CN110544535A - Turner syndrome bone health evaluation system and establishment method thereof - Google Patents
Turner syndrome bone health evaluation system and establishment method thereof Download PDFInfo
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- CN110544535A CN110544535A CN201910681425.6A CN201910681425A CN110544535A CN 110544535 A CN110544535 A CN 110544535A CN 201910681425 A CN201910681425 A CN 201910681425A CN 110544535 A CN110544535 A CN 110544535A
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- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
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Abstract
The invention relates to a Turner syndrome bone health evaluation system and an establishment method thereof. The establishing method comprises the steps of setting a plurality of parameter acquisition units, setting a parameter processing unit, setting a judging unit, setting an output unit and the like. According to the invention, through quantitative ultrasonic detection data of bones obtained by applying an ultrasonic bone densitometer to dozens of TS patients, the positive and negative correlation between the ultrasonic propagation speed and amplitude attenuation of the TS patients and the age is found, and the correlation between the TS patients and chromosome karyotype is not found. Further research shows that other data results are similar to bone quantitative ultrasonic detection data feedback results, certain correlation is found with bone density of TS patients, and different influences are caused on bone health states of the TS patients. The research results are combined, and a multi-azimuth and multi-system TS bone health evaluation system is established by combining the detection advantages and disadvantages of an X-ray absorption measurement method, an ultrasonic measurement method, CT and the like, and is particularly important for establishing an early intervention early treatment medical mode aiming at TS bone health decline.
Description
Technical Field
The invention relates to the field of disease health state evaluation, in particular to a Turner syndrome bone health evaluation system and an establishment method thereof.
Background
research shows that the risk of bone fracture of patients with TS (Turner's Syndrome) is 25% higher than that of normal people, and how to scientifically evaluate the bone health of patients with TS to reduce osteoporosis is a focus of attention in the industry. At present, bone quality evaluation results of TS patients are different, and students find that bone density (BMD) of cortical bone and cancellous bone of the TS patients is different by applying a dual-energy X-ray absorptiometry (DEXA) study, and reports also report that the results are unchanged. It has been reported that the abnormal microstructure and strength of each bone of TS patients compared with those of normal population can be observed by high resolution Quantitative Computer Tomography (QCT), which is the cause of the increased incidence of fracture in TS patients. However, there are several studies that have shown that low BMD in TS subjects detected by dual energy X-ray absorptiometry has certain limitations because, based on the effect of body type on areal BMD (abmd), smaller bones are less dense on the measurement surface than larger bones, resulting in lower T-and Z-scores in short individuals. In fact, when considering the bone size reduction, TS subjects with obvious BMD defects will be reduced. The development of new bone imaging diagnostics, as peripheral quantitative computed tomography (pQCT), allows assessment of bone geometry and bone compartment characteristics in TS subjects. Indeed, pQCT can provide an accurate measurement of three-dimensional bone density without being affected by bone size, and can independently assess trabecular and cortical bone density. In this regard, low cortical bone density, significant thinning of cortical bone, normal trabecular bone BMD of the radius were observed in TS adolescents using pQCT, and similar results were found in TS young adults. These findings indicate that selective reduction of cortical bone may adversely affect biomechanics and predispose TS subjects to bone fracture and fractures. There are studies reporting that decreased bone health in TS patients correlates with muscle strength, and that in TS patients of the same muscle strength, bone strength is lower compared to the normal population.
because the traditional bone health evaluation indexes and results of patients with Turner syndrome are more divergent, an evaluation system with relatively reliable results for evaluating the bone health condition of patients with Turner syndrome does not exist at present.
disclosure of Invention
Based on this, there is a need for a Turner syndrome bone health assessment system and a method for establishing the same, which is advantageous for improving the reliability of results.
a method for establishing a bone health evaluation system of Turner syndrome comprises the following steps:
Setting a plurality of parameter acquisition units, wherein the parameter acquisition units are used for respectively acquiring bone quantitative ultrasonic detection data, micro-CT detection data, dual-energy X-ray bone densitometer detection data, body composition determination data, muscle information data and quantized life style data of a TS patient;
A parameter processing unit is arranged and used for carrying out data processing on the data acquired by the plurality of parameter acquisition units;
Setting a judging unit, wherein the judging unit is used for comparing and analyzing the data processing result of the parameter processing unit and preset parameters to obtain bone health state information of the TS patient;
And an output unit is arranged and used for outputting and displaying the bone health state information of the TS patient.
In one embodiment, the bone quantitative ultrasound test data includes at least one of a bone density parameter, a bone hardness parameter, an ultrasound propagation velocity parameter, and an amplitude attenuation parameter.
In one embodiment, the micro-CT detection data includes bone morphology parameters.
in one embodiment, the dual energy X-ray bone densitometer detection data comprises a bone density parameter.
In one embodiment, the body composition measurement data includes body composition parameters.
In one embodiment, the body composition parameter comprises a muscle content parameter.
In one embodiment, the muscle information data comprises muscle strength parameters.
In one embodiment, the quantified lifestyle data includes daily milk consumption, exercise hours, and outdoor exposure hours.
In one embodiment, the parameter processing unit normalizes the data acquired by the plurality of parameter acquiring units, and performs data weighting calculation processing according to preset weights respectively.
A bone health evaluation system for Turner syndrome is established by adopting the establishment method in any embodiment.
The invention finds that the ultrasonic propagation speed and the amplitude attenuation of the TS patient respectively have positive and negative correlations with age and have no correlation with chromosome karyotype through the quantitative ultrasonic bone detection data obtained by applying the ultrasonic bone densitometer to dozens of TS patients, such as parameter data of bone density, bone hardness, ultrasonic propagation speed (SOS), amplitude attenuation (BUA) and the like. Further researching the results of microscopic CT detection data (such as bone shape parameters), dual-energy X-ray bone densitometer detection data (such as bone density parameters), body composition determination data (such as body composition parameters including muscle content parameters), muscle information data (such as muscle strength parameters) and quantitative life style data (such as daily milk intake, exercise duration and outdoor sunshine duration) are similar to the feedback results of bone quantitative ultrasonic detection data, and the results of microscopic CT detection data and dual-energy X-ray bone densitometer detection data are all found to have certain correlation with the bone density of a TS patient and have different influences on the bone health state of the TS patient. The research results are combined, and a multi-directional and multi-system TS bone health evaluation system is established by combining the detection advantages and disadvantages of a dual-energy X-ray absorption measurement method, an ultrasonic bone densitometry method, CT and the like, and is particularly important for establishing an early intervention early treatment medical mode aiming at TS bone health decline. The establishment of the Turner syndrome bone health evaluation system provides a theoretical and clinical evaluation basis for clinically establishing a modern 4P medical (predictive; intervention; personalized; active participation) management and transformation medical mode which is based on bone health management under the guidance of gene CNV and mainly prevents bone metabolic abnormality.
Drawings
FIG. 1 is a schematic flow chart illustrating a method for establishing a Turner syndrome bone health assessment system according to an embodiment;
Fig. 2 is a schematic block structure diagram of the established Turner syndrome bone health evaluation system.
Detailed Description
To facilitate an understanding of the invention, the invention will now be described more fully with reference to the accompanying drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
As shown in fig. 1, an embodiment of the present invention provides a method for establishing a bone health evaluation system for Turner syndrome, which includes the following steps:
Step S110: setting a plurality of parameter acquisition units, wherein the parameter acquisition units are used for respectively acquiring bone quantitative ultrasonic detection data, micro-CT detection data, dual-energy X-ray bone densitometer detection data, body composition determination data, muscle information data and quantized life style data of a TS patient;
Step S120: a parameter processing unit is arranged and used for carrying out data processing on the data acquired by the plurality of parameter acquisition units;
Step S130: the judging unit is arranged and used for comparing and analyzing the data processing result of the parameter processing unit and preset parameters to obtain bone health state information of the TS patient;
Step S140: and an output unit is arranged and used for outputting and displaying the bone health state information of the TS patient.
in the embodiment, TS patients are diagnosed by collection, each parameter of the patients is measured by bone quantitative ultrasound, each bone microstructure is observed by micro-CT, bone morphological parameters are measured, the bone density is measured by a DPX-L type dual-energy X-ray bone densitometer not limited to Lunar corporation in the United states, body components are measured by a biological resistance measurement method, such as muscle content measurement, muscle strength is measured by a force measuring instrument not limited to the muscle strength, the life style of the patients is collected, evaluated and quantified, and finally, the bone health can be evaluated in multiple directions by a weighted scoring system. Aiming at the predicted risk, the knowledge of gene-environment interaction is fully utilized, the environmental factors influencing the expression and regulation of the susceptible gene are grasped, and the purposes of regulating the gene expression and recovering the normal physiological balance are achieved by changing external environmental factors such as physical exercise, enough vitamin D and calcium intake, related hormone treatment and the like. Establishing a modern 4P medical management and transformation medical mode mainly for preventing bone metabolism abnormality, including early prediction, early intervention, early personalized medicine and early active participation.
Specifically, in one example, the bone quantitative ultrasonic testing data includes at least one of a bone density parameter, a bone hardness parameter, an ultrasonic propagation velocity parameter and an amplitude attenuation parameter, and preferably includes four parameters of the bone density parameter, the bone hardness parameter, the ultrasonic propagation velocity parameter and the amplitude attenuation parameter.
in one particular example, the micro-CT examination data includes bone morphology parameters.
In one particular example, the dual energy X-ray bone densitometer detection data includes a bone density parameter.
in one particular example, the body composition measurement data includes body composition parameters. Preferably, the body composition parameter includes a muscle content parameter.
In one particular example, the muscle information data includes muscle strength parameters.
In one particular example, the quantified lifestyle data includes daily milk consumption, length of exercise, and length of outdoor exposure. The daily milk amount is preferably high-calcium milk which is sold by citing various types; the movement duration can be the sum of the time of various movements; the outdoor sunshine duration is preferably a sunshine duration in sunny days.
in a specific example, the parameter processing unit normalizes the data acquired by the plurality of parameter acquiring units, and performs data weighting calculation processing according to preset weights respectively.
For example, in a more specific example, by detecting bone health conditions of tens of TS patients and comprehensively evaluating the above-mentioned multiple items of detection data of patients whose bone health is evaluated as abnormal or normal, it is found that when the TS patients account for 50% of the dual-energy X-ray bone densitometer detection data, the micro-CT detection data, and the bone quantitative ultrasound detection data (wherein, preferably, the dual-energy X-ray bone densitometer detection data accounts for 20%, the micro-CT detection data accounts for 15%, and the bone quantitative ultrasound detection data accounts for 15%), the body composition measurement data accounts for 20%, the muscle information data accounts for 20%, and the quantized lifestyle data accounts for 10%, the evaluation result of the multi-azimuth multi-system TS patient bone health evaluation system established is most accurate and reliable. It can be understood that, considering the individual difference of different TS patients, the actual judgment can be preferably combined with CNV (gene copy number variation) to carry out auxiliary judgment, and the result is more accurate and reliable.
the invention also provides a Turner syndrome bone health evaluation system which is established by adopting the establishment method.
Specifically, as shown in fig. 2, the Turner syndrome bone health evaluation system 200 includes a parameter obtaining unit 210, a parameter processing unit 220, a determining unit 230, and an output unit 240. The parameter processing unit 220 is configured to perform data processing on the parameters acquired by the parameter acquiring unit 210; the judging unit 230 is configured to compare and analyze the data processing result of the parameter processing unit 220 with a preset parameter to obtain bone health status information of the TS patient; the output unit 240 is used for outputting and displaying the bone health status information of the TS patient.
more specifically, the parameter acquisition unit 210 includes an ultrasound data acquisition unit 211, a CT data acquisition unit 212, an X-ray data acquisition unit 213, a body composition data acquisition unit 214, a muscle information data acquisition unit 215, and a lifestyle data acquisition unit 216. The ultrasonic data acquisition unit 211 is used for or bone quantitative ultrasonic detection data of the TS patient; a CT data acquisition unit 212 for acquiring micro CT detection data of the TS patient; the X-ray data acquisition unit 213 is configured to acquire detection data of the dual-energy X-ray bone densitometer; a body composition data acquisition unit 214 for acquiring body composition measurement data; the muscle information data obtaining unit 215 is configured to obtain muscle information data; the lifestyle data acquisition unit 216 is configured to acquire quantized lifestyle data.
The bone quantitative ultrasonic detection data comprises at least one of a bone density parameter, a bone hardness parameter, an ultrasonic propagation speed parameter and an amplitude attenuation parameter, and preferably comprises four parameters of the bone density parameter, the bone hardness parameter, the ultrasonic propagation speed parameter and the amplitude attenuation parameter. The micro-CT examination data includes bone morphology parameters. The detection data of the dual-energy X-ray bone densitometer comprises bone density parameters. The body composition measurement data comprises body composition parameters, and preferably, the body composition parameters comprise muscle content parameters. The muscle information data includes muscle strength parameters. The quantified lifestyle data includes daily milk consumption, exercise duration, and outdoor sunshine duration.
The invention also provides a Turner syndrome bone health assessment computer device which is provided with a processor, a memory and a Turner syndrome bone health assessment program which is stored on the memory and can run on the processor. The processor executes the Turner syndrome bone health evaluation program according to the workflow of the modules in the Turner syndrome bone health evaluation system 200.
In one particular example, the Turner syndrome bone health assessment computer apparatus further comprises an input device, the input device being electrically connected to the processor.
In one particular example, the Turner syndrome bone health assessment computer device further comprises a display device, the display device being electrically connected with the processor.
In one specific example, the Turner syndrome bone health assessment computer device further comprises a printing device, the printing device being electrically connected with the processor.
Further, the invention also provides a Turner syndrome bone health evaluation computer readable storage medium, on which a computer program is stored. The computer program is a Turner syndrome bone health assessment program. The computer program is executed by the processor according to the workflow of the modules of the Turner syndrome bone health assessment system 200.
The Turner syndrome bone health evaluation system, the computer equipment and the readable storage medium can automatically evaluate the bone health of various Turner syndromes without manual operation, and have high calculation efficiency and high accuracy.
Through quantitative bone ultrasonic detection data obtained by applying an ultrasonic bone densitometer to dozens of TS patients, such as parameter data of bone density, bone hardness, ultrasonic propagation velocity (SOS) and amplitude attenuation (BUA), the TS patients are found to have positive and negative correlations with the ages and no correlation with chromosome karyotypes. Further research on microscopic CT detection data (such as bone shape parameters), dual-energy X-ray bone densitometer detection data (such as bone density parameters), body composition measurement data (such as body composition parameters including muscle content parameters), muscle information data (such as muscle strength parameters) and quantized life style data results are similar to bone quantitative ultrasonic detection data feedback results, and the results show that the results have certain correlation with the bone density of a TS (transport stream) patient and have different influences on the bone health state of the TS patient.
The research results are combined, and a multi-directional and multi-system TS bone health evaluation system is established by combining the detection advantages and disadvantages of a dual-energy X-ray absorption measurement method, an ultrasonic bone densitometry method, CT and the like, and is particularly important for establishing an early intervention early treatment medical mode aiming at TS bone health decline. The establishment of the Turner syndrome bone health evaluation system provides a theoretical and clinical evaluation basis for clinically establishing a modern 4P medical (predictive; intervention; personalized; active participation) management and transformation medical mode which is based on bone health management under the guidance of gene CNV and mainly prevents bone metabolic abnormality.
the technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. A method for establishing a bone health evaluation system of Turner syndrome is characterized by comprising the following steps:
Setting a plurality of parameter acquisition units, wherein the parameter acquisition units are respectively used for acquiring bone quantitative ultrasonic detection data, micro-CT detection data, dual-energy X-ray bone densitometer detection data, body composition determination data, muscle information data and quantized life style data of a TS patient;
A parameter processing unit is arranged and used for carrying out data processing on the data acquired by the plurality of parameter acquisition units;
The judging unit is used for comparing and analyzing the data processing result of the parameter processing unit with preset parameters and outputting bone health state information of the TS patient;
And an output unit is arranged and used for outputting and displaying the bone health state information of the TS patient.
2. The method of establishing a Turner syndrome bone health assessment system of claim 1, wherein said bone quantitative ultrasound test data comprises at least one of a bone density parameter, a bone hardness parameter, an ultrasound propagation velocity parameter and an amplitude attenuation parameter.
3. The method of establishing a Turner syndrome bone health assessment system of claim 1, wherein said micro-CT detection data comprises bone morphology parameters.
4. The method of establishing a Turner syndrome bone health assessment system of claim 1, wherein the dual energy X-ray bone densitometer detection data comprises a bone density parameter.
5. The method of establishing a Turner syndrome bone health assessment system of claim 1, wherein said body composition measurement data comprises body composition parameters.
6. The method of establishing a Turner syndrome bone health assessment system of claim 5, wherein the body composition parameter comprises a muscle content parameter.
7. The method for establishing a Turner syndrome bone health assessment system of claim 1, wherein the muscle information data comprises muscle strength parameters.
8. The method of establishing a Turner syndrome bone health assessment system of claim 1, wherein said quantified lifestyle data includes daily milk intake, exercise duration, and outdoor exposure duration.
9. The method for establishing the Turner syndrome bone health evaluation system of any one of claims 1-8, wherein the parameter processing unit normalizes the data acquired by the plurality of parameter acquisition units, and performs data weighting calculation processing according to preset weights respectively.
10. a Turner syndrome bone health assessment system, characterized by being established by the establishment method as set forth in any one of claims 1 to 9.
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