CN110477849A - Self calibration optical coherence scanner and the method for sampling - Google Patents
Self calibration optical coherence scanner and the method for sampling Download PDFInfo
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- CN110477849A CN110477849A CN201910798897.XA CN201910798897A CN110477849A CN 110477849 A CN110477849 A CN 110477849A CN 201910798897 A CN201910798897 A CN 201910798897A CN 110477849 A CN110477849 A CN 110477849A
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- 238000005259 measurement Methods 0.000 claims description 13
- 238000001914 filtration Methods 0.000 claims description 7
- 238000012795 verification Methods 0.000 claims description 7
- 238000011835 investigation Methods 0.000 claims description 3
- 238000003384 imaging method Methods 0.000 abstract description 3
- 238000012014 optical coherence tomography Methods 0.000 description 13
- 210000001508 eye Anatomy 0.000 description 8
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
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Abstract
It the invention discloses self calibration optical coherence scanner and the method for sampling, including object lens, is configured and disposed to focus the light of destination path, also contains secondary sensor module, compare another time-resolved OCT image signal for determining sensor acquisition for obtaining；Light source module；Object lens, master reference, secondary sensor module, light source module are located at four light splitting branch roads of beam splitter.Light is generated by light source module, irradiates sample back reflection, master reference and secondary sensor module are entered after beam splitter.The present invention has the advantages of capable of voluntarily overcoming mobile sample, raising imaging accuracy.
Description
Technical field
The present invention relates to a kind of optical coherence scanning means more particularly to self calibration optical coherence scanner and sampling sides
Method.
Background technique
It is conventional in order to form three-dimensional (3D) laminogram of eye by optical coherence tomography (OCT): record
It is arranged in rows relative to each other in the volume of eye to be scanned (such as a-scan) and/or multiple OCT of layer (such as B-scan)
Image, and it is aligned these images relative to each other to form laminogram.However, after eyeball is mobile, resulting 3D
Laminogram shows the mobile artifact induced.These artifacts reduce the quality of 3D laminogram because, for example, eye or its
Geometry, profile or the altitude profile of single part (such as cornea) are reappeared in laminogram in a manner of low-qualityer.It is existing
Having technology such as Authorization Notice No. is the Chinese invention patent of CN105050483B, is disclosed a kind of for eye optical coherence tomography
The device of scanning and method for eye optical coherence tomography, which includes: camera chain, is configured to catch
Obtain the time-resolved camera review of eye；And OCT image acquiring unit, it is configured to obtain the time resolution of eye
OCT image.Make the measurement axis of OCT image acquiring unit and measurement axis being total to along device of camera chain using beam splitter
With measurement axis alignment.Device further includes control unit, is configured to determine the time point according to time-resolved camera review
The mobile data distinguished, the mobile data indicate movement of the eye relative to the measurement axis of device.Control unit is also configured to
At least part of OCT image is converted based on mobile data and laminogram is generated by OCT image.
Summary of the invention
It is an object of the invention to provide a kind of can voluntarily overcome that sample is mobile, improves imaging accuracy for the prior art
Self calibration optical coherence scanner and the method for sampling.
The technical scheme of the invention to solve the technical problem is: self calibration optical coherence scanner, including object
Mirror is configured and disposed to focus the light of destination path, also contains secondary sensor module, determines sensor for obtaining to compare
Another time-resolved OCT image signal obtained；
Light source module makes master reference and attached sensor module obtain different spies respectively for providing the light of different wave length
The picture signal of depth measurement degree；
Object lens, master reference, secondary sensor module, light source module are located at four light splitting branch roads of beam splitter.It is logical
It crosses light source module and generates light, irradiate sample back reflection, master reference and secondary sensor module are entered after beam splitter.Light source module
The light wave of different wave length is generated in different period, such as the sample signal for making master reference receive first period, the
Two period secondary sensor modules detect the storage picture signal of other period.And then obtaining two sensors
New signal and inspection have been obtained and have been worked alternatively between data.
To optimize above-mentioned technical proposal, the measure taken further include: light source module contains a main light source and a secondary light
Source；Projection between main light source and secondary light source through the realization of light source switch to beam splitter glazing.Main light source and secondary light source are adjustable
Humorous light source, the effect of light source switch be after the scanning that master reference or secondary sensor complete a cycle quickly by light source from
One wavelength is switched to another wavelength.By successively deeply, for wavelength lengthy, when the n-th period, XY adjusts mirror, Z axis pellicle mirror
It is in place, the sampled signal of wavelength when master reference obtains the n period under main light source, and store.When the (n+1)th period, conversion
The secondary light source of wavelength when to the n-1 period, picture signal and the master reference wave when main light source is in the n-1 period that secondary sensor obtains
Verification is compared in picture signal under long.Such as difference, then increase verification number, to filter off singular value, retain stationary value, and repeatedly
The wavelength of generation setting main light source and secondary light source.Filtering off can be from the averaging method in the existing method of sampling, interception with the logic retained
Method etc. is selected according to precision wish, is repeated no more.When obtaining scan image, due to sample position nonstatic, this is a
Particularity, the data that will cause a certain scan phase are nontarget areas.Therefore, the feelings measured by the self-checking of the present apparatus
Under condition, accurately scanning general image set can be obtained.Secondary sensor module contains secondary sensor and is located at its front end
Z axis pellicle mirror.By adjusting Z axis pellicle mirror so as to be produced from beam splitter to the optical signal that reference signal light and object lens come
Raw phase difference, to improve detection effect and efficiency.Mirror is adjusted in conjunction with XY, more can flexibly adjust the projected position of sample.
It is smaller in object lens, when such as endoscope similar structures or optical fiber solutions detection, XY adjusting mirror can be saved and transferred with computer program
Image is adjusted.The focus lamp for adjusting light source module transmitting light beam is equipped between light source module and beam splitter；It focuses
Mirror and the axis of object lens are be overlapped in optical path.It is above-mentioned to be designed as light source simple lens arrangement.Main light source and light source switch it
Between be equipped with prime focus mirror；Secondary focus lamp is equipped between secondary light source and light source switch；In prime focus mirror, secondary focus lamp and object lens
Axis is overlapped in optical path.It is above-mentioned to be designed as light source double lens arrangement.The Shell structure of the present apparatus belongs to the prior art, is
Length is not wasted, because without enumerating, those of ordinary skill in the art can pass through the reading self assemble to the prior art.
Self calibration optical coherence scanner, using such as claim 1 scanner, containing having the following steps,
1) primary data filling step: using wavelength D0 as light source, master reference obtains scanning signal, the number of execution cycle T0
According to filling；
2) scanning step: in period Tn, using wavelength Dn as light source, master reference obtains scanning signal Pn；
3) verify scanning step: in period Tn+1, using wavelength Dn-1 as light source, master reference obtains scanning contrast signal
Qn+1；
4) checking treatment step: scanning contrast signal Qn+1 is compared with scanning signal Pn-2, as identical or reach
Data filtering requires then by verification and storage result, if different in next cycle measurement repetition step 3), 4).Using
Which can mutually verify the picture signal of acquisition in the different scan periods on the two sensors, reject because of eye movement etc.
The measurement of mistake caused by factor.The principle that data filtering requires as sampling comparison, including be singly not limited to majority principle or it is average most
Remote principle, most value interception principle.
Due to comparing another time for determining sensor acquisition for obtaining present invention employs secondary sensor module is also contained
The OCT image signal of resolution；Light source module distinguishes master reference and attached sensor module for providing the light of different wave length
Obtain the picture signal of different investigation depths；Object lens, master reference, secondary sensor module, light source module are located at beam splitter
Four light splitting branch roads.Light is generated by light source module, irradiates sample back reflection, master reference and pair are entered after beam splitter
Sensor module.Light source module generates the light wave of different wave length in different period, such as when master reference being made to receive first
Between section sample signal, detect the storage picture signal of other period in second time period secondary sensor module.Into
And two sensors is made to have obtained and work alternatively between data in acquisition new signal and inspection.Thus have can voluntarily gram by the present invention
The advantages of taking mobile sample, raising imaging accuracy.
Detailed description of the invention
Fig. 1 is 1 light channel structure schematic diagram of the embodiment of the present invention；
Fig. 2 is 2 light channel structure schematic diagram of the embodiment of the present invention；
Fig. 3 is schematic diagram before 1 measurement result of the embodiment of the present invention is corrected；
Fig. 4 is schematic diagram after the amendment of 1 measurement result of the embodiment of the present invention.
Specific embodiment
Below in conjunction with attached embodiment, present invention is further described in detail.
Drawing reference numeral explanation: light source module 1, main light source 11, secondary light source 12, light source switch 13, focus lamp 2, prime focus
Mirror 21, secondary focus lamp 22, beam splitter 3, master reference 4, secondary sensor module 5, secondary sensor 51, Z axis pellicle mirror 52, XY are adjusted
Mirror 6, object lens 7, sample 8.
Embodiment 1: referring to Fig.1,3,4, self calibration optical coherence scanner and the method for sampling, including object lens 7, configure and
It is arranged as focusing the light of destination path, also contains secondary sensor module 5, determine the another of the acquisition of sensor 4 for obtaining to compare
One time-resolved OCT image signal；
Light source module 1 makes master reference 4 and attached sensor module 5 obtain difference respectively for providing the light of different wave length
The picture signal of investigation depth；
Object lens 7, master reference 4, secondary sensor module 5, light source module 1 are located at four light splitting branches of beam splitter 3
On.Light is generated by light source module 1, irradiates 8 back reflection of sample, master reference 4 and secondary sensor module are entered after beam splitter 3
5.Light source module 1 generates the light wave of different wave length in the different periods, such as the sample for making master reference 4 receive first period
This signal detects the storage picture signal of other period in second time period secondary sensor module 5.And then make two
Sensor has been obtained and has been worked alternatively between data in acquisition new signal and inspection.Light source module 1 contains a main light source 11 and one
A pair light source 12；Projection between main light source 11 and secondary light source 12 through the realization of light source switch 13 to 3 glazing of beam splitter.Main light source
11 and secondary light source 12 be tunable optical source, the effect of light source switch 13 is to complete one in master reference 4 or secondary sensor 51
Light source is quickly switched to another wavelength from a wavelength after the scanning in period.Successively to go deep into, for wavelength lengthy, n-th
When the period, XY adjusting mirror 6, Z axis pellicle mirror 52 are in place, and wavelength adopts when master reference 4 obtains the 11 lower n period of main light source
Sample signal, and store.When the (n+1)th period, the secondary light source 12 of wavelength when being transformed into the n-1 period, the image that secondary sensor 51 obtains
Verification is compared with picture signal of the master reference 4 when main light source 11 is in the n-1 period under wavelength in signal.Such as difference, then increase
Add verification number, to filter off singular value, retain stationary value, and the wavelength of iteration setting main light source 11 and secondary light source 12.Filter off with
The logic of reservation can be selected from averaging method, the interception method etc. in the existing method of sampling according to precision wish, no longer superfluous
It states.When obtaining scan image, due to 9 position nonstatic this particularity of sample, it will cause the data of a certain scan phase
It is nontarget area.Therefore, in the case where measuring by the self-checking of the present apparatus, it is whole that accurately scanning can be obtained
Image collection.Secondary sensor module 5 is containing secondary sensor 51 and positioned at the Z axis pellicle mirror 52 of its front end.It is semi-transparent by adjusting Z axis
Mirror 52 is so as to generate phase difference to the optical signal that reference signal light and object lens 7 come from beam splitter 3, to improve detection effect
And efficiency.Mirror 6 is adjusted in conjunction with XY, more can flexibly adjust the projected position of sample 9.It is smaller in object lens 7, such as endoscope class
When being detected like structure or optical fiber solutions, XY can be saved and adjust mirror 6 then image is adjusted with computer program.Light source die
The focus lamp 2 for emitting light beam for adjusting light source module 1 is equipped between block 1 and beam splitter 3；The axis of focus lamp 2 and object lens 7 exists
It is overlapped in optical path.It is above-mentioned to be designed as light source simple lens arrangement.The Shell structure of the present apparatus belongs to the prior art, in order not to wave
Take length, because without enumerating, those of ordinary skill in the art can pass through the reading self assemble to the prior art.Using such as
Claim 1 scanner, containing having the following steps,
1) primary data filling step: using wavelength D0 as light source, master reference 4 obtains scanning signal, execution cycle T0's
Data filling；
2) scanning step: in period Tn, using wavelength Dn as light source, master reference 4 obtains scanning signal Pn；
3) verify scanning step: in period Tn+1, using wavelength Dn-1 as light source, master reference 4 obtains scanning comparison letter
Number Qn+1；
4) checking treatment step: scanning contrast signal Qn+1 is compared with scanning signal Pn-2, as identical or reach
Data filtering requires then by verification and storage result, if different in next cycle measurement repetition step 3), 4).Using
Which can mutually verify the picture signal of acquisition in the different scan periods on the two sensors, reject because of eye movement etc.
The measurement of mistake caused by factor.The principle that data filtering requires as sampling comparison, including be singly not limited to majority principle or it is average most
Remote principle, most value interception principle.
The wavelength of the light emitted from light source module 1 is preferably in 1.1 to 1.7 microns of range, more preferably from about 1.2 microns.Light
The light that source module 1 emits divides through beam splitter 3 for destination path and reference path.The light of destination path adjusts mirror 6 through XY, is passing through
Object lens 7 project sample 8, then reflect from sample 8, return to beam splitter 3 through object lens 7.Z axis pellicle mirror 52 is in z-direction through driving
Motivation structure can move, and say that the light from beam splitter 3 is reflected back master reference 4, another part light is arrived through Z axis pellicle mirror 52
Up to secondary sensor 51.It is dephased for reaching the light of master reference 4, thus has more abundant information.Reach master reference 4
With the light of secondary sensor 51, according to different periods and light source module 1, different wavelength is coupled, and can obtain the figure of different depth
Picture, while the picture signal of acquisition can be mutually verified on the two sensors in the different scan periods, it rejects because of eye movement etc.
The measurement of mistake caused by factor.
Embodiment 2: referring to Fig. 2, only 1 structure of light source module is different from embodiment 1 for the present embodiment.
Prime focus mirror 21 is equipped between main light source 11 and light source switch 13；It is set between secondary light source 12 and light source switch 13
There is secondary focus lamp 22；The axis of prime focus mirror 21, secondary focus lamp 22 and object lens 7 is overlapped in optical path.It is above-mentioned to be designed as light source
Double lens arrangement.
Although preferred embodiment has been combined to describe the present invention, however, it is not to limit the invention, any this field
Technical staff can implement various change to the theme listed herein without departing from the spirit and scope of the present invention
Become, the displacement and modification of coordinate, therefore protection scope of the present invention is subject to the range limited depending on the claim proposed.
Claims (7)
1. self calibration optical coherence scanner, including object lens (7) are configured and disposed to focus the light of destination path；, special
Sign is: also containing secondary sensor module (5), determines the another time-resolved of sensor (4) acquisition described in comparison for obtaining
OCT image signal；
Light source module (1) makes the master reference (4) and attached sensor module (5) respectively for providing the light of different wave length
Obtain the picture signal of different investigation depths；
The object lens (7), master reference (4), secondary sensor module (5), light source module (1) are located at beam splitter (3)
Four light splitting branch roads.
2. self calibration optical coherence scanner according to claim 1, it is characterized in that: the light source module (1) contains
One main light source (11) and a secondary light source (12)；Through light source switch between the main light source (11) and secondary light source (12)
(13) projection to described beam splitter (3) glazing is realized.
3. self calibration optical coherence scanner according to claim 1, it is characterized in that: the secondary sensor module (5)
Containing secondary sensor (51) and positioned at the Z axis pellicle mirror (52) of its front end.
4. self calibration optical coherence scanner according to claim 2, it is characterized in that: the light source module (1) and institute
The focus lamp (2) for adjusting light source module (1) the transmitting light beam is equipped between the beam splitter (3) stated；The focusing
Mirror (2) and the axis of object lens (7) are be overlapped in optical path.
5. self calibration optical coherence scanner according to claim 2, it is characterized in that: the main light source (11) with it is described
Light source switch (13) between be equipped with prime focus mirror (21)；The secondary light source (12) and the light source switch (13) it
Between be equipped with secondary focus lamp (22)；The axis of the prime focus mirror (21), secondary focus lamp (22) and object lens (7) weighs in optical path
It is folded.
6. the self calibration optical coherence scanner method of sampling, it is characterized in that: being contained using scanner as described in claim 1
Following steps,
1) primary data filling step: using wavelength D0 as light source, master reference (4) obtains scanning signal, the number of execution cycle T0
According to filling；
2) scanning step: in period Tn, using wavelength Dn as light source, master reference (4) obtains scanning signal Pn；
3) verify scanning step: in period Tn+1, using wavelength Dn-1 as light source, master reference (4) obtains scanning contrast signal
Qn+1；
4) checking treatment step: scanning contrast signal Qn+1 is compared with scanning signal Pn-2, as identical or reach data
Filtering requirement then passes through verification and storage result, if different in next cycle measurement repetition step 3), 4).
7. the self calibration optical coherence scanner method of sampling according to claim 6, it is characterized in that: the data filtering
It is required that for the principle of sampling comparison, including singly it is not limited to majority principle or average farthest principle, most value interception principle.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007039267A2 (en) * | 2005-10-05 | 2007-04-12 | Carl Zeiss Meditec Ag | Optical coherence tomography for eye-length measurement |
| CN102753086A (en) * | 2010-01-29 | 2012-10-24 | 佳能株式会社 | Ophthalmologic imaging apparatus |
| CN104318541A (en) * | 2014-11-19 | 2015-01-28 | 深圳市斯尔顿科技有限公司 | Method for processing ophthalmology OCT images |
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2019
- 2019-08-28 CN CN201910798897.XA patent/CN110477849B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007039267A2 (en) * | 2005-10-05 | 2007-04-12 | Carl Zeiss Meditec Ag | Optical coherence tomography for eye-length measurement |
| CN102753086A (en) * | 2010-01-29 | 2012-10-24 | 佳能株式会社 | Ophthalmologic imaging apparatus |
| CN104318541A (en) * | 2014-11-19 | 2015-01-28 | 深圳市斯尔顿科技有限公司 | Method for processing ophthalmology OCT images |
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Effective date of registration: 20211208 Address after: 311106 Chongxian Street Siwei village, Yuhang District, Hangzhou City, Zhejiang Province Applicant after: Hangzhou Rongtan Nondestructive Inspection Equipment Co.,Ltd. Address before: 311400 No. 32, Golf Road, Dongzhou street, Fuyang District, Hangzhou City, Zhejiang Province Applicant before: Guan Qun |
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