CN110452337A - A kind of degradable medical high molecular material and preparation method thereof - Google Patents
A kind of degradable medical high molecular material and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of degradable medical high molecular materials, it is characterized in that, it is made of each raw material of following parts by weight: 30-40 parts of vinyl modified star polylactic acid, 3-6 parts of Diacetone Acrylamide, 3-6 parts of 1- vinyl imidazole, 10-15 parts of end-vinyl ultra-branching polyester, 25-35 parts, 1-2 parts of initiator of ethenyl blocking polycaprolactone glycol 2,5-furandicarboxylic acid condensation polymer.The invention also discloses the preparation methods of the degradable medical high molecular material.Degradable medical high molecular material disclosed by the invention has good tissue sticking nature and degradable metabolic capability, and its quality is stablized, and mechanical mechanics property is excellent, can effectively kill germ, prevents the growth of germ.
Description
Technical field
The present invention relates to medical material tech field more particularly to a kind of degradable medical high molecular material and its preparation sides
Method.
Background technique
As economic fast development and scientific and technological are constantly progressive, the medical and health care system in China also achieves very big
, powerful guarantee is provided to the raising of people's physical fitness, these achievements have driven medical macromolecular materials rapidly to develop.
Urgent need with the continuous expansion of medical macromolecular materials application range and people to medical level is improved, to medical high
More stringent requirements are proposed for the performance of molecular material, and degradable medical high molecular material is exactly one of demand for meeting people
And the medical macromolecular materials with high added value, it is widely used in the production of the medical devices such as syringe, transfusion bottle, perfusion tube
With the artificial repair materials of human tissue organ.
Medical instrument made of degradable high polymer material is voluntarily degraded after completing set treatment purpose, is not deposited for a long time
It stays, can avoid biological inflammatory reaction that permanent implanted instrument causes in body long-term existence and biomethanics is not adapted to etc. asks
Topic, and catabolite is metabolizable, has no toxic side effect, and is increasingly becoming current researcher and doctor defends the heat of staff's research
Point.Current common degradable high polymer material mainly includes the materials such as polylactic acid, polycaprolactone, hydroxymethyl cellulose, these
The generally existing matter of material is crisp uneven, and flexibility is poor, non-stretchable, intensity is too low, often occurs during clinical use
Accidents, the clinical applicabilities such as fracture are extremely restricted.
108795003 A of Chinese invention patent CN discloses a kind of preparation method of Biodegradable medical material.It is described
A kind of Biodegradable medical material composition are as follows: the polydactyl acid of 100-120 part of mass fraction meter, 60-80 parts
Poly- carbonic acid fiber, 4-8 parts of reinforcing agent, 1-2 parts of lubricant, 2-5 parts of toughener, 2-3 parts of dispersing agent, 1-2 parts of antioxygens
Agent；The medical material function admirable, intensity is high, it is corrosion-resistant, can itself is degradable, will not cause damages to environment, simultaneously
Preparation method is simple, is suitable for large-scale production and application, but this material addition auxiliary agent is more, compatible between each ingredient
Property and material comprehensive performance need to be further increased.
Therefore, developing one kind has good tissue sticking nature and degradable metabolic capability, and quality is stablized, mechanical mechanics
The excellent degradable medical high molecular material of energy has very important significance.
Summary of the invention
In order to overcome the defects of the prior art, the present invention provides a kind of degradable medical high molecular material and its preparation side
Method, the preparation method simple process is easy to operate, of less demanding to equipment and reaction condition, and raw material sources are abundant, and price is low
It is honest and clean, it is nontoxic, it is suitble to large-scale production, there is biggish value for clinical application；The degradable medical macromolecule being prepared
Material has good tissue sticking nature and degradable metabolic capability, and its quality is stablized, and mechanical mechanics property is excellent, Neng Gouyou
Effect kills germ, prevents the growth of germ.
To achieve the above object of the invention, the technical solution adopted by the present invention is that: a kind of degradable medical high molecular material,
It is characterized in that, is made of each raw material of following parts by weight: 30-40 parts of vinyl modified star polylactic acid, Diacetone Acrylamide
3-6 parts, 3-6 parts of 1- vinyl imidazole, 10-15 parts of end-vinyl ultra-branching polyester, ethenyl blocking polycaprolactone glycol 2,5-
25-35 parts of furandicarboxylic acid condensation polymer, 1-2 parts of initiator.
Further, the initiator is selected from azodiisobutyronitrile, azobisisoheptonitrile, lauroyl peroxide, peroxidating
At least one of diisopropylbenzene (DIPB).
Further, the preparation method of the ethenyl blocking polycaprolactone glycol 2,5-furandicarboxylic acid condensation polymer, packet
It includes as follows: polycaprolactone glycol, 2,5-furandicarboxylic acid being added in high boiling solvent and form solution, then will be dissolved in addition
Into polymerization reaction kettle, in 3-4 hours progress esterifications of 220-240 DEG C of back flow reaction, catalyst is then added in sealing, is dropped
Be depressed into 100-300Pa, polycondensation reaction 12-18 hours at 240-250 DEG C, after polymerization inhibitor and prenol is added thereto again,
Continue insulation reaction 1-2 hours, after be cooled to room temperature, separate out polymer in water, then with mass fraction be successively 3-5%'s
Sodium hydroxide solution, ether washing, finally pass through drying, obtain the contracting of ethenyl blocking polycaprolactone glycol 2,5-furandicarboxylic acid
Polymers.
Further, the polycaprolactone glycol, 2,5-furandicarboxylic acid, high boiling solvent, catalyst, polymerization inhibitor, different
The mass ratio of pentenol is 1:1:(6-10): (0.3-0.6): (0.05-0.1): 0.1.
Preferably, the high boiling solvent is selected from dimethyl sulfoxide, n,N-Dimethylformamide, N-Methyl pyrrolidone, N,
At least one of N- dimethyl acetamide.
Preferably, the catalyst is selected from one or more of antimony oxide, antimony acetate, antimony glycol.
Preferably, the polymerization inhibitor is selected from tetrachloroquinone, l, one or more of 4- naphthoquinones, p-hydroxyanisole.
Further, the preparation method of the degradable medical high molecular material includes the following steps: each raw material by weight
Amount part is mixed to form mixture, then adds mixture into and melts co-extrusion in double screw extruder, using cooling, is formed,
Obtain degradable medical high molecular material.
Preferably, the melting extrusion technological parameter are as follows: control screw speed 55-75r/min, extrusion temperature 210-230
℃。
The beneficial effects of adopting the technical scheme are that
(1) a kind of degradable medical high molecular material provided by the invention, preparation method simple process is easy to operate, right
Equipment and reaction condition are of less demanding, and raw material sources are abundant, cheap, nontoxic, are suitble to large-scale production, have larger
Value for clinical application.
(2) a kind of degradable medical high molecular material provided by the invention, overcoming conventional medical high molecular material can drop
Solution performance is bad, and biocompatibility is bad, and mechanical mechanics property needs the technical issues of being further increased, and has good tissue
Sticking nature and degradable metabolic capability, and its quality is stablized, mechanical mechanics property is excellent, can effectively kill germ, prevent disease
The growth of bacterium.
(3) a kind of degradable medical high molecular material provided by the invention has vinyl on each bulk composition, is squeezing
Out in forming process, under the action of initiator, each ingredient is copolymerized, and is formed organic whole, is constructed three-dimensional cross-linked net
Lattice structure is conducive to the normal growth of new histoorgan, secondly, these nets when being applied to the reparation of human body artificial organ organ
Lattice structure also provides reaction compartment for biodegrade, so that material has more excellent degradability.
(4) a kind of degradable medical high molecular material provided by the invention, bulk composition includes star polylactic acid, hyperbranched
Polyester and polycaprolactone glycol 2,5-furandicarboxylic acid condensation polymer, these ingredients are linked together in the form of chemical bond, are mentioned
High material property stability, so that the advantages of material has both standby these types of material, good biocompatibility is nontoxic, can give birth to
Object degradation property is good, also in relation with the excellent good processing performance of mechanical property and condensation polymer of addition polymers；So that material is more
It is soluble, there is lower crystallinity, molecular surface there are the performances such as higher functionality, lesser hydrodynamic volume, melting is viscous
Spend it is lower, it is easy to produce and process；The addition of this biomaterial of polycaprolactone glycol 2,5- furandicarboxylic acid is so that material is comprehensive
More preferably, furan structure introduces main chain to performance, so that biodegradability is stronger.
(5) a kind of degradable medical high molecular material provided by the invention introduces Diacetone Acrylamide, carbonyl structure
Introducing processing can improve outside the mechanical mechanics property of material, moreover it is possible to photosensitization is played, when carbonyl content is higher, and this discarded kind
Material has preferable light degradation ability, that is to say, that the material combines light degradation and biodegrade, so that material is degradable
Ability enhancing；1- vinyl imidazole is introduced, the introducing of glyoxaline structure can improve material antibiotic property, make it have antibacterial sterilizing energy
Power.
Specific embodiment
In order to make those skilled in the art more fully understand technical solution of the present invention, and make features described above of the invention,
Purpose and advantage are more clear understandable, and the present invention will be further explained with reference to the examples below.Embodiment is only used for
It is bright the present invention rather than limit the scope of the invention.
Involved vinyl modified star polylactic acid is previously prepared in the following embodiments of the present invention, preparation method ginseng
It examines: the synthesis of vinyl modified star polylactic acid and performance study, Xu Qiongnan, Wuhan Engineering Univ, 2017；Other raw materials are
It is commercially available.
Embodiment 1
A kind of degradable medical high molecular material, which is characterized in that be made of each raw material of following parts by weight: vinyl changes
Property 30 parts of star polylactic acid, 3 parts of Diacetone Acrylamide, 3 parts of 1- vinyl imidazole, 10 parts of end-vinyl ultra-branching polyester, second
25 parts, 1 part of azodiisobutyronitrile of condensation polymer of alkenyl terminated polycaprolactone glycol 2,5- furandicarboxylic acid.
The preparation method of the ethenyl blocking polycaprolactone glycol 2,5-furandicarboxylic acid condensation polymer, include the following: by
Polycaprolactone glycol, 2,5-furandicarboxylic acid, which are added in dimethyl sulfoxide, forms solution, then will be dissolved in and be added to polymerization reaction
In kettle, sealing in 220 DEG C of back flow reactions, 3 hours progress esterifications, is then added antimony oxide, is depressurized to 100Pa, In
Polycondensation reaction 12 hours at 240 DEG C, after tetrachloroquinone and prenol is added thereto again, continue insulation reaction 1 hour, it is rear cold
But to room temperature, separate out polymer in water, then successively with mass fraction be 3% sodium hydroxide solution, ether wash, finally
By drying, ethenyl blocking polycaprolactone glycol 2,5-furandicarboxylic acid condensation polymer is obtained；The polycaprolactone glycol, 2,5-
Furandicarboxylic acid, dimethyl sulfoxide, antimony oxide, tetrachloroquinone, prenol mass ratio be 1:1:6:0.3:0.05:0.1.
The preparation method of the degradable medical high molecular material includes the following steps: by weight to mix each raw material
Mixture is formed, then adds mixture into and melts co-extrusion in double screw extruder, using cooling, sizing, obtains to drop
Solve medical macromolecular materials；The melting extrusion technological parameter are as follows: control screw speed 55r/min, 210 DEG C of extrusion temperature.
Embodiment 2
A kind of degradable medical high molecular material, which is characterized in that be made of each raw material of following parts by weight: vinyl changes
Property 33 parts of star polylactic acid, 4 parts of Diacetone Acrylamide, 4 parts of 1- vinyl imidazole, 11 parts of end-vinyl ultra-branching polyester, second
27 parts, 1.2 parts of azobisisoheptonitrile of condensation polymer of alkenyl terminated polycaprolactone glycol 2,5- furandicarboxylic acid.
The preparation method of the ethenyl blocking polycaprolactone glycol 2,5-furandicarboxylic acid condensation polymer, include the following: by
Polycaprolactone glycol, 2,5-furandicarboxylic acid, which are added in n,N-Dimethylformamide, forms solution, then will be dissolved in and be added to
In polymerization reaction kettle, sealing in 225 DEG C of back flow reactions, 3.3 hours progress esterifications, is then added antimony acetate, is depressurized to
150Pa, polycondensation reaction 14 hours at 242 DEG C, after be added l, 4- naphthoquinones and prenol thereto again, continue insulation reaction
1.2 hours, after be cooled to room temperature, separate out polymer in water, then successively with mass fraction be 3.5% sodium hydroxide it is molten
Liquid, ether washing, finally pass through drying, obtain ethenyl blocking polycaprolactone glycol 2,5-furandicarboxylic acid condensation polymer；It is described
Polycaprolactone glycol, 2,5- furandicarboxylic acid, N,N-dimethylformamide, antimony acetate, l, the mass ratio of 4- naphthoquinones, prenol
For 1:1:7:0.4:0.06:0.1.
The preparation method of the degradable medical high molecular material includes the following steps: by weight to mix each raw material
Mixture is formed, then adds mixture into and melts co-extrusion in double screw extruder, using cooling, sizing, obtains to drop
Solve medical macromolecular materials；The melting extrusion technological parameter are as follows: control screw speed 60r/min, 215 DEG C of extrusion temperature.
Embodiment 3
A kind of degradable medical high molecular material, which is characterized in that be made of each raw material of following parts by weight: vinyl changes
Property 35 parts of star polylactic acid, 4.5 parts of Diacetone Acrylamide, 4.5 parts of 1- vinyl imidazole, end-vinyl ultra-branching polyester 13
Part, 30 parts, 1.5 parts of lauroyl peroxide of ethenyl blocking polycaprolactone glycol 2,5- furandicarboxylic acid condensation polymer.
The preparation method of the ethenyl blocking polycaprolactone glycol 2,5-furandicarboxylic acid condensation polymer, include the following: by
Polycaprolactone glycol, 2,5-furandicarboxylic acid, which are added in N-Methyl pyrrolidone, forms solution, then will be dissolved in be added to it is poly-
It closes in reaction kettle, sealing in 230 DEG C of back flow reactions, 3.5 hours progress esterifications, is then added antimony glycol, is depressurized to
200Pa, polycondensation reaction 16 hours at 245 DEG C, after p-hydroxyanisole and prenol is added thereto again, it is anti-to continue heat preservation
Answer 1.5 hours, after be cooled to room temperature, separate out polymer in water, then successively with mass fraction be 4% sodium hydroxide it is molten
Liquid, ether washing, finally pass through drying, obtain ethenyl blocking polycaprolactone glycol 2,5-furandicarboxylic acid condensation polymer；It is described
Polycaprolactone glycol, 2,5- furandicarboxylic acid, N-Methyl pyrrolidone, antimony glycol, p-hydroxyanisole, the matter of prenol
Amount is than being 1:1:8:0.5:0.07:0.1.
The preparation method of the degradable medical high molecular material includes the following steps: by weight to mix each raw material
Mixture is formed, then adds mixture into and melts co-extrusion in double screw extruder, using cooling, sizing, obtains to drop
Solve medical macromolecular materials；The melting extrusion technological parameter are as follows: control screw speed 65r/min, 220 DEG C of extrusion temperature.
Embodiment 4
A kind of degradable medical high molecular material, which is characterized in that be made of each raw material of following parts by weight: vinyl changes
38 parts of star polylactic acid of property, 5.5 parts of Diacetone Acrylamide, 5 parts of 1- vinyl imidazole, 14 parts of end-vinyl ultra-branching polyester,
33 parts, 1.9 parts of initiator of ethenyl blocking polycaprolactone glycol 2,5- furandicarboxylic acid condensation polymer；The initiator is azo two
Isobutyronitrile, azobisisoheptonitrile, lauroyl peroxide, cumyl peroxide 1:2:3:2 in mass ratio are mixed.
The preparation method of the ethenyl blocking polycaprolactone glycol 2,5-furandicarboxylic acid condensation polymer, include the following: by
Polycaprolactone glycol, 2,5-furandicarboxylic acid, which are added in n,N-dimethylacetamide, forms solution, then will be dissolved in and be added to
In polymerization reaction kettle, in 235 DEG C of back flow reactions, 3.8 hours progress esterifications, antimony oxide is then added in sealing, is depressured
To 250Pa, polycondensation reaction 17 hours at 248 DEG C, after tetrachloroquinone and prenol is added thereto again, continue insulation reaction
1.9 hours, after be cooled to room temperature, separate out polymer in water, then successively with mass fraction be 4.5% sodium hydroxide it is molten
Liquid, ether washing, finally pass through drying, obtain ethenyl blocking polycaprolactone glycol 2,5-furandicarboxylic acid condensation polymer；It is described
The matter of polycaprolactone glycol, 2,5- furandicarboxylic acid, DMAC N,N' dimethyl acetamide, antimony oxide, tetrachloroquinone, prenol
Amount is than being 1:1:9:0.5:0.09:0.1.
The preparation method of the degradable medical high molecular material includes the following steps: by weight to mix each raw material
Mixture is formed, then adds mixture into and melts co-extrusion in double screw extruder, using cooling, sizing, obtains to drop
Solve medical macromolecular materials；The melting extrusion technological parameter are as follows: control screw speed 73r/min, 225 DEG C of extrusion temperature.
Embodiment 5
A kind of degradable medical high molecular material, which is characterized in that be made of each raw material of following parts by weight: vinyl changes
Property 40 parts of star polylactic acid, 6 parts of Diacetone Acrylamide, 6 parts of 1- vinyl imidazole, 15 parts of end-vinyl ultra-branching polyester, second
35 parts, 2 parts of lauroyl peroxide of condensation polymer of alkenyl terminated polycaprolactone glycol 2,5- furandicarboxylic acid.
The preparation method of the ethenyl blocking polycaprolactone glycol 2,5-furandicarboxylic acid condensation polymer, include the following: by
Polycaprolactone glycol, 2,5-furandicarboxylic acid, which are added in high boiling solvent, forms solution, then will be dissolved in and be added to polymerization instead
It answers in kettle, seals, in 240 DEG C of back flow reactions, 4 hours progress esterifications, catalyst is then added, is depressurized to 300Pa, 250
Polycondensation reaction 18 hours at DEG C, after polymerization inhibitor and prenol is added thereto again, continue insulation reaction 2 hours, after be cooled to
Room temperature separates out polymer in water, then successively with mass fraction be 5% sodium hydroxide solution, ether wash, finally pass through
It is dry, obtain ethenyl blocking polycaprolactone glycol 2,5-furandicarboxylic acid condensation polymer；The polycaprolactone glycol, 2,5- furans
Dioctyl phthalate, high boiling solvent, catalyst, polymerization inhibitor, prenol mass ratio be 1:1:10:0.6:0.1:0.1；It is described high boiling
Point solvent is dimethyl sulfoxide, N,N-dimethylformamide, N-Methyl pyrrolidone, DMAC N,N' dimethyl acetamide 1:3 in mass ratio:
2:2 is mixed；The catalyst is that antimony oxide, antimony acetate, antimony glycol 1:3:5 in mass ratio are mixed；It is described
Polymerization inhibitor is tetrachloroquinone, l, and 4- naphthoquinones, p-hydroxyanisole 1:2:4 in mass ratio are mixed.
The preparation method of the degradable medical high molecular material includes the following steps: by weight to mix each raw material
Mixture is formed, then adds mixture into and melts co-extrusion in double screw extruder, using cooling, sizing, obtains to drop
Solve medical macromolecular materials；The melting extrusion technological parameter are as follows: control screw speed 75r/min, 230 DEG C of extrusion temperature.
Comparative example 1
A kind of degradable medical high molecular material, it is essentially identical with the formula and preparation method of embodiment 1, the difference is that not having
There is addition vinyl modified star polylactic acid.
Comparative example 2
A kind of degradable medical high molecular material, it is essentially identical with the formula and preparation method of embodiment 1, the difference is that not having
There is addition Diacetone Acrylamide.
Comparative example 3
A kind of degradable medical high molecular material, it is essentially identical with the formula and preparation method of embodiment 1, the difference is that not having
There is addition 1- vinyl imidazole.
Comparative example 4
A kind of degradable medical high molecular material, it is essentially identical with the formula and preparation method of embodiment 1, the difference is that not having
There is addition ethenyl blocking polycaprolactone glycol 2,5- furandicarboxylic acid condensation polymer.
Comparative example 5
A kind of degradable medical high molecular material, it is essentially identical with the formula and preparation method of embodiment 1, the difference is that not having
There is addition end-vinyl ultra-branching polyester.
Comparative example 6
A kind of commercially available degradable medical high molecular material, main component is polylactic acid.
The degradable medical high molecular material described in above-described embodiment 1-5 and comparative example 1-6 is respectively according to country or industry
Standard is tested for the property, and test result is shown in Table 1, and the strain that wherein antibiotic rate test is used to test is staphylococcus aureus.
Table 1
| Test item | Tensile strength | Cytositimulation reaction | Degradation rate (soil buries method, 30 days) | Antibiotic rate |
| Unit | MPa | — | % | % |
| Embodiment 1 | 62 | It is non-stimulated | 91 | 98.6 |
| Embodiment 2 | 65 | It is non-stimulated | 93 | 98.8 |
| Embodiment 3 | 67 | It is non-stimulated | 94 | 99.0 |
| Embodiment 4 | 68 | It is non-stimulated | 94 | 99.1 |
| Embodiment 5 | 70 | It is non-stimulated | 95 | 99.3 |
| Comparative example 1 | 54 | It is non-stimulated | 83 | 98.2 |
| Comparative example 2 | 55 | It is non-stimulated | 82 | 98.0 |
| Comparative example 3 | 52 | It is non-stimulated | 84 | 85.0 |
| Comparative example 4 | 53 | It is non-stimulated | 83 | 97.5 |
| Comparative example 5 | 53 | It is non-stimulated | 81 | 97.8 |
| Comparative example 6 | 48 | It is non-stimulated | 78 | 79.0 |
As seen from Table 1, degradable medical high molecular material disclosed by the embodiments of the present invention has compared with commercial product
More excellent mechanical mechanics property, biocompatibility and antibiotic property, and degradation capability is more preferable.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and what is described in the above embodiment and the description is only the present invention
Principle, various changes and improvements may be made to the invention without departing from the spirit and scope of the present invention, these variation and
Improvement is both fallen in the range of claimed invention.The present invention claims protection scope by appended claims and its
Equivalent defines.
Claims (9)
1. a kind of degradable medical high molecular material, which is characterized in that be made of each raw material of following parts by weight: vinyl modified
30-40 parts of star polylactic acid, 3-6 parts of Diacetone Acrylamide, 3-6 parts of 1- vinyl imidazole, end-vinyl ultra-branching polyester 10-
15 parts, 25-35 parts, 1-2 parts of initiator of ethenyl blocking polycaprolactone glycol 2,5- furandicarboxylic acid condensation polymer.
2. a kind of degradable medical high molecular material according to claim 1, which is characterized in that the initiator is selected from even
At least one of nitrogen bis-isobutyronitrile, azobisisoheptonitrile, lauroyl peroxide, cumyl peroxide.
3. a kind of degradable medical high molecular material according to claim 1, which is characterized in that the ethenyl blocking is poly-
The preparation method of caprolactone diol 2,5-furandicarboxylic acid condensation polymer includes the following: by polycaprolactone glycol, 2,5- furans diformazan
Acid, which is added in high boiling solvent, forms solution, then will be dissolved in and be added in polymerization reaction kettle, and sealing is returned in 220-240 DEG C
Stream 3-4 hours progress esterifications of reaction, are then added catalyst, are depressurized to 100-300Pa, polycondensation is anti-at 240-250 DEG C
Answer 12-18 hours, after polymerization inhibitor and prenol is added thereto again, continue insulation reaction 1-2 hours, after be cooled to room temperature,
Separate out polymer in water, then be successively 3-5% with mass fraction sodium hydroxide solution, ether wash, finally through overdrying
It is dry, obtain ethenyl blocking polycaprolactone glycol 2,5-furandicarboxylic acid condensation polymer.
4. a kind of degradable medical high molecular material according to claim 3, which is characterized in that the polycaprolactone two
Alcohol, 2,5- furandicarboxylic acid, high boiling solvent, catalyst, polymerization inhibitor, prenol mass ratio be 1:1:(6-10): (0.3-
0.6):(0.05-0.1):0.1。
5. a kind of degradable medical high molecular material according to claim 3, which is characterized in that the high boiling solvent choosing
From at least one of dimethyl sulfoxide, N,N-dimethylformamide, N-Methyl pyrrolidone, DMAC N,N' dimethyl acetamide.
6. a kind of degradable medical high molecular material according to claim 3, which is characterized in that the catalyst is selected from three
Aoxidize one or more of two antimony, antimony acetate, antimony glycol.
7. a kind of degradable medical high molecular material according to claim 3, which is characterized in that the polymerization inhibitor is selected from four
Chloranil, l, one or more of 4- naphthoquinones, p-hydroxyanisole.
8. a kind of degradable medical high molecular material according to claim 1-7, which is characterized in that described to drop
The preparation method for solving medical macromolecular materials, includes the following steps: each raw material being mixed to form mixture by weight, then will
Mixture, which is added in double screw extruder, melts co-extrusion, using cooling, sizing, obtains degradable medical high molecular material.
9. a kind of degradable medical high molecular material according to claim 8, which is characterized in that the melting extrusion technique
Parameter are as follows: control screw speed 55-75r/min, 210-230 DEG C of extrusion temperature.
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| CN111840637A (en) * | 2020-05-08 | 2020-10-30 | 陈艳 | Material for artificial liver and preparation method thereof |
| CN113755021A (en) * | 2021-09-11 | 2021-12-07 | 中国人民解放军总医院第三医学中心 | 3D printing bone material and preparation method thereof |
| CN114989585A (en) * | 2022-05-27 | 2022-09-02 | 江苏康宝医疗器械有限公司 | Degradable medical material suitable for infusion apparatus and preparation method thereof |
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Application publication date: 20191115 |