CN110477032A - A kind of hydroxypropyl chitosan based on purple stem boneset extract/carboxymethyl chitosan carries powder and preparation method thereof - Google Patents
A kind of hydroxypropyl chitosan based on purple stem boneset extract/carboxymethyl chitosan carries powder and preparation method thereof Download PDFInfo
- Publication number
- CN110477032A CN110477032A CN201910633498.8A CN201910633498A CN110477032A CN 110477032 A CN110477032 A CN 110477032A CN 201910633498 A CN201910633498 A CN 201910633498A CN 110477032 A CN110477032 A CN 110477032A
- Authority
- CN
- China
- Prior art keywords
- chitosan
- preparation
- carboxymethyl chitosan
- hydroxypropyl
- aieas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
- A01N25/28—Microcapsules or nanocapsules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/12—Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Biotechnology (AREA)
- Pest Control & Pesticides (AREA)
- Toxicology (AREA)
- Botany (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of, and the hydroxypropyl chitosan based on purple stem boneset extract/carboxymethyl chitosan carries powder and preparation method thereof.Drug used in the present invention is the extract of Eupatorium adenophorum, is named as AIEAS, it is the compound polyelectrolyte formed with hydroxypropyl chitosan and carboxymethyl chitosan by electrostatic interaction that hydroxypropyl chitosan/carboxymethyl chitosan, which carries powder,.The compound polyelectrolyte, which is dispersed in water phase, is presented light blue opalescence, by granularmetric analysis and scanning electron microscopic observation, it is found that it is a kind of micron-sized polydispersion spherical particle.Hydroxypropyl chitosan of the invention/carboxymethyl chitosan, which carries powder, has slow release, biological degradability, not only clean and environmental protection, but also can come into full contact with crop.From the selection of carrier base material, chitosan and its derivative has the functions such as many characteristics, such as disinfection and deinsectization, pesticide synergistic, not only extends the application range of Eupatorium adenophorum, new direction is also opened for pesticide slow-release dosage form.
Description
Technical field
The invention belongs to carry powder subdomains, and in particular to and a kind of hydroxypropyl chitosan based on purple stem boneset extract/
Carboxymethyl chitosan carries powder and preparation method thereof.
Background technique
Along with the rapid development of chemical pesticide, there are the problem of gradually display.Since chemical pesticide toxicity is big,
It is not easily decomposed, can cause largely to remain in the soil after long-time service, and then threaten human health or even the entire ecosystem.Often
Year largely using after pesticide, the only pesticide of 0.1 % or so can act on target disease pest weeds, the pesticide of 99.9 % then into
Enter Agro-ecological System.Eupatorium adenophorum is a kind of invasive weeds, threatens the ecological environment balance in China for a long time.From purple
It can extract the substances such as alkaloid, terpenes, flavones, Phenylpropanoid Glycosides, steroidal in stem Herba Lycopi, there is desinsection, food refusal, inhibit growth hair
The effects of educating, is antibacterial substitutes traditional chemical pesticide with purple stem boneset extract, can play to Eupatorium adenophorum a degree of
It prevents and kill off, moreover it is possible to turn bane into boon, acquisition toxicity is smaller, remains less botanical pesticide.But since botanical pesticide belongs to plant
Secondary metabolite, performance is unstable, is easy to be degraded in the natural environment, so research and develop one kind can coating medicine to maintain
Pesticide stability, and the drug delivery technologies of pesticide sustained release can be made extremely urgent.
Pesticide water fundamental mode dosage form is a kind of novel sustained-release dosage type, not only clean and environmental protection, but also can be come into full contact with crop.From load
It is seen in the selection of body host material, chitosan and its derivative has the function such as many characteristics, such as disinfection and deinsectization, pesticide synergistic
Can, these features make chitosan and its derivative more attract attention in the preparation and application of pesticide slow-release system.
Studies have shown that introducing carboxymethyl in chitosan structure, water-soluble good polyampholyte carboxylic first is produced
Base enclosure glycan (Carboxymethyl Chitosan, CMC).And in the case where not changing chitosan alkalinity and electropositive situation, In
Hydroxypropyl is introduced on chitosan, and water-soluble positively charged hydroxypropyl chitosan (hydroxyl isopropyl can be prepared
chitosan HPCTS).It is positively charged in neutral aqueous phase solution according to the formation basic theory of compound polyelectrolyte
HPCTS can form Compound Water dispersed particle by electrostatic interaction with negatively charged CMC, prepare aqua type agriculture based on this
Medicine sustained release preparation.Research of the country in relation to aqua type pesticide slow-release dosage form is less at present.
Summary of the invention
The drawbacks of the purpose of the present invention is being directed to existing chemical pesticide and the unstable deficiency of botanical pesticide, provide one
Hydroxypropyl chitosan of the kind based on purple stem boneset extract/carboxymethyl chitosan carries powder and preparation method thereof.Of the invention
Raw material have the functions such as many characteristics, such as disinfection and deinsectization, pesticide synergistic, and biodegradable, not only extend purple stem pool
Blue application range, opens new direction also for pesticide slow-release dosage form.
AIEAS is coated in macromolecule carrier by the present invention by electrostatic interaction, is then successively adsorbed in outer layer positively charged
Hydroxypropyl chitosan and electronegative carboxymethyl chitosan, ultimately form micron-sized drug-loaded polyelectrolyte compound.
The purpose of the present invention is achieved through the following technical solutions.
A kind of hydroxypropyl chitosan based on purple stem boneset extract/carboxymethyl chitosan load powder, load powder
It is made of the raw material of following parts by weight:
1-10 parts of hydroxypropyl chitosan
1-10 parts of carboxymethyl chitosan
50 parts of water
1-5 parts of AIEAS；
The AIEAS is the extract of Eupatorium adenophorum.
A kind of above-described hydroxypropyl chitosan based on purple stem boneset extract/carboxymethyl chitosan carries powder
Preparation method, comprising the following steps:
(1) stirring is lower prepares hydroxypropyl sugar juice and carboxymethyl chitosan solution；
(2) under agitation, isometric carboxymethyl chitosan solution is added dropwise into hydroxypropyl sugar juice, is added dropwise
After the completion, continue to stir, obtain complex solution；
(3) AIEAS is added to the water ultrasonic dissolution, under the conditions of magnetic agitation, is added dropwise into hydroxypropyl sugar juice
Carboxymethyl chitosan solution is added dropwise after being blended uniformly in AIEAS solution, continues stirring after being added dropwise to complete to get based on purple stem
The hydroxypropyl chitosan of Herba Lycopi extract/carboxymethyl chitosan carries powder.
Preferably, step (1) stirring carries out under 90 DEG C of water-baths.
Preferably, the time of step (1) described stirring is 1-3h.
Preferably, the speed of step (2) described stirring is 500-1500rpm.
Preferably, in step (2), after being added dropwise to complete, continue to stir 10-30min.
Preferably, step (3) described AIEAS preparation the following steps are included:
Eupatorium adenophorum stem and leaf are dried, powder is beaten and are sieved, then hot reflux is carried out to dry powder with organic solvent, is revolved by decompression
It steams, water phase removal of impurities is filtered for multiple times to obtain clear liquid, last forced air drying to constant weight obtains the extract A IEAS of Eupatorium adenophorum.
It is further preferred that the organic solvent is one of ethyl alcohol, methanol and ethyl acetate or a variety of；The air blast
Dry is dry 48-96h under the conditions of 60-80 DEG C.
Preferably, the time of step (3) described blending is 3-7 min.
Preferably, in step (3), carboxymethyl chitosan solution continues to stir 10-30 min after being added dropwise to complete.
HPCTS/CMC/AIEAS of the invention is carried in powder, and HPCTS and CMC are respectively polycation and polyanion,
Water-soluble good and biodegradable, the two can form compound polyelectrolyte by electrostatic interaction in neutral aqueous solution, with
Aqua type medicament slow release dosage form is prepared based on this.Wherein chitosan and its derivative has disinfection and deinsectization, pesticide synergistic etc. all
More characteristics are widely used in controlled drug delivery systems, pharmaceutical carrier.It is multiple that purple stem boneset extract AIEAS is covered by polyelectrolyte
It closes in object structure, drug slow release, achievees the purpose that make to carry the sub- lasting medicine of powder.The combination of these components and each component
Above-mentioned blend range, pass through many experiments determine.
The present invention carries the medicament slow release performance of powder by the test of absorption delaying agents immersion method.
Compared with prior art, the present invention has the advantage that
1, the drug used in the present invention is the extract A IEAS of Eupatorium adenophorum, belongs to the secondary metabolite of plant, in natural ring
Not the problems such as not will cause residual difficult to degrade in border.
2, HPCTS/CMC/AIEAS of the invention, which carries powder, has slow release, biological degradability, is a kind of novel delay
Release dosage form, not only clean and environmental protection, but also can be come into full contact with crop.
3, the botanical pesticide AIEAS that HPCTS/CMC/AIEAS of the invention is carried in powder can be compound from polyelectrolyte
It is slowly released in object, drug release time is up to 168 hours.
Detailed description of the invention
Fig. 1 is the grain size distribution of HPCTS/CMC/AIEAS compound in embodiment 1.
Fig. 2 is the SEM picture of HPCTS/CMC/AIEAS compound in embodiment 2.
Fig. 3 is the cumulative release curve graph of AIEAS in the compound for using absorption delaying agents immersion method to measure in embodiment 3.
Specific embodiment
Specific implementation of the invention is further described below in conjunction with example and attached drawing, but embodiments of the present invention
It is without being limited thereto.
Embodiment 1
(1) Eupatorium adenophorum stem, leaf are dried, beats powder, 15g dry powder is weighed after forced air drying and is wrapped up with filter paper, 100ml is then added
Dehydrated alcohol extracts 12h.By extract vacuum rotary steam, water phase displacement removal of impurities repeatedly filters and obtains clear liquid, forced air drying to constant weight
Up to botanical pesticide AIEAS.
(2) carboxymethyl chitosan of 0.2 g and the hydroxypropyl chitosan of 0.6 g are weighed respectively, under 90 DEG C of water-baths respectively
Stirring is configured to the polyelectrolyte solution of 1 mg/ml and 3mg/ml.
(3) 50 mg AIEAS are taken, 10 ml deionized water ultrasonic dissolutions are added.Under the conditions of magnetic agitation, to 50 ml
AIEAS solution is added dropwise in the HPCTS solution of 3mg/ml, after 3 min are blended, dropwise by the CMC solution of 50 ml 1mg/ml
It is added in blended liquid, continues to stir 30 min after being added dropwise to complete.The complex solution made is sealed, is stored at room temperature.
(4) partial size of load powder is characterized using laser particle analyzer, Fig. 1 is HPCTS/CMC/AIEAS compound
Grain size distribution.The result shows that the system particle central diameter is 17.67 μm, and is distributed in polydispersion.It is immersed using absorption delaying agents
Method Experimental Characterization carries the cumulative release behavior of AIEAS in powder, and the entire test period is 7 days.Experiment show AIEAS with
The time increase cumulative release amount be gradually increased, cumulative release amount is reaching 57.6% after a week.
Embodiment 2
(1) Eupatorium adenophorum stem, leaf are dried, beats powder, 15g dry powder is weighed after forced air drying and is wrapped up with filter paper, 100ml is then added
Dehydrated alcohol extracts 12h.By extract vacuum rotary steam, water phase displacement removal of impurities repeatedly filters and obtains clear liquid, forced air drying to constant weight
Up to botanical pesticide AIEAS.
(2) carboxymethyl chitosan of 0.4 g and the hydroxypropyl chitosan of 1.2 g are weighed respectively, under 90 DEG C of water-baths respectively
Stirring is configured to the polyelectrolyte solution of 2 mg/ml and 6 mg/ml.
(3) 100 mg AIEAS are taken, 20 ml deionized water ultrasonic dissolutions are added.Under the conditions of magnetic agitation, to 100 ml
Be added dropwise AIEAS solution in the HPCTS solution of 6mg/ml, after 5 min are blended, by the CMC solution of 100 ml 2mg/ml by
It is added dropwise in blended liquid, continues to stir 25 min after being added dropwise to complete.The complex solution made is sealed, room temperature is protected
It deposits.
(4) using the microscopic appearance of scanning electron microscope observation HPCTS/CMC/AIEAS compound.Fig. 2 is HPCTS/
Square structure is presented under Electronic Speculum by freeze-drying sample preparation, load powder in the SEM picture of CMC/AIEAS compound, discovery,
The hexagonal crystal system being similar in crystallographic system.Illustrate after drug AIEAS is added, crystal seed can be provided in aqueous solution, then makees in electrostatic
With with the hexagonal crystal grain to form HPCTS/CMC/AIEAS of gradually growing up under mechanical shearing double action.It is immersed using absorption delaying agents
Method Experimental Characterization carries the cumulative release behavior of AIEAS in powder, and the entire test period is 14 days.Experiment show AIEAS with
The time increase cumulative release amount be gradually increased, cumulative release amount reaches 73.4% after two weeks.
Embodiment 3
(1) Eupatorium adenophorum stem, leaf are dried, beats powder, 15g dry powder is weighed after forced air drying and is wrapped up with filter paper, 100ml is then added
Dehydrated alcohol extracts 12h.By extract vacuum rotary steam, water phase displacement removal of impurities repeatedly filters and obtains clear liquid, forced air drying to constant weight
Up to botanical pesticide AIEAS.
(2) carboxymethyl chitosan of 0.2 g and the hydroxypropyl chitosan of 0.8 g are weighed respectively, under 90 DEG C of water-baths respectively
Stirring is configured to the polyelectrolyte solution of 1 mg/ml and 4 mg/ml.
(3) 50 mg AIEAS are taken, 10 ml deionized water ultrasonic dissolutions are added.Under the conditions of magnetic agitation, to 50 ml
Be added dropwise AIEAS solution in the HPCTS solution of 4mg/ml, after 5 min are blended, by the CMC solution of 50 ml 1mg/ml by
It is added dropwise in blended liquid, continues to stir 20 min after being added dropwise to complete.The complex solution made is sealed, room temperature is protected
It deposits.
(4) the cumulative release behavior of AIEAS in powder is carried using absorption delaying agents immersion method Experimental Characterization, Fig. 3 is
HPCTS/CMC/AIEAS compound is immersed in the water the cumulative release curve of rear AIEAS.Experiment shows that AIEAS increases with the time
Cumulative release amount is gradually increased, and the rate of release of AIEAS is very fast in first 12 hours, and in t=12 h, cumulative release amount reaches
To 41.5%.It is in 12-168 h immersing the time, the rate of release of AIEAS gradually becomes smaller, this is because in first 12 hours
A large amount of drug is released, medication amount in HPCTS/CMC/AIEAS is caused to reduce, so the sustained release rate of later period AIEAS slows down.
Claims (10)
1. a kind of hydroxypropyl chitosan based on purple stem boneset extract/carboxymethyl chitosan carries powder, which is characterized in that should
Powder is carried to be made of the raw material of following parts by weight:
1-10 parts of hydroxypropyl chitosan
1-10 parts of carboxymethyl chitosan
50 parts of water
1-5 parts of AIEAS；
The AIEAS is the extract of Eupatorium adenophorum.
2. preparing a kind of hydroxypropyl chitosan based on purple stem boneset extract described in claim 1/carboxymethyl chitosan to carry
The method of powder, which comprises the following steps:
(1) stirring is lower prepares hydroxypropyl sugar juice and carboxymethyl chitosan solution；
(2) under agitation, isometric carboxymethyl chitosan solution is added dropwise into hydroxypropyl sugar juice, is added dropwise
After the completion, continue to stir, obtain complex solution；
(3) AIEAS is added to the water ultrasonic dissolution, under the conditions of magnetic agitation, is added dropwise into hydroxypropyl sugar juice
Carboxymethyl chitosan solution is added dropwise after being blended uniformly in AIEAS solution, continues stirring after being added dropwise to complete to get based on purple stem
The hydroxypropyl chitosan of Herba Lycopi extract/carboxymethyl chitosan carries powder.
3. preparation method according to claim 2, which is characterized in that step (1) stirring carries out under 90 DEG C of water-baths.
4. preparation method according to claim 2, which is characterized in that the time of step (1) described stirring is 1-3h.
5. preparation method according to claim 2, which is characterized in that the speed of step (2) described stirring is 500-
1500rpm。
6. preparation method according to claim 2, which is characterized in that in step (2), carboxymethyl chitosan solution is dripped
Cheng Hou continues to stir 10-30min.
7. preparation method according to claim 2, which is characterized in that the preparation of step (3) described AIEAS includes following step
It is rapid:
Eupatorium adenophorum stem and leaf are dried, powder is beaten and are sieved, then hot reflux is carried out to dry powder with organic solvent, is revolved by decompression
It steams, water phase removal of impurities is filtered for multiple times to obtain clear liquid, last forced air drying to constant weight obtains the extract A IEAS of Eupatorium adenophorum.
8. preparation method according to claim 7, which is characterized in that the organic solvent is ethyl alcohol, methanol and acetic acid second
One of ester is a variety of；The forced air drying is dry 48-96h under the conditions of 60-80 DEG C.
9. preparation method according to claim 2, which is characterized in that the time of step (3) described blending is 3-7 min.
10. preparation method according to claim 2, which is characterized in that in step (3), carboxymethyl chitosan solution is added dropwise
Continue to stir 10-30 min after the completion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910633498.8A CN110477032A (en) | 2019-07-15 | 2019-07-15 | A kind of hydroxypropyl chitosan based on purple stem boneset extract/carboxymethyl chitosan carries powder and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910633498.8A CN110477032A (en) | 2019-07-15 | 2019-07-15 | A kind of hydroxypropyl chitosan based on purple stem boneset extract/carboxymethyl chitosan carries powder and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110477032A true CN110477032A (en) | 2019-11-22 |
Family
ID=68546108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910633498.8A Pending CN110477032A (en) | 2019-07-15 | 2019-07-15 | A kind of hydroxypropyl chitosan based on purple stem boneset extract/carboxymethyl chitosan carries powder and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110477032A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002304373A1 (en) * | 2002-02-12 | 2003-09-04 | Ranbaxy Laboratories Limited | Glucosamine-polyacrylate inter-polymer complex and applications thereof |
| CN1698901A (en) * | 2005-06-15 | 2005-11-23 | 蒋斯扬 | Chitosan or its derivative as drug carrier for carrying red sage root extract |
| CN101317588A (en) * | 2007-06-08 | 2008-12-10 | 中国农业科学院植物保护研究所 | Application of eupatorium adenophorum extracting solution as plant source pesticide |
| CN101856432A (en) * | 2010-05-19 | 2010-10-13 | 南京农业大学 | Preparation method of chitosan nanoparticles encapsulated tea polyphenol |
| CN105055372A (en) * | 2015-08-18 | 2015-11-18 | 华中农业大学 | Method for preparing carboxymethyl konjac glucomannan nano drug carrying microspheres |
| CN108948612A (en) * | 2018-06-19 | 2018-12-07 | 华南理工大学 | A kind of polyvinylalcohols starch sustained release film and preparation method thereof with plant pesticide controlled release properties |
-
2019
- 2019-07-15 CN CN201910633498.8A patent/CN110477032A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002304373A1 (en) * | 2002-02-12 | 2003-09-04 | Ranbaxy Laboratories Limited | Glucosamine-polyacrylate inter-polymer complex and applications thereof |
| CN1698901A (en) * | 2005-06-15 | 2005-11-23 | 蒋斯扬 | Chitosan or its derivative as drug carrier for carrying red sage root extract |
| CN101317588A (en) * | 2007-06-08 | 2008-12-10 | 中国农业科学院植物保护研究所 | Application of eupatorium adenophorum extracting solution as plant source pesticide |
| CN101856432A (en) * | 2010-05-19 | 2010-10-13 | 南京农业大学 | Preparation method of chitosan nanoparticles encapsulated tea polyphenol |
| CN105055372A (en) * | 2015-08-18 | 2015-11-18 | 华中农业大学 | Method for preparing carboxymethyl konjac glucomannan nano drug carrying microspheres |
| CN108948612A (en) * | 2018-06-19 | 2018-12-07 | 华南理工大学 | A kind of polyvinylalcohols starch sustained release film and preparation method thereof with plant pesticide controlled release properties |
Non-Patent Citations (1)
| Title |
|---|
| XUEQI ZENG ET AL.: "Halloysite nanotubes as nanocarriers for plant herbicide and its controlled release in biodegradable polymers composite film", 《APPLIED CLAY SCIENCE》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108496993B (en) | Using tea seed cake powder as the plant protection film agent of surfactant and preparation method and purposes | |
| JP5883388B2 (en) | Anthraquinone-containing derivatives as biochemical agricultural products | |
| CN101416631A (en) | Functional slow-release suspension seed-coating agents | |
| CN101869113B (en) | Cyclodextrin inclusion compound of rodents sterilant and preparation method thereof | |
| Muhaimin et al. | Microencapsulation of macaranga gigantea leaf extracts: Production and characterization | |
| CN109221276A (en) | A kind of Pogostemon cablin essential inclusion compound and its preparation method and application | |
| Anchi et al. | Dramatic improvement in pharmacokinetic and pharmacodynamic effects of sustain release curcumin microparticles demonstrated in experimental type 1 diabetes model | |
| Elsharabasy et al. | Phytoconstituents and hepatoprotective effect of Suaeda monoica Forssk and Suaeda pruinosa Lange | |
| WO2021109836A1 (en) | Tea saponin compound, preparation method therefor, and application thereof | |
| CN110477032A (en) | A kind of hydroxypropyl chitosan based on purple stem boneset extract/carboxymethyl chitosan carries powder and preparation method thereof | |
| Chapagain et al. | Phyto-saponins as a natural adjuvant for delivery of agromaterials through plant cuticle membranes | |
| Xie et al. | Electrostatic wrapping of eupatorium-based botanical herbicide with chitosan derivatives for controlled release | |
| CN101518258B (en) | Method for preparing matrine/carboxymethyl chitosan/phosphonic chitosan pesticide nanoparticle aqueous dispersion preparation | |
| CN113265031A (en) | Humic acid type insect-proof pheromone water-absorbent resin and preparation method thereof | |
| Dashora et al. | Development and characterization of pectin-prednisolone microspheres for colon targeted delivery | |
| Joshi et al. | Parthenium hysterophorus. L.(asteraceae): a boon or curse?(a review) | |
| Huang et al. | Emamectin-sodium alginate nano-formulation based on charge attraction with highly improved systemic translocation and photolysis resistance | |
| Mei et al. | Neurotoxicity study of lead-based perovskite nanoparticles | |
| CN103478139A (en) | Water surface floating granule for weeding | |
| CN104355379B (en) | A kind of algicide based on Alternanthera philoxeroides and its preparation method and application | |
| CN107296044B (en) | Plant-source pesticide surfactant and preparation method and application thereof | |
| CN113424840B (en) | Spodoptera frugiperda imago plant-derived repellent, and preparation method and application method thereof | |
| Kumar et al. | In-vitro hepatoprotective activity of Albizia lebbeck, Cassia occidentalis and Swertia chirata on HepG2 cells | |
| Kumar et al. | Establishment of rice husk by-product as pharmaceutical excipients | |
| CN107950606B (en) | Corn elephant repellent based on folium artemisiae argyi essential oil and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191122 |
|
| RJ01 | Rejection of invention patent application after publication |