CN1106300A - Artificial tendon, its prodn. method and application - Google Patents
Artificial tendon, its prodn. method and application Download PDFInfo
- Publication number
- CN1106300A CN1106300A CN 94118418 CN94118418A CN1106300A CN 1106300 A CN1106300 A CN 1106300A CN 94118418 CN94118418 CN 94118418 CN 94118418 A CN94118418 A CN 94118418A CN 1106300 A CN1106300 A CN 1106300A
- Authority
- CN
- China
- Prior art keywords
- tendon
- artificial
- artificial tendon
- stndon sheath
- sheath
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The artificial tendon 109HH that may be transplanted into human body is mainly composed of artificial tendon body and/or tendon sheath. Said artificial tendon body is made of processed human hair and said tendon sheath is biological substrate membrane processed. The artificial tendon has the advantages of the ability for early function exercise, prevention of tendon bond, and pull stress increasing as time. It finally becomes the tendon tissue of organism itself in 3 months after transplantation.
Description
The invention belongs to and a kind ofly can be transplanted to the intravital artificial succedaneum of people, particularly can be transplanted to the intravital artificial tendon of people and manufacture method and use in a kind of.
In the period of 1935-59, Teneff Fanda Bunell studies " allogeneic tendon ", and finding after testing has the downright bad stage, only plays the support effect and rejection is arranged.From 1977, Jenkens studied " carbon fiber tendon ", once reached China's extensive use abroad, carbon fiber and nonprotein do not have rejection in human body, but still are carbon fiber in human body after further test is found 18 months, and broken, only form to form and organize adventitia, not tendonization.To China in 1980 wear the gram army with silica gel for tendon, still, silica gel tendon adhesion easily slides, can not combine together in the convergence part, do not absorbed in the body, easy to break, and just become foreign body once infecting.China yellowish glaucoma ring in 1988 with the human hair for tendon, its tension is difficult for decay, but can not be absorbed by human body, can not change into body self tendon by tendon, just become foreign body once infecting, to stick together with tissue and can only be used for big power tendon such as heel string, can not be used for hands, foot bends and stretches tendon.
The objective of the invention is to solve problems of the prior art, make the tension of artificial tendon approach normal tendon, after it implants human body, strengthen gradually, finally reach the tension of normal tendon.
Another object of the present invention is to make that artificial tendon can be absorbed by body, tendonization, becomes the human body tendon at last.
Another purpose of the present invention is to make artificial tendon have the performance of very fast recovery normal function, no longer than fracture sew up from body tendon healing time.
A further object of the present invention is to make artificial tendon not have rejection in vivo, and with the surrounding tissue adhesion, sliding capability is not good, and finally combines together in its stitching convergence part.
109HH artificial tendon of the present invention mainly is made up of artificial tendon body and/or stndon sheath, wherein the Main Ingredients and Appearance of artificial tendon body is through the human hair after the short tendon processing of series, and be woven into different length, different thicknesses and the series of products that is used for the different human body position, stndon sheath wherein is a kind of flaky bio-based counterdie of dry product that becomes after treatment.
The manufacture method of 109HH artificial tendon body of the present invention is:
With allochthonous Crinis Carbonisatus through clean, after the defat, under 2-105 ℃ temperature, concentration is to handle 1.5-250 hour in the bases medicine that contains potassium and sodium of 3-35%, putting into oxidant after the cleaning again handles, it is fixing to put into glutaraldehyde after cleaning again, clean at last and autoclaving, be packaged in the plastic foil pocket, can preserve at normal temperatures at ordinary times.
The manufacture method of the stndon sheath of artificial tendon of the present invention is:
Get fresh allogeneic biomembrane in the 0.01-0.5% weakly alkaline solution; the rinsing of repeatedly vibrating; after under aseptic condition, drawing materials then; in for 7.2-7.6 concentration being the protection liquid of 0.02M, pH value adds antibiotics; divide to be installed on to preserve in 2 ℃-10 ℃ in several weeks and use; or can protect 10-30 days in-30 ℃ to-10 ℃, or make dry product and preserved 3 months.Above-mentioned bio-based counterdie is human Placenta Hominis.
The using method of 109HH artificial tendon of the present invention is:
Before operation, artificial tendon body is taken out from plastic bag, wrap up the back again with gauze and use autoclaving sterilization in the lump, on operating-table, place physiological saline solution with operating equipment.As perform the operation need outer during by artificial stndon sheath, should be with its outer being wrapped in around the artificial tendon body, and suitably be sutured on the artificial tendon body, do not slide substantially, but can make artificial tendon body exposed at the two ends of its convergence part weave on the tendon stump so that sew up when being connected.When artificial stndon sheath uses, should be with its plastic bag adventitia with 3.5% iodine disinfection, take off behind the iodine and to cut off the back with sterile scissors and take out and be put on the aseptic operation table, and place aseptic physiological saline solution, through about 30 minutes, just reach user mode, again it is wrapped in around the artificial tendon body and sutured on artificial tendon body.
Result behind the 109HH artificial tendon implant into body of the present invention is:
(1) became body self with the spline structure tendinous tissue in three months behind the implant into body;
(2) tension of 3-6 month new tendon can reach 94% of normal body tendon behind the implant into body;
(3) local all do not have rejection with whole body;
(4) with preventing adhesion behind biological thin film (artificial stndon sheath) the parcel artificial tendon body, do not influence tendonization again.
The curative effect of 109HH artificial tendon of the present invention is: clinical practice 35 examples, total effects is 100%, wherein excellently accounts for 94.3%, very accounts for 5.7%.
The advantage of 109HH artificial tendon of the present invention is:
(1) with after the artificial tendon repairing reconstruction, can carry out function exercise in early days, (three weeks of upper limb, six weeks of lower limb), this is consistent with the functional rehabilitation time after the human body tendon rupture stitching;
(2) artificial tendon body has prevented the tendon adhesion with artificial stndon sheath applied in any combination, does not influence tendonization again;
(3) tension is unattenuated behind the implant into body, and extends in time and strengthen, and reaches the tension of human body tendon at last;
(4) the back tendinous tissue that can become body self in three months of operation.
109HH artificial tendon of the present invention except that clinical practice, carried out (1) zoopery again; (2) ultrastructural studies; (3) electron microscopic observation of tendon process; (4) the Crinis Carbonisatus lymphocyte transformation cellular immunization index determining after short tendon processing; (5), all obtained the good result of expection with of the comparative test of other artificial tendon in in-vivo tissue evolution.
109HH artificial tendon series of products typing of the present invention is:
(1) V, H, the F upper limb hands tendon of counting on one's fingers; (2) the finger tendon stretched of V, H, E upper limb hands; (3) I, F, F lower limb are bent the toe tendon; (4) I, F, F lower limb are stretched the toe tendon; (5) K, L knee joint ligamena collateralia; (6) K, E, L cruciate ligaments of knee; (7) TH heel string.
In order to further specify the curative effect of 109HH artificial tendon of the present invention, especially exemplified by going out following case:
Case one:
Zhu * *, man, 40 years old, because of traffic accident causes the inside and outside collateral ligament break in a left side, left front due to cruciate ligament, the closed folding of the cross-section property of left patella, left common peroneal nerve paralysis was admitted to hospital in three days, the back patella folding row steel wire annular of being admitted to hospital is fixing, with preceding main ligament of this tendon generation, with the 109HH artificial tendon to the capable Reconstruction of medial ligament, the not prudent exercise of three weeks of postoperative, prudent behind the one and a half months, knee joint function is satisfied, and common peroneal nerve is restore funcitons, and outside tension test is normal in the left knee joint, examine again after three months, patient's gait freely, the joint is stable, the swelling of no joint, stair activity freely, patient can drive motorcycle and automobile.
Case two:
Liu * *, the man, 22 years old, because of traffic accident causes right lateral collateral ligament fracture, posterior cruciate ligament fracture, and local skin avulsion, carry out the debridement closure of wound in local hospital, sense instability of knee and institute seeking medical advice after month to me, and lateral collateral ligament is carried out Reconstruction with the 109HH artificial tendon, simultaneously with the 109HH artificial tendon to the capable replacement of posterior cruciate ligament art, and attached with the bio-based counterdie outside artificial tendon.Go the function of joint exercise gradually in six weeks of postoperative, patient can be prudent, gait freely, the joint is stable, lateral movement and drawer test feminine gender.
Case three:
Lee * *, the man, 20 years old, because of left hand abduction pollicis muscles tendon hinder that the back lacks as, sought medical advice in 2 years, the back surgical findings of being admitted to hospital lacks as 8cm, and rebuilds the defective region tendon with the 109HH artificial tendon, thumb in the wrong can be independently stretched in postoperative function satisfaction, it is undamped to follow up a case by regular visits to tension.
Claims (4)
1, a kind of artificial tendon, it mainly is made up of artificial tendon body and/or stndon sheath, the Main Ingredients and Appearance that it is characterized in that described artificial tendon body is through the human hair after the short tendon processing of series, and be woven into different length, different thicknesses and be used for the series of products at different human body position, described artificial stndon sheath is a kind of flaky bio-based counterdie of dry product that becomes after treatment.
2, artificial tendon as claimed in claim 1 is characterized in that described bio-based counterdie is human Placenta Hominis.
3, a kind of manufacture method of artificial tendon comprises the manufacture method of artificial tendon body and artificial stndon sheath:
(1) making step of described artificial tendon body is: with allochthonous Crinis Carbonisatus through clean, after the defat, under 2-105 ℃ temperature, concentration is to handle 1.5-250 hour in the bases medicine that contains potassium and sodium of 3-35%, putting into oxidant after the cleaning again handles, it is fixing to put into glutaraldehyde after cleaning again, clean at last and autoclaving, be packaged in the plastic foil pocket, can preserve at normal temperatures at ordinary times;
(2) making step of described artificial stndon sheath is: get fresh allogeneic biomembrane in the 0.01-0.5% weakly alkaline solution; the rinsing of repeatedly vibrating; after under aseptic condition, drawing materials then; in for 7.2-7.6 concentration being the protection liquid of 0.02M, pH value adds antibiotics; divide to be installed on to preserve in 2 ℃-10 ℃ in several weeks and use; or can protect 10-30 days in-30 ℃ to-10 ℃, or make dry product and preserved 3 months.
4, a kind of using method of artificial tendon the steps include:
(1) before operation, artificial tendon body is taken out from plastic bag, wrap up the back again with gauze and use autoclaving sterilization in the lump, and place the physiological saline solution on the operating-table with operating equipment;
When (2) needing with artificial stndon sheath as operation, earlier the plastics of artificial stndon sheath are cut off with sterile scissors with 3.5% iodine disinfection, after taking off iodine for adventitia, taking-up is put in the physiological saline solution on the operating-table, through about 30 minutes, just can use, be wrapped in it around artificial tendon body and sutured on artificial tendon body, but can make artificial tendon body exposed at the two ends of its convergence part, be knitted on the tendon stump so that sew up when being connected.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94118418 CN1106300A (en) | 1994-10-22 | 1994-10-22 | Artificial tendon, its prodn. method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94118418 CN1106300A (en) | 1994-10-22 | 1994-10-22 | Artificial tendon, its prodn. method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1106300A true CN1106300A (en) | 1995-08-09 |
Family
ID=5038823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 94118418 Pending CN1106300A (en) | 1994-10-22 | 1994-10-22 | Artificial tendon, its prodn. method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1106300A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998036710A1 (en) * | 1997-02-21 | 1998-08-27 | Nan Fang Hospital | An artificial tendon, a method for preparing the same and application thereof |
| CN1315539C (en) * | 2002-12-20 | 2007-05-16 | 上海第二医科大学附属第九人民医院 | Tendon tissue engineered seed cell-hypodermal fibroblast |
-
1994
- 1994-10-22 CN CN 94118418 patent/CN1106300A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998036710A1 (en) * | 1997-02-21 | 1998-08-27 | Nan Fang Hospital | An artificial tendon, a method for preparing the same and application thereof |
| CN1315539C (en) * | 2002-12-20 | 2007-05-16 | 上海第二医科大学附属第九人民医院 | Tendon tissue engineered seed cell-hypodermal fibroblast |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Narakas | The use of fibrin glue in repair of peripheral nerves | |
| Barillo et al. | Management of burns to the hand | |
| Messina | The double armed suture: tendon repair with immediate mobilization of the fingers | |
| CN1106300A (en) | Artificial tendon, its prodn. method and application | |
| Tamai et al. | Major limb, hand, and digital replantation | |
| Li et al. | Split-thickness nail bed flap graft in the management of distal partial defect of the nail bed combined with soft tissue | |
| Sekiguchi et al. | Youngest replantation with microsurgical anastomoses | |
| RU2297804C1 (en) | Method for finger reconstruction | |
| Al-Dubaiban et al. | Flexor tendon–to–volar plate repair: an experimental study and 3 case reports | |
| Chicarilli | Pediatric microsurgery: revascularization and replantation | |
| STRAUCH et al. | Replantation of Digits. | |
| Xie et al. | Methods and Strategies of Microsurgery Combined with Ilizarov Technique in the Treatment of Amputation of Limbs in Renji Hospital: A Report of 51 Cases | |
| O'BRIEN et al. | Saving the amputated digit and hand | |
| Weeks | Hand injuries | |
| Adams | Staged extensor tendon reconstruction in the finger | |
| Kim et al. | Hyperbaric oxygen therapy and prostaglandin usage for shred injury of the fingers: a case report | |
| SCHMITZ et al. | Two-Stage Flexor Tendon Reconstruction in the Hand. | |
| Xu et al. | Microsurgical treatment for bilateral thumb defect: five case reports | |
| Hernández Jiménez et al. | Fascia lata as an alternative in dental treatments | |
| Macrì et al. | Current Principles in the Management of a Mangled Hand | |
| Malik et al. | Case Report: Hand Replantation at The Mid Palm Level | |
| Weili et al. | One Case of Abandoned Little Finger to Reconstruct Thumb and Repair Soft Tissue Defect | |
| Friedrich | Wounds and Soft-Tissue Injuries | |
| Tayah | Evaluation of functional recovery after upper limb replantation: Evaluation of functional recovery after upper limb replantation | |
| Patel | Ward Procedures, 5/e |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |