CN110522512A - Radio-frequency ablation procedure auxiliary system based on model - Google Patents
Radio-frequency ablation procedure auxiliary system based on model Download PDFInfo
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- CN110522512A CN110522512A CN201910832306.6A CN201910832306A CN110522512A CN 110522512 A CN110522512 A CN 110522512A CN 201910832306 A CN201910832306 A CN 201910832306A CN 110522512 A CN110522512 A CN 110522512A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
- A61B2034/101—Computer-aided simulation of surgical operations
- A61B2034/105—Modelling of the patient, e.g. for ligaments or bones
Abstract
The radio-frequency ablation procedure auxiliary system based on model that the present invention relates to a kind of.The general cardiac module of the proposed generation for founding intracardiac electric signal of the present invention and conduction is enumerated doubtful heart state, is modeled and carry out parameter identification in conjunction with the relevant knowledge in electric signal observation and cardiac electrophysiology field in radio-frequency ablation procedure center；Intracardiac electric signal is labeled using the model of doubtful heart state, provides the estimation of current cardiac possible state for doctor, to reach more quickly accurate diagnosis.
Description
Technical field
It can be used in radio-frequency ablation procedure being used to that doctor to be assisted to carry out patient heart condition's judgement the present invention relates to a kind of
Auxiliary system.
Background technique
With the quickening of China human mortality aging, cardiac arrhythmia, especially rapid heart rate are uneven (Tachycardia),
One of the important diseases of our people's health are endangered through becoming.Cardiac arrhythmia is generated and is conducted different by electric signal in heart
It often results in, cardiac pumping efficiency is caused to decline, cause myocardial ischemia, or even dead.The uneven most common mechanism of rapid heart rate is
Turn back (Reentry): being connected as reentrant cycle (Reentry Circuit) by the conducting channel that cardiac muscle forms, electric signal is being rolled over
It returns Rapid Circulation in ring to conduct, triggers cardiac muscle quickly improper contraction, lead to the reduction of cardiac pumping efficiency.
Radio-frequency ablation procedure is one of essential therapeutic arsenals of tachy-arrhythmia, by passing through conduit (Catheters)
Femoral venous puncture gos deep into endocardial and observes intracardiac electric signal (EGM), and doctor can analyze production of the electric signal in heart of patient
Raw and conduction mode, realizes the diagnosis of the state of an illness and positions to reentrant cycle.Doctor can discharge radio frequency by conduit later
(RF) signal melts the partial conductance access of reentrant cycle, cuts off reentrant cycle while killing corresponding heart tissue, extensive
The normal cardiac rhythm of multiple heart.
Radio-frequency ablation procedure shows in the treatment of Ventricular Tachycardia, atrial tachycardia and junctional tachycardia
Extraordinary validity is gone out.It is also obtained in the complicated tachycardia cases such as atrial fibrillation (Atrial Fibrillation)
More better than drug curative effect.But radio-frequency ablation procedure still suffers from some challenges for being difficult to overcome, and leads to cost mistake of performing the operation
Height, threshold is excessively high, popularity rate is low.The significant challenge that radio-frequency ablation procedure faces includes:
Challenge one: to the indirect and discontinuity of patient's observation
Since radio-frequency ablation procedure belongs to Minimally Invasive Surgery, doctor can not be directly observed conduit in the heart in the course of surgery
Specific location in dirty, can only be inferred indirectly by the conduit two-dimensional projection that two groups of X-rays generate conduit in the position of three-dimensional space,
And rule of thumb infer the positional relationship of conduit and each chamber of heart.Simultaneously in order to control the duration that patient receives X-ray irradiation,
X-ray projection can only be obtained intermittently, lead to catheter location information in time discontinuous.
Due to the limitation of the simultaneous conduit quantity of endocardial, doctor can only be to the limited position of endocardial simultaneously
It is observed.Cope with this unfavorable situation, current scheme is by the fixed diagnostic catheter in several positions as reference point,
A constantly mobile ablation catheter turn back the positioning and ablation of access.The observation of intracardiac electric signal is in time and space
On discontinuously produce very big diagnosis blind area, patient status is quickly and accurately diagnosed and causes very big difficulty.
Challenge two: it is currently observed with history corresponding with patient's real heart situation
Due to the indirect of radio-frequency ablation procedure observation, doctor needs in the course of surgery will current and history observation packet
The information contained is pieced together, and the mode for generating and conducting to the intracardiac electric signal of patient restores.The process pair of this " brain benefit "
The experience and space imagining ability of doctor proposes very high requirement, and significantly increase in surgical mental disappears
Consumption.
Challenge three: the diversity of patient status
Since doctor is extremely limited to the observation of heart of patient in radio-frequency ablation procedure, different hearts be can produce
Very much like observation causes current and history observation that can be explained by a variety of doubtful hearts.Doctor was performing the operation
It needs to account for all doubtful hearts in journey, and is carried out when wherein certain hearts are without the new observation of method interpretation
It excludes, is finally reached unique correctly diagnosis.In order to distinguish doubtful heart, doctor needs the heart by conduit to patient
Dirty application stimulating electrical signal sequence lures that heart generates into using the mode of active stimulation and observes different signals from history.Fast
Consider multiple hearts simultaneously in the radio-frequency ablation procedure of rhythm and distinguish them to significantly increase doctor and bear
Load, the selection of stimulating electrical signal sequence relies primarily on the experience of doctor in complicated case, makes while lacking efficiency to patient
At unnecessary burden.
Challenge four: there is dispute to the theoretical of complicated tachy-arrhythmia mechanism
In the relatively-stationary case of ring position of turning back, doctor can periodically change searching rule by observation electric signal
Rule, facilitates the positioning to reentrant cycle access.However it is continuous at atrium/this reentrant cycle center of room fibrillation (Fibrillation)
In mobile case, electric signal is observed periodically weaker, and Rule Summary is difficult, and may explain that the doubtful situation of Current observation increases
More, the historical information for needing to trace is also more remote.Therefore in medical field to the generation of fibrillation and maintenance mechanism there is also dispute,
Treatment method also lacks specific aim, and main principle is split to the region that reentrant cycle is also easy to produce/maintained in atrium, reduces mixed
The range that random electric signal can influence.
In conclusion radio-frequency ablation procedure needs to consider multiplicity and complicated heart of patient situation, doctor is needed to answer
Therefore miscellaneous reasoning and operation also leads to following problem:
1) time-consuming for operation
Usually at 2-6 hours or so, endurance and concentration to doctor propose non-the time-consuming of one radio-frequency ablation procedure
Often big challenge, also results in security risk to the health of patient.
2) high to the degree of dependence of doctors experience, it is big to popularize difficulty
Since the situation of patient is different, the Clinics and Practices of radio-frequency ablation procedure need particular problem to make a concrete analysis of.Operation
Success rate and efficiency be heavily dependent on the experience of doctor, this is greatly improved the threshold of radio-frequency ablation procedure,
Limit the universal of radio-frequency ablation procedure.
The demand of radio-frequency ablation procedure at home has the tendency that going up year by year, by 2010 54559 to 2017
133897, increased by 1393 relative to 2016.Using information technology developing intellectual resource ablation apparatus, complicated cardiac arrhythmia is explored
Mechanism, radio-frequency ablation procedure process is optimized, the threshold of radio-frequency ablation procedure can be reduced by providing auxiliary for doctor, drop
Low operation cost, promotes the safety of operation.
With the development of science and technology Medical Instruments manufacturer has developed various auxiliary systems for the challenge in radio-frequency ablation procedure
System is used to reduce burden of the doctor in ablative surgery.
For challenge one: to the indirect and discontinuity of patient condition observation
Medical Instruments manufacturer has developed the conduit that can observe more multiposition electrocardiosignal simultaneously, in specific heart area
Improve the spatial continuity of measurement.Thus the reduction of the mobile number of bring conduit also improves the time continuity of measurement.So
And thus also caused the surge of original data volume, system matched with this is only limitted to visualize for increasing the processing of data newly,
The diagnosis of doctor is helped limited.
For challenge two: currently being observed with history corresponding with patient's real heart situation
Medical Instruments manufacturer develops the conduit that can be tracked and matched conduit tracking system using electromagnetic location principle
System.Using conduit historical position information, which can realize following several functions: 1) doctor can be at operation initial stage to target cavity
Inner wall using conduit carry out position sampling, using conduit historical position information generate wall of the heart 3-D view, for it
Operation afterwards provides reference system；2) phase difference that same stage collects signal in cardiac cycle to different location carries out visual
Change, doctor can infer conduction mode of the electrocardiosignal in heart to a certain extent accordingly；3) by different in heart
The electrical signal intensity of position measurement is visualized, and doctor can substantially judge the position of scar tissue, the positioning to reentrant cycle
There is certain help.Such auxiliary system is corresponding with the real heart situation of patient by history observation to a certain extent, is
Doctor provides effective data visualization, reduces the burden of doctor, improves the efficiency of radio-frequency ablation procedure.
In medical field and academia, there is also some kernel model based diagnosis to attempt, and utilizes the data point reuse heart mould of patient
Shape parameter establishes the exclusive cardiac module of patient, and carries out diagnosis according to the emulation of model and position with reentrant cycle.But due to such mould
Type complexity is too high, and the data of patient can not identify all parameters of model, the limitation of " exclusive ", only to diagnosis
Certain directive function can be played.Simultaneously because calculation amount is excessive, this class model is only suitable for carrying out preoperative and postoperative Analysis, opponent
The real-time instruction of diagnosis and positioning during art is limited.
For challenge three: the diversity of patient status
Existing radio-frequency ablation procedure auxiliary system mainly provides the visualization of historical data, also to the analysis of historical data
In the more preliminary stage.The estimation of most time-consuming heart state and doubtful pathology track aspect still in radio-frequency ablation procedure
Experience and continuous trial and error by doctor, therefore this is also the main point of penetration of this project.
For challenge four: there is dispute to the theoretical of complicated tachy-arrhythmia mechanism
Academia and medical field have developed some model cardiac complexs based on cardiac electrophysiology knowledge, for the complicated heart
It restrains the not normal mechanism emulation such as fibrillation and explores.But also due to the reason of model complexity, model is difficult to realize the special of patient
Categoryization has no directive function with positioning for the diagnosis in given patient surgical procedure.
In conclusion diagnosis and lesion localization booster action of the existing technology for doctor during radio-frequency ablation procedure
It is limited, in order to promote the success rate and efficiency of ablative surgery, mitigates the burden of doctor, provide Cheap highly effective for broad masses of the people
Medical condition, it would be desirable to exploitation in the course of surgery for doctor provide diagnosing and treating auxiliary radio-frequency ablation procedure assist
System.
Summary of the invention
It is an object of the invention in radio-frequency ablation procedure, auxiliary doctor carries out the judgement and disease of patient heart condition
The positioning of stove mitigates the burden of doctor to improve the efficiency of doctor.
In order to achieve the above object, the technical solution of the present invention is to provide a kind of radio-frequency ablation procedure based on model is auxiliary
Auxiliary system, which is characterized in that disagreement issuable during surgical diagnosis is explained and distinguished using cardiac module, and
Cardiac module is updated and excluded using the new information that obtains in surgical procedure, for doctor provide it is possible diagnose with it is corresponding according to
According to.It includes with lower unit:
Initial cardiac model foundation unit, for establishing K cardiac module H1, H2 ..., HK, comprising the following steps:
K cardiac module H1, H2 ..., HK are established according to known patient information before surgery, corresponding patient K doubtful
Heart.Each cardiac module includes dotted state machine and line state machine, and dotted state machine is to Observable in heart and inconsiderable
The critical tissue of survey, the cases such as general organizations and reentrant cycle entrance linked groups are modeled including sinoatrial node etc., mainly
The generation and barrier of heart tissue electric signal are simulated, and the transmission of electric signal is special between critical tissue in line state machine simulation heart
Property, including transmission delay etc..By adjusting the topological structure and parameter of point and line state machine, doctor can be to different hearts
It distinguishes and corresponding pathology is explained；
Intracardiac electric signal acquiring unit, for obtaining intracardiac electric signal, comprising the following steps:
There is N number of conduit in operation in heart of patient, each conduit has a corresponding signal annotation list, in signal annotation list
List it is a variety of on current catheter it can be observed that stress all possible mark of signal, mark to the source of induction signal or
Property can help doctor to carry out pathological analysis.At a time, conduit n obtains intracardiac electric signal, and what conduit observed stress believe
Number conduit is transmitted to by the electric signal that excitation signal source generates, intracardiac electric signal is obtained after extraction process；
Cardiac module screening unit, it is every to obtain the cardiac module filtered out after primary intracardiac electric signal for doctor's reference,
The following steps are included:
Step 1 sets the doubtful heart quantity Q=K of epicycle, next round doubtful heart quantity Q '=0；By intracardiac
Electric signal acquiring unit obtains intracardiac electric signal, judges all possible feelings in the excitation signal source for generating current intracardiac electric signal
Condition is equipped with the possible situation of L kind, if l=1, and extracting the possible J kind of current catheter stress signal mark；
J is initialized as 1 by step 2；
K is initialized as 1 by step 3；
Step 4 judges in k-th of cardiac module Hk with the presence or absence of stress signal with first of excitation signal source to jth kind
Mark corresponding access, and if it exists, then by currently stress signal be labeled as jth kind signal mark, according to this assume be based on the heart
Dirty model Hk generates cardiac module Hkj when assuming that being labeled as jth kind signal mark, and in cardiac module Hkj
Parameter is the restrictive condition of independent variable, enters step 5, if it does not exist, then enters step 6；
In above-mentioned steps 4, it may be corresponded to there are many mark, every kind of hypothesis mark is assumed based on the same cardiac module Hk
One (for next round) cardiac module；
The restrictive condition that step 4 obtains is compared step 5 with the physiology scope of model parameter, if according to limitation item
The calculated model parameter of part violates physiology common sense, then the cardiac module Hkj obtained step 4 is excluded, and 6 is entered step, if mould
Shape parameter meets physiology common sense, then the cardiac module Hkj that step 4 obtains is included in the doubtful heart of next round, next round
Doubtful heart quantity Q '=Q '+1, enters step 6；
J is updated to j+1 by step 6, if updated j >=J, enters step 7, otherwise return step 4；
L is updated to l+1 by step 7, if updated l >=L, enters step 8, otherwise return step 4；
K is updated to k+1 by step 8, if updated k >=Q, enters step 9, otherwise return step 4；
Step 9, by the doubtful heart of all next rounds cardiac module and corresponding electrocardiosignal mark show
Doctor updates Q=Q ', and new intracardiac electric signal is obtained by intracardiac electric signal acquiring unit.
Preferably, in the step 1, all possible situations in excitation signal source include oneself generation, external signal, on
One stress signal source etc..
Preferably, cardiac module is updated to obtaining new cardiac module the following steps are included:
Pass between the intracardiac electric signal acquiring unit current intracardiac electric signal obtained and the intracardiac electric signal of history
The relevant restrictive condition of model parameter is extracted in system, obtains a set of model parameter after carrying out linear optimization to complete cardiac module
Update.
The general cardiac module of the proposed generation for founding intracardiac electric signal of the present invention and conduction, in conjunction in radio-frequency ablation procedure
The relevant knowledge in intracardiac electric signal observation and cardiac electrophysiology field, enumerates, models and joins to doubtful heart state
Number identification；Intracardiac electric signal is labeled using the model of doubtful heart state, provides current cardiac possible state for doctor
Estimation, to reach more quickly accurate diagnosis.
Detailed description of the invention
Fig. 1 is cardiac module schematic diagram；
Fig. 2 is the conduit arrangement schematic diagram in heart radio frequency ablation operation；
Fig. 3 is surface electrocardiogram (I, II, III) and intracardiac electric signal (HRA, HBE)；
Fig. 4 A to Fig. 4 C is the cardiac module figure applied in heart radio frequency ablation operation；
Fig. 5 is route map of the invention.
Specific embodiment
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate the present invention
Rather than it limits the scope of the invention.In addition, it should also be understood that, after reading the content taught by the present invention, those skilled in the art
Member can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims and limited
Range.
The present invention is based on the cardiac modules that can simulate heart of patient situation that inventor proposed in 2010.The heart mould
Type follows the understanding in cardiac electrophysiology clinical practice for heart, to transmission mode of the electric signal in heart and postpone into
Row modeling.Electrical signals activity mainly has three generation, barrier and conduction properties in heart, as shown, sending out in cardiac module
Bright people devises Points And lines two states machine, respectively corresponds the Points And lines section in Fig. 1.Wherein dotted state machine is to specific heart tissue
It generates and the property of barrier electric signal is modeled, and line state machine builds the transmission delay of electric signal between points
Mould.Heart states different in this way can be modeled by adjusting the quantity, connection type and parameter of Points And lines state machine, and
Generate corresponding electrocardiosignal.By changing model topology structure and parameter, the cardiac module that inventor proposes can be emulated not
Same heart.
As shown in Fig. 2, in heart radio frequency ablation operation, doctor by conduit HRA, HIS mobile in heart, CS,
ABL, RVA observe the generation and conduction of electric signal in heart, carry out diagnosis to heart and lesion positions.
As seen from Figure 3, in intracardiac electric signal, each electric signal represents catheter electrode, and nearby the electric of heart tissue lives
Dynamic, by the precedence and time delay to electric signal between different catheter electrodes, doctor's deducibility electric signal is in entire heart
In generation and conduction mode.
Common conduit is mainly HRA, His, CS, RVA in ablative surgery, the electric signal source that each conduit can receive with
Position is had nothing in common with each other, and each conduit has a signal source list, is listed in the list of signal source a variety of on current catheter
It can be observed that electric signal source, dotted state can be used for each electric signal source (hereinafter defined as " stress signal source ")
Machine establishes cardiac module, and the connection between source is represented using line state machine.There are some known but nothings under different heart states
The structure that method is directly observed can impact electric signal, and the present invention also indicates these structures with Points And lines state machine, such as
Hollow dots in Fig. 4 A to Fig. 4 C indicate.Since observation point is limited, Current observation may can be explained there are many heart, this
These ambiguities are modeled by using different cardiac modules, and some of situations are arranged using physiological knowledge
It removes.It is as follows by the key step of invention operation:
Step 1 models all doubtful hearts using preoperative diagnosis；
Step 2 receives an electric signal (such as His conduit) in certain conduit；
Step 3, initial source (hereinafter defined as " excitation signal source ") possible to signal are enumerated, and { oneself is produced
It is raw, external signal, a upper signal }；
Step 4, to may the conduit for receiving signal generate electric signal stress signal mark enumerated that (such as His is led
His_A, His_H and the His_V of pipe)；
In step 3 and step 4, if there is the reasonable dismissal that excitation signal source to emergency parachute marks, from current electricity
The relevant restrictive condition of model parameter is extracted in relationship between signal and history electric signal, obtain after linear optimization a set of
Model parameter generates a new model；
Step 5, excluded according to the network structure of cardiac module a part of excitation signal source with stress signal source；
If the new model parameter that step 6, update obtain, that is, the model parameter optimized exceeds physiology scope, row
Except the model；
Step 7 repeats step 2- step 6, and remaining model is showed doctor.
A specific implementation of above-mentioned steps 3,4,5 is specifically shown with an example:
Assuming that testing a normal person, a stimulating electrical signal, i.e. excitation signal are issued by HRA_A electrode
Source is HRA_A electrode.2 electric signals are continuously received in His conduit, available according to above-mentioned steps:
1) His conduit receives first signal
2) excitation signal source is external signal (known to HRA_A)
3) stress signal mark may be His_A, His_H or His_V
4) access from HRA_A to His_A is found in cardiac module, which exists, and establishes a new heart mould
First signal is simultaneously labeled as His_A by type；
5) simultaneously obtain HRA_A to His_A line state machine transmission delay parameter equal to HRA_A to His_A signal it
Between time difference；
6) access from HRA_A to His_H is found in cardiac module, which exists, is updated to original model,
It establishes a new cardiac module and first signal is labeled as His_H；
7) since the time difference of known HRA_A to His_A is less than the time difference (physiology common sense) of HRA_A to His_H, the mould
Type is excluded.
8) access from HRA_A to His_V is found in cardiac module, which exists, but there are His_H on the access
And without there is (physiology common sense) before His_H, thus be excluded that the situation.
To herein when first signal there was only a kind of situation of His_A, for second signal, can see that
1) excitation signal source be external signal or it is upper one stress signal source；
2) for example upper one stress signal source His_A, find His_A to His_H access, the access exist, but this
There are HRA_A not to occur on access, therefore the situation is excluded；
3) if excitation signal source is external signal (known to HRA_A)
4) this stress signal source may be His_A, His_H or His_V
5) due to a upper signal be His_A, and signal source be not oneself generate, so stress signal source be His_
The case where A, is excluded；
6) access from HRA_A to His_H is found in cardiac module, which exists, existing cardiac module is updated,
It establishes a new cardiac module and first signal is labeled as His_H；
7) access from HRA_A to His_V is found in cardiac module, which exists, but there are His_H on the access
And do not occur before His_H, thus be excluded that the situation
8) two parts are divided by AV dotted state machine on the access from HRA_A to His_H, can be extracted from existing information
The line state machine time delay of HRA_A to AV is equal to the time delay of HRA_A to His_H measurement plus the time delay of AV to His_H out；
Therefore second signal only has a kind of situation of His_H.
Using the present invention, doctor's available ever-increasing tree in the course of surgery, wherein certain is for the moment
It carves each leaf node and represents a kind of cardiac module that can explain current cardiac situation, with the progress of operation, more discriminations
Justice occurs, and causes " bifurcated " of tree, but simultaneously as information content incrementally increases, and sets the thinner of " being cut out ".Medicine is relevant to be known
Know a part to be integrated into cardiac module, a part is integrated into exclusionary rules and extracts in model parameter restrictive condition, can be with
The progress of knowledge gradually expand, provide auxiliary for the diagnosis of doctor, and give readable explanation to the suggestion provided.
In cardiac module, we establish dotted state machine model for the various sources of intracardiac electric signal, and examine in auxiliary
The source of each electric signal is distinguished during disconnected, the result finally distinguished can serve as the mark of intracardiac electric signal
It is placed on each electric signal, if the signal of HBE in Fig. 3 corresponds to the His conduit in previous example, A and H therein are also corresponding
His_A, His_H in previous example.Due to the presence of ambiguity, a certain moment, currently intracardiac electric signal could in the course of surgery
Can there are many mask method, but as the acquisition ambiguity of information gradually eliminates, the mark of intracardiac electric signal can help doctor by
Step understands the foundation of certain diagnosis, is the important component of operation auxiliary.
Claims (3)
1. a kind of radio-frequency ablation procedure auxiliary system based on model, which is characterized in that using cardiac module to surgical diagnosis mistake
Issuable disagreement is explained and is distinguished in journey, and heart mould is updated and excluded using the new information obtained in surgical procedure
Type provides possible diagnosis and corresponding foundation for doctor comprising with lower unit:
Initial cardiac model foundation unit, for establishing K cardiac module H1, H2 ..., HK, comprising the following steps:
K cardiac module H1, H2 ..., HK, corresponding patient K doubtful hearts are established according to known patient information before surgery
Situation, each cardiac module include dotted state machine and line state machine, and dotted state machine is to Observable in heart and unobservable
Critical tissue and case linked groups are modeled, for simulating the generation and barrier of heart tissue electric signal, and linear state
Machine simulates the transmission characteristic of electric signal between critical tissue in heart；By adjusting the topological structure and ginseng of point and line state machine
Number, doctor distinguish different hearts and explain to corresponding pathology；
Intracardiac electric signal acquiring unit, for obtaining intracardiac electric signal, comprising the following steps:
There is N number of conduit in operation in heart of patient, each conduit has corresponding signal annotation list, lists in signal annotation list
It is a variety of on current catheter it can be observed that stress all possible mark of signal, mark the source to induction signal or property
Matter helps doctor to carry out pathological analysis；At a time, conduit n obtains intracardiac electric signal, conduit observe stress signal by
The electric signal that excitation signal source generates is transmitted to conduit, and intracardiac electric signal is obtained after extraction process；
Cardiac module screening unit, it is every to obtain the cardiac module filtered out after primary intracardiac electric signal for doctor's reference, including
Following steps:
Step 1 obtains intracardiac electric signal by intracardiac electric signal acquiring unit, judges the excitation letter for generating current intracardiac electric signal
All possible situations in number source, be equipped with L kind may situation, if l=1, and extracting the possible J kind of current catheter stress signal
Mark；
J is initialized as 1 by step 2；
K is initialized as 1 by step 3；
Step 4, judge in k-th of cardiac module Hk with the presence or absence of with first of excitation signal source to jth kind stress signal mark
Corresponding access, and if it exists, then by currently stress signal be labeled as jth kind signal mark, according to this assume be based on heart mould
Type Hk generates cardiac module Hkj when assuming that being labeled as jth kind signal mark, and with cardiac module Hkj intrinsic parameter
For the restrictive condition of independent variable, 5 are entered step, if it does not exist, then enters step 6；
The restrictive condition that step 4 obtains is compared step 5 with the physiology scope of model parameter, if according to restrictive condition meter
The model parameter of calculating violates physiology common sense, then the cardiac module Hkj obtained step 4 is excluded, and enters step 6, if model is joined
Number meets physiology common sense, then the cardiac module Hkj that step 4 obtains is included in the doubtful heart of next round, next round is doubtful
Heart quantity Q '=Q '+1, enters step 6；
J is updated to j+1 by step 6, if updated j >=J, enters step 7, otherwise return step 4；
L is updated to l+1 by step 7, if updated l >=L, enters step 8, otherwise return step 4；
K is updated to k+1 by step 8, if updated k >=Q, enters step 9, otherwise return step 4；
Step 9, by the doubtful heart of all next rounds cardiac module and corresponding electrocardiosignal mark show doctor,
Q=Q ' is updated, new intracardiac electric signal is obtained by intracardiac electric signal acquiring unit.
2. a kind of accessory heart model generating method that can be used for radio-frequency ablation procedure as described in claim 1, feature exist
In, in the step 1, all possible situations in excitation signal source include oneself generation, external signal, it is upper one stress signal
Source.
3. a kind of accessory heart model generating method that can be used for radio-frequency ablation procedure as described in claim 1, feature exist
In, cardiac module is updated to obtaining new cardiac module the following steps are included:
From the relationship between the intracardiac electric signal acquiring unit current intracardiac electric signal obtained and the intracardiac electric signal of history
The relevant restrictive condition of model parameter is extracted, obtains a set of model parameter after carrying out linear optimization to complete cardiac module more
Newly.
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| US8038625B2 (en) * | 2005-09-15 | 2011-10-18 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for three-dimensional mapping of electrophysiology information |
| WO2007069168A2 (en) * | 2005-12-15 | 2007-06-21 | Koninklijke Philips Electronics, N.V. | System and method for visualizing heart morphologyduring electrophysiology mapping and treatment |
| US10433929B2 (en) * | 2007-03-09 | 2019-10-08 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for local deformable registration of a catheter navigation system to image data or a model |
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- 2019-09-04 CN CN201910832306.6A patent/CN110522512A/en active Pending
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- 2020-08-31 CN CN202010893585.XA patent/CN112451088B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2021120536A1 (en) * | 2019-12-19 | 2021-06-24 | 成都迈格因科技有限公司 | Individualized positioning mapping system for atrial fibrillation lesions |
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| CN112451088B (en) | 2021-11-19 |
| CN112451088A (en) | 2021-03-09 |
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