CN110694079A - Gastrointestinal tract contrast imaging agent and preparation method thereof - Google Patents
Gastrointestinal tract contrast imaging agent and preparation method thereof Download PDFInfo
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- CN110694079A CN110694079A CN201911117658.XA CN201911117658A CN110694079A CN 110694079 A CN110694079 A CN 110694079A CN 201911117658 A CN201911117658 A CN 201911117658A CN 110694079 A CN110694079 A CN 110694079A
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- gastrointestinal tract
- preparation
- shell
- barium sulfate
- imaging agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0404—X-ray contrast preparations containing barium sulfate
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B11/00—Machines or apparatus for drying solid materials or objects with movement which is non-progressive
- F26B11/12—Machines or apparatus for drying solid materials or objects with movement which is non-progressive in stationary drums or other mainly-closed receptacles with moving stirring devices
- F26B11/14—Machines or apparatus for drying solid materials or objects with movement which is non-progressive in stationary drums or other mainly-closed receptacles with moving stirring devices the stirring device moving in a horizontal or slightly-inclined plane
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
- F26B21/001—Drying-air generating units, e.g. movable, independent of drying enclosure
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/04—Agitating, stirring, or scraping devices
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention belongs to a gastrointestinal tract contrast imaging agent and a preparation method thereof, and the preparation components of the gastrointestinal tract contrast imaging agent are as follows by percentage: 40% of barium sulfate and 60% of silicon rubber; the preparation method comprises the following steps: grinding, stirring, hot pressing and injection molding; the grinding process comprises the following steps: milling barium sulfate into powder, and milling by using an intermittent vertical mill to obtain a powdery material; the gastrointestinal tract contrast imaging agent is solid and is prepared by adopting a silicon rubber material added with barium sulfate, and the gastrointestinal tract contrast imaging agent does not decompose after entering the digestive tract, has complete shape and clear image; the product has no stimulation to human body, and is finally discharged out of the body along with the feces through the peristalsis of the digestive tract; the tablet has various specifications, is clear to identify and convenient for clinical examination and use, and can be taken by a patient once and photographed once; the product performance is better, the imaging numerical value of CT is generally 1000 plus or minus 50HU, the display effect is clearer, each specification can be clearly identified under X-ray or CT imaging, and accurate examination results are provided for clinic.
Description
Technical Field
The invention belongs to the technical field of intestinal tract treatment, and particularly relates to a gastrointestinal tract contrast imaging agent and a preparation method thereof.
Background
The gastrointestinal tract contrast imaging agent is a product for gastrointestinal tract contrast imaging, has the characteristics of simplicity, safety, no pain and non-invasiveness, and is easily accepted by patients; the application range is wide, the traditional gastrointestinal tract contrast imaging agent is in a liquid state, is attached to the inner wall of a digestive tract after entering a human body, can stimulate the mucous membrane of the digestive tract, and is easy to remain; the developer in the technical scheme has no stimulation to a human body, is finally discharged out of the body along with excrement by the peristalsis of the digestive tract, has various specifications, is clearly identified, is convenient for clinical examination and use, and is taken by a patient once and is photographed once; the contrast traditional developer performance is better, and CT's formation of image numerical value is generally at 1000 + -50 HU, and the display effect is more clear, can guarantee under X ray or CT formation of image that each specification can be clear discern, provides accurate inspection result for the clinic.
Disclosure of Invention
In order to achieve the purpose, the invention adopts the technical scheme that the invention provides a gastrointestinal tract contrast imaging agent and a preparation method thereof, wherein the gastrointestinal tract contrast imaging agent comprises the following preparation components in percentage: 40% of barium sulfate and 60% of silicon rubber; the preparation method comprises the following steps: grinding, stirring, hot pressing and injection molding;
the grinding process comprises the following steps: milling barium sulfate into powder, and milling by using an intermittent vertical mill to obtain a powdery material;
the stirring process comprises the following steps: stirring the silicon rubber raw material into a viscous state by a stirrer, adding barium sulfate powder at the viscous state, and continuously stirring by the stirrer to uniformly mix the barium sulfate powder with the silicon rubber material, wherein the proportion of barium sulfate in each region in a container of the stirrer is required to meet the requirement, so that all parts of the developer can be developed clearly;
the hot pressing process comprises the following steps: feeding the mixed and stirred materials into a hot press for hot pressing, and carrying out hot press molding at the temperature of over 100 ℃;
the injection molding process comprises the following steps: and performing an injection molding process through an injection molding machine to enable the product to present a designed shape.
Preferably, after the injection molding process, the finished product is washed, dried, and inspected and delivered after the finishing step.
Preferably, the water quality requirement of the flushing process is pure water, the drying process is completed by adopting a dryer, and the arranging step is carried out manually.
Preferably, the dryer includes: shell, pivot, sieve water tank, sieve water hole, the case of blowing, filter mesh hole, fan, blade, air outlet, sealed upset portion and delivery port, the upper end of shell is open structure, the pivot transversely sets up in the shell, sieve the water tank suit in the pivot, the sieve water hole is opened sieve the lower terminal surface of water tank, the case intercommunication of blowing is in a side surface of shell, it is in to filter the mesh hole setting in the case of blowing, the fan sets up the incasement side surface of blowing, the blade suit is in the output of fan, the air outlet sets up the shell is located filter mesh hole's opposite face, sealed upset portion sets up the inside of shell, the delivery port sets up the lower terminal surface of shell.
Preferably, the sealing turn-over part includes: sealed lid, inlay dress inner panel, turn-over groove and swing arm, sealed lid sets up the opening part of shell, it sets up to inlay the dress inner panel the lower terminal surface of sealed lid, the turn-over groove is opened sealed covering, the fixed suit of swing arm is in just the upper end stretches out in the pivot the turn-over groove.
Compared with the prior art, the gastrointestinal tract contrast imaging agent has the advantages and positive effects that the gastrointestinal tract contrast imaging agent is solid and is prepared by adopting the silicon rubber material added with barium sulfate, and the gastrointestinal tract contrast imaging agent is not decomposed after entering the alimentary tract, has complete shape and clear image; the product has no stimulation to human body, and is finally discharged out of the body along with the feces through the peristalsis of the digestive tract; the tablet has various specifications, is clear to identify and convenient for clinical examination and use, and can be taken by a patient once and photographed once; the product performance is better, the imaging numerical value of CT is generally 1000 plus or minus 50HU, the display effect is clearer, each specification can be clearly identified under X-ray or CT imaging, and accurate examination results are provided for clinic.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:
FIG. 1 is a schematic diagram of a dryer for a gastrointestinal tract contrast imaging agent and a method for preparing the same;
FIG. 2 is a schematic diagram of the structure of a contrast imaging agent for gastrointestinal tract presented under X-ray;
shown in the figure: 1. a housing; 2. a rotating shaft; 3. screening the water tank; 4. water sieving holes; 5. a blow box; 6. filtering meshes; 7. a fan; 8. a blade; 9. an air outlet; 10. a water outlet; 11. a sealing cover; 12. embedding an inner plate; 13. a turnover groove; 14. a swing arm.
Detailed Description
In order that the above objects of the present invention can be more clearly understood, the present invention will be further described with reference to the following examples. It should be noted that the embodiments and features of the embodiments of the present application may be combined with each other without conflict.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and thus the present invention is not limited to the specific embodiments of the present disclosure.
The scheme is that the gastrointestinal tract contrast imaging agent comprises the following preparation components in percentage by weight: 40% of barium sulfate and 60% of silicon rubber; the preparation method comprises the following steps: grinding, stirring, hot pressing and injection molding;
the grinding process comprises the following steps: milling barium sulfate into powder, and milling by using an intermittent vertical mill to obtain a powdery material;
the stirring process comprises the following steps: stirring the silicon rubber raw material into a viscous state by a stirrer, adding barium sulfate powder at the viscous state, and continuously stirring by the stirrer to uniformly mix the barium sulfate powder with the silicon rubber material, wherein the proportion of barium sulfate in each region in a container of the stirrer is required to meet the requirement, so that all parts of the developer can be developed clearly;
the hot pressing process comprises the following steps: feeding the mixed and stirred materials into a hot press for hot pressing, and carrying out hot press molding at the temperature of over 100 ℃;
the injection molding process comprises the following steps: and performing an injection molding process through an injection molding machine to enable the product to present a designed shape.
In the scheme, after the injection molding process, a finished product is washed, dried, and inspected and delivered after the finishing step; the water quality requirement of the flushing process is pure water, the drying process is completed by adopting a dryer, and the arranging step is carried out manually.
Wherein as shown in fig. 1, the dryer includes: a shell 1, a rotating shaft 2, a water sieving tank 3, a water sieving hole 4, a blowing box 5, a filtering mesh 6, a fan 7, blades 8, an air outlet 9, a sealing turnover part and a water outlet 10, the upper end of the shell 1 is of an opening structure, the rotating shaft 2 is transversely arranged in the shell 1, the sieve water tank 3 is sleeved on the rotating shaft 2, the sieve water holes 4 are formed on the lower end surface of the sieve water tank 3, the air blowing box 5 is communicated with one side surface of the shell 1, the filter mesh 6 is arranged in the air blowing box 5, the fan 7 is arranged on the inner side surface of the blowing box 5, the blades 8 are sleeved at the output end of the fan 7, the air outlet 9 is arranged on the opposite surface of the shell 1 positioned on the filter mesh 6, the sealing turnover part is arranged inside the shell 1, and the water outlet 10 is arranged on the lower end surface of the shell 1.
In this above aspect, the sealing turnover part includes: the sealing cover 11, inlay dress inner panel 12, upset groove 13 and swing arm 14, sealing cover 11 sets up the opening part of shell 1, inlay the setting of dress inner panel 12 and be in the lower terminal surface of sealing cover 11, upset groove 13 is opened on the sealing cover 11, swing arm 14 fixed suit is in just the upper end stretches out on the pivot 2 upset groove 13.
Wherein, need emphatically point out, at the drying machine body implementation in-process, place finished product radiography granule in the sieve water tank, through sieve the water hole with attached to moisture on the finished product radiography granule and drip to drive the blade through the fan and air-dry, drive the pivot rotation through rocking the swing arm at air-dry in-process, make the pivot drive the sieve water tank at the in-process of rotation and carry out rotation angle, make the radiography granule process of improving the waterlogging caused by excessive rainfall more.
In the technical scheme, the product is used in the form that: patients were allowed to swallow the gastrointestinal contrast imaging agent orally with water 24 capsules at a time on the first day. The product shape design is suitable for oral swallowing, so the product shape is basically designed into six specifications of a circle and a strip, the structural shapes are shown in figure 2, and different structures are determined by adopting the structure of a mold by an injection molding machine in the injection molding process.
The above description is only a preferred embodiment of the present invention, and not intended to limit the present invention in other forms, and any person skilled in the art may apply the above modifications or changes to the equivalent embodiments with equivalent changes, without departing from the technical spirit of the present invention, and any simple modification, equivalent change and change made to the above embodiments according to the technical spirit of the present invention still belong to the protection scope of the technical spirit of the present invention.
Claims (5)
1. A gastrointestinal tract contrast imaging agent and a preparation method thereof are characterized in that the preparation components are as follows according to percentage: 40% of barium sulfate and 60% of silicon rubber; the preparation method comprises the following steps: grinding, stirring, hot pressing and injection molding;
the grinding process comprises the following steps: milling barium sulfate into powder, and milling by using an intermittent vertical mill to obtain a powdery material;
the stirring process comprises the following steps: stirring the silicon rubber raw material into a viscous state by a stirrer, adding barium sulfate powder at the viscous state, and continuously stirring by the stirrer to uniformly mix the barium sulfate powder with the silicon rubber material, wherein the proportion of barium sulfate in each region in a container of the stirrer is required to meet the requirement, so that all parts of the developer can be developed clearly;
the hot pressing process comprises the following steps: feeding the mixed and stirred materials into a hot press for hot pressing, and carrying out hot press molding at the temperature of over 100 ℃;
the injection molding process comprises the following steps: and performing an injection molding process through an injection molding machine to enable the product to present a designed shape.
2. The contrast medium for gastrointestinal tract use according to claim 1, wherein the injection molding process is followed by rinsing, drying, finishing and inspection.
3. The contrast medium for gastrointestinal tract imaging and the preparation method thereof according to claim 2, wherein the water quality of the flushing process is required to be pure water, the drying process is completed by using a dryer, and the finishing step is manually performed by stacking.
4. The contrast agent for gastrointestinal tract and the preparation method thereof according to claim 3, wherein the dryer comprises: the air filter comprises a shell (1), a rotating shaft (2), a sieve water tank (3), a sieve water hole (4), a blowing box (5), a filter mesh (6), a fan (7), blades (8), an air outlet (9), a sealing turnover part and a water outlet (10), wherein the upper end of the shell (1) is of an open structure, the rotating shaft (2) is transversely arranged in the shell (1), the sieve water tank (3) is sleeved on the rotating shaft (2), the sieve water hole (4) is arranged on the lower end face of the sieve water tank (3), the blowing box (5) is communicated with one side surface of the shell (1), the filter mesh (6) is arranged in the blowing box (5), the fan (7) is arranged on the inner side surface of the blowing box (5), the blades (8) are sleeved on the output end of the fan (7), the air outlet (9) is arranged on the opposite face of the shell (1) which is positioned in the filter mesh (6), the sealing turnover part is arranged in the shell (1), and the water outlet (10) is arranged on the lower end face of the shell (1).
5. The contrast agent for gastrointestinal tract and the preparation method thereof according to claim 4, wherein the sealing flip part comprises: sealed lid (11), inlay dress inner panel (12), upset groove (13) and swing arm (14), sealed lid (11) set up the opening part of shell (1), inlay dress inner panel (12) and set up the lower terminal surface of sealed lid (11), upset groove (13) are opened on sealed lid (11), swing arm (14) fixed suit is in pivot (2) are gone up and the upper end stretches out upset groove (13).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911117658.XA CN110694079A (en) | 2019-11-14 | 2019-11-14 | Gastrointestinal tract contrast imaging agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911117658.XA CN110694079A (en) | 2019-11-14 | 2019-11-14 | Gastrointestinal tract contrast imaging agent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110694079A true CN110694079A (en) | 2020-01-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911117658.XA Withdrawn CN110694079A (en) | 2019-11-14 | 2019-11-14 | Gastrointestinal tract contrast imaging agent and preparation method thereof |
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| Country | Link |
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| CN (1) | CN110694079A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112226086A (en) * | 2020-09-30 | 2021-01-15 | 广东安格尔橡塑科技有限公司 | Material capable of detecting silica gel ball and preparation method thereof |
-
2019
- 2019-11-14 CN CN201911117658.XA patent/CN110694079A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112226086A (en) * | 2020-09-30 | 2021-01-15 | 广东安格尔橡塑科技有限公司 | Material capable of detecting silica gel ball and preparation method thereof |
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Application publication date: 20200117 |
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| WW01 | Invention patent application withdrawn after publication |