CN110501511B - Online reagent adjusting method, device and analysis and detection system - Google Patents
Online reagent adjusting method, device and analysis and detection system Download PDFInfo
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- CN110501511B CN110501511B CN201910743502.6A CN201910743502A CN110501511B CN 110501511 B CN110501511 B CN 110501511B CN 201910743502 A CN201910743502 A CN 201910743502A CN 110501511 B CN110501511 B CN 110501511B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1048—General features of the devices using the transfer device for another function
- G01N2035/1055—General features of the devices using the transfer device for another function for immobilising reagents, e.g. dried reagents
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
- Y02P90/02—Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]
Abstract
The invention provides an online reagent adjusting method, an online reagent adjusting device and an analysis and detection system, and relates to the field of biotechnology. The online reagent adjustment method comprises the following steps: the method comprises the steps that an online reagent adjustment application instruction is detected, a first control instruction is sent to a reagent storage device, a first feedback instruction is sent to an upper computer, the first control instruction is used for controlling the reagent storage device to enter a reagent adjustment preparation state, and the first feedback instruction is used for controlling the upper computer to display application processing prompt information; acquiring all existing task queues; determining that target tasks in all existing task queues are completed, sending a second control instruction to the reagent storage device, sending a second feedback instruction to the upper computer, wherein the second control instruction is used for controlling the reagent storage device to enter a reagent adjustment state, the second feedback instruction is used for controlling the upper computer to display prompt information of success application, and the target tasks are tasks which finally use the reagent storage device. By utilizing the technical scheme of the invention, the detection efficiency of the analysis detection system can be improved.
Description
Technical Field
The invention belongs to the field of biotechnology, and particularly relates to an online reagent adjusting method, an online reagent adjusting device and an analysis and detection system.
Background
In the biomedical detection process, a special analysis detection system is adopted to take the reagent, and the reagent is added into a sample to be detected for detection.
A reagent storage device of an analysis and detection system stores a reagent kit containing detection consumables such as a reagent, and a probe or other device is used to take the reagent and add the reagent (abbreviated as sample addition) to a sample. In the detection process, the detection consumables such as reagents are gradually consumed. Under the condition that the detection consumable is exhausted, sample loading can only be stopped, the analysis detection system waits for completing detection of the sample to be detected after sample loading, and the reagent storage device is in a stop state, so that actions such as adding the detection consumable, replacing the detection consumable, unloading the detection consumable and the like can be performed on the reagent storage device, and the detection efficiency is reduced.
Disclosure of Invention
The embodiment of the invention provides an online reagent adjusting method, an online reagent adjusting device and an analysis and detection system, which can improve the detection efficiency of the analysis and detection system.
In a first aspect, an embodiment of the present invention provides an online reagent adjustment method, including: the method comprises the steps that an online reagent adjustment application instruction is detected, a first control instruction is sent to a reagent storage device, a first feedback instruction is sent to an upper computer, the first control instruction is used for controlling the reagent storage device to enter a reagent adjustment preparation state, the first feedback instruction is used for controlling the upper computer to display application processing prompt information, and the application processing prompt information is used for representing that the reagent storage device enters the reagent adjustment preparation state; acquiring all existing task queues; determining that target tasks in all existing task queues are completed, sending a second control instruction to the reagent storage device, sending a second feedback instruction to the upper computer, wherein the second control instruction is used for controlling the reagent storage device to enter a reagent adjustment state, the second feedback instruction is used for controlling the upper computer to display application success prompt information, the application success prompt information is used for representing that the reagent storage device enters the reagent adjustment state, and the target tasks are tasks using the reagent storage device finally.
In a second aspect, an embodiment of the present invention provides an online reagent adjustment device, including: the signal receiving and transmitting module is used for sending a first control instruction to the reagent storage device and a first feedback instruction to the upper computer, wherein the first control instruction is used for controlling the reagent storage device to enter a reagent adjustment preparation state, the first feedback instruction is used for controlling the upper computer to display application processing prompt information, and the application processing prompt information is used for representing that the reagent storage device enters the reagent adjustment preparation state; the task arrangement module is used for acquiring all the existing task queues; the signal receiving and transmitting module is further used for determining that target tasks in all existing task queues are completed, sending a second control instruction to the reagent storage device, sending a second feedback instruction to the upper computer, wherein the second control instruction is used for controlling the reagent storage device to enter a reagent adjustment state, the second feedback instruction is used for controlling the upper computer to display application success prompt information, the application success prompt information is used for representing that the reagent storage device enters the reagent adjustment state, and the target tasks are tasks using the reagent storage device at last.
In a third aspect, an embodiment of the present invention provides an analysis detection system, including: the online reagent adjusting device in the technical scheme of the second aspect; the reagent storage device is used for receiving a first control instruction sent by the online reagent adjusting device, entering a reagent adjusting preparation state according to the first control instruction, and receiving a second control instruction sent by the online reagent adjusting device, and entering a reagent adjusting state according to the second control instruction; the upper computer is used for receiving a first feedback instruction sent by the online reagent adjusting device, displaying application processing prompt information according to the first feedback instruction, and receiving a second feedback instruction sent by the online reagent adjusting device, and displaying application success prompt information according to the second feedback instruction; the application processing prompt message is used for representing that the reagent storage device enters a reagent adjustment preparation state, and the application success prompt message is used for representing that the reagent storage device enters the reagent adjustment state.
The embodiment of the invention provides an online reagent adjusting method, an online reagent adjusting device and an analysis and detection system, which can control a reagent storage device to enter a reagent adjusting preparation state and control an upper computer to display application processing prompt information under the condition that an online reagent adjusting application instruction is detected. In the process, all the existing task queues are acquired, the target tasks in all the existing task queues are determined to be completed, the reagent storage device is controlled to enter a reagent adjustment state, and the upper computer is controlled to display prompt information of success application. So that the reagent storage device which is still not stopped on line can be subjected to operations such as reagent addition, reagent replacement or reagent unloading and the like when the tasks related to the reagent storage device are finished, and the processing of the tasks which are not finished in all the existing task queues by devices except the reagent storage device in the analysis detection system can be synchronously performed. And the operations of adding reagent, replacing reagent or unloading reagent and the like to the reagent storage device are not needed to wait for all the tasks in all the existing task queues to be processed and the reagent storage device is in a stop state. Therefore, the waiting time required for carrying out operations such as reagent adding, reagent replacing or reagent unloading on the reagent storage device is reduced, and the detection efficiency of the analysis detection system is improved.
Drawings
The invention will be better understood from the following description of specific embodiments thereof taken in conjunction with the accompanying drawings in which like or similar reference characters designate like or similar features.
FIG. 1 is a schematic diagram of a part of an analysis and detection system according to an embodiment of the present invention;
FIG. 2 is a flow chart of an online reagent adjusting method according to an embodiment of the invention;
FIG. 3 is a flow chart of an on-line reagent adjustment method according to another embodiment of the present invention;
FIG. 4 is a schematic diagram of an on-line reagent adjusting apparatus according to an embodiment of the present invention.
Detailed Description
Features and exemplary embodiments of various aspects of the invention are described in detail below. In the following detailed description, numerous specific details are set forth in order to provide a thorough understanding of the invention. It will be apparent, however, to one skilled in the art that the present invention may be practiced without some of these specific details. The following description of the embodiments is merely intended to provide a better understanding of the invention by showing examples of the invention. The present invention is in no way limited to any particular configuration and algorithm set forth below, but rather covers any modification, substitution, and improvement of elements, components, and algorithms without departing from the spirit of the invention. In the drawings and the following description, well-known structures and techniques have not been shown in order to avoid unnecessarily obscuring the present invention.
The embodiment of the invention provides an online reagent adjustment method, an online reagent adjustment device and an analysis detection system, which can be used in a scene of adding reagents, replacing the reagents or unloading the reagents to a reagent storage device. FIG. 1 is a schematic diagram of a part of an analysis and detection system according to an embodiment of the present invention. As shown in fig. 1, in some examples, the reagent storage device may be a reagent cartridge 11, the reagent cartridge 11 for storing reagents. Specifically, the reagent chamber 11 may have a circular basin structure with a top cover. The top cover can be provided with a bin gate which can be opened or closed. In some examples, the door can be opened or closed about a rotational axis provided to the top cover. A plurality of containers such as a reagent cartridge for containing a reagent can be placed in the reagent cartridge 11. The reagent bin 11 can rotate clockwise or anticlockwise around the center point of the reagent bin 11, and the reagent bin 11 can rotate to drive the containers such as the reagent kit to rotate. The analytical test system can also include a sample needle 12, the sample needle 12 being used to access reagents and to add reagents to the sample.
It should be noted that, the "reagent" in the embodiment of the present invention is a consumable used in the detection process, and may specifically be a liquid reagent, a solid reagent, a diluent, or the like, which is not limited herein.
As the reagent is dispensed, the reagent volume of the reagent gradually decreases until the consumption is completed. At present, if the consumption of the reagent is finished and a series of tasks existing in the analysis and detection system are not finished completely, each device in the analysis and detection system needs to wait for the completion of the series of tasks completely and can perform operations such as reagent addition, reagent replacement or reagent unloading on the reagent storage device when the reagent storage device is in a stop state. For example, if all task queues existing in the analysis and detection system include ten sample loading tasks and ten sample detection tasks. When the reagent is consumed, the sample loading task of five samples has been completed, but the detection task of these five samples is not completed, and the sample loading task and the detection task of the other five samples are not completed. After the detection tasks corresponding to the five samples which have completed the sample loading task are also completed, the reagent storage device is stopped, and the operations such as reagent addition, reagent replacement or reagent unloading can be performed on the reagent storage device. The waiting time of the reagent storage device for reagent adding, reagent replacing or reagent unloading and other operations is long, so that the detection efficiency of the analysis and detection system is affected.
There is a need for a reagent adjustment method that reduces the waiting time required for reagent adding, reagent changing, or reagent unloading operations to a reagent storage device, and improves the detection efficiency of an analytical detection system. FIG. 2 is a flow chart of an on-line reagent adjustment method according to an embodiment of the invention. The online reagent adjustment method may be performed by a module, unit, device, apparatus, or the like having a control function, such as a controller, a control module, or the like, and is not limited thereto. For convenience of explanation, the controller will be described below by taking an online reagent adjustment method as an example. As shown in fig. 2, the online reagent adjusting method may include steps S201 to S203.
In step S201, an online reagent adjustment application instruction is detected, a first control instruction is sent to the reagent storage device, and a first feedback instruction is sent to the host computer.
The online reagent adjustment application instruction is used for characterizing the request for online reagent adjustment. Reagent adjustment may include operations such as reagent addition, reagent replacement, or reagent unloading, and is not limited in this regard.
The first control instruction is for controlling the reagent storage device to enter a reagent adjustment ready state. That is, the reagent storage device receives the first control command and enters a reagent adjustment ready state. The reagent adjustment ready state is a ready state before entering the reagent adjustment state. In the reagent adjustment ready state, a task queue and a completion determination of tasks in the task queue may be made.
The first feedback instruction is used for controlling the upper computer to display application processing prompt information. The application processing prompt message is used for representing that the reagent storage device enters a reagent adjustment preparation state. The upper computer may be a special device, a computer, a tablet computer, a mobile phone, etc., which is not limited herein. The application processing prompt may be used to assist in prompting the operator to prepare for reagent adjustment. The specific content of the application processing prompt message is not limited herein. For example, a word or picture of "applying" may be displayed on the work interface of the host computer. For another example, an indicator light of the host computer indicating that the application is being filed may be lighted.
In step S202, all existing task queues are acquired.
The controller acquires all task queues existing in the analysis and detection system. In some examples, each sample may correspond to a task queue. A task queue includes at least one task. The tasks may include a liquid taking task, a sample adding task, a detection task, a cleaning task, and the like. The number of tasks in different task queues and the specific tasks may be different or the same. Multiple tasks of the same kind may be included in a task queue, for example, a task queue may include a sample application task, and may also include multiple sample application tasks, which are not limited herein.
In step S203, it is determined that the target task in all the existing task queues is completed, and a second control instruction is sent to the reagent storage device, and a second feedback instruction is sent to the host computer.
Wherein the target task is a task of last using the reagent storage device. Among all task queues, there may be multiple tasks using the reagent storage device. If the target task in all the existing task queues is completed, the subsequent tasks can not use the reagent storage device. The reagent storage device may enter a reagent adjustment state. In the reagent adjustment state, operations such as reagent addition, reagent replacement, and reagent unloading may be performed on the reagent storage device. The operations of adding, replacing, or unloading a specific reagent may be performed by manually operating the reagent storage device by an operator, or may be performed by operating an operating device provided for the reagent storage device, and the present invention is not limited thereto.
The second control instruction is used for controlling the reagent storage device to enter a reagent adjustment state. I.e. the reagent storage device is controlled to enter a reagent adjustment state by the second control instruction. And the reagent storage device receives the second control instruction and enters a reagent adjustment state.
The second feedback instruction is used for controlling the upper computer to display prompt information of success application. The application success prompt message is used for representing that the reagent storage device enters a reagent adjustment state. The application success prompt message can be used to assist in prompting the operator that reagent adjustment can be performed. The specific content of the application success prompt message is not limited herein. For example, a word or picture of "apply for success" may be displayed on the work interface of the host computer. For another example, an indicator light of the host computer indicating that the application was successful may be turned on.
In addition, when the reagent storage device enters the reagent adjustment state, other devices in the analysis and detection system can also process tasks. For example, the detection device may continue to process detection tasks. That is, the reagent storage device may be subjected to operations such as reagent addition, reagent replacement, and reagent unloading, in synchronization with the task processing of other devices in the analysis and detection system.
In the embodiment of the invention, the reagent storage device is controlled to enter a reagent adjustment preparation state and the upper computer is controlled to display application processing prompt information under the condition that an online reagent adjustment application instruction is detected. In the process, all the existing task queues are acquired, the target tasks in all the existing task queues are determined to be completed, the reagent storage device is controlled to enter a reagent adjustment state, and the upper computer is controlled to display prompt information of success application. So that the reagent storage device which is still not stopped on line can be subjected to operations such as reagent addition, reagent replacement or reagent unloading and the like when the tasks related to the reagent storage device are finished, and the processing of the tasks which are not finished in all the existing task queues by devices except the reagent storage device in the analysis detection system can be synchronously performed. And the operations of adding reagent, replacing reagent or unloading reagent and the like to the reagent storage device are not needed to wait for all the tasks in all the existing task queues to be processed and the reagent storage device is in a stop state. Therefore, the waiting time required for carrying out operations such as reagent adding, reagent replacing or reagent unloading on the reagent storage device is reduced, and the detection efficiency of the analysis detection system is improved.
Under the same conditions, the waiting time for reagent adjustment by adopting the prior art is far longer than that of the reagent adjustment by adopting the online reagent adjustment method in the embodiment of the invention. For example, under the same conditions, prior art techniques may require waiting 30 minutes or more before specific reagent adjustments can be made; while the online reagent adjustment method in the embodiment of the invention only needs to wait for 14 minutes or less before performing specific reagent adjustment.
FIG. 3 is a flow chart of an on-line reagent adjustment method according to another embodiment of the present invention. Fig. 3 is different from fig. 2 in that step S203 in fig. 2 may be specifically subdivided into steps S2031 to S2034 in fig. 3. In some examples, the generation of the online reagent adjustment application instruction may be triggered under some set conditions, and the online reagent adjustment method shown in fig. 3 may further include step S204 or step S205, correspondingly. In some examples, updating of reagent information may also be performed after reagent adjustment, and correspondingly, the online reagent adjustment method shown in fig. 3 may further include step S206 and step S207.
In step S204, if it is determined that the reagent amount of at least one reagent in the reagent storage device is lower than the reagent threshold value, an online reagent adjustment application command is generated.
In this example, the reagent threshold is an alert threshold where the reagent amount is low. If the amount of reagent in the reagent storage device is below the reagent threshold, indicating that the reagent is about to be consumed, operations such as reagent addition, reagent replacement, or reagent unloading are required to be performed on the reagent storage device, such as adding the reagent of the type in the reagent storage device, or unloading the reagent with the amount of reagent below the reagent threshold from the reagent storage device, and replacing a new reagent to the location of the unloaded reagent.
In step S205, when a reagent adjustment request command input by a user is received, an online reagent adjustment request command is generated.
In this example, the controller may receive a reagent adjustment request instruction entered by a user, and generate an online reagent adjustment application instruction on-line. For example, a reagent adjustment application button is displayed on the man-machine interaction interface, the user clicks the reagent adjustment application button, and the controller receives a reagent adjustment request instruction input by the user to perform related operations.
In step S2031, tasks in all existing task queues are acquired.
In the case where an online reagent adjustment application instruction is detected, the target task may not be completed yet. The controller needs to determine the time for triggering and controlling the reagent storage device to enter the reagent adjustment state according to the conditions of all the tasks in all the existing task queues.
In step S2032, control time information is determined based on the target task that was not started before and the target tasks in all the existing task queues.
If the task in the task queue is being processed or has been processed by a device in the analysis and detection system, the task is a started task. If the task in the task queue is not processed by the device in the analysis and detection system, the task is an unactuated task.
Specifically, according to the target task that is not started, the time that it takes to process the target task that is not started can be obtained. The time spent for processing the tasks not started before the target task can be obtained according to the tasks not started before the target task of all the existing task queues. The control time information may be determined based on the time it takes to process the target task that was not started, and the time it takes to process the task that was not started before the target task was processed. The time of sending the first control command to the reagent storage device is obtained according to the control time information. In some examples, the control time information may characterize a certain time, and the time indicated by the control time information is the time characterized by the control time information. In another example, the control time information may characterize a duration, and the time indicated by the control time information is a time after the current time passes the duration characterized by the control time information.
If the control time information characterizes the duration, the duration of the characterization is longer than or equal to the sum of the time spent for processing the target task which is not started and the time spent for processing the task which is not started before the target task. And if the time information characterizes the time, the time is characterized in that the current time passes through the target time length, and the target time length is longer than or equal to the sum of the time spent for processing the target task which is not started and the time spent for processing the task which is not started before the target task.
In some examples, a duration between the current time and the time indicated by the control time information may be taken as the waiting duration. The controller may send a third feedback instruction to the host computer. And the third feedback instruction is used for controlling the upper computer to display the waiting time. Thus, an operator can intuitively know when the reagent storage device can enter the reagent adjustment state. Specifically, the waiting time period can be displayed on a working interface of the upper computer, and the countdown is performed.
In step S2033, if the current time reaches the time indicated by the control time information, it is determined that the target task in all the existing task queues is completed.
The current time reaches the time indicated by the control time information, which indicates that the task of using the reagent storage device is completed, and the reagent storage device can be subjected to operations such as reagent addition, reagent replacement or reagent unloading, so that a second control instruction can be sent to the reagent storage device, and a second feedback instruction can be sent to the upper computer.
In step S2034, a second control command is sent to the reagent storage device, and a second feedback command is sent to the host computer.
In step S206, if it is detected that at least a part of the reagents in the reagent storage device have been adjusted, the reagent information of the reagents in the reagent storage device is obtained by rescanning.
Here, the adjustment of the reagent includes adding the reagent, replacing the reagent, unloading the reagent, and the like. When the reagent in the reagent storage device is adjusted, the reagent information of the reagent in the reagent storage device changes. To facilitate monitoring of the reagent in the reagent storage device, reagent information for the reagent in the reagent storage device may be rescanned. For example, the reagent storage device may scan the reagent cartridge at each location in the reagent storage device, with reagent information for reagents within the reagent cartridge recorded on the reagent cartridge.
In step S207, the reagent information database corresponding to the reagent storage device is updated based on the reagent information of the reagent in the reagent storage device acquired again.
The reagent information of the reagent in the reagent storage device obtained by scanning can be uploaded to a reagent information database to update the reagent information in the reagent information database. In some examples, the reagent information database is updated synchronously with the reagent information on the human-machine interface so that the operator can intuitively obtain the latest reagent information.
The reagent storage device may also exit the reagent adjustment state. In the embodiment of the invention, the reagent storage device can be controlled to exit the reagent adjustment state by sending a third control instruction to the reagent storage device. And the reagent storage device can be prompted to exit the reagent adjustment state by sending a fourth feedback instruction to the upper computer.
After the reagent storage device exits the reagent adjustment state, operations such as reagent addition, reagent replacement, and reagent unloading cannot be performed on the reagent storage device. The reagent storage device may be subjected to operations such as one-time reagent addition, reagent replacement, and reagent unloading, or may be subjected to repeated operations such as multiple reagent addition, reagent replacement, and reagent unloading, between the reagent storage device entering the reagent adjustment state and the reagent storage device exiting the reagent adjustment state, and the operations are not limited thereto.
In some examples, the third control instruction is sent to the reagent storage device and the fourth feedback instruction is sent to the upper computer if the reagent storage device is detected to enter a maintenance state or a reset state.
After the reagent storage device enters a maintenance state or a reset state, operations such as reagent addition, reagent replacement or reagent unloading and the like cannot be performed on the reagent storage device. Therefore, it is necessary to exit the reagent adjustment state before the reagent storage device enters the maintenance state or the reset state. For example, the controller receives a maintenance instruction or a reset instruction, sends a third control instruction to the reagent storage device, sends a fourth feedback instruction to the upper computer, and then performs maintenance operation or reset operation on the reagent storage device.
In other examples, if the process of starting the task by the reagent storage device is detected, a third control instruction is sent to the reagent storage device, and a fourth feedback instruction is sent to the upper computer.
The reagent storage device may initiate processing of the task after performing operations such as reagent addition, reagent replacement, or reagent unloading on the reagent storage device. In the process of processing tasks, operations such as reagent addition, reagent replacement or reagent unloading cannot be performed on the reagent storage device. Therefore, it is necessary to control the reagent storage device to exit the reagent adjustment state before the reagent storage device starts the processing of the task.
In still other examples, if an abnormality in the reagent storage device is detected, a third control instruction is sent to the reagent storage device, and a fourth feedback instruction is sent to the host computer.
The reagent storage device may be subject to an abnormality such as a malfunction or the like. In the case of abnormality of the reagent storage device, operations such as reagent addition, reagent replacement, and reagent unloading cannot be performed on the reagent storage device. Therefore, if an abnormality of the reagent storage device is detected, the reagent storage device is controlled to exit the reagent adjustment state.
If the reagent storage device is detected to exit the reagent adjustment state, processing of a new task may be initiated. In order that the reagent in the reagent storage device can directly participate in the sample adding task without influencing the detection result, if the reagent storage device is detected to exit the reagent adjustment state, a fourth control instruction is sent to the reagent storage device. And the fourth control instruction is used for controlling the reagent storage device to uniformly mix the reagent in the reagent storage device. The reagent through the mixing operation can directly participate in the sample adding task, for example, the reagent containing magnetic beads, and the fourth control instruction controls the reagent storage device to carry out the mixing operation on the reagent in the reagent storage device, so that the magnetic beads in the reagent are uniformly suspended, the reagent with the uniformly suspended magnetic beads is taken to participate in the sample adding task and the detection task, and even the added reagent or the replaced reagent can not influence the detection result.
In some examples, a fifth control instruction may also be sent to the sample processing device if it is determined that all of the existing target tasks in the task queue are completed. The sample processing device may process sample application tasks, detection tasks, and the like. The fifth control instruction is used for controlling the sample processing device to withdraw the sample which does not start the sample loading task to the placement area. Samples returned to the placement area do not participate in the task.
In particular, the placement area includes, but is not limited to, structures such as sample channels configured with the sample processing device.
FIG. 4 is a schematic diagram of an on-line reagent adjusting apparatus according to an embodiment of the present invention. As shown in fig. 4, the online reagent adjusting apparatus 300 includes a signal transceiver module 301 and a task collating module 302.
The signal transceiver module 301 is configured to send a first control instruction to the reagent storage device and send a first feedback instruction to the host computer.
The first control instruction is used for controlling the reagent storage device to enter a reagent adjustment preparation state. The first feedback instruction is used for controlling the upper computer to display application processing prompt information. The application processing prompt message is used for representing that the reagent storage device enters a reagent adjustment preparation state.
The task sort module 302 is configured to obtain all existing task queues.
The signal transceiver module 301 is further configured to determine that all the existing target tasks in the task queue are completed, send a second control instruction to the reagent storage device, and send a second feedback instruction to the host computer.
The second control instruction is used for controlling the reagent storage device to enter a reagent adjustment state. The second feedback instruction is used for controlling the upper computer to display prompt information of success application. The application success prompt message is used for representing that the reagent storage device enters a reagent adjustment state. The target task is the task of last using the reagent storage device.
In the embodiment of the invention, the reagent storage device is controlled to enter a reagent adjustment preparation state and the upper computer is controlled to display application processing prompt information under the condition that an online reagent adjustment application instruction is detected. In the process, all the existing task queues are acquired, the target tasks in all the existing task queues are determined to be completed, the reagent storage device is controlled to enter a reagent adjustment state, and the upper computer is controlled to display prompt information of success application. So that the reagent storage device which is still not stopped on line can be subjected to operations such as reagent addition, reagent replacement or reagent unloading and the like when the tasks related to the reagent storage device are finished, and the processing of the tasks which are not finished in all the existing task queues by devices except the reagent storage device in the analysis detection system can be synchronously performed. And the operations of adding reagent, replacing reagent or unloading reagent and the like to the reagent storage device are not needed to wait for all the tasks in all the existing task queues to be processed and the reagent storage device is in a stop state. Therefore, the waiting time required for carrying out operations such as reagent adding, reagent replacing or reagent unloading on the reagent storage device is reduced, and the detection efficiency of the analysis detection system is improved.
In some examples, the signal transceiver module 301 may be specifically configured to obtain tasks in all existing task queues; determining control time information according to the unactuated target task and the unactuated task before the target task in all the existing task queues; if the current time reaches the time indicated by the control time information, determining that all the target tasks in the existing task queues are completed.
Further, the signal transceiver module 301 may be further specifically configured to take a duration from the current time to a time indicated by the control time information as a waiting duration; and sending a third feedback instruction to the upper computer.
The third feedback instruction is used for controlling the upper computer to display the waiting time.
In some examples, the online reagent adjustment device 300 may further include a generation module.
The generation module may be configured to generate an online reagent adjustment application instruction if it is determined that the reagent amount of at least one reagent in the reagent storage device is below a reagent threshold.
Alternatively, the generating module may be configured to generate the online reagent adjustment application command if the signal transceiver module 301 receives the reagent adjustment request command input by the user.
In some examples, the above-described signal transceiver module 301 may be further configured to: if the reagent storage device is detected, the reagent storage device enters a maintenance state or a reset state, a third control instruction is sent to the reagent storage device, and a fourth feedback instruction is sent to the upper computer; or if the reagent storage device is detected to start the task processing, sending a third control instruction to the reagent storage device and sending a fourth feedback instruction to the upper computer; or if the abnormality of the reagent storage device is detected, sending a third control instruction to the reagent storage device and sending a fourth feedback instruction to the upper computer.
The third control instruction is used for controlling the reagent storage device to exit the reagent adjustment state. The fourth feedback instruction is used for prompting the reagent storage device to exit the reagent adjustment state.
In some examples, the online reagent adjustment device may further include a scanning module and a updating module.
The scanning module may be configured to rescan the reagent information for the reagent in the reagent storage device if at least a portion of the reagent in the reagent storage device is detected as having been adjusted.
The updating module can be used for updating the reagent information database corresponding to the reagent storage device according to the reagent information of the reagent in the reagent storage device.
In some examples, the signal transceiver module 301 may be further configured to send a fourth control instruction to the reagent storage device if it detects that the reagent storage device exits the reagent adjustment state.
The fourth control instruction is used for controlling the reagent storage device to uniformly mix the reagent in the reagent storage device.
In some examples, the signal transceiver module 301 may be further configured to determine that the target task in all the existing task queues is completed, and send a fifth control instruction to the sample processing device.
The fifth control instruction is used for controlling the sample processing device to withdraw the sample which does not start the sample adding task to the placement area.
The embodiment of the invention also provides an analysis and detection system which can comprise the online reagent adjusting device, the reagent storage device and the upper computer in the embodiment.
The reagent storage device is used for receiving a first control instruction sent by the online reagent adjusting device, entering a reagent adjusting preparation state according to the first control instruction, and receiving a second control instruction sent by the online reagent adjusting device, and entering a reagent adjusting state according to the second control instruction.
The upper computer is used for receiving the first feedback instruction sent by the online reagent adjusting device, displaying application processing prompt information according to the first feedback instruction, and receiving the second feedback instruction sent by the online reagent adjusting device, and displaying application success prompt information according to the second feedback instruction.
The relevant content of the online reagent adjusting device can be referred to the relevant description in the above embodiments, and will not be repeated here.
The application processing prompt in the above embodiment is used to characterize the reagent storage device entering the reagent adjustment ready state. The application success prompt message is used for representing that the reagent storage device enters a reagent adjustment state.
An embodiment of the present application further provides a storage medium having a computer program stored thereon, where the computer program when executed by a processor can implement the online reagent adjustment method in the above embodiment.
It should be understood that, in the present specification, each embodiment is described in an incremental manner, and the same or similar parts between the embodiments are all referred to each other, and each embodiment is mainly described in a different point from other embodiments. For device embodiments, analytical test system embodiments and storage medium embodiments, reference may be made to the description of method embodiments for relevant points. The invention is not limited to the specific steps and structures described above and shown in the drawings. Those skilled in the art will appreciate that various alterations, modifications, and additions may be made, or the order of steps may be altered, after appreciating the spirit of the present invention. Also, a detailed description of known method techniques is omitted here for the sake of brevity.
Those skilled in the art will appreciate that the above-described embodiments are exemplary and not limiting. The different technical features presented in the different embodiments may be combined to advantage. Other variations to the disclosed embodiments can be understood and effected by those skilled in the art in view of the drawings, the description, and the claims. In the claims, the term "comprising" does not exclude other means or steps; the indefinite article "a" does not exclude a plurality; the terms "first," "second," and the like, are used for designating a name and not for indicating any particular order. Any reference signs in the claims shall not be construed as limiting the scope. The functions of the various elements presented in the claims may be implemented by means of a single hardware or software module. The presence of certain features in different dependent claims does not imply that these features cannot be combined to advantage.
Claims (10)
1. An on-line reagent conditioning method, comprising:
an online reagent adjustment application instruction is detected, a first control instruction is sent to a reagent storage device, a first feedback instruction is sent to an upper computer, the first control instruction is used for controlling the reagent storage device to enter a reagent adjustment preparation state, the first feedback instruction is used for controlling the upper computer to display application processing prompt information, and the application processing prompt information is used for representing that the reagent storage device enters the reagent adjustment preparation state;
acquiring all existing task queues;
determining that target tasks in all existing task queues are completed, sending a second control instruction to a reagent storage device, sending a second feedback instruction to an upper computer, wherein the second control instruction is used for controlling the reagent storage device to enter a reagent adjustment state, the second feedback instruction is used for controlling the upper computer to display application success prompt information, the application success prompt information is used for representing that the reagent storage device enters the reagent adjustment state, and the target tasks are tasks which finally use the reagent storage device.
2. The method of claim 1, wherein said determining that the target task in the existing all-task queue is completed comprises:
acquiring tasks in all the existing task queues;
determining control time information according to the target task which is not started and the tasks which are not started before the target task in all the existing task queues;
and if the current time reaches the time indicated by the control time information, determining that the target tasks in all the existing task queues are completed.
3. The method according to claim 2, further comprising, after said determining control time information based on said target task that was not started and a task that was not started before said target task,:
taking the time length from the current time to the time indicated by the control time information as the waiting time length;
and sending a third feedback instruction to the upper computer, wherein the third feedback instruction is used for controlling the upper computer to display the waiting duration.
4. The method of claim 1, further comprising, prior to the detecting the online reagent adjustment application command and sending the first feedback command to the host computer:
if the reagent amount of at least one reagent in the reagent storage device is determined to be lower than a reagent threshold value, generating the online reagent adjustment application instruction;
or alternatively, the process may be performed,
and if a reagent adjustment request instruction input by a user is received, generating the online reagent adjustment application instruction.
5. The method of claim 1, further comprising, after the sending the second control command to the reagent storage device and the sending the second feedback command to the host computer:
if the reagent storage device is detected to be in a maintenance state or a reset state, a third control instruction is sent to the reagent storage device, and a fourth feedback instruction is sent to the upper computer;
or alternatively, the process may be performed,
if the reagent storage device is detected to start processing of a task, sending the third control instruction to the reagent storage device and sending the fourth feedback instruction to the upper computer;
or alternatively, the process may be performed,
if the abnormality of the reagent storage device is detected, sending the third control instruction to the reagent storage device and sending the fourth feedback instruction to the upper computer;
the third control instruction is used for controlling the reagent storage device to exit the reagent adjustment state, and the fourth feedback instruction is used for prompting the reagent storage device to exit the reagent adjustment state.
6. The method as recited in claim 1, further comprising:
rescanning to obtain reagent information for reagents in the reagent storage device if at least a portion of the reagents in the reagent storage device are detected to have been adjusted;
and updating a reagent information database corresponding to the reagent storage device according to the reagent information of the reagent in the reagent storage device acquired again.
7. The method as recited in claim 1, further comprising:
and if the reagent storage device is detected to exit the reagent adjustment state, sending a fourth control instruction to the reagent storage device, wherein the fourth control instruction is used for controlling the reagent storage device to uniformly mix the reagent in the reagent storage device.
8. The method as recited in claim 1, further comprising:
and determining that the target tasks in all the existing task queues are completed, and sending a fifth control instruction to the sample processing device, wherein the fifth control instruction is used for controlling the sample processing device to withdraw the samples which do not start the sample adding task to a placement area.
9. An on-line reagent adjustment device, comprising:
the signal receiving and transmitting module is used for sending a first control instruction to the reagent storage device and sending a first feedback instruction to the upper computer, wherein the first control instruction is used for controlling the reagent storage device to enter a reagent adjustment preparation state, the first feedback instruction is used for controlling the upper computer to display application processing prompt information, and the application processing prompt information is used for representing that the reagent storage device enters the reagent adjustment preparation state;
the task arrangement module is used for acquiring all the existing task queues;
the signal receiving and transmitting module is further used for determining that target tasks in all existing task queues are completed, sending a second control instruction to the reagent storage device and sending a second feedback instruction to the upper computer, wherein the second control instruction is used for controlling the reagent storage device to enter a reagent adjustment state, the second feedback instruction is used for controlling the upper computer to display application success prompt information, the application success prompt information is used for representing that the reagent storage device enters the reagent adjustment state, and the target tasks are tasks which finally use the reagent storage device.
10. An analytical test system comprising:
the online reagent adjusting apparatus of claim 9;
the reagent storage device is used for receiving a first control instruction sent by the online reagent adjusting device, entering a reagent adjusting preparation state according to the first control instruction, and receiving a second control instruction sent by the online reagent adjusting device, and entering a reagent adjusting state according to the second control instruction;
the upper computer is used for receiving a first feedback instruction sent by the online reagent adjusting device, displaying application processing prompt information according to the first feedback instruction, receiving a second feedback instruction sent by the online reagent adjusting device, and displaying application success prompt information according to the second feedback instruction;
the application processing prompt message is used for representing that the reagent storage device enters a reagent adjustment preparation state, and the application success prompt message is used for representing that the reagent storage device enters the reagent adjustment state.
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| CN112858712B (en) * | 2019-11-28 | 2024-04-05 | 深圳市帝迈生物技术有限公司 | Method for introducing reagent information, sample detection device, and storage medium |
| CN113030499A (en) * | 2019-12-25 | 2021-06-25 | 深圳迈瑞生物医疗电子股份有限公司 | Reagent processing apparatus, reagent processing method, and computer-readable storage medium |
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