CN110702761B - Miniature assembled biosensor structure - Google Patents
Miniature assembled biosensor structure Download PDFInfo
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- CN110702761B CN110702761B CN201910984743.XA CN201910984743A CN110702761B CN 110702761 B CN110702761 B CN 110702761B CN 201910984743 A CN201910984743 A CN 201910984743A CN 110702761 B CN110702761 B CN 110702761B
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Abstract
The invention provides a miniature assembled biosensor structure, which comprises a shell and a flexible circuit board, wherein the flexible circuit board is provided with a working electrode and a counter electrode; the flexible circuit board is clamped in the shell, the flexible circuit board is bent, the working electrode and the counter electrode are respectively located on two opposite surfaces of the bent inner portion of the flexible circuit board, the top surfaces of the working electrode and the counter electrode are oppositely arranged, and a micro-channel is formed between the opposite surfaces of the working electrode and the counter electrode. The working electrode and the counter electrode are connected by adopting a flexible bending structure, the working electrode WE and the counter electrode CE/reference electrode RE are separated, and batch processing can be realized respectively; meanwhile, when the working electrode is coated with enzyme and fixed with enzyme, because the working electrode WE is far away from other electrodes, the fine operation can be conveniently carried out; the production efficiency and the design precision are improved.
Description
Technical Field
The invention relates to the technical field of biochemical parameter acquisition, in particular to a miniature assembled biosensor structure.
Background
Due to the requirement of the working principle, the working electrode and the counter electrode of the biosensor need to be arranged at positions relatively close to each other. In the prior art, in the production process, the process is complex and the manufacturing difficulty is high due to the influence of large material difference between a working electrode and a counter electrode; the manufacturing process requires a large distance between the working electrode and the counter electrode; the contradiction between the manufacturing process and the structural principle limits the development of biosensors.
Disclosure of Invention
In view of the above, the present invention provides a micro-assembly biosensor structure, in which the working electrode and the counter electrode are far apart and are close to each other only after assembly.
A miniature assembled biosensor structure comprises a shell and a flexible circuit board, wherein a working electrode and a counter electrode are arranged on the flexible circuit board;
the flexible circuit board is clamped in the shell, the flexible circuit board is bent, the working electrode and the counter electrode are respectively located on two opposite sides of the bent inner portion of the flexible circuit board, the working electrode and the counter electrode are respectively located on the same side of the flexible circuit board before bending, the top surfaces of the working electrode and the counter electrode are oppositely arranged, and a micro channel is formed between the opposite surfaces of the working electrode and the counter electrode.
Preferably, the working electrode and the counter electrode have reaction membrane surfaces on the top and surface thereof.
Preferably, an upper side clamping groove and a lower side clamping groove are formed in the shell;
the upper side clamping groove is divided into a left side upper clamping groove and a right side upper clamping groove, and a gap is reserved between the left side upper clamping groove and the right side upper clamping groove;
the lower side clamping groove is divided into a left side lower clamping groove and a right side lower clamping groove, and a gap is reserved between the left side lower clamping groove and the right side lower clamping groove;
the working electrode and the counter electrode are arranged to protrude out of the surface of the flexible circuit board;
the working electrode is positioned in the middle of the flexible circuit board in the width direction, and the edges of the flexible circuit board on two sides of the working electrode are respectively clamped into the left upper clamping groove and the right upper clamping groove;
the counter electrode is located in the middle of the flexible circuit board in the width direction, and the edges of the flexible circuit board on the two sides of the counter electrode are clamped into the left lower clamping groove and the right lower clamping groove respectively.
The upper surface and the lower surface of the micro-channel are a working electrode and a counter electrode; the inner side wall of the shell forms a lateral dam of the micro-channel.
Preferably, the rear end of the shell extends out of the supporting arm, the bending part of the flexible circuit board is attached to the tail end of the supporting arm, and two surfaces of the inner side of the bending part of the flexible circuit board are respectively attached to the upper wall surface and the lower wall surface of the supporting arm.
Preferably, the supporting arm extends backwards from the position between the upper clamping groove and the lower clamping groove of the inner side wall of the shell;
the supporting arm is provided with a clamping notch, the flexible circuit board is provided with a signal processing module, and the signal processing module is clamped into the clamping notch.
Preferably, a branch flow channel of the micro flow channel is formed between two side walls of the working electrode and the inner side wall of the shell.
Preferably, one working electrode and one counter electrode constitute one sensor unit;
the number of the sensor units is more than two, and a liquid accommodating micro-groove is formed between the two sensor units.
Preferably, the side wall of the housing is provided with a via hole, and the via hole is located at the outlet of the micro flow channel.
Preferably, the micro flow channel is provided with an inlet, and a filtering structure is arranged at the inlet; the inside of the micro flow channel is provided with a flow guide material.
Preferably, the wall body between the upper clamping groove and the lower clamping groove extends out of the support filter screen towards the middle part, a transition chamfer is arranged at the connecting part of the support filter screen and the wall body, and unfilled corners matched with the transition chamfer are arranged on the working electrode and the counter electrode; the working electrode and the counter electrode are respectively positioned on two sides of the support filter screen, and the distance between the top surfaces of the working electrode and the counter electrode is 50-300 mu m.
The distance between the top surfaces of the working electrode and the counter electrode and the surface of the supporting filter screen is 10-100 mu m.
The invention also provides another miniature assembled biosensor structure.
A miniature assembled biosensor structure comprises a shell and a rigid-flex board, wherein a working electrode and a counter electrode are arranged on the rigid-flex board;
the flexible-rigid combined board is bent, the flexible-rigid combined board is clamped in the shell, the bending part of the flexible-rigid combined board is a flexible circuit board, the working electrode and the counter electrode are respectively positioned on two opposite sides of the bent inner part of the flexible-rigid combined board, the working electrode and the counter electrode are oppositely arranged, and a micro channel is formed between the working electrode and the counter electrode.
Preferably, the two ends of the rigid-flex board are respectively provided with a first rigid circuit board and a second rigid circuit board, and the working electrode is positioned on the first rigid circuit board; the counter electrode is positioned on the second hard circuit board.
The working electrode and the counter electrode are connected by adopting a flexible bending structure, the working electrode WE and the counter electrode CE/reference electrode RE are separated, and batch processing can be realized respectively; meanwhile, when the working electrode is coated with enzyme and fixed with enzyme, the working electrode WE is far away from other electrodes, so that batch operation can be conveniently carried out; the electrodes can be directly made on the flexible material, and can also be rigid discrete electrodes, such as ceramic substrate electrodes, silicon substrate electrodes and the like, and are fixed on the FPC by welding or bonding methods, and welding spots and the like need insulation treatment; after the electrode is made, modifying an enzyme membrane, an ionic membrane and the like on the working electrode; after the reaction layer is made, a high-temperature process cannot be carried out.
The invention has the beneficial effects that: a miniature assembled biosensor structure comprises a shell and a flexible circuit board, wherein a working electrode and a counter electrode are arranged on the flexible circuit board; the flexible circuit board is clamped in the shell, the flexible circuit board is bent, the working electrode and the counter electrode are respectively located on two opposite surfaces of the bent inner portion of the flexible circuit board, the top surfaces of the working electrode and the counter electrode are oppositely arranged, and a micro-channel is formed between the opposite surfaces of the working electrode and the counter electrode. The working electrode and the counter electrode are connected by adopting a flexible bending structure, the working electrode WE and the counter electrode CE/reference electrode RE are separated, and batch processing can be realized respectively; meanwhile, when the working electrode is coated with enzyme and fixed with enzyme, because the working electrode WE is far away from other electrodes, the fine operation can be conveniently carried out; the production efficiency and the design precision are improved.
Drawings
The multifunctional adapter housing of the present invention is further described below with reference to the accompanying drawings.
FIG. 1 is a cross-sectional view of a micro-fabricated biosensor structure according to the present invention.
FIG. 2 is a schematic view of a micro-assembly biosensor structure according to the present invention.
FIG. 3 is an exploded view of a perspective view of a microfabricated biosensor structure of the invention.
FIG. 4 is a schematic diagram of the housing and the support arm of a micro-assembly biosensor structure according to the present invention.
FIG. 5 is a cross-sectional view of a housing and support arm of a microfabricated biosensor structure of the present invention.
FIG. 6 is a schematic structural diagram of a rigid-flex board of a micro-assembly biosensor structure according to the present invention.
FIG. 7 is a schematic view of a part of the structure of the support screen of a micro-assembly biosensor structure according to the present invention.
In the figure:
1-a shell; 11-upper side card slot; 111-left upper card slot; 112-card slot on right side; 12-lower side card slot; 121-left lower card slot; 122-right lower card slot; 13-a via hole; 2-a flexible circuit board; 21-a working electrode; 22-a counter electrode; 23-a signal processing module; 3-micro flow channel; 31-branch flow channel; 4-liquid-containing micro-tanks; 5-a support arm; 51-a snap notch; 6-rigid-flex board; 61-a first rigid wiring board; 62-a second rigid wiring board; 63-flexible circuit board; 8-supporting the filter screen; 9-transition corner cut.
Detailed Description
The structure of a micro-assembly biosensor according to the present invention will be further described with reference to the accompanying drawings 1 to 7.
A miniature assembled biosensor structure comprises a shell 1 and a flexible circuit board 2, wherein a working electrode 21 and a counter electrode 22 are arranged on the flexible circuit board 2;
the flexible circuit board 2 is clamped in the shell 1, the flexible circuit board 2 is bent, before bending, the working electrode 21 and the counter electrode 22 are located on the same surface of the flexible circuit board 2, the working electrode 21 and the counter electrode 22 are respectively located on two opposite surfaces of the bent inner portion of the flexible circuit board 2, the top surfaces of the working electrode 21 and the counter electrode 22 are oppositely arranged, and a micro-channel 3 is formed between the opposite surfaces of the working electrode 21 and the counter electrode 22.
In this embodiment, the reaction films of the working electrode 21 and the counter electrode 22 are on the top surface.
The side surfaces of the working electrode 21 and the counter electrode 22 may be provided with a reaction film.
In this embodiment, an upper card slot 11 and a lower card slot 12 are arranged inside the housing 1;
the upper card slot 11 is divided into a left upper card slot 111 and a right upper card slot 112, and a space is left between the left upper card slot 111 and the right upper card slot 112;
the lower card slot 12 is divided into a left lower card slot 121 and a right lower card slot 122, and a space between the left lower card slot 121 and the right lower card slot 122 is left;
the working electrode 21 and the counter electrode 22 are arranged to protrude from the surface of the flexible circuit board 2;
the working electrode 21 is located in the middle of the flexible circuit board 2 in the width direction, and the edges of the flexible circuit board 2 on both sides of the working electrode 21 are respectively clamped into the left upper clamping groove 111 and the right upper clamping groove 112;
the counter electrode 22 is located in the middle of the flexible circuit board 2 in the width direction, and the edges of the flexible circuit board 2 on both sides of the counter electrode 22 are respectively clamped into the left lower clamping groove 121 and the right lower clamping groove 122.
In this embodiment, the rear end of the housing 1 extends out of the support arm 5, the bent portion of the flexible circuit board 2 is attached to the tail end of the support arm 5, and two surfaces of the inner side of the bent portion of the flexible circuit board 2 are respectively attached to the upper wall surface and the lower wall surface of the support arm 5.
In this embodiment, the supporting arm 5 extends backwards from between the upper clamping groove 11 and the lower clamping groove 12 on the inner side wall of the shell 1;
the support arm 5 is provided with a clamping notch 51, the flexible circuit board 2 is provided with a signal processing module 23, and the signal processing module 23 is clamped into the clamping notch 51. The signal processing module 23 includes a chip, a processing circuit, and the like
In the present embodiment, the support arm 5 and the housing 1 are integrally provided.
In the present embodiment, a branch flow channel 31 of the microchannel 3 is formed between both side walls of the working electrode 21 and the inner wall of the housing 1.
In the present embodiment, one working electrode 21 and one counter electrode 22 constitute one sensor unit;
the number of the sensor units is more than two, and a liquid containing micro-groove 4 is formed between the two sensor units.
In this embodiment, the working electrode 21 and the counter electrode 22 of each sensor unit comprise a plurality of layers, and the layers of the working electrode 21 and the counter electrode 22 correspond to each other to form a microelectrode unit in different depths of the liquid-containing micro-groove 4; the reaction liquid reacts with different microelectrode units from the side, so that the reaction precision and sensitivity are improved.
The different layers of working electrode 21 and counter electrode 22 may be the same electrode, with the liquid at different heights and the slight difference in concentration sensed.
Different layers of the working electrode 21 and the counter electrode 22 can be different electrodes, so that different parameters at the same position can be monitored in a centralized and close-range manner, and the consistency of the reaction solution is ensured;
in this embodiment, the sidewall of the housing 1 is provided with a through hole 13, the through hole 13 is located at the outlet of the micro flow channel 3, the outlet is a liquid discharge port, and the liquid discharge port can be designed into a standard structure, such as a negative pressure device.
In this embodiment, the microchannel 3 is provided with an inlet at the front end of the housing 1, and a filter structure is provided at the inlet. The inside of the micro flow channel 3 is provided with a flow guide material, and the flow guide material can be a water absorption material, a fiber material and the like to be used as a flow channel driving force.
In this embodiment, the wall body between the upper side clamping groove 11 and the lower side clamping groove 12 extends out of the support filter screen 8 towards the middle part, the connecting part of the support filter screen 8 and the wall body is provided with a transition chamfer 9, and the working electrode 21 and the counter electrode 22 are provided with unfilled corners matched with the transition chamfer 9; the working electrode 21 and the counter electrode 22 are respectively positioned at two sides of the support filter screen 8, and the distance between the top surfaces of the working electrode 21 and the counter electrode 22 is 50-300 mu m.
The distance between the top surfaces of the working electrode 21 and the counter electrode 22 and the surface of the support screen 8 is 10 to 100 μm.
The invention also provides another miniature assembled biosensor structure.
Compared with the structure of the miniature assembled biosensor, the structure of the miniature assembled biosensor is characterized in that the flexible circuit board 2 is replaced by the rigid-flexible printed circuit board 6, and the structures of different parts of the flexible printed circuit board 6 can be flexibly arranged, so that the rigid-flexible printed circuit board 6 can meet the folding requirements and can also meet the clamping requirements of all parts.
A miniature assembled biosensor structure comprises a shell 1 and a rigid-flex board 6, wherein a working electrode 21 and a counter electrode 22 are arranged on the rigid-flex board 6;
the rigid-flex board 6 is bent, the rigid-flex board 6 is clamped in the shell 1, the bent part of the rigid-flex board 6 is a flexible circuit board 63, the working electrode 21 and the counter electrode 22 are respectively positioned on two opposite sides of the bent inner part of the rigid-flex board 6, the working electrode 21 and the counter electrode 22 are oppositely arranged, and a micro-channel 3 is formed between the working electrode 21 and the counter electrode 22.
In this embodiment, the two ends of the rigid-flex board 6 are respectively provided with a first rigid circuit board 61 and a second rigid circuit board 62, and the working electrode 21 is located on the first rigid circuit board 61; the counter electrode 22 is located on the second rigid wiring board 62.
In this embodiment, other portions are provided with reference to the embodiment corresponding to the flexible circuit board 2.
An upper clamping groove 11 and a lower clamping groove 12 are arranged in the shell 1;
the upper card slot 11 is divided into a left upper card slot 111 and a right upper card slot 112, and a space is left between the left upper card slot 111 and the right upper card slot 112;
the lower card slot 12 is divided into a left lower card slot 121 and a right lower card slot 122, and a space between the left lower card slot 121 and the right lower card slot 122 is left;
the working electrode 21 and the counter electrode 22 are arranged to protrude out of the surface of the rigid-flex circuit board 6;
two opposite surfaces of the bent interior of the rigid-flex board 6 are respectively clamped into the left upper clamping groove 111 and the right upper clamping groove 112;
the other surfaces of the two opposite surfaces of the bent interior of the rigid-flex board 6 are respectively clamped into the left lower clamping groove 121 and the right lower clamping groove 122. The foregoing is only a preferred embodiment of this invention and it should be noted that modifications can be made by those skilled in the art without departing from the principle of the invention and these modifications should also be considered as the protection scope of the invention.
Claims (8)
1. A miniature assembled biosensor structure comprises a shell (1) and is characterized by further comprising a flexible circuit board (2), wherein a working electrode (21) and a counter electrode (22) are arranged on the flexible circuit board (2);
the flexible circuit board (2) is clamped in the shell (1), the flexible circuit board (2) is bent, the working electrode (21) and the counter electrode (22) are respectively positioned on two opposite surfaces of the bent inner part of the flexible circuit board (2), the top surfaces of the working electrode (21) and the counter electrode (22) are oppositely arranged, and a micro-channel (3) is formed between the opposite surfaces of the working electrode (21) and the counter electrode (22); an upper clamping groove (11) and a lower clamping groove (12) are formed in the shell (1);
the upper side clamping groove (11) is divided into a left upper clamping groove (111) and a right upper clamping groove (112), and a gap is reserved between the left upper clamping groove (111) and the right upper clamping groove (112);
the lower side clamping groove (12) is divided into a left side lower clamping groove (121) and a right side lower clamping groove (122), and a position between the left side lower clamping groove (121) and the right side lower clamping groove (122) is vacant;
the working electrode (21) and the counter electrode (22) are arranged to protrude out of the surface of the flexible circuit board (2);
the working electrode (21) is positioned in the middle of the flexible circuit board (2) in the width direction, and the edges of the flexible circuit board (2) on the two sides of the working electrode (21) are respectively clamped into the left upper clamping groove (111) and the right upper clamping groove (112);
the counter electrode (22) is located in the middle of the width direction of the flexible circuit board (2), and the edges of the flexible circuit board (2) on the two sides of the counter electrode (22) are respectively clamped into the left lower clamping groove (121) and the right lower clamping groove (122).
2. The structure of the micro-assembled biosensor according to claim 1, wherein the back end of the housing (1) extends out of the supporting arm (5), the bent portion of the flexible circuit board (2) is attached to the tail end of the supporting arm (5), and two inner surfaces of the bent portion of the flexible circuit board (2) are respectively attached to the upper and lower wall surfaces of the supporting arm (5).
3. The micropackaged biosensor structure of claim 2, wherein the support arm (5) extends rearwardly from the housing (1) between an upper (11) and a lower (12) side wall of the housing;
be provided with joint notch (51) on support arm (5), be provided with signal processing module (23) on flexible circuit board (2), signal processing module (23) card is gone into joint notch (51).
4. The micro-fabricated biosensor structure according to claim 1, wherein a branch flow channel (31) of the micro flow channel (3) is formed between both side walls of the working electrode (21) and the inner side wall of the housing (1).
5. The structure of miniature assembled biosensor according to claim 1, wherein the wall between the upper and lower clamping grooves (11, 12) is extended toward the middle by a support screen (8), the connection part of the support screen (8) and the wall is provided with a transition chamfer (9), and the working electrode (21) and the counter electrode (22) are provided with notches adapted to the transition chamfer (9); the working electrode (21) and the counter electrode (22) are respectively located on two sides of the support filter screen (8), and the distance between the top surfaces of the working electrode (21) and the counter electrode (22) is 50-300 mu m.
6. The micropackaged biosensor structure of claim 1, wherein one of said working electrodes (21) and one of said counter electrodes (22) form a sensor unit;
the number of the sensor units is more than two, and a liquid containing micro-groove (4) is formed between the two sensor units.
7. The micropackaged biosensor structure of claim 1, wherein the side wall of the housing (1) is provided with a via (13), the via (13) being located at the outlet of the microchannel (3); the micro-channel (3) is provided with an inlet, and a filtering structure is arranged at the inlet; and a flow guide material is arranged in the micro flow channel (3).
8. A miniature assembled biosensor structure comprises a shell (1) and is characterized by further comprising a rigid-flexible board (6), wherein a working electrode (21) and a counter electrode (22) are arranged on the rigid-flexible board (6);
the flexible-rigid combined board (6) is bent, the flexible-rigid combined board (6) is clamped in the shell (1), the bending part of the flexible-rigid combined board (6) is a flexible circuit board (63), the working electrode (21) and the counter electrode (22) are respectively positioned on two opposite sides of the bent interior of the flexible-rigid combined board (6), the working electrode (21) and the counter electrode (22) are oppositely arranged, and a micro-channel (3) is formed between the working electrode (21) and the counter electrode (22);
a first hard circuit board (61) and a second hard circuit board (62) are respectively arranged at two ends of the soft and hard combined board (6), and the working electrode (21) is positioned on the first hard circuit board (61); the counter electrode (22) is positioned on the second hard circuit board (62);
an upper clamping groove (11) and a lower clamping groove (12) are formed in the shell (1);
the upper side clamping groove (11) is divided into a left upper clamping groove (111) and a right upper clamping groove (112), and a gap is reserved between the left upper clamping groove (111) and the right upper clamping groove (112);
the lower side clamping groove (12) is divided into a left side lower clamping groove (121) and a right side lower clamping groove (122), and a position between the left side lower clamping groove (121) and the right side lower clamping groove (122) is vacant;
two opposite surfaces of the bent inner part of the rigid-flexible printed circuit board (6) are respectively clamped into the left upper clamping groove (111) and the right upper clamping groove (112);
the other surfaces of the two opposite surfaces of the bent soft and hard combined plate (6) are respectively clamped into the left lower clamping groove (121) and the right lower clamping groove (122).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910984743.XA CN110702761B (en) | 2019-10-16 | 2019-10-16 | Miniature assembled biosensor structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910984743.XA CN110702761B (en) | 2019-10-16 | 2019-10-16 | Miniature assembled biosensor structure |
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| Publication Number | Publication Date |
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| CN110702761A CN110702761A (en) | 2020-01-17 |
| CN110702761B true CN110702761B (en) | 2022-02-08 |
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| CN201910984743.XA Active CN110702761B (en) | 2019-10-16 | 2019-10-16 | Miniature assembled biosensor structure |
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Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1167538A1 (en) * | 2000-06-30 | 2002-01-02 | Schibli Engineering GmbH | Biosensor and method for its production |
| JP4038575B2 (en) * | 2003-07-25 | 2008-01-30 | 独立行政法人産業技術総合研究所 | Biosensor, biosensor device or biosensor storage method |
| JP4576624B2 (en) * | 2005-03-02 | 2010-11-10 | 独立行政法人産業技術総合研究所 | Needle integrated biosensor |
| PL2658444T3 (en) * | 2010-12-30 | 2015-04-30 | Hoffmann La Roche | Method for providing an efficient biosensor, as well as corresponding biosensor, substrate and insertion kit |
| US9493807B2 (en) * | 2012-05-25 | 2016-11-15 | Medtronic Minimed, Inc. | Foldover sensors and methods for making and using them |
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Address after: 518000 1208, Tsinghua Information Port scientific research building, west side of South Gate, No. 13, Langshan Road, songpingshan community, Xili street, Nanshan District, Shenzhen, Guangdong Province Patentee after: Shenzhen refresh biosensor technology Co.,Ltd. Address before: 518000 F3, 3D building, Tianjing building, Tian'an Digital City, Tairan fifth road, Tian'an community, Shatou street, Futian District, Shenzhen, Guangdong 83D302A Patentee before: SHENZHEN REFRESH INTELLIGENT TECHNOLOGY Co.,Ltd. |
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