one Chemical compound CC(=C)CCC(C)=O VBCIOOKAKHGVMI-UHFFFAOYSA-N 0.000 description 1
- 229910021591 Copper(I) chloride Inorganic materials 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- VZUAUHWZIKOMFC-ONEGZZNKSA-N [(e)-4-acetyloxybut-2-enyl] acetate Chemical compound CC(=O)OC\C=C\COC(C)=O VZUAUHWZIKOMFC-ONEGZZNKSA-N 0.000 description 1
- 150000001241 acetals Chemical group 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000007259 addition reaction Methods 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- INLLPKCGLOXCIV-UHFFFAOYSA-N bromoethene Chemical compound BrC=C INLLPKCGLOXCIV-UHFFFAOYSA-N 0.000 description 1
- OZCRKDNRAAKDAN-UHFFFAOYSA-N but-1-ene-1,4-diol Chemical compound O[CH][CH]CCO OZCRKDNRAAKDAN-UHFFFAOYSA-N 0.000 description 1
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000007809 chemical reaction catalyst Substances 0.000 description 1
- 238000010668 complexation reaction Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 description 1
- 229940045803 cuprous chloride Drugs 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006356 dehydrogenation reaction Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 150000002148 esters Chemical group 0.000 description 1
- XZMMPTVWHALBLT-UHFFFAOYSA-N formaldehyde;rhodium;triphenylphosphane Chemical compound [Rh].O=C.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 XZMMPTVWHALBLT-UHFFFAOYSA-N 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- GDOPTJXRTPNYNR-UHFFFAOYSA-N methyl-cyclopentane Natural products CC1CCCC1 GDOPTJXRTPNYNR-UHFFFAOYSA-N 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- WFIZEGIEIOHZCP-UHFFFAOYSA-M potassium formate Chemical compound [K+].[O-]C=O WFIZEGIEIOHZCP-UHFFFAOYSA-M 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000006462 rearrangement reaction Methods 0.000 description 1
- 238000007142 ring opening reaction Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- IXZDIALLLMRYOU-UHFFFAOYSA-N tert-butyl hypochlorite Chemical compound CC(C)(C)OCl IXZDIALLLMRYOU-UHFFFAOYSA-N 0.000 description 1
- 150000003509 tertiary alcohols Chemical class 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/24—Preparation of carboxylic acid esters by reacting carboxylic acids or derivatives thereof with a carbon-to-oxygen ether bond, e.g. acetal, tetrahydrofuran
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
- C07C67/293—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
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- C07—ORGANIC CHEMISTRY
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- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/04—Seven-membered rings not condensed with other rings
- C07D321/06—1,3-Dioxepines; Hydrogenated 1,3-dioxepines
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Abstract
The invention provides a preparation method of 2-methyl-4-acetoxyl-2-butenal (I), which comprises the steps of preparing 2, 2-disubstituted-5-formyl-4, 7-dihydro-1, 3-dioxaheptin (III) by hydroformylation reaction by using 2, 2-disubstituted-4, 7-dihydro-1, 3-dioxaheptin (II) and synthesis gas as raw materials, reacting with an acetylation reagent to prepare 2-formyl-4-acetoxyl-1-butene (IV), and carrying out double bond isomerization to obtain the 2-methyl-4-acetoxyl-2-butenal (I).
Description
Technical Field
The invention relates to a preparation method of 2-methyl-4-acetoxyl-2-butenal, belonging to the technical field of medical chemistry.
Background
2-methyl-4-acetoxy-2-butenal (I) is a key intermediate for preparing vitamin A acetate and various carotenoids, and has the following structural formula:
the synthesis method of 2-methyl-4-acetoxyl-2-butenal is summarized as the following preparation method according to the difference of the main raw materials and the unit reaction:
1. 1, 1-dimethoxy acetone method
US4256878 and US5453547 take 1, 1-dimethoxyacetone as raw material, acetylize to obtain 3-methyl-3-hydroxy-4, 4-dimethoxy-1-butyne, selectively hydrogenate with hydrogen to obtain 3-methyl-3-hydroxy-4, 4-dimethoxy-1-butene, esterify with acetic anhydride to obtain 3-methyl-3-acetoxy-4, 4-dimethoxy-1-butene, double bond isomerize under the action of Cu catalyst to obtain 2-methyl-4-acetoxy-1, 1-dimethoxy-2-butene, hydrolyze to remove acetal protecting group to prepare 2-methyl-4-acetoxy-2-butenal, the reaction sequence is depicted as scheme 1 below.
Synthesis scheme 1
Chinese patent document CN102311339A utilizes grignard reagent condensation and acetyl esterification of 1, 1-dimethoxyacetone and vinyl bromide or vinyl chloride to obtain 3-methyl-3-acetoxy-4, 4-dimethoxy-1-butene, which undergoes hydrolysis reaction to obtain 2-methyl-2-acetoxy-3-butene-1-aldehyde, and then undergoes rearrangement reaction under the catalytic action of palladium catalyst or cuprous chloride to obtain 2-methyl-4-acetoxy-2-butenal, the total yield of the last two steps is 73.7-78.1%, and the reaction process is described as the following synthetic route 2.
The 1, 1-dimethoxyacetone used as the raw material of the 1, 1-dimethoxyacetone method has high price, is not easy to obtain and has high cost; the tertiary alcohol intermediate 3-methyl-3-hydroxy-4, 4-dimethoxy-1-butene in the synthetic route 1 has low reaction activity, low selectivity of esterification reaction with acetic anhydride and low yield; the synthesis route 2 needs to prepare a Grignard reagent, has high operation requirement and large wastewater amount; in conclusion, the 1, 1-dimethoxyacetone method is not suitable for industrial application.
2. Ethylene oxide process
U.S. Pat. No. 4,487,3362 describes the following synthetic scheme 3, in which ethylene oxide is used as a raw material, and acetic acid is subjected to a ring-opening reaction to obtain 2-acetoxyethanol, and then the 2-acetoxyethanol is oxidized by oxygen under the action of a silver catalyst to prepare 2-acetoxyacetaldehyde, and then the 2-acetoxyacetaldehyde and propionaldehyde are subjected to an aldol condensation reaction to prepare 2-methyl-4-acetoxy-2-butenal.
In the synthetic route 3, under the action of a silver catalyst, oxygen is used for oxidizing 2-acetoxyl ethanol to prepare 2-acetoxyl acetaldehyde, the reaction selectivity is poor, the side reaction of -step oxidation is more, the 2-acetoxyl acetaldehyde is poor in stability, difficult to store and poor in operability, and in addition, more propionaldehyde self-condensation side reactions are generated during aldol condensation reaction, so that the separation and purification are difficult, and the industrial application is not facilitated.
Chinese patent document CN103467287A describes the following synthetic scheme 4 as a reaction process, in which ethylene oxide is used as a raw material, and undergoes a substitution reaction with acrolein under the catalysis of a phosphine reagent to obtain 2-formyl-4-hydroxy-1-butene, and then undergoes an esterification reaction with an acetylation reagent to obtain 2-formyl-4-acetoxy-1-butene, and then undergoes palladium-catalyzed double bond isomerization to obtain 2-methyl-4-acetoxy-2-butenal, with a total yield of 40.2%.
In the synthetic route 4, a large amount of phosphine reagent catalyst is needed for the reaction of ethylene oxide and acrolein, the cost is high, the toxicity is high, the smell is large, the operation environment is poor, and the industrial production is not facilitated.
3. Isoprene process
U.S. patent documents US4175204 and US5424478, which describe the following synthetic scheme 5, use isoprene as a raw material, and obtain a mixture of 3-methyl-3-hydroxy-4-chloro-1-butene and 1-chloro-2-methyl-4-hydroxy-2-butene through addition reaction with sodium hypochlorite, then prepare 1-chloro-2-methyl-4-acetoxy-2-butene through esterification with acetic anhydride, and then obtain 2-methyl-4-acetoxy-2-butenal through oxidation with DMSO.
The synthetic route 5 has the advantages of large solvent demand, large wastewater quantity, lower DMSO oxidation yield, large odor of the byproduct, larger air pollution, poor repeatability, and generation of a large amount of wastewater, and is not beneficial to green and environment-friendly production.
Chinese patent document CN103012131A uses isoprene as raw material, and reacts with tert-butyl hypochlorite and acetic acid to obtain a mixture of 3-methyl-3-acetoxyl-4-chloro-1-butene and 1-chloro-2-methyl-4-hydroxy-2-butene, then the mixture is esterified with acetic anhydride to prepare 1-chloro-2-methyl-4-acetoxyl-2-butene, the 1-formyloxy-2-methyl-4-acetoxyl-2-butene is obtained by substitution reaction with potassium formate, 1-hydroxy-2-methyl-4-acetoxyl-2-butene is obtained by selective hydrolysis of formate, and then 2-methyl-4-acetoxyl-2-butenal is obtained by TEMPO catalytic oxygen oxidation, the overall yield was 70.5% and the reaction procedure is depicted as scheme 6 below.
Synthesis scheme 6
The synthetic route 6 has long steps, complex operation, large amount of waste water and is not beneficial to environmental protection.
4. 1, 4-butenediol process
U.S. Pat. No. 4,4124619 uses 1, 4-butylene glycol as raw material, and makes it pass through acetic anhydride esterification reaction to obtain 1, 4-diacetyloxy-2-butylene, then makes it react with synthetic gas (CO, H) under the action of rhodium catalyst2) Obtaining 2-formyl-1, 4-diacetyloxy butane through high-pressure reaction, then removing acetic acid under an acidic condition to obtain 2-formyl-4-acetoxyl-1-butene, and obtaining 2-methyl-4-acetoxyl-2-butenal through palladium-catalyzed double bond isomerization, wherein the reaction process is described as the following synthetic route 7.
Synthesis scheme 7
Although the synthetic route 7 has high atom economy, the 1, 4-diacetoxy-2-butene used in the hydroformylation reaction contains two ester functional groups, the substrate activity is low, a special ligand is required, the pressure in the reaction process is high (the pressure is 130-150 atm), the equipment requirement is high, and the method is not suitable for industrial simple and convenient operation.
In conclusion, the research and optimization of the green industrial preparation route of the 2-methyl-4-acetoxyl-2-butenal have important significance for the green production of products such as vitamin A acetate, various carotenoids and the like.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a preparation method of 2-methyl-4-acetoxyl-2-butenal, which has the advantages of cheap and easily-obtained raw materials, low cost, short process flow, easy reaction realization, safe and simple operation, small waste water generation amount, environmental protection, stable reaction intermediate product, proper reaction activity, high reaction selectivity, less side reaction and high yield, and is suitable for industrial production.
Description of terms:
a compound of formula II: 2, 2-disubstituted-4, 7-dihydro-1, 3-dioxepin (II);
a compound of formula III: 2, 2-disubstituted-5-formyl-4, 7-dihydro-1, 3-dioxepin (iii);
a compound of formula IV: 2-formyl-4-acetoxy-1-butene (iv); ac in the structural formula represents acetyl;
a compound of formula I: 2-methyl-4-acetoxyl-2-butenal (I).
In the specification, the compound number and the structural formula number are completely , and have the same reference relationship, and the structural formula of the compound is taken as the basis.
The technical scheme of the invention is as follows:
A process for the preparation of 2-methyl-4-acetoxy-2-butenal (I), comprising the steps of:
(1) preparing a compound of formula iii by subjecting a compound of formula ii and synthesis gas to a hydroformylation reaction;
wherein, in the structural formulas of the compound of the formula II and the compound of the formula III, R1And R2Is hydrogen or alkyl with the number of carbon atoms less than 8; r1And R2The same or different;
(2) preparing a compound of formula iv by reacting a compound of formula iii with an acetylating agent;
(3) 2-methyl-4-acetoxy-2-butenal (I) is prepared by double bond isomerization of the compound of formula IV.
Preferably, according to the invention, in step (1), the hydroformylation of the compound of formula II and synthesis gas is carried out in solvent A, under the action of a rhodium-based catalyst or a rhodium-based catalyst and a cocatalyst.
Preferably, the solvent A is or a combination of more than two of toluene, xylene, benzene, n-hexane, cyclohexane, n-heptane or petroleum ether with the boiling range of 60-90 ℃, the mass ratio of the solvent A to the compound of the formula II is (0.2-15):1, and more preferably , the mass ratio of the solvent A to the compound of the formula II is (0.5-5): 1.
Preferably, the rhodium catalyst is or more of tris (triphenylphosphine) rhodium carbonyl hydride, dicarbonyl (acetylacetone) rhodium, dicarbonyl rhodium chloride or tris (triphenylphosphine) rhodium chloride, the mass of the rhodium catalyst is 0.002-5.0% of the mass of the compound of formula II, further is preferably 0.005-1.5% of the mass of the compound of formula II, and most preferably, the mass of the rhodium catalyst is 0.2-0.8% of the mass of the compound of formula II.
Preferably, the cocatalyst is trialkyl phosphine or triaryl phosphine, preferably triphenylphosphine or tributylphosphine, the mass of the cocatalyst is 0.02-5.0% of the mass of the compound shown in the formula II, further steps are preferred, the mass of the cocatalyst is 0.05-1.5% of the mass of the compound shown in the formula II, and most preferably, the mass of the cocatalyst is 0.2-0.5% of the mass of the compound shown in the formula II.
Preferred according to the invention is, in step (1), a compound of the formula II or a compound of the formula III, in which R is1And R2Is hydrogen, methyl, ethyl, isopropyl, n-propyl or tert-butyl; r1And R2The same or different.
According to a preferred embodiment of the present invention, the synthesis gas of step (1) comprises CO and H as the main components2CO and H2The volume ratio of (A) to (B) is 1: 1; the pressure of the synthesis gas in the reaction system is 0.5-20.0 MPa; preferably, the pressure of the synthesis gas in the reaction system is 2.0-10.0 MPa.
Preferably, according to the invention, in step (1), the hydroformylation reaction temperature is 40 to 150 ℃; preferably, the hydroformylation reaction temperature is 70-110 ℃. The hydroformylation reaction time is 2 to 10 hours; preferably, the hydroformylation reaction time is 4 to 7 hours.
Preferably, according to the invention, in step (2), the reaction of the compound of formula III with the acetylating agent is carried out in solvent B in the presence of water and in the presence of catalyst C.
Preferably, the solvent B is or the combination of more than two of water, toluene, xylene, benzene, normal hexane, cyclohexane, normal heptane or petroleum ether with the boiling range of 60-90 ℃, the mass ratio of the solvent B to the compound of the formula III is (1-15):1, and more preferably , the mass ratio of the solvent B to the compound of the formula III is (1.5-5): 1.
Preferably, the mass of water is 0.5-2% of the mass of the compound of formula III.
Preferably, the catalyst C is or the combination of more than two of benzene sulfonic acid, p-methyl benzene sulfonic acid, methyl sulfonic acid or concentrated sulfuric acid with the mass concentration of 70-98%, the mass of the catalyst C is 0.02-2.0% of the mass of the compound of the formula III, and further is preferred, the mass of the catalyst is 0.1-1.0% of the mass of the compound of the formula III.
Preferably according to the invention, in step (2), the acetylating agent is acetic acid; the molar ratio of the acetylation reagent to the compound of formula III is (1.0-3.2): 1; preferably, the molar ratio of the acetylating agent to the compound of formula III is (1.3-2.0): 1.
Preferably, according to the invention, in step (2), the temperature for reacting the compound of formula III and the acetylating agent is 60-140 ℃; preferably, the temperature for the reaction of the compound of formula III and the acetylating agent is 100-120 ℃. The reaction time of the compound shown in the formula III and an acetylation reagent is 1-10 hours; preferably, the compound of formula III and the acetylating agent are reacted for a period of time in the range of 3 to 6 hours.
Preferably, according to the invention, in step (3), the double bond isomerization of the compound of formula IV is carried out in the presence of hydrogen in the presence of the catalyst E and the poisoning agent in the solvent D.
Preferably, the solvent D is toluene or xylene, the mass ratio of the solvent D to the compound shown in the formula IV is (1-10):1, and further , preferably, the mass ratio of the solvent D to the compound shown in the formula IV is (2-5): 1.
Preferably, before introducing the hydrogen into the system, the inert gas is introduced to the system until the pressure of the system is 5.0-5.2MPa, and then the hydrogen is introduced to the system until the pressure of the system is 5.5-6.0 MPa. The purpose of introducing hydrogen is as follows: because the isomerization process involves hydrogenation of carbon-carbon double bonds and dehydrogenation of carbon-carbon single bonds, equilibrium is eventually reached, resulting in isomerization of the carbon-carbon double bonds to between the 2, 3-position carbon atoms; the hydrogen amount is not too large, and a poisoning agent tetramethyl thiourea is needed to avoid the hydrogenation of carbon-carbon double bonds in the target product.
Preferably, the catalyst E is palladium carbon with the mass content of palladium being 5%, the mass of the catalyst E is 1.0-10.0% of that of the compound shown in the formula IV, and further , the mass of the catalyst E is 1.0-4.0% of that of the compound shown in the formula IV.
Preferably, the poisoning agent is a thiol, thioether, or thiourea derivative, and further preferably, the thiol has the formula CnH2n+1SH (4 ≦ n ≦ 12), preferably butylmercaptan or octylmercaptan; the thioethers have the general formula CnH2n+1SCmH2m+1(4 ≦ n ≦ 12, 4 ≦ m ≦ 12, n and m are the same or different), preferably butyl sulfide or di-n-octyl sulfide; the thiourea derivative is tetramethyl thiourea.
Preferably, the mass of the poisoning agent is 2.0 to 5.0% of the mass of the catalyst E.
Preferably, according to the invention, in the step (3), the double bond isomerization reaction temperature is 60-140 ℃; preferably, the double bond isomerization reaction temperature is 90-110 ℃. The double bond isomerization reaction time is 3-10 hours; preferably, the double bond isomerization reaction time is 5 to 8 hours.
The present invention is depicted as scheme 8 below:
scheme 8
Wherein, in the structural formulas of the compound of the formula II and the compound of the formula III, R1And R2Is hydrogen or alkyl with the number of carbon atoms less than 8; r1And R2The same or different.
The invention has the technical characteristics and beneficial effects that:
1. the invention provides a preparation method of 2-methyl-4-acetoxyl-2-butenal (I). the invention utilizes 2, 2-disubstituted-4, 7-dihydro-1, 3-dioxaheptin (II) and synthesis gas to prepare 2, 2-disubstituted-5-formyl-4, 7-dihydro-1, 3-dioxaheptin (III) through hydroformylation reaction under the action of a catalyst, then the 2-formyl-4-acetoxyl-1-butene (IV) is prepared through reaction with an acetylation reagent under the action of the catalyst, and then the 2-methyl-4-acetoxyl-2-butenal (I) is obtained through double bond isomerization under the action of the catalyst.
2. The method has the advantages of cheap and easily obtained raw materials and low cost; the method is simple and short in process flow, and the target product can be prepared only by 3 steps; the reaction does not need high pressure, the reaction is easy to realize, the operation is safe and simple, the waste water generation amount in the reaction process is small, and the method is green and environment-friendly; the reaction intermediate has good stability and proper reaction activity, does not need special coordination, the used raw material 2, 2-disubstituted-4, 7-dihydro-1, 3-dioxaheptin does not contain a carbonyl functional group, the complexation of carbonyl and a rhodium catalyst is avoided, the target hydroformylation reaction is easy to carry out, and the used rhodium catalyst has small dosage, low reaction pressure and easy operation; the method has the advantages of high atom economy, high reaction selectivity, less side reaction, high yield, total yield of 86.8 percent and purity of 99.8 percent, and is suitable for green industrial production.
3. The 2, 2-disubstituted-5-formyl-4, 7-dihydro-1, 3-dioxaheptin (III) and an acetylation reagent are subjected to esterification reaction under the action of a catalyst and a trace amount of water to obtain the 2-formyl-1, 4-diacetyloxybutane, and molecules of acetic acid are easily removed from the intermediate to generate the 2-formyl-4-acetoxyl-1-butene (IV), so that the reaction is promoted to be carried out.
4. The method has the advantages of high stability of the used raw material 2, 2-disubstituted-4, 7-dihydro-1, 3-dioxepin, no carbonyl functional group which is easy to complex with a hydroformylation reaction catalyst, easiness in operation of the hydroformylation reaction, low reaction pressure, high selectivity of the hydroformylation reaction and high product yield, preparing the 2-formyl-4-acetoxyl-1-butene through an acetylation reagent under the action of trace water and the catalyst, ensuring the stability of the product and reducing hydrolysis, finally obtaining the 2-methyl-4-acetoxyl-2-butenal through double bond isomerization and rectification separation under the action of the catalyst, recovering the unreacted 2-formyl-4-acetoxyl-1-butene, and using the recovered 2-formyl-4-acetoxyl-1-butene for the next batch isomerization reaction, along with proper reaction activity, easiness in reaction, special selectivity , and guarantee of the stability of the raw material and the product and guarantee of high yield and high purity of the target product.
Drawings
FIG. 1 is a gas chromatogram of 2-methyl-4-acetoxy-2-butenal (I) prepared in example 5.
FIG. 2 is a nuclear magnetic spectrum of 2-methyl-4-acetoxy-2-butenal (I) prepared in example 5.
Detailed Description
The present invention is described in detail below with reference to examples, but the present invention is not limited thereto.
The raw materials and reagents used in the examples are all commercially available products.
In the examples, "%" is a mass percentage unless otherwise specified.
The yields in the examples are all molar yields.
Example 1: preparation of 2-methyl-2-ethyl-5-formyl-4, 7-dihydro-1, 3-dioxepin (III 1)
142.0 g (1.0 mol) of 2-methyl-2-ethyl-4, 7-dihydro-1, 3-dioxaheptin (II 1), 150.0 g of toluene, 0.8 g of tris (triphenylphosphine) carbonyl rhodium hydride, 0.5 g of triphenylphosphine, a closed pressure kettle, and a nitrogen gas in the kettle replaced 3 times, then a synthetic gas CO/H is introduced into a 500 ml stainless steel autoclave connected with a stirring thermometer2(volume ratio 1:1), keeping the pressure of the synthesis gas at 4.0-5.0MPa, starting stirring, heating to 95-100 ℃, reacting for 4 hours, cooling, replacing for 3 times by nitrogen, removing the reaction liquid, washing the reaction kettle by 30 g of toluene, filtering to remove the catalyst, distilling the filtrate to recover the toluene, and distilling under reduced pressure (110 ℃ C./1-2 mmHg) to obtain 160.5 g of 2-methyl-2-ethyl-5-formyl-4, 7-dihydro-1, 3-dioxaheptin (III 1), wherein the yield is 93.3 percent and the gas phase purity is 99.6 percent.
Example 2: preparation of 2-methyl-2-tert-butyl-5-formyl-4, 7-dihydro-1, 3-dioxepin (III 2)
Into a 500 ml stainless steel autoclave equipped with a stirrer and a thermometer were charged 170.0 g (1.0 mol) of 2-methyl-2-tert-butyl-4, 7-dihydro-1, 3-dioxaheptin (II 2), 120 g of toluene, 0.9 g of tris (triphenylphosphine) rhodium chloride, 0.6 g of triphenylphosphine, a closed autoclave, and nitrogen gasReplacing gas in the kettle for 3 times, and introducing synthetic gas CO/H2(volume ratio 1:1), keeping the pressure of the synthesis gas at 5.0-6.0MPa, starting stirring, heating to 100 ℃ and 105 ℃, reacting for 5 hours, cooling, replacing for 3 times by nitrogen, removing reaction liquid, washing the reaction kettle by 30 g of toluene, filtering to remove the catalyst, distilling the filtrate to recover the toluene, and distilling under reduced pressure (110 ℃ at 125 ℃/1-2mmHg) to obtain 183.2 g of 2-methyl-2-tert-butyl-5-formyl-4, 7-dihydro-1, 3-dioxaheptin (III 2), wherein the yield is 91.6 percent and the gas phase purity is 99.7 percent.
Example 3: preparation of 2-formyl-4-acetoxy-1-butene (IV)
Into a 500 ml four-necked flask equipped with a stirrer, a thermometer and a reflux condenser, 200 g of toluene, 86.0 g (0.5 mol) of 2-methyl-2-ethyl-5-formyl-4, 7-dihydro-1, 3-dioxepin (III 1) prepared in example 1, 48.0 g (0.8 mol) of acetic acid, 1.0 g of water, 0.3 g of p-toluenesulfonic acid, and stirred at 112 ℃ for 5 hours to react, while collecting the by-product 2-butanone. The reaction mixture was cooled to 20 to 25 ℃ and the distillation system was changed to recover toluene and excess acetic acid by distillation, followed by high vacuum distillation under reduced pressure (85-100 ℃ C./1-2 mmHg) to give 67.6 g of 2-formyl-4-acetoxy-1-butene (IV) in 95.2% yield and 99.5% purity in the vapor phase.
Example 4: preparation of 2-formyl-4-acetoxy-1-butene (IV)
Into a 500 ml four-necked flask equipped with a stirrer, a thermometer and a reflux condenser, 200 g of toluene, 100.0 g (0.5 mol) of 2-methyl-2-tert-butyl-5-formyl-4, 7-dihydro-1, 3-dioxepin (III 2) prepared in example 2, 48.0 g (0.8 mol) of acetic acid, 1.0 g of water, 0.15 g of benzenesulfonic acid, and 100 ℃ were stirred and reacted at 105 ℃ for 6 hours. Cooling to 20-25 deg.c, changing into distillation system, distilling to recover toluene and excess acetic acid, then changing into high vacuum reduced pressure distillation (85-100 deg.c/1-2 mmHg) to obtain 68.2 g 2-formyl-4-acetoxy-1-butene (iv), yield is 96.1%, gas phase purity is 99.3%.
Example 5: preparation of 2-methyl-4-acetoxyl-2-butenal (I)
71.0 g (0.5 mol) of 2-formyl-4-acetoxyl-1-butene (IV) prepared by the method of example 4, 150 g of toluene, 1.2 g of 5 wt% palladium carbon, 0.04 g of tetramethylthiourea are added into a 500 ml stainless steel autoclave connected with a stirring thermometer, the pressure kettle is sealed, the gas in the autoclave is replaced by nitrogen for 3 times, the temperature is increased to 105 ℃ of 100- Acetoxy-2-butenal (I) in a yield of 98.6% (based on the compound IV participating in the reaction).
FIG. 1 is a gas chromatogram of the product obtained in this example, and it can be seen from FIG. 1 that the product obtained in this example has a gas phase purity of 99.2%.
The nuclear magnetic spectrum of the product obtained in this example is shown in fig. 2, and the nuclear magnetic data is as follows:
1HNMR(400MHz,CDCl3):δppm
9.42(s,1H),6.46-6.48(t,1H),4.86-4.89(d,2H),2.09(s,3H),1.77(s,3H)。
as can be seen from the above, the product obtained by the invention is the target product 2-methyl-4-acetoxyl-2-butenal (I).
Example 6: preparation of 2-methyl-4-acetoxyl-2-butenal (I)
Adding 71.0 g (0.5 mol) of 2-formyl-4-acetoxyl-1-butene (IV) prepared by the method of example 3, 150 g of toluene, 1.2 g of 5 wt% palladium carbon and 0.04 g of di-n-octyl sulfide into a 500 ml stainless steel autoclave connected with a stirring thermometer, sealing the autoclave, replacing the gas in the autoclave with nitrogen for 3 times, heating to 100-105 ℃, keeping the pressure in the autoclave at 5.0-5.2MPa, slightly introducing hydrogen until the pressure in the autoclave is 5.5-6.0MPa, stirring and reacting at the temperature of 100-105 ℃ for 6 hours, cooling, replacing with nitrogen for 3 times, removing the reaction liquid, washing the autoclave with 30 g of toluene, filtering to remove the catalyst, distilling the filtrate to recover the toluene, and performing rectification under reduced pressure (75-105 ℃/1-2) to obtain 17.8 g of 2-formyl-4-acetoxyl-1-butene (IV) and 51.6 g of 2-methyl-4-acetyl-1-butene (IV) Acetoxy-2-butenal (I) in 97.0% yield (based on the compound IV participating in the reaction) and in a gas phase purity of 99.8%.
Comparative example: preparation of 2-methyl-2-ethyl-5-formyl-4, 7-dihydro-1, 3-dioxepin (III 1)
142.0 g (1.0 mol) of 2-methyl-2-ethyl-4, 7-dihydro-1, 3-dioxaheptin (II 1), 150.0 g of toluene and 1.0 g of tris (triphenylphosphine) carbonyl rhodium hydride are added into a 500 ml stainless steel autoclave connected with a stirring thermometer, the autoclave is sealed, the gas in the autoclave is replaced by nitrogen for 3 times, and then synthesis gas CO/H is introduced2(volume ratio 1:1), keeping the pressure of the synthesis gas at 4.0-5.0MPa, starting stirring, heating to 95-100 ℃, reacting for 5 hours, cooling, replacing 3 times with nitrogen, removing the reaction liquid, washing the reaction kettle with 30 g of toluene, filtering to remove the catalyst, distilling the filtrate to recover the toluene, and performing reduced pressure distillation (110 ℃ C./1-2 mmHg) to obtain 47.4 g (1.0 mol) of 2-methyl-2-ethyl-4, 7-dihydro-1, 3-dioxepin (II 1) and 105.6 g of 2-methyl-2-ethyl-5-formyl-4, 7-dihydro-1, 3-dioxepin (III 1), wherein the yield is 92.2% (calculated by the actual II 1 participating in the reaction) and the gas phase purity is 98.1%.
The comparative example shows that the addition of the cocatalyst is beneficial to ensuring the stability of the main catalyst, reducing the decomposition of the main catalyst and being beneficial to the thorough reaction of the raw materials.
Claims (10)
- A process for the preparation of kinds of 2-methyl-4-acetoxy-2-butenal (I), comprising the steps of:(1) preparing a compound of formula iii by subjecting a compound of formula ii and synthesis gas to a hydroformylation reaction;wherein, in the structural formulas of the compound of the formula II and the compound of the formula III, R1And R2Is hydrogen or alkyl with the number of carbon atoms less than 8; r1And R2The same or different;(2) preparing a compound of formula iv by reacting a compound of formula iii with an acetylating agent;
(3) 2-methyl-4-acetoxy-2-butenal (I) is prepared by double bond isomerization of the compound of formula IV. - 2. The process for the preparation of 2-methyl-4-acetoxy-2-butenal (i) according to claim 1, wherein the hydroformylation of the compound of formula ii with synthesis gas in step (1) is carried out in a solvent a under the action of a rhodium-based catalyst or a rhodium-based catalyst and a cocatalyst.
- 3. The process for the preparation of 2-methyl-4-acetoxy-2-butenal (i) according to claim 2, which comprises or more of the following conditions:a. the solvent A is or the combination of more than two of toluene, xylene, benzene, normal hexane, cyclohexane, normal heptane or petroleum ether with the boiling range of 60-90 ℃, the mass ratio of the solvent A to the compound of the formula II is (0.2-15) to 1, preferably, the mass ratio of the solvent A to the compound of the formula II is (0.5-5) to 1;b. the rhodium catalyst is or the combination of more than two of tris (triphenylphosphine) carbonyl rhodium hydride, dicarbonyl (acetylacetone) rhodium, dicarbonyl rhodium chloride or tris (triphenylphosphine) rhodium chloride, the mass of the rhodium catalyst is 0.002-5.0 percent of that of the compound of the formula II, preferably, the mass of the rhodium catalyst is 0.005-1.5 percent of that of the compound of the formula II, and most preferably, the mass of the rhodium catalyst is 0.2-0.8 percent of that of the compound of the formula II;c. the cocatalyst is trialkyl phosphine or triaryl phosphine, preferably triphenylphosphine or tributylphosphine; the mass of the cocatalyst is 0.02-5.0% of the mass of the compound of the formula II; preferably, the mass of the cocatalyst is 0.05-1.5% of the mass of the compound of formula II; most preferably, the mass of the cocatalyst is 0.2-0.5% of the mass of the compound of formula II.
- 4. The process for producing 2-methyl-4-acetoxy-2-butenal (i) according to claim 1, wherein the step (1) comprises or more of the following conditions:a. in the structural formulae of the compounds of the formulae II and III, R1And R2Is hydrogen, methyl, ethyl, isopropyl, n-propyl or tert-butyl; r1And R2The same or different;b. the main components of the synthesis gas are CO and H2CO and H2The volume ratio of (A) to (B) is 1: 1; the pressure of the synthesis gas in the reaction system is 0.5-20.0 MPa; preferably, the pressure of the synthesis gas in the reaction system is 2.0-10.0 MPa;c. the hydroformylation reaction temperature is 40-150 ℃; preferably, the hydroformylation reaction temperature is 70-110 ℃.
- 5. The process for the preparation of 2-methyl-4-acetoxy-2-butenal (i) according to claim 1, wherein in the step (2), the reaction of the compound of the formula iii with the acetylating agent is carried out in the presence of water in the presence of a catalyst C in a solvent B.
- 6. The process for the preparation of 2-methyl-4-acetoxy-2-butenal (i) according to claim 5, which comprises or more of the following conditions:a. the solvent B is or the combination of more than two of water, toluene, xylene, benzene, n-hexane, cyclohexane, n-heptane or petroleum ether with the boiling range of 60-90 ℃, the mass ratio of the solvent B to the compound shown in the formula III is (1-15) to 1, preferably, the mass ratio of the solvent B to the compound shown in the formula III is (1.5-5) to 1;b. the mass of the water is 0.5-2% of that of the compound shown in the formula III;c. the catalyst C is or the combination of more than two of benzene sulfonic acid, p-methyl benzene sulfonic acid, methyl sulfonic acid or concentrated sulfuric acid with the mass concentration of 70-98%, the mass of the catalyst C is 0.02-2.0% of the mass of the compound of the formula III, and preferably, the mass of the catalyst is 0.1-1.0% of the mass of the compound of the formula III.
- 7. The process for producing 2-methyl-4-acetoxy-2-butenal (i) according to claim 1, wherein the step (2) comprises or more of the following conditions:a. the acetylation reagent is acetic acid; the molar ratio of the acetylation reagent to the compound of formula III is (1.0-3.2): 1; preferably, the molar ratio of the acetylating agent to the compound of formula III is (1.3-2.0): 1;b. the reaction temperature of the compound shown in the formula III and an acetylation reagent is 60-140 ℃; preferably, the temperature for the reaction of the compound of formula III and the acetylating agent is 100-120 ℃.
- 8. The process for the preparation of 2-methyl-4-acetoxy-2-butenal (i) according to claim 1, wherein the double bond isomerization of the compound of the formula iv in the step (3) is carried out in a solvent D in the presence of hydrogen and in the presence of a catalyst E and a poisoning agent.
- 9. The process for the preparation of 2-methyl-4-acetoxy-2-butenal (i) according to claim 8, which comprises or more of the following conditions:a. the solvent D is toluene or xylene; the mass ratio of the solvent D to the compound shown in the formula IV is (1-10) to 1; preferably, the mass ratio of the solvent D to the compound shown in the formula IV is (2-5): 1;b. before introducing hydrogen into the system, introducing inert gas until the pressure of the system is 5.0-5.2MPa, and then introducing hydrogen until the pressure of the system is 5.5-6.0 MPa;c. the catalyst E is palladium carbon with the mass content of palladium being 5 percent; the mass of the catalyst E is 1.0-10.0% of that of the compound shown in the formula IV; preferably, the mass of the catalyst E is 1.0-4.0% of the mass of the compound of formula IV;d. the poisoning agent is a thiol, thioether or thiourea derivative; preferably, the thiol has the formula CnH2n+1SH(4≦n≦12) Preferably butanethiol or octanethiol; the thioethers have the general formula CnH2n+1SCmH2m+1(4 ≦ n ≦ 12, 4 ≦ m ≦ 12, n and m are the same or different), preferably butyl sulfide or di-n-octyl sulfide; the thiourea derivative is tetramethyl thiourea;e. the mass of the poisoning agent is 2.0 to 5.0% of the mass of the catalyst E.
- 10. The process for producing 2-methyl-4-acetoxy-2-butenal (I) according to claim 1, wherein in the step (3), the double bond isomerization reaction temperature is 60 to 140 ℃; preferably, the double bond isomerization reaction temperature is 90-110 ℃.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113603592A (en) * | 2021-06-29 | 2021-11-05 | 万华化学集团股份有限公司 | Preparation method of 2-methyl-4-acetoxyl-2-butenal with thermal stability |
| CN113603587A (en) * | 2021-06-29 | 2021-11-05 | 万华化学集团股份有限公司 | Preparation method of 2-methyl-4-acetoxyl-2-butenal with stable chromaticity |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102311339A (en) * | 2011-06-30 | 2012-01-11 | 绍兴文理学院 | Method for preparing 4-acetoxy-2-methyl-2-butene-1-aldehyde |
| CN103467287A (en) * | 2013-09-27 | 2013-12-25 | 上虞新和成生物化工有限公司 | Preparation method for 4-acetoxyl-2-methyl-2-butenal |
| CN105968008A (en) * | 2016-07-25 | 2016-09-28 | 福建福尔金生物科技有限公司 | Synthetic method of trans-4-acetoxyl-2-methyl-2-butene-1-aldehyde |
| CN107286017A (en) * | 2017-06-17 | 2017-10-24 | 安徽智新生化有限公司 | A kind of preparation method of the aldehyde of 4 acetoxyl group, 2 methyl, 2 butylene 1 |
| CN109836374A (en) * | 2017-11-28 | 2019-06-04 | 新发药业有限公司 | A kind of vitamin B6Environment-friendly preparation method |
-
2018
- 2018-07-20 CN CN201810802768.9A patent/CN110734376B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102311339A (en) * | 2011-06-30 | 2012-01-11 | 绍兴文理学院 | Method for preparing 4-acetoxy-2-methyl-2-butene-1-aldehyde |
| CN103467287A (en) * | 2013-09-27 | 2013-12-25 | 上虞新和成生物化工有限公司 | Preparation method for 4-acetoxyl-2-methyl-2-butenal |
| CN105968008A (en) * | 2016-07-25 | 2016-09-28 | 福建福尔金生物科技有限公司 | Synthetic method of trans-4-acetoxyl-2-methyl-2-butene-1-aldehyde |
| CN107286017A (en) * | 2017-06-17 | 2017-10-24 | 安徽智新生化有限公司 | A kind of preparation method of the aldehyde of 4 acetoxyl group, 2 methyl, 2 butylene 1 |
| CN109836374A (en) * | 2017-11-28 | 2019-06-04 | 新发药业有限公司 | A kind of vitamin B6Environment-friendly preparation method |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113603592A (en) * | 2021-06-29 | 2021-11-05 | 万华化学集团股份有限公司 | Preparation method of 2-methyl-4-acetoxyl-2-butenal with thermal stability |
| CN113603587A (en) * | 2021-06-29 | 2021-11-05 | 万华化学集团股份有限公司 | Preparation method of 2-methyl-4-acetoxyl-2-butenal with stable chromaticity |
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Denomination of invention: A preparation method of 2-methyl-4-acetoxy-2-butenal Effective date of registration: 20231130 Granted publication date: 20220401 Pledgee: Dongying Branch of China CITIC Bank Co.,Ltd. Pledgor: Xinfa pharmaceutical Co.,Ltd. Registration number: Y2023980068537 |