CN110578664A - Electrospinning microfluidic injection pump system - Google Patents
Electrospinning microfluidic injection pump system Download PDFInfo
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- CN110578664A CN110578664A CN201910777621.3A CN201910777621A CN110578664A CN 110578664 A CN110578664 A CN 110578664A CN 201910777621 A CN201910777621 A CN 201910777621A CN 110578664 A CN110578664 A CN 110578664A
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- 239000007924 injection Substances 0.000 title claims abstract description 69
- 238000002347 injection Methods 0.000 title claims abstract description 69
- 238000001523 electrospinning Methods 0.000 title claims description 8
- 239000012530 fluid Substances 0.000 claims abstract description 21
- 238000004401 flow injection analysis Methods 0.000 claims abstract description 17
- 238000010041 electrostatic spinning Methods 0.000 claims abstract description 14
- 239000007788 liquid Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 9
- 239000004065 semiconductor Substances 0.000 claims description 7
- 239000003990 capacitor Substances 0.000 claims description 6
- 238000004891 communication Methods 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 230000003287 optical effect Effects 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 4
- 101100339482 Colletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) HOG1 gene Proteins 0.000 claims description 3
- 230000005540 biological transmission Effects 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 2
- 238000012360 testing method Methods 0.000 claims description 2
- 238000012546 transfer Methods 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims 2
- 239000000243 solution Substances 0.000 abstract description 11
- 230000009471 action Effects 0.000 abstract description 4
- 230000005684 electric field Effects 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 5
- 101100270233 Dictyostelium discoideum arrH gene Proteins 0.000 description 4
- 101100323734 Dictyostelium discoideum arrL gene Proteins 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000002121 nanofiber Substances 0.000 description 4
- 239000002184 metal Substances 0.000 description 3
- 238000007792 addition Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
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- 238000005070 sampling Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B17/00—Pumps characterised by combination with, or adaptation to, specific driving engines or motors
- F04B17/03—Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B49/00—Control, e.g. of pump delivery, or pump pressure of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for, or of interest apart from, groups F04B1/00 - F04B47/00
- F04B49/06—Control using electricity
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B53/00—Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Reciprocating Pumps (AREA)
Abstract
The invention discloses a micro-flow injection pump system for electrostatic spinning, which comprises injection pumps, drive plates, a control plate and an upper computer, wherein the upper computer is communicated with the control plate in an interconnected manner, the control plate is respectively connected with a plurality of micro-flow injection pumps through the drive plates, the core of the injection pump is a stepping motor, the stepping motor rotates to drive a top sliding table to move left and right, and an injector is fixed on the sliding table. The drive plate supports high subdivision drive operation of the stepping motor. The control panel receives the host computer instruction through the 485 serial ports to control the action of the injection pump. The upper computer is a high-definition display screen, and is used for displaying the solution injection amount and the progress in real time besides setting system operation parameters. The micro-fluid pump system supports an upper computer to control a plurality of injection pumps simultaneously. The invention has high running precision and convenient operation, and the injection speed range can reach 0.1 mL/h-50 mL/h.
Description
Technical Field
The invention relates to a design of a micro-flow injection pump system for electrostatic spinning, and relates to the technical field of nano-material preparation and medical device manufacturing.
background
in recent years, nano materials are widely applied in social production and life. The electrostatic spinning technology is the most common method for preparing polymer nano-fibers in the field of materials at present, polymer solution is pushed out from a micro-flow pump with a capillary at a certain speed, the capillary part is placed in a strong electric field, and the polymer solution can form a Taylor cone at the top end of the capillary under the action of the strong electric field; gradually increasing the electric field strength until the polymer solution overcomes the surface tension to form a jet stream; the jet stream irregularly moves in a strong electric field and is split into a plurality of strands of filament fibers, and finally the nanofibers in the form of non-woven fabrics are formed at the negative electrode of the electric field. The micro-flow injection pump is used as an important feeding device in the electrostatic spinning process, and the running precision and stability of the micro-flow injection pump directly influence the quality of the produced nano-fibers. Most of the micro-fluid pump systems in the existing market have complex structures and single management and control modes, and cannot automatically and accurately reflect the running state of the micro-fluid injection pump in real time.
Disclosure of Invention
the invention mainly aims to solve the problem that automatic low-speed accurate feeding cannot be realized in the field of electrostatic spinning, and designs a micro-flow injection pump system for electrostatic spinning, which has a simple structure and can accurately reflect the operation state of the system in real time under the condition of ensuring the operation accuracy.
A micro-flow injection pump system for electrostatic spinning comprises an injection pump, a drive plate, a control plate and an upper computer, wherein the upper computer is communicated with the control plate in an interconnected manner, the control plate is respectively connected with a plurality of micro-flow injection pumps through a plurality of drive plates,
The miniflow injection pump includes lead screw, step motor, guide rail, slip table, injection pump body, and lead screw, step motor, guide rail all set up the inside at the injection pump body, wherein: the guide rail is arranged at the bottom, the stepping motor is arranged at one end of the guide rail, and the screw rod is fixed on the stepping motor and rotates along with the operation of the stepping motor; the injector is fixed on the injection pump body through the bracket; the upper part of the sliding table is fixedly connected with the tail part of the movable plug of the injector, the lower part of the sliding table is provided with a threaded hole which is sleeved on the screw rod in a matching way, and the bottom of the sliding table is arranged on the guide rail;
the stepping motor works to drive the screw rod to rotate, the screw rod enables the sliding table to be pushed or pulled back on the guide rail based on the threaded hole of the sliding table, and the pushing and pulling process of the sliding table provides power for the movable plug of the injector to realize injection or liquid taking.
The two-phase hybrid lead screw stepping motor is selected as the stepping motor, and the requirements of low stepping angle, large torque and high precision are met.
Preferably, the inside of syringe pump body sets up left spacing opto-coupler and right spacing opto-coupler respectively at the both ends of lead screw, advances to opto-coupler department when the slip table and stops immediately.
Preferably, the injection pump body is externally provided with a forward button and a backward button which are respectively used for controlling the forward and backward rotation of the stepping motor, so that the manual control is facilitated.
Specifically, the driving board is an LV8729 motor driving chip of the semiconductor corporation, and MD1-MD3 pins of the LV8729 chip are all pulled to be high level to realize a 128-subdivision driving mode.
Preferably, the LV8729 chip supports automatic half-current locking, the OSC2 pin thereof is grounded through a capacitor C5, and the capacitance value of C5 determines the time interval for entering the half-current state; the VREF pin of the LV8729 chip is connected to the resistor R10, and to the DOWN pin through the resistor R11, where R10 is R11.
Preferably, the OSC1 pin of the LV8729 chip is grounded through a capacitor C4, and C5 is used to set the current chopping frequency.
Specifically, the control board is stm32f407 of the ideological semiconductor company, and outputs a pulse signal with a fixed frequency based on a timer function of stm32 to control the stepping motor so as to control the liquid taking or injection speed of the injector.
The pulse control signal output from the stm32 timer pin is isolated and amplified and added to the STP end of LV8729, and the driving current is respectively introduced to the two-phase windings of the stepping motor, so that the motor driving is completed, and the liquid taking or injection speed control of the injector is realized.
Preferably, the speed V of the withdrawal or injectionsThe relationship with the timer reload value ARR is:
In the formula, a is the screw pitch of a motor screw rod; r is the radius of the inner wall of the injector; m is a fine value set by the driving of the stepping motor; PSC is a frequency division coefficient of a timer;
Controlling the liquid taking or injection speed V of the micro-fluid injection pump system by controlling the ARR values。
Preferably, the speed V of taking or injectingsthe control process of (2) further comprises a calibration step, wherein the calibration step is to test the injection V before the system runs every timexWeighing the distilled water with mass m by a precision balancexG; after the calibration step is added, the liquid is taken or the injection speed V is measuredsthe relationship with the timer reload value ARR is:
Wherein Δ ═ Vx/mx。
Preferably, an MCGS touch screen is used as an upper computer of the system, a user control instruction is calculated and sent, the operation condition of the injection pump system is monitored in real time, the upper computer corresponds to one or more injection pumps, the upper computer sends a control instruction to a control panel through a 485 bus, a Modbus communication protocol is defined, 7 bytes are transmitted in one-time communication according to a format of address codes, function codes, data length, data bits and CRC16 check bits, the address codes respectively correspond to the same main control chip address, the function codes correspond to different states of the motor including positive, reverse, stop and reset, the data length is 2 bytes, and the data bits are high and low bytes of operation parameters of the control motor; the CRC16 check ensures that the data transfer is accurate.
The invention has the advantages of
This miniflow syringe pump main part uses accurate, low step angle step motor, and each mechanical parts is accurate laminates, realizes high subdivision drive to the motor with high accuracy step motor drive chip LV 8729. The precision of the micro-flow injection pump is improved, the optional injection speed range is wide under the condition of ensuring the running precision, and the requirement of electrostatic spinning is completely met; meanwhile, the high-definition touch screen is used as an upper computer of the system, operation is convenient, the running state and the injection execution progress of the system can be fed back in real time, the feeding state is reflected more visually, automation is realized, and the working efficiency is improved. And one host computer is supported to control a plurality of micro-fluid pump systems, and two operation modes, namely manual operation and automatic operation, are respectively supported, so that the controllability is strong, and the cost is low.
Drawings
FIG. 1 is a schematic diagram of the overall structure of the present invention
FIG. 2 is a schematic view of the main structure of a micro-fluid injection pump according to the present invention
FIG. 3 is a schematic diagram of the application of the present invention in the field of electrospinning
FIG. 4 is a schematic circuit diagram of a motor driving board of a micro-fluid pump according to the present invention
FIG. 5 is a schematic diagram of a control circuit for a control board of a micro-fluid pump system according to the present invention
FIG. 6 is a flow chart illustrating operation of a micro fluid pump system according to the present invention
Detailed Description
The invention is further illustrated by the following examples, without limiting the scope of the invention:
As shown in fig. 1: the design main structure of the micro-flow injection pump system comprises a micro-flow injection pump, a stepping motor drive (an LV8729 drive plate, an LV8729 motor drive chip of the Sanyo semiconductor company), a lower computer master control module (an STM32 control plate, STM32f407 of the Italy semiconductor company) and an upper computer (MCGS touch screen). The micro-flow injection pump main body is designed as follows:
As shown in fig. 2: the micro-fluid pump system adopts a two-phase mixed screw rod stepping motor 2 as a core of a system main body, and the motor 2 has the requirements of low stepping angle, large torque and high precision; as a better embodiment, a Wheatstone 42 stepping motor is selected as the motor 2 of the injection pump system, the fixed step angle of the stepping motor 2 is 1.8 degrees, and the motor rotates 1.8 degrees when the power-on state is changed once under the condition of not adding the fine driving. 200 step pulse signals are needed for one rotation of the rotor. Because the motor speed of control is lower, will divide the drive to the motor, after adding the subdivision drive technique, the step angle of motor can corresponding reduce, and under M subdivision drive, the step angle theta of motor is 1.8/M, and the rotor rotates a week and needs 200M step pulse signal. The motor has the advantages of high positioning precision, low rotational inertia and the like. In order to further improve the precision of the injection pump, the screw 1 integrated with the stepping motor is selected from a ball screw, and as a better embodiment, the ball screw with the lead of 2mm is selected.
The motor screw rod 1 is connected with a sliding table 4 outside the injection pump body 5, a linear guide rail 3 playing a supporting role is arranged below the sliding table 4, the screw rod 1 rotates to drive the sliding table 4 to move forwards and backwards, and a clamping device is arranged above the sliding table 4 and used for fixing a movable plug 6-1 of the injector 6; fixing an empty cylinder of the injector 6 at the top end of the micro-flow pump, clamping a movable plug 6-1 of the injector 6 into a clamping device of the sliding table 4, moving the sliding table 4 to push and pull the movable plug 6-1 of the injector, and finishing liquid taking and injection of the injector 6;
And two limit switches (7-1; 7-2) are respectively arranged at two ends of the stroke of the sliding table 4, and when the sliding table 4 moves to the optical coupler, the limiting switches stop immediately to protect the injector 6 and the sliding table 4. As a better embodiment, the micro-fluidic pump system adopts an ITR9606 groove type correlation photoelectric sensor as a limit switch, and a metal baffle is arranged on the sliding table 4 at a position corresponding to a U-shaped groove of the photoelectric switch. When the metal baffle plate does not reach the limit position, the signal output of the limit switch is low level; when the metal baffle reaches the limit position, the receiving end cannot receive the optical signal, and the signal output of the limit switch is high level. The signal output terminals C of all limit switches are connected to the common IO pin of stm 32.
The top end of the micro-fluid pump body is provided with a forward button 8-1 and a backward button 8-2 for manual control; the button has one terminal connected to ground and one terminal connected to the normal IO pin of stm 32.
As shown in fig. 3: the invention is mainly used in the field of electrostatic spinning for preparing nano fibers. A strong electric field is formed between the receiving device 10 and the injector 6; the micro-flow injection pump 9 acts on the injector 6 to inject the polymer solution 11 stored in the injector 6 at the flow rate (0.1 mL/h-50/h) required by the electrospinning process, so that the technical core of the injection pump system is to realize accurate control on the motor to achieve high-precision control on the flow rate of the fluid.
Since the injection speed and precision are very high, the stepper motor needs to be driven in a subdivided manner. As a better embodiment, as shown in FIG. 4, an LV8729 motor driving chip of Sanyo semiconductor company is selected, and LV8729 is a high-precision bipolar current type stepping motor control chip. Can output a driving current of up to 1.8A, and supports eight subdivided driving modes of 1, 2, 4, 8, 16, 32, 64 and 128; meanwhile, the chip also has the functions of automatically cutting off current output and giving an alarm when overcurrent and overheat occur; the internal power circuit and the logic circuit share one 24V power supply, which makes the design of the external circuit more concise.
Three pins MD1-MD3 of LV8729 are used for setting the subdivision mode of driving, and considering that the injection speed of the system is preferably controlled to be 0.1-50 mL/h, a 128 subdivision driving mode is adopted, MD1-MD3 are all pulled up to high level, and the stepping angle of the motor is equal to 0.014 degree under the 128 subdivision driving mode.
the magnitude of the drive current of LV8729 is VrefThe potential value of the pin is determined by the sampling resistance on the RF1 and RF2 pins. Output current IoComprises the following steps: i iso＝VrefV (5RF), as a preferred embodiment, the system uses a 42 step motor rated drive current of 1.2A, calculated using a 2W sample resistor of 0.2 ohms, Vref1.2V, obtained by dividing 5V by resistors R6, R7, R8. As a preferred example, R6 is 2.2K, and R7 and R8 are 1K.
In addition, the driving chip also supports automatic half-current locking, the time interval for entering the half-current state is determined by the capacitance value of a capacitor C5 externally connected to the OSC2, and C is selected5When the flow is half-current, 1500pFThe interval was 0.6S. R10 and R11 have the same resistance value, constitute a voltage dividing circuit, and when the drive chip cannot detect step pulse signals every 0.6s, VrefThe voltage is 0.6V, and the driving current is naturally 0.6A, so that the heating value of the stepping motor and the driving system is reduced, and the system stability is improved.
the driving chip OSC1 pin is externally connected with a capacitor C4 for setting current chopping frequency, the current chopping frequency is usually set within the range of 40 kHz-125 kHz, and the higher the switching frequency is, the more serious the heat loss is; the lower the switching frequency, the greater the output drive current ripple. To reduce the heat generation of the driver chip as much as possible, as a preferred embodiment, the chopping frequency is set at 50kHz, and the capacitance of C4 is:
C4＝10×10-6/fcp200 pF. The light emitting diode D1 on the EMO pin is used as an alarm indicator light of the driving system, when the driving chip works normally, the EMO pin is pulled up to high level, and when the chip is over-current, over-heat and the like, the D1 lights up to alarm.
the ST pin of the driving chip is used for controlling the start and stop of the stepping motor, the F/R pin controls the forward and reverse rotation of the motor, and the STP pin receives a pulse signal for controlling the rotating speed of the motor. The control signals are respectively from CLK, DIR and EN pins of the lower computer main control module. The power supply of the main control module is 3.3V, and the voltage of the logic circuit of the driving chip is 5V. As a better embodiment, a P521 type optocoupler of Toshiba company is selected for signal isolation, wherein CLK must be connected with a timer pin of a master control chip, and DIR and EN are connected with a common GPIO port.
The lower computer main control module of the present invention selects stm32f407 of the semiconductor company of the republic of japan as the main control chip, as shown in fig. 5, and in this embodiment, one lower computer main control module controls two micro-fluid injection pumps. Wherein the manual operating button and the limit switch are all triggered as an interrupt event. And the GPIO pin of the connection button is configured to pull up a high level, and a falling edge triggers external interruption to execute manual forward and backward actions. And the GPIO pin connected with the limit switch is configured to be pulled down to a low level, the rising edge triggers external interruption, and the motor is controlled to stop.
The invention utilizes the timer function of stm32 to output pulse signals with fixed frequency to control the stepping motor. And the pulse frequency is related to two factors, namely, a reloading value ARR of the timer and a frequency division factor PSC. The clock frequency of the configured timer is f, the output pulse frequency is f1Comprises the following steps: f. of1f/(ARR +1) (PSC + 1); deducing the solution injection speed V of the systemsThe relationship with the timer reload value ARR is:
Wherein a is the screw pitch of the motor screw rod; r is the radius of the inner wall of the injector; m is the fractional value set for the stepper motor drive.
As a better embodiment, the invention selects a lead screw pitch of 2mm, a motor driver is subdivided into 128 parts, and the frequency division coefficient PSC of a timer is 1499; the timer clock frequency was 84 MHz.
The injection speed of the micro-flow pump can be controlled by controlling the ARR value, but because the micro-flow pump system has errors in operation, the system must be added into a calibration link, and before the system operates every time, V is injected in a trial modexWeighing water (m) with a precision balance of 0.0001g in mlxAnd g. Taking the system calibration coefficient as delta, and then: Δ ═ Vx/mxWhen the system is in a zero error state, Δ is 1. In the experiment, the frequency division coefficient PSC of the timer is taken as a fixed value, and when the delta is larger, the motor rotating speed is slower, so the motor rotating speed is improved in a calibration mode. When Δ is smaller, the motor speed is faster, so the calibration reduces the motor speed. Consider that the ARR value is approximately linear with the calibration factor delta. After the addition of the calibration factor(s),
The micro-fluid pump system uses an MCGS touch screen as an upper computer, calculates and sends a user control instruction, and monitors the running condition of the injection pump system in real time; the stm32 of host computer and lower computer sends control command through the 485 serial ports, and supports one-to-many control mode, and a plurality of miniflow pumps are controlled simultaneously to a host computer promptly. The present embodiment is a micro-fluid pump system with two-in-one configuration, which defines a Modbus communication protocol, and transmits 7 bytes in one communication according to a format of "address code + function code + data length +2 byte data bit + CRC16 check bit", where the address code corresponds to the same address of the main control chip, the function code corresponds to different states of the motor such as positive, negative rotation, stop, and reset, and the data length is 2 bytes, and the data bit is high and low bytes of the operation parameter of the control motor. And finally, CRC16 check is carried out on the data to ensure that the data transmission is accurate. The lower computer receives a '010102 arrH arrL crcH crcL' instruction, and the pump 1 starts to inject solution; receiving a command of '010202 arrH arrL crcH crcL', the pump 1 starts to suck the solution; upon receipt of the "010302 arrH arrL crcH crcL" command, pump 2 begins injecting solution; upon receiving the "010402 arrH arrL crcH crcL" command, pump 2 starts to aspirate solution; receiving an '0105020000 crcH crcL' instruction, the pump 1 stops running; receiving the command of '0106020000 crcH crcL', the pump 2 stops running; wherein manual key adjustments are not available when the system is operating in the automatic operating mode.
As shown in fig. 6, the control flow of the micro fluid pump system includes the following steps:
The method comprises the following steps: before each system is put into operation, V is injected in a trial modexWeighing water (m) with a precision balance of 0.0001g in mlxG, obtaining a system calibration coefficient of delta-Vx/mx。
step two: the user selects the pushing and pulling actions of the injection pump through the upper computer, and sets the injection volume, the solution injection speed and the model of the used injector. The clock frequency f and the frequency division coefficient PSC of the pulse output pin timer of the lower computer stm32 are set to fixed values, and the upper computer calculates the parameter ARR and the timing time t required for single-motor control.
Step three: and judging whether the ARR value obtained by the upper computer exceeds a limit. Since the other parameters of the system are fixed values, ARR and injection speed Vsapproximately inversely proportional. According to the defined Modbus communication protocol, the data bit of a single transmission must not exceed 16 bits, so the range of values of the ARR is: 0 to 65535, in order to generate the pulse waveform, a margin is left on each of the left and right sides, and the lower limit value and the upper limit value of the ARR are respectively set to 10 and 65530, respectively. When the calculated ARR value exceeds the limit, the system alarms and prompts and cannot continue to operate; if the ARR value falls within the limit interval, the following steps can be executed.
Step four: after the operation is started, the upper computer reloads the timer with the value ARR calculated in the third step, the motor positive and reverse states are sent to the lower computer through a 485 serial port, the parameter of the stm32 corresponding to the timer is re-assigned, a required stepping motor driving signal is generated, and the upper computer starts to execute a corresponding cycle strategy when the motor starts to operate: the loop strategy is executed at intervals of 1 second and the remaining injection time is decremented by 1. And when the injection time is cleared, the upper computer sends a motor stop command, and the single injection is finished.
Step five: and step four, in the normal operation of the micro-flow pump, a user suspends the injection pump, the upper computer sends a motor stop command, and meanwhile, a circulation strategy is jumped out to wait for the restart of the injection pump.
The specific embodiments described herein are merely illustrative of the spirit of the invention. Various modifications or additions may be made to the described embodiments or alternatives may be employed by those skilled in the art without departing from the spirit or ambit of the invention as defined in the appended claims.
Claims (10)
1. a micro-flow injection pump system for electrostatic spinning is characterized in that the injection pump system comprises an injection pump, a driving plate, a control plate and an upper computer, the upper computer is communicated with the control plate in an interconnection way, the control plate is respectively connected with a plurality of micro-flow injection pumps through a plurality of driving plates,
The micro-flow injection pump comprises a screw rod (1), a stepping motor (2), a guide rail (3), a sliding table (4) and an injection pump body (5), wherein the screw rod (1), the stepping motor (2) and the guide rail (3) are all arranged in the injection pump body (5), and the micro-flow injection pump is characterized in that: the guide rail (3) is arranged at the bottom, the stepping motor (2) is arranged at one end of the guide rail (3), and the screw rod (1) is fixed on the stepping motor (2) and rotates along with the operation of the stepping motor (2); the injector (6) is fixed on the injection pump body (5) through a bracket; the upper part of the sliding table (4) is fixedly connected with the tail part of a movable plug (6-1) of the injector (6), the lower part of the sliding table (4) is provided with a threaded hole which is matched and sleeved on the screw rod (1), and the bottom of the sliding table (4) is arranged on the guide rail (3);
The stepping motor (2) works to drive the screw rod (1) to rotate, the screw rod (1) enables the sliding table (4) to be pushed or pulled back on the guide rail (3) based on a threaded hole of the sliding table (4), and the pushing and pulling-back process of the sliding table (4) provides power for the movable plug (6-1) of the injector (6) to realize injection or liquid taking.
2. The micro-fluid injection pump system for electrostatic spinning according to claim 1, wherein a left limit optical coupler (7-1) and a right limit optical coupler (7-2) are respectively arranged at two ends of the screw rod (1) in the injection pump body (5).
3. microfluidic syringe pump system for electrospinning according to claim 1, characterized in that the syringe pump body (5) is externally provided with a forward button (8-1) and a backward button (8-2) for controlling the forward and backward rotation of the stepper motor (2), respectively.
4. A micro-fluid injection pump system for electrostatic spinning according to claim 1, wherein the driving board is LV8729 motor driving chip of ocean semiconductor company, and MD1-MD3 pins of LV8729 chip are all pulled high to realize 128-segment driving mode.
5. The microfluidic syringe pump system according to claim 4, wherein the LV8729 chip supports automatic half-flow locking, the OSC2 pin is grounded via a capacitor C5, and the capacitance of C5 determines the time interval of entering the half-flow state; the VREF pin of the LV8729 chip is connected to the resistor R10, and to the DOWN pin through the resistor R11, where R10 is R11.
6. The microfluidic syringe pump system for electrospinning of claim 4, wherein the OSC1 pin of the LV8729 chip is grounded through a capacitor C4, and C5 is used to set the current chopping frequency.
7. The micro-fluid injection pump system for electrostatic spinning according to claim 1, wherein the control board is stm32, and the control board outputs a pulse signal with a fixed frequency based on the timer function of stm32 to control the liquid taking or injection speed of the injector.
8. microfluidic injection pump system for electrospinning according to claim 7, wherein the liquid extraction or injection speed VsThe relationship with the timer reload value ARR is:
in the formula, a is the screw pitch of a motor screw rod; r is the radius of the inner wall of the injector; m is a fine value set by the driving of the stepping motor; PSC is a frequency division coefficient of a timer;
Controlling the liquid taking or injection speed V of the micro-fluid injection pump system by controlling the ARR values。
9. Microfluidic injection pump system for electrospinning according to claim 8, wherein the liquid extraction or injection speed VsThe control process of (2) further comprises a calibration step, wherein the calibration step is to test the injection V before the system runs every timexWeighing the distilled water with mass m by a precision balancexG; after the calibration step is added, the liquid is taken or the injection speed V is measuredsThe relationship with the timer reload value ARR is:
Wherein Δ ═ Vx/mx。
10. A micro-fluid injection pump system for electrostatic spinning according to claim 1, wherein the upper computer corresponds to one or more injection pumps, the upper computer sends control commands to the control board through 485 bus to define Modbus communication protocol, data transmission transmits 7 bytes at a time according to the format of "address code + function code + data length +2 byte data bit + CRC16 check bit", wherein the address code corresponds to the same main control chip address respectively, the function code corresponds to different states of the motor including positive, reverse, stop and reset, the data length is 2 bytes, and the data bit is high and low byte of control motor operation parameter; the CRC16 check ensures that the data transfer is accurate.
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