CN110729168B - Small mass spectrometer - Google Patents
Small mass spectrometer Download PDFInfo
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- CN110729168B CN110729168B CN201910990118.6A CN201910990118A CN110729168B CN 110729168 B CN110729168 B CN 110729168B CN 201910990118 A CN201910990118 A CN 201910990118A CN 110729168 B CN110729168 B CN 110729168B
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- tube
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0422—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for gaseous samples
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
Abstract
The invention provides a small-sized mass spectrometer, which comprises an ion probe, an interface (11) and a mass analyzer connected with the ion probe through the interface (11); the ion probe is characterized by comprising a first tube (12), a second tube (13), a sampling tube (14), a discharge plate (15) and an airflow adjusting plate (16); and the second tube (13) is concentrically arranged in the first tube (12), the sampling tube (14) is concentrically arranged in the second tube (13), the discharge plate (15) is fixed on the outer wall of the second tube (13), and the airflow adjusting plate (16) is arranged between the sampling tube (14) and the second tube (13). The miniature mass spectrometer has higher sensitivity because the loss of sample ions in the conveying process of the sampling tube is smaller.
Description
Technical Field
The invention relates to the technical field of substance detection, in particular to a small mass spectrometer.
Background
Mass spectrometers detect and analyze molecules of different molecular weights according to the difference in the charge-to-mass ratio (m/z) of ions. In a miniaturized mass spectrometer, the ions are usually obtained by a plasma generated by an ion probe near the sample and interacting with molecules on the surface of the sample to generate sample ions, which are transported along a sampling tube under the action of a gas flow to a mass analyzer for analysis and detection. However, the sample ions will contact the inner wall of the sampling tube during transport of the sampling tube, causing ion loss due to neutralization effects, thereby reducing the sensitivity of the mass spectrometer analysis.
Disclosure of Invention
In view of the above problems, the present invention provides a compact mass spectrometer having a high sensitivity due to a small loss of sample ions during transportation in a sampling tube.
The invention provides a small-sized mass spectrometer, which comprises an ion probe, an interface 11 and a mass analyzer connected with the ion probe through the interface 11; the ion probe comprises a first tube 12, a second tube 13, a sampling tube 14, a discharge plate 15 and an airflow adjusting plate 16; and the second tube 13 is concentrically placed in the first tube 12, the sampling tube 14 is concentrically placed in the second tube 13, the discharge plate 15 is fixed on the outer wall of the second tube 13 and the airflow adjusting plate 16 is disposed between the sampling tube 14 and the second tube 13.
The first tube 12 and the sampling tube 14 may be conductor tubes or insulating tubes with inner walls at least partially covered with conductors, and the second tube 13 is an insulating tube with outer walls partially covered with conductors.
The material of the airflow adjusting plate 16 is an insulating material.
Wherein, the air flow adjusting plate 16 comprises a first circular ring 161 fixed on the sampling pipe 14 and a second circular ring 162 fixed on the inner wall of the second pipe 13, and at least two circles of circular holes are concentrically arranged on the first circular ring 161 and the second circular ring 162.
Wherein the inner diameter of the first circular ring 161 is equal to the outer diameter of the sampling tube 14, and the outer diameter of the first circular ring 161 is equal to or smaller than the inner diameter of the second tube 13; and the inner diameter of the second circular ring 162 is greater than or equal to the outer diameter of the sampling tube 14 and the outer diameter of the second circular ring 162 is equal to the inner diameter of the second tube 13.
Wherein no flow passes between the first annulus 161 and the outer wall of the sample tube 14 and no flow passes between the second annulus 162 and the inner wall of the second tube 13.
Wherein, the first circular ring 161 and the second circular ring 162 have N circles of circular holes, and each circle has M circular holes; the center of the mth round hole on the nth circle of the first circular ring 161 and the center of the mth round hole on the (n + 1) th circle of the first circular ring 161 are on the same radius; the distance from the center of each round hole on the nth circle of the first ring 161 to the center of the first ring 161 is equal, and is equal to the distance from the center of each round hole on the nth circle of the second ring 162 to the center of the second ring 162.
The circular hole position setting on the second circular ring 162 should meet the requirement that when the right of the mth circular hole of the nth circle of the first circular ring 161 is tangent to the left of the mth circular hole of the nth circle of the second circular ring 162, the left of the mth circular hole of the (n + 1) th circle of the first circular ring 161 is tangent to the right of the mth circular hole of the (n + 1) th circle of the second circular ring 162.
Drawings
FIG. 1 is a schematic diagram of a miniature mass spectrometer of the present invention.
FIG. 2 is a schematic view of a first ring of the present invention;
FIG. 3 is a schematic view of a second ring of the present invention;
fig. 4 is a schematic view of an air flow regulating plate according to the present invention.
Detailed Description
Embodiments of the present application will be described in detail by examples, so that how to apply technical means to solve technical problems and achieve technical effects of the present application can be fully understood and implemented.
FIG. 1 is a schematic diagram of a miniature mass spectrometer of an embodiment of the invention. The miniature mass spectrometer comprises an ion probe, an interface 11 and a mass analyser, not shown, connected to the ion probe via the interface 11. The ion probe comprises a first tube 12, a second tube 13, a sampling tube 14, a discharge plate 15 and an airflow adjusting plate 16. The second tube 13 is concentrically placed in the first tube 12, the sampling tube 14 is concentrically placed in the second tube 13, the discharge plate 15 is fixed to the outer wall of the second tube 13, and the airflow adjusting plate 16 is disposed between the sampling tube 14 and the second tube 13. The first tube 12 may be a conductor tube or an insulating tube with an inner wall at least partially covered with a conductor, the second tube 13 is an insulating tube with an outer wall partially covered with a conductor, and the airflow adjusting plate 16 is made of an insulating material. A voltage of a voltage source (not shown) is applied to the discharge plate 15 via the first tube 12 or a conductor on the inner wall of the first tube 12 and a conductor on the outer wall of the second circular tube 13, thereby ionizing a gas (for example, air) passing between the first tube 12 and the second tube 13. The discharge plate 15 includes a circular ring and a plurality of discharge tips extending outward along a radius of the circular ring at an outer diameter of the circular ring. From the viewpoint of complete ionization of the gas, the number of discharge tips is preferably 16, 32.
Fig. 4 is a schematic view of a gas flow regulating plate of a miniature mass spectrometer of the present invention. The air flow adjusting plate 16 includes a first circular ring 161 and a second circular ring 162, and at least two circular holes are concentrically disposed on both the first circular ring 161 and the second circular ring 162. As shown in fig. 2 and 3, wherein fig. 2 is a schematic view of the first ring 161, and fig. 3 is a schematic view of the second ring 162. The inner diameter of the first circular ring 161 is equal to the outer diameter of the sampling tube 14, and the outer diameter of the first circular ring 161 is equal to or smaller than the inner diameter of the second tube 13. The first ring 161 is secured to the sampling tube 14 and no air flow passes between the first ring 161 and the outer wall of the sampling tube 14. The inner diameter of the second ring 162 is greater than or equal to the outer diameter of the sampling tube 14 and the outer diameter of the second ring 162 is equal to the inner diameter of the second tube 13. The second ring 162 is fixed to the inner wall of the second pipe 13 (for example, screws passing through the wall of the second pipe 13 may be used), and no air flow passes between the second ring 162 and the inner wall of the second pipe 13. The sampling tube 14, the first ring 161, the second ring 162, the second tube 13, and the first tube 12 are concentrically disposed.
Assume that the first ring 161 has N circles of circular holes, each circle having M circular holes. The second ring 162 also has N circles of circular holes, each circle also having M circular holes. The center of the mth circular hole on the nth turn of the first circular ring 161 and the center of the mth circular hole on the (n + 1) th turn of the first circular ring 161 are on the same radius, as shown in fig. 3. The distance from the center of each circular hole on the nth turn of the first circular ring 161 to the center of the first circular ring 161 is equal and equal to the distance from the center of each circular hole on the nth turn of the second circular ring 162 to the center of the second circular ring 162, as shown in fig. 4. Wherein the dotted lines represent the first circular ring 161 and the circular hole thereon, and the solid lines represent the second circular ring 162 and the circular hole thereon. The circular hole position setting on the second circular ring 162 should meet the requirement that when the right of the mth circular hole of the nth circle of the first circular ring 161 is tangent to the left of the mth circular hole of the nth circle of the second circular ring 162, the left of the mth circular hole of the (n + 1) th circle of the first circular ring 161 is tangent to the right of the mth circular hole of the (n + 1) th circle of the second circular ring 162.
In operation of the ion probe, gas (e.g. air) transported between the first tube 12 and the second tube 13 is ionized by the discharge plate 15 to form a plasma, which is transported by the gas flow to the surface of the sample 17 to interact with molecules on the surface of the sample 17 to generate sample ions, which are transported along the sampling tube 14 by the gas flow to a mass analyzer, not shown, to be analyzed and detected; when the circular holes of the first circular ring 161 and the second circular ring 162 of the airflow adjusting plate 16 are partially overlapped, the gas (e.g. air) transmitted between the second tube 13 and the sampling tube 14 is transmitted along the inner wall of the sampling tube 14 through the airflow adjusting plate, and a gas sheath layer is provided between the sample ions and the inner wall of the sampling tube 14, and the gas sheath layer has an effect of inhibiting the diffusion or migration of the sample ions toward the inner wall of the sampling tube 14, so that more sample ions are not in contact with the inner wall of the sampling tube 14 before reaching the end of the sampling tube 14, thereby increasing the number of ions reaching the mass analyzer (not shown) through the interface 11 at the end of the sampling tube 14, and further improving the sensitivity of sample ion detection.
To facilitate transport of gas transmitted between the second tube 13 and the sampling tube 14 along the inner wall of the sampling tube 14, the end of the sampling tube 14 near the sample 17 is farther from the end of the second tube 13 near the sample 17, and the wall of the sampling tube 14 near the end of the sample is rounded.
Because the round hole position on the second ring 162 is set, when the right of the mth round hole of the nth ring of the first ring 161 is tangent to the left of the mth round hole of the nth ring 162 of the second ring 162, the left of the mth round hole of the (n + 1) th ring of the first ring 161 is tangent to the right of the mth round hole of the (n + 1) th ring of the second ring 162. Thus, after the circular holes in the n-th ring of the first circular ring 161 and the circular holes in the n-th ring of the second circular ring 162 are partially overlapped, completely overlapped, partially overlapped and completely non-overlapped by rotating the sampling tube 14 or the second tube 13, the circular holes in the n + 1-th ring of the first circular ring 161 and the circular holes in the n + 1-th ring of the second circular ring 162 are partially overlapped, completely overlapped, partially overlapped and completely non-overlapped. In this way, not only can the flow rate of the air flow passing through the air flow adjustment plate 16 be changed, but also the position of the air flow passing through the air flow adjustment plate 16 can be changed, thereby maximizing the inhibition effect on the diffusion or migration of analyte ions, and finally minimizing the loss of analyte ions and maximizing the sensitivity of analyte ion detection.
There are many other possible embodiments of the present invention, which are not listed here, and the embodiments claimed in the claims of the present invention can be implemented.
The details not described in the specification of the present application belong to the common general knowledge of those skilled in the art.
Claims (7)
1. A miniature mass spectrometer comprising an ion probe, an interface (11) and a mass analyser connected to the ion probe via the interface (11); the ion probe is characterized by comprising a first tube (12), a second tube (13), a sampling tube (14), a discharge plate (15) and an airflow adjusting plate (16); the second tube (13) is concentrically arranged in the first tube (12), the sampling tube (14) is concentrically arranged in the second tube (13), the discharge plate (15) is fixed on the outer wall of the second tube (13), and the airflow adjusting plate (16) is arranged between the sampling tube (14) and the second tube (13); and the air flow adjusting plate (16) comprises a first circular ring (161) and a second circular ring (162), and circular hole parts on the first circular ring (161) and the second circular ring (162) of the air flow adjusting plate (16) are overlapped by rotating the sampling pipe (14) or the second pipe (13).
2. The mass spectrometer according to claim 1, wherein the first tube (12) and the sampling tube (14) are conductive tubes or insulating tubes having an inner wall at least partially covered with a conductor, the second tube (13) is an insulating tube having an outer wall partially covered with a conductor, and the gas flow regulating plate (16) is made of an insulating material.
3. The compact mass spectrometer as claimed in claim 2, characterised in that the gas flow regulating plate (16) comprises a first ring (161) fixed to the sampling tube (14) and a second ring (162) fixed to the inner wall of the second tube (13), and in that at least two circular holes are concentrically arranged in both the first ring (161) and the second ring (162).
4. A miniature mass spectrometer according to claim 3, wherein the inner diameter of the first circular ring (161) is equal to the outer diameter of the sampling tube (14), the outer diameter of the first circular ring (161) being equal to or less than the inner diameter of the second tube (13); and the inner diameter of the second circular ring (162) is larger than or equal to the outer diameter of the sampling pipe (14), and the outer diameter of the second circular ring (162) is equal to the inner diameter of the second pipe (13).
5. A miniature mass spectrometer according to claim 4 wherein no flow passes between the first annulus (161) and the outer wall of the sample tube (14) and no flow passes between the second annulus (162) and the inner wall of the second tube (13).
6. A miniature mass spectrometer as claimed in claim 5, wherein the first ring (161) and the second ring (162) each have N circles of circular apertures and each circle has M circular apertures; the center of the mth round hole on the nth circle of the first circular ring (161) and the center of the mth round hole on the (n + 1) th circle of the first circular ring (161) are on the same radius; the distance from the center of each round hole on the nth circle of the first ring (161) to the center of the first ring (161) is equal and equal to the distance from the center of each round hole on the nth circle of the second ring (162) to the center of the second ring (162).
7. The miniature mass spectrometer of claim 6, wherein the circular hole position on the second circular ring (162) is such that when the right edge of the mth circular hole of the nth circle of the first circular ring (161) is tangent to the left edge of the mth circular hole of the nth circle of the second circular ring (162), the left edge of the mth circular hole of the (n + 1) th circle of the first circular ring (161) is tangent to the right edge of the mth circular hole of the (n + 1) th circle of the second circular ring (162).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910990118.6A CN110729168B (en) | 2019-10-17 | 2019-10-17 | Small mass spectrometer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910990118.6A CN110729168B (en) | 2019-10-17 | 2019-10-17 | Small mass spectrometer |
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| Publication Number | Publication Date |
|---|---|
| CN110729168A CN110729168A (en) | 2020-01-24 |
| CN110729168B true CN110729168B (en) | 2022-04-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910990118.6A Active CN110729168B (en) | 2019-10-17 | 2019-10-17 | Small mass spectrometer |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103038857A (en) * | 2010-05-07 | 2013-04-10 | Ut-巴特勒有限责任公司 | System and method for extracting a sample from a surface |
| CN105531577A (en) * | 2013-07-24 | 2016-04-27 | 蒙特利尔史密斯安检仪公司 | In situ chemical transformation and ionization of inorganic perchlorates on surfaces |
| CN105874561A (en) * | 2013-11-15 | 2016-08-17 | 蒙特利尔史密斯安检仪公司 | Concentric APCI surface ionization ion source, ion guide, and method of use |
| CN107532975A (en) * | 2015-04-09 | 2018-01-02 | Ut-巴特勒有限公司 | Capture probe |
| CN109643636A (en) * | 2016-07-29 | 2019-04-16 | 史密斯探测公司 | Low temperature plasma probe with auxiliary heating gas jet flow |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006056929B4 (en) * | 2006-12-04 | 2010-09-02 | Bruker Daltonik Gmbh | Mass spectrometry with laser ablation |
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2019
- 2019-10-17 CN CN201910990118.6A patent/CN110729168B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103038857A (en) * | 2010-05-07 | 2013-04-10 | Ut-巴特勒有限责任公司 | System and method for extracting a sample from a surface |
| CN105531577A (en) * | 2013-07-24 | 2016-04-27 | 蒙特利尔史密斯安检仪公司 | In situ chemical transformation and ionization of inorganic perchlorates on surfaces |
| CN105874561A (en) * | 2013-11-15 | 2016-08-17 | 蒙特利尔史密斯安检仪公司 | Concentric APCI surface ionization ion source, ion guide, and method of use |
| CN107532975A (en) * | 2015-04-09 | 2018-01-02 | Ut-巴特勒有限公司 | Capture probe |
| CN109643636A (en) * | 2016-07-29 | 2019-04-16 | 史密斯探测公司 | Low temperature plasma probe with auxiliary heating gas jet flow |
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| CN110729168A (en) | 2020-01-24 |
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Effective date of registration: 20220402 Address after: 210000 east of floor 5, building 3, intelligent manufacturing Industrial Park (Zhicheng Park), No. 6, Zhida Road, Jiangbei new area, Nanjing, Jiangsu Province Applicant after: Nanjing Pinsheng Medical Technology Co.,Ltd. Address before: 310030 room 2603, building 8, No. 2, Xiyuan 8th Road, Sandun Town, Xihu District, Hangzhou City, Zhejiang Province Applicant before: HANGZHOU ZHUILIE TECHNOLOGY Co.,Ltd. |
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