CN110729024A - 一种基于拓扑结构相似性的蛋白质结构模型质量评估方法 - Google Patents
一种基于拓扑结构相似性的蛋白质结构模型质量评估方法 Download PDFInfo
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- CN110729024A CN110729024A CN201910793342.6A CN201910793342A CN110729024A CN 110729024 A CN110729024 A CN 110729024A CN 201910793342 A CN201910793342 A CN 201910793342A CN 110729024 A CN110729024 A CN 110729024A
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- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 90
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 90
- 238000000034 method Methods 0.000 title abstract description 18
- 238000013441 quality evaluation Methods 0.000 title abstract description 11
- 150000001413 amino acids Chemical class 0.000 claims abstract description 23
- 239000011159 matrix material Substances 0.000 claims abstract description 23
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 5
- 238000001303 quality assessment method Methods 0.000 claims description 3
- 238000011156 evaluation Methods 0.000 abstract description 8
- 239000013078 crystal Substances 0.000 description 4
- 238000000455 protein structure prediction Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 3
- 230000012846 protein folding Effects 0.000 description 3
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000329 molecular dynamics simulation Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 238000004422 calculation algorithm Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000004883 computer application Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/20—Protein or domain folding
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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Cited By (1)
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CN113223631A (zh) * | 2021-05-06 | 2021-08-06 | 吉林大学 | 一种晶体结构解析方法及系统 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107622182A (zh) * | 2017-08-04 | 2018-01-23 | 中南大学 | 蛋白质局部结构特征的预测方法及系统 |
WO2019040871A1 (en) * | 2017-08-24 | 2019-02-28 | Miller Julian | DEVICE FOR ENCODING AND STORING INFORMATION USING ARTIFICIALLY EXPANDED ALPHABETS OF NUCLEIC ACIDS AND OTHER ANALOGOUS POLYMERS |
CN109448784A (zh) * | 2018-08-29 | 2019-03-08 | 浙江工业大学 | 一种基于二面角信息辅助能量函数选择的蛋白质结构预测方法 |
US20190204339A1 (en) * | 2006-02-13 | 2019-07-04 | Washington University | Methods of polypeptide identification, and compositions therefor |
CN110120244A (zh) * | 2019-03-28 | 2019-08-13 | 浙江工业大学 | 一种基于接触图的蛋白质结构比对方法 |
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- 2019-08-27 CN CN201910793342.6A patent/CN110729024B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20190204339A1 (en) * | 2006-02-13 | 2019-07-04 | Washington University | Methods of polypeptide identification, and compositions therefor |
CN107622182A (zh) * | 2017-08-04 | 2018-01-23 | 中南大学 | 蛋白质局部结构特征的预测方法及系统 |
WO2019040871A1 (en) * | 2017-08-24 | 2019-02-28 | Miller Julian | DEVICE FOR ENCODING AND STORING INFORMATION USING ARTIFICIALLY EXPANDED ALPHABETS OF NUCLEIC ACIDS AND OTHER ANALOGOUS POLYMERS |
CN109448784A (zh) * | 2018-08-29 | 2019-03-08 | 浙江工业大学 | 一种基于二面角信息辅助能量函数选择的蛋白质结构预测方法 |
CN110120244A (zh) * | 2019-03-28 | 2019-08-13 | 浙江工业大学 | 一种基于接触图的蛋白质结构比对方法 |
Non-Patent Citations (2)
Title |
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JOHN L: ""A new method to improve network topological similarity search: applied to fold recognition"", 《BIOINFORMATICS》 * |
李书蔚: ""连续模型上的蛋白质分子场拓扑骨架的提取"", 《杭州电子科技大学学报》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113223631A (zh) * | 2021-05-06 | 2021-08-06 | 吉林大学 | 一种晶体结构解析方法及系统 |
CN113223631B (zh) * | 2021-05-06 | 2024-05-24 | 吉林大学 | 一种晶体结构解析方法及系统 |
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