CN110639099A - Cell suspension atomizing device - Google Patents
Cell suspension atomizing device Download PDFInfo
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- CN110639099A CN110639099A CN201910934672.2A CN201910934672A CN110639099A CN 110639099 A CN110639099 A CN 110639099A CN 201910934672 A CN201910934672 A CN 201910934672A CN 110639099 A CN110639099 A CN 110639099A
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- 239000006285 cell suspension Substances 0.000 title claims abstract description 34
- 239000000725 suspension Substances 0.000 claims abstract description 47
- 238000000889 atomisation Methods 0.000 claims abstract description 41
- 238000005507 spraying Methods 0.000 claims abstract description 18
- 239000007921 spray Substances 0.000 claims description 40
- 238000002347 injection Methods 0.000 claims description 22
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
Abstract
The invention provides a cell suspension atomization device, which enables a supply part to form high-speed airflow due to pressure through controlling mechanical drive or air pressure drive by an electric control part, so that very high relative speed is formed between gas and cell suspension, a liquid column or a liquid film is damaged, the flowing property, apparent viscosity and surface tension of liquid are changed, and meanwhile, the liquid part of a continuous phase is changed into dispersibility to achieve the atomization effect; the device improves the activity rate of cells in the suspension atomization process and the uniform distribution on the spraying surface, shortens the re-epithelialization period and reduces the treatment cost. In addition, the device controls the mechanical driving part or the pneumatic driving part through the electric control part to drive the fog drops formed by the supply part to be attached to the target spraying area on the skin in a gentle mode, and no stimulation is caused.
Description
Technical Field
The invention relates to the field of biomedical devices, in particular to a cell suspension atomization device in the treatment of large-area deep second-degree burn skin.
Background
The large-area skin wound is closely related to various emergencies and serious diseases and is a common clinical disease, and the life quality of a patient is seriously reduced and even the life is threatened due to the characteristic of delayed healing. When deep skin wounds or extensive skin burns occur, a series of serious complications may be caused, such as sepsis due to bacterial infection, shock due to insufficient blood volume, or tissue contraction due to improper healing of wounds, etc. Extensive burns of the skin also lead to death of skin cells and loss of large amounts of body fluids, with subsequent dehydration, electrolyte disturbance, and subsequent failure of the kidneys and circulatory system. Skin damaged by burns is extremely susceptible to bacteria and other pathogens, and complications from infection can cause patients to feel severely uncomfortable or even lose life. At present, the treatment and repair method for large-area skin burn mainly adopts the fault skin graft transplantation, the particle skin transplantation technology, the skin graft mixed transplantation and the like based on autologous skin transplantation. However, the method based on the autologous skin transplantation generally needs a patient to provide a large amount of autologous skin sources, the ratio of the burn area to the autologous skin source area is about 3:1 clinically, the ratio of scientific research is only 9:1 at the highest, but patients with large-area skin injury are lack of skin sources, skin supply area injury can be caused by large-area skin taking, severe scars can be remained after wound healing, and the like. In addition, the re-epithelialization period of the method is long, the pain time of patients is long, the hospitalization nursing cost is high, and the problems of scar hyperplasia, shrinkage, even dysfunction and the like generally occur after the wound surface is healed. Therefore, it is very important to shorten the healing time, improve the functional repair of the skin and limit the formation of scars by the early non-surgical intervention of burn wounds.
Disclosure of Invention
In order to overcome the deficiencies of the prior art, the present invention provides a cell suspension aerosolization apparatus. The electric control part controls the driving part to drive the supply part to realize the atomization effect of the cell suspension, the activity rate of the cells in the suspension atomization process is improved, the uniform distribution of the cells on the spraying surface is realized, and the re-epithelialization period is shortened.
The invention provides a cell suspension atomization device, which comprises an atomization device body, wherein the atomization device body comprises a cell supply assembly, a feedback assembly and a control assembly, and the control assembly is connected with the cell supply assembly and the feedback assembly; wherein the content of the first and second substances,
the control assembly comprises an electrical control part and a data acquisition part, and the electrical control part is electrically connected with the data acquisition part; the data acquisition part is used for receiving the data acquired by the feedback assembly, and the data acquisition part sends the acquired data to the electrical control part;
the cell supply assembly comprises a driving part and a supply part, the driving part is connected with the electric control part, the supply part is connected with the data acquisition part, and the electric control part adjusts the driving part according to the data acquired by the data acquisition part, so that the driving part drives the supply part to atomize and spray the suspension inside the supply part to a target spraying area on the skin.
Preferably, the driving part comprises a mechanical driving part, the mechanical driving part comprises a motor, a linear driver and a push rod, the motor is electrically connected with the electric control part, and the linear driver is connected with the motor and the push rod; the feedback assembly comprises a position sensor, the position sensor collects the position of the supply part and feeds collected data back to the data collection part, the electric control part adjusts the motor to drive the linear driver to move along one direction according to the data fed back by the data collection part, so that the push rod drives the supply part to atomize and spray suspension inside the supply part to a target spraying area on the skin.
Preferably, the supply part comprises a mechanical supply part, the mechanical supply part comprises an injection part, a clamping block and a joint, the injection part is connected with the push rod, the push rod is used for sucking or discharging the suspension into or out of the interior of the injection part, the injection part is fixedly arranged on the clamping block, and the joint is fixedly arranged at one end of the injection part and is used for connecting a suspension spray pipe.
Preferably, the driving part includes a pneumatic driving circuit, the pneumatic driving circuit includes an air pump, an electrical control valve, an air storage tank and a two-way valve, the air pump delivers air into the air storage tank, the feedback assembly includes a first pressure sensor, the first pressure sensor is used for collecting the pressure of the air in the air storage tank and feeding back the collected data to the data collection part, the electrical control valve and the two-way valve are electrically connected to the electrical control part, and the electrical control part adjusts the electrical control valve according to the feedback data of the data collection part, so that the pneumatic driving supply part atomizes and sprays the suspension inside the supply part to the target area to be sprayed on the skin.
Preferably, the supply part comprises a pneumatic supply part, the pneumatic supply part comprises a sealed tank and an atomizing spray gun, and the electric control part adjusts the electric control valve to convey the driving gas in the gas storage tank into the sealed tank, so that the suspension in the sealed tank is sprayed to the target spraying area on the skin through the atomizing spray gun under the action of the pneumatic pressure.
Preferably, the air pressure driving circuit further comprises a second pressure sensor, and the second pressure sensor is used for collecting air pressure data output from the air storage tank and feeding back the data to the data collecting part.
Preferably, the pneumatic driving circuit further comprises a filter element, the filter element is connected with the seal tank, and the filter element is used for filtering airflow entering the seal tank.
Preferably, the air pressure supply part further comprises an orifice, the orifice is arranged between the seal pot and the atomizing spray gun, and the orifice is used for enabling the atomizing spray gun to output suspension with constant flow.
Preferably, the atomization spray gun comprises a suspension spray pipe and a filter, the filter is installed at one end of the suspension spray pipe and is used for filtering the suspension before entering the suspension spray pipe, and the aperture of a filter hole of the filter is 0.2-0.5 times of the inner diameter of the suspension spray pipe.
Preferably, the driving circuit further comprises an air filter, the air filter is connected to the air pump, and the air filter is used for filtering the air output by the air pump.
Compared with the prior art, the invention has the beneficial effects that:
the invention discloses a cell suspension atomization device, which realizes the atomization effect of cell suspension by controlling a driving part to drive a supply part through an electric control part, improves the activity rate of cells and the uniform distribution on a spraying surface in the suspension atomization process, shortens the re-epithelialization period and reduces the treatment cost. In addition, the device controls the mechanical driving part or the pneumatic driving part through the electric control part to drive the fog drops formed by the supply part to be attached to the target spraying area on the skin in a gentle mode, and no stimulation is caused.
The foregoing description is only an overview of the technical solutions of the present invention, and in order to make the technical solutions of the present invention more clearly understood and to implement them in accordance with the contents of the description, the following detailed description is given with reference to the preferred embodiments of the present invention and the accompanying drawings. The detailed description of the present invention is given in detail by the following examples and the accompanying drawings.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the invention without limiting the invention. In the drawings:
FIG. 1 is an overall structural view of a cell suspension atomizing apparatus according to the present invention;
FIG. 2 is a schematic view of one embodiment of a cell supply assembly of the cell suspension nebulizing device of the present invention;
FIG. 3 is a schematic view of another embodiment of the cell supply assembly of the cell suspension nebulizing device of the present invention;
FIG. 4 is a logic diagram of the pneumatic control method of the pneumatic driving circuit of the cell suspension atomization device according to the present invention;
reference numerals: 100. the cell supply device comprises a cell supply assembly, 110, a mechanical drive part, 111, a linear drive, 112, a motor, 113, a control interface, 120, a mechanical supply part, 121, a push rod, 122, an injection piece, 123, a connector, 124, a clamping block, 10, suspension, 210, an air pressure drive circuit, 211, an air pump, 212, an air filter, 213, a switch valve, 214, a pressure regulating valve, 215, an air storage tank, 2151, a pressure release valve, 2152, a first pressure sensor, 216, an electric control valve, 217, a second pressure sensor, 218, a two-way valve, 219, a filter core, 220, an air pressure supply part, 221, an atomizing spray gun, 222, an orifice, 223 and a sealing tank.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and the detailed description, and it should be noted that any combination of the embodiments or technical features described below can be used to form a new embodiment without conflict.
The invention provides a cell suspension atomizing device, which comprises an atomizing device body, as shown in fig. 1-3, wherein the atomizing device body comprises a cell supply assembly 100, a feedback assembly and a control assembly, and the control assembly is connected with the cell supply assembly 100 and the feedback assembly; the control assembly comprises an electrical control part and a data acquisition part, wherein the electrical control part is electrically connected with the data acquisition part; the data acquisition part is used for receiving the data acquired by the feedback assembly and sending the acquired data to the electrical control part; the cell supply assembly 100 comprises a driving part and a supply part, wherein the driving part is connected with the supply part, the driving part is connected with an electrical control part, the supply part is connected with a data acquisition part, and the electrical control part adjusts the driving part according to data acquired by the data acquisition part, so that the driving part drives the supply part to atomize and spray suspension in the driving part to a target spraying area on the skin. In one embodiment, the feedback assembly comprises a plurality of sensors, the sensors are used for monitoring the cell supply assembly and feeding collected data back to the data collection part, the data collection part processes the received data and sends the processed data to the electric control part, the electric control part sends an instruction to the driving part through processing and analyzing the data, and the driving part drives the supply part to atomize and spray suspension in the supply part. The atomization device has a cell suspension with stable flow output through the matching of the control component and the feedback component; the atomization device body controls the driving part through the electric control part to enable gas with certain pressure to form high-speed airflow in the supply part, so that high relative speed is formed between the gas and the cell suspension liquid, a liquid column or a liquid film is damaged, the flowing property, apparent viscosity and surface tension of the liquid are changed, and meanwhile, the liquid part of the continuous phase is changed into dispersivity to achieve the atomization effect. In the embodiment, single-cell atomization spraying is used, so that the formation of closed cell clusters is avoided, and the formation of bad symptoms such as blisters in repair is prevented.
In a specific embodiment, as shown in fig. 3, the driving portion includes a mechanical driving portion 110, the mechanical driving portion 110 includes a motor 112, a linear driver 111 and a push rod 121, the motor 112 is electrically connected to the electrical control portion, and the linear driver 111 is connected to the motor 112 and the push rod 121; the feedback assembly comprises a position sensor (not shown in the figure), the position sensor collects the position of the supply part and feeds the collected data back to the data collection part, and the electric control part adjusts the motor 112 to drive the linear driver 111 to move along a direction according to the data fed back by the data collection part, so that the push rod 121 drives the supply part to atomize and spray the suspension in the supply part to a target spraying area on the skin. The supply part comprises a mechanical supply part 120, the mechanical supply part 120 comprises an injection piece 122, a clamping block 124 and a joint 123, the injection piece 122 is connected with a push rod 121, the push rod 121 is used for sucking or discharging the suspension into or out of the injection piece 122, the injection piece 122 is fixedly arranged on the clamping block 124, and the joint 123 is fixedly arranged at one end of the injection piece 122 and is used for connecting a suspension spray pipe. In this embodiment, the motor 112 is preferably one of a micro stepper motor, a dc motor or an ac motor, the motor 112 is electrically connected to the electrical control unit through the control interface 113, and the electrical control unit precisely controls the movement of the linear actuator 111 to control the push rod 121 to drive. Preferably, the linear driver 111 may be driven in a plurality of driving manners, which is not limited in this embodiment, for example: screw drive, magnetic drive, electric drive. The injection member 122 is preferably a syringe, which may be a standard 5ml or 10ml syringe secured by a mechanical clamping block 124, and the connector 123 of the syringe may be a straight-line connector or a luer connector, the connector 123 of the syringe being connected to the suspension nozzle.
In an alternative embodiment, as shown in fig. 2, the driving portion includes a pneumatic driving circuit 210, the pneumatic driving circuit 210 includes an air pump 211, an electric control valve 216, an air storage tank 215, and a two-way valve 218, the air pump 211 delivers air into the air storage tank 215, the feedback assembly includes a first pressure sensor 2152, the first pressure sensor 2152 is used for collecting pressure of air in the air storage tank 215 and feeding back collected data to the data collecting portion, the electric control valve 216 and the two-way valve 218 are electrically connected to the electric control portion, and the electric control portion adjusts the electric control valve 216 according to feedback data of the data collecting portion, so that the pneumatic driving supply portion 220 atomizes and sprays suspension therein to a target area to be sprayed on the skin. The supply part comprises a pneumatic supply part 220, the pneumatic supply part 220 comprises a sealed tank 223 and an atomizing spray gun 221, and the electric control part regulates an electric control valve 216 to convey driving gas in the gas storage tank 215 into the sealed tank 223, so that suspension in the sealed tank 223 is sprayed to a target spraying area on the skin through the atomizing spray gun 221 under the action of air pressure. The pneumatic driving circuit 210 further includes a second pressure sensor 217, and the second pressure sensor 217 is configured to collect pneumatic data output from the gas tank 215 and feed the data back to the data collecting unit. The pneumatic driving circuit 210 further includes a filter element 219, the filter element 219 is connected to the seal tank 223, and the filter element 219 is used for filtering the airflow entering the seal tank 223.
In this embodiment, the suspension is atomized by using air pressure as a driving force, in this embodiment, an oil-free and water-free air pump 211 outputting air pressure of 0.5MPa to 1MPa is selected according to the requirement of cell atomization, the compressed air is filtered by an air filter 212, the compressed air is controlled to enter the air storage tank 215 by a manual switch valve 213 or an electric switch valve 213, a pressure regulating valve 214 is used for controlling the air pressure of the compressed air in the air storage tank 215, the air pressure in the air storage tank 215 can be controlled to be 0.03MPa to 0.5MPa according to the requirement of cell suspension atomization with different viscosity coefficients, and the first pressure sensor 2152 is used for monitoring the air pressure state in the air storage tank 215. The gas holder 215 is also provided with a pressure release valve 2151, and when the atomizer body works, the pressure release valve 2151 is closed, and when the atomizer body does not work, the pressure release valve 2151 is opened.
In this embodiment, the electric control valve precisely controls the output of the air flow, and the air pressure output is fed back by the second pressure sensor 217, the second pressure sensor 217 feeds back the acquired data to the data acquisition unit, the data acquisition unit processes the received data and sends the processed data to the electric control unit, and the electric control unit automatically adjusts the electric control valve to obtain the control parameters after analyzing the received data. The two-way valve 218 is used for controlling the opening or closing of the pneumatic driving circuit 210; to ensure the sterility of the cell suspension during atomization, a filter element with a filter hole diameter of 0.22um is preferably adopted to filter the airflow before entering the sealed tank.
In one embodiment, the air pressure supply 220 further comprises an orifice 222, the orifice 222 is installed between the seal pot 223 and the atomizing spray gun 221, and the orifice 222 is used for enabling the atomizing spray gun 221 to output a constant flow of the suspension. In this embodiment, the orifice 222 is selected to have a suitable size to stably output a constant flow of cell suspension, and the orifice has a pore size of 100um-500um, preferably 100um-250 um.
In one embodiment, the atomization lance 221 comprises a suspension nozzle and a filter (not shown) mounted at one end of the suspension nozzle (not shown) for filtering the suspension before entering the suspension nozzle, the filter having a filter orifice with a diameter of 0.2 to 0.5 times the inner diameter of the suspension nozzle. In this embodiment, the cell suspension passes through the filter before entering the suspension nozzle, the filter can prevent the occurrence of the problem of blockage of the atomization nozzle during the use of the atomization spray gun, and the aperture of the filter hole of the filter is 0.2-0.5 times, preferably 0.2-0.3 times of the inner diameter of the suspension nozzle.
It should be noted that the atomization device body of the invention can be used for atomization of growth factors, hydrogel and collagen suspension besides atomization of cell suspension.
In one embodiment, as shown in fig. 4, the pneumatic control method of the pneumatic driving circuit 210 includes the following steps:
first, the air pump 211, the on-off valve 213 and the adjusting valve 214 are opened, and the air pressure in the air storage tank 215 is set by the adjusting valve 214;
the second step is that: controlling the electric control valve 216 by using an electric control part in the control assembly to adjust the output air pressure, and waiting for an air injection instruction of the atomizing spray gun 221 when the air pressure reaches a preset set pressure value;
the third step: when an air injection instruction of the atomizing spray gun 221 is received, the two-way valve 218 is opened, at the moment, the airflow outlet of the atomizing spray gun 221 can spray gas with stable airflow, and an air injection ending instruction is waited;
the fourth step: when receiving the air injection end command, closing the two-way valve 218 and waiting for the work end command;
the fifth step: when the work ending instruction is not received, waiting for the next air injection instruction of the atomizing spray gun 221; when receiving the end-of-work instruction, the on-off valve 213, the pressure regulating valve 214, the electric control valve 216, and the air pump 211 are closed, the pressure release valve 2151 is opened, the pressure in the air tank 215 is reduced to zero, and finally the pressure release valve 2151 is closed.
The invention provides a cell suspension atomization device, which enables a supply part to form high-speed airflow due to pressure through controlling mechanical drive or air pressure drive by an electric control part, so that very high relative speed is formed between gas and cell suspension, a liquid column or a liquid film is damaged, the flowing property, apparent viscosity and surface tension of liquid are changed, and meanwhile, the liquid part of a continuous phase is changed into dispersibility to achieve the atomization effect; the device improves the activity rate of cells in the suspension atomization process and the uniform distribution on the spraying surface, shortens the re-epithelialization period and reduces the treatment cost. In addition, the device controls the mechanical driving part or the pneumatic driving part through the electric control part to drive the fog drops formed by the supply part to be attached to the target spraying area on the skin in a gentle mode, and no stimulation is caused. The device is applied to the treatment of deep skin wounds or large-area skin burns, the pain time of a patient is shortened, the dosage of expensive skin regenerative cells or other biological medicines is reduced, and the treatment cost is reduced.
The foregoing is merely a preferred embodiment of the invention and is not intended to limit the invention in any manner; those skilled in the art can readily practice the invention as shown and described in the drawings and detailed description herein; however, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention without departing from the scope of the invention as defined by the appended claims; meanwhile, any changes, modifications, and evolutions of the equivalent changes of the above embodiments according to the actual techniques of the present invention are still within the protection scope of the technical solution of the present invention.
Claims (10)
1. The cell suspension atomization device is characterized by comprising an atomization device body, wherein the atomization device body comprises a cell supply assembly, a feedback assembly and a control assembly, and the control assembly is connected with the cell supply assembly and the feedback assembly; wherein the content of the first and second substances,
the control assembly comprises an electrical control part and a data acquisition part, and the electrical control part is electrically connected with the data acquisition part; the data acquisition part is used for receiving the data acquired by the feedback assembly, and the data acquisition part sends the acquired data to the electrical control part;
the cell supply assembly comprises a driving part and a supply part, the driving part is connected with the electric control part, the supply part is connected with the data acquisition part, and the electric control part adjusts the driving part according to the data acquired by the data acquisition part, so that the driving part drives the supply part to atomize and spray the suspension inside the supply part to a target spraying area on the skin.
2. The cell suspension atomizing device according to claim 1, wherein the driving part includes a mechanical driving part, the mechanical driving part includes a motor, a linear actuator and a push rod, the motor is electrically connected to the electrical control part, and the linear actuator is connected to the motor and the push rod; the feedback assembly comprises a position sensor, the position sensor collects the position of the supply part and feeds collected data back to the data collection part, the electric control part adjusts the motor to drive the linear driver to move along one direction according to the data fed back by the data collection part, so that the push rod drives the supply part to atomize and spray suspension inside the supply part to a target spraying area on the skin.
3. The cell suspension atomizing device according to claim 2, wherein the supply part comprises a mechanical supply part, the mechanical supply part comprises an injection member, a clamping block and a joint, the injection member is connected with the push rod, the push rod is used for sucking or discharging the suspension into or out of the interior of the injection member, the injection member is fixedly mounted on the clamping block, and the joint is fixedly mounted at one end of the injection member and is used for connecting a suspension spray pipe.
4. The cell suspension atomizing device according to claim 1, wherein the driving portion includes a pneumatic driving circuit, the pneumatic driving circuit includes an air pump, an electrical control valve, an air storage tank, and a two-way valve, the air pump delivers air into the air storage tank, the feedback assembly includes a first pressure sensor, the first pressure sensor is used for collecting pressure of air in the air storage tank and feeding collected data back to the data collecting portion, the electrical control valve and the two-way valve are electrically connected to the electrical control portion, and the electrical control portion adjusts the electrical control valve according to the feedback data of the data collecting portion, so that the air pressure drives the supplying portion to atomize and spray the suspension inside the supplying portion to the target spraying area on the skin.
5. The cell suspension atomization device of claim 4, wherein the supply part comprises a gas pressure supply part, the gas pressure supply part comprises a sealed tank and an atomization spray gun, and the electric control part regulates the electric control valve to convey the driving gas in the gas storage tank into the sealed tank, so that the suspension in the sealed tank is sprayed to a target spraying area on the skin through the atomization spray gun under the action of gas pressure.
6. The cell suspension atomization device of claim 4, wherein the pneumatic drive circuit further comprises a second pressure sensor for collecting pneumatic data output from the gas storage tank and feeding the data back to the data collection unit.
7. The cell suspension atomization device of claim 5, wherein the pneumatic drive circuit further comprises a filter element, the filter element is connected with the seal pot, and the filter element is used for filtering the airflow entering the seal pot.
8. The cell suspension atomization device of claim 5, wherein the air pressure supply further comprises an orifice, the orifice is mounted between the sealed tank and the atomization lance, and the orifice is used for enabling the atomization lance to output a constant flow of the suspension.
9. The cell suspension atomizing device of claim 4, wherein the atomizing spray gun comprises a suspension spray pipe and a filter, the filter is arranged at one end of the suspension spray pipe and is used for filtering the suspension before entering the suspension spray pipe, and the aperture of the filter hole of the filter is 0.2-0.5 times of the inner diameter of the suspension spray pipe.
10. The cell suspension atomizing device according to claim 4, wherein the driving circuit further comprises an air filter, the air filter is connected to the air pump, and the air filter is used for filtering the air output by the air pump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910934672.2A CN110639099B (en) | 2019-09-29 | Cell suspension atomizing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910934672.2A CN110639099B (en) | 2019-09-29 | Cell suspension atomizing device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110639099A true CN110639099A (en) | 2020-01-03 |
| CN110639099B CN110639099B (en) | 2024-05-17 |
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