CN110585220A - Application of glucoside compound in preparation of medicine for preventing and treating pancreatic lesion - Google Patents
Application of glucoside compound in preparation of medicine for preventing and treating pancreatic lesion Download PDFInfo
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- CN110585220A CN110585220A CN201810602429.6A CN201810602429A CN110585220A CN 110585220 A CN110585220 A CN 110585220A CN 201810602429 A CN201810602429 A CN 201810602429A CN 110585220 A CN110585220 A CN 110585220A
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- abnormal increase
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- UAEJRRZPRZCUBE-UHFFFAOYSA-N trimethoxyalumane Chemical compound [Al+3].[O-]C.[O-]C.[O-]C UAEJRRZPRZCUBE-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to an application of a glucoside compound, pharmaceutically acceptable salt or hydrate thereof, or any combination thereof in preparing a medicament for preventing and treating pancreatic diseases. The compound can be used for preparing medicaments for preventing and treating pancreatic diseases, and particularly can prevent and treat pancreatic diseases caused by the increase of the volume of pancreatic islets/cytosis.
Description
Technical Field
The invention relates to application of a glucoside compound in preparing a medicament for preventing and treating pancreatic diseases.
Background
The pancreas has two parts, one is pancreas, which is an exocrine gland, and produces pancreatic juice; the second is the islets, which are like islands in the sea, and are organs formed by a pile of cells in the pancreas, and the islets are endocrine glands and produce insulin. Therefore, the pancreas is the only gland in the human body, namely the exocrine gland and the endocrine gland, and is a special organ. The pancreas has two functions of endocrine and exocrine, the endocrine of the pancreas mainly refers to the secretion of insulin, the insulin is an important hormone which enables cells to utilize glucose in blood, and after a person eats a full meal, the blood sugar in the blood rises, and the insulin is released into the blood, so that the glucose enters the cells to be utilized by the cells, and the blood sugar is reduced. Exocrine secretion of the pancreas refers to pancreatic juice, which contains various substances such as trypsin and amylase and acts on intestinal tract to decompose proteins. The pancreas is one of the very important organs of the human body, and if the pancreas is damaged, the generation and release of internal and external secretions can be influenced, so that the health of the human body is influenced. For example, abnormal increase of insulin will lead to hyperinsulinemia, which is the common basis of coronary heart disease, hypertension, hyperlipidemia, type II diabetes, obesity, stroke, etc.
Disclosure of Invention
The invention aims to provide an application of a glucoside compound in preparation of a medicine for preventing and treating pancreatic diseases, in particular to the application of the glucoside compound in prevention and treatment of pancreatic diseases related to diabetes.
Specifically, the invention firstly provides an application of a glycoside compound shown as a structural formula (I), a pharmaceutically acceptable derivative or chemical variant thereof, or any combination thereof in preparing a medicament for preventing and treating pancreatic diseases:
wherein: a is independently selected from-OR5Group orA group; b is independently selected from-OR5Group orA group; and a and b are not simultaneously selected from the same group;
and: r1～R7Each independently selected from H, C1～C6Alkyl radical, C2～C6Alkenyl or C2～C6Alkynyl.
The invention also provides application of the compound shown as the structural formula (I), a pharmaceutically acceptable derivative or chemical variant thereof, or any combination thereof in preparing a medicament for preventing and treating pancreatic islet volume enlargement or/and islet cell enlargement.
The invention also provides application of the compound shown as the structural formula (I), a pharmaceutically acceptable derivative or chemical variant thereof, or any combination thereof in preparing a medicament for preventing and treating the islet volume increase and/or the islet cytosis of a type 1 or type 2 diabetes patient.
The invention also provides a compound shown as the structural formula (I), a pharmaceutically acceptable derivative or chemical variant thereof, or any combination thereof in the preparation of a medicament for preventing and treating abnormal increase of islet volume or/and abnormal increase of islet cells related to hyperinsulinemia.
The invention also provides a compound shown as the structural formula (I), a pharmaceutically acceptable derivative or chemical variant thereof, or any combination thereof, which is used for preparing a medicine for preventing and treating abnormal increase of islet volume or/and abnormal increase of islet cells related to leptin abnormality or/and leptin receptor abnormality; further, it is used for treating abnormal increase of islet volume or/and abnormal increase of islet cells related to spontaneous mutation of leptin receptor.
Diabetes is a chronic and non-infectious disease which seriously affects human health, the incidence rate of the diabetes is on the rise in recent years, and the diabetes becomes an important public health problem in China. The etiology of type II diabetes is complex, the pathogenesis of type II diabetes is not completely clear, insulin resistance and islet B cell dysfunction are the main pathophysiological characteristics of type II diabetes, and the B cell dysfunction is the driving factor for the generation and development of type II diabetes and the main reason for poor metabolic control of type II diabetes.
The occurrence of the disease can refer to the condition before or after the diabetes develops, which can be generated when a treatment medicament is not taken, or the condition generated when a patient takes the treatment medicament, wherein the taking of the medicament refers to the condition that the diabetes patient takes the medicament for treating the diabetes symptoms, and the condition comprises the step of taking the compound shown in the structural formula (I) for reducing the blood sugar.
In the above-mentioned application, the first and second substrates,
r in the formula (I)1～R6Can be selected as H.
R in the formula (I)7And may alternatively be H.
R in the formula (I)1～R7Can be selected as H.
The compound can also be a compound shown as a formula (II) or an enantiomer or diastereoisomer, a racemic mixture or an isotopologue thereof:
the compound can also be a compound shown as a formula (III) or an enantiomer or diastereoisomer, a racemic mixture or an isotopologue thereof:
in the practice of the above application, an effective dose of the drug should be selected.
The dosage of the compound can be selected conventionally under the dosage of 1-500 mg/kg when the compound is applied to a human body; the dosage of the mouse is converted conventionally according to the dosage of the mouse, and the dosage can be selected to be 8.85-17.7 mg/kg.
The application of the invention can obviously inhibit pancreatic diseases and prevent and treat the symptoms of islet volume increase and/or islet cell increase of type 1 or type 2 diabetes patients.
The pharmaceutical composition containing the compound of the invention or the stereoisomer, solvate, hydrate, pharmaceutically acceptable salt or cocrystal thereof can contain pharmaceutically acceptable auxiliary materials.
As used herein, "pharmaceutically acceptable" is meant to include any material that does not interfere with the effectiveness of the biological activity of the active ingredient and is not toxic to the host to which it is administered.
The pharmaceutically acceptable auxiliary materials are general names of all the additional materials except the main medicine in the medicine, and the auxiliary materials have the following properties: (1) no toxic effect on human body and few side effects; (2) the chemical property is stable and is not easily influenced by temperature, pH, storage time and the like; (3) has no incompatibility with the main drug, and does not influence the curative effect and quality inspection of the main drug; (4) does not interact with the packaging material. The auxiliary materials in the invention include, but are not limited to, a filler (diluent), a lubricant (glidant or anti-adhesion agent), a dispersing agent, a wetting agent, an adhesive, a regulator, a solubilizer, an antioxidant, a bacteriostatic agent, an emulsifier, a disintegrating agent and the like. The binder comprises syrup, acacia, gelatin, sorbitol, tragacanth, cellulose and its derivatives (such as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or hydroxypropyl methylcellulose), gelatin slurry, syrup, starch slurry or polyvinylpyrrolidone; the filler comprises lactose, sugar powder, dextrin, starch and its derivatives, cellulose and its derivatives, inorganic calcium salt (such as calcium sulfate, calcium phosphate, calcium hydrogen phosphate, precipitated calcium carbonate, etc.), sorbitol or glycine, etc.; the lubricant comprises superfine silica gel powder, magnesium stearate, talcum powder, aluminum hydroxide, boric acid, hydrogenated vegetable oil, polyethylene glycol and the like; the disintegrating agent comprises starch and its derivatives (such as sodium carboxymethyl starch, sodium starch glycolate, pregelatinized starch, modified starch, hydroxypropyl starch, corn starch, etc.), polyvinylpyrrolidone or microcrystalline cellulose, etc.; the wetting agent comprises sodium lauryl sulfate, water or alcohol, etc.; the antioxidant comprises sodium sulfite, sodium bisulfite, sodium pyrosulfite, dibutylbenzoic acid, etc.; the bacteriostatic agent comprises 0.5% of phenol, 0.3% of cresol, 0.5% of chlorobutanol and the like; the regulator comprises hydrochloric acid, citric acid, potassium (sodium) hydroxide, sodium citrate, and buffer (including sodium dihydrogen phosphate and disodium hydrogen phosphate); the emulsifier comprises polysorbate-80, sorbitan fatty acid, pluronic F-68, lecithin, soybean lecithin, etc.; the solubilizer comprises Tween-80, bile, glycerol, etc.
The term "pharmaceutically acceptable salt" refers to a salt of a compound of the present invention with an acid or base that is suitable for use as a pharmaceutical. The acid base is a generalized Lewis acid base. Suitable acids for forming the salts include, but are not limited to: inorganic acids such as hydrochloric acid, hydrobromic acid, hydrofluoric acid, sulfuric acid, nitric acid, phosphoric acid, etc., organic acids such as formic acid, acetic acid, propionic acid, oxalic acid, malonic acid, succinic acid, fumaric acid, maleic acid, lactic acid, malic acid, tartaric acid, citric acid, picric acid, methanesulfonic acid, phenylmethanesulfonic acid, benzenesulfonic acid, etc.; and acidic amino acids such as aspartic acid and glutamic acid.
The mode of administration of the compounds or pharmaceutical compositions of the present invention is not particularly limited, and representative modes of administration include (but are not limited to): oral, inhalation, parenteral (intravenous, intramuscular or subcutaneous), injection and topical administration.
Solid dosage forms for oral administration include capsules, tablets, pills, powders and granules. In these solid dosage forms, the active compound is mixed with at least one conventional inert excipient (or carrier), such as sodium citrate or dicalcium phosphate, or with the following ingredients: (a) fillers or extenders, for example, starch, lactose, sucrose, glucose, mannitol and silicic acid; (b) binders, for example, hydroxymethylcellulose, alginates, gelatin, polyvinylpyrrolidone, sucrose and acacia; (c) humectants, for example, glycerol; (d) disintegrating agents, for example, agar-agar, calcium carbonate, potato or tapioca starch, alginic acid, certain complex silicates, and sodium carbonate; (e) slow solvents, such as paraffin; (f) absorption accelerators, e.g., quaternary ammonium compounds; (g) wetting agents, such as cetyl alcohol and glycerol monostearate; (h) adsorbents, for example, kaolin; and (i) lubricants, for example, talc, calcium stearate, magnesium stearate, solid polyethylene glycols, sodium lauryl sulfate, or mixtures thereof. In capsules, tablets and pills, the dosage forms may also comprise buffering agents.
Solid dosage forms such as tablets, dragees, capsules, pills, and granules can be prepared using coatings and shells such as enteric coatings and other materials well known in the art. They may contain opacifying agents and the release of the active compound or compounds in such compositions may be delayed in release in a certain part of the digestive tract. Examples of embedding components which can be used are polymeric substances and wax-like substances. If desired, the active compound may also be in microencapsulated form with one or more of the above-mentioned excipients.
Liquid dosage forms for oral administration include pharmaceutically acceptable emulsions, solutions, suspensions, syrups or tinctures. In addition to the active compounds, the liquid dosage forms may contain inert diluents commonly employed in the art such as, for example, water or other solvents, solubilizing agents and emulsifiers, e.g., ethyl alcohol, isopropyl alcohol, ethyl carbonate, ethyl acetate, propylene glycol, 1, 3-butylene glycol, dimethylformamide, and oils, especially cottonseed, groundnut, corn germ, olive, castor and sesame oils, or mixtures of such materials, and the like.
In addition to these inert diluents, the compositions can also contain adjuvants such as wetting agents, emulsifying and suspending agents, sweetening, flavoring, and perfuming agents.
Suspensions, in addition to the active compounds, may contain suspending agents as, for example, ethoxylated isostearyl alcohols, polyoxyethylene sorbitol and sorbitan esters, microcrystalline cellulose, aluminum methoxide and agar, or mixtures of these substances, and the like.
Compositions for parenteral injection may comprise physiologically acceptable sterile aqueous or anhydrous solutions, dispersions, suspensions or emulsions, and sterile powders for reconstitution into sterile injectable solutions or dispersions. Suitable aqueous and nonaqueous carriers, diluents, solvents or vehicles include water, ethanol, polyols and suitable mixtures thereof.
Dosage forms for topical administration of the compounds of the present invention include ointments, powders, patches, sprays, and inhalants. The active ingredient is mixed under sterile conditions with a physiologically acceptable carrier and any preservatives, buffers, or propellants which may be required if necessary.
The compounds of the invention can likewise be used in injectable preparations. Wherein the injection is selected from liquid injection (water injection), sterile powder for injection (powder injection) or tablet for injection (refers to impression tablet or machine pressing tablet prepared by aseptic operation method of medicine, and is dissolved with water for injection for subcutaneous or intramuscular injection when in use).
Wherein the powder for injection contains at least an excipient in addition to the above compound. The excipients, which are components intentionally added to a drug in the present invention, should not have pharmacological properties in the amounts used, however, the excipients may aid in the processing, dissolution or dissolution of the drug, delivery by a targeted route of administration, or stability.
The prevention and treatment of the invention refers to prevention or/and treatment.
Drawings
FIG. 1 is a graph of pathological staining of pancreas representative of the groups of mice in example 1;
FIG. 2 is the result of the statistics of islet pathology scores of the mice in each group in example 1.
Detailed Description
The compound (marked as H2) shown as the structural formula (II) can be obtained by a preparation method of a compound 15 reported in technical literature separation and identification of chemical components of coptis water extract (Lexue modification, etc., Shenyang pharmaceutical science university, 29 rd 3 rd, 193 rd 198 p. of 2012), and other compounds shown as the structural formula (I) can be prepared by the method,
the examples are according to the "drug registration management method" (the national food and drug administration order No. 28, 2007, 10 and 01); the drug non-clinical research quality control code (national food and drug administration directive No.2, 09/01/2003) was defined.
Examples in addition to the compound of the structural formula (I), a 0.5 g/tablet metformin tablet (Shanghai Shibaoji pharmaceutical Co., Ltd., China, America) was used as a control drug, and distilled water was used for the preparation of the drugs in the examples.
Other reagents or test instruments selected in the examples include 50% glucose injection (20 mL/vial, product of Korea, pharmaceutical Co., Ltd.), Roche Excellent gold-sharp blood glucose test paper (product of Roche diagnostics GmbH), and Roche Excellent blood glucose meter (product of Roche diagnostics GmbH).
Examples the basic conditions of the subjects before the experiment were carried out were:
(1) selecting db/db and db/m mice with SPF grades to breed according to GB14925-2010, wherein the breeding environment is temperature: 20-26 ℃ (daily temperature difference <4 ℃); illumination: artificial illumination, 12 hours of light and shade alternation; and (3) ventilation frequency: the air exchange times in the non-working time are more than or equal to 15 times/hour and more than or equal to 10 times/hour.
Feeding density: less than or equal to 5 pieces/cage; cage spatial displacement frequency: <1 time/week.
The maintenance feed (provided by Shanghai Slek laboratory animals, Inc.) is fed to the large and small mice during the feeding period, the maintenance feed is freely taken by the mice, and the indexes of conventional nutrient components in the nutrient components of the feed are as follows: crude protein, crude fat, crude fiber, crude ash, moisture, calcium, and phosphorus; amino acid index: threonine, cystine + methionine, valine, isoleucine, leucine, tyrosine + phenylalanine, histidine, lysine, arginine, tryptophan, see GB 14924.3-2010; chemical pollutant indexes in the confirmation of the feed pollutant content are as follows: arsenic, lead, cadmium, mercury, hexachloro cyclohexane, dichlorodiphenyl trichloroethane, aflatoxin B1, total number of colonies, coliform group, number of mould and yeast, and pathogenic bacteria (salmonella), as referred to GB 14924.2-2001.
The reverse osmosis water was fed as drinking water and was freely taken by the mice.
(2) Example the experiment was carried out by pre-conditioning for 4 days, and thereafter selecting mice with normal state and body weight up to standard, including 72 male db/db mice and 12 male db/m mice aged about 9 weeks, wherein the average body weight of the db/m mice was 26.7-34.0 g, the average body weight of the db/db mice was 40.7-55.6 g, and the individual body weight values were within ± 20% of the average.
db/db mouse model: the blood sugar of more than 7.8mmol/L is brought into a model group of type 2 diabetes (the minimum value of the blood sugar of the db/db model group is 7.8mmol/L, which is obviously higher than the average value of the db/m control group is 5.6)
Example 1
The selected mice were randomly grouped according to fasting blood glucose measured before the first administration (wherein, the blank control group, the negative control group, the positive control group, the H2 low dose group, the H2 medium dose group and the H2 high dose group are db/db mice), and 12 mice were grouped as shown in Table 1:
TABLE 1 mouse grouping
The grouped mice were dosed according to the following dosing pattern:
the administration route is as follows: performing oral gavage;
the administration frequency is as follows: once daily for 12 weeks;
wherein db/m group, blank control group and negative control group: distilled water is given;
positive control group: administering a positive drug, metformin;
other administration groups: administering different doses of test agent H2;
the amounts administered (or distilled water) are shown in table 2:
TABLE 2 dosage for different groups of mice
Pancreas was dissected out from mice after completion of administration (12 weeks of continuous administration), and the pathological results of pancreas tissues showed that pancreatic islets were proliferated and increased in different degrees in the remaining groups of db/db type 2 diabetes mice in this test period as compared with those in the normal control group (db/m group).
Pathological staining analysis was performed on pancreatic tissues of mice of different groups obtained by dissection, and the pathological grading principle criteria described in the reference literature (Fermented Milk has Anti-metabolic Effects: Anti-metabolic Effects of Fermented Milk contact products of Diabetes Mellitus), which is classified into 0-4 grades, according to staining images (fig. 1 shows the pathological staining results of animal pancreas, and fig. 1 shows the db/m group, the negative control group, the positive control group, the H2 low dose group, the H2 medium dose group, and the H2 high dose group from left to right, and from top to bottom in this order), and the number and severity of the islets with hyperplasia, the larger the pathological grading score, which is shown in table 3:
TABLE 3 pathological grading of the dose in different groups of mice
"N" represents normal tissue morphology; "E" represents a change in the morphological structure of the tissue; "-" indicates the absence of the lesion
Statistical analysis of the scoring results (as shown in fig. 2 of the specification, wherein P <0.05, P <0.01, and P <0.001), the islets of Langerhans of the remaining groups of mice were increased in volume or number to a different extent than those of db/m groups of mice of the normal control group, indicating that abnormal proliferation of islet cells may occur during the onset of diabetes.
The positive drug metformin is particularly obvious in increase of islet volume or quantity, and compared with a negative control group, the pathological score is obviously increased; the negative control group is also very different from the db/m group (P < 0.001); the mice in the low dose group using the H2 compound had relatively reduced islet volume increase or number increase, but no statistical difference; compared with a negative control group, the mice with the medium-dose and high-dose groups of the H2 compound have extremely obviously reduced islet volume increase or quantity increase degree and have statistical difference (P <0.001), and the results show that the test drug H2 has the effect of reducing pancreatic islet lesions and has certain dose correlation, while the first-line diabetes treatment drug metformin has no effect. This conclusion also indicates that whether the drug has hypoglycemic effect, or the intensity of hypoglycemic effect, is not directly related to the inhibition or alleviation of pancreatic disorders in diabetic patients.
Based on the dose condition of mice and the basic knowledge of experimental control, the preferable dose is 8.85-17.7 mg/kg body weight per day when the composition is used in human bodies.
Claims (10)
1. The application of a compound shown as a structural formula (I), a pharmaceutically acceptable salt or hydrate thereof, or any combination of the compound and the pharmaceutically acceptable salt or hydrate thereof in preparing a medicament for preventing or/and treating pancreatic lesion:
wherein: a is independently selected from-OR5Group orA group; b is independently selected from-OR5Group orA group; and a and b are not simultaneously selected from the same group;
and: r1～R7Each independently selected from H, C1～C6Alkyl radical, C2～C6Alkenyl or C2～C6Alkynyl.
2. Use according to claim 1, characterized in that: the pancreatic lesion refers to abnormal increase of islet volume or/and abnormal increase of islet cells.
3. Use according to claim 1 or 2, characterized in that: the pancreatic lesion refers to abnormal increase of islet volume or/and abnormal increase of islet cells of a type 1 or type 2 diabetic patient.
4. Use according to claim 1 or 2, characterized in that: the pancreatic lesion refers to abnormal increase of islet volume or/and abnormal increase of islet cells related to hyperinsulinemia.
5. Use according to claim 1 or 2, characterized in that: the pancreatic lesion refers to abnormal increase of islet volume or/and abnormal increase of islet cells related to leptin abnormality or/and leptin receptor abnormality; further, the pancreatic lesion refers to abnormal increase of islet volume or/and abnormal increase of islet cells associated with spontaneous mutation of leptin receptor.
6. The application of the compound shown as the structural formula (I), the pharmaceutically acceptable salt or hydrate thereof, or any combination of the compound and the pharmaceutically acceptable salt or hydrate thereof in preparing the medicines for preventing and treating the abnormal increase of the volume of the pancreatic islets and/or the abnormal increase of the pancreatic islet cells.
7. Use according to any one of claims 1 to 6, wherein R1～R6Are all H.
8. Use according to any one of claims 1 to 6, wherein R7Is H.
9. Use according to any one of claims 1 to 6, wherein R1～R7Are all H.
10. The use according to any one of claims 1 to 6, wherein the compound is a compound represented by formula (II) or formula (III):
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105012334A (en) * | 2014-04-25 | 2015-11-04 | 西安世纪盛康药业有限公司 | Medicinal composition for treating renal diseases and pharmaceutical use of medicinal composition |
| CN107519191A (en) * | 2016-06-22 | 2017-12-29 | 成都中创蜀洋生物科技有限公司 | Glucoside compound is preparing the purposes in treating diabetes medicament |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105012334A (en) * | 2014-04-25 | 2015-11-04 | 西安世纪盛康药业有限公司 | Medicinal composition for treating renal diseases and pharmaceutical use of medicinal composition |
| CN107519191A (en) * | 2016-06-22 | 2017-12-29 | 成都中创蜀洋生物科技有限公司 | Glucoside compound is preparing the purposes in treating diabetes medicament |
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