CN110646274B - Disposable intraoperative frozen pathological tissue sampling and collecting device and application thereof - Google Patents
Disposable intraoperative frozen pathological tissue sampling and collecting device and application thereof Download PDFInfo
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- 230000001575 pathological effect Effects 0.000 title claims abstract description 71
- 238000005070 sampling Methods 0.000 title claims abstract description 17
- 239000000463 material Substances 0.000 claims abstract description 50
- 238000010257 thawing Methods 0.000 claims abstract description 47
- 238000001035 drying Methods 0.000 claims abstract description 25
- 238000007710 freezing Methods 0.000 claims abstract description 20
- 238000010438 heat treatment Methods 0.000 claims abstract description 20
- 230000008014 freezing Effects 0.000 claims abstract description 19
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- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
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- 239000003755 preservative agent Substances 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/42—Low-temperature sample treatment, e.g. cryofixation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
- G01N2001/362—Embedding or analogous mounting of samples using continuous plastic film to mount sample
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Abstract
The invention belongs to the technical field of pathological tissue sampling auxiliary devices, and particularly relates to a disposable intraoperative frozen pathological tissue collecting and sampling device and application thereof. The device comprises: the device comprises a bottom plate, a fixing frame, a rolling shaft, a flexible film, a binding component, a freezing and melting zone, a drying zone, a tissue placing groove, a slot, a water outlet pipe and the like; one end of the bottom plate is provided with two groups of fixing frames, the rolling shaft is arranged between the two groups of fixing frames, and the rolling shaft can rotate by taking the fixing frames as fulcrums; the flexible film is wound on the roller; the binding component is arranged on the bottom plate; the other end of the bottom plate is provided with a freezing and melting zone and a drying zone, wherein a heating device is arranged in the freezing and melting zone and the drying zone; the freeze thawing area is provided with a tissue placing groove; the drying area is provided with a slot; the water outlet pipe is communicated with the tissue thawing groove. The device has the characteristics of reliability, high efficiency and convenient use, and can well solve the clinical pathological problem of the timeliness and accuracy of rapid freezing pathological material drawing, specimen collection and freeze thawing in the prior art.
Description
Technical Field
The invention belongs to the technical field of pathological tissue sampling auxiliary devices, and particularly relates to a disposable intraoperative frozen pathological tissue collecting and sampling device and application thereof.
Background
The information disclosed in this background of the invention is only for enhancement of understanding of the general background of the invention and is not necessarily to be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person skilled in the art.
The quick freezing pathology in the operation is that after a fresh tissue sample to be examined is taken, sliced and stained, a pathologist conducts diagnosis in the operation to guide the quick diagnosis of the pathology in the excision range of the operation, a pathological diagnosis report is required to be provided within 30 minutes of the sample to be examined, and the timeliness and the accuracy of the pathological diagnosis report directly relate to the operation range and the treatment prognosis of a patient. Therefore, improving the optimization of the intraoperative rapid pathological material taking process plays an important role in accurate diagnosis of pathology.
In recent years, the number of specimens to be examined for rapid intraoperative pathological diagnosis has been increasing year by year, and the types of specimens have become more complicated. The inventor finds that:
(1) before each pathological specimen is taken, a lot of time is consumed for washing and drying a material taking plate, so that the timeliness of the rapid pathology in the operation is hindered; because the fresh tissue has larger water content, when the material taking knife or the material taking plate has water during material taking, a great amount of ice crystals appear in cell nucleuses and cytoplasm of the tissue during the freezing process, and the observation and accurate pathological diagnosis of doctors are influenced.
(2) Moreover, tumor tissues of some smaller lesions trimmed in the process of material drawing are usually washed away or ignored, and pathological diagnosis of the final paraffin section after operation is also influenced; tissue contamination may occur between different pathological specimens.
(3) After the tissue section is finished, a long time is needed for placing the tissue section in the embedding box after the tissue section is frozen and thawed from the specimen tray, the tissue section is easy to mix when the quantity of the specimens is large, and the timeliness of quick freezing in the operation is also seriously influenced.
Disclosure of Invention
Aiming at the problems, the invention considers that whether a material taking plate of a device which is free of washing and tissue loss and can accelerate freeze thawing can be designed, and becomes a key for solving the clinical pathological problems of rapid freezing pathological material taking, specimen collection and freeze thawing timeliness and accuracy in the prior art. Therefore, the invention provides a disposable intraoperative frozen pathological tissue collecting and taking device and application thereof. The device of the invention has the characteristics of reliability, high efficiency and convenient use, and can well solve the problems.
The first object of the present invention: provides a one-off intraoperative frozen pathological tissue sampling and collecting device.
The second object of the present invention: provides the application of the device for collecting and taking the frozen pathological tissues in the disposable operation.
In order to realize the purpose, the invention discloses the following technical scheme:
firstly, the invention discloses a disposable intraoperative frozen pathological tissue collecting and drawing device, which comprises: the device comprises a bottom plate, a fixing frame, a rolling shaft, a flexible film, a binding component, a freezing and thawing zone, a drying zone, a tissue placing groove, a slot, a temperature control knob, a plug and a water outlet pipe; wherein:
one end of the bottom plate is provided with two groups of fixing frames, the rolling shaft is arranged between the two groups of fixing frames, the rolling shaft is parallel to the upper surface of the bottom plate, and the rolling shaft can rotate by taking the fixing frames as fulcrums; the flexible film is wound on a roller.
The binding component is arranged on the bottom plate and used for fixing the flexible film paved on the surface of the bottom plate; the other end of the bottom plate is a thawing zone of frozen pathological tissues, which is divided into a thawing zone and a drying zone, and heating devices are arranged in the thawing zone and the drying zone.
The freezing and thawing area is provided with a tissue placing groove for placing the frozen pathological tissue support so as to thaw the frozen pathological tissue support under the heating of the heating device; the drying area is provided with a slot; the temperature control knob is arranged in the defrosting area, is connected with the heating device and is used for controlling the on-off of the heating device and adjusting the temperature of the heating device; the plug is connected with the temperature control knob through a lead; the water outlet pipe is communicated with the tissue thawing groove.
As a further technical scheme, an easy-to-tear line is arranged on the flexible film and is parallel to the axis of the roller; so that the flexible film can be cut off through the easy-to-tear line after the length of the flexible film paved on the surface of the bottom plate meets the requirement.
As a further technical scheme, the two side edge positions of the flexible film are provided with adhesive areas, the adhesive areas face upwards after the flexible film is laid on the bottom plate, and the two side edge positions refer to areas where the two ends of the rolling shaft are located. After the flexible film is laid, the adhesive area faces upwards and is perpendicular to the axis of the rolling shaft.
As a further technical solution, the size of the bottom plate is: the length is 50-65cm, the width is 35-45cm, and optionally, the bottom plate is made of hard plastic or wood.
As a further technical solution, the flexible film is made of plastic material, for example, can be made of plastic wrap, the thickness of the flexible film is based on the suitability for cutting pathological tissues, and the "suitability for cutting" means that the flexible film does not break after the pathological tissues are cut.
As a further technical scheme, be provided with semi-closed annular groove on one face of flexible membrane, correspondingly, still be provided with on the flexible membrane and be provided with semi-closed annular arch with this recess, annular groove and annular arch are the axisymmetric setting, follow this symmetry axis with the folding flexible membrane, the annular arch can the block make flexible membrane form the sealing bag in the annular groove, be convenient for quick and complete collection pathological tissue sample after drawing materials. Correspondingly, the back of the face where the annular groove is located on the flexible film is provided with the sand grip, be provided with on the upper surface of bottom plate with the concave groove that the sand grip matches to in fixing the flexible film on the bottom plate, at this moment, can omit bind the part, through the cooperation of sand grip and concave groove, make the flexible film can quick fix, again can open fast.
As a further technical scheme, the binding component comprises a rubber band, a thread gluing and the like.
As a further technical scheme, the width of the thawing zone is 15-25 cm.
As a further technical scheme, the temperature control range of the heating device is 40-60 ℃. The heating device can rapidly heat the pathological tissues in the tissue thawing groove without damaging the tissues, greatly improves the thawing efficiency of the pathological tissues and shortens the time for recovering frozen pathological tissue blocks; meanwhile, the material taking tool can be inserted into the drying hole for standby after being washed, so that the influence of excessive moisture on the formation of ice crystals in the tissue flaking process is further prevented.
As a further technical scheme, the number of the tissue thawing grooves is 6-12.
Finally, the invention discloses the application of the device for collecting and taking frozen pathological tissues in the disposable operation in the fields of medical treatment, biology and the like.
Compared with the prior art, the invention has the following beneficial effects:
(1) the device has the characteristics of reliability, high efficiency and convenient use, and can well solve the clinical pathological problem of the timeliness and accuracy of rapid freezing pathological material drawing, specimen collection and freeze thawing in the prior art.
(2) The invention can shorten the time of a plurality of processes of material taking, table surface washing, frozen tissue thawing, instrument drying, specimen collection and the like, and greatly improves the intraoperative rapid efficiency; particularly, the influence of tissue ice crystals on diagnosis caused by excessive water content caused by flushing a table top and instruments is avoided, and the problem of pollution among different tissues is further avoided.
(3) The flexible membrane can enable the tissues to be directly sealed in the specimen bag after the materials are taken, and the tissue specimens are not additionally transferred, so that the time for putting the tissue specimens one by one is saved, and the small tissue specimens are prevented from being lost; and the flexible membrane can be used as a disposable sampling plate surface, so that the time for repeatedly washing the table top and wiping the table top before sampling the next sample after sampling the sample is saved, and the sampling efficiency is improved.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate exemplary embodiments of the invention and together with the description serve to explain the invention and not to limit the invention.
Fig. 1 is a schematic structural view of a device for collecting and sampling frozen pathological tissues in a disposable operation in embodiment 1.
Fig. 2 is a schematic structural view of a flexible film in example 2.
Fig. 3 is a schematic structural view of a flexible film in example 4.
Fig. 4 is a schematic structural view of a base plate and a flexible film in example 4.
The designations in the above figures represent respectively: 1-bottom plate, 2-fixing frame, 3-rolling shaft, 4-flexible film, 5-binding component, 6-freezing and melting zone, 7-drying zone, 8-tissue placing groove, 9-slot, 10-temperature control knob, 11-plug, 12-water outlet pipe, 13-sticking zone and 14-easy-tearing line.
Detailed Description
It is to be understood that the following detailed description is exemplary and is intended to provide further explanation of the invention as claimed. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the invention. As used herein, the singular forms also are intended to include the plural forms as well, unless the context clearly indicates otherwise, and it should be further understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of the stated features, steps, operations, devices, components, and/or combinations thereof.
As mentioned above, the rapid freezing pathology in the operation is that after the fresh tissue to be examined is sliced and stained, a pathologist conducts diagnosis in the operation to guide the rapid pathology diagnosis of the surgical excision range, and a pathological diagnosis report is required to be sent out within 30 minutes of the specimen to be examined, so that improvement of optimization of the rapid pathology drawing process in the operation plays an important role in accurate diagnosis of the pathology. Therefore, the invention provides a disposable intraoperative frozen pathological tissue collecting and taking device and application thereof; the invention will now be further described with reference to the accompanying drawings and detailed description.
Example 1
Referring to fig. 1, a disposable intraoperative frozen pathological tissue collecting and taking device mainly comprises: the device comprises a bottom plate 1, a fixing frame 2, a rolling shaft 3, a flexible film 4, a binding component 5, a freezing and thawing zone 6, a drying zone 7, a tissue placing groove 8, a slot 9, a temperature control knob 10, a plug 11 and a water outlet pipe 12; wherein:
one end of the bottom plate 1 is provided with two groups of fixing frames 2, the rolling shaft 3 is arranged between the two groups of fixing frames 2, the rolling shaft 3 is parallel to the upper surface of the bottom plate 1, and the rolling shaft 3 can rotate by taking the fixing frames as fulcrums; the flexible membrane 4 is wound on the roller 3, so that the flexible membrane is firstly paved on the upper surface of the bottom plate 1 before pathological tissue taking.
The binding component 5 is arranged on the bottom plate 1 and is used for fixing the flexible film paved on the surface of the bottom plate 1; the other end of the bottom plate 1 is a thawing zone of frozen pathological tissues, which is divided into a thawing zone 6 and a drying zone 7, and heating devices are arranged in the thawing zone 6 and the drying zone 7 so as to provide energy for thawing and drying the frozen pathological tissues.
The freezing and thawing area 6 is provided with a tissue placing groove 8 for placing frozen pathological tissues to thaw the frozen pathological tissues under the heating of the heating device; drying area 7 is provided with slot 9 to the instrument of pathological tissue drawing materials needs is placed in the convenience, if the sword of drawing materials is cut, tweezers etc. simultaneously, owing to need wash the instrument of drawing materials before drawing materials, consequently, set up slot 9 in drying area and can dry the instrument of drawing materials, further prevent the influence of moisture on the instrument of drawing materials to tissue film-making process formation ice crystal.
The temperature control knob 10 is arranged in the defrosting area, is connected with the heating device and is used for controlling the on-off of the heating device and adjusting the temperature of the heating device; the plug 11 is connected with the temperature control knob 10 through a lead; the outlet pipe 12 and the tissue thawing groove 8 are communicated, so that liquid after the frozen pathological tissues are thawed is discharged from the tissue thawing groove 8, meanwhile, the discharging of cleaning liquid is facilitated when the tissue thawing groove 8 is cleaned, and the whole device is not required to be inverted for discharging the cleaning liquid.
Example 2
A disposable intraoperative frozen pathological tissue collecting and taking device is the same as the device in the embodiment 1, and is characterized in that: referring to fig. 2, the flexible film 4 is provided with a tear line 14, and the tear line 14 is parallel to the axis of the roller 3; after the length of the flexible film paved on the surface of the bottom plate 1 meets the requirement, the flexible film can be cut off through the easy-to-tear line 14; meanwhile, the flexible membrane can be used as a disposable material taking plate surface, so that the time for repeatedly washing the table top and wiping the table top before taking the next sample after each time of material taking is saved, and the material taking efficiency is improved; meanwhile, the problem of pollution among different specimens can be effectively prevented, the specimens are convenient to take and use, the method is efficient and quick, and the pathological diagnosis report can be sent out within 30 minutes after the specimens are submitted for inspection.
Referring to fig. 2, the two side edges of the flexible film 4 are provided with adhesive areas 13, and the adhesive areas 13 face upward after the flexible film 4 is laid on the bottom plate 1, and the two side edges refer to areas where the two ends of the roller 3 are located. After the flexible film is laid, the adhesive area 13 faces upwards, the adhesive area is perpendicular to the axis of the roller 3, pathological tissues are placed on the flexible film for taking materials, after the materials are taken, the flexible film is folded in half along the length direction of the adhesive area (in a self-sealing strip form) and then the adhesive areas at the edges of the flexible film 4 are bonded together, the flexible film forms a three-edge closed bag-shaped structure (a specimen bag) with one edge open, and then one edge of the opening can be closed again through other modes such as adhesion and the like, so that the pathological tissues after the materials are taken are closed and collected.
Example 3
A disposable intraoperative frozen pathological tissue collecting and taking device is the same as the device in the embodiment 1, and is characterized in that: the dimensions of the base plate 1 are: the length is 50-65cm, the width is 35-45cm, the bottom plate is made of hard plastic, and the freezing and melting zone and the drying zone are made of stainless steel.
Example 4
A disposable intraoperative frozen pathological tissue collecting and taking device is the same as the device in the embodiment 1, and is characterized in that: referring to fig. 3 and 4, a semi-closed annular groove 15 is formed in one surface of the flexible film 4, correspondingly, a semi-closed annular protrusion 16 is formed in the flexible film 4 and is arranged in the groove 15, the annular groove 15 and the annular protrusion 16 are arranged in an axisymmetric manner, and after the flexible film is folded along the symmetry axis, the annular protrusion 16 can be clamped in the annular groove 15 to form a sealing bag for the flexible film, so that the collection of the pathological tissue specimen after material drawing can be rapidly and completely performed. Correspondingly, the back of the surface of the flexible film where the annular groove 15 is located is provided with a convex strip 17, the upper surface of the base plate 1 is provided with a concave groove 18 matched with the convex strip 17, so as to fix the flexible film on the base plate 1, it should be understood that, at this time, the flexible film can still be fixed on the base plate 1 after the binding component 5 is omitted, that is, the binding component 5 is replaced by the convex strip 17 and the concave groove 18, so that the flexible film can be quickly fixed and can be quickly opened.
Example 5
A disposable intraoperative frozen pathological tissue collecting and taking device is the same as the device in the embodiment 1, and is characterized in that: the flexible film is made of a preservative film material, the thickness of the flexible film is based on the condition that the flexible film is suitable for cutting pathological tissues, and the condition that the flexible film is not broken after the pathological tissues are cut is adopted as the condition that the flexible film is suitable for cutting.
Example 6
A disposable intraoperative frozen pathological tissue collecting and taking device is the same as the device in the embodiment 1, and is characterized in that: the binding component comprises a rubber band; the width of the thawing zone is 15 cm; the number of the tissue thawing grooves 8 is 6.
Example 7
A disposable intraoperative frozen pathological tissue collecting and taking device is the same as the device in the embodiment 1, and is characterized in that: the binding component comprises a rubber band; the width of the thawing zone is 25 cm; the number of the tissue thawing grooves 8 is 12.
Example 8
A disposable intraoperative frozen pathological tissue collecting and taking device is the same as the device in the embodiment 1, and is characterized in that: the temperature control range of the heating device is 40-60 ℃. The heating device can rapidly heat the pathological tissues in the tissue thawing groove 8 without damaging the tissues, greatly improves the thawing efficiency of the pathological tissues and shortens the time for recovering frozen pathological tissue blocks; meanwhile, the material taking tool can be inserted into the drying hole for standby after being washed, so that the influence of excessive moisture on the formation of ice crystals in the tissue flaking process is further prevented.
Example 9
In this embodiment, frozen pathological material sampling in breast cancer surgery is taken as an example to illustrate the using method of the material sampling device of the present invention and the advantages of the material sampling device compared with the traditional material sampling method.
The traditional material taking method is that a material taking plate is washed, wiped dry by gauze and dried as far as possible, the material is washed repeatedly after being taken, mutual pollution is caused due to incomplete washing, tissues are placed into a sample fixing bag one by one after the sample is taken, and the samples on a tissue support are waited to be slowly melted at the same time.
The one-off intraoperative frozen pathological tissue collecting and taking device designed by the invention can well solve the problems in the links. Firstly, a power supply is switched on to heat a thawing area for later use, then the flexible film 4 fixed on the roller 3 is pulled, the flexible film with the area as large as that of the bottom plate 1 is selected, and then the flexible film is torn from the easy-to-tear line to be used as a disposable material taking plate surface; fixing the flexible film with the bottom plate 1 by using a binding device 5; cutting a representative tissue on the disposable material taking plate surface, placing the tissue into a freezing microtome for sectioning, taking down the disposable material taking plate surface, folding the disposable material taking plate surface along the length direction of the adhesive area to obtain a specimen bag, and directly placing all tissue specimens in the specimen bag without additionally transferring the tissue specimens; after the preparation, the tissue specimen after the preparation is placed in a tissue thawing groove 8, the tissue thawing can be realized quickly due to higher temperature and heat conduction, and meanwhile, instruments such as a knife, a scissor and a forceps which are used for taking materials at this time are cleaned and then placed in a slot 9 for drying and standby; the invention can effectively improve the material taking efficiency, prevent pollution and well solve the clinical pathological problem of timeliness and accuracy of rapid freezing pathological material taking, specimen collection and freeze thawing in the prior art.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (11)
1. A disposable intraoperative frozen pathological tissue collection and material drawing device is characterized by comprising: the device comprises a bottom plate, a fixing frame, a rolling shaft, a flexible membrane, a freezing and thawing zone, a drying zone, a tissue placing groove, a slot, a temperature control knob, a plug and a water outlet pipe; one end of the bottom plate is provided with two groups of fixing frames, the rolling shaft is arranged between the two groups of fixing frames, the rolling shaft is parallel to the upper surface of the bottom plate, and the rolling shaft can rotate by taking the fixing frames as fulcrums; the flexible film is wound on a rolling shaft; the other end of the bottom plate is a thawing area for freezing pathological tissues, which is divided into a thawing area and a drying area, and heating devices are arranged in the thawing area and the drying area; the freeze thawing area is provided with a tissue placing groove; the drying area is provided with a slot; the temperature control knob is arranged in the defrosting area and is connected with the heating device; the plug is connected with the temperature control knob through a lead; the water outlet pipe is communicated with the tissue thawing groove;
be provided with semi-closed annular groove on one face of flexible membrane, correspondingly, still be provided with on the flexible membrane and be provided with semi-closed annular arch with this recess, annular groove and annular arch set up for the axial symmetry, follow this symmetry axis with the folding back of flexible membrane, the annular arch can the block make flexible membrane formation sealing bag in the annular groove, correspondingly, the back of annular groove place face on the flexible membrane is provided with the sand grip, be provided with on the upper surface of bottom plate with the concave groove that the sand grip matches to fix the flexible membrane on the bottom plate.
2. The device as claimed in claim 1, wherein the flexible film is provided with a tear line parallel to the axis of the roller.
3. A disposable intraoperative frozen pathological tissue collection and harvest device according to any one of claims 1-2, wherein the base plate is sized to: the length is 50-65cm, and the width is 35-45 cm.
4. A disposable intraoperative frozen pathological tissue collection and sampling device according to any one of claims 1-2, wherein the base plate is made of hard plastic or wood.
5. A disposable intraoperative frozen pathological tissue collection and retrieval device according to any one of claims 1-2, wherein the flexible membrane is of plastic material.
6. The disposable intraoperative frozen pathological tissue collection and material drawing device of any one of claims 1-2, wherein the flexible membrane is made of a plastic wrap material.
7. A disposable intraoperative frozen pathological tissue collection and material taking device according to any one of claims 1-2, wherein the thickness of the flexible membrane is based on the suitability for cutting pathological tissues, and the "suitability for cutting" means that the flexible membrane does not break after pathological tissues are cut.
8. A disposable intraoperative frozen pathological tissue collection and harvest device according to any one of claims 1-2, wherein the width of the thawing zone is 15-25 cm.
9. A disposable intraoperative frozen pathological tissue collection and material drawing device according to any one of claims 1-2, characterized in that the temperature control range of the heating device is 40-60 ℃.
10. A disposable intraoperative frozen pathological tissue collection and extraction device according to any one of claims 1-2, characterized in that the number of tissue thawing grooves is 6-12.
11. Use of a disposable intraoperative frozen pathological tissue collection and harvest device according to any one of claims 1 to 10 in the medical and biological fields.
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| CN201910881161.9A CN110646274B (en) | 2019-09-18 | 2019-09-18 | Disposable intraoperative frozen pathological tissue sampling and collecting device and application thereof |
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| CN201910881161.9A CN110646274B (en) | 2019-09-18 | 2019-09-18 | Disposable intraoperative frozen pathological tissue sampling and collecting device and application thereof |
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| CN110646274B true CN110646274B (en) | 2022-04-22 |
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