CN110731351A - environment-friendly easy-to-clean sterilization and preservation composition and preparation method thereof - Google Patents
environment-friendly easy-to-clean sterilization and preservation composition and preparation method thereof Download PDFInfo
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- CN110731351A CN110731351A CN201911024034.3A CN201911024034A CN110731351A CN 110731351 A CN110731351 A CN 110731351A CN 201911024034 A CN201911024034 A CN 201911024034A CN 110731351 A CN110731351 A CN 110731351A
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- Prior art keywords
- nano
- silver
- solution
- biosurfactant
- titanium dioxide
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- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 52
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 35
- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 238000004321 preservation Methods 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 230000003670 easy-to-clean Effects 0.000 title claims abstract description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 55
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 43
- 239000003876 biosurfactant Substances 0.000 claims abstract description 32
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 25
- 230000003385 bacteriostatic effect Effects 0.000 claims abstract description 24
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 10
- MFPVDOIQNSMNEW-UHFFFAOYSA-N silver oxygen(2-) titanium(4+) Chemical class [O--].[O--].[Ti+4].[Ag+] MFPVDOIQNSMNEW-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000003960 organic solvent Substances 0.000 claims abstract description 5
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 67
- 239000000243 solution Substances 0.000 claims description 33
- 239000011159 matrix material Substances 0.000 claims description 31
- 239000002245 particle Substances 0.000 claims description 26
- 239000000725 suspension Substances 0.000 claims description 26
- 239000002131 composite material Substances 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 21
- 239000004094 surface-active agent Substances 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 238000003756 stirring Methods 0.000 claims description 20
- 230000000844 anti-bacterial effect Effects 0.000 claims description 15
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 15
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 15
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 15
- -1 silver-titanium dioxide compound Chemical class 0.000 claims description 15
- 239000008367 deionised water Substances 0.000 claims description 14
- 229910021641 deionized water Inorganic materials 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- 235000013399 edible fruits Nutrition 0.000 claims description 13
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 claims description 11
- 235000012239 silicon dioxide Nutrition 0.000 claims description 11
- 239000006184 cosolvent Substances 0.000 claims description 10
- 239000011259 mixed solution Substances 0.000 claims description 10
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 239000000645 desinfectant Substances 0.000 claims description 9
- 229920000136 polysorbate Polymers 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 229930186217 Glycolipid Natural products 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 6
- 239000002002 slurry Substances 0.000 claims description 6
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims description 5
- 239000012752 auxiliary agent Substances 0.000 claims description 5
- 230000000249 desinfective effect Effects 0.000 claims description 5
- 239000012046 mixed solvent Substances 0.000 claims description 5
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
- 229920000053 polysorbate 80 Polymers 0.000 claims description 4
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical group [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 claims description 2
- 238000013329 compounding Methods 0.000 claims description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000002270 dispersing agent Substances 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 235000013311 vegetables Nutrition 0.000 claims description 2
- UJEADPSEBDCWPS-SGJODSJKSA-N (2R,3R)-1-[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]butane-1,2,3,4-tetrol Chemical class C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)C([C@H](O)[C@H](O)CO)O UJEADPSEBDCWPS-SGJODSJKSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 description 13
- 239000003242 anti bacterial agent Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titanium dioxide Inorganic materials O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 6
- 230000004580 weight loss Effects 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 241000227653 Lycopersicon Species 0.000 description 4
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 230000010355 oscillation Effects 0.000 description 4
- 229910052709 silver Inorganic materials 0.000 description 4
- 239000004332 silver Substances 0.000 description 4
- ZTOKUMPYMPKCFX-CZNUEWPDSA-N (E)-17-[(2R,3R,4S,5S,6R)-6-(acetyloxymethyl)-3-[(2S,3R,4S,5S,6R)-6-(acetyloxymethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxyoctadec-9-enoic acid Chemical compound OC(=O)CCCCCCC/C=C/CCCCCCC(C)O[C@@H]1O[C@H](COC(C)=O)[C@@H](O)[C@H](O)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](COC(C)=O)O1 ZTOKUMPYMPKCFX-CZNUEWPDSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 239000012876 carrier material Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 235000012055 fruits and vegetables Nutrition 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 231100000956 nontoxicity Toxicity 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 229920001661 Chitosan Polymers 0.000 description 2
- 241001672694 Citrus reticulata Species 0.000 description 2
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- LJQKCYFTNDAAPC-UHFFFAOYSA-N ethanol;ethyl acetate Chemical compound CCO.CCOC(C)=O LJQKCYFTNDAAPC-UHFFFAOYSA-N 0.000 description 2
- 239000007888 film coating Substances 0.000 description 2
- 238000009501 film coating Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 238000003760 magnetic stirring Methods 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 230000001699 photocatalysis Effects 0.000 description 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 241000228143 Penicillium Species 0.000 description 1
- 241000233639 Pythium Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 229940083025 silver preparation Drugs 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000005068 transpiration Effects 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
- A23B7/00—Preservation or chemical ripening of fruit or vegetables
- A23B7/14—Preserving or ripening with chemicals not covered by groups A23B7/08 or A23B7/10
- A23B7/153—Preserving or ripening with chemicals not covered by groups A23B7/08 or A23B7/10 in the form of liquids or solids
- A23B7/154—Organic compounds; Microorganisms; Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
- A23B7/00—Preservation or chemical ripening of fruit or vegetables
- A23B7/14—Preserving or ripening with chemicals not covered by groups A23B7/08 or A23B7/10
- A23B7/153—Preserving or ripening with chemicals not covered by groups A23B7/08 or A23B7/10 in the form of liquids or solids
- A23B7/157—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
- A23B7/00—Preservation or chemical ripening of fruit or vegetables
- A23B7/16—Coating with a protective layer; Compositions or apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention relates to environment-friendly and easy-to-clean type sterilization and preservation compositions and a preparation method thereof, wherein the compositions mainly comprise mesoporous silica-loaded nano silver-titanium dioxide compounds, hydrogen peroxide, bacteriostatic biosurfactants, organic solvents, emulsifiers and the like.
Description
Technical Field
The invention belongs to the technical field of disinfectant preparation, and particularly relates to composite disinfectant and bactericide preparations loaded with nano-silver as well as a preparation method and application thereof.
Background
The nano silver preparation has strong antibacterial capability, has a spectrum antibacterial effect, can not be accumulated in a human body to generate toxicity, can be used as an antibacterial active material for a long time, is an ideal safe environment-friendly antibacterial agent of types, and can even be used in the field of fruit preservation.
The prior art discloses a plurality of preparation methods of nano silver and application of nano silver in disinfection and sterilization of various objects, but reports of nano silver in food such as fruits are less.
The general fresh-keeping of fruits has physical and chemical fresh-keeping technologies, such as refrigeration, decompression or vacuum storage, and the chemical fresh-keeping technology uses a chemical fresh-keeping agent, but with more and more attention paid to the complete problem of foods, the chemical fresh-keeping agent is gradually abandoned, and a high-efficiency and nontoxic safe and environment-friendly fresh-keeping agent is sought, because the nano-silver is a nano-material with silver particles in a nano size, the nano-silver has unique properties of the nano-material and has the characteristics of bacteriostasis, catalysis and the like of metal silver, the nano-silver can be used as an inorganic antibacterial agent and has an application prospect of in food fresh-keeping, however, although the nano-silver antibacterial agent has a good effect and is widely applied to the surface disinfection of objects such as ceramics and the like by , the adverse factors of heavy metals on human health and the color of the metals can influence the appearance of products, and the application.
Therefore, at present, a safe, non-toxic and easily-washed nano-silver composite preparation formulation is still lacked, and the nano-silver composite preparation formulation is used for disinfecting, sterilizing and preserving the surfaces of various objects so as to inhibit the breeding of various moulds and bacteria on the surfaces of various objects including fruits.
Currently, another inorganic antimicrobial agents commonly used are metal oxide antimicrobial agents such as Ti02ZnO, etc. Wherein Ti02The photocatalytic antibacterial agent is typical of catalytic antibacterial agents, has the advantages of strong stability, no toxic or side effect, spectral antibacterial effect and the like, and can be used for photocatalytic sterilization and decomposition of toxins secreted by bacteria. Is suitable for being used as a component of the slow-release inorganic antibacterial agent.
In addition, in the prior art, the glycolipid biosurfactant has the advantages of no toxicity, biodegradability, environmental friendliness and the like, and has good application prospects in the aspects of environmental protection, food, cosmetics, detergents, medicines and the like, and many documents report that kinds of glycolipids have bacteriostatic action.
The conventional silver-containing sterilizing and freshness-retaining agents are listed below.
CN2010102577566 discloses kinds of environment-friendly sterilizing, disinfecting and antistaling agents, which are formed by mixing a hydrogen peroxide solution and a colloidal silver solution, wherein the colloidal silver is mainly used as a hydrogen peroxide stabilizer, so that the problems of poor stability and poor sterilizing effect of a pure hydrogen peroxide product are solved, and the main sterilizing component is hydrogen peroxide.
The invention relates to a nano-silver composite antistaling agent and a research on the fresh-keeping of Nanfeng mandarin orange (Nanchang university, Lepan). The Nanfeng mandarin orange fruit antistaling agent is disclosed, which is prepared by mixing 1 percent of carboxymethyl chitosan, 1 percent of chitosan and glycerol according to a proportion of to prepare a pure clear solution, and then adding quantitative nano-silver zirconium oxide into the pure clear solution to prepare the nano-silver composite antistaling agent.
CN201410746810 discloses multifunctional nano-silver antibacterial agents, which are characterized in that the mass percent of silver nitrate is 0.5-2%, the mass percent of reducing agent is 0.5-2%, the mass percent of gellan gum is 0.2-1.3%, the mass percent of surfactant is 2.5-4%, the mass percent of auxiliary agent is 1.5-3%, and the mass percent of 75% alcohol is 79.7-93.8%.
However, the research on the sterilizing surfactant disinfectant preparation compounded with nano-silver is not reported.
Therefore, in order to expand the disinfection and preservation application of nano-silver, novel safe, nontoxic and easy-to-clean nano-silver composite preparations are needed to be developed for disinfection or preservation of objects including fruits.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides environment-friendly and easy-to-clean sterilization and preservation compositions and a preparation method thereof.
The specific technical scheme of the invention is as follows.
, the invention provides environment-friendly and easy-to-clean sterilization and preservation compositions, which mainly comprise the following components:
1) and (2) component A: a nano silver-titanium dioxide compound loaded by mesoporous silica, and hydrogen peroxide.
2) And (B) component: bacteriostatic biosurfactant, organic solvent and emulsifier.
Wherein, the bacteriostatic biosurfactant is preferably degradable glycolipid biosurfactant;
the organic solvent at least comprises ethanol;
the emulsifier is selected from tween.
3) Auxiliary components, including deionized water and suitable auxiliaries, such as film formers, cosolvents, dispersants or stabilizers.
Wherein, preferably, the auxiliary agent is selected from polyvinylpyrrolidone.
In a second aspect, the invention provides a preparation method of the environment-friendly easy-cleaning type sterilization and preservation composition, which comprises the following steps 1) to 4):
step 1): preparing a silicon dioxide loaded nano silver particle compound suspension from the nano silver slurry and mesoporous silicon dioxide particles, adding a proper amount of nano titanium dioxide, vibrating and stirring to prepare a mesoporous silicon dioxide loaded nano silver-titanium dioxide compound suspension.
The specific process is as follows:
s1: adding nano-silver particles into distilled water to prepare nano-silver slurry with the mass fraction of 1-5%, adding mesoporous silica particles with the mass of 5-20 times that of the nano-silver, stirring the mixed solution on a magnetic stirrer for 15-30min, then ultrasonically oscillating the mixed solution in an ultrasonic oscillator for 5-15min, and then standing and adsorbing the mixed solution for 30min to obtain a nano-silver particle composite suspension loaded by the mesoporous silica;
s2: adding nano titanium dioxide into the prepared silica-loaded nano silver particle composite suspension, magnetically and rapidly stirring for 15-25min at 50-60 ℃, and then oscillating and adsorbing for 30-60min by a 100-plus-200 rpm shaking table to obtain the mesoporous silica-loaded nano silver-titanium dioxide composite suspension.
Wherein, the addition amount of the nano titanium dioxide particles is 5-10 times of the mass of the nano silver, and the particle size is 5-100 nm.
Wherein the particle size of the nano silver particles is in the range of 10-100nm, preferably 10-50 nm; the particle size of the mesoporous silica microsphere is 30-500nm (preferably 50-300nm), and the pore diameter is 10-50 nm.
Step 2): and mixing the prepared supported nano silver-titanium dioxide compound suspension and a hydrogen peroxide solution or a hydrogen peroxide colloidal silver ion solution, and uniformly stirring to obtain the disinfection matrix solution.
In the step, the mass ratio of the compound suspension to the hydrogen peroxide solution is controlled so that the mass ratio of the nano silver to the hydrogen peroxide is 1:50-200, preferably 1: 50-100.
, it can be diluted to adjust the concentration of nano-silver in the disinfection matrix solution to 0.01-0.1%, preferably 0.01-0.05% by mass with deionized water.
Where colloidal silver ions of hydrogen peroxide are used, the colloidal silver ions do not exceed 0.1% by weight of hydrogen peroxide, the colloidal silver ion hydrogen peroxide solution may be formulated by mixing as in in the art or may be selected from commercially available products such as norfu disinfectant.
Alternatively, when the mixing is performed with a hydrogen peroxide solution, a proper amount of colloidal silver ions may also be added, the amount being 0.05 to 0.1 wt% by mass of hydrogen peroxide.
Wherein, the hydrogen peroxide solution is preferably of pharmaceutical grade, and the volume concentration can be 40-90%.
Step 3): preparing a bacteriostatic degradable surfactant solution:
dissolving a proper amount of biosurfactant in an ethanol mixed solvent added with a proper amount of cosolvent to obtain a biosurfactant solution with the weight percent of 5-10, and mixing and compounding the biosurfactant solution with Tween emulsifier and deionized water to obtain the bacteriostatic surfactant matrix liquid.
In this step, the biosurfactant is preferably a bacteriostatic degradable biosurfactant.
Wherein, the bacteriostatic degradable biosurfactant is selected from glycolipid biosurfactant, preferably mannosylerythritol lipid (such as MEL-A/MEL-B) or sophorolipid, and more preferably the composition of the two mixed in any proportion.
Wherein, the cosolvent is selected from dimethyl sulfoxide or ethyl acetate, and ethyl acetate is preferred when the cosolvent is used for sterilizing vegetables and fruits.
Wherein, the proportion of ethanol and cosolvent in the ethanol-cosolvent mixed solvent is 10: 1-5.
Preferably, the volume ratio is 10: 3-5.
Wherein the tween emulsifier is selected from tween 60 or tween 80, preferably tween 80; the mass ratio of the biosurfactant to the Tween is controlled to be 5-6: 1.
Further , the concentration of the matrix solution may be adjusted with deionized water so that the final mass fraction of biosurfactant in the matrix solution is 0.1-1 wt%, preferably 0.5-1 wt%.
Step 4): and adjusting the prepared disinfection matrix liquid and the bacteriostatic surfactant matrix liquid to proper concentrations, mixing, adding optional polyvinylpyrrolidone, and uniformly stirring to prepare the environment-friendly easily-cleaned bactericidal preservative composition.
Wherein the mass ratio of the diluted disinfection matrix liquid to the bacteriostatic surfactant matrix liquid is 1:0.5-1.5, preferably 1:0.5-1.
Wherein, the addition amount of the polyvinylpyrrolidone is preferably 0 to 0.05 percent by weight; when the polyvinyl pyrrolidone is used for film coating sterilization and fresh keeping, the addition amount of the polyvinyl pyrrolidone can be properly adjusted by those skilled in the art according to the required film forming time, for example, 0.05-0.5% by weight.
Wherein, polyvinylpyrrolidone iodine (PVP-I) can also be adopted to replace polyvinylpyrrolidone.
In a third aspect, the invention provides the use of the composition for sterilization and preservation.
The fresh-keeping comprises the sterilization and fresh-keeping of fruits and vegetables, in particular to the film coating sterilization and fresh-keeping treatment of fruits with skins.
The beneficial effects of the present invention include, but are not limited to, the following aspects.
1) The disinfection and sterilization composition of the supported nano silver-titanium dioxide and the antibacterial surfactant, provided by the invention, disperses silver nanoparticles among the mesoporous silicon dioxide and the titanium dioxide through adsorption, so that the silver nanoparticles are uniformly dispersed, direct contact with an object is avoided, and the problem that the effect of a common silver nano bactericide is not lasting enough is solved; the titanium dioxide is used as an inorganic bactericidal component with a strong effect and has a synergistic bactericidal effect.
2) The composite nano inorganic metal antibacterial agent is combined with the mesoporous carrier, the adhesive force of the nano silver is strong due to the ordered pore channel structure, the large and uniform pore diameter, the larger specific surface area and the pore volume of the carrier material, the free nano silver is greatly reduced, the dispersity is excellent, meanwhile, due to the addition of the nano titanium dioxide, the adhesive property of the nano silver particles is further improved in step , the composite nano inorganic metal antibacterial agent has a good slow release effect, is matched with a film forming component, has the advantages of stable antibacterial performance, long sterilization time, convenience in use and the like, and has no toxic or side effect on the environment.
3) The carrier material has huge surface area and abundant pore structures, so that the carrier material can well adsorb foreign bacteria, prevent the bacteria from directly contacting with objects, form a locally enhanced sterilization effect due to the enrichment of nano silver on the surface of the carrier, and simultaneously maintain the long-term effective metal ion concentration.
4) The nano silver and colloidal silver particles not only have the sterilization function, but also have the stabilizing effect on the hydrogen peroxide, effectively inhibit the decomposition of the hydrogen peroxide and improve the storage time of the hydrogen peroxide.
5) The active agent adopts bacteriostatic degradable biological surfactant, the raw materials have bacteriostatic property, have no toxicity or side effect due to chemical property, are safe even if used for preserving food, have no toxicity or stimulation to human bodies, can be quickly degraded by microorganisms in the nature, do not remain, and do not damage or pollute the environment, and the polyvinylpyrrolidone serving as the auxiliary agent is food additives with higher safety degree.
6) The sterilization, disinfection and preservation composition disclosed by the invention contains the surfactant with good film-forming property and the polyvinylpyrrolidone, so that the sterilization, disinfection and preservation composition is suitable for sterilization, coating and preservation of fruits; meanwhile, due to the existence of the surfactant, the effect of quick cleaning can be achieved without an external detergent.
7) The product of the invention is used for , can be used for disinfecting the surfaces of daily appliances by adjusting the concentration, can also be used for disinfecting hand sanitizer and cleaning solution, and can also be used for sterilizing, coating and refreshing fruits and vegetables, particularly fruits with skins by adjusting the addition amount of polyvinylpyrrolidone.
Detailed Description
The present invention is described in detail below with reference to specific examples, but the use and purpose of these exemplary embodiments are merely to exemplify the present invention, and do not set forth any limitation on the actual scope of the present invention in any form, and the scope of the present invention is not limited thereto.
Example 1
method for preparing environment-friendly and easy-to-clean type sterilization and preservation composition, comprising the following steps:
1) preparing a mesoporous silica-loaded nano silver-titanium dioxide compound suspension:
s1: adding 10-20nm nano silver particles into distilled water to prepare 1L of nano silver slurry with the mass fraction of 2%, adding 210g of mesoporous silica particles, stirring the mixed solution on a magnetic stirrer for 15min, then continuously performing ultrasonic oscillation on the mixed solution in an ultrasonic oscillator for 10min, and then standing and adsorbing the mixed solution for 30min to obtain a silica-loaded nano silver particle composite suspension;
s2: and adding 155g of nano titanium dioxide into the prepared nano silver particle composite suspension loaded by the silicon dioxide, heating to 60 ℃, rapidly stirring for 20min under magnetic stirring, and then placing on a shaking table at 100rpm for oscillation and adsorption for 60min to obtain the nano silver-titanium dioxide composite suspension loaded by the mesoporous silicon dioxide.
2) And mixing the prepared supported nano silver-titanium dioxide compound suspension and 4.05kg of 50% hydrogen peroxide solution by mass, and uniformly stirring to prepare the disinfection matrix solution.
, diluting part of the above disinfectant matrix solution with deionized water to obtain diluted disinfectant matrix solution with nano-silver concentration of 0.02 wt%, and collecting 1kg of the diluted disinfectant matrix solution.
3) Preparing bacteriostatic surfactant matrix liquid
S1: dissolving a composite biosurfactant composed of mannose erythritol ester (MEL-A) and sophorolipid in an equal mass ratio in an ethanol-ethyl acetate mixed solvent with the volume ratio of 10:3 to obtain a biosurfactant solution with the weight percent of 5;
s2: adding Tween 80 accounting for 20% of the mass of the surfactant into the biosurfactant solution, adding a proper amount of deionized water, and fully stirring and emulsifying to obtain a disinfection matrix solution; and (3) taking part of the disinfection matrix liquid to be diluted by deionized water until the mass concentration of the biosurfactant is 0.8 wt% for standby.
4) Mixing 1kg of the diluted disinfection matrix liquid obtained in the step 2) and 0.8kg of the diluted bacteriostatic surfactant matrix liquid obtained in the step 3), adding 1g of polyvinylpyrrolidone, and uniformly stirring to prepare the environment-friendly and easily-cleaned sterilization and preservation combined liquid.
Example 2
1) Preparing a mesoporous silica-loaded nano silver-titanium dioxide compound suspension:
s1: adding 20nm nano-silver particles into distilled water to prepare 100mL of nano-silver slurry with the mass fraction of 3%, adding 30g of mesoporous silica particles, stirring the mixed solution on a magnetic stirrer for 12min, then continuously performing ultrasonic oscillation in an ultrasonic oscillator for 15min, and then standing and adsorbing for 30min to obtain a silica-loaded nano-silver particle composite suspension;
s2: adding 15g of nano titanium dioxide into the prepared nano silver particle composite suspension loaded by the silicon dioxide, heating to 50 ℃, rapidly stirring for 20min under magnetic stirring, and then placing on a shaking table at 200rpm for oscillation and adsorption for 60min to obtain the nano silver-titanium dioxide composite suspension loaded by the mesoporous silicon dioxide.
2) And mixing the prepared supported nano silver-titanium dioxide compound suspension and 1.2kg of 50% hydrogen peroxide solution by mass, and uniformly stirring to prepare the disinfection matrix solution.
, diluting the disinfection substrate liquid with deionized water to 0.01% by mass concentration of nano-silver to obtain diluted disinfection substrate liquid for later use.
3) Preparing bacteriostatic surfactant matrix liquid
S1: dissolving sophorolipid biosurfactant in an ethanol-ethyl acetate mixed solvent with the volume ratio of 10:5 to obtain 5 wt% biosurfactant solution;
s2: adding Tween 60 accounting for 20% of the mass of the surfactant into the biosurfactant solution, adding a proper amount of deionized water, and fully stirring and emulsifying to obtain a disinfection matrix solution;
s3: and (3) taking part of the disinfection matrix liquid to be diluted by deionized water until the mass concentration of the biosurfactant is 0.6 wt% for standby.
4) Mixing 1kg of the diluted disinfection matrix liquid obtained in the step 2) and 0.5kg of the diluted bacteriostatic surfactant matrix liquid obtained in the step 3), adding 0.5g of polyvinylpyrrolidone, and uniformly stirring to prepare the environment-friendly and easily-cleaned sterilization and preservation combined liquid.
Comparative example 1
Comparative example 1 was obtained by following the same procedure as in example 2 except that the supported nano silver-titanium dioxide composite suspension was replaced with a suspension having the same nano silver concentration (without mesoporous silica and nano titanium dioxide), and the product was designated as D1.
Comparative example 2
Only the diluted disinfection matrix solution (nano-silver mass concentration of 0.01% and hydrogen peroxide concentration of 2%) obtained in step 2) of example 2 was contained, and the product was recorded as D2.
Comparative example 3
Comparative example 3 was obtained by adjusting the mass concentration of the surfactant to 0.5 wt% while only containing the bacteriostatic surfactant-based liquid prepared in the same manner as in step 3) of example 2, and the product was denoted as D3.
Effect example 1
Bactericidal test
The sterilization performance of each composition is compared through the diameter of the inhibition zone, and the specific method is as follows: making filter paper into a round piece with a diameter of about 5-6mm, placing the round piece into a culture dish, covering the round piece, performing high-pressure sterilization treatment at 121 ℃, drying the round piece, immersing the round piece into different bacteriostatic composition solutions for 2-3min, drying the round piece for later use, and soaking the round piece in distilled water to be used as a blank control; clamping each filter paper disc treated by the composition solution by using sterile tweezers, placing the filter paper disc in a check type culture medium coated with a saprophytic bacteria suspension (penicillium, aspergillus and yeast saprophytic bacteria separated from the surface of a rotten apple), placing 2-3 discs on each culture medium, covering a culture dish, placing the culture dish in a thermostat at 28-30 ℃, culturing for 36h, starting observation, selecting a uniform and completely sterile growth inhibition zone, measuring the average diameter of the inhibition zone by using a vernier caliper (at least taking the average value of three groups), and recording the result (taking more than 10mm as sensitivity); meanwhile, the antibacterial persistence is detected by continuously observing for 3-5 days. The results are shown in the following table.
TABLE 1 zone of inhibition diameter test
According to the test results, except for the distilled water control treatment group, each group has an obvious bacteriostatic circle, and the bacteriostatic action on various pythium pathogens is proved. The inhibition zone of the test group of example 1-2 was significantly increased compared to the control group, which demonstrated that there was a synergistic interaction between the components.
With the increase of the culture time to the 5 th day, the filter paper sheets of the blank control group gradually grow mildew spots, the inhibition zones of the groups of the comparative examples 1 to 3 are obviously reduced, the color of the culture medium is gradually deepened, while the inhibition zones of the examples 1 to 2 are only slightly reduced, the color change is light, and the results prove that the supported nano-silver composite preparation has an obvious antibacterial effect and a lasting slow-release effect.
Effect example 2
Testing of fruit and vegetable freshness retaining property
100 ripe fresh tomatoes with similar sizes and complete surfaces, namely eight to nine ripe fresh tomatoes with similar sizes, are selected for each group, the products of the embodiment 1 and the comparative examples 1-3 are respectively used for spray coating treatment (no treatment is carried out on a blank control group), then the groups are placed in a constant temperature box with relative humidity of 45% at 25 ℃ for 11 days, and the total weight loss rate of the tomatoes of each group along with the preservation time and the rotting rate (percentage of rotted fruits to the total fruits and retention percentage integral value) after the test are observed. The weight loss results are shown in the table below.
Table 2 tomato weight loss ratio test
After the test is finished, the decay rates of the groups of the examples 1, D1-D3 and the blank group are respectively as follows: 0%, 2%, 4%, 3%, and 14%.
Compared with the control group, the weight loss rate of the disinfection and preservation composition coating treatment group in the embodiment 1 is obviously reduced, the weight loss rate is slowly increased along with the prolonging of the storage period, the weight loss rate of the D2 treatment group is higher than that of other control groups, so that the water retention of the simple disinfection treatment is not as good as that of the coating preservation treatment containing a surfactant and polyvinylpyrrolidone, and the product of the embodiment 1 containing mesoporous silicon dioxide and titanium dioxide forms layers of modified atmosphere films on the surface of an object after the coating treatment, so that the cell respiration and the water transpiration are weakened, and the durability of the slow release effect and the sterilizing capability of the product are obviously better than those of the control group.
It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Further, it should also be understood that various alterations, modifications and/or variations can be made to the present invention by those skilled in the art after reading the technical content of the present invention, and all such equivalents fall within the protective scope defined by the claims of the present application.
Claims (9)
1, kinds of environment-friendly easy-to-clean type sterilization and preservation composition, which is characterized by at least comprising the following components:
1) and (2) component A: a mesoporous silica-supported nano silver-titanium dioxide composite and hydrogen peroxide;
2) and (B) component: bacteriostatic biosurfactant, organic solvent and emulsifier;
wherein the organic solvent comprises at least ethanol;
the emulsifier is selected from Tween emulsifiers;
3) auxiliary components including deionized water and suitable auxiliaries;
the auxiliary agent is selected from a film forming agent, a cosolvent, a dispersing agent or a stabilizing agent.
2. The composition of claim 1, wherein the bacteriostatic biosurfactant is selected from the group consisting of degradable glycolipid biosurfactants; the auxiliary agent is selected from polyvinylpyrrolidone.
3, A method for preparing the environment-friendly easy-to-clean type sterilization and preservation composition of claim 1, which is characterized by comprising the following steps:
1) preparing a silicon dioxide loaded nano silver particle compound suspension from nano silver slurry and mesoporous silica particles, adding a proper amount of nano titanium dioxide, vibrating and stirring to prepare a mesoporous silicon dioxide loaded nano silver-titanium dioxide compound suspension;
2) mixing the prepared supported nano silver-titanium dioxide compound suspension and a hydrogen peroxide solution or a hydrogen peroxide colloidal silver ion solution, and uniformly stirring to prepare a disinfection matrix solution;
3) dissolving a proper amount of biosurfactant in an ethanol mixed solvent added with a cosolvent to obtain a biosurfactant solution with the weight percent of 5-10, and mixing and compounding the biosurfactant solution with a Tween emulsifier and deionized water to obtain a bacteriostatic surfactant matrix liquid;
optionally, adjusting the concentration of the matrix solution with deionized water so that the final mass fraction of biosurfactant in the matrix solution is 0.1-1 wt%;
4) and (2) adjusting the prepared disinfection matrix liquid and the bacteriostatic surfactant matrix liquid to proper concentrations, mixing, optionally adding a proper amount of polyvinylpyrrolidone, and uniformly stirring, thereby preparing the environment-friendly easily-cleaned bactericidal preservative composition.
4. The preparation method according to claim 3, wherein the step (1) comprises the following steps:
s1: adding nano-silver particles into distilled water to prepare nano-silver slurry with the mass fraction of 1-5%, adding mesoporous silica particles with the mass of 5-20 times that of the nano-silver, stirring the mixed solution on a magnetic stirrer for 15-30min, then ultrasonically oscillating the mixed solution in an ultrasonic oscillator for 5-15min, and then standing and adsorbing the mixed solution for 30min to obtain a nano-silver particle composite suspension loaded by the mesoporous silica;
s2: adding nano titanium dioxide into the prepared silica-loaded nano silver particle composite suspension, magnetically and rapidly stirring for 15-25min at 50-60 ℃, and then oscillating and adsorbing for 30-60min by a 100-plus-200 rpm shaking table to obtain the mesoporous silica-loaded nano silver-titanium dioxide composite suspension.
5. The preparation method according to claim 4, wherein the nano titanium dioxide particles are added in an amount of 5 to 10 times the mass of the nano silver; the particle size of the nano silver particles is 10-100 nm.
6. The method according to claim 3, wherein the mass ratio of the nano-silver to the hydrogen peroxide in the step (2) is 1:50 to 200, preferably 1:50 to 100, and the concentration of the disinfectant base solution is adjusted to 0.01 to 0.1, preferably 0.01 to 0.05% by mass with deionized water in the step .
7. The process according to claim 3, wherein in step (3), the biosurfactant is selected from the group consisting of glycolipid biosurfactants, preferably mannosylerythritol lipids, sophorolipids, and mixtures thereof.
8. The production method according to claim 3 or 7, characterized in that:
the proportion of the ethanol to the cosolvent is 10: 1-5;
the cosolvent is selected from dimethyl sulfoxide or ethyl acetate;
the Tween emulsifier is selected from Tween 60 or Tween 80;
the mass ratio of the biosurfactant to the tween is 5-6: 1.
9. Use of the composition according to claims 1-2 or the composition obtained by the preparation method according to claims 3-7 as a disinfectant for disinfecting or preserving vegetables and fruits.
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