CN110464350A - Microwave micro imaging method, apparatus and system - Google Patents

Microwave micro imaging method, apparatus and system Download PDF

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Publication number
CN110464350A
CN110464350A CN201910774539.5A CN201910774539A CN110464350A CN 110464350 A CN110464350 A CN 110464350A CN 201910774539 A CN201910774539 A CN 201910774539A CN 110464350 A CN110464350 A CN 110464350A
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microwave
photoacoustic signal
excitation point
absorption coefficient
sample
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CN110464350B (en
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徐飞
唐元梁
计钟
李桂香
谭仲威
吴新社
黄宁
黄德群
顾珩
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Guangdong Prov Medical Equipment & Instrument Research Inst
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/0507Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  using microwaves or terahertz waves
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/1702Systems in which incident light is modified in accordance with the properties of the material investigated with opto-acoustic detection, e.g. for gases or analysing solids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N22/00Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more

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Abstract

The present invention provides a kind of microwave micro imaging methods, apparatus and system, are related to biomedical imaging technical field.This method heats forward and backward the first photoacoustic signal and the second photoacoustic signal using pulse microwave by obtaining the target excitation point in the multiple excitation points for including to sample to be tested, then the microwave absorption coefficient of target excitation point is determined according to the first photoacoustic signal and the second photoacoustic signal, to obtain the microwave micro-image of sample to be tested according to the position coordinates of each excitation point and corresponding microwave absorption coefficient.Since the difference of both the second photoacoustic signal and the first photoacoustic signal includes the temperature variations of target excitation point caused by pulse microwave, so as to determine microwave absorption coefficient according to both the second photoacoustic signal and the first photoacoustic signal;Again since laser can focus, to reduce the area for exposing to the hot spot of excitation point, the excitation point that sample to be tested is measured is more, and then improves image resolution ratio, realizes microwave micro-imaging.

Description

Microwave micro imaging method, apparatus and system
Technical field
The present invention relates to biomedical imaging technical fields, in particular to a kind of microwave micro imaging method, device And system.
Background technique
Microwave imaging is the space point that dielectric property in organism is obtained using the electromagnetic wave of microwave spectrum as detection means Cloth, pathological tissues are diagnosed by the way that the difference of dielectric property between different tissues is presented, and method mainly couples matchmaker to implantation Sample to be tested in Jie carries out electromagnetic wave detection, in receiving end by rotable antenna battle array to realize the comprehensive collection to scattered wave With monitoring, finally show that the dielectric property of sample to be tested is distributed using the algorithm of iteration.
Microwave thermoacoustic imaging is a kind of new lossless medical imaging procedure developing in recent years, is irradiated and is given birth to using pulse microwave Object tissue excites the tomography technology of thermoacoustic signal (ultrasonic signal), due to the deep penetration of microwave, in biological tissue The thermoacoustic signal that portion generates carries the microwave absorption characteristic information of tissue, can be reconstructed in tissue by measuring thermoacoustic signal Microwave absorption distributed image.Therefore, thermal acoustic imaging is the imaging side of lossless one kind, high contrast, deep imaging depth, big visual field Method.
But since microwave is difficult to focus, microwave imaging resolution ratio depends on microwave wavelength (centimetres), and microwave thermal Resolution ratio is increased to acoustics resolution ratio (submillimeter magnitude) by acoustic imaging, so general microwave imaging resolution ratio is not high.
Summary of the invention
In view of this, the purpose of the present invention is to provide a kind of microwave micro imaging methods, apparatus and system.
To achieve the goals above, technical solution used in the embodiment of the present invention is as follows:
In a first aspect, the embodiment of the present invention provides a kind of microwave micro imaging method, it is applied to microwave micro imaging system Processor, which comprises
Obtain the first photoacoustic signal and the second photoacoustic signal, wherein first photoacoustic signal and second optoacoustic letter It number is respectively that target excitation point in the multiple excitation points for including heats forward and backward optoacoustic using pulse microwave and believes to sample to be tested Number;
The microwave absorption system of the target excitation point is determined according to first photoacoustic signal and second photoacoustic signal Number, wherein the microwave absorption coefficient is corresponding with the excitation point;
The sample to be tested is obtained according to the position coordinates of each excitation point and the corresponding microwave absorption coefficient Microwave micro-image.
Second aspect, the embodiment of the present invention provide a kind of microwave microscopic imaging device, are applied to microwave micro imaging system Processor, described device includes:
Photoacoustic signal obtains module, for obtaining the first photoacoustic signal and the second photoacoustic signal, wherein first optoacoustic Signal and second photoacoustic signal are respectively that the target excitation point in the multiple excitation points for including uses pulse to sample to be tested The forward and backward photoacoustic signal of microwave heating;
Microwave absorption coefficient determining module, for determining institute according to first photoacoustic signal and second photoacoustic signal State the microwave absorption coefficient of target excitation point, wherein the microwave absorption coefficient is corresponding with the excitation point;
Image generation module, for the position coordinates and the corresponding microwave absorption coefficient according to each excitation point Obtain the microwave micro-image of the sample to be tested.
The third aspect, the embodiment of the present invention provide a kind of microwave micro imaging system, the microwave micro imaging system packet Processor is included, the processor is used to execute the microwave micro imaging method as described in any one of aforementioned embodiments.
Microwave micro imaging method provided in an embodiment of the present invention, apparatus and system include to sample to be tested by obtaining Multiple excitation points in target excitation point forward and backward the first photoacoustic signal and the second photoacoustic signal are heated using pulse microwave, Then the microwave absorption coefficient of target excitation point is determined according to the first photoacoustic signal and the second photoacoustic signal, to swash according to each The position coordinates and corresponding microwave absorption coefficient for sending out point obtain the microwave micro-image of sample to be tested.Due to the second photoacoustic signal Difference with both the first photoacoustic signals includes the temperature variations of target excitation point caused by pulse microwave, so as to root Microwave absorption coefficient is determined according to both the second photoacoustic signal and the first photoacoustic signal;Again since laser can focus, to reduce The area for exposing to the hot spot of excitation point, the excitation point that sample to be tested is measured is more, and then improves image resolution Rate realizes the microwave micro-imaging of sub-micrometer scale.
To enable the above objects, features and advantages of the present invention to be clearer and more comprehensible, preferred embodiment is cited below particularly, and cooperate Appended attached drawing, is described in detail below.
Detailed description of the invention
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below will be to needed in the embodiment attached Figure is briefly described, it should be understood that the following drawings illustrates only certain embodiments of the present invention, therefore is not construed as pair The restriction of range for those of ordinary skill in the art without creative efforts, can also be according to this A little attached drawings obtain other relevant attached drawings.
Fig. 1 shows the structural block diagram of microwave micro imaging system provided by the invention.
Fig. 2 shows the flow charts of microwave micro imaging method provided by the invention.
Fig. 3 shows the further flow chart of microwave micro imaging method provided by the invention.
Fig. 4 shows the schematic diagram of microwave micro imaging method provided by the invention.
Fig. 5 shows the functional block diagram of microwave microscopic imaging device provided by the invention.
Icon: 100- microwave micro imaging system;110- processor;120- laser generating unit;130- microwave occurs single Member;140- supersonic sounding unit;150- coupling unit;160- data acquisition unit;200- microwave microscopic imaging device;210- light Acoustical signal obtains module;220- microwave absorption coefficient determining module;230- image generation module.
Specific embodiment
Below in conjunction with attached drawing in the embodiment of the present invention, technical solution in the embodiment of the present invention carries out clear, complete Ground description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Usually exist The component of the embodiment of the present invention described and illustrated in attached drawing can be arranged and be designed with a variety of different configurations herein.
Therefore, the detailed description of the embodiment of the present invention provided in the accompanying drawings is not intended to limit below claimed The scope of the present invention, but be merely representative of selected embodiment of the invention.Based on the embodiment of the present invention, those skilled in the art Member's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
It should be noted that the relational terms of term " first " and " second " or the like be used merely to an entity or Operation is distinguished with another entity or operation, and without necessarily requiring or implying between these entities or operation, there are any This actual relationship or sequence.Moreover, the terms "include", "comprise" or its any other variant be intended to it is non-exclusive Property include so that include a series of elements process, method, article or equipment not only include those elements, but also Further include other elements that are not explicitly listed, or further include for this process, method, article or equipment it is intrinsic Element.In the absence of more restrictions, the element limited by sentence "including a ...", it is not excluded that including described There is also other identical elements in the process, method, article or equipment of element.
The present invention provides a kind of microwave micro imaging systems 100, for obtaining high-resolution microwave micro-image.Please It refering to fig. 1, is the structural block diagram of microwave micro imaging system 100 provided by the invention.Microwave micro-imaging provided by the invention System 100 includes: processor 110, laser generating unit 120, microwave generating unit 130, supersonic sounding unit 140, coupling list Member 150, data acquisition unit 160 and focusing unit (not shown).Wherein, processor 110 and laser generating unit 120, micro- Wave generating unit 130 and data acquisition unit 160 are electrically connected, supersonic sounding unit 140, data acquisition unit 160 with And processor 110 is sequentially connected electrically.
Wherein, laser generating unit 120 be used under the control of processor 110, to be set in coupling unit 150 to The target excitation point emission pulse laser of sample.In a kind of optional embodiment, the arteries and veins of the transmitting of laser generating unit 120 The pulsewidth of impulse light is 10ns, pulse recurrence frequency 10Hz, wavelength 1206mm.
Focusing unit is set between laser generating unit 120 and coupling unit 150, for laser generating unit 120 The pulse laser of transmitting is focused, to reduce the area of hot spot.
Microwave generating unit 130 is used for the controller in processor 110, emits pulse to the target excitation point of sample to be tested Microwave.In a kind of optional embodiment, microwave generating unit 130 is BW-6000HPT High-Power Microwave generator, frequency Rate is that 6GHz, pulse power are continuously adjusted in 80KW-300KW.And the pulse width of pulse microwave is 0.5 μ s, repetition rate For 50~500Hz, preferably 500Hz.
Coupling unit 150 is for placing sample to be tested.Specifically, coupling unit 150 may include the appearance of light transmission, saturating microwave Couplant in device and container, sample to be tested are just placed in couplant.Couplant makes sample to be tested be in isoperibol, together When may make photoacoustic signal that can be efficiently transmitted to supersonic sounding unit 140 so that imaging be more clear.
Supersonic sounding unit 140 is used for received ultrasonic signal, and is transmitted to processor after being converted into electric signal 110.In a kind of optional embodiment, the type of supersonic sounding unit 140 is the linear array probe of more array elements, and dominant frequency is 10MHz, relative bandwidth are 70% or so.
The electric signal that data acquisition unit 160 is used to transmit supersonic sounding unit 140 carries out frequency-selecting, filtering, modulus turn It the operations such as changes and obtains photoacoustic signal, and photoacoustic signal is transmitted to processor 110.
Processor 110 is used to determine the microwave absorption coefficient of each excitation point, and carries out image weight using matlab program It builds to obtain microwave micro-image and perform image display.
The present invention also provides a kind of microwave micro imaging methods, the place applied to above-mentioned microwave micro imaging system 100 Device 110 is managed, for obtaining high-resolution microwave micro-image.Referring to Fig. 2, being microwave micro-imaging side provided by the invention The flow chart of method.The microwave micro imaging method includes:
S201 obtains the first photoacoustic signal and the second photoacoustic signal.
Wherein, the first photoacoustic signal and the second photoacoustic signal are respectively the mesh in the multiple excitation points for including to sample to be tested Mark excitation point heats forward and backward photoacoustic signal using pulse microwave.
Referring to Fig. 3, being the further flow chart of microwave micro imaging method.The S201 includes:
S2011 controls laser generating unit 120 to target excitation point emission pulse laser.
Firstly, processor 110 controls the pulse laser that laser generating unit 120 emits special parameter, and single via focusing Member is radiated target excitation point after focusing.
S2012 receives the first photoacoustic signal that supersonic sounding unit 140 acquires.
Supersonic sounding unit 140 acquires the first photoacoustic signal, and the first photoacoustic signal is transmitted to processor 110.Due to Microwave generating unit 130 does not work also, and collected first photoacoustic signal is to use pulse microwave to target excitation point at this time Photoacoustic signal before heating.
S2013, after the first preset time, control microwave generating unit 130 emits pulse microwave simultaneously to target excitation point Continue preset duration to heat target excitation point.
That is, after allowing sample to be tested to cool down the first preset time, then control microwave generating unit 130 and sent out to target excitation point The pulse microwave of special parameter is penetrated, so that target excitation point heats up.Due to pulsed laser irradiation sample to be tested will lead to it is to be measured Sample heating emits pulse microwave to target excitation point if obtaining the first photoacoustic signal and directly controlling microwave generating unit 130 And continue preset duration, the temperature variation of target excitation point can be led to and non-fully by pulse microwave due to the presence of heat accumulation It determines, thus by can accurately test knot to obtain to avoid heat accumulation for cooling first preset time of sample to be tested Fruit.
Normally, the first preset time is 60~100s.Preferably, the first preset time is 100s.
In addition, needing in order to make sample to be tested increase enough temperature under the irradiation of pulse microwave to target Excitation point persistently emits pulse microwave preset duration.In a kind of optional embodiment, preset duration is 10~60s, preferably Ground, preset duration 20s.
S2014 controls laser generating unit 120 to target excitation point emission pulse laser again, and receives supersonic sounding The second photoacoustic signal that unit 140 acquires.
It is to be appreciated that the second photoacoustic signal is to use the photoacoustic signal after pulse microwave heating to target excitation point.
In addition, S2014 is consistent with S2011, details are not described herein.But it should be recognized that S2014 and S2013 the two Time interval between step should be as small as possible, to avoid thermal diffusion, leads to last measurement result inaccuracy.
S202 determines the microwave absorption coefficient of target excitation point according to the first photoacoustic signal and the second photoacoustic signal.
Wherein, microwave absorption coefficient is corresponding with excitation point.That is, each excitation point has corresponding microwave absorption coefficient.
It is the specific flow chart of S202 please continue to refer to Fig. 3.The S202 includes:
S2021 determines the temperature variation of target excitation point according to the first photoacoustic signal and the second photoacoustic signal.
Specifically, the first photoacoustic signal, the second photoacoustic signal and temperature variation meet formula:
Wherein, PA0For the first photoacoustic signal, and PA0∝ α Γ=α (AT0+ B) (i.e. PA0With α (AT0+ B) proportional), PA1For the second photoacoustic signal, and PA1∝α[A(T0+ Δ T)+B] (i.e. PA1With α [A (T0+ Δ T)+B] proportional), α is pre- The laser absorption coefficient of setting, A are the first presetting coefficient, and B is the second presetting coefficient, T0For the interior obtained in advance Environment temperature, Δ T are temperature variation.
S2022 determines the microwave absorption coefficient of target excitation point based on temperature variation and presetting parameter set.
Wherein, presetting parameter set includes the lasting preset duration of microwave radiation, microwave repetition rate, microwave energy The specific heat capacity of amount, the density of sample to be tested and sample to be tested.To temperature variation, presetting parameter set and microwave Absorption coefficient meets formula:
Wherein, Δ T is temperature variation, and preset duration t lasting for microwave radiation, f is microwave repetition rate, and β is Microwave absorption coefficient, H are microwave energy, and ρ is the density of sample to be tested, CpFor the specific heat capacity of sample to be tested.
It should be noted that the lasting preset duration of microwave radiation is preset duration, and it is microwave repetition rate f, micro- Wave energy H is the parameter for the pulse microwave that microwave generating unit 130 emits, the density of sample to be tested and the ratio of sample to be tested Thermal capacitance is the parameter learnt in advance.
In summary known to two formulas:
To microwave absorption coefficient
S203, the microwave for obtaining sample to be tested according to the position coordinates of each excitation point and corresponding microwave absorption coefficient are aobvious Micro- image.
In a kind of optional embodiment, matlab program progress image reconstruction is run using processor 110 and is obtained Microwave micro-image.
That is, the microwave micrograph of sample to be tested can be obtained after the microwave absorption coefficient for obtaining each excitation point Picture.It should be noted that replacement target swashs by adjusting the method for sample to be tested and the relative position of laser generating unit 120 Hair point.
In a kind of optional embodiment, microwave micro imaging system further includes sample position adjustment unit, and sample Position adjustment unit is electrically connected with processor 110, and sample position adjustment unit is set in coupling unit, and sample to be tested is placed In on sample position adjustment unit.To which the microwave absorption coefficient of every one target excitation point of determination, processor 110 will pass through The relative position of sample position adjustment unit adjustment sample to be tested phase and laser generating unit 120 is controlled, is swashed to replace target Point is sent out, so that it is determined that the microwave absorption coefficient of new target excitation point.
Referring to Fig. 4, being the schematic diagram of microwave micro imaging method provided by the invention.In utilization pulse microwave to be measured It is portable in the difference of the second photoacoustic signal and the first photoacoustic signal to have temperature information after sample is heated;Again due to temperature rise Information is related to microwave absorption coefficient of the sample to be tested to pulse microwave, therefore situation about determining in the other parameters of pulse microwave Under, it just can obtain microwave absorption coefficient.Since laser can focus, and then reduce the area for exposing to the hot spot of excitation point, In In the case that sample to be tested area is constant, area shared by each excitation point is smaller, so that increasing can survey on sample to be tested The quantity of fixed excitation point, and then image resolution ratio is improved, realize microwave micro-imaging.
In order to execute the corresponding steps in above-described embodiment and each possible mode, be given below a kind of microwave it is micro- at As the implementation of device 200, optionally, which can use above-mentioned processor shown in FIG. 1 110 device architecture.Further, referring to Fig. 5, Fig. 5 is a kind of microwave microscopic imaging device provided in an embodiment of the present invention 200 functional block diagram.It should be noted that microwave microscopic imaging device 200 provided by the present embodiment, basic principle and The technical effect of generation is identical with above-described embodiment, and to briefly describe, the present embodiment part does not refer to place, can refer to above-mentioned Corresponding contents in embodiment.The microwave microscopic imaging device 200 includes: that obtain module 210, microwave absorption coefficient true for photoacoustic signal Cover half block 220 and image generation module 230.
Wherein, photoacoustic signal obtains module 210 for obtaining the first photoacoustic signal and the second photoacoustic signal.
Specifically, photoacoustic signal obtains module 210 for first controlling laser generating unit 120 to target excitation point transmitting arteries and veins Then impulse light receives the first photoacoustic signal that supersonic sounding unit 140 acquires and controls micro- then after the first preset time Wave generating unit 130 emits pulse microwave to target excitation point and continues preset duration, finally controls laser generating unit again 120 to target excitation point emission pulse laser, and receives the second photoacoustic signal of the acquisition of supersonic sounding unit 140.
It is to be appreciated that in a kind of optional embodiment, photoacoustic signal obtain module 210 can be used for executing S201, S2011, S2012, S2013 and S2014.
Microwave absorption coefficient determining module 220 is used to determine that target is excited according to the first photoacoustic signal and the second photoacoustic signal The microwave absorption coefficient of point.
Specifically, microwave absorption coefficient determining module 220 is used to be determined according to the first photoacoustic signal and the second photoacoustic signal The temperature variation of target excitation point, and determine that the microwave of target excitation point is inhaled based on temperature variation and presetting parameter set Receive coefficient.
It is to be appreciated that microwave absorption coefficient determining module 220 can be used for executing in a kind of optional embodiment S202, S2021 and S2022.
Image generation module 230 be used for according to the position coordinates and corresponding microwave absorption coefficient of each excitation point obtain to The microwave micro-image of sample.
It is to be appreciated that image generation module 230 can be used for executing S203 in a kind of optional embodiment.
In conclusion microwave micro imaging method provided in an embodiment of the present invention, apparatus and system, by obtaining to be measured The target excitation point in multiple excitation points that sample includes heats forward and backward the first photoacoustic signal and the second light using pulse microwave Then acoustical signal determines the microwave absorption coefficient of target excitation point, thus root according to the first photoacoustic signal and the second photoacoustic signal The microwave micro-image of sample to be tested is obtained according to the position coordinates and corresponding microwave absorption coefficient of each excitation point.Due to second The difference of both photoacoustic signal and the first photoacoustic signal includes the temperature variations of target excitation point caused by pulse microwave, from And microwave absorption coefficient can be determined according to both the second photoacoustic signal and the first photoacoustic signal;Again since laser can focus, To reduce the area for the hot spot for exposing to excitation point, the excitation point that sample to be tested is measured is more, and then improves Image resolution ratio realizes microwave micro-imaging.
In several embodiments provided herein, it should be understood that disclosed device and method can also pass through Other modes are realized.The apparatus embodiments described above are merely exemplary, for example, flow chart and block diagram in attached drawing Show the device of multiple embodiments according to the present invention, the architectural framework in the cards of method and computer program product, Function and operation.In this regard, each box in flowchart or block diagram can represent the one of a module, section or code Part, a part of the module, section or code, which includes that one or more is for implementing the specified logical function, to be held Row instruction.It should also be noted that function marked in the box can also be to be different from some implementations as replacement The sequence marked in attached drawing occurs.For example, two continuous boxes can actually be basically executed in parallel, they are sometimes It can execute in the opposite order, this depends on the function involved.It is also noted that every in block diagram and or flow chart The combination of box in a box and block diagram and or flow chart can use the dedicated base for executing defined function or movement It realizes, or can realize using a combination of dedicated hardware and computer instructions in the system of hardware.
In addition, each functional module in each embodiment of the present invention can integrate one independent portion of formation together Point, it is also possible to modules individualism, an independent part can also be integrated to form with two or more modules.
It, can be with if the function is realized and when sold or used as an independent product in the form of software function module It is stored in a computer readable storage medium.Based on this understanding, technical solution of the present invention is substantially in other words The part of the part that contributes to existing technology or the technical solution can be embodied in the form of software products, the meter Calculation machine software product is stored in a storage medium, including some instructions are used so that a computer equipment (can be a People's computer, server or network equipment etc.) it performs all or part of the steps of the method described in the various embodiments of the present invention. And storage medium above-mentioned includes: that USB flash disk, mobile hard disk, read-only memory (ROM, Read-Only Memory), arbitrary access are deposited The various media that can store program code such as reservoir (RAM, Random Access Memory), magnetic or disk.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of microwave micro imaging method, which is characterized in that applied to the processor of microwave micro imaging system, the method Include:
Obtain the first photoacoustic signal and the second photoacoustic signal, wherein first photoacoustic signal and second photoacoustic signal point The target excitation point in multiple excitation points that Wei do not include to sample to be tested heats forward and backward photoacoustic signal using pulse microwave;
The microwave absorption coefficient of the target excitation point is determined according to first photoacoustic signal and second photoacoustic signal, In, the microwave absorption coefficient is corresponding with the excitation point;
The micro- of the sample to be tested is obtained according to the position coordinates of each excitation point and the corresponding microwave absorption coefficient Wave micro-image.
2. microwave micro imaging method according to claim 1, which is characterized in that described according to first photoacoustic signal And second photoacoustic signal determines that the step of microwave absorption coefficient of the target excitation point includes:
The temperature variation of the target excitation point is determined according to first photoacoustic signal and second photoacoustic signal;
The microwave absorption coefficient of the target excitation point is determined based on the temperature variation and presetting parameter set.
3. microwave micro imaging method according to claim 2, which is characterized in that first photoacoustic signal, described Two photoacoustic signals and the temperature variation meet formula:
Wherein, PA0For first photoacoustic signal, and PA0∝ α Γ=α (AT0+ B), PA1For second photoacoustic signal, and PA1 ∝α[A(T0+ Δ T)+B], α is presetting laser absorption coefficient, and A is the first presetting coefficient, and B is presetting second Coefficient, T0For the indoor environment temperature obtained in advance, Δ T is the temperature variation.
4. microwave micro imaging method according to claim 2, which is characterized in that the presetting parameter set includes micro- The lasting preset duration of wave radiation, microwave repetition rate, microwave energy, the density of sample to be tested and sample to be tested specific heat Hold, the temperature variation, the presetting parameter set and the microwave absorption coefficient meet formula:
Wherein, Δ T is the temperature variation, and preset duration t lasting for microwave radiation, f is the microwave repetition rate, β is the microwave absorption coefficient, and H is the microwave energy, and ρ is the density of the sample to be tested, CpFor the sample to be tested Specific heat capacity.
5. microwave micro imaging method described in any one of -4 according to claim 1, which is characterized in that the microwave is micro- Imaging system further includes laser generating unit, microwave generating unit, supersonic sounding unit and coupling unit, the sample to be tested It is set in the coupling unit, the processor and the laser generating unit, the microwave generating unit and described super The step of acoustic detection unit is electrically connected, the first photoacoustic signal of the acquisition and the second photoacoustic signal include:
The laser generating unit is controlled to the target excitation point emission pulse laser;
Receive the first photoacoustic signal of the supersonic sounding unit acquisition;
After the first preset time, controls the microwave generating unit and emit pulse microwave to the target excitation point and continue pre- If duration is to heat the target excitation point;
Laser generating unit described in secondary control emits the pulse laser to the target excitation point again, and receives the ultrasound and visit Survey the second photoacoustic signal of unit acquisition.
6. a kind of microwave microscopic imaging device, which is characterized in that applied to the processor of microwave micro imaging system, described device Include:
Photoacoustic signal obtains module, for obtaining the first photoacoustic signal and the second photoacoustic signal, wherein first photoacoustic signal And second photoacoustic signal is respectively target excitation point in the multiple excitation points for including to sample to be tested using pulse microwave Heat forward and backward photoacoustic signal;
Microwave absorption coefficient determining module, for determining the mesh according to first photoacoustic signal and second photoacoustic signal Mark the microwave absorption coefficient of excitation point, wherein the microwave absorption coefficient is corresponding with the excitation point;
Image generation module, for being obtained according to the position coordinates and the corresponding microwave absorption coefficient of each excitation point The microwave micro-image of the sample to be tested.
7. microwave microscopic imaging device according to claim 6, which is characterized in that the microwave absorption coefficient determining module For determining the temperature variation of the target excitation point according to first photoacoustic signal and second photoacoustic signal;
Described in the microwave absorption coefficient determining module is also used to determine based on the temperature variation and presetting parameter set The microwave absorption coefficient of target excitation point.
8. microwave microscopic imaging device according to claim 7, which is characterized in that first photoacoustic signal, described Two photoacoustic signals and the temperature variation meet formula:
Wherein, PA0For first photoacoustic signal, and PA0∝ α Γ=α (AT0+ B), PA1For second photoacoustic signal, and PA1 ∝α[A(T0+ Δ T)+B], α is presetting laser absorption coefficient, and A is the first presetting coefficient, and B is presetting second Coefficient, T0For the indoor environment temperature obtained in advance, Δ T is the temperature variation.
9. microwave microscopic imaging device according to claim 7, which is characterized in that the presetting parameter set includes micro- The lasting preset duration of wave radiation, microwave repetition rate, microwave energy, the density of sample to be tested and sample to be tested specific heat Hold, the temperature variation, the presetting parameter set and the microwave absorption coefficient meet formula:
Wherein, Δ T is the temperature variation, and preset duration t lasting for the microwave radiation, f is microwave repetition Frequency, β are the microwave absorption coefficient, and H is the microwave energy, and ρ is the density of the sample to be tested, CpTo be described to test sample The specific heat capacity of product.
10. a kind of microwave micro imaging system, which is characterized in that the microwave micro imaging system includes processor, the place Reason device is used to execute the microwave micro imaging method as described in any one of claim 1-5.
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