CN1104887A - Process for producing maibaimicin gastric soluble tablet - Google Patents
Process for producing maibaimicin gastric soluble tablet Download PDFInfo
- Publication number
- CN1104887A CN1104887A CN 94110662 CN94110662A CN1104887A CN 1104887 A CN1104887 A CN 1104887A CN 94110662 CN94110662 CN 94110662 CN 94110662 A CN94110662 A CN 94110662A CN 1104887 A CN1104887 A CN 1104887A
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- China
- Prior art keywords
- meleumycin
- tablet
- gastric soluble
- starch
- soluble tablet
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention uses the Chinese made material to compose the new recipe using as a substitute for the imported gastrosoluble tablet of medemycin, and is composed of Maibaimeisu, low substituted hydroxy-propyl cellulose, tween-80, carbooxymethyl starch, magnesium stearate and starch. The adhesive is added through thoroughly mixing and the soft matrial is made up after mixing for 4-5 min., The tablets are made up by the existent tabletting and drying technologies. Said tablet can completedly disintegrate within 2 min., and features high stripping degree and high bio-utilizing rate.
Description
The present invention relates to the production Technology of Meleumyin Tablets by HPLC, relate in particular to the production Technology of meleumycin gastric soluble tablet.
Existing meleumycin enteric coatel tablets can not collapse Jie in two hours in stomach, begin in the intestinal to collapse when being situated between even entered after two hours, and dissolution is lower, so the drug effect utilization rate is low.Do not produce the meleumycin gastric soluble tablet as yet on the market now, when key just was to use for reference the Recipe of midecamycin gastric soluble tablet, because the problem on the prescription, the dissolution problem still failed to solve.
The objective of the invention is to, overcome the deficiencies in the prior art part,, provide a kind of dissolution that improves existing meleumycin gastric soluble tablet, improve the production Technology of the meleumycin gastric soluble tablet of drug effect utilization rate with new prescription.
The production Technology of meleumycin gastric soluble tablet of the present invention is formed new prescription with domestic raw material, includes meleumycin, low-substituted hydroxypropyl cellulose, tween 80, carboxymethyl starch, magnesium stearate and appropriate amount of starch and forms.Formula material of the present invention is crossed 40 mesh sieves, press meleumycin 58%～60.5%, low-substituted hydroxypropyl cellulose 0.5%～2%, tween 80 0.5%～3%, carboxymethyl starch 0.5%～2%, magnesium stearate 2%, other is a starch, behind the mix homogeneously, add 32 kilograms of 5% binding agents by per 330,000, mix and make soft material after 4～5 minutes, adopt the drying and the tablet forming technique of prior art to make tablet.Like this, the uniform particles degree that drying is come out is good, and the sheet difference is steady during tabletting, collapses Jie well.The tablet that presses collapses Jie within 2 minutes fully, and dissolution is higher, and bioavailability is higher.
The meleumycin gastric soluble tablet that adopts the production Technology of meleumycin gastric soluble tablet of the present invention to make, the dissolution height, most lot number dissolutions reached 98%～108% in 20 minutes.It is 105.5% that clinical sample is chosen the lot number dissolution, and the midecamycin gastric soluble tablet dissolution that Japan produces is 101.7%.The meleumycin gastric soluble tablet that adopts the production Technology of meleumycin gastric soluble tablet of the present invention to produce can collapse Jie at short notice, through clinical verification, and drug effect utilization rate height, good effect does not have notable difference with the curative effect of import midecamycin gastric soluble tablet.
Below in conjunction with embodiment, the production Technology of meleumycin gastric soluble tablet of the present invention is further described.
Get meleumycin 59.5%, low-substituted hydroxypropyl cellulose 0.5%～2%, tween 80 0.5%～3%, carboxymethyl starch 0.5%～2%, magnesium stearate 2%, other is a starch, and fineness was wanted 40 mesh sieves.Behind the uniform mixing 4～5 minutes, add 32 kilograms of 5% binding agents by per 330,000, remix was made soft material after 4～5 minutes.Drying and tablet forming technique are made tablet, and the tablet of making is packed into gastric solubleness film-coat or coated tablet.The meleumycin gastric soluble tablet that adopts the production Technology of meleumycin gastric soluble tablet of the present invention to manufacture, dissolution height, drug effect utilization rate height.
Claims (2)
1, a kind of production Technology of meleumycin gastric soluble tablet, form new prescription with home-made raw material, including meleumycin, low-substituted hydroxypropyl cellulose, tween 80, carboxymethyl starch, magnesium stearate and appropriate amount of starch forms, it is characterized in that described meleumycin is 58%～60.5%, tween 80 is 0.5%～3%, low-substituted hydroxypropyl cellulose is 0.5%～2%, carboxymethyl starch is 0.5%～2%, magnesium stearate is 2%, other is a starch.
2, the production Technology of meleumycin gastric soluble tablet according to claim 1 is characterized in that by the described prescription uniform mixing of claim 1 after 4～5 minutes, added 32 kilograms of 5% binding agents by per 330,000, mixed and made soft material after 4～5 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94110662 CN1104887A (en) | 1994-06-14 | 1994-06-14 | Process for producing maibaimicin gastric soluble tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94110662 CN1104887A (en) | 1994-06-14 | 1994-06-14 | Process for producing maibaimicin gastric soluble tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1104887A true CN1104887A (en) | 1995-07-12 |
Family
ID=5034607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 94110662 Pending CN1104887A (en) | 1994-06-14 | 1994-06-14 | Process for producing maibaimicin gastric soluble tablet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1104887A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104109702A (en) * | 2014-06-30 | 2014-10-22 | 北大医药重庆大新药业股份有限公司 | Fermentation culture medium for meleumycin |
-
1994
- 1994-06-14 CN CN 94110662 patent/CN1104887A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104109702A (en) * | 2014-06-30 | 2014-10-22 | 北大医药重庆大新药业股份有限公司 | Fermentation culture medium for meleumycin |
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Legal Events
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |