CN110450487A - A kind of degradable drug packing material and preparation method thereof - Google Patents

A kind of degradable drug packing material and preparation method thereof Download PDF

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Publication number
CN110450487A
CN110450487A CN201910739095.1A CN201910739095A CN110450487A CN 110450487 A CN110450487 A CN 110450487A CN 201910739095 A CN201910739095 A CN 201910739095A CN 110450487 A CN110450487 A CN 110450487A
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original paper
nano
paper layer
layer
weight
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CN110450487B (en
Inventor
郑永渠
郑达钿
杨晖
徐云海
蔡财德
吴健生
李加乐
惠万银
李钿
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Guangdong Meishida Medicine Packaging Materials Co Ltd
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Guangdong Meishida Medicine Packaging Materials Co Ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/24—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of indefinite length
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
    • B29C65/52—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B27/10—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of paper or cardboard
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/28—Layered products comprising a layer of synthetic resin comprising synthetic resins not wholly covered by any one of the sub-groups B32B27/30 - B32B27/42
    • B32B27/281—Layered products comprising a layer of synthetic resin comprising synthetic resins not wholly covered by any one of the sub-groups B32B27/30 - B32B27/42 comprising polyimides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J103/00—Adhesives based on starch, amylose or amylopectin or on their derivatives or degradation products
    • C09J103/02—Starch; Degradation products thereof, e.g. dextrin
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
    • C09J11/02—Non-macromolecular additives
    • C09J11/04—Non-macromolecular additives inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2009/00—Layered products
    • B29L2009/005—Layered products coated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2255/00—Coating on the layer surface
    • B32B2255/12—Coating on the layer surface on paper layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2255/00—Coating on the layer surface
    • B32B2255/20—Inorganic coating
    • B32B2255/205—Metallic coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2255/00—Coating on the layer surface
    • B32B2255/28—Multiple coating on one surface
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/714—Inert, i.e. inert to chemical degradation, corrosion
    • B32B2307/7145—Rot proof, resistant to bacteria, mildew, mould, fungi
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/716—Degradable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/724—Permeability to gases, adsorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2439/00—Containers; Receptacles
    • B32B2439/80—Medical packaging
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2473/00—Characterised by the use of macromolecular compounds obtained by reactions forming a linkage containing oxygen or oxygen and carbon in the main chain, not provided for in groups C08J2459/00 - C08J2471/00; Derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2479/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen, or carbon only, not provided for in groups C08J2461/00 - C08J2477/00
    • C08J2479/04—Polycondensates having nitrogen-containing heterocyclic rings in the main chain; Polyhydrazides; Polyamide acids or similar polyimide precursors
    • C08J2479/08—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Mechanical Engineering (AREA)
  • Materials Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Inorganic Chemistry (AREA)
  • Wrappers (AREA)

Abstract

The present invention discloses a kind of degradable drug packing material and preparation method thereof, the packaging material includes original paper layer, one layer of composite adhesive is coated in the one side of original paper layer, original paper layer is bonded with plastic packaging film by composite adhesive, there is one layer of fungistatic coating on the another side of original paper layer, plating has one layer of aluminium coated on fungistatic coating；The present invention is using original paper layer as skeleton structure, make packaging material that there is good intensity, but since the sealing effect of original paper layer is poor, and main component is cellulose, polysaccharide and resin etc. can become the substance of microbial nutrition element, therefore aluminium coated and plastic packaging film are respectively on the two sides of original paper layer, it is able to ascend the sealing effect of packaging material, fungistatic coating and composite adhesive with fungistatic effect can play good fungistatic effect, inhibit the growth and breeding of microorganism, plastic packaging film and dry antibacterial layer are able to ascend the lear energy of composite construction simultaneously, guarantee the intensity of composite construction.

Description

A kind of degradable drug packing material and preparation method thereof
Technical field
The invention belongs to field of packaging material, specifically, being related to a kind of degradable drug packing material and its preparation Method.
Background technique
Packaging is a kind of product protected to production product, therefore according to the needs of target product, packaging material is needed Have corresponding function, with the fast development of pharmaceuticals industry, requirement for medical packaging technology also fast lifting, with this To promote the security performance of medicine.
In the development process of medical packaging technology, the multiple materials such as glassware and plastics were used, wherein glass system Product are easily broken since its weight is big, are not easy the disadvantages of transporting, and are largely gradually backed out medical packaging field at present, and On the one hand PVC plastic can not degrade, and since the particularity of medical packaging can not be simply recycled, and PVC plastic Material can add auxiliary agent in process, and part of auxiliary agent can be discharged into drug during packing and saving, to drug It pollutes, wherein it is especially the most serious with liquid drug, while the gas permeability of plastic Key works Drug packing is stronger, therefore can lead The holding time of drug is caused to substantially reduce, and for medical packaging, microbe density control has very high requirement, in addition to guaranteeing Except convenient transportation, airtightness are strong, it is also necessary to guarantee medical packaging for microorganism have good inhibitory effect, therefore how There is provided that a kind of gas permeability oxygen permeability is poor, the degradation material of humble biological pollution is to need at present to be used for pharmaceutical packing One of solve the problems, such as, in order to solve this problem, the present invention provides following technical schemes.
Summary of the invention
The purpose of the present invention is to provide a kind of degradable drug packing materials and preparation method thereof.
The technical problem to be solved in the invention are as follows:
1, cold punching aluminum material and plastic material, this kind of materials in the prior art, are mostly used for the packaging of solid medicine bottle Expect that strength seal is preferable, and there is certain intensity, is suitable as packaging material and carries out using but cold in Key works Drug packing It rushes aluminum material recycling to be not easy, can not degrade, can be caused damages to environment again after discarded, and traditional plastic material equally has The problem of non-degradable；
2, as pharmaceutical packing material, need to guarantee the safety problem of drug, therefore, drug packing material needs to have Good fungistatic effect and sealing performance guarantee that the preservation of drug is not in the process the exceeded situation of content of microorganisms.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of degradable drug packing material, including original paper layer are coated with one layer of composite adhesive in the one side of original paper layer, Original paper layer is bonded with plastic packaging film by composite adhesive, and antibacterial coating is coated on the another side of original paper layer, and antibacterial coating is dry Fungistatic coating is formed after dry, plating has one layer of aluminium coated on fungistatic coating.
When in use, one side of the plating with aluminium coated directly contacts the degradable drug packing material with drug；
The original paper layer is with a thickness of 0.08-0.2mm；
The preparation method of the degradable drug packing material, specifically comprises the following steps:
Step 1: coating one layer of composite adhesive in the one side of original paper layer, after composite adhesive drying drying, will mould Sealing film is attached on composite adhesive, is compounded to form original paper layer-composite adhesive-plastic packaging film three-layered node by dry type Structure；
Step 2: coating one layer of antibacterial coating on the another side of original paper layer, fungistatic coating is formed after drying is dry；
Step 3: plating attached one layer of aluminium coated, the thickness of the aluminium coated by vacuum aluminum-plating machine on the surface of fungistatic coating Degree is 0.02-0.04 μm, and aluminium coated carries out cooling winding in an aseptic environment after being formed, to form degradable Key works Drug packing material Material.
The present invention passes through setting aluminium coated-fungistatic coating-original paper layer-composite adhesive-plastic packaging film composite construction, benefit It uses original paper layer as skeleton structure, makes packaging material that there is good intensity, but since the sealing effect of original paper layer is poor, and Main component is the substance that cellulose, polysaccharide and resin etc. can become microbial nutrition element, therefore on the two sides of original paper layer It is respectively with aluminium coated and plastic packaging film, is able to ascend the sealing effect of packaging material, while there is the antibacterial painting of fungistatic effect Layer can play good fungistatic effect with composite adhesive, inhibit the growth and breeding of microorganism, to promote the safety of drug Property and the holding time, while plastic packaging film and dry antibacterial layer are able to ascend the lear energy of composite construction, guarantee multiple Close the intensity of structure.
The composite adhesive is made of raw material from the following weight:
Polyvinyl alcohol 6-9 parts by weight, cornstarch 20-25 parts by weight, deionized water 45-50 parts by weight, caryophyllus oil 1-1.5 Parts by weight, nanometer calcium carbonate 5-7 parts by weight, coupling agent 0.5-1 parts by weight and nano-antibacterial liquid 3-5 parts by weight；
The composite adhesive the preparation method comprises the following steps:
S11, polyvinyl alcohol is added in deionized water after heating for dissolving, cornstarch is added thereto, in 60-65 DEG C of temperature Spend lower heating water bath 1-1.5h；
S12, caryophyllus oil, coupling agent, nano-antibacterial liquid and nanometer calcium carbonate are sequentially added into step S11 product, stir After mixing, composite adhesive is obtained after heating water bath 1.5-2h at a temperature of 65-70 DEG C.
The composite adhesive is also equipped with good fungistatic effect in addition to having stickiness, to inhibit on original paper layer The growth and breeding of microorganism, while composite adhesive does not introduce poisonous and harmful substances pollution drug, in this step, compound gluing Agent with polyvinyl alcohol and cornstarch for main adhesive material, using caryophyllus oil and nano-antibacterial liquid as antimicrobial component；
The plastic packaging film is prepared by the processing of following raw material:
Polylactic acid 35-45 parts by weight, ethylenecarbon monoxide copolymer 1 5-25 parts by weight, polyimides 10-15, nanometer are anti- Bacterium solution 3-5 parts by weight, glycerol 2-3 parts by weight and caryophyllus oil 2-3 parts by weight；
The plastic packaging film the preparation method comprises the following steps:
S21, above-mentioned raw materials are sequentially added in reactor tank, is extruded as after heating stirring melting by single screw extrusion machine Evenly dispersed mixed molten condition；
S22, the mixture of the molten condition of extrusion is processed by plastic packaging film by the tape casting.
Plastic packaging film is prepared as main material by using polylactic acid and ethylenecarbon monoxide copolymer in the step, So that film is had good degradation property, but since polylactic acid film forming has the characteristics that gas permeability is strong, oxygen permeability is high, is unfavorable for The application of drug packing material, therefore by being mixed into suitable polyimides, reduce gas permeability, the oxygen permeability of film, while institute Stating caryophyllus oil has good inhibitory effect to Escherichia coli, and nano-antibacterial liquid then has well the breeding of a variety of common bacterias Inhibitory effect providing detection methods to the detection knot of Escherichia coli according to pharmacopeia 2010 editions and in medical packaging industry Fruit, which should must not be, to be detected, and is thus promoted plastic packaging film to the inhibitory effect of Escherichia coli etc., can effectively be inhibited packaging material The pollution of the breeding of the Escherichia coli of itself and external Escherichia coli to drug；
The antibacterial coating the preparation method comprises the following steps:
S31, stirring and dissolving in carboxymethyl chitosan addition deionized water is obtained into carboxymethyl chitosan sugar aqueous solution, wherein carboxylic The mass concentration of methyl chitosan in deionized water is 4%-8%, prepares the aqueous gelatin solution that mass concentration is 8%-20%；
S32, aqueous gelatin solution and carboxymethyl chitosan sugar aqueous solution that previous step obtains uniformly are mixed according to volume ratio 1:1 After conjunction, glycerol and nano-antibacterial liquid are added thereto, quality of the glycerol in the mixed solution of gelatin and carboxymethyl chitosan is dense Degree is 0.5%-1%, and nano-antibacterial liquid additive amount is the 3%-11% of the mixed liquor volume of gelatin and carboxymethyl chitosan；
S33, high-speed stirred, mixing time 14- are carried out to the product in step S32 with the revolving speed of 1600-2500r/min 20min obtains antibacterial coating after stirring；
The deacetylation of the carboxymethyl chitosan is 90%-96%；
In the step, antibacterial coating is prepared using gelatin and carboxymethyl chitosan as primary raw material, utilizes carboxymethyl The anti-microbial property of chitosan and nano-antibacterial liquid makes antibacterial coating have good fungistatic effect, and gelatin, carboxymethyl chitosan Equal materials can not will cause environmental pollution by fully degraded.
The nano-antibacterial liquid the preparation method comprises the following steps:
S1, modified Nano silver antibacterial agent is obtained to nano silver antimicrobials progress surface modification by titanate coupling agent, made Nano silver antimicrobials have good anti-settling performance；
S2, it takes in sodium citrate addition glycerol and dissolves, isothiazolinone is added after dissolution thereto again and is obtained with through step S1 The modified Nano silver antibacterial agent arrived is dispersed with stirring and uniformly obtains nano-antibacterial liquid.
The nano silver antimicrobials are the ZnO/Ag nano silver antimicrobials or TiO that silver carrying amount is 5%-15%2/ Ag nanometers Silver antibacterial agent；
Concentration of the nano silver antimicrobials in nano-antibacterial liquid is 1-13g/L, and sodium citrate is in nano-antibacterial liquid Concentration be 4-13g/L, concentration of the isothiazolinone in nano-antibacterial liquid be 4-16g/L；
Nano silver antimicrobials and isothiazolinone all have good sterilization, fungistatic effect in the step, and sodium citrate Then there is thickening effect, promote the dispersion effect of nano silver antibacterial agent, meanwhile, sodium citrate also has good anti-corrosion effect.
Beneficial effects of the present invention:
The present invention passes through setting aluminium coated-fungistatic coating-original paper layer-composite adhesive-plastic packaging film composite construction, benefit It uses original paper layer as skeleton structure, makes packaging material that there is good intensity, but since the sealing effect of original paper layer is poor, and Main component is the substance that cellulose, polysaccharide and resin etc. can become microbial nutrition element, therefore on the two sides of original paper layer It is respectively with aluminium coated and plastic packaging film, is able to ascend the sealing effect of packaging material, while there is the antibacterial painting of fungistatic effect Layer can play good fungistatic effect with composite adhesive, inhibit the growth and breeding of microorganism, to promote the safety of drug Property and the holding time, while plastic packaging film and dry antibacterial layer are able to ascend the lear energy of composite construction, guarantee multiple Close the intensity of structure；
The composite adhesive is also equipped with good fungistatic effect in addition to having stickiness, to inhibit on original paper layer The growth and breeding of microorganism, while composite adhesive does not introduce poisonous and harmful substances pollution drug, in this step, compound gluing Agent with polyvinyl alcohol and cornstarch for main adhesive material, using caryophyllus oil and nano-antibacterial liquid as antimicrobial component；
The plastic packaging film carries out processing system as main material by using polylactic acid and ethylenecarbon monoxide copolymer It is standby, so that film is had good degradation property, but since polylactic acid film forming has the characteristics that gas permeability is strong, oxygen permeability is high, no Conducive to the application of drug packing material, therefore by being mixed into suitable polyimides, gas permeability, the oxygen permeability of film are reduced, together Shi Suoshu caryophyllus oil has good inhibitory effect to Escherichia coli, and nano-antibacterial liquid then has the breeding of a variety of common bacterias Good inhibitory effect, and in medical packaging industry, inspection of the detection method to Escherichia coli is being provided according to pharmacopeia 2010 editions Survey result, which should must not be, to be detected, and is thus promoted plastic packaging film to the inhibitory effect of Escherichia coli etc., can effectively be inhibited to pack The pollution of the breeding of the Escherichia coli of material itself and external Escherichia coli to drug.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common Technical staff's all other embodiment obtained without creative efforts belongs to the model that the present invention protects It encloses.
Embodiment 1
A kind of degradable drug packing material, including original paper layer are coated with one layer of composite adhesive in the one side of original paper layer, Original paper layer is bonded with plastic packaging film by composite adhesive, and antibacterial coating is coated on the another side of original paper layer, and antibacterial coating is dry Fungistatic coating is formed after dry, plating has one layer of aluminium coated on fungistatic coating.
When in use, one side of the plating with aluminium coated directly contacts the degradable drug packing material with drug；
The original paper layer is with a thickness of 0.1mm；
The preparation method of the degradable drug packing material, specifically comprises the following steps:
Step 1: coating one layer of composite adhesive in the one side of original paper layer, after composite adhesive drying drying, will mould Sealing film is attached on composite adhesive, is compounded to form original paper layer-composite adhesive-plastic packaging film three-layered node by dry type Structure；
Step 2: coating one layer of antibacterial coating on the another side of original paper layer, fungistatic coating is formed after drying is dry；
Step 3: plating attached one layer of aluminium coated, the thickness of the aluminium coated by vacuum aluminum-plating machine on the surface of fungistatic coating Degree is 0.03 μm, and aluminium coated carries out cooling winding in an aseptic environment after being formed, to form degradable drug packing material.
The composite adhesive is made of raw material from the following weight:
8 parts by weight of polyvinyl alcohol, 25 parts by weight of cornstarch, 50 parts by weight of deionized water, 1 parts by weight of caryophyllus oil, nanometer 4 parts by weight of 6 parts by weight of calcium carbonate, 0.7 parts by weight of coupling agent and nano-antibacterial liquid；
The composite adhesive the preparation method comprises the following steps:
S11, polyvinyl alcohol is added in deionized water after heating for dissolving, cornstarch is added thereto, in 65 DEG C of temperature Lower heating water bath 1.5h；
S12, caryophyllus oil, coupling agent, nano-antibacterial liquid and nanometer calcium carbonate are sequentially added into step S11 product, stir After mixing, composite adhesive is obtained after heating water bath 1.5h at a temperature of 70 DEG C.
The plastic packaging film is prepared by the processing of following raw material:
40 parts by weight of polylactic acid, 20 parts by weight of ethylenecarbon monoxide copolymer, polyimides 12,4 weight of nano-antibacterial liquid Part, 2 parts by weight of 2 parts by weight of glycerol and caryophyllus oil；
The plastic packaging film the preparation method comprises the following steps:
S21, above-mentioned raw materials are sequentially added in reactor tank, is extruded as after heating stirring melting by single screw extrusion machine Evenly dispersed mixed molten condition；
S22, the mixture of the molten condition of extrusion is processed by plastic packaging film by the tape casting.
The antibacterial coating the preparation method comprises the following steps:
S31, stirring and dissolving in carboxymethyl chitosan addition deionized water is obtained into carboxymethyl chitosan sugar aqueous solution, wherein carboxylic The mass concentration of methyl chitosan in deionized water is 5%, prepares the aqueous gelatin solution that mass concentration is 10%；
S32, aqueous gelatin solution and carboxymethyl chitosan sugar aqueous solution that previous step obtains uniformly are mixed according to volume ratio 1:1 After conjunction, glycerol and nano-antibacterial liquid are added thereto, quality of the glycerol in the mixed solution of gelatin and carboxymethyl chitosan is dense Degree is 0.8%, and nano-antibacterial liquid additive amount is the 4% of the mixed liquor volume of gelatin and carboxymethyl chitosan；
S33, high-speed stirred is carried out to the product in step S32 with the revolving speed of 2200r/min, mixing time 16min is stirred Antibacterial coating is obtained after mixing；
The deacetylation of the carboxymethyl chitosan is 96%；
The nano-antibacterial liquid the preparation method comprises the following steps:
S1, modified Nano silver antibacterial agent is obtained to nano silver antimicrobials progress surface modification by titanate coupling agent, made Nano silver antimicrobials have good anti-settling performance；
S2, it takes in sodium citrate addition glycerol and dissolves, isothiazolinone is added after dissolution thereto again and is obtained with through step S1 The modified Nano silver antibacterial agent arrived is dispersed with stirring and uniformly obtains nano-antibacterial liquid.
The nano silver antimicrobials are the TiO that silver carrying amount is 13%2/ Ag nano silver antimicrobials；
Concentration of the nano silver antimicrobials in nano-antibacterial liquid is 4g/L, and sodium citrate is dense in nano-antibacterial liquid Degree is 4g/L, and concentration of the isothiazolinone in nano-antibacterial liquid is 8g/L.
Embodiment 2
A kind of degradable drug packing material, including original paper layer are coated with one layer of composite adhesive in the one side of original paper layer, Original paper layer is bonded with plastic packaging film by composite adhesive, and antibacterial coating is coated on the another side of original paper layer, and antibacterial coating is dry Fungistatic coating is formed after dry, plating has one layer of aluminium coated on fungistatic coating.
When in use, one side of the plating with aluminium coated directly contacts the degradable drug packing material with drug；
The original paper layer is with a thickness of 0.1mm；
The preparation method of the degradable drug packing material, specifically comprises the following steps:
Step 1: coating one layer of composite adhesive in the one side of original paper layer, after composite adhesive drying drying, will mould Sealing film is attached on composite adhesive, is compounded to form original paper layer-composite adhesive-plastic packaging film three-layered node by dry type Structure；
Step 2: coating one layer of antibacterial coating on the another side of original paper layer, fungistatic coating is formed after drying is dry；
Step 3: plating attached one layer of aluminium coated, the thickness of the aluminium coated by vacuum aluminum-plating machine on the surface of fungistatic coating Degree is 0.02 μm, and aluminium coated carries out cooling winding in an aseptic environment after being formed, to form degradable drug packing material.
The composite adhesive is made of raw material from the following weight:
7 parts by weight of polyvinyl alcohol, 50 parts by weight of deionized water, 1.5 parts by weight of caryophyllus oil, are received 25 parts by weight of cornstarch 6 parts by weight of rice calcium carbonate, 5 parts by weight of 1 parts by weight of coupling agent and nano-antibacterial liquid；
The composite adhesive the preparation method comprises the following steps:
S11, polyvinyl alcohol is added in deionized water after heating for dissolving, cornstarch is added thereto, in 60 DEG C of temperature Lower heating water bath 1.5h；
S12, caryophyllus oil, coupling agent, nano-antibacterial liquid and nanometer calcium carbonate are sequentially added into step S11 product, stir After mixing, composite adhesive is obtained after heating water bath 2h at a temperature of 65 DEG C.
The plastic packaging film is prepared by the processing of following raw material:
45 parts by weight of polylactic acid, 5 parts by weight of ethylenecarbon monoxide copolymer 1, polyimides 15,4 weight of nano-antibacterial liquid Part, 2 parts by weight of 2 parts by weight of glycerol and caryophyllus oil；
The plastic packaging film the preparation method comprises the following steps:
S21, above-mentioned raw materials are sequentially added in reactor tank, is extruded as after heating stirring melting by single screw extrusion machine Evenly dispersed mixed molten condition；
S22, the mixture of the molten condition of extrusion is processed by plastic packaging film by the tape casting.
The antibacterial coating the preparation method comprises the following steps:
S31, stirring and dissolving in carboxymethyl chitosan addition deionized water is obtained into carboxymethyl chitosan sugar aqueous solution, wherein carboxylic The mass concentration of methyl chitosan in deionized water is 6%, prepares the aqueous gelatin solution that mass concentration is 12%；
S32, aqueous gelatin solution and carboxymethyl chitosan sugar aqueous solution that previous step obtains uniformly are mixed according to volume ratio 1:1 After conjunction, glycerol and nano-antibacterial liquid are added thereto, quality of the glycerol in the mixed solution of gelatin and carboxymethyl chitosan is dense Degree is 0.5%, and nano-antibacterial liquid additive amount is the 6% of the mixed liquor volume of gelatin and carboxymethyl chitosan；
S33, high-speed stirred is carried out to the product in step S32 with the revolving speed of 2200r/min, mixing time 14min is stirred Antibacterial coating is obtained after mixing；
The deacetylation of the carboxymethyl chitosan is 96%；
The nano-antibacterial liquid the preparation method comprises the following steps:
S1, modified Nano silver antibacterial agent is obtained to nano silver antimicrobials progress surface modification by titanate coupling agent, made Nano silver antimicrobials have good anti-settling performance；
S2, it takes in sodium citrate addition glycerol and dissolves, isothiazolinone is added after dissolution thereto again and is obtained with through step S1 The modified Nano silver antibacterial agent arrived is dispersed with stirring and uniformly obtains nano-antibacterial liquid.
The nano silver antimicrobials are the ZnO/Ag nano silver antimicrobials that silver carrying amount is 13%；
Concentration of the nano silver antimicrobials in nano-antibacterial liquid is 6g/L, and sodium citrate is dense in nano-antibacterial liquid Degree is 4g/L, and concentration of the isothiazolinone in nano-antibacterial liquid is 4g/L.
Experimental result and analysis:
Tensile strength, oxygen throughput and life to the degradable drug packing material being prepared according to embodiment processing Object degradation rate is detected, and wherein biological degradation rate is detected (CO after compost 90 days using ISO14885 standard2Burst size), Concrete outcome is shown in Table 1:
Table 1
Detection project Tensile strength (Mpa) Oxygen transit dose (cm3/m2.24h.0.1Mpa) Biological degradation rate (%)
Embodiment 1 > 55 < 0.02 82
Embodiment 2 > 55 < 0.02 79
By upper table result it is found that degradable medicine bottle packaging material of the present invention has good degradation property and stretches strong Degree, while oxygen permeability is poor, meets the needs of Key works Drug packing.
Above content is only to structure of the invention example and explanation, affiliated those skilled in the art couple Described specific embodiment does various modifications or additions or is substituted in a similar manner, without departing from invention Structure or beyond the scope defined by this claim, is within the scope of protection of the invention.

Claims (9)

1. a kind of degradable drug packing material, which is characterized in that including original paper layer, one layer is coated in the one side of original paper layer again Adhesive is closed, original paper layer is bonded with plastic packaging film by composite adhesive, antibacterial coating, suppression are coated on the another side of original paper layer Fungistatic coating is formed after bacterium coating is dry, plating has one layer of aluminium coated on fungistatic coating；
The original paper layer with a thickness of 0.08-0.2mm；
The degradable drug packing material is prepared by following steps processing:
Step 1: one layer of composite adhesive is coated in the one side of original paper layer, it is after composite adhesive drying drying, plastic packaging is thin Film is attached on composite adhesive, is compounded to form original paper layer-composite adhesive-plastic packaging film three-decker by dry type；
Step 2: coating one layer of antibacterial coating on the another side of original paper layer, fungistatic coating is formed after drying is dry；
Step 3: plate attached one layer of aluminium coated by vacuum aluminum-plating machine on the surface of fungistatic coating, the aluminium coated with a thickness of 0.02-0.04 μm, aluminium coated carries out cooling winding in an aseptic environment after being formed, to form degradable drug packing material.
2. a kind of degradable drug packing material according to claim 1, which is characterized in that the composite adhesive by with The raw material of lower parts by weight is made:
Polyvinyl alcohol 6-9 parts by weight, cornstarch 20-25 parts by weight, deionized water 45-50 parts by weight, caryophyllus oil 1-1.5 weight Part, nanometer calcium carbonate 5-7 parts by weight, coupling agent 0.5-1 parts by weight and nano-antibacterial liquid 3-5 parts by weight；
The composite adhesive the preparation method comprises the following steps:
S11, polyvinyl alcohol is added in deionized water after heating for dissolving, cornstarch is added thereto, at a temperature of 60-65 DEG C Heating water bath 1-1.5h；
S12, caryophyllus oil, coupling agent, nano-antibacterial liquid and nanometer calcium carbonate are sequentially added into step S11 product, be stirred After uniformly, composite adhesive is obtained after heating water bath 1.5-2h at a temperature of 65-70 DEG C.
3. a kind of degradable drug packing material according to claim 1, which is characterized in that the plastic packaging film is by following Raw material processing is prepared:
Polylactic acid 35-45 parts by weight, ethylenecarbon monoxide copolymer 1 5-25 parts by weight, polyimides 10-15, nano-antibacterial liquid 3-5 parts by weight, glycerol 2-3 parts by weight and caryophyllus oil 2-3 parts by weight；
The plastic packaging film the preparation method comprises the following steps:
S21, above-mentioned raw materials are sequentially added in reactor tank, is extruded as uniformly after heating stirring melting by single screw extrusion machine The molten condition of dispersion mixing；
S22, the mixture of the molten condition of extrusion is processed by plastic packaging film by the tape casting.
4. a kind of degradable drug packing material according to claim 1, which is characterized in that the preparation of the antibacterial coating Method are as follows:
S31, stirring and dissolving in carboxymethyl chitosan addition deionized water is obtained into carboxymethyl chitosan sugar aqueous solution, wherein carboxymethyl The mass concentration of chitosan in deionized water is 4%-8%, prepares the aqueous gelatin solution that mass concentration is 8%-20%；
S32, the aqueous gelatin solution that previous step obtains uniformly is mixed with carboxymethyl chitosan sugar aqueous solution according to volume ratio 1:1 Afterwards, glycerol and nano-antibacterial liquid, mass concentration of the glycerol in the mixed solution of gelatin and carboxymethyl chitosan are added thereto For 0.5%-1%, nano-antibacterial liquid additive amount is the 3%-11% of the mixed liquor volume of gelatin and carboxymethyl chitosan；
S33, high-speed stirred, mixing time 14- are carried out to the product in step S32 with the revolving speed of 1600-2500r/min 20min obtains antibacterial coating after stirring.
5. a kind of degradable drug packing material according to claim 4, which is characterized in that the carboxymethyl chitosan Deacetylation is 90%-96%.
6. according to a kind of any degradable drug packing material of claim 2-4, which is characterized in that the nano-antibacterial Liquid the preparation method comprises the following steps:
S1, modified Nano silver antibacterial agent is obtained to nano silver antimicrobials progress surface modification by titanate coupling agent；
S2, it takes sodium citrate to be added in glycerol to dissolve, isothiazolinone is added and obtains through step S1 thereto again after dissolution Modified Nano silver antibacterial agent is dispersed with stirring and uniformly obtains nano-antibacterial liquid.
7. a kind of degradable drug packing material according to claim 6, which is characterized in that the nano silver antimicrobials are The ZnO/Ag nano silver antimicrobials or silver carrying amount of silver carrying amount 5%-15% are the TiO of 5%-15%2/ Ag nano silver antimicrobials.
8. a kind of degradable drug packing material according to claim 6, which is characterized in that the nano silver antimicrobials exist Concentration in nano-antibacterial liquid is 1-13g/L, and concentration of the sodium citrate in nano-antibacterial liquid is 4-13g/L, isothiazolinone Concentration in nano-antibacterial liquid is 4-16g/L.
9. a kind of preparation method of degradable drug packing material, which comprises the steps of:
Step 1: one layer of composite adhesive is coated in the one side of original paper layer, it is after composite adhesive drying drying, plastic packaging is thin Film is attached on composite adhesive, is compounded to form original paper layer-composite adhesive-plastic packaging film three-decker by dry type；
Step 2: coating one layer of antibacterial coating on the another side of original paper layer, fungistatic coating is formed after drying is dry；
Step 3: plate attached one layer of aluminium coated by vacuum aluminum-plating machine on the surface of fungistatic coating, the aluminium coated with a thickness of 0.02-0.04 μm, aluminium coated carries out cooling winding in an aseptic environment after being formed, to form degradable drug packing material.
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