CN110542719B - Detection method of tissue-imitated body model - Google Patents
Detection method of tissue-imitated body model Download PDFInfo
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/04—Analysing solids
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- G—PHYSICS
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- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
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- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/04—Analysing solids
- G01N29/07—Analysing solids by measuring propagation velocity or propagation time of acoustic waves
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
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- G01N29/30—Arrangements for calibrating or comparing, e.g. with standard objects
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N5/00—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid
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Abstract
The invention discloses a detection method of a tissue-imitated phantom, which comprises the following steps: weighing the tissue phantom, comparing the weighing result with the nominal weight of the tissue phantom, and carrying out ultrasonic detection on the tissue phantom if the measured result deviates from the nominal weight and is less than a preset value; wherein the performing ultrasonic testing on the tissue phantom comprises: and obtaining ultrasonic data of the tissue phantom, and judging whether the tissue phantom is abnormal or not according to the ultrasonic data. According to one embodiment of the disclosure, the internal condition of the tissue phantom can be judged, so as to judge whether the tissue phantom can support the continuous use and the continuous storage. The consistency and the accuracy of the tissue phantom imitation in the using process are ensured, and the method can be used in the tissue phantom imitation quality monitoring link.
Description
Technical Field
The invention relates to the field of detection, in particular to a detection method of a tissue-imitated phantom for calibrating and testing an ultrasonic instrument.
Background
In the research and development and use process of the ultrasonic elastography instrument, on one hand, the working effect of the instrument needs to be detected, and on the other hand, the instrument needs to be calibrated due to the aging of the instrument and other reasons. The tissue-imitated body model is a reference sample for detecting and calibrating ultrasonic detection equipment. The tissue-imitating body model is an indispensable tool in the production and quality control links of equipment.
Tissue phantoms are of a wide variety, including gelatin, agar, or other polymeric materials. In view of the characteristics of the tissue phantom itself, the conditions for its use and preservation are relatively stringent. However, the tissue-imitated phantom is unstable in property and is easy to change along with the change of the environmental temperature and humidity; and the cost of the tissue phantom is expensive, and if the tissue phantom is in a problem, the calibration and the test of the ultrasonic detection equipment are influenced.
Therefore, how to store the tissue-mimicking phantom, how to prolong the service life of the tissue-mimicking phantom, how to check the tissue-mimicking phantom, and how to ensure normal use of the tissue-mimicking phantom play an important role in equipment production and quality control.
Disclosure of Invention
The invention aims to provide a novel technical scheme of a detection method of a tissue-imitated body model.
According to a first aspect of the invention there is provided a method of detection of a mock tissue phantom comprising:
weighing the tissue phantom, comparing the weighing result with the nominal weight of the tissue phantom, and carrying out ultrasonic detection on the tissue phantom if the measured result deviates from the nominal weight and is less than a preset value;
wherein the ultrasonic detection of the tissue phantom comprises:
obtaining ultrasound data of the phantom, and
and judging whether the tissue-imitated body model is abnormal or not according to the ultrasonic data.
Optionally, the anomaly comprises a non-uniform scatterer distribution, the presence of a strongly reflecting region, a crack, a void, or a rate of change of acoustic velocity greater than a threshold.
Optionally, an ultrasound image of the simulated tissue phantom is constructed according to the ultrasound data, and a judgment is made according to whether the ultrasound image is abnormal.
Optionally, the ultrasound data is the sound velocity of the tissue phantom, and the determination is performed according to the change rate of the sound velocity and the nominal sound velocity of the tissue phantom.
Optionally, the rate of change of the speed of sound n of the simulated tissue phantom is calculated according to the following formula:
d t for measuring the vertical distance from the upper surface to the lower surface of the tissue phantom, d 1 For calibrationThe vertical distance from the upper surface to the lower surface of the tissue phantom is simulated;
and when the sound velocity change rate n of the tissue simulating phantom is larger than a preset value, returning the tissue simulating phantom to the factory for maintenance or scrapping.
Optionally, the performing ultrasound detection on the simulated tissue phantom comprises performing a first ultrasound measurement and a second ultrasound measurement; and constructing an ultrasonic image of the tissue phantom according to the ultrasonic data obtained by the first ultrasonic measurement, and judging whether the ultrasonic image is abnormal or not.
And obtaining the sound velocity of the tissue-imitated body model according to the second ultrasonic measurement, and judging according to the change rate of the sound velocity.
Optionally, in the weighing step, the ultrasound step is performed when the weight gain or loss of the mock tissue phantom is less than a first predetermined value.
Optionally, the mock tissue phantom is stored in a dehumidified state when the weight of the mock tissue phantom increases by less than a first predetermined value and greater than a second predetermined value.
Optionally, the mock tissue phantom is stored humidified when the weight loss of the mock tissue phantom is less than a first predetermined value and greater than a second predetermined value.
Optionally, the first predetermined value is 2%.
Optionally, the second predetermined value is 1%.
Optionally, the current air is humidified, or a moisture-retaining layer is attached to the surface of the phantom.
Optionally, before the weighing step and the ultrasonic step, an appearance inspection step is further included.
Alternatively, the detection method is performed every predetermined time.
Optionally, each execution of the detection method is performed at the same temperature.
According to one embodiment of the disclosure, the internal condition of the tissue phantom can be judged, so as to judge whether the tissue phantom can support the continuous use and the continuous storage. The consistency and the accuracy of the tissue phantom imitation in the use process are ensured, and the method can be used for the tissue phantom imitation quality monitoring link.
Other features of the present invention and advantages thereof will become apparent from the following detailed description of exemplary embodiments thereof, which proceeds with reference to the accompanying drawings.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description, serve to explain the principles of the invention.
FIG. 1 is a schematic diagram of a first embodiment of the detection method of the present invention.
FIG. 2 is a schematic diagram of a second embodiment of the detection method of the present invention.
FIG. 3 is a schematic diagram of a third embodiment of the detection method of the present invention.
Detailed Description
Various exemplary embodiments of the present invention will now be described in detail with reference to the accompanying drawings. It should be noted that: the relative arrangement of the components and steps, the numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless it is specifically stated otherwise.
The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the invention, its application, or uses.
Techniques, methods, and apparatus known to one of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate.
In all examples shown and discussed herein, any particular value should be construed as merely illustrative, and not limiting. Thus, other examples of the exemplary embodiments may have different values.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, further discussion thereof is not required in subsequent figures.
The invention provides a detection method of a tissue-imitated phantom (called the tissue-imitated phantom for short), which can obtain whether the tissue-imitated phantom is abnormal or not, and when the tissue-imitated phantom is abnormal, the tissue-imitated phantom no longer meets the condition of continuous use and needs to be returned to a factory for maintenance or scrapped.
Fig. 1 shows a first embodiment of the detection method of the present invention. Referring to fig. 1, the invention provides a method for detecting a tissue phantom, comprising weighing the tissue phantom, comparing the weighing result with the nominal weight of the tissue phantom, and performing ultrasonic detection on the tissue phantom if the measured result deviates from the nominal weight by less than a predetermined value; wherein the performing ultrasonic testing on the tissue phantom comprises: and obtaining ultrasonic data of the tissue phantom, and judging whether the tissue phantom is abnormal or not according to the ultrasonic data.
Firstly, weighing and recording the simulated tissue body membrane, comparing the weighed weight with the nominal weight of the simulated tissue body membrane, and carrying out ultrasonic detection on the simulated tissue body membrane if the measured result deviates from the nominal weight and is less than a preset value; if the simulated tissue membrane is larger than the preset value, the simulated tissue membrane can be considered to not meet the conditions of continuous storage and continuous use, and can be returned to a factory for maintenance or scrapped.
The nominal weight of the invention can be the weight marked when the tissue phantom leaves a factory or the original weight measured when the tissue phantom arrives at a commodity.
In a specific embodiment of the invention, when the measured weight of the simulated tissue body membrane deviates from its nominal value by more than a first predetermined value (for example, 2%), the simulated tissue body membrane changes too much and its interior has changed too much to satisfy the conditions for continued storage and use, and needs to be returned to the factory. If the deviation from its nominal value is less than a first predetermined value (e.g., 2%), it is assumed that the simulated tissue body membrane can continue to be used, continue to be stored, and the step of ultrasound detection is performed.
Of course, the first predetermined value is not limited to the above-mentioned embodiment, and can be set by those skilled in the art according to actual needs.
In an alternative embodiment of the invention, when the weight of the mock tissue phantom increases less than a first predetermined value (e.g., 2%) and greater than a second predetermined value (e.g., 1%), indicating an increase in the weight of the mock tissue phantom, the mock tissue phantom may need to be stored dehumidified. The air in the storage environment may be dehumidified, for example, by dehumidification equipment well known to those skilled in the art, to reduce the humidity inside the phantom, reducing the weight of the phantom. Alternatively, a material that can reduce moisture may be placed in contact with the surface of the phantom, such as a sponge or other material known to those skilled in the art.
Of course, the first predetermined value is not limited to the above-mentioned embodiment, and can be set by those skilled in the art according to actual needs.
In an alternative embodiment of the invention, when the weight loss of the mock tissue phantom is less than a first predetermined value (e.g., 2%) and greater than a second predetermined value (e.g., 1%), this indicates that the weight of the mock tissue phantom has decreased, requiring humidified storage of the mock tissue phantom. The air in the storage environment may be humidified, for example, by humidification equipment well known to those skilled in the art, to increase the humidity inside the phantom, increasing the weight of the phantom. Alternatively, a material that can increase the humidity is contacted with the surface of the phantom, such as a wet sponge, aqueous latex, or the like, as is known to those skilled in the art.
And after the weighed tissue-mimicking phantom meets the conditions of continuous storage and continuous use, detecting the interior of the tissue-mimicking phantom by using ultrasonic waves to obtain ultrasonic data of the tissue-mimicking phantom, and judging whether the tissue-mimicking phantom is abnormal or not according to the ultrasonic data.
Anomalies in the present invention include, but are not limited to, non-uniform scatterer distribution, presence of strongly reflecting regions, cracks, voids, or a rate of change of acoustic velocity greater than a threshold value.
When ultrasonic detection is carried out, the tissue phantom and the ultrasonic probe need to be placed on a special jig, the distance between the ultrasonic probe and the surface of the tissue phantom is 5mm, and the ultrasonic probe and the tissue phantom can be coupled by adopting distilled water. The ultrasonic probe is perpendicular to the surface of the tissue phantom. During detection, the angle of the ultrasonic probe can be adjusted to enable the reflected signals on the surface and the bottom of the tissue phantom to be strongest.
In an alternative embodiment of the invention, an ultrasound image of the mock tissue phantom is constructed from the ultrasound data, and a determination is made as to whether an abnormality exists in the ultrasound image. For example, a B-mode ultrasound imaging mode, a record acquisition mode selection and a gain selection may be selected. Whether the scatterers in the tissue phantom are uniformly distributed and whether obvious strong reflection areas, cracks or cavities occur can be observed through B-ultrasonic imaging, and if the abnormal phenomena are found, the tissue phantom is returned to the factory for maintenance or scrapped.
In an optional embodiment of the present invention, the ultrasound data is a sound velocity of the tissue phantom, and the determination is performed according to a rate of change of the sound velocity from a nominal sound velocity of the tissue phantom. When the change rate of the sound velocity is too large, the inside of the sound velocity is changed too much, the conditions of continuous storage and continuous use are not met, and the sound velocity needs to be returned to a factory. For example, if the sound velocity change rate is less than 5%, the simulated tissue membrane can be used and stored continuously.
The nominal sound velocity of the invention can be the sound velocity marked when the tissue phantom leaves the factory or the original sound velocity measured when the tissue phantom arrives at the goods.
In an alternative embodiment of the invention, the rate of change of the speed of sound n for the tissue phantom is calculated according to the following formula:
wherein dt is the measured vertical distance from the upper surface to the strong reflection position of the lower surface of the tissue phantom, and d1 is the calibrated vertical distance from the upper surface to the lower surface of the tissue phantom; and when the sound velocity change rate n of the tissue-imitated body model is greater than a preset value, returning the tissue-imitated body model to the factory for maintenance or scrapping.
For example, a B-ultrasonic testing mode can be adopted, the probe angle is adjusted to enable the reflection signals of the surface and the bottom of the tissue-imitated phantom to be strongest, so that the vertical distance dt from the upper surface to the strong reflection part of the lower surface of the tissue-imitated phantom is measured, the sound velocity change rate of the tissue-imitated phantom is obtained through calculation, if the sound velocity change rate is too large, the tissue-imitated phantom is considered to be changed too much, the tissue-imitated phantom is considered to not meet the conditions of continuous use and continuous storage, and the tissue-imitated phantom needs to be returned to a factory for maintenance or scrapped.
When ultrasonic detection is carried out to obtain ultrasonic data, A ultrasonic, B ultrasonic and M ultrasonic can be selected. Each phantom may take several points, e.g., 9 points of data, and each point may take several sets of data, e.g., 20 sets of data for calculation.
Fig. 2 shows another embodiment of the detection method of the present invention. In the embodiment shown in fig. 2, the ultrasound examination of the mock tissue phantom comprises a first ultrasound examination and a second ultrasound examination. The sequence of the first ultrasonic detection and the second ultrasonic detection is not limited, and the first ultrasonic detection can be carried out first, and then the second ultrasonic detection can be carried out; or the second ultrasonic detection can be carried out first, and then the first ultrasonic detection is carried out.
In the first ultrasonic detection, an ultrasonic image of the tissue phantom is constructed according to ultrasonic data obtained by the first ultrasonic detection, and whether the ultrasonic image is abnormal or not is judged.
For example, a B-mode ultrasound imaging mode, a record acquisition mode selection, and a gain selection may be selected. Whether the scatterers in the tissue phantom are uniformly distributed and whether obvious strong reflection areas, cracks or cavities occur can be observed through B-ultrasonic imaging, and if the abnormal phenomena are found, the tissue phantom is returned to the factory for maintenance or scrapped.
In the second ultrasonic detection, the sound velocity of the tissue phantom is obtained according to the second ultrasonic detection, and judgment is carried out according to the change rate of the sound velocity. When the change rate of the sound velocity is too large, the inside of the sound velocity is changed too much, the conditions of continuous storage and continuous use are not met, and the sound velocity needs to be returned to a factory. For example, if the speed of sound changes less than 5%, the tissue-like membrane can be used and stored continuously.
The nominal sound velocity of the invention can be the sound velocity marked when the tissue phantom leaves the factory or the original sound velocity measured when the tissue phantom arrives at the goods.
In an alternative embodiment of the invention, the rate of change of the speed of sound n for the tissue phantom is calculated according to the following formula:
wherein d is t For measuring the vertical distance from the upper surface to the strong reflection position of the lower surface of the tissue phantom, d 1 The vertical distance from the upper surface to the lower surface of the calibrated tissue-imitated body model is obtained; and when the sound velocity change rate n of the tissue-imitated body model is greater than a preset value, returning the tissue-imitated body model to the factory for maintenance or scrapping.
For example, a B-ultrasonic testing mode can be adopted, the probe angle is adjusted to enable the reflection signals of the surface and the bottom of the tissue-imitated phantom to be strongest, so that the vertical distance dt from the upper surface to the strong reflection part of the lower surface of the tissue-imitated phantom is measured, the sound velocity change rate of the tissue-imitated phantom is obtained through calculation, if the sound velocity change rate is too large, the tissue-imitated phantom is considered to be changed too much, the tissue-imitated phantom is considered to not meet the conditions of continuous use and continuous storage, and the tissue-imitated phantom needs to be returned to a factory for maintenance or scrapped.
When ultrasonic detection is carried out to obtain ultrasonic data, A ultrasonic, B ultrasonic and M ultrasonic can be selected. Each phantom may take several points, e.g., 9 points of data, and each point may take several sets of data, e.g., 20 sets of data, for calculation.
Fig. 3 shows a third embodiment of the detection method of the invention. In the embodiment shown in FIG. 3, the step of performing an appearance check on the phantom is also included prior to weighing and ultrasonically detecting the phantom.
In the appearance inspection step, whether the appearance of the tissue phantom is normal or not, whether the surface and the shell of the tissue phantom are damaged or sunken or not and whether liquid flows out or not can be inspected, if the tissue phantom is damaged or the liquid flows out, the damaged tissue phantom is not directly contacted with the tissue phantom by hands, and the damaged tissue phantom is sealed in a sealing bag by wearing latex gloves; the damaged tissue-imitated phantom cannot be discarded by self, and needs to be sealed and returned to a manufacturer for centralized treatment by the manufacturer; after the hands or other parts contact the damaged tissue-imitating body model, the eyes are washed by clear water as soon as possible, and the skin surface is cleaned by soapy water; the table surface which is damaged and polluted by the imitation tissue phantom is cleaned by soapy water.
The steps of weighing and ultrasonic testing the tissue phantom in the embodiment shown in fig. 3 are the same as those in the embodiments shown in fig. 1 and 2, and will not be described in detail here.
The detection method of the invention can judge the internal condition of the tissue-imitating body model, thereby judging whether the tissue-imitating body model can support continuous use and continuous storage. The consistency and the accuracy of the tissue phantom imitation in the use process are ensured, and the method can be used for the tissue phantom imitation quality monitoring link.
Alternatively, the above-described detection method is performed once every predetermined time.
Given that the phantom is environmentally sensitive, each execution of the upper detection method is optionally performed at the same temperature in order to ensure consistency of each measurement.
The tissue phantom is strict in use and storage conditions. Firstly, the surface of the tissue-imitating phantom needs to be ensured to be clean and tidy; when in use, only water or a special ultrasonic couplant is supported to contact the surface of the tissue phantom, and after use, water or neutral soap is used for cleaning and wiping.
The surface of the tissue-imitating body model cannot contact a sharp object; the surface of the tissue phantom cannot be excessively pressed. After use, the tissue phantom is covered by a tissue phantom protective cover (if the protective cover is lost, the tissue phantom is sealed by a preservative film or a sealing bag); the surface was kept wet during storage.
The surface of the tissue phantom is strictly kept from contact with fat-soluble or corrosive solutions (such as alcohol, acidic or basic solutions); under the condition of non-use, the tissue-imitated phantom is stored according to the storage condition; the tissue phantom is stored in a sealed way by ensuring the humidity of the air or the surface of the tissue phantom (placing the sponge or the water-containing latex which is moist but can not extrude water between the surface of the tissue phantom and the protective cover of the tissue phantom).
Storage and use temperatures of the simulated tissue phantom: the temperature of room temperature (15-30 ℃, the imitation freezing point is 0 ℃, the imitation boiling point is 100 ℃, and the imitation is damaged in the freezing and unfreezing processes.
Although some specific embodiments of the present invention have been described in detail by way of examples, it should be understood by those skilled in the art that the above examples are for illustrative purposes only and are not intended to limit the scope of the present invention. It will be appreciated by those skilled in the art that modifications may be made to the above embodiments without departing from the scope and spirit of the invention. The scope of the invention is defined by the appended claims.
Claims (13)
1. A tissue phantom-simulated detection method is characterized by comprising the following steps:
weighing the tissue phantom, comparing the weighing result with the nominal weight of the tissue phantom, and carrying out ultrasonic detection on the tissue phantom if the measured result deviates from the nominal weight and is less than a preset value; if the tissue phantom is larger than the preset value, the tissue phantom does not meet the conditions of continuous storage and continuous use any more, and the tissue phantom is returned to the factory for maintenance or scrapped;
wherein the performing ultrasonic testing on the tissue phantom comprises:
obtaining ultrasound data of the simulated tissue phantom, and
judging whether the tissue-imitated body model is abnormal or not according to the ultrasonic data; wherein the content of the first and second substances,
the ultrasonic detection of the tissue phantom comprises a first ultrasonic measurement and a second ultrasonic measurement; constructing an ultrasonic image of the tissue phantom according to the ultrasonic data obtained by the first ultrasonic measurement, and judging whether the ultrasonic image is abnormal or not;
obtaining the sound velocity of the tissue-imitated body model according to the second ultrasonic measurement, and judging according to the change rate of the sound velocity; wherein, the abnormality comprises that scatterers are unevenly distributed, strong reflection regions, cracks and cavities exist, or the sound velocity change rate is larger than a threshold value, and if the abnormality is found, the tissue-imitated body model is turned over for maintenance or scrapped.
2. The detection method according to claim 1, wherein an ultrasound image of the tissue phantom is constructed from the ultrasound data, and a determination is made as to whether there is an abnormality in the ultrasound image.
3. The detection method according to claim 1, wherein the ultrasonic data is the sound velocity of the tissue phantom, and the determination is made according to the rate of change of the sound velocity from the nominal sound velocity of the tissue phantom.
4. The detection method according to claim 3, wherein the rate of change of the speed of sound n of the tissue phantom is calculated according to the formula:
d t for measuring the vertical distance from the upper surface to the lower surface of the tissue phantom, d 1 The vertical distance from the upper surface to the lower surface of the calibrated tissue-imitated body model is obtained;
and when the sound velocity change rate n of the tissue-imitated body model is greater than a preset value, returning the tissue-imitated body model to the factory for maintenance or scrapping.
5. The detection method according to claim 1, wherein in the weighing step, when the weight gain or loss of the mock tissue phantom is less than a first predetermined value, an ultrasound step is performed.
6. The method of claim 5, wherein the phantom is stored dehumidified when the weight of the phantom increases by less than a first predetermined value and greater than a second predetermined value.
7. The method of claim 5, wherein the mock tissue phantom is stored humidified when the weight loss of the mock tissue phantom is less than a first predetermined value and greater than a second predetermined value.
8. The detection method according to any one of claims 5 to 7, wherein the first predetermined value is 2%.
9. The detection method according to claim 6 or 7, wherein the second predetermined value is 1%.
10. The detection method according to claim 9, wherein the current air is humidified, or a moisture-keeping layer is attached to the surface of the tissue phantom.
11. The inspection method according to claim 1, further comprising a visual inspection step before the weighing step and the ultrasonic step.
12. The detection method according to claim 1, wherein the detection method is performed once every predetermined time.
13. The detection method according to claim 12, wherein each execution of the detection method is performed at the same temperature.
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