CN110651187A - 基于c-c基序趋化因子配体14测量结果评价和治疗肾损伤和肾衰竭的方法和组合物 - Google Patents

基于c-c基序趋化因子配体14测量结果评价和治疗肾损伤和肾衰竭的方法和组合物 Download PDF

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Publication number
CN110651187A
CN110651187A CN201880012782.7A CN201880012782A CN110651187A CN 110651187 A CN110651187 A CN 110651187A CN 201880012782 A CN201880012782 A CN 201880012782A CN 110651187 A CN110651187 A CN 110651187A
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aki
subject
persistent
threshold
motif chemokine
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CN201880012782.7A
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Chinese (zh)
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J·P·肯普夫
P·麦克菲森
D·查尔芬
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Smart Medicine Co ltd
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Smart Medicine Co ltd
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Priority to CN202111365747.3A priority Critical patent/CN114088950A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/521—Chemokines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN201880012782.7A 2017-01-12 2018-01-12 基于c-c基序趋化因子配体14测量结果评价和治疗肾损伤和肾衰竭的方法和组合物 Pending CN110651187A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111365747.3A CN114088950A (zh) 2017-01-12 2018-01-12 基于c-c基序趋化因子配体14测量结果评价和治疗肾损伤和肾衰竭的方法和组合物

Applications Claiming Priority (3)

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US201762445692P 2017-01-12 2017-01-12
US62/445,692 2017-01-12
PCT/US2018/013561 WO2018132702A1 (en) 2017-01-12 2018-01-12 Methods and compositions for evaluation and treatment of renal injury and renal failure based on c-c motif chemokine ligand 14 measurement

Related Child Applications (1)

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CN202111365747.3A Division CN114088950A (zh) 2017-01-12 2018-01-12 基于c-c基序趋化因子配体14测量结果评价和治疗肾损伤和肾衰竭的方法和组合物

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CN110651187A true CN110651187A (zh) 2020-01-03

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CN201880012782.7A Pending CN110651187A (zh) 2017-01-12 2018-01-12 基于c-c基序趋化因子配体14测量结果评价和治疗肾损伤和肾衰竭的方法和组合物
CN202111365747.3A Pending CN114088950A (zh) 2017-01-12 2018-01-12 基于c-c基序趋化因子配体14测量结果评价和治疗肾损伤和肾衰竭的方法和组合物

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US (2) US11353465B2 (https=)
EP (2) EP4063853A1 (https=)
JP (2) JP2020504157A (https=)
CN (2) CN110651187A (https=)
AU (1) AU2018207151B2 (https=)
CA (1) CA3049444A1 (https=)
MX (1) MX2019008260A (https=)
WO (1) WO2018132702A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4063853A1 (en) 2017-01-12 2022-09-28 Astute Medical, Inc. Methods and compositions for evaluation and treatment of renal injury and renal failure based on c-c motif chemokine ligand 14 measurement
US11891439B2 (en) 2017-12-28 2024-02-06 Astute Medical, Inc. Antibodies and assays for CCL14
CN114207436A (zh) * 2019-05-24 2022-03-18 机敏医药股份有限公司 基于c-c基序趋化因子配体14测量而评估和治疗肾损伤的方法
CA3145667A1 (en) * 2019-07-02 2021-01-07 Astute Medical, Inc Antibodies and assays for ccl14
EP4247395A4 (en) * 2020-11-18 2024-09-18 Astute Medical, Inc. Methods and compositions for treatment of renal injury and renal failure
CN113555122B (zh) * 2021-07-21 2024-04-26 中南大学湘雅二医院 一种重症脓毒症患者一过性和持续性aki的预测模型及其构建方法
CA3253529A1 (en) * 2022-03-03 2023-09-07 Astute Medical, Inc. METHODS AND COMPOSITIONS FOR EVALUATING AND TREATING PERSISTENT ACUTE RENAL INJURY BASED ON A C-C MOTIFYING CHEMOKIN LIGAND MEASUREMENT 14

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102187219A (zh) * 2008-08-29 2011-09-14 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
EP2479566A2 (en) * 2007-03-26 2012-07-25 Novartis AG Predictive renal safety biomarkers and biomarker signatures to monitor kidney function
CN102725636A (zh) * 2009-12-20 2012-10-10 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
WO2016064877A2 (en) * 2014-10-20 2016-04-28 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US5939272A (en) 1989-01-10 1999-08-17 Biosite Diagnostics Incorporated Non-competitive threshold ligand-receptor assays
US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
CA2072758A1 (en) 1990-09-14 1992-03-15 Kenneth Francis Buechler Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays
US5955377A (en) 1991-02-11 1999-09-21 Biostar, Inc. Methods and kits for the amplification of thin film based assays
AU1772992A (en) 1991-04-10 1992-11-17 Biosite Diagnostics Incorporated Crosstalk inhibitors and their uses
JP3290988B2 (ja) 1991-04-11 2002-06-10 バイオサイト・ダイアグノスティックス・インコーポレイテッド 多重リガンドを同時検出する新規接合体及び検定法
US5885527A (en) 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
US6143576A (en) 1992-05-21 2000-11-07 Biosite Diagnostics, Inc. Non-porous diagnostic devices for the controlled movement of reagents
US5494829A (en) 1992-07-31 1996-02-27 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US5824799A (en) 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
US6811773B1 (en) * 1993-12-22 2004-11-02 Human Genome Sciences, Inc. Human monocyte colony inhibitory factor (M-CIF) polypeptides
US6113855A (en) 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
US5947124A (en) 1997-03-11 1999-09-07 Biosite Diagnostics Incorporated Diagnostic for determining the time of a heart attack
US6057098A (en) 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
AU2003223172A1 (en) 2002-02-12 2003-09-04 Quark Biotech, Inc. Use of the axl receptor for diagnosis and treatment of renal disease
EP1915614A4 (en) * 2005-07-21 2009-03-25 Univ Johns Hopkins METHOD FOR DETECTING AND TREATING AN ACUTE KIDNEY INJURY
US20110059537A1 (en) * 2007-09-20 2011-03-10 Caritas St. Elizabeth's Medical Center Of Boston, Inc. Method for estimating risk of acute kidney injury
CA2740923A1 (en) 2008-10-21 2010-04-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2462437A4 (en) 2009-08-07 2013-01-30 Rules Based Medicine Inc METHOD AND DEVICES FOR DETECTING DIABETIC NEPHROPATHY AND ASSOCIATED DISEASES THEREOF
NZ600160A (en) 2009-11-07 2014-05-30 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20120156701A1 (en) 2009-12-20 2012-06-21 Joseph Anderberg Methods and compositions for diagnosis and prognosis of renal injury and renal failure
AU2011213684B2 (en) 2010-02-05 2014-11-20 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ606124A (en) 2010-06-23 2015-05-29 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
IN2012MN02812A (https=) 2010-06-23 2015-05-22 Astute Medical Inc
NZ605698A (en) 2010-06-23 2015-03-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2012136548A1 (en) 2011-04-04 2012-10-11 Universiteit Gent Biomarkers for acute kidney injury
PT2748605T (pt) 2011-08-26 2019-05-03 Astute Medical Inc Processos e composições para o diagnóstico e o prognóstico de lesões renais e de insuficiência renal
US10935548B2 (en) 2011-12-08 2021-03-02 Astute Medical, Inc. Methods for diagnosis and prognosis of renal injury and renal failure using insulin-like growth factor-binding protein 7 and metalloproteinase inhibitor 2
WO2013096740A1 (en) 2011-12-21 2013-06-27 Alere San Diego Inc. Methods and compositions for assigning likelihood of chronic kidney disease progression
EP4063853A1 (en) 2017-01-12 2022-09-28 Astute Medical, Inc. Methods and compositions for evaluation and treatment of renal injury and renal failure based on c-c motif chemokine ligand 14 measurement

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2479566A2 (en) * 2007-03-26 2012-07-25 Novartis AG Predictive renal safety biomarkers and biomarker signatures to monitor kidney function
CN102187219A (zh) * 2008-08-29 2011-09-14 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
CN102725636A (zh) * 2009-12-20 2012-10-10 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
CN104698161A (zh) * 2009-12-20 2015-06-10 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
WO2016064877A2 (en) * 2014-10-20 2016-04-28 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KYLE J. GUNNERSON 等: "TIMP2•IGFBP7 biomarker panel accurately predicts acute kidney injury in high-risk surgical patients", 《THE JOURNAL OF TRAUMA》 *
钱家麟: "《难治性泌尿系统疾病》", 31 December 2007, 上海科学技术出版社 *

Also Published As

Publication number Publication date
AU2018207151A1 (en) 2019-07-18
CA3049444A1 (en) 2018-07-19
WO2018132702A1 (en) 2018-07-19
JP2020504157A (ja) 2020-02-06
EP4063853A1 (en) 2022-09-28
AU2018207151B2 (en) 2024-02-29
JP2022091846A (ja) 2022-06-21
EP3568695A1 (en) 2019-11-20
MX2019008260A (es) 2020-01-27
US20190339289A1 (en) 2019-11-07
US20230025225A1 (en) 2023-01-26
CN114088950A (zh) 2022-02-25
US11353465B2 (en) 2022-06-07
EP3568695A4 (en) 2020-12-16
US12203944B2 (en) 2025-01-21

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