CN110585037A - Method for effectively promoting penetration of beauty polypeptide - Google Patents
Method for effectively promoting penetration of beauty polypeptide Download PDFInfo
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- CN110585037A CN110585037A CN201910766616.2A CN201910766616A CN110585037A CN 110585037 A CN110585037 A CN 110585037A CN 201910766616 A CN201910766616 A CN 201910766616A CN 110585037 A CN110585037 A CN 110585037A
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- Prior art keywords
- polypeptide
- beauty
- carbitol
- cosmetic
- beauty polypeptide
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 48
- 229920001184 polypeptide Polymers 0.000 title claims abstract description 44
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 44
- 230000003796 beauty Effects 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 14
- 230000001737 promoting effect Effects 0.000 title claims abstract description 11
- 230000035515 penetration Effects 0.000 title claims description 7
- 239000002537 cosmetic Substances 0.000 claims abstract description 32
- MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical compound C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 claims abstract description 9
- 229940075559 piperine Drugs 0.000 claims abstract description 9
- WVWHRXVVAYXKDE-UHFFFAOYSA-N piperine Natural products O=C(C=CC=Cc1ccc2OCOc2c1)C3CCCCN3 WVWHRXVVAYXKDE-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000019100 piperine Nutrition 0.000 claims abstract description 9
- BHUIUXNAPJIDOG-UHFFFAOYSA-N Piperonol Chemical compound OCC1=CC=C2OCOC2=C1 BHUIUXNAPJIDOG-UHFFFAOYSA-N 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 208000020154 Acnes Diseases 0.000 claims description 2
- 206010014970 Ephelides Diseases 0.000 claims description 2
- 206010020751 Hypersensitivity Diseases 0.000 claims description 2
- 208000003351 Melanosis Diseases 0.000 claims description 2
- 208000026935 allergic disease Diseases 0.000 claims description 2
- 230000007815 allergy Effects 0.000 claims description 2
- 230000002087 whitening effect Effects 0.000 claims description 2
- 230000037303 wrinkles Effects 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 11
- 210000004207 dermis Anatomy 0.000 abstract description 4
- 230000000052 comparative effect Effects 0.000 description 13
- 210000003491 skin Anatomy 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 238000005070 sampling Methods 0.000 description 6
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 5
- 239000013543 active substance Substances 0.000 description 5
- 238000009792 diffusion process Methods 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- QUGMSTJBNZWXQS-BHVCSQLQSA-N Kadsurin Natural products O=C(O[C@H]1[C@@H](C)[C@H](C)Cc2c(c(OC)c(OC)c(OC)c2)-c2c(OC)c3OCOc3cc12)C QUGMSTJBNZWXQS-BHVCSQLQSA-N 0.000 description 3
- QUGMSTJBNZWXQS-SQHYZVFZSA-N Kadsurin, (-)- Chemical compound COC1=C2C=3C(OC)=C(OC)C(OC)=CC=3C[C@@H](C)[C@@H](C)[C@@H](OC(C)=O)C2=CC2=C1OCO2 QUGMSTJBNZWXQS-SQHYZVFZSA-N 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000003961 penetration enhancing agent Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000007515 enzymatic degradation Effects 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001502 supplementing effect Effects 0.000 description 2
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 1
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
- 108010087806 Carnosine Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 108010016626 Dipeptides Proteins 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 1
- 102000000591 Tight Junction Proteins Human genes 0.000 description 1
- 108010002321 Tight Junction Proteins Proteins 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 1
- 229940044199 carnosine Drugs 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000007180 physiological regulation Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a method for effectively promoting percutaneous absorption of beauty polypeptide, which is characterized in that carbitol (B) and piperine (C) are added into a cosmetic containing (A) beauty polypeptide, and the adding weight ratio range of the carbitol (B) to the piperine (C) is 50:1-10: 1. The invention can effectively improve the transdermal absorption of the beauty polypeptide, increase the content of the beauty polypeptide in the dermis layer, improve the effect of the beauty polypeptide in the application of cosmetics and have a predictable effect on the beauty polypeptide in the field of the effect of cosmetics.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a method for effectively promoting percutaneous absorption of beauty polypeptide, and medical application thereof, particularly application of skin beauty.
Background
The beauty polypeptide is usually a condensate of 2-10 amino acids, the molecular weight is mainly distributed as 300-1500, compared with other active substances, the beauty polypeptide has certain transdermal absorbability due to small molecular weight, but the beauty polypeptide is formed by connecting amino groups through peptide bonds, the molecular weight difference of different amino acid numbers is large, the beauty polypeptide is simultaneously affected by different amino acid types, most of the peptide sections have strong hydrophilicity and charges, the common passive diffusion transdermal absorption rate cannot achieve the ideal transdermal effect, and the effective part of the skin cannot achieve enough content to exert the ideal effect.
In order to overcome the skin barrier effect, promote the cosmetic polypeptide components to enter the dermis layer of the skin and play various physiological regulation roles on skin cells, the transdermal absorption of the cosmetic polypeptide components is usually promoted by means of some new technologies, and the transdermal absorption rate of the cosmetic polypeptide components is increased by means of a physical permeation-promoting mode of an instrument and by adding some permeation-promoting agents. However, the existing physical permeation-assisting method has the defects of high price, complicated use and the like, and common chemical permeation-accelerating agents such as azone, surfactants, organic acids and the like are easy to cause skin allergy and can cause damage to the skin after long-time or large-dose use.
Therefore, the method for promoting the transdermal absorption of the polypeptide, which can be rapidly applied to the cosmetics, is developed, and has important research significance for the application of the polypeptide in the cosmetics.
Carbitol is a good transdermal enhancer, the structure of the skin is not changed, the permeability of the active substance can be improved and the transdermal absorption of the active substance can be increased by changing the distribution coefficient of the active substance between the skin and the carrier, and the Carbitol is safe and has no stimulation within the range of 1-10% of the theoretical addition amount; piperoxin can increase mobile phase of skin lipid bilayer, open intercellular tight junction protein, and is natural penetration enhancer, which can effectively increase diffusion coefficient of active substance in skin, and theoretical addition amount is 0.01-0.1%. Carbitol and piperonyl alcohol are mainly used as chemical penetration enhancers for cosmetic products or are mainly used for compounding with azone products at present. The compounding use of carbitol and piperine in a beauty polypeptide product for promoting transdermal absorption has not been reported.
Disclosure of Invention
In view of the deficiencies of the prior art, the present invention provides a method for effectively inhibiting enzymatic degradation of cosmetic polypeptides, and the medical use of said compounds, particularly in skin cosmetics, including in the field of repair,
in order to achieve the purpose, the invention provides the following technical scheme:
a method for effectively promoting penetration of beautifying polypeptide includes adding carbitol (B) and piperine (C) to the cosmetics containing beautifying polypeptide (A).
Preferably, the cosmetic polypeptide (A) comprises one or more of dipeptide, tripeptide, tetrapeptide, pentapeptide, hexapeptide, octapeptide and nonapeptide.
Preferably, in cosmetic applications, the product comprising the cosmetic polypeptide has a carbitol (B) and piperine (C) added in a weight ratio ranging from 50:1 to 10: 1.
The application of the method for effectively inhibiting enzymatic degradation of beauty polypeptide is disclosed, and the cosmetic is various cosmetic preparations with the functions of whitening, removing freckles, resisting wrinkles, moisturizing, removing acnes, resisting allergy, relieving and the like.
In summary, the following steps:
compared with the prior art, the method for promoting transdermal absorption of the beauty polypeptide is simple, the permeation promoting effect is obviously superior to azone, the compatibility is good, the safety and the efficiency are high, the transdermal absorption of the beauty polypeptide can be effectively improved, the content of the beauty polypeptide in a dermis layer is increased, the effect of the beauty polypeptide in the application of cosmetics is improved, and the effect of the beauty polypeptide in the effect field of the cosmetics can be expected.
The carbitol and the piperonyl alcohol are compounded in a certain proportion to be used as an efficient penetration enhancer, so that the preparation method has the advantages of high efficiency, safety, simple method and wide application range, has good capability of promoting transdermal absorption for most beauty polypeptides, particularly beauty polypeptides with the molecular weight higher than 500, can effectively improve the content of the beauty polypeptides in a dermis layer and improve the application effect of the beauty polypeptides in cosmetics, is lower in price compared with azone, can properly reduce the cost of the cosmetics, and has obvious significance for the application of the beauty polypeptides.
Drawings
FIG. 1 is a graph showing a comparison of the cumulative permeation of the cosmetic polypeptides in examples 1-4 and comparative examples 1-6.
Detailed Description
The examples of a method of the present invention for effectively enhancing transdermal absorption of a cosmetic polypeptide are further illustrated:
in vitro transdermal penetration test (tested by RJY-6B type drug transdermal diffusion tester)
Taking pig ear back skin, removing hair and fat, cutting 3 × 3cm skin disc, and storing in-20 deg.C refrigerator for use.
When in use, the preserved skin round piece is taken out, naturally thawed, soaked in normal saline for 0.5h, wiped by absorbent cotton, and fixed in a vertical permeation test diffusion cell.
Adding a proper amount of normal saline with a sodium chloride solution of which the mass concentration is 0.9% into a receiving pool as receiving liquid, adding implementation case samples (about 1-2g, weighing and recording) into a supply pool, sealing the supply pool by using a sealing film after adding, starting magnetic stirring at the speed of 300r/min, slowly extracting all the receiving liquid by using an injector for 2h, 4h, 6h, 8h and 12h respectively, measuring the concentration of the cosmetic polypeptide by using HPLC (high performance liquid chromatography), extracting a proper amount of heat-preservation normal saline (about 6-7g and capable of filling the receiving pool) by using a needle tube after each liquid extraction, and supplementing the normal saline back to the receiving pool, and taking out the receiving pool after 12h and then not supplementing the normal saline. The instrument set temperature was 32. + -. 5 ℃.
Calculation of the permeation concentration of cosmetic polypeptide μ g/cm 2:
(CnVn +. Sigma CkVk). times.1000/2.8 cm2 (wherein: Cn-the peptide concentration measured at the nth sampling point, mg/mL; Ck-the peptide concentration measured corresponding to all sampling points before the nth sampling point, mg/mL; Vn-the volume of the receiving solution, mL; Vk-the sampling volume corresponding to all sampling points before the nth sampling point, mL)
Example 1
A: preparing a cosmetic polypeptide solution: 0.1% of carnosine, 25% of glycerol, 1% of 1, 2 hexanediol, 0.1% of ethylhexyl glycerol and 70-80% of water, and the initial peptide content is detected after configuration; b: 1% of carbitol; c, 0.01 percent of piperine, and uniformly stirring and dissolving A, B and C to obtain a sample of the supply pool.
Example 2
Example 2 differs from example 1 in that: and the content of the kadsurin in the C is 0.03 percent.
Example 3
Example 3 differs from example 1 in that: and the content of the kadsurin in the C is 0.05 percent.
Example 4
Example 4 differs from example 1 in that: and the content of the kadsurin in the C is 0.1 percent.
Comparative example 1:
comparative example 1 differs from example 1 in that: c, carbitol 0.01 percent.
Comparative example 2:
comparative example 2 differs from example 1 in that: c, carbitol 0.03%.
Comparative example 3:
comparative example 3 differs from example 1 in that: c, carbitol 0.05 percent.
Comparative example 4:
comparative example 4 differs from example 1 in that: c, 0.1 percent of carbitol.
Comparative example 5:
comparative example 5 differs from example 1 in that: no B was added.
Comparative example 6:
comparative example 6 differs from example 1 in that B and C are not added, and azone of equal mass B and C is added.
The test result is shown in figure 1, under the condition of equal amount of penetration enhancer, the transdermal absorption effect of the carbitol and the piperine mixed according to a certain proportion is better than that of the carbitol used alone, and the carbitol and the piperine have synergistic penetration enhancing effect on the beauty polypeptide.
The above description is provided for further details of the present invention with reference to specific modified embodiments, and it should not be considered that the present invention is limited to these specific embodiments, and it should be understood that those skilled in the art may make several simple deductions or substitutions without departing from the spirit of the present invention, and all such alternatives are deemed to fall within the scope of the present invention.
Claims (3)
1. A method for effectively promoting penetration of beauty polypeptide is characterized in that: carbitol (B) and piperine (C) are added into cosmetics containing the cosmetic polypeptide (A).
2. The method of claim 1, wherein the carbitol (B) and the piperonyl alcohol (C) are added in a weight ratio of 50:1 to 10:1 in a cosmetic product containing the polypeptide.
3. The use of claim 3, wherein the cosmetic is various cosmetic preparations for whitening, removing freckles, resisting wrinkles, preserving moisture, removing acnes, resisting allergy, relieving and the like.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910766616.2A CN110585037A (en) | 2019-08-20 | 2019-08-20 | Method for effectively promoting penetration of beauty polypeptide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910766616.2A CN110585037A (en) | 2019-08-20 | 2019-08-20 | Method for effectively promoting penetration of beauty polypeptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110585037A true CN110585037A (en) | 2019-12-20 |
Family
ID=68855008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910766616.2A Pending CN110585037A (en) | 2019-08-20 | 2019-08-20 | Method for effectively promoting penetration of beauty polypeptide |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110585037A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606668A (en) * | 2015-02-06 | 2015-05-13 | 深圳唯美度生物科技有限公司 | Breast enlargement gel containing complex polypeptides and process thereof |
| CN109419665A (en) * | 2017-08-25 | 2019-03-05 | 汉义生物科技（北京）有限公司 | A kind of active matter rapid osmotic system containing Cannador or cannabidiol |
-
2019
- 2019-08-20 CN CN201910766616.2A patent/CN110585037A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606668A (en) * | 2015-02-06 | 2015-05-13 | 深圳唯美度生物科技有限公司 | Breast enlargement gel containing complex polypeptides and process thereof |
| CN109419665A (en) * | 2017-08-25 | 2019-03-05 | 汉义生物科技（北京）有限公司 | A kind of active matter rapid osmotic system containing Cannador or cannabidiol |
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