CN110483649A - A kind of preparation method of novel dextrin and its application in dialyzate - Google Patents
A kind of preparation method of novel dextrin and its application in dialyzate Download PDFInfo
- Publication number
- CN110483649A CN110483649A CN201910802547.6A CN201910802547A CN110483649A CN 110483649 A CN110483649 A CN 110483649A CN 201910802547 A CN201910802547 A CN 201910802547A CN 110483649 A CN110483649 A CN 110483649A
- Authority
- CN
- China
- Prior art keywords
- dextrin
- reaction solution
- preparation
- molecular weight
- starch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001353 Dextrin Polymers 0.000 title claims abstract description 57
- 239000004375 Dextrin Substances 0.000 title claims abstract description 57
- 235000019425 dextrin Nutrition 0.000 title claims abstract description 57
- 238000002360 preparation method Methods 0.000 title claims abstract description 30
- 238000006243 chemical reaction Methods 0.000 claims abstract description 45
- 229920002472 Starch Polymers 0.000 claims abstract description 22
- 239000000126 substance Substances 0.000 claims abstract description 22
- 239000007921 spray Substances 0.000 claims abstract description 20
- 239000008107 starch Substances 0.000 claims abstract description 19
- 235000019698 starch Nutrition 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000002253 acid Substances 0.000 claims abstract description 12
- 239000000843 powder Substances 0.000 claims abstract description 10
- 238000001914 filtration Methods 0.000 claims abstract description 9
- 239000000463 material Substances 0.000 claims abstract description 4
- 239000002904 solvent Substances 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 20
- 238000001035 drying Methods 0.000 claims description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 15
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 14
- 230000007062 hydrolysis Effects 0.000 claims description 10
- 238000006460 hydrolysis reaction Methods 0.000 claims description 10
- 239000000385 dialysis solution Substances 0.000 claims description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 6
- 235000002639 sodium chloride Nutrition 0.000 claims description 5
- 241000196324 Embryophyta Species 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims description 3
- 235000019890 Amylum Nutrition 0.000 claims description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- 229920002261 Corn starch Polymers 0.000 claims description 3
- 244000017020 Ipomoea batatas Species 0.000 claims description 3
- 235000002678 Ipomoea batatas Nutrition 0.000 claims description 3
- 241000219780 Pueraria Species 0.000 claims description 3
- 239000001110 calcium chloride Substances 0.000 claims description 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 3
- 235000011148 calcium chloride Nutrition 0.000 claims description 3
- 239000008120 corn starch Substances 0.000 claims description 3
- 229940099112 cornstarch Drugs 0.000 claims description 3
- 238000004090 dissolution Methods 0.000 claims description 3
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 3
- 235000011147 magnesium chloride Nutrition 0.000 claims description 3
- 229920001592 potato starch Polymers 0.000 claims description 3
- 239000001540 sodium lactate Substances 0.000 claims description 3
- 229940005581 sodium lactate Drugs 0.000 claims description 3
- 235000011088 sodium lactate Nutrition 0.000 claims description 3
- 239000008215 water for injection Substances 0.000 claims description 3
- 230000035484 reaction time Effects 0.000 claims description 2
- 238000000502 dialysis Methods 0.000 abstract description 3
- 238000009826 distribution Methods 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 description 10
- 239000000047 product Substances 0.000 description 9
- 238000003756 stirring Methods 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 239000000498 cooling water Substances 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 238000004321 preservation Methods 0.000 description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- 229920002177 Icodextrin Polymers 0.000 description 4
- 230000000740 bleeding effect Effects 0.000 description 4
- 229940016836 icodextrin Drugs 0.000 description 4
- 230000003204 osmotic effect Effects 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229960000583 acetic acid Drugs 0.000 description 3
- 239000012362 glacial acetic acid Substances 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 238000009738 saturating Methods 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000009229 glucose formation Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
- C08B30/12—Degraded, destructured or non-chemically modified starch, e.g. mechanically, enzymatically or by irradiation; Bleaching of starch
- C08B30/18—Dextrin, e.g. yellow canari, white dextrin, amylodextrin or maltodextrin; Methods of depolymerisation, e.g. by irradiation or mechanically
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to peritoneal dialysis technical fields, and in particular to a kind of preparation method of novel dextrin and its application in dialyzate.The preparation method of the novel dextrin includes the following steps: that (1) is made from starch, and takes water as a solvent preparation farinaceous size, acid is added, reaction is hydrolyzed, and then plus water terminates reaction, obtains reaction solution 1；(2) reaction solution 1 is removed into substance of the reaction solution middle-molecular-weihydroxyethyl less than 3000 by film packet filtering, obtains reaction solution 2；(3) reaction solution 2 is removed into the substance that reaction solution middle-molecular-weihydroxyethyl is greater than 5000 by film packet filtering, obtains reaction solution 3, the molecular weight of material in the reaction solution 3 is 3000-5000；(4) reaction solution 3 is spray-dried by spray dryer, obtains dextrin powder.The distribution of the molecular weight of the obtained dextrin of the present invention is narrower, and range is more concentrated, and molecular weight is small, and product quality is than more uniform, so that osmolarity ranges are narrow, dosage is easy control.
Description
Technical field
The invention belongs to peritoneal dialysis technical fields, and in particular to the preparation method of a kind of novel dextrin and its in dialyzate
In application.
Background technique
The peritoneal dialysis solution of China's listing is imitated foreign countries using glucose as the dialyzate of bleeding agent, and glucose is as infiltration
Saturating agent toxic side effect is light, raw material is easy to get, economic convenient advantage.But there is also such deficiencies, that is, glucose meeting
It is rapidly absorbed into blood by peritonaeum, to lose osmosis without concentration difference.So using glucose as bleeding agent
Dialyzate one day with 4 bags.
The above problem is just not present in the peritoneal dialysis solution for using Icodextrin as bleeding agent, will not lose osmotic pressure, and one day
Only with one bag, China is there are no such product at present, and all among research, original grinds hundred spies for the producer of related peritoneal dialysis solution
Carrying out import registration.
But found in imitated research, everybody is a molecular weight model carrying out imitated this Icodextrin at present
Very wide mixture is enclosed, its weight average molecular weight range recorded on FDA orange paper is such a model from 13000 to 19000
It encloses, but surveying the smallest molecular weight is 600, maximum molecular weight to 200,000, such range is too wide, different size molecule
The dextrin of amount can all exist, and under certain mass unit, molecular number is also a biggish range, so that osmotic pressure be caused to have
Biggish range causes dosage to be difficult to accurately hold in the treatment, the also bad assurance product quality in production.Therefore,
The preparation method for studying a kind of dextrin that molecular number range is relatively narrow is particularly important.
Summary of the invention
The purpose of the present invention is to provide a kind of preparation method of novel dextrin and its applications in dialyzate, solve existing
Have dextrin molecular number range it is larger caused by the big problem of osmolarity ranges.
Realization process of the invention is as follows:
A kind of preparation method of novel dextrin, includes the following steps:
(1) it is made from starch, takes water as a solvent preparation farinaceous size, acid is added, reaction is hydrolyzed, then plus water is whole
It only reacts, obtains reaction solution 1；
(2) reaction solution 1 for obtaining step (1) removes object of the reaction solution middle-molecular-weihydroxyethyl less than 3000 by film packet filtering
Matter obtains reaction solution 2；
(3) reaction solution 2 for obtaining step (2) removes the object that reaction solution middle-molecular-weihydroxyethyl is greater than 5000 by film packet filtering
Matter obtains reaction solution 3, and the molecular weight of material in the reaction solution 3 is 3000-5000；
(4) reaction solution 3 that step (3) obtains is spray-dried by spray dryer, obtains dextrin powder.
Further, the mass percentage concentration of step (1) described farinaceous size is 40-70%；Entire body after step (1) acid adding
Sour mass percentage concentration is 2-6% in system；The temperature of hydrolysis is 60-80 DEG C, reaction time 5-10 hour.
Further, step (1) starch is plant amylum.
Further, step (1) plant amylum is selected from cornstarch, potato starch, starch from sweet potato, wheaten starch, open country
Raw acorn starch, pueraria starch.
Further, step (1) acid is hydrochloric acid, glacial acetic acid or sulfuric acid.
Further, step (2) and step (3) the film packet are purchase gained, and step (2) the film packet is Suez
3000 film packet of GK1812, step (3) the film packet are 5000 film packet of PT1812, and step (4) spray dryer is purchase
Gained.
Further, step (4) drying temperature is 120-170 DEG C, described drying time 2-10 hours, described spraying dry
The wriggling pump speed of dry machine is 1000mL/h.
The dextrin prepared using the preparation method of above-mentioned novel dextrin, the weight average molecular weight of prepared dextrin is 9000-
10000, number-average molecular weight is 3000-5000.
Application of the above-mentioned dextrin in peritoneal dialysis solution.
Application of the above-mentioned dextrin in peritoneal dialysis solution, concrete application method is: present invention side being added into water for injection
The dextrin and sodium chloride, sodium lactate, calcium chloride, magnesium chloride of method preparation, then dissolution, constant volume, adjusting pH value are to get saturating to peritonaeum
Analyse liquid.
The positive effect of the present invention:
(1) distribution of the molecular weight of the obtained dextrin of the present invention is narrower, and range is more concentrated, and molecular weight is small, product
Mass ratio is more uniform, so that osmolarity ranges are narrow, dosage is easy control.
(2) it is added without sodium hydroxide in the method for the present invention, so sodium impurity is not introduced in finished product dextrin, it will not be to rear
Continuous peritoneal dialysis liquid is impacted with feeding intake for sodium chloride in liquid.
(3) the dextrin substitution glucose prepared using the method for the present invention is prepared into dialyzate, and only needing 1 bag daily can satisfy
It needs, and the dialyzate of traditional glucose production is needed daily with 4 bags.
(4) the method for the present invention is simple, yield is big, and market application prospect is wide.
Specific embodiment
Below with reference to embodiment, the present invention will be further described.
In order to solve the problems, such as that osmolarity ranges caused by existing dextrin molecular number range is larger are big, the present invention provides one kind
The dextrin of the preparation method of novel dextrin and its application in dialyzate, specifically the method for the present invention preparation exists as bleeding agent
Application in dialyzate.Acid described in the method for the present invention is hydrochloric acid, glacial acetic acid or sulfuric acid, wherein the hydrochloric acid can be dense salt
Acid is also possible to the dilute hydrochloric acid of mass percentage concentration >=10%, and the sulfuric acid can be the concentrated sulfuric acid, and it is dense to be also possible to quality percentage
The dilute sulfuric acid of degree >=10%.Film packet used in the present invention is the GK1812 model and PT1812 model of SUEZ company, can also be with
Identical products substitution is acted on by other.The refined journey YC-019 of the model of used spray dryer, can also be by other function
It can identical spray dryer substitution.
The mentality of designing of the method for the present invention: starch is configured to farinaceous size, then different molecular is hydrolyzed into acid adding
The dextrin of amount falls dextrin of the molecular weight less than 3000 and small molecular weight impurity (such as acid by 3000 film packet filtering of Suez GK1812
Deng), the dextrin of molecular weight greater than 5000 or unhydrolysed starch etc., above-mentioned step are then fallen by 5000 film packet filtering of PT1812
Suddenly it realizes and the wider dextrin of molecular weight is screened, obtain the narrow dextrin of molecular weight, the Weight-average molecular of obtained dextrin
Amount is 9000-10000, and number-average molecular weight is 3000-5000, and because the distribution of its molecular weight is narrower, range is more concentrated, molecule
Measure small, product quality is than more uniform, so that osmolarity ranges are narrow, dosage is easy control.In addition, the method for the present invention can
With the dextrin or other decomposition products for screening any molecular weight ranges.
In the method for the present invention, after hydrolysis plus water terminates reaction, and the water being added here is two effects in fact: one
It is termination hydrolysis, second is that dilute reaction solution, so that the filtering of step (2) and step (3) is easier to carry out.The method of the present invention
The introducing that sodium ion in dextrin method can be prepared to avoid tradition, can also remove from traditional preparation process, and product washing etc. is numerous
Trivial process, and resulting product purity is higher.
Embodiment 1
Water 10000ml is added into reaction kettle, opens stirring, cornstarch 10000g is then added, after mixing evenly, system
The farinaceous size for being 50% at mass percentage concentration, 10% dilute hydrochloric acid, which is added, makes mass percentage concentration sour in whole system
3%, at 65 DEG C, hydrolysis is carried out 6 hours for heat preservation, and the cooling water of 5 times of amounts is added, so that reaction solution is cooled to room temperature, first uses
The film of Suez GK1812 3000 filters, and removes substance of the molecular weight less than 3000, leaves and takes the big part of molecular weight, then use
The film of PT1812 5000 filters, and removes the substance that molecular weight is greater than 5000, leaves and takes part of the molecular weight less than 5000, collection liquid
The molecular weight of middle substance is that 3000-5000 is spray-dried, drying temperature 150 then with refined journey YC-019 spray dryer
DEG C, drying time 8 hours, the wriggling pump speed of the spray dryer was 1000mL/h, obtained white dried dextrin powder
1510g, yield 15.1%.
Embodiment 2
Water 10000ml is added into reaction kettle, opens stirring, potato starch 6666.7g is then added, after mixing evenly,
The farinaceous size that mass percentage concentration is 40% is made, 37% concentrated hydrochloric acid, which is added, makes mass percentage concentration sour in whole system
It is 5%, at 70 DEG C, hydrolysis is carried out 5 hours for heat preservation, and the cooling water of 8 times of amounts is added, so that reaction solution is cooled to room temperature, first uses
The film of Suez GK1812 3000 filters, and removes substance of the molecular weight less than 3000, leaves and takes the big part of molecular weight, then use
The film of PT1812 5000 filters, and removes the substance that molecular weight is greater than 5000, leaves and takes part of the molecular weight less than 5000, collection liquid
The molecular weight of middle substance is that 3000-5000 is spray-dried, drying temperature 120 then with refined journey YC-019 spray dryer
DEG C, drying time 10 hours, the wriggling pump speed of the spray dryer was 1000mL/h, obtained white dried dextrin powder
1890g, yield 28%.
Embodiment 3
Water 10000ml is added into reaction kettle, opens stirring, starch from sweet potato 15000g is then added, after mixing evenly, system
The farinaceous size for being 60% at mass percentage concentration, 98% concentrated sulfuric acid, which is added, makes mass percentage concentration sour in whole system
6%, at 60 DEG C, hydrolysis is carried out 10 hours for heat preservation, and the cooling water of 10 times of amounts is added, so that reaction solution is cooled to room temperature, first uses
The film of Suez GK1812 3000 filters, and removes substance of the molecular weight less than 3000, leaves and takes the big part of molecular weight, then use
The film of PT1812 5000 filters, and removes the substance that molecular weight is greater than 5000, leaves and takes part of the molecular weight less than 5000, collection liquid
The molecular weight of middle substance is that 3000-5000 is spray-dried, drying temperature 170 then with refined journey YC-019 spray dryer
DEG C, drying time 2 hours, the wriggling pump speed of the spray dryer was 1000mL/h, obtained white dried dextrin powder
2160g, yield 14.4%.
Embodiment 4
Water 10000ml is added into reaction kettle, opens stirring, wheaten starch 23333.3g is then added, after mixing evenly,
The farinaceous size that mass percentage concentration is 70% is made, 10% dilute sulfuric acid, which is added, makes mass percentage concentration sour in whole system
It is 2%, at 80 DEG C, hydrolysis is carried out 8 hours for heat preservation, and the cooling water of 8 times of amounts is added, so that reaction solution is cooled to room temperature, first uses
The film of Suez GK1812 3000 filters, and removes substance of the molecular weight less than 3000, leaves and takes the big part of molecular weight, then use
The film of PT1812 5000 filters, and removes the substance that molecular weight is greater than 5000, leaves and takes part of the molecular weight less than 5000, collection liquid
The molecular weight of middle substance is that 3000-5000 is spray-dried, drying temperature 160 then with refined journey YC-019 spray dryer
DEG C, drying time 5 hours, the wriggling pump speed of the spray dryer was 1000mL/h, obtained white dried dextrin powder
3540g, yield 15.2%.
Embodiment 5
Water 10000ml is added into reaction kettle, opens stirring, wild acorn starch 10000g is then added, stirs evenly
Afterwards, the farinaceous size that mass percentage concentration is 50% is made, glacial acetic acid, which is added, makes mass percentage concentration sour in whole system
2%, at 60 DEG C, hydrolysis is carried out 7 hours for heat preservation, and the cooling water of 10 times of amounts is added, so that reaction solution is cooled to room temperature, first uses
The film of Suez GK1812 3000 filters, and removes substance of the molecular weight less than 3000, leaves and takes the big part of molecular weight, then use
The film of PT1812 5000 filters, and removes the substance that molecular weight is greater than 5000, leaves and takes part of the molecular weight less than 5000, collection liquid
The molecular weight of middle substance is that 3000-5000 is spray-dried, drying temperature 150 then with refined journey YC-019 spray dryer
DEG C, drying time 8 hours, the wriggling pump speed of the spray dryer was 1000mL/h, obtained white dried dextrin powder
1660g, yield 16.6%.
Embodiment 6
Water 10000ml is added into reaction kettle, opens stirring, pueraria starch 10000g is then added, after mixing evenly, system
The farinaceous size for being 50% at mass percentage concentration, 10% dilute hydrochloric acid, which is added, makes mass percentage concentration sour in whole system
4%, at 75 DEG C, hydrolysis is carried out 7 hours for heat preservation, and the cooling water of 6 times of amounts is added, so that reaction solution is cooled to room temperature, first uses
The film of Suez GK1812 3000 filters, and removes substance of the molecular weight less than 3000, leaves and takes the big part of molecular weight, then use
The film of PT1812 5000 filters, and removes the substance that molecular weight is greater than 5000, leaves and takes part of the molecular weight less than 5000, collection liquid
The molecular weight of middle substance is that 3000-5000 is spray-dried, drying temperature 150 then with refined journey YC-019 spray dryer
DEG C, drying time 8 hours, the wriggling pump speed of the spray dryer was 1000mL/h, obtained white dried dextrin powder
1380g, yield 13.8%.
7 dialyzate of embodiment is prepared
Table 1 prepares the formula of dialyzate 1-6 using dextrin prepared by embodiment 1-6
The above-mentioned specific process for preparation of dialyzate is to take 800 milliliters of water for injection, and the every group of formula of above-mentioned material is added in order
After entering dextrin, sodium chloride, sodium lactate, calcium chloride and magnesium chloride dissolution mixing, 10000 milliliters are settled to, appropriate hydrochloric acid tune pH is added
It is filling in medicinal fluid bag by 2000 milliliters of single dose for 5.5-6.0, it is sterilized using overkill method to obtain the final product.
Studied by long term test, using the method for the present invention prepare dextrin prepare dialyzate osmotic pressure be 380 ±
20mmol/kg.And existing Icodextrin peritoneal dialysis solution reference preparation osmotic pressure after measured, the result is that 324 ± 96mmol/
kg.The dialyzate osmolarity ranges that obvious Icodextrin is prepared are wider.The dextrin of the method for the present invention preparation can be also used for other
In dialyzate or infiltration formula of liquid, the present invention is no longer described in detail.
The above content is specific preferred embodiment further description to made by the present invention is combined, cannot recognize
Fixed specific implementation of the invention is only limitted to these explanations.For those skilled in the art, do not taking off
Under the premise of from present inventive concept, several simple deduction or replace can also be made, all should be considered as and belong to protection of the invention
Range.
Claims (10)
1. a kind of preparation method of novel dextrin, which comprises the steps of:
(1) it is made from starch, takes water as a solvent preparation farinaceous size, acid is added, reaction is hydrolyzed, then plus water terminates instead
It answers, obtains reaction solution 1；
(2) reaction solution 1 for obtaining step (1) removes substance of the reaction solution middle-molecular-weihydroxyethyl less than 3000 by film packet filtering, obtains
To reaction solution 2；
(3) reaction solution 2 for obtaining step (2) removes the substance that reaction solution middle-molecular-weihydroxyethyl is greater than 5000 by film packet filtering, obtains
To reaction solution 3, the molecular weight of material in the reaction solution 3 is 3000-5000；
(4) reaction solution 3 that step (3) obtains is spray-dried by spray dryer, obtains dextrin powder.
2. the preparation method of novel dextrin according to claim 1, it is characterised in that: the matter of step (1) described farinaceous size
Amount percentage concentration is 40-70%；Mass percentage concentration sour in whole system is 2-6% after step (1) acid adding；Hydrolysis
Temperature is 60-80 DEG C, reaction time 5-10 hour.
3. the preparation method of novel dextrin according to claim 1, it is characterised in that: step (1) starch is plant shallow lake
Powder.
4. the preparation method of novel dextrin according to claim 3, it is characterised in that: step (1) described plant amylum is selected from
Cornstarch, potato starch, starch from sweet potato, wheaten starch, wild acorn starch, pueraria starch.
5. the preparation method of novel dextrin according to claim 1, it is characterised in that: step (1) acid is hydrochloric acid, ice second
Acid or sulfuric acid.
6. the preparation method of novel dextrin according to claim 1, it is characterised in that: step (2) and step (3) the film packet
For purchase gained, step (2) the film packet is Suez GK18123000 film packet, and step (3) the film packet is PT18125000 film
Packet, step (4) spray dryer are purchase gained.
7. the preparation method of novel dextrin according to claim 1, it is characterised in that: step (4) described drying temperature is
120-170 DEG C, described drying time 2-10 hours, the wriggling pump speed of the spray dryer was 1000mL/h.
8. using claim 1 to 7 it is one of any described in novel dextrin preparation method preparation dextrin, it is characterised in that: institute
The weight average molecular weight of the dextrin of preparation is 9000-10000, and number-average molecular weight is 3000-5000.
9. application of the dextrin described in claim 8 in peritoneal dialysis solution.
10. application of the dextrin in peritoneal dialysis solution according to claim 9, it is characterised in that: be added into water for injection
The method of the present invention preparation dextrin and sodium chloride, sodium lactate, calcium chloride, magnesium chloride, then dissolution, constant volume, adjusting pH value to get
To peritoneal dialysis solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910802547.6A CN110483649A (en) | 2019-08-28 | 2019-08-28 | A kind of preparation method of novel dextrin and its application in dialyzate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910802547.6A CN110483649A (en) | 2019-08-28 | 2019-08-28 | A kind of preparation method of novel dextrin and its application in dialyzate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110483649A true CN110483649A (en) | 2019-11-22 |
Family
ID=68554749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910802547.6A Pending CN110483649A (en) | 2019-08-28 | 2019-08-28 | A kind of preparation method of novel dextrin and its application in dialyzate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110483649A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4445938A (en) * | 1979-01-08 | 1984-05-01 | Roquette Freres | Hydrogenated starch hydrolysate |
| CN103467608A (en) * | 2013-09-27 | 2013-12-25 | 华仁药业股份有限公司 | Icodextrin and preparing method thereof |
| CN105131135A (en) * | 2015-09-17 | 2015-12-09 | 成都博佳制药有限公司 | Industrial production method of icodextrin |
| CN106397616A (en) * | 2016-08-30 | 2017-02-15 | 华南理工大学 | Preparation method of icodextrin for starch-based peritoneal dialysis solution |
| WO2018146345A1 (en) * | 2017-03-31 | 2018-08-16 | Opterion Health Ag | Carbohydrate composition for dialysis |
| CN110025631A (en) * | 2019-04-19 | 2019-07-19 | 西安乐析医疗科技有限公司 | A kind of novel peritoneal dialysis solution and preparation method thereof |
-
2019
- 2019-08-28 CN CN201910802547.6A patent/CN110483649A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4445938A (en) * | 1979-01-08 | 1984-05-01 | Roquette Freres | Hydrogenated starch hydrolysate |
| CN103467608A (en) * | 2013-09-27 | 2013-12-25 | 华仁药业股份有限公司 | Icodextrin and preparing method thereof |
| CN105131135A (en) * | 2015-09-17 | 2015-12-09 | 成都博佳制药有限公司 | Industrial production method of icodextrin |
| CN106397616A (en) * | 2016-08-30 | 2017-02-15 | 华南理工大学 | Preparation method of icodextrin for starch-based peritoneal dialysis solution |
| WO2018146345A1 (en) * | 2017-03-31 | 2018-08-16 | Opterion Health Ag | Carbohydrate composition for dialysis |
| CN110025631A (en) * | 2019-04-19 | 2019-07-19 | 西安乐析医疗科技有限公司 | A kind of novel peritoneal dialysis solution and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 陈香美 等: "《实用腹膜透析操作教程》", 31 May 2013, 人民军医出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110105460B (en) | Selenylation carboxymethyl pachyman and preparation method and application thereof | |
| US20200181292A1 (en) | Novel water-soluble natural polysaccharide antibacterial material and preparation method thereof | |
| CN101724091B (en) | Active carboxymethylpachymaran, production process and application thereof | |
| CN105131135B (en) | The industrialized preparing process of Icodextrin | |
| CN108752501B (en) | Organic acid salt-containing chitosan quaternary ammonium salt and preparation method and application thereof | |
| CN109456421A (en) | A kind of preparation of water soluble chitosan material and application method | |
| CN104877035A (en) | Preparation method of auricularia polysaccharide with hypoglycemic effect | |
| CN102702389A (en) | Thermo-sensitive chitosan derivative-hydroxypentyl chitosan and preparation method thereof | |
| CN108017724A (en) | A kind of preparation method of plant-derived chitosan | |
| CN105925648B (en) | A kind of tower draws albumen powder and polypeptide powder and its production method | |
| CN100467061C (en) | Scorpionfish-ink polysaccharide and its preparation | |
| CN107760740A (en) | A kind of big sugar of high-purity kanjak mannan and preparation method thereof, application | |
| CN101139404A (en) | Method for preparing chitosan lactate | |
| CN1245108C (en) | Novel method for producing inulin using heliangine or cicheriin as raw material | |
| CN110483649A (en) | A kind of preparation method of novel dextrin and its application in dialyzate | |
| CN114134190A (en) | Preparation method of zein active peptide-carried calcium ion nano chelate | |
| CN104892773A (en) | Preparation method of high-substitution-degree sodium carboxymethylcellulose | |
| CN102286044B (en) | Preparation method of natamycin laminar crystal | |
| CN103012536A (en) | Sodium fusidate crystallization method | |
| CN101993503B (en) | Method for preparing powdered sodium hyaluronate | |
| CN109136307B (en) | Method for preparing chitosan oligosaccharide by using helicase and application thereof | |
| CN107759711B (en) | Epoxy chitosan quaternary ammonium salt and preparation method thereof | |
| CN106432521A (en) | Preparation method of phosphate esterification bletilla striata polysaccharide | |
| CN1039419C (en) | Preparing process for super moisture absorbing resin | |
| CN109007710A (en) | A kind of production method extracted pectin from tamarind and synthesize edible water polo |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191122 |
|
| RJ01 | Rejection of invention patent application after publication |