CN110478088A - It is a kind of for large segmental bone defect treatment intramuscular at bone device - Google Patents
It is a kind of for large segmental bone defect treatment intramuscular at bone device Download PDFInfo
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- CN110478088A CN110478088A CN201910678126.7A CN201910678126A CN110478088A CN 110478088 A CN110478088 A CN 110478088A CN 201910678126 A CN201910678126 A CN 201910678126A CN 110478088 A CN110478088 A CN 110478088A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4601—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
- A61F2002/307—Prostheses for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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Abstract
A kind of intramuscular for large segmental bone defect treatment disclosed by the invention is at bone device, it includes guidance part and forming part, the forming part is arranged below guidance part, the aperture that the component that the two is formed passes through Minimally Invasive Surgery is placed in at bony site, skeletonization component fills expansion full of at bony site by the skeletonization component via guidance part to forming part, the forming part.A kind of intramuscular for large segmental bone defect treatment provided by the invention is at bone device, its is structurally reasonable, forming part has good elasticity, its aperture for being placed in Minimally Invasive Surgery together with guidance part when shrinking, skeletonization component is filled by guidance part to the inside of forming part, full of to which at bony site, realize the ectopic osteogenesis inside muscle struts operation.
Description
Technical field
The present invention relates to the field of medical instrument technology more particularly to a kind of intramuscular skeletonization for large segmental bone defect treatment
Device.
Background technique
It is current hair using bone tissue engineer technology treatment bone defect recently as the rapid development of bone tissue engineer
Exhibition trend, ectopic osteogenesis model can reduce the variable for influencing skeletonization in experiment relative to skeletonization in situ, can assess thin at backbone
Born of the same parents, osteogenic induction material effect.Ectopic ossification (HO) refers to the ectopic teratism in normal soft group betided other than bone tissue
Skeletonization is the process of an active development；Ectopic ossification is one kind of ectopic osteogenesis.
Patent CN107509699A discloses a kind of building of subcutaneous ectopic osteogenesis animal model of bone-grafting material, appraisal procedure
And application.The invention mixes self blood and bone-grafting material, after self blood clotting, by the mixture of self blood and bone-grafting material
It is implanted into subcutaneous rat, constructs the subcutaneous ectopic osteogenesis animal model of bone-grafting material；By a variety of bone formation performance characterizing methods to bone grafting
The subcutaneous ectopic osteogenesis animal model of material is assessed, and identifies the bone formation performance of bone-grafting material.The invention is by bone-grafting material and certainly
Subcutaneous ectopic osteogenesis model is implanted into after the mixing of body blood, on the one hand self blood can stablize bone-grafting material, prevent from shifting；On the other hand
Subcutaneous environment lacks the relevant cell factor of skeletonization and stem cell, generally requires additionally to add, and expensive, complicated for operation,
And self blood can bring cell factor and the stem cell of autologous into for subcutaneous bone-grafting material, so that subcutaneous ectopic osteogenesis model can
It is preferably applied to the bone formation performance of assessment bone-grafting material.
Patent CN101273057B discloses a kind of bone pattern generation protein 2 active peptide, it is characterised in that its structure are as follows:
C16H31O-NH-CCCCGGGS[PO4]-KIPKASSVPTELSAISTLYL.It overcomes existing BMP-2 half-life short, it is difficult to
Lasting to play a role and production equipment, preparation process are extremely complex, the production cycle is long, and low yield, price is also very expensive,
It is difficult to the deficiencies of being mass produced.Active site can sufficiently expose, its ectopic bone formation is stronger；It is easier to close on a large scale
At the advantages that expense is lower, and stability is more preferable, and the duration is long.
Patent disclosed in above-mentioned two pieces also rests on model foundation and simulated experiment stage, and there are no carry out relevant clinic
Treatment；In addition, being used in clinical treatment, since the hydrogel of intramuscular injection is softer, skeletonization exists and does not advise after individually injecting
Then the problem of.
Therefore, need to design a kind of intramuscular for large segmental bone defect treatment into bone device, solution is deposited in the prior art
The problem of.
Summary of the invention
The purpose of the present invention is in view of the above technical problems, a kind of flesh for large segmental bone defect treatment provided by the invention
Structurally reasonable at bone device in meat, forming part has good elasticity, and minimally invasive hand is placed in together with guidance part when shrinking
The aperture of art, skeletonization component are filled by guidance part to the inside of forming part, full of to realize inside muscle at bony site
Ectopic osteogenesis strut operation.
In order to solve the above technical problems, a kind of intramuscular skeletonization dress for large segmental bone defect treatment provided by the invention
It sets, including guidance part and forming part, the forming part is arranged below guidance part, and the component that the two is formed passes through Minimally Invasive Surgery
Aperture merging is to which at bony site, skeletonization component is filled swollen via guidance part to forming part, the forming part by the skeletonization component
It is swollen with full of at bony site.
In some embodiments, the forming part be can free wxpansion and contraction cystic structures.
In some embodiments, micropore is provided in the forming part, skeletonization component carries out substance by micropore and tissue
Exchange.
In some embodiments, the micropore is diamond shape, and sectional area is not more than 0.1mm2。
In some embodiments, the skeletonization group is divided into polymer, and the forming part and polymer are without rejection.
In some embodiments, the forming part is polyethylene, polycarbonate, polyethylene terephthalate, ether -one
Any one or several of polymer are composed.
In some embodiments, the expansion rate of the forming part is 60-90%.
In some embodiments, the skeletonization group is divided into polyethylene glycol, and making the expansion rate of forming part is 80%.
In some embodiments, the forming part is that polyethylene, polycarbonate and ether -one combination of polymers form.
In some embodiments, the polyethylene in the forming part, polycarbonate and ether -one polymer ratio are 10%:
50%:40%.
The invention has the advantages that:
Provided by the present invention for large segmental bone defect treatment intramuscular at bone device, structurally reasonable, forming part has
Good elasticity, is placed in together with guidance part the aperture of Minimally Invasive Surgery when shrinking, skeletonization component by guidance part fill to
The inside of forming part, full of to which at bony site, realize the ectopic osteogenesis inside muscle struts operation；In addition, in muscle
Interior creation fixed space, flexible formation portion can reduce the stimulation to muscle；Furthermore the present invention maintains good mass exchange energy
Power is conducive to ectopic osteogenesis.
Detailed description of the invention
It will be apparent and be easier reason by made detailed description, above-mentioned advantage of the invention in conjunction with the following drawings
Solution, these attached drawings are only schematical, are not intended to limit the present invention, in which:
Fig. 1 is structural schematic diagram of the intramuscular of the present invention for large segmental bone defect treatment at bone device；
Fig. 2 is schematic diagram of the intramuscular of the present invention for large segmental bone defect treatment at bone device clinical treatment；
Fig. 3 a and Fig. 3 b are skeletonization effect pictures in ectopic osteogenesis support body.
In figure:
10. guidance part；20. forming part；21. micropore；30. guide pin；40. muscle.
Specific embodiment
Combined with specific embodiments below and attached drawing, to a kind of herein described intramuscular for large segmental bone defect treatment at
Bone device is described in detail.
The embodiment recorded herein is specific specific embodiment of the invention, for illustrating design of the invention,
Be it is explanatory and illustrative, should not be construed as the limitation to embodiment of the present invention and the scope of the invention.Except what is recorded herein
Outside embodiment, those skilled in the art can also based on the claim of this application book and specification disclosure of that using aobvious and
The other technical solutions being clear to, these technical solutions include using any obvious to making for the embodiment recorded herein
The technical solution of substitutions and modifications.
The attached drawing of this specification is schematic diagram, aids in illustrating design of the invention, it is schematically indicated the shape of each section
And its correlation.It note that for the ease of clearly showing the structure of each component of the embodiment of the present invention, identical reference
Label is for indicating identical part.
A kind of intramuscular for large segmental bone defect treatment of the present invention at bone device structural schematic diagram, such as Fig. 1 and
Shown in Fig. 2 comprising guidance part 10 and forming part 20, the forming part 20 are arranged below guidance part 10, the group that the two is formed
The aperture that part passes through Minimally Invasive Surgery is placed in which at bony site, skeletonization component is via guidance part 10 to forming part 20, the forming part
20 fill expansion full of at bony site by the skeletonization component.
In the embodiment shown in fig. 1, the shape of the guidance part 10 is pyramidal structure, minimally invasive to strut skin realization
The inside of guidance part 10, guide pin is arranged in operation, the aperture of the small-sized one end merging Minimally Invasive Surgery of 10 diameter of guidance part, guide pin 30
30 pass through the bottom of guidance part 10 and enter in tissue, and the forming part 20 is arranged on guide pin 30 and is located under guidance part 10
Portion can receive telescopic action and be reliably fixed in the end of guide pin 30 since forming part 20 has good elasticity.
As an embodiment of the present invention, the forming part 20 be can free wxpansion and contraction cystic structures.Specifically
Ground, the forming part 20 have good elasticity, can be retractable to the cylindrical structure that diameter is 2-3mm, can also be according to skeletonization
The shape free wxpansion at position.In some embodiments, the Poisson's ratio of the forming part 20 is 0.1-0.15, preferred forming part
20 Poisson's ratio is 0.125.
In embodiment shown in FIG. 1, micropore 21 is provided in the forming part 20, skeletonization component passes through micropore 21 and tissue
Carry out mass exchange.As the one aspect of the present embodiment, the shape of the micropore 21 is diamond shape, and sectional area is not more than
0.1mm2, it is preferred that the sectional area of the micropore 21 is 0.08mm2.As the another aspect of the present embodiment, the micropore 21
Shape may be round, oval, triangle or other closed shapes, as long as its sectional area is not more than 0.1mm2.
The main function being arranged in this way is skeletonization component when being located at forming part 20, what skeletonization component will not be both arranged from forming part 20
It is flowed out in micropore 21, and can guarantee the function of mass exchange, i.e., tissue can be carried out corresponding by the micropore in forming part 20
Mass exchange, to meet various composition required for ectopic osteogenesis.
As an embodiment of the present invention, the skeletonization group is divided into polymer, and the forming part 20 and polymer are without row
Reprimand reaction, preferably to carry out ectopic osteogenesis in the inside of forming part 20.A in some embodiments, the forming part 20 is
Any one or several being composed of polyethylene, polycarbonate, polyethylene terephthalate, ether -one polymer.Specifically
Ground, forming part 20 can for polyethylene, polycarbonate, polyethylene terephthalate, ether -one polymer it is any,
It can be any two kinds of combination of polyethylene, polycarbonate, polyethylene terephthalate, ether -one polymer.
In the present invention, the expansion rate of the forming part 20 is 60-90%, and the expansion rate of the preferred forming part 20 is
70-80%, to meet the needs of ectopic osteogenesis according to according to the shape free wxpansion to ectopic osteogenesis.
As another embodiment of the invention, the skeletonization group is divided into polyethylene glycol, makes the expansion of forming part 20
Rate is 80%, skeletonization component can according to according to shape to ectopic osteogenesis, so that 20 free wxpansion of forming part, meet dystopy at
The needs of bone.
As yet another embodiment of the present invention, the forming part 20 is polyethylene, polycarbonate and ether -one polymer group
It closes.Specifically, polyethylene, polycarbonate and ether -one polymer ratio are 10%:50%:40% in the forming part 20.
Ectopic osteogenesis operation is carried out in the experimental animal Special surgical operation room by ultraviolet light irradiation, to anesthesia onset
Afterwards, preserved skin is carried out to art area using animal specific shaver.By new zealand white rabbit prostrate in surgical console, Medical iodine prevention is utilized
Wine carries out disinfection to range inner skin, conventional drape, and exposure experimental animal back is made minimally invasive aperture in back backbone side, led
The aperture for drawing the small one end merging Minimally Invasive Surgery of portion's diameter, makes forming part in musculature, passes through leading for guidance part end
Skeletonization component injection moulding portion 20 is then log out guide pin 30 and guide portion 10, layer-by-layer suture wound, and mark by needle 30.
Table 1 is blood examination comparison table, and Fig. 3 a and Fig. 3 b are skeletonization effect pictures in ectopic osteogenesis support body.
1 blood examination of table is surveyed as the result is shown
Table 1 the result shows that, the organization bracket be used for ectopic osteogenesis during, no cytotoxicity.
Tissue engineering bracket ectopic osteogenesis first is replanted into defect to the marrow after 2 weeks；Check experiment are as follows: directly by tissue
Engineering rack is implanted into bone defect position, and table 2 is experiment of machanics comparison table.
2 experiment of machanics comparison table of table
As shown in Table 2, by tissue engineering bracket ectopic osteogenesis first replanted after 2 weeks to the marrow defect more directly by tissue
Engineering rack is implanted into bone defect position, has better skeletonization effect at 20 weeks.
Skeletonization effect shows that skeletonization works well in ectopic osteogenesis support body, In in Fig. 3 a, Fig. 3 b ectopic osteogenesis support body
In rabbit critical size defects, tissue engineering bracket ectopic osteogenesis first is replanted into defect to the marrow after 2 weeks, as shown in Figure 3a；
Tissue engineering bracket is directly implanted into bone defect position, Fig. 3 b is shown；Tissue engineering bracket ectopic osteogenesis first is implanted into again after 2 weeks
Tissue engineering bracket is more directly implanted into bone defect position by bone defect position, has better skeletonization effect at 20 weeks.
A kind of intramuscular for large segmental bone defect treatment provided by the invention is at bone device, structurally reasonable, forming part
With good elasticity, the aperture of Minimally Invasive Surgery is placed in together with guidance part when shrinking, skeletonization component is filled out by guidance part
It is charged to the inside of forming part, with preferable full of having at bony site, realize the ectopic osteogenesis inside muscle struts operation
Promotional value.
The present invention is not limited to the above-described embodiments, anyone can obtain other various forms under the inspiration of the present invention
Product, it is all that there is technical side identical or similar to the present application however, make any variation in its shape or structure
Case is within the scope of the present invention.
Claims (10)
1. a kind of intramuscular for large segmental bone defect treatment is at bone device, including guidance part and forming part, the forming part is set
It sets below guidance part, the component that the two is formed passes through the aperture merging of Minimally Invasive Surgery at bony site, and skeletonization component is via leading
Draw portion to forming part, the forming part fills expansion full of at bony site by the skeletonization component.
2. it is according to claim 1 for large segmental bone defect treatment intramuscular at bone device, which is characterized in that it is described at
Type portion be can free wxpansion and contraction cystic structures.
3. it is according to claim 1 for large segmental bone defect treatment intramuscular at bone device, which is characterized in that it is described at
Micropore is provided in type portion, skeletonization component carries out mass exchange by micropore and tissue.
4. the intramuscular according to claim 3 for large segmental bone defect treatment is at bone device, which is characterized in that described micro-
Hole is diamond shape, and sectional area is not more than 0.1mm2。
5. it is according to claim 1 for large segmental bone defect treatment intramuscular at bone device, which is characterized in that it is described at
Bone group is divided into polymer, and the forming part and polymer are without rejection.
6. it is according to claim 1 for large segmental bone defect treatment intramuscular at bone device, which is characterized in that it is described at
Type portion is any one or several being composed of polyethylene, polycarbonate, polyethylene terephthalate, ether -one polymer.
7. it is according to claim 6 for large segmental bone defect treatment intramuscular at bone device, which is characterized in that it is described at
The expansion rate in type portion is 60-90%.
8. it is according to claim 1 for large segmental bone defect treatment intramuscular at bone device, which is characterized in that it is described at
Bone group is divided into polyethylene glycol, and making the expansion rate of forming part is 80%.
9. it is according to claim 6 for large segmental bone defect treatment intramuscular at bone device, which is characterized in that it is described at
Type portion is that polyethylene, polycarbonate and ether -one combination of polymers form.
10. the intramuscular according to claim 9 for large segmental bone defect treatment is at bone device, which is characterized in that described
Polyethylene, polycarbonate and ether -one polymer ratio in forming part are 10%:50%:40%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910678126.7A CN110478088A (en) | 2019-07-25 | 2019-07-25 | It is a kind of for large segmental bone defect treatment intramuscular at bone device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910678126.7A CN110478088A (en) | 2019-07-25 | 2019-07-25 | It is a kind of for large segmental bone defect treatment intramuscular at bone device |
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| CN110478088A true CN110478088A (en) | 2019-11-22 |
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| CN201910678126.7A Pending CN110478088A (en) | 2019-07-25 | 2019-07-25 | It is a kind of for large segmental bone defect treatment intramuscular at bone device |
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