CN110680576A

CN110680576A - Self-expanding medicine slow release stent and taking and placing device thereof

Info

Publication number: CN110680576A
Application number: CN201911013302.1A
Authority: CN
Inventors: 余洪猛; 许伦; 王丽; 杨海
Original assignee: Lechang Medical Instruments (shanghai) Co Ltd
Current assignee: Lechang Medical Instruments (shanghai) Co Ltd
Priority date: 2019-10-23
Filing date: 2019-10-23
Publication date: 2020-01-14

Abstract

The invention relates to a self-expanding medicine slow release stent and a taking and placing device thereof, relating to the technical field of ear-nose-throat medical instruments. One of the self-expanding medicine slow release stents comprises a slow release stent, a self-expanding component, a connecting piece and symptomatic medicine; the self-expansion assembly comprises a positioning rod, a first elastic piece, a first sliding piece, a second sliding piece, a third sliding piece and a plurality of expansion branch strips, is convenient for propping open nasal polyps at the pathological change positions of patients, and further expands along with the atrophy of the nasal polyps weakened by the patients, so that the precise medicine application is realized, the treatment period is shortened, and the treatment effect is fully ensured. The utility model provides a get and put device that is used for above-mentioned self-expanding medicine slowly-releasing support, places sleeve pipe, joint spare including first sleeve pipe, the second of placing, and the convenient of easy and simple to handle being convenient for realize the sinus support gets and puts, improves the convenience of doctor's operation greatly, avoids operation risk and postoperative sequelae risk.

Description

Self-expanding medicine slow release stent and taking and placing device thereof

Technical Field

The invention relates to the technical field of ear-nose-throat medical instruments, in particular to a self-expanding medicine slow release stent and a taking and placing device thereof.

Background

The paranasal sinuses, also called paranasal sinuses and paranasal sinuses, are a plurality of air-containing bone cavities around the nasal cavity. The mucosa of the nasal sinuses is connected with the nasal mucosa, so the mucosa of the nasal cavity is inflamed and often spread to the mucosa of the sinus cavities, and nasosinusitis is caused. It is presently believed that the cause of sinusitis is primarily infection within the sinuses due to obstruction of the ostia by various causes, with nasal polyps being the major cause of obstruction of the sinus ostia, and inflammatory stimulation of the sinuses in turn promotes growth of the nasal polyps, forming a vicious circle.

The current treatment methods of nasosinusitis mainly comprise nasal administration, nasoscope paranasal sinus surgery and the like. Among these, intranasal subthalangeal sinus surgery is the currently preferred treatment. The nasal endoscope paranasal sinus operation can thoroughly eliminate pathological changes of each paranasal sinus, fully open each paranasal sinus ostium, improve paranasal sinus drainage, and keep normal tissues as far as possible, and is a minimally invasive operation with functions as far as possible.

The Chinese invention with the publication number of CN109394399A provides a drug sustained-release stent which is characterized by comprising a stent and a polymer film, wherein the stent and the polymer film are connected together, the polymer film is a degradable polymer film or a non-degradable polymer film, at least one layer of drug coating is arranged on the polymer film and/or the stent, and the drug coating contains one or more of antibacterial drugs, anti-inflammatory drugs, anti-cancer drugs and hemostatic drugs. The drug sustained-release stent is applied to the treatment of nasosinusitis, can play a role in supporting and continuously administering the lesion position after FESS operation, and also can play a role in stopping bleeding after the operation.

The above prior art solutions have the following drawbacks: FESS surgery is expensive and has a high recurrence rate, the recurrence rate after surgical removal of nasal polyps is 30% -50%, each patient should be subjected to at least 1.5-4 surgeries on average, because the supporting strength of the drug sustained-release stent is low, the anatomical structures such as turbinates, nasal septum, nasal mucosa, nasal polyps and the like are often required to be removed in the surgery, and such removal and reconstruction surgeries may destroy the natural filtering and humidifying functions provided by the structures, cause dryness, bleeding, scabbing, increase the risk of infection, and possibly cause olfactory changes including hyposmia, olfactory disorder, olfactory fall and loss.

If the mode of directly administering the medicine through the nasal cavity is adopted for conservative treatment, because the diseased nasal sinuses are blocked by nasal tissues such as swollen nasal polyps, the medicine slow-release bracket has insufficient rigidity, can not directly extrude and support the nasal polyps, dilates the sinus ostia, and the medicine can not directly and accurately reach the diseased regions, so that the medicine treatment is very slow, the nasal polyps can not be cured radically in time, and the sinus ostia can still be blocked for a long time, and the treatment period is too long.

Disclosure of Invention

The invention aims to provide a self-expanding medicine slow-release stent which is convenient for supporting and expanding nasal polyps at a diseased part of a patient.

The above object of the present invention is achieved by the following technical solutions: a self-expandable drug sustained-release stent comprises a self-expandable stent composition, wherein the self-expandable stent composition comprises a sustained-release stent, a self-expandable component and a connecting piece; the slow release bracket is provided with symptomatic medicines;

the self-expansion assembly comprises a positioning rod, a first elastic piece and a plurality of expansion support bars, wherein one end of the positioning rod forms a fixed end, and the other end of the positioning rod is provided with a first sliding piece; two ends of the expansion branch are respectively connected with the fixed end and the first sliding piece; the first elastic piece applies pulling force to the first sliding piece and drives the first sliding piece to move relatively towards the direction close to the fixed end;

the connecting piece comprises a plurality of positioning heads and positioning grooves, the positioning heads are located in the middle of one side, away from the positioning rod, of the expansion branch, the positioning grooves are located on the inner periphery side of the slow release support, and the positioning heads and the positioning grooves are in one-to-one correspondence and are in plug-in fit.

By adopting the technical scheme, when in use, a doctor firstly correspondingly inserts and matches the positioning heads of the expansion branch bars and the positioning grooves of the slow-release stent one by one, and then the slow-release stent and the self-expanding component are pre-connected through the connecting piece to form the self-expanding stent composition; then the self-expanding stent composition is integrally inserted into the nasal cavity of a patient, the first sliding piece is released, the first sliding piece moves relatively towards the direction close to the fixed end under the action of the first elastic piece, the expansion branch piece expands towards the direction far away from the positioning rod, the support slow-release stent props up nasal polyps, symptomatic medicines arranged on the slow-release stent are accurately applied to a diseased part, the medicine treatment effect is ensured, the treatment period is shortened, and the risks of dryness, bleeding, scabbing, infection and the like caused by the removal of anatomical structures such as turbinates, nasal septa, nasal mucosa, nasal polyps and the like in an operation and the change of smell caused by the complications such as hyposmia, dysosmia, wrong smell falling, loss of smell and the like are avoided.

The invention is further configured to: the positioning rod is also provided with a second sliding piece and a third sliding piece, and the second sliding piece and the third sliding piece are sequentially positioned between the first sliding piece and the fixed end; the expansion branch bars are provided with three groups along the axial direction of the positioning rod, and the expansion branch bars are respectively a first expansion part, a second expansion part and a third expansion part from far to near from the fixed end;

the first expansion part, the second expansion part and the third expansion part respectively at least comprise three expansion branch bars which are uniformly arranged along the circumferential direction of the positioning rod;

the two ends of each expansion branch in the first expansion part are respectively connected with the first sliding part and the second sliding part, the two ends of each expansion branch in the second expansion part are respectively connected with the second sliding part and the third sliding part, and the two ends of each expansion branch in the third expansion part are respectively connected with the third sliding part and the fixed end;

the positioning head is positioned in the middle of one side, away from the positioning rod, of each expansion branch in the second expansion part.

By adopting the technical scheme, when in use, a doctor firstly correspondingly inserts and matches the positioning heads of the expansion branch bars of the second expansion part and the positioning grooves of the slow-release stent one by one, so that the slow-release stent and the self-expansion assembly are pre-connected through the connecting piece and combined to form the self-expansion stent composition; then inserting the self-expanding stent composition into the nasal cavity of the patient in a whole manner so that the expansion branch of the second expansion part is positioned at the position with the minimum diameter of the sinus ostium; release first sliding member, make first sliding member under the effect of first elastic component, to the direction relative motion who is close to the stiff end, first inflation portion, the second inflation portion, the inflation branch of third inflation portion expands to the direction of keeping away from the locating lever respectively, first inflation portion, the pressure that the inflation branch of third inflation portion received is less than the inflation branch of second inflation portion, consequently under the expansion effect of the inflation branch of first inflation portion, the second inflation portion, the third inflation portion, the diameter at the slow release support both ends after the expansion is greater than middle diameter, avoid slow release support to remove along its axis and drop, lead to the unable release of symptomatic medicine on pathological change position.

The invention is further configured to: the positioning groove is respectively provided with sliding grooves along the two axial sides of the slow release support, and sliding heads are respectively arranged in the middle parts of the expansion branch bars in the first expansion part and the third expansion part, which are far away from one side of the positioning rod, and are connected with the sliding grooves in a sliding manner.

Through adopting above-mentioned technical scheme, the head that slides is connected with the groove that slides, is convenient for slide the head at the inflation in-process and set up the direction motion along the groove that slides.

The invention is further configured to: and one end of the sliding groove, which is far away from the positioning groove, is provided with a baffle respectively.

Through adopting above-mentioned technical scheme, avoid deviating from the groove of sliding when the head that slides removes the one end of keeping away from the constant head tank to the groove of sliding from the inflation subassembly inflation in-process, the head and the baffle looks butt of sliding when the head that slides removes the one end of keeping away from the constant head tank to the groove of sliding, the expansion force that the slowly-releasing support both ends received is bigger, and its diameter is bigger, is convenient for avoid slowly-releasing support to remove along its axis and drops.

The invention is further configured to: the positioning head comprises a positioning part and a clamping part which are coaxially arranged, the clamping part is fixedly connected with the expansion branch, and the positioning part is fixedly connected with the clamping part; the locating part keeps away from the ascending sectional area in locating lever direction along its axis and reduces in proper order, joint portion keeps away from the ascending sectional area in locating lever direction along its axis and increases in proper order, the sectional area of locating part and joint portion junction equals, the constant head tank cooperates with the location head grafting.

Through adopting above-mentioned technical scheme, the one end sectional area that the locating lever was kept away from to location portion is less, is convenient for correspond the cooperation of pegging graft with the constant head tank, and the effect through first elastic component makes joint portion, location portion and constant head tank grafting cooperation, strengthens the stability between self-expanding assembly and the slow release support.

The invention is further configured to: the positioning part and the clamping part are evenly provided with a plurality of notches along the circumferential direction.

By adopting the technical scheme, the space which is contracted towards the direction close to the central axis of the positioning part and the clamping part is provided for the positioning part and the clamping part, the positioning part and the clamping part penetrate through the opening of the positioning groove, and the part to be positioned and the clamping part enter the inner cavity of the positioning groove and recover to the original shape to form clamping.

The invention is further configured to: the slow release support comprises slow release microtubes, and the slow release microtubes are in cross connection to form a slow release support with a ring-shaped net structure.

By adopting the technical scheme, the crossed net structure is convenient for compression before use and extends along with the self-expanding component in use, the deformation effect is good, the sinus cavity or sinus ostia is prevented from being completely blocked, and the sinus ostia skin is prevented from being completely covered by the slow release stent to influence the biological function of the slow release stent.

The invention is further configured to: the periphery of the slow release bracket is provided with a drug slow release layer, and symptomatic drugs are arranged on the drug slow release layer and comprise one or more of antibacterial drugs, anti-inflammatory drugs, anti-cancer drugs and hemostatic drugs.

By adopting the technical scheme, the symptomatic medicine arranged on the medicine slow release layer is used for treating the disease in the early stage, and the medicine slow release layer deforms along with the slow release bracket and clings to the affected part, so that the symptomatic medicine arranged on the medicine slow release layer can be accurately applied to the diseased part.

The invention is further configured to: the interior of the slow release microtube is hollow, slow release or later release medicines are filled in the slow release microtube, and slow release micropores are formed in the surface of the slow release microtube.

Through adopting above-mentioned technical scheme, in the use later stage of self-expanding medicine slow-release support, when the symptomatic medicine consumption on slow-release support surface and the medicine slow-release layer is totally up, the slow release or the later stage release medicine that slow-release microtubule inside was filled play a role, prolongs treatment cycle, ensures therapeutic effect.

In order to achieve the above object, another technical solution provided by the present invention is: the taking and placing device applied to the self-expandable drug sustained-release stent comprises a first placing sleeve, wherein the first placing sleeve is hollow; a plurality of track grooves are uniformly distributed on the first placing sleeve along the circumferential direction of the first placing sleeve, are formed along the axial direction of the first placing sleeve and correspond to the positioning heads one by one;

a clamping piece is arranged in the first placing sleeve and comprises a plurality of clamping jaws, an inner push rod and a second elastic piece, and an annular clamping groove is formed in the outer peripheral side of the first sliding piece; one end of the clamping jaw is hinged with one end of the inner push rod close to the positioning rod, and the other end of the clamping jaw is provided with a butting part which is in splicing fit with the clamping groove; the second elastic piece drives one end, far away from the inner push rod, of the clamping jaw to rotate towards the direction close to the inner push rod;

a second placing sleeve is fixedly sleeved on the outer peripheral side of the first placing sleeve, and an annular placing cavity is formed between the first placing sleeve and the second placing sleeve.

By adopting the technical scheme, before the self-expanding medicine slow-release stent is placed, the slow-release stent is placed into the annular placing cavity between the first placing sleeve and the second placing sleeve, so that the positioning groove and the track groove are correspondingly exposed; then, a doctor clamps the clamping groove of the first sliding piece through the clamping jaw, applies a force far away from the fixed end to enable each elastic supporting strip to be in an unexpanded and bent state, places the elastic supporting strip into the first placing sleeve, reduces the force far away from the fixed end applied to the clamping groove of the first sliding piece, enables the self-expansion assembly to slightly expand, enables the positioning part of the positioning head to be abutted against the inner side wall of the first placing sleeve, aligns the positioning part of the positioning head with the positioning groove to enable the positioning groove to be same in horizontal height, slowly rotates the self-expansion assembly, enables the positioning head of the self-expansion assembly to be in inserting fit with the positioning groove of the slow-release support, and enables the sliding head and the sliding groove to enter a; then, the doctor puts the second placing sleeve into the affected part of the patient, applies force towards the direction of the positioning rod to the inner push rod, pushes the self-expanding component and the slow release bracket part out to be abutted against the affected part, and after finding a proper position, completely pushes the self-expanding component and the slow release bracket out, the middle part of the slow release bracket is abutted against the minimum diameter part of the affected part, the sliding heads of the first expanding part and the third expanding part move along the sliding groove under the action of expansion force to be abutted against the baffle plate to form a horn-shaped opening, so that the slow release bracket is prevented from moving and falling off along the axis of the slow release bracket; the slow release bracket supports the affected part under the acting force of the self-expansion assembly, so that symptomatic medicines arranged on the slow release bracket can be accurately released at the affected part.

In conclusion, the beneficial technical effects of the invention are as follows:

1. the expansion branch strips are driven to bend and expand by the arrangement of the first sliding piece and the first elastic piece, nasal polyps at the pathological change positions of patients are propped open, the expansion branch strips further expand along with the reduction of the illness states of the patients, the supply of medicines is always kept, the accurate medicine application is convenient to realize, the treatment effect is fully ensured, the treatment period is favorably shortened, the effective treatment of the nasosinusitis is ensured, the recurrence rate of the nasosinusitis is reduced, and the possible sequelae caused by the nasal sinus operation under a nasal endoscope are avoided;

2. preferably, the slow-release or later-release medicament filled in the medicament slow-release layer or the slow-release microtube can realize accurate administration in the early stage and ensure the administration time, the duration of the treatment course is sufficient, the pathological change part of a patient is comprehensively treated, and the treatment effect is further improved;

3. through first sleeve pipe, the second of placing place getting of sleeve pipe, joint spare constitution and put the device, realize the convenient of sinus support and get and put, improve the convenience of doctor's operation greatly.

Drawings

FIG. 1 is a schematic view of the overall structure of embodiment 1 of the present invention;

FIG. 2 is a partial structural schematic view of the self-expanding assembly of example 1 of the present invention to show it;

FIG. 3 is an enlarged schematic view of portion A of FIG. 2;

FIG. 4 is a partial structural view of examples 1 to 5 of the present invention for showing a sustained-release stent;

FIG. 5 is an enlarged schematic view of portion B of FIG. 4;

FIG. 6 is a schematic view showing a state of use of embodiment 1 of the present invention;

FIG. 7 is a schematic view showing the overall structure of embodiment 2 and embodiment 4 of the present invention;

FIG. 8 is a partial structural view of the self-expanding assembly of example 2 of the present invention to show it;

FIG. 9 is a schematic view showing a state of use of embodiment 2 of the present invention;

FIG. 10 is a schematic view of the overall structure of embodiment 3 of the present invention;

FIG. 11 is a schematic view of the overall structure of embodiment 5 of the present invention;

FIG. 12 is a schematic view of a partial cross-sectional structure of example 5 of the present invention;

reference numerals: 1. a slow release stent; 11. slow release microtubules; 111. slow release micropores; 2. a self-expanding assembly; 21. positioning a rod; 211. a fixed end; 212. a first glide; 2121. a card slot; 2122. a reserved section; 2123. disassembling the section; 213. A second glide; 214. a third glide; 22. a first elastic member; 23. expanding the branch; 24. a first expansion section; 25. a second expansion section; 26. a third expansion section; 3. a connecting member; 31. positioning the head; 311. a positioning part; 312. a clamping part; 313. a notch; 32. positioning a groove; 33. a slipping head; 34. a sliding groove; 35. a baffle plate; 4. a drug sustained release layer; 5. a first placement sleeve; 51. a track groove; 6. a second placement sleeve; 7. a clamping piece; 71. a claw; 72. an inner push rod; 73. a second elastic member.

Detailed Description

The embodiment aims at providing assembled intelligent glasses. The present invention will be described in further detail with reference to the accompanying drawings. In which like parts are designated by like reference numerals. It should be noted that the terms "front," "back," "left," "right," "upper" and "lower" used in the following description refer to directions in the drawings, and the terms "bottom" and "top," "inner" and "outer" refer to directions toward and away from, respectively, the geometric center of a particular component.

The first embodiment is as follows:

referring to fig. 1, a self-expandable drug sustained-release stent 1 comprises a self-expandable stent composition, wherein the self-expandable stent composition comprises a sustained-release stent 1, a self-expandable component 2 and a connecting piece 3; the slow release support 1 comprises slow release microtubes 11, the slow release microtubes 11 are connected in a cross mode to form the slow release support 1 with an annular net structure, and symptomatic medicines are arranged on the slow release support 1.

The symptomatic medicine comprises one or more of antibacterial drugs, anti-inflammatory drugs, anticancer drugs and hemostatic drugs, and can be contacted with the nasal cavity wall and polyp and released, so that the regrowth of the polyp is inhibited, and the inflammation of the nasal cavity is reduced; the self-expanding stent composition can be processed by stainless steel, cobalt-chromium alloy, nickel-titanium alloy, magnesium alloy and other materials, can also be formed by degradable metals such as magnesium, pure iron and the like, and can also be processed by degradable high polymer materials.

Referring to fig. 2, the self-expanding assembly 2 includes a cylindrical positioning rod 21, one end of the positioning rod 21 forms a fixed end 211, and the other end of the positioning rod 21 is provided with a first sliding member 212, and the first sliding member 212 is movably sleeved on the periphery of the positioning rod 21 and can flexibly slide along the axial direction of the positioning rod 21; the self-expanding assembly 2 further comprises four strip-shaped expansion branches 23 uniformly distributed on the periphery of the positioning rod 21, and two ends of each expansion branch 23 are respectively connected with the fixed end 211 and the first sliding piece 212; the self-expanding assembly 2 further includes a first elastic member 22 sleeved on the outer periphery of the positioning rod 21, the first elastic member 22 is an extension spring, and the first elastic member 22 applies a pulling force to the first sliding member 212 and drives the first sliding member 212 to move relatively in a direction close to the fixed end 211.

Referring to fig. 3, 4 and 5, the connecting member 3 includes four positioning heads 31 and four positioning grooves 32, and the four positioning heads 31 are respectively located in the middle of one side of the expansion branch 23 away from the positioning rod 21; the positioning head 31 comprises a positioning part 311 and a clamping part 312 which are coaxially arranged, the clamping part 312 is fixedly connected with the expansion branch 23, and the positioning part 311 is fixedly connected with the clamping part 312; the sectional area of the positioning part 311 along the axis far away from the positioning rod 21 is sequentially reduced, the sectional area of the clamping part 312 along the axis far away from the positioning rod 21 is sequentially increased, the sectional area of the connecting part of the positioning part 311 and the clamping part 312 is equal, and four notches 313 are uniformly formed in the circumferential direction of the positioning part 311 and the clamping part 312; the positioning grooves 32 are uniformly distributed in the middle of the inner peripheral side of the slow release support 1, and the positioning heads 31 correspond to the positioning grooves 32 one by one and are in splicing fit.

In the initial state, each expansion branch 23 is in a straight state, and when the first sliding member 212 is released, the first elastic member 22 exerts a pulling force on the first sliding member 212 and drives the first sliding member 212 to move relatively in a direction close to the fixed end 211, each expansion branch 23 is bent and expanded in a direction away from the positioning rod 21.

Referring to fig. 6, in the actual use process, a doctor firstly inserts and fits the positioning head 31 of the expansion branch 23 and the positioning groove 32 of the slow-release stent 1 in a one-to-one correspondence manner, places the slow-release stent 1 and the self-expansion assembly 2 in the initial state into the affected part of a patient, releases the first sliding piece 212, makes the first sliding piece 212 relatively move in the direction close to the fixed end 211 under the action of the first elastic piece 22, expands the expansion branch 23 in the direction away from the positioning rod 21, supports the slow-release stent 1 to prop open the nasal polyp, and realizes the stable erection of the sinus stent. At this time, the sustained-release stent 1 is in contact with the nasal cavity wall or polyp, and the symptomatic medicine in the sustained-release medicine layer is gradually released, so that the diseased region of a patient is effectively treated, the medicine treatment effect is ensured, the treatment period is shortened, and the risks of dryness, bleeding, scabbing, infection and the like caused by the removal of anatomical structures such as turbinates, nasal septum, nasal mucosa, nasal polyp and the like in an operation and the complications such as olfactory decline, olfactory disorder, olfactory collapse, olfactory loss and the like are avoided.

Example two:

referring to fig. 7 and 8, a self-expandable drug-eluting stent 1 is different from the first embodiment in that a second sliding member 213 and a third sliding member 214 are further disposed on the positioning rod 21, and the second sliding member 213 and the third sliding member 214 are sequentially disposed between the first sliding member 212 and the fixed end 211; the expansion branch bars 23 are provided with three groups along the axial direction of the positioning rod 21, and the expansion branch bars are respectively a first expansion part 24, a second expansion part 25 and a third expansion part 26 from far to near from the fixed end 211.

The first expansion part 24, the second expansion part 25 and the third expansion part 26 respectively comprise four expansion branch bars 23 which are uniformly arranged along the circumferential direction of the positioning rod 21; two ends of each expansion branch 23 in the first expansion part 24 are respectively connected with the first sliding part 212 and the second sliding part 213, two ends of each expansion branch 23 in the second expansion part 25 are respectively connected with the second sliding part 213 and the third sliding part 214, and two ends of each expansion branch 23 in the third expansion part 26 are respectively connected with the third sliding part 214 and the fixed end 211.

The positioning head 31 is positioned in the middle of one side of each expansion branch 23 far away from the positioning rod 21 in the second expansion part 25, the positioning groove 32 is respectively provided with a sliding groove 34 along two axial sides of the slow release support 1, and one end of the sliding groove 34 far away from the positioning groove 32 is respectively provided with a baffle 35; the middle parts of the expansion branches 23 of the first expansion part 24 and the third expansion part 26, which are far away from the positioning rod 21, are respectively provided with a sliding head 33, and the sliding heads 33 are connected with a sliding groove 34 in a sliding manner.

In an initial state, each expansion branch 23 is in a straight state, the positioning head 31 is correspondingly inserted and matched with the positioning groove 32, and the sliding heads 33 are respectively abutted against the middle parts of the corresponding sliding grooves 34; when the first slider 212 is released and the first elastic member 22 applies a tensile force to the first slider 212 to drive the first slider 212 to move relatively in a direction approaching the fixed end 211, the expansion stays 23 of the first expansion portion 24, the second expansion portion 25, and the third expansion portion 26 are bent and expanded in a direction away from the positioning rod 21.

Referring to fig. 9, in the practical use process, a doctor firstly inserts and fits the positioning heads 31 of the expansion branches 23 and the positioning grooves 32 of the slow-release stent 1 in a one-to-one correspondence manner, so that the sliding heads 33 are abutted against the corresponding sliding tracks, places the slow-release stent 1 and the self-expanding component 2 in the initial state into the affected part of a patient, releases the first sliding member 212, so that the first sliding member 212 relatively moves in the direction close to the fixed end 211 under the action of the first elastic member 22, the expansion branches 23 of the first expansion part 24, the second expansion part 25 and the third expansion part 26 expand in the direction far from the positioning rod 21, the expansion branches 23 of the second expansion part 25 support the slow-release stent 1 to prop open nasal polyps, the pressure applied to the expansion branches 23 of the first expansion part 24 and the third expansion part 26 is smaller than the expansion branches 23 of the second expansion part 25, so that the expansion diameters of the first expansion part 24 and the third part 26 are larger than the expansion diameter of the second expansion part 25, the sliding head 33 is connected with the elastic sliding groove 34 and the baffle 35 in a butting way, and the slow release support 1 forms a horn shape at two ends under the action of the self-expanding component 2, so that the slow release support 1 is prevented from moving and falling off along the axis of the slow release support, and the stable erection of the sinus support is convenient to realize. At the moment, the slow release bracket 1 is contacted with the nasal cavity wall or the polyp, and the symptomatic medicine in the slow release medicine layer on the slow release bracket is gradually released, so that the pathological change part of a patient is effectively treated, the medicine treatment effect is ensured, the treatment period is shortened, and the surgical complications are avoided.

Example three:

referring to fig. 10, a self-expandable stent 1 is different from the second embodiment in that a drug release layer 4 is disposed on the outer circumferential side of the stent 1, the drug release layer 4 has elasticity, and symptomatic drugs including one or more of antibacterial drugs, anti-inflammatory drugs, anticancer drugs, and hemostatic drugs are uniformly disposed on the drug release layer 4.

In the actual use process, the trumpet-shaped self-expanding stent composition supports the compression of nasal polyps at the affected part of a patient, the medicine slow-release layer 4 accurately covers the diseased part and forms a specific shape at the specific shape of the diseased part, so that the symptomatic medicine can be accurately and uniformly applied to each part of the diseased part.

Example four:

referring to the attached drawings 4 and 7, the self-expandable drug sustained-release stent 1 is different from the third embodiment in that the interior of the sustained-release microtube 11 is hollow, sustained-release micropores 111 are formed in the surface of the sustained-release microtube 11, and the interior of the sustained-release microtube 11 is filled with a slow-release or late-release drug.

In the actual use process, in the later stage of the use process of the self-expandable drug slow-release stent 1, when the consumption of the symptomatic drugs on the outer surface of the slow-release stent 1 and the drug slow-release layer 4 is almost zero, the slow-release or later-release drugs filled in the slow-release microtube 11 gradually diffuse to the pathological change part to exert the therapeutic effect, the treatment period is prolonged, and the therapeutic effect is ensured.

Example five:

referring to fig. 11, the taking and placing device for the self-expandable drug sustained-release stent 1 comprises a first placing sleeve 5 which is hollow in the inside and in a circular tube shape, wherein four track grooves 51 are uniformly distributed on the first placing sleeve 5 along the circumferential direction of the first placing sleeve 5, and the track grooves 51 are formed along the axial direction of the first placing sleeve 5 and respectively correspond to a positioning head 31, a positioning groove 32, a sliding head 33 and a sliding groove 34; the outer peripheral side of the first placing sleeve 5 is fixedly sleeved with a second placing sleeve 6 in a circular tube shape, and an annular placing cavity is formed between the first placing sleeve 5 and the second placing sleeve 6.

Referring to fig. 12, a clamping member 7 is arranged inside the first placing sleeve 5, the clamping member 7 includes four L-shaped jaws 71, a cylindrical inner push rod 72, and a second elastic member 73, an annular clamping groove 2121 is arranged on the outer peripheral side of the first sliding member 212, the first sliding member 212 is divided into a retaining section 2122 and a detaching section 2123 by using the clamping groove 2121 as a boundary, and the retaining section 2122 is detachably connected with the detaching section 2123 by means of insertion or threaded connection; one end of the clamping jaw 71 is hinged with one end of the inner push rod 72 close to the positioning rod 21, and the other end of the clamping jaw is provided with a butting part which is spliced and matched with the clamping groove 2121; the second elastic member 73 drives one end of the jaw 71 away from the inner push rod 72 to rotate towards the direction approaching the inner push rod 72.

In the actual use process, a doctor firstly puts the sustained-release stent 1 into the annular placing cavity between the first placing sleeve 5 and the second placing sleeve 6, so that the positioning groove 32 and the track groove 51 are correspondingly exposed; then, the doctor clamps the clamping groove 2121 of the first sliding part 212 through the clamping jaws 71, applies a force far away from the fixed end 211 to enable each elastic branch to be in an unexpanded and bent state, places the elastic branch into the first placing sleeve 5, reduces the force far away from the fixed end 211 applied to the clamping groove 2121 of the first sliding part 212, slightly expands the self-expanding component, and enables the positioning part 311 of the positioning head 31 to abut against the inner side wall of the first placing sleeve 5; then, the positioning portion 311 of the positioning head 31 is aligned with the positioning groove 32 to make the horizontal heights of the positioning portion and the positioning groove identical, the self-expansion assembly is slowly rotated to make the positioning head 31 of the self-expansion assembly and the positioning groove 32 of the slow release support 1 in an inserting fit, and the sliding head 33 and the sliding groove 34 are in a sliding fit to enter a standby ready-to-release state.

The doctor places the self-expanding medicine slow-release bracket 1 which enters a standby preparation release state into a diseased part of a patient and applies force to the direction of the positioning rod 21 to the inner push rod 72, pushes the self-expanding component 2 and the slow-release bracket 1 partially to be abutted against the affected part, and after finding a proper position, completely pushes the self-expanding component 2 and the slow-release bracket 1 out, the middle part of the slow-release bracket 1 is abutted against the minimum diameter part of the affected part, the first expansion part 24 and the sliding head 33 of the third expansion part 26 move along the sliding groove 34 to be abutted against the baffle 35 under the action of expansion force to form a horn-shaped opening, so that the slow-release bracket 1 is prevented from moving and falling off along the axis; the slow release stent 1 supports the affected part under the acting force of the self-expanding component 2, so that the self-expanding medicine slow release stent 1 mentioned in any embodiment can be conveniently and simply taken and placed at the diseased part of a patient.

The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.

Claims

1. A self-expandable drug-eluting stent (1), characterized in that: comprises a self-expanding stent composition, wherein the self-expanding stent composition comprises a slow release stent (1), a self-expanding assembly (2) and a connecting piece (3); the slow release bracket (1) is provided with symptomatic medicines;

the self-expansion assembly (2) comprises a positioning rod (21), a first elastic piece (22) and a plurality of expansion supporting strips (23), wherein one end of the positioning rod (21) forms a fixed end (211), and the other end of the positioning rod is provided with a first sliding piece (212); two ends of the expansion branch (23) are respectively connected with the fixed end (211) and the first sliding piece (212); the first elastic piece (22) exerts a pulling force on the first sliding piece (212) and drives the first sliding piece (212) to move relatively towards the direction close to the fixed end (211);

connecting piece (3) include a plurality of location head (31) and constant head tank (32), location head (31) are located inflation branch (23) and keep away from the middle part of locating lever (21) one side, constant head tank (32) are located slow-release support (1) week side, location head (31) and constant head tank (32) one-to-one and the cooperation of pegging graft.

2. A self-expanding drug eluting stent (1) according to claim 1, wherein: the positioning rod (21) is further provided with a second sliding piece (213) and a third sliding piece (214), and the second sliding piece (213) and the third sliding piece (214) are sequentially positioned between the first sliding piece (212) and the fixed end (211); the expansion branch bars (23) are provided with three groups along the axial direction of the positioning rod (21), and the expansion branch bars are respectively a first expansion part (24), a second expansion part (25) and a third expansion part (26) from far to near from the fixed end (211);

the first expansion part (24), the second expansion part (25) and the third expansion part (26) respectively comprise at least three expansion branch bars (23) which are uniformly arranged along the circumferential direction of the positioning rod (21);

two ends of each expansion branch (23) in the first expansion part (24) are respectively connected with the first sliding part (212) and the second sliding part (213), two ends of each expansion branch (23) in the second expansion part (25) are respectively connected with the second sliding part (213) and the third sliding part (214), and two ends of each expansion branch (23) in the third expansion part (26) are respectively connected with the third sliding part (214) and the fixed end (211);

the positioning head (31) is positioned in the middle of one side, away from the positioning rod (21), of each expansion branch (23) in the second expansion part (25).

3. A self-expanding drug eluting stent (1) according to claim 2, wherein: the slow-release support is characterized in that sliding grooves (34) are respectively formed in the two axial sides of the positioning groove (32) along the slow-release support (1), sliding heads (33) are respectively arranged in the middle parts of the expansion branch bars (23) in the first expansion part (24) and the third expansion part (26) far away from one side of the positioning rod (21), and the sliding heads (33) are connected with the sliding grooves (34) in a sliding mode.

4. A self-expanding drug eluting stent (1) according to claim 3, wherein: and one end of the sliding groove (34) far away from the positioning groove (32) is respectively provided with a baffle (35).

5. A self-expanding drug eluting stent (1) according to claim 3, wherein: the positioning head (31) comprises a positioning part (311) and a clamping part (312) which are coaxially arranged, the clamping part (312) is fixedly connected with the expansion branch (23), and the positioning part (311) is fixedly connected with the clamping part (312); locating part (311) is kept away from locating lever (21) ascending sectional area along its axis and is reduced in proper order, locating lever (21) ascending sectional area is kept away from along its axis in proper order in joint portion (312), the sectional area of locating part (311) and joint portion (312) junction equals, constant head tank (32) and location head (31) cooperation of pegging graft.

6. A self-expanding drug eluting stent (1) according to claim 5, wherein: the positioning part (311) and the clamping part (312) are evenly provided with a plurality of gaps (313) along the circumferential direction.

7. A self-expanding drug eluting stent (1) according to claim 1, wherein: the slow release stent (1) comprises slow release microtubes (11), and the slow release microtubes (11) are connected in a cross mode to form the slow release stent (1) with a ring-shaped net structure.

8. A self-expanding drug eluting stent (1) according to claim 7, wherein: the periphery of the slow release bracket (1) is provided with a drug slow release layer (4), the drug slow release layer (4) is provided with symptomatic drugs, and the symptomatic drugs comprise one or more of antibacterial drugs, anti-inflammatory drugs, anti-cancer drugs and hemostatic drugs.

9. A self-expanding drug eluting stent (1) according to claim 8, wherein: the interior of the slow release microtube (11) is hollow, slow release or later release medicines are filled in the slow release microtube (11), and slow release micropores (111) are formed in the surface of the slow release microtube (11).

10. A delivery device for use in a self-expanding drug eluting stent (1) as claimed in any one of claims 1-9, wherein: comprises a first placing sleeve (5), wherein the first placing sleeve (5) is hollow inside; a plurality of track grooves (51) are uniformly distributed on the first placing sleeve (5) along the circumferential direction of the first placing sleeve, and the track grooves (51) are formed along the axial direction of the first placing sleeve (5) and correspond to the positioning heads (31) one by one;

a clamping piece (7) is arranged in the first placing sleeve (5), the clamping piece (7) comprises a plurality of clamping jaws (71), an inner push rod (72) and a second elastic piece (73), and an annular clamping groove (2121) is formed in the outer peripheral side of the first sliding piece (212); one end of the clamping jaw (71) is hinged with one end of the inner push rod (72) close to the positioning rod (21), and the other end of the clamping jaw is provided with a butting part which is spliced and matched with the clamping groove (2121); the second elastic piece (73) drives one end of the claw (71) far away from the inner push rod (72) to rotate towards the direction close to the inner push rod (72);

the fixed cover of first casing (5) periphery side of placing is equipped with the second and places casing (6), first casing (5) of placing and second place and form annular between casing (6) and place the cavity of placing.